ELECTRONIC DEVICE FOR the ANNOTATION OF DOCUMENT

ELECTRONIC DEVICE FOR the ANNOTATION OF DOCUMENT

Le dispositif électronique (12) comporte des moyens d'injection dans un document d'une application (22) d'annotation pour étendre le document. L'application (22) d'annotation est propre à être exécutée depuis le document étendu seulement dans un contexte d'exécution d'un module (60) de gestion de rendu de document d'une application (56) de navigation sur des données source et traitées du module (60) de gestion de rendu de document et en utilisant les mêmes fonctions que le module (60) de gestion de rendu de document et en ce que le document traité par l'application (56) de navigation comprend des éléments graphiques, l'application (22) d'annotation étant adaptée pour ancrer une annotation (78) à un point d'un élément graphique du document indépendamment des coordonnées de l'élément graphique dans le document.

Photobioreactor

ERZEUGUNG EINES THERAPEUTISCHEN MIKROSCHAUMS

Compositions and Methods for Induced Brown Fat Differentiation

The invention provides methods and compositions for inducing brown fat cell differentiation through modulation of both Prdm1β and C/EBPβ activity and/or expression. Also provided are methods for preventing or treating obesity or an obesity related disorder in a subject through stimulation of both Prdm1β and C/EBPβ expression and/or activity. Further provided are methods for identifying compounds that are capable of modulating both Prdm1β and C/EBPβ expression and/or activity.

Retractable sheath devices, systems, and methods

The invention is directed to delivery medical devices that enable consistent “on-demand” delivery of therapeutic agents to a vessel. The medical device of the current invention comprises retractable sheath comprising neckable elements. The medical device of the current invention comprises an expandable member, a hydrophilic coating comprising at least one therapeutic agent about the expandable member or structural layer and a retractable outer sheath with a selectively permeable microstructure. The design and methods disclosed herein ensures that therapeutic agent delivery occurs essentially only during retraction of the outer sheath, minimizing coating and/or therapeutic agent loss to the bloodstream and providing controlled delivery to the treatment site.

Pharmaceutical Combinations for the Treatment of Cancer

The disclosure provides combination therapies for the treatment of colorectal cancer and familial adenomatous polyposis (TAP).

Integration of third party application as quick actions

A computer readable media, a method, and a system registering a third party application providing an available communication system between a local user and a remote user identity, storing information related to the available communication system in a first database, obtaining contact information for the remote user identity from the third party application, determining a communication type for the third party application, pairing the remote user identity with a contact, and updating a graphical representation of contact information.

METALOCENOS AND PROCEDURES FOR THEIR PREPARATION AND USE.

SE SUMINISTRA UN METODO PARA FORMAR UN COMPUESTO DE TIPO DEL CICLOPENTADIENO SOPORTADO QUE COMPRENDE LA PUESTA EN CONTACTO DE UN COMPUESTO DEL TIPO DE CICLOPENTADIENO QUE COMPRENDA UN HALOGENO ACTIVO CON UN SOPORTE INORGANICO QUE TENGA UN GRUPO DE HIDROXIL SUPERFICIAL. TAMBIEN SE SUMINISTRA UN METODO PARA PREPARAR UN METALOCENO SOPORTADO QUE COMPRENDE LA REACCION DEL COMPUESTO DEL TIPO DEL CICLOPENTADIENO SOPORTADO CON UN COMPUESTO DE UN METAL DE TRANSICION BAJO CONDICIONES ADECUADAS. TAMBIEN SE SUMINISTRA UN PROCESO PARA PRODUCIR LIGANTES DEL TIPO DEL CICLOPENTADIENO PUENTEADO QUE TENGAN UN PUENTE QUE TENGA UNA RAMA QUE SEA UN GRUPO DE VINIL TERMINAL. TAMBIEN SE SUMINISTRAN METALOCENOS DE ESTOS LIGANTES. AUN MAS SE SUMINISTRA UN PROCESO PARA PRODUCIR LIGANTES DEL CICLOPENTADIENO PUENTEADO QUE TENGA UN PUENTE QUE TENGA UNA RAMA QUE TENGA UN HALOGENO ACTIVO TERMINAL. TAMBIEN SE SUMINISTRAN LOS NUEVOS LIGANTES RESULTANTES Y NUEVOS METALOCENOS SOPORTADOS PRODUCIDOS MEDIANTE ESTE METODO. ADEMASSE SUMINISTRAN CATALIZADORES DE METALOCENO SOPORTADO EN LOS QUE AL MENOS DOS METALOCENOS DE EFECTIVIDAD DIFERENTE SE ENCUENTRAN UNIDOS ENTRE SI A UN SOPORTE INORGANICO QUE TENGA GRUPOS DE HIDROXIDO SUPERFICIAL. TAMBIEN SE SUMINISTRA UNA POLIMERIZACION DE OLEFINA QUE EMPLEA LOS METALOCENOS SOPORTADOS, PUENTEADOS DE LA INVENCION ASI COMO EL PRODUCTO DE POLIMERO RESULTANTE. A METHOD IS PROVIDED TO FORM A COMPOSITE TYPE OF THE SUPPORTED CYCLOPENTADIENE THAT INCLUDES THE SETTING IN CONTACT OF A CYCLOPENTADIEN TYPE COMPOSITE THAT INCLUDES AN ACTIVE HALOGEN WITH AN INorganic SUPPORT THAT HAS A SUPERX GROUP. A METHOD IS ALSO SUPPLIED TO PREPARE A SUPPORTED METALOCENE THAT UNDERSTANDS THE REACTION OF THE CYCLOPENTADIEN TYPE COMPOSITE SUPPORTED WITH A COMPOSITE OF A TRANSITION METAL UNDER ADEQUATE CONDITIONS. A PROCESS IS ALSO PROVIDED TO PRODUCE BINDERS OF THE TYPE OF BRIDGED CYCLOPENTADIEN THAT HAVE A BRIDGE THAT HAS A BRANCH THAT IS A TERMINAL VINYL GROUP. METALOCENOS OF THESE BINDERS ...

