28-09-2011 дата публикации
Номер: CN0102198113A
Принадлежит:
The invention discloses a preparation process of a quetiapine fumarate slow release tablet, belonging to the technical field of preparing medicinal slow/controlled-release preparations. In the process, a soluble slow-release accessory is used as a retarding agent, and slow-release particles are prepared by using a fusion-method solid dispersion technology and are tabletted. The quetiapine fumarate slow release tablet is the slow-release matrix tablet prepared by using a process of externally covering the tablet with a quick-release thin-film coating. The quetiapine fumarate in the invention has the in-vitro release characteristics as follows: after 750ml of 0.1NHCl is added for 2 hours, the release amount of quetiapine fumarate within 0-2 hours is 0-35%, and after 250ml of K3PO4 is added, the release amounts of the quetiapine fumarate within 2-8 hours, 8-12 hours and 12-20 hours are respectively 35-60%, 60-80% and 80-100%. The process has the advantages of simple and safe flow, controllable ...
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