METHODS AND APPARATUS FOR TESTING DISRUPTION OF A VAGAL NERVE

Method and apparatus for disrupting a gastric vagal nerve in the gastroesophageal region and testing the function and disruption of the vagal nerve. In one example embodiment, a treatment device applies ultrasound at a high energy level, such as high intensity focused ultrasound, to a vagal nerve to disrupt it and then ultrasound at a lower energy level to another portion of the vagal nerve, preferably further from the stomach, so as to stimulate the vagal nerve. Alternative ways to test the function or disruption of the vagal nerve involve using PCP-GABA, a pancreatic polypeptide, pressure changes inside the stomach, the gastric mucusol pH, a dye agent in the stomach, and other tests. 1. A system for testing the function of a gastric vagal nerve comprising:an elongate device adapted to be inserted into an esophagus; andan energy delivery device located on the elongate device, the energy delivery device being adapted to deliver energy from within the esophagus to a vagal nerve branch.2. The system of further comprising a pressure transducer adapted to be inserted into the stomach claim 1 , the pressure transducer also adapted to measure the pressure in the stomach.3. The system of wherein the energy delivery device is adapted to deliver energy at two or more energy levels including a high energy level sufficient to disrupt the vagal nerve branch and a low energy level sufficient to stimulate the vagal nerve branch without disrupting the vagal nerve branch.4. The system of further comprising an electrical stimulator adapted to apply an electrical stimulus to the vagal nerve.5. The system of further comprising a pressure transducer adapted to be inserted into the stomach and to measure the pressure in the stomach.6. The system of further comprising:a pressure transducer adapted to be inserted into the stomach and to measure the pressure in the stomach; anda processor adapted to compare the pressure measured by the pressure transducer in the stomach before the ...

Bus Stop Systems and Methods of Scheduling

Methods of providing services to individual and methods of manufacturing items are described. Data structures to represent priority values for those individuals or items are also described. By ascribing priority values to a set of items, those items can be grouped based on those priority values. Once grouped based on priority values, the items within each group can be manufactured according to group priority as well as according to the characteristics of each item to be manufactured within that group. The same concept applies to providing services to individuals.

REMOTE CONTROL OF STROKE AND FREQUENCY OF PERCUSSION APPARATUS AND METHODS THEREOF

This disclosure describes methods and systems for remote control of stroke length and frequency of percussion apparatus, such as a rock hammer drill. At a high level, the hammer drill is allowed to stay at a default low stroke length and high frequency to avoid applying excessive cyclic stress to the housing of the hammer drill and can be controlled to operate at a long stroke length and low frequency when the hammer drill has engaged the target material. The long stroke length and low frequency during operation can be initiated when a sufficient forward feed pressure is provided. While the hammer drill is idling or retracting, the forward fee pressure is not sufficient for the long stroke length operation and thus the drill operates at the default state and at a safe stress level to avoid premature damage. 1. A method for controlling a percussion apparatus for an extended life of operation , the method comprising:operating the percussion apparatus at a first stroke length and at a first frequency, wherein the first stroke length and the first frequency generate a low stress level to reduce fatigue in the percussion apparatus;receiving a user selection for a second stroke length and a second frequency, wherein the second stroke length is longer than the first stroke length and the second frequency is lower than the first frequency such that a high stress level increases fatigue in the percussion apparatus when the percussion apparatus has yet engaged with an operation target;providing a feed forward pressure to a sliding selector controlling the piston hammer stroke length and the frequency according to the user selection and in response to an actuation input;in response to the feed forward pressure lower than a threshold level, maintaining the first stroke length and the first frequency; andin response to the feed forward pressure higher than the threshold level, increasing the first stroke length to the second stroke length and reducing the first frequency to the ...

BONE AND JOINT STABILIZATION DEVICE ATTACHMENT FEATURES

Components and associated methods of manufacture or assembly and/or use for bone and joint stabilization devices or systems are described. The components include features for device introduction, attaching a distal anchoring foot or threaded screw to an elongate spring-type member, anchoring head features for stabilizing position of the elongate member when engaged within the head and/or digital or electronic methods for tensioning the subject devices. 112-. (canceled)13. A medical device comprising:an anchoring head including first and second teeth, the teeth configured for one-way advancement and locking with a spring member when received through the anchoring head, the teeth directly across from one another, each tooth supported by a deflectable support column connected to a body of the anchoring head adjacent a bottom surface of the anchoring head;the body of the anchoring head including slots configured to maintain the spring in a stable fore-aft position between the teeth together with the columns; andthe support columns each having an inner surface that is within about 5 degrees of a vertical axis of the body to work with the slot in constraining movement of the spring member.14. The medical device of claim 13 , wherein about 0.005 inch or less fore-aft clearance is provided by the slots for the spring member.15. The medical device of claim 13 , wherein the anchoring head includes only the first and second teeth.16. The medical device of claim 13 , where the inner surface of each support column has a length of at least about 40% of an overall height of the anchoring head.17. The medical device of claim 13 , wherein the anchoring head comprises PEEK polymer material and the stable fore-aft position is along a centerline between the teeth.18. The medical device of claim 13 , wherein each tooth is configured to contact the elongate member at an initial contact angle between about 20 and about 30 degrees claim 13 , with the initial contact angle transitioning to ...