Processo para preparação de um ligante ligado a polímero ligante ligado a polímero metaloceno ligado a polímero sistema catalisador de polimerização e processo de polimerização

Ligand or metallocene bound to polymer, process for preparing such ligand, polymeric catalytic system and polymerization process

Polymeeriliittyneet ligandit, polymeeriliittyneet metalloseenit, katalysaattorijärjestelmät, valmistus ja käyttö

Polymer bound ligands, process for production thereof, polymer bound metallocenes, catalyst systems and polymerization process

Manufacturing process of ligand bound to polymer, ligand or metallocene bound to polymer, polymerization catalytic system and a polymerization method

Prepn. of a polymer bound ligand useful as a metallocene catalyst component is claimed. The process comprises reacting a metallated polystyrene and an organo-halide cpd.. The polystyrene is metallated with an alkali metal. The organo-halide cpd. is of formula: XM(R)m X = a halide; M = Si, C, Ge, Sn, P or N; and each R = a hydrocarbyl gp. selected from (cyclo)alkyl, aryl and cyclopentadienyl-type gps. contg. 1-36 C atoms, with the proviso that: at least one R gp. = cyclopentadienyl-type gp., where the cyclopentadienyl-type gps. are cyclopentadienyl opt. substd., substd. indenyl, fluorenyl opt. substd., where the substits. include 1-12C hydrocarbyl gps., 1-12C alkoxy gps., or halide, and m is 2 or 3. Also claimed is the polymer bound ligand formed as above.

Polymer-linked ligands, polymer-linked metallocenes, catalyst systems, preparation and use

Polymer bound ligands, polymer bound metallocenes, catalyst systems, preparation, and use

Method of manufacture of polyolefine with broad distribution of molecular mass by using of catalytic system

A catalyst system comprising a bridged fluorenyl-containing metallocene, an unbridged metallocene, and a suitable cocatalyst and the use of such catalyst systems to produce olefin polymers. Also novel olefin polymers produced by those processes.

Catalyst systems and process for producing broad molecular weight polyolefin

Catalyst systems and process for producing broad molecular weight polyolefin

A catalyst system comprising a bridged fluorenyl-containing metallocene, an unbridged metallocene, and a suitable cocatalyst and the use of such catalyst systems to produce olefin polymers. Also novel olefin polymers produced by those processes.

Implantable ambulatory electrocardiogram monitor

An implanted programmable ambulatory electrocardiography (AECG) patient monitoring device that senses and analyzes electrocardiographic signals from at least one subcutaneous precordial sensor chronically and frequently to detect electrocardiogram and physiological signal characteristics predictive of malignant cardiac arrhythmias. The device includes telemetric capabilities to communicate a warning signal to an external device when such arrhythmias are predicted.

Ultrasound blood flow/tissue imaging system

An ultrasound imaging system is provided which produces gray scale images of the anatomy simultaneous with Doppler signal processing so as to provide a single real-time image that shows not only the vascular anatomy and surrounding tissue but also flow events in the vascular compartment. A phased linear array having near-continuous focus over the scanning field provides high resolution and very small Doppler sample volumes. The system tests incoming signals from throughout the scanning field for amplitude, phase and frequency so as to determine B-mode data, motion presence and direction, and echo source velocity.

Suuren aktiivisuuden etyleenisilektiiviset metalloseenit

Catalyst system containing metallocene, process for making thereof and for polimerizing olefins

Benzofluorenylmetallocene and method of polymerization of olefins

Benzofluorenyl-containing metallocenes are disclosed along with methods for making the metallocenes. Also disclosed are methods for using the metallocenes as polymerization catalysts. In addition, polymers resulting from such polymerizations are disclosed.

Method for preparing a solid metallocene containing catalyst system useful in olefin polymerization

Process for preparing and use of a supported metallocene catalytic system

Methods are disclosed for preparing a highly active solid metallocene-containing catalyst system and its use in the polymerization of olefins. The catalyst system is prepared by creating a catalyst system solution by combining an aluminoxane with a metallocene having a substituent which has olefinic unsaturation in a suitable liquid to form a liquid catalyst system, conducting prepolymerization of an olefin in the liquid catalyst system, and separating the resulting solid metallocene-containing catalyst system from the reaction mixture. Also polymerization of olefins using the inventive solid catalyst system is disclosed.

Method of production of metallocene catalyst system

Methods are disclosed for preparing a highly active solid metallocene-containing catalyst system and its use in the polymerization of olefins. The catalyst system is prepared by creating a catalyst system solution by combining an aluminoxane with a metallocene having a substituent which has olefinic unsaturation in a suitable liquid to form a liquid catalyst system, conducting prepolymerization of an olefin in the liquid catalyst system, and separating the resulting solid metallocene-containing catalyst system from the reaction mixture. Also polymerization of olefins using the inventive solid catalyst system is disclosed.

Method for making and using a supported metallocene catalyst system

Metallocenes, method for their preparation and use

A találmány szerinti eljárással olyan metallocéneket állítanak elő,melyekben egy ciklopentadienil-tartalmú csoport egy ?-kötéssel ésugyanez a ciklopentadienil-tartalmú csoport egyik szubsztituensén átegy szén ?-kötéssel kötődik egy átmenetifémhez. Az eljárás egyiklépésében egy sajátos metallocént egy redukáló hatóanyaggalreagáltatnak, mely sajátos metallocénben legalább egy telítetlenszubsztituenst hordozó ciklopentadienil-tartalmú csoport van, ésolyan, nem hídszerkezetű metallocén, melynek szerves liganduma(ciklopentadienil)-[(ciklopentadienil)-(indenil)-(dimetil)-- metán]-tól különböző. Az előállított metallocéneket telítetlen monomerekpolimerizálásánál alkalmazzák. ŕ The process of the present invention provides metallocenes in which a cyclopentadienyl-containing group is attached to a transition metal through a carbon bond through one of the substituents on the cyclopentadienyl group. In one step of the process, a specific metallocene is reacted with a reducing agent having a cyclopentadienyl group containing at least one unsaturated substituent in the specific metallocene, a non-bridged metallocene having an organic ligand (cyclopentadienyl) - [(cyclopentenyl) - (indopenyl) - (indopenyl) methane]. The metallocenes produced are used in the polymerization of unsaturated monomers. ŕ

Processo para preparação de um metaloceno não ligado processo para polimerização de uma olefina e metaloceno não-ligado

High activity ethylene selective metallocenes, thereof containing catalyst-system, and process for polymerization of olefins

High activity ethylene selective metallocenes

High activity ethylene selective metallocenes

Silyl - crosslinked metallocenes and their use

Steering system having anti-theft capabilities

A steering system for an autonomous or semi-autonomous vehicle is provided. The steering system includes a controller that is in communication with an electric power steering system and a transmission control system. The controller is programmed to, in response to a first signal indicative of a non-verified operator and a request to operate, place the electric power steering system in a standby mode and inhibit the transmission control system from changing at least one of a transmission operational state and a transmission operational position.

Unbridged indenyl-containing metallocenes useful in olefin polymerization

Metallocenes, their production and use

Bis-Fluorenyl Metalloceneverbindungen und ihre Verwendung

BIS-FLUORENYL METALLOCENE AND ITS USE.

SE PRESENTAN METALOCENOS DE METAL DE IVB DE BIS(1METILFLUORENIL)DIFENILSIANO Y DE BIS(1-METILFLUORENIL)DIMETILESTAÑO MAS SU UTILIZACION EN LA PRODUCCION DE POLIOLEFINAS, INCLUYENDO POLIPROPILENO ISOTACTICO. DIBENILSIANO AND BIS (1-METHLFLUORENIL) DIMETHYLENE METHYLENE METHODS OF IVB ARE PRESENTED, INCLUDING THEIR USE IN THE PRODUCTION OF POLYOLEFINES, INCLUDING ISOTACTIC POLYPROPYLENE.

Bis-fluorenyylimetalloseeneja ja niiden käyttö

Bisfluorenyylimetalloseenit ja niiden käyttö

Bis-fluorenyl metallocene compounds and their use

Photopolymerizable compositions and elements for refractive index imaging

Solid photopolymerizable compositions and photosensitive elements are provided that are useful in preparing optical elements, and especially holograms. The compositions contains a polymeric binder, a liquid ethylenically unsaturated monomer, and a photoinitiator system. Typical compositions have a refractive index modulation of at least 0.005 when measured per the specified test.

Organoaluminoxy product, catalyst systems, preparation, and use

Process for preparing organoaluminiumoxy compound, the organoaluminiumoxy compound per se, catalytic system and polymerization process

Organoaluminoxy product, catalyst systems, preparation, and use

Device and method for pressure treating force-feedable material

(57)【要約】 （修正有） 【課題】 圧送可能な物質を圧力処理するための方法及 び装置を提供する。 【解決手段】 弁12が圧送可能物質源及び圧力容器30に 連結され、弁は第１、第２及び第３の位置に移動するこ とができる。弁が第１の位置にあるとき、弁に設けられ た入口ポート24が、圧力容器に開口した通路28と整列す る。弁が第２の位置にあるとき、弁体16は、通路を封止 し、弁が第３の位置にあるとき、弁に設けられた出口ポ ート26が、通路と整列する。したがって、弁を第１の位 置に移動させると、圧送可能物質を圧力容器内に圧送で き、弁を第２の位置に移動させて通路を封止し、その 間、所望の結果を達成するために、選択された期間、圧 送可能物質を選択された圧力まで加圧し、次に、弁を第 ３の位置に移動させると、処理済みの圧送可能物質を圧 力容器から送り出すことができるように構成した。

Force feedback control wheels and knobs

A force feedback wheel (16) or knob (226) is provided on a mouse (12) or other device to be manipulated by a user. The force applied to the wheel (16) can correspond with an event or interaction displayed in a host graphical environment. Force feedback is preferably provided using an actuator (112) coupled to the knob (226). The device controlled by the knob (226) can be, for example, an audio device, a video device, etc. Detent forces can be provided for the knob (226) by overlapping and adjusting ranges of closely-spaced detents in the rotary degree of freedom of the knob (226).