Modulating ptpn2 to increase immune responses and perturbing gene expression in hematopoietic stem cell lineages

The present invention relates, in part, to methods of treating a subject with a condition that would benefit from an increased immune response comprising administering to the subject a therapeutically effective amount of an agent that inhibits PTPN2. The present invention also provides methods and compositions for perturbing gene expression in hematopoietic cell lineages.

ROD AND CASING HANDLER

A rod and casing handler according to embodiments of the present disclosure includes a boom mount that is configured to be coupled to a boom. A clamp mounting structure is coupled to the boom mount and has a central portion, a first arm, and a second arm, where each arm extends from the central portion. A first clamp is coupled to the first arm and includes a first set of actuatable tongs and a first removable saddle plate. A second clamp is coupled to the second arm, and it includes a second set of actuatable tongs and a second removable saddle plate. The first removable saddle plate has a first arcuate surface sized and shaped to correspond to a cylindrical body having a first diameter, and the second saddle plate has a second arcuate surface sized and shaped to correspond to a cylindrical body having a second diameter, the first and second arcuate surfaces are disposed to hold the first cylindrical body in coaxial alignment with the second cylindrical body. 1. A handler , comprising:a boom mount configured to be coupled to a boom;a clamp mounting structure coupled to the boom mount and having a central portion and a first arm and a second arm, each arm extending from the central portion;a first clamp coupled to the first arm and comprising a first set of actuatable tongs and a first saddle plate having a first arcuate surface sized and shaped to correspond to a first cylindrical body having a first diameter; anda second clamp coupled to the second arm and comprising a second set of actuatable tongs and a second saddle plate having a second arcuate surface sized and shaped to correspond to a second cylindrical body having a second diameter, wherein the first diameter is greater than the second diameter and the first arcuate surface and the second arcuate surface are disposed to hold the first cylindrical body in coaxial alignment with the second cylindrical body.2. The handler of wherein the clamp mounting structure has a first axis of rotation with respect to the ...

Efficient short message compression

A method for compressing a short message includes receiving a short message that includes a plurality of text strings for compression, dividing the short message into one or more sub-blocks, where a number of text strings in each of the one or more sub-blocks is less than or equal to a predetermined number. The method also includes compressing each of the one or more sub-blocks by identifying a type of a first text string, identifying a code representing the type, determining whether the first text string exists in a library, upon determining that the first text string exists in the library, determining an index corresponding to the first text string, extracting a predetermined number of least significant digits of the index, and replacing the first text string in that sub-block with the code and the extracted predetermined number of least significant digits of the index.

MEDICAL DEVICE AND METHODS FOR MAKING AND USING SAME

A medical device having an annular body configured to transition from a delivery configuration to a deployed configuration. The body having a plurality of openings each having a mid-portion with a width in a direction transverse to a long dimension of the opening that is greater than widths of a remainder of the opening in the deployed configuration. An end portion of the annular body extending towards a longitudinal axis of the medical device in the deployed configuration. The medical device tapers from a proximal end towards a distal end in the deployed configuration, when viewed in a direction transverse to the longitudinal axis. 1. A medical device comprising:an annular body configured to transition from a delivery configuration to a deployed configuration, the body comprising a plurality of openings each having a mid-portion with a width in a direction transverse to a long dimension of the opening that is greater than widths of a remainder of the opening in the deployed configuration;an end portion of the annular body extending towards a longitudinal axis of the medical device in the deployed configuration,wherein the medical device tapers from a proximal end towards a distal end in the deployed configuration, when viewed in a direction transverse to the longitudinal axis.2. The medical device of claim 1 , wherein members forming the plurality of openings are biased toward an expanded claim 1 , deployed configuration.3. The medical device of claim 1 , wherein a plurality of struts forming the plurality of openings comprises a first strut adjacent to a second strut claim 1 , the first strut and the second strut being coupled together at a hinged region.4. The medical device of claim 1 , wherein the annular body is formed of a shape memory material.5. The medical device of claim 1 , further comprising a plurality of tines extending from the annular body.6. The medical device of claim 1 , further comprising a radiopaque marker.7. The medical device of claim 1 , ...