Control knob with multiple degrees of freedom and force feedback

The present invention provides a control knob on a device that allows a user to control functions of the device. In one embodiment, the knob is rotatable in a rotary degree of freedom and moveable in at least one transverse direction approximately perpendicular to the axis. An actuator is coupled to the knob to output a force in the rotary degree of freedom about the axis, thus providing force feedback. In a different embodiment, the knob is provided with force feedback in a rotary degree of freedom about an axis and is also moveable in a linear degree of freedom approximately parallel to the axis, allowing the knob to be pushed and/or pulled by the user. The device controlled by the knob can be a variety of types of devices, such as an audio device, video device, etc. The device can also include a display providing an image updated in response to manipulation of the knob. Detent forces can be provided for the knob by overlapping and adjusting ranges of closely-spaced detents in the rotary degree of freedom of the knob.

Method and apparatus for compensating for position slip in interface devices

Method and apparatus for compensating for position slip in interface devices that may occur between a manipulandum and a sensor of the device due to a mechanical transmission. A device position delta is determined from a sensed position of a manipulandum of an interface device. It is determined if position slip has occurred caused by a change in position of the manipulandum that was not sensed by a sensor of the interface device, typically caused by a mechanical transmission between sensor and manipulandum. If position slip has occurred, an error in the sensed position caused by the position slip is corrected by adjusting the sensed position to take into account the position slip. The adjusted position delta is used as the position of the manipulandum and the display of objects controlled by the interface device are accordingly compensated.

Vibrotactile haptic feedback devices

Vibrotactile haptic feedback devices are disclosed. For example, in one embodiment, a device includes: a mass, an actuator configured to vibrate the mass, and a coupling disposed between the actuator and the mass or between the mass and a housing, the coupling having a first configuration with a compliance and a second configuration with a compliance, the compliance of the coupling in the first configuration being different from the compliance of the coupling in the second configuration, the actuator being configured to output haptic feedback associated with the first configuration of the coupling and haptic feedback associated with the second configuration of the coupling, the haptic feedback associated with the first configuration of the coupling being different from the haptic feedback associated with the second configuration of the coupling.

Presence detection for cellular and internet protocol telephony

A telephone system supports communication with user devices over both a cellular radio network as well as over an Internet Protocol (IP) network, and enables roaming and active call handoff between cellular and IP domains. Approaches to detecting presence of a user near a suitable IP network are used in controlling transitions between the domains, for example, enabling automatic transitions between domains, and delivery of calls to a mobile user to data network devices in the vicinity of the user.

Configuration fiber-optic blood gas sensor bundle and method of making

A bundle of fiber-optic sensors that resist breakage, for use in measuring pH, CO 2 , and O 2 concentration, and a method of making the same. Three otpical fibers are enclosed in a common polyimide sheath and extend parallel to one another toward a distal end of the sensor, where they are bonded together in a mutually supportive array. At the distal end of one of these optical fibers is disposed a pellet comprising a CO 2 analyte indicator molecule codissolved within a polymer matrix. A thin reflective surface of gold foil is provided on the pellet such that incident light transmitted through the optical fiber and polymer matrix is reflected back into the optical fiber. The CO 2 polymer matrix absorbs light of a given wavelength to an extent dependent upon the level of CO 2 present. Similarly, on the distal end of a second optical fiber is disposed a pH pellet comprising a pH analyte indicator matrix with a thin reflective gold foil attached for reflecting light that has passed through the pH analyte indicator matrix back into the optical fiber. The pH analyte indicator matrix absorbs light of a given wavelenth to an extent dependent upon the hydrogen ion concentration (pH level) of a surrounding fluid. The third optical fiber is used for measuring oxygen concentration. An O 2 indicator matrix covers the distal ends of at least two of the three optical fibers; however, at least a portion of the pH optical fiber and the pH pellet are free of the O 2 indicator matrix, which is hydrophobic. The oxygen indicator matrix phosphoresces for an interval of time that decreases in proportion to the surrounding oxygen gas concentration. The phosphorescent and reflected light signals are transmitted to light detectors through the optical fibers for comparison to reference signals, so that the analyte concentrations can be determined.

Leadless implantable sensor assembly and a cardiac emergency warning alarm

A leadless implantable cardiac arrhythmia alarm is disclosed which continuously assesses a patient's heart function to discriminate between normal and abnormal heart functioning and, upon detecting an abnormal condition, generates a patient-warning signal. The alarm is capable of sensing impedance measurements of heart, respiratory and patient motion and, from these measurements, generating an alarm signal when the measurements indicate the occurrence of a cardiac arrhythmia. Because it requires no external leads or feedthrough connectors, the hermetically-sealed patient alarm is minimally invasive and results in reduced trauma to a patient.

Compositions and methods for induced brown fat differentiation

The invention provides methods and compositions for inducing brown fat cell differentiation through modulation of both Prdmlβ and C/EBPβ activity and/or expression. Also provided are methods for preventing or treating obesity or an obesity related disorder in a subject through stimulation of both Prdmlβ and C/EBPβ expression and/or activity. Further provided are methods for identifying compounds that are capable of modulating both Prdmlβ and C/EBPβ expression and/or activity.

Compositions,kits, and methods for identification, assessment, prevention, and therapy of metabolic disorders

The invention provides methods and compositions for selectively promoting anti- metabolic disorder activity over classical PPAR gamma activation through modulation of PPAR gamma phosphorylation (e.g., Ser-273 phosphorylation of murine peroxisome proliferator activated receptor gamma (PPAR gamma) 2 or a corresponding serine residue in a murine PPAR gamma 2 homolog, including a human). Also provided are methods for preventing, treating, or predictiving responsiveness of therapies for metabolic disorders in a subject through selective inhibition of such PPAR gamma phosphorylation. Further provided are methods for identifying compounds that are capable of modulating such PPAR gamma phosphorylation.

Compositions and methods for brown fat induction and activity using fndc5

The invention provides compositions and methods for brown fat induction and activity through modulation of Fndc5 activity and/or expression. Also provided are methods for preventing or treating metabolic disorders in a subject through modulation of Fndc5 activity and/or expression. Further provided are methods for identifying compounds that are capable of modulating Fndc5 activity and/or expression.

Compositions and methods for modulating thermogenesis using pth-related and egf-related molecules

The present invention provides compositions and methods for modulating thermogenesis and related activities by modulating ΡΤΉ-related and EGF-related expression and activity. Also provided are methods for preventing or treating metabolic disorders in a subject through modulation of PTH-related and EGF-related expression and activity.

Methods for identification, assessment, prevention, and treatment of metabolic disorders using pm20d1 and n-lipidated amino acids

The present invention relates to methods for identifying, assessing, preventing, and treating metabolic disorders and modulating metabolic processes using PM20D1 and N- lipidated amino acids.

Fastening system for a disposable absorbent garment

A disposable absorbent garment (10) of the type having opposed waistband portions (14 ) separated by an intermediate portion (16), comprises a breathable elastomeric nonwoven fabric outer cover (12) having an absorbent structure (32) integral therewith, including a liquid-impervious baffle (36), a liquid-pervious bodyside liner (34), and an absorbent core (38) therebetween. The absorbent structure (32) preferably forms an insert attached to the outer cover (12) without restricting the stretchability thereof. The garment (10) has a generally asymmetrical hourglass profile with leg cut-out openings (18) converging together to define a narrow crotch with front (28) and rear (30) panels on either side thereof, having pairs of front (20, 22) and rear (24, 26) ear portions, respectively. Laterally-opposed pairs of rear fastener members (42, 44) and front (46, 48) fastener members extend across the rear ear portions (20, 22) and front ear portions (24, 26), respectively. Longitudinally opposed pairs (42, 46; 44, 48) of the fastener members are engagable with one another, forming substantially full-length closures from the waistband (14) to each leg opening (18) of the garment (10). Each fastener member (42, 46; 44, 48) comprises at least two spaced snap elements (50A, 50B), representing primarily fixed-point closures, separated by an abutment surface (52, 54, 56, 58) presenting a secondary load-bearing closure, such as a cohesive adhesive strip (64), for effecting and maintaining a substantially continuous closure between the primary closures formed by the snap elements (50A, 50B) when longitudinally opposed pairs (42, 46; 44, 48) of the fastener members are fastened together about the body of a wearer, providing full-length, fixed-point fastening substantially from waist to leg of the wearer, resulting in a neat, trim fit and appearance.

Extruded polymer foams containing brominated fatty acid-based flame retardant additives

Root preferential promoter

The present invention is directed to promoter fragments isolated from maize and particularly to a 4.7 kbp upstream promoter region designated ZRP2 of a ZRP2 genomic DNA clone, specific fragments thereof designated ZRP2(2.0) and ZRF2(1.0) and functional equivalents thereto. The promoter has particular utility in driving root preferential expression of heterologous genes that impart increased agronomic, horticultural and/or pesticidal characteristics to a given plant. This invention is also directed to DNA molecules including said promoters and transformed plant tissue including a DNA molecule comprising a promoter of the invention operably linked to a heterologous gene or genes and the seeds thereof.

Inert gas delivery for reflow solder furnaces

An apparatus and method of reflow soldering electronic components, preferably to printed circuit boards, in an inert atmosphere to reduce solder defects and the need for flux or cleaning wherein the inert atmosphere is provided from a source of inert gas through several distribution lines which parallel the conveyor belt of a reflow solder furnace and supply each end of porous sintered metal diffuser tubes situated above the conveyor belt, as well as gas knives situated in baffle compartments at the inlet and outlet of the reflow solder furnace to strip barrier layers of oxygen atmosphere from the electronic components and preclude ingress of oxygen atmosphere into the reflow solder furnace.

Compositions and methods for brown fat induction and activity using fndc5

The invention provides compositions and methods for brown fat induction and activity through modulation of Fndc5 activity and/or expression. Also provided are methods for preventing or treating metabolic disorders in a subject through modulation of Fndc5 activity and/or expression. Further provided are methods for identifying compounds that are capable of modulating Fndc5 activity and/or expression.

Methods for identification, assessment, prevention, and treatment of metabolic disorders using pm20d1 and n-lipidated amino acids

The present invention relates to methods for identifying, assessing, preventing, and treating metabolic disorders and modulating metabolic processes using PM20D1 and N- lipidated amino acids.