CLOSURE DEVICE AND METHODS FOR MAKING AND USING THEM

A medical device that includes a plurality of strut members forming a plurality of generally diamond-shaped openings, the plurality of strut member being configured to form an annular shaped structure with the generally diamond-shaped openings extending generally longitudinally relative to a longitudinal axis of the medical device. A plurality of tissue engaging portions are associated with the plurality of struts, with each tissue engaging portion extending towards the longitudinal axis in a deployed configuration. 120.-. (canceled)21. A medical device comprising:a plurality of members forming a body, the body being configured to transition from a delivery configuration to a deployed configuration, the plurality of members forming a plurality of openings with a long axis extending generally longitudinally relative to a longitudinal axis of the medical device; anda plurality of end portions disposed at a distal portion of the medical device, each end portion extending generally towards the longitudinal axis in the deployed configuration.22. The medical device of claim 21 , wherein each opening has a mid-portion having a width in a direction transverse to the long axis of the opening greater than widths of a remainder of the opening.23. The medical device of claim 21 , wherein each end portion extends away from the opening to engage tissue disposed adjacent to the tissue engaging portion.24. The medical device of claim 21 , wherein the plurality of end portions are disposed substantially symmetrically about the longitudinal axis.25. The medical device of claim 21 , wherein the openings are biased toward an expanded claim 21 , deployed configuration.26. The medical device of claim 21 , wherein two adjacent struts of the plurality of struts are coupled together at a hinged region.27. The medical device of claim 21 , wherein the medical device includes 5 or more openings.28. The medical device of claim 21 , wherein the plurality of end portions extend distally from a ...

CLOSURE DEVICE AND METHODS FOR MAKING AND USING THEM

A medical device that includes a plurality of strut members forming a plurality of generally diamond-shaped openings, the plurality of strut member being configured to form an annular shaped structure with the generally diamond-shaped openings extending generally longitudinally relative to a longitudinal axis of the medical device. A plurality of tissue engaging portions are associated with the plurality of struts, with each tissue engaging portion extending towards the longitudinal axis in a deployed configuration. 1. A medical device comprising:a plurality of strut members forming a plurality of generally diamond-shaped openings, the plurality of strut member being configured to form an annular shaped structure with the generally diamond-shaped openings extending generally longitudinally relative to a longitudinal axis of the medical device; anda plurality of tissue engaging portions, each tissue engaging portion extending towards the longitudinal axis in a deployed configuration.2. The medical device of claim 1 , wherein adjacent struts of the plurality of struts form a curved apex.3. The medical device of claim 1 , wherein each generally diamond-shaped opening has a mid-portion having a width in a direction transverse to a longitudinal axis of the generally diamond-shaped opening greater than widths of a remainder of the generally diamond-shaped opening.4. The medical device of claim 1 , wherein each tissue engaging portion extends away from the generally diamond-shaped opening to engage tissue disposed adjacent to the tissue engaging portion.5. The medical device of claim 1 , wherein the plurality of tissue engaging portions are disposed substantially symmetrically about the longitudinal axis.6. The medical device of claim 1 , wherein the generally diamond-shaped openings are biased toward an expanded claim 1 , deployed configuration.7. The medical device of claim 1 , wherein two adjacent struts of the plurality of struts are coupled together at a hinged region ...

Closure device and methods for making and using them

A method that includes locating an opening in tissue by advancing a member through the opening in tissue and following locating the opening, deploying a medical device to aid with sealing the opening. The medical device includes a plurality of strut members forming a plurality of generally diamond-shaped openings, the plurality of strut member being configured to form an annular shaped structure with the generally diamond-shaped openings extending generally longitudinally relative to a longitudinal axis of the medical device. The medical device further includes a plurality of tissue engaging portions associated with the plurality of struts, each tissue engaging portion being disposed between adjacently positioned generally diamond-shaped openings.