Diaper or absorbent article with tensioning attachment

An absorbent or other article including a tensioning system for joining portions of the article together. The system includes a plurality of hook members attached on one portion of the article, and a plurality of loop members attached to a loop panel wherein the loop panel may be intermittently attached to the article.

Dispensing closure with twist collar

A dispensing closure is provided for a container (22) and includes a base (24) for being mounted to the container over the container opening. An actuator (60) is mounted on the base (24) and is tiltable between a closed position and an open position. A ring (25) is mounted on the base (24) for rotation relative to the base (24) and actuator (60). The ring (25) and base (24) together cooperatively define a cam drive means (131, 151; 132, 152) for effecting the tilting of the actuator (60).

Eluting medical devices

The invention is directed to eluting medical devices that enable consistent “on-demand” delivery of therapeutic agents to a vessel. The medical device of the current invention comprises an expandable member, a hydrophilic coating comprising at least one therapeutic agent about the expandable member or structural layer and an outer sheath with a variably permeable microstructure. The design and methods disclosed herein ensures that therapeutic agent delivery occurs essentially only during expansion of the expandable member, minimizing coating and/or therapeutic agent loss to the bloodstream and providing controlled delivery to the treatment site.

Retractable sheath devices, systems, and methods

The invention is directed to delivery medical devices that enable consistent “on-demand” delivery of therapeutic agents to a vessel. The medical device of the current invention comprises retractable sheath comprising neckable elements. The medical device of the current invention comprises an expandable member, a hydrophilic coating comprising at least one therapeutic agent about the expandable member or structural layer and a retractable outer sheath with a selectively permeable microstructure. The design and methods disclosed herein ensures that therapeutic agent delivery occurs essentially only during retraction of the outer sheath, minimizing coating and/or therapeutic agent loss to the bloodstream and providing controlled delivery to the treatment site.

Detection of cardiac arrhythmias using correlation of a cardiac electrical signals and temporal data compression

A method and apparatus for detecting cardiac arrhythmias in a patient's heart is disclosed. The monitoring method and apparatus sense cardiac electrical signals when the heart is functioning in a known cardiac state, then characterize this known cardiac state by storing a temporally compressed template of time sequence samples. The method and apparatus allow testing during multiple different cardiac states and provide for storage of templates associated with each state. Subsequently, when the heart is functioning in an unknown cardiac state, the method and apparatus monitor cardiac electrical signals by temporally compressing samples and scan correlating these samples with the previously stored template sequences to derive correlation coefficients. The method and apparatus then use these correlation coefficients to characterize cardiac function.

Methods and compositions for mitochondrial replacement therapy

The invention features methods, kits, and compositions for mitochondrial replacement in the treatment of disorders arising from mitochondrial dysfunction. The invention also features methods of diagnosing neuropsychiatric (e.g., bipolar disorder) and neurodegenerative disorders based on mitochondrial structural abnormalities.

APPARATUS AND METHOD FOR DEPOSITING IN THE GASEOUS PHASE BY CHEMICAL PROCESS

L'invention concerne le dépôt en phase gazeuse par processus chimique.L'appareil comprend une chambre de revêtement chauffée (20), un conduit d'amenée de gaz de revêtement (22) disposé sur une longueur de ladite chambre de revêtement de telle manière que ledit gaz de revêtement soit préchauffé et un conduit de répartition de gaz (18) disposé autour du conduit d'amenée (22) pour répartir vers ladite chambre (20) le gaz de revêtement préchauffé.L'invention permet de former sur un substrat des revêtements plus uniformes. The invention relates to gas deposition by chemical process. The apparatus comprises a heated coating chamber (20), a coating gas supply conduit (22) disposed along a length of said coating chamber in such a manner that said coating gas is preheated and a gas distribution duct (18) arranged around the supply duct (22) for distributing the preheated coating gas to said chamber (20). The invention makes it possible to form on a substrate more uniform coatings.

WATER RIFLE TOY.

Le fusil à eau jouet à pressurisation d'air comprend un boîtier muni d'une poignée ou d'une crosse en prolongement, d'une détente et d'un fût. Il comporte un réservoir amovible de stockage d'eau 13 muni d'un orifice unique 33 à travers lequel passent le liquide et le gaz de pressurisation, des moyens de fixation 35 sont prévus pour relier ledit réservoir 13 au boîtier 3 du fusil à eau en réalisant une étanchéité à l'eau et des moyens de pressurisation 17, 15 sont aptes à refouler de l'air de pressurisation dans le réservoir 13. Application à des fusils à eau jouets dont la pression d'eau est mise en œuvre par une pompe à air intégrée au jouet. The air pressurized toy water rifle comprises a housing equipped with a handle or an extended butt, a trigger and a barrel. It comprises a removable water storage tank 13 provided with a single orifice 33 through which pass the liquid and the pressurization gas, fixing means 35 are provided to connect said tank 13 to the housing 3 of the water gun in providing water tightness and pressurization means 17, 15 are able to deliver pressurization air into the tank 13. Application to toy water guns, the water pressure of which is implemented by a pump air integrated into the toy.

Patent FR2666645B1

WATER GUN TOY WITH PINCH GASCHET AND DOUBLE TANK.

Le fusil à eau comprend un boîtier muni d'une poignée ou crosse en prolongement, d'une gâchette et d'un fût. Il comporte un réservoir de réserve d'eau 38 relié audit boîtier et muni d'un orifice 28 pour y ajouter ou y enlever de l'eau et une aération 19, un réservoir de réserve d'eau pressurisée 3 relié audit boîtier 60 et muni d'un orifice unique 39, ainsi que des moyens de pompage 33, 34 aspirant de l'air et/ou de l'eau dudit réservoir de réserve 38 et les refoulant dans le réservoir de réserve pressurisé 3, ainsi qu'une pluralité de clapets anti-retour 30, 11, 43 isolant les moyens de pompage du réservoir de réserve 38 et du réservoir pressurisé 3. Application à des fusils à eau jouets comportant à la fois un réservoir pressurisé, des moyens de pressurisation et un réservoir d'eau de grande capacité. The water rifle comprises a housing fitted with a handle or extended butt, a trigger and a barrel. It comprises a water reserve tank 38 connected to said housing and provided with an orifice 28 for adding or removing water therefrom and an aeration 19, a pressurized water reserve tank 3 connected to said housing 60 and provided a single orifice 39, as well as pumping means 33, 34 sucking air and / or water from said reserve tank 38 and discharging them into the pressurized reserve tank 3, as well as a plurality of non-return valves 30, 11, 43 isolating the pumping means from the reserve tank 38 and from the pressurized tank 3. Application to toy water guns comprising both a pressurized tank, pressurization means and a water tank large capacity.

SHUTDOWN INSTALLATION OF A NUCLEAR REACTOR

APPARATUS AND METHOD FOR GAS PHASE DEPOSITION THROUGH CHEMICAL PROCESS

Mouse interface device for providing force feedback

A force feedback mouse interface device as shown in the Figure connected to a host computer and providing realistic force feedback to a user. The mouse interface device (11) includes a mouse object (12) and a linkage (40) coupled to the mouse that includes a plurality of members (46, 50) rotatably coupled to each other in a planar closed-loop linkage, two of the members coupled to ground and rotatable about the same axis (52). Two actuators (64), preferably electromagnetic voice coils, provide forces in the two degrees of freedom of the planar workspace of the mouse object. Each of the actuators includes a moveable coil portion (64a) integrated with one of the members of the linkage and a magnet portion (90a) coupled to the ground surface through which the coil portion moves. At least one sensor (62) is coupled to the ground surface that detects movement of the linkage and provides a sensor signal including information from which a position of the mouse object in the planar workspace can be determined.

Action figure with the ability to shoot water

ABSTRACT OF THE DISCLOSURE The present invention is an action figure with the ability to shoot water by means of an air pressurized water chamber. The action figure includes a body which is at least partially hollow and at least one body orifice. A water storage reservoir is connected to the body and it has orifice for adding water thereto. It is also connected to a pressurizing means. The pressurizing means is for pressurizing the reservoir with air after water has been added and is attachable to the body, the reservoir or both. There is an avenue of release which runs from the reservoir to a nozzle and a water release means for regulating the fluid flow through the avenue of release. The water release means is operably connected to the avenue of release and extends outwardly therefrom to permit manual operation. A nozzle at the end of the avenue of release controllably releases water when the water release means is actuated. The action figure may be a mammal or other character/ with the pressurizing means being embodied partially in an appendage and the nozzle being located in an appendage. The water storage reservoir may be within the body of the action figure, or externally located and connected thereto. If external, it may be detachable or non-detachable.

MULTI-CHAMBER DISPENSER CONTAINER AND CLOSING DEVICE

Data transfer apparatus for communicating between a peripheral and a bus control unit.

Data transfer apparatus communicating between a peripheral and a bus control unit

A data transfer apparatus (219) is intended for a radio telephone peripheral using a time-division multiplexing databus for communication with a bus control unit of the radio telephone (201) coupled with the peripheral devices external to the radio telephone and with other devices for the input of information by the user, for example a cellular mobile radio telephone handset (203), to the central processor and to the speech processor (207) of the radio telephone. The data transfer apparatus produces timeslots within frame formats, where the information is despatched over the databus. The message which is despatched in a timeslot of a peripheral device to the bus control device is used to determine, or manage, bus access conflict. Resolution of the bus access conflict when powering up the peripheral fixes the priority, with respect to other data transfer apparatuses, with which a data transfer apparatus of a peripheral device can access the bus during normal operation.

PROCESS FOR CLEANING THE INTERNAL PASSAGE OF A BLADE AND BLADE CLEANED ACCORDING TO THIS PROCESS

L'invention concerne un procédé de nettoyage d'un passage interne d'une pale de turbine à gaz qui a été exposée aux conditions de fonctionnement de la turbine, qui comprend immersion de la pale dans un milieu à base d'hydroxyde inorganique à une température supérieure à la température ambiante et à la pression atmosphérique pendant une durée permettant de retirer les matières étrangères du passage interne, ainsi qu'une pale nettoyée par ledit procédé. The invention relates to a method of cleaning an internal passage of a gas turbine blade which has been exposed to the operating conditions of the turbine, which comprises immersing the blade in a medium based on inorganic hydroxide at a temperature. temperature above ambient temperature and atmospheric pressure for a period of time allowing foreign matter to be removed from the internal passage, as well as a blade cleaned by said method.

Metal halide gas generator for chemical vapor deposition apparatus, has O-ring seal provided between flange region of housing and base of generator

A housing (30h) has metallic charge that reacts with halide gas, to produce a metal halide gas. The housing has an flange region provided with a cooling passage. An O-ring seal (33) comprising acid resistant polymeric material, is provided between a base (35) and the flange region. A heating device heats the aluminum or silicon pellets accommodated in the generator, to a reaction temperature. An Independent claim is also included for air leakage reducing method.

Patent FR2680256B1

Flux transmission connectors and systems, flux disambiguation, and systems and methods for mapping flux supply paths

Controlling vibrotactile sensations for haptic feedback devices

Methods and pharmaceutical compositions for inhibiting tumour cell growth

Methods for inhibiting proliferation of a PPARη-responsive hyperproliferative cell using PPARη agonists are described. Pharmaceutical compositions as well as methods for diagnosing and treating a PPARη-responsive hyperproliferative cell are also described.

Multiple stroke tool

Halide gas generator; chemical vapour deposition

Chemical vapor deposition is performed with external metal halide gas generators that reduce leakage of air into the generators so as to improve efficiency of use of the metal charge residing in each generator. The generator 30 comprises a base, a housing having a metallic charge for reaction with a halide gas to produce a metal halide gas. The housing has a region disposed on the base, there being an air-tight seal 33 of polymeric material disposed between the region and the base and the region has a fluid passage 30c for cooling the region. In addition a heating device 46 is provided for heating the metallic material to reaction temperature. Typical halides produced are aluminium chloride for producing aluminide coatings.

Software Center and Highly Configurable Robotic Systems for Surgery and other uses

METHOD AND APPARATUS OF DATA TRANSFER WITH PRIORITY FOR A RADIO TELEPHONE PERIPHERAL.

Closure with multiple axis bistable hinge structure

Metallocenes containing 9-substituted fluorenyl compounds and the use of these metallocenes

Method and apparatus for absorbing thermal energy

DEVICE FOR PRODUCING A HIGH-PRESSURE WATER JET

Fastening system for disposable diaper with disposability feature

There is disclosed a disposable diaper in which the waistband is closed by a mechanical fastener. A second fastener means is included and positioned on the article to enable rolling or folding the garment after use and thereby secure it in a neat bundle for disposal. In the disclosed embodiments, the mechanical fastener is comprised of hook tabs at the rear waistband which engage a patch of loop material adhesively bonded on the front waistband. The second fastener means of the disclosed embodiments utilizes the tabs which engage a compatible component on the garment placed in the same half portion with the tabs. The disclosed species of the second (disposability) fastener means include: (1) tabs comprised of a hook component on one surface and loop component on the opposite surface thereof: or (2) tabs comprised of a hook component and a loop component on the outer surface in the same (rear) half of the garment; or (3) tabs comprised of a hook component and a loop component on the outer surface at the rear half of the cover in the region of the ears which is comprised of either the loop material mounted on the garment outer surface or is a non-woven material portion configured to function with the hook component and perform the secondary fastening function: or (4) tabs comprised of a hook component area and a pressure-sensitive adhesive area, the latter adhesively fastening the tabs to the rear half of the outer polymer cover sheet of the garment: or (5) tabs comprised of a hook component and transverse interlocking slots in the tabs, which link the ends of the rear waistband around the rolled garment to secure it for disposal.

Newborn's growth adjustable absorbent diaper having variable overlapping and non-overlapping ears

A growth adjustable diaper for newborn babies is adjustable in length by use of a foldable absorbent panel at the front edge of the diaper and is adjustable about the waist of the baby by means of ear members that can overlap and attach to each other or not overlap and attach to the front section of the diaper. Cushion barriers are provided at the crotch section and back waist edge to protect the newborn's sensitive, tender skin.

Software center and highly configurable robotic systems for surgery and other uses

Telerobotic, telesurgical, and/or surgical robotic devices, systems, and methods employ surgical robotic linkages that may have more degrees of freedom than an associated surgical end effector n space. A processor can calculate a tool motion that includes pivoting of the tool about an aperture site. Linkages movable along a range of configurations for a given end effector position may be driven toward configurations which inhibit collisions. Refined robotic linkages and method for their use are also provided.

Pgc-1beta, a novel pgc-1 homologue and uses therefor

Mattress and bed deck cover

The present invention relates to a cover for a mattress and bed deck. More particularly, the present invention relates to a mattress and bed deck cover for an adjustable bed that reduces the exposure of the mattress and bed deck to unsanitary conditions.

Eluting medical devices

The invention is directed to eluting medical devices that enable consistent "on-demand" delivery of therapeutic agents to a vessel. The medical device of the current invention comprises an expandable member, a hydrophilic coating comprising at least one therapeutic agent about the expandable member or structural layer and an outer sheath with a variably permeable microstructure. The design and methods disclosed herein ensures that therapeutic agent delivery occurs essentially only during expansion of the expandable member, minimizing coating and/or therapeutic agent loss to the bloodstream and providing controlled delivery to the treatment site.

Novel fdrg protein and nucleic acid molecules and uses therefor

Novel FDRG polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length FDRG proteins, the invention further provides isolated FDRG fusion proteins, antigenic peptides and anti-FDRG antibodies. The invention also provides FDRG nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a FDRG gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

Method of selectively monitoring trace constituents in plating baths