CLOSURE SYSTEM AND METHODS OF USE

A closure system and methods of use are provided for use in sealing an opening in a body tissue, such as a vascular puncture site. A method of closing the opening in the body tissue can be performed with the closure system having a closure clip. The method can include positioning the closure clip in a first closure clip position adjacent to the opening in the body tissue such that a plurality of spikes of the closure clip are inserted into the tissue at a location outward from a central axis of the opening. Subsequently, the closure clip can be positioned in a second closure clip position such that the plurality of spikes are pulled inward toward the central axis of the opening so as to pull the tissue between the opening and each of the spikes together and close the opening. 1. A closure component configured to cooperate with tissue and be delivered from a housing , the closure component comprising:at least two distally extending legs;a narrow region proximal the at least two distally extending legs; anda fastener disposed relative to the at least two distally extending legs, the fastener configured to direct opposing legs of the at least two distally extending legs inwardly towards one another;wherein the closure component has a deployed configuration where the opposing legs of the at least two distally extending legs are directed inwardly towards one another to engage and cooperate with the tissue and where a portion of the closure component at the narrow region has given way suddenly under strain to separate the closure component from the housing.2. The apparatus of wherein said legs further comprise at least one engagement means.3. The apparatus of claim 2 , wherein the engagement means comprises barbs.4. The apparatus of claim 1 , wherein the proximal end of the bioabsorbable clip has a substantially square cross sectional shape.5. The apparatus of claim 1 , wherein the narrow region is proximal a proximal end of the fastener.6. The apparatus of claim 1 , ...

Compositions and methods for identification, assessment, prevention, and treatment of t-cell exhaustion using cd39 biomarkers and modulators

The present invention is based on the identification, of compositions and methods for the identification, assessment, prevention, and treatment of T-cell exhaustion using CD39 biomarkers and modulators.

Flameless Glycol Heater

A fluid heating process which does not utilize an open flame, heat is created by a rotating prime mover(s) driving a hydraulic heat generator. Heat is also collected from the prime mover cooling system, and any exhaust heat generated by the prime mover. The heat energy is collected from all these sources, and transmitted through heat exchangers to generate a hot fluid, which can be used to heat other fluids and used for any application where heat is required.

MODULATING dsRNA EDITING, SENSING, AND METABOLISM TO INCREASE TUMOR IMMUNITY AND IMPROVE THE EFFICACY OF CANCER IMMUNOTHERAPY AND/OR MODULATORS OF INTRATUMORAL INTERFERON

The present invention relates, in part, to methods of treating a subject afflicted with a cancer comprising administering to the subject a therapeutically effective amount of an agent that inhibits or promotes the copy number, the expression level, and/or the activity of one or more biomarkers listed in Table 1 or a fragment thereof. Also provided herein are methods of detecting ADAR1 or ISG15 dependency in a high proliferation cell (e.g., a cancer cell). Also provided are methods of detected increased interferon signaling pathway activity in a high proliferation cell (e.g., a cancer cell). Included herein are methods of treating cancer with inhibitors of ADAR1 or ISG15. Methods of screening for such inhibitors are also provided herein. Methods of identifying the likelihood of a cancer to be responsive to an ADAR1 inhibitor are also provided.

スペース効率の良いオブジェクト・ロッキング・システム及び方法

(57)【要約】 （修正有） 【課題】 必要に応じてロックデータにスペースを割り 当てる。 【解決手段】 このシステムは、グローバルなオブジェ クトロッキング手順を用いて、決してロックされないオ ブジェクト及び最近ロックされていないオブジェクトの ロック要求に応じると共に、ローカルなオブジェクト特 有のロッキング手順を用いて、ロックされたオブジェク ト及び最近ロックされたオブジェクトのロック要求に応 じる。グローバルなオブジェクトロッキング手順は、指 定の非ロックオブジェクトをロック状態に変更すると共 に、各指定のオブジェクトに対してローカルなオブジェ クトロッキング手順を形成する命令を有する。このロー カルな手順は、オブジェクトのロックデータと、記憶さ れたロックデータを更新する命令とを記憶するロックデ ータサブアレーを含む。更に、ロックデータクリーンア ップ手順がローカルなオブジェクトロッキング手順を解 除する。

C-aryl glucoside SGLT2 inhibitors

Discharge produced plasma EUV light source

End user image open area maps

Systems, devices, applications, and methods for generating an open area map are disclosed. For example, a software application is configured to run on a computing platform of an end user. The end user generates an image of a layout of a walkable area. The software application performs a method of generating an open area map based on the image. The method includes applying an array of uniformly spaced objects on the image. A routable map is generated as a function of the array. The routable map is configured to provide point-to-point routing within the layout.

Open area maps with restriction content

Open area maps and related systems and methods are disclosed. For example, one method includes receiving an image of a layout corresponding to a real-world area in which a person walks about. A restriction associated to a passageway within the image is generated. The image is used to generate a routable map for point-to-point routing. Routing through or around the restriction is based on whether or not criteria for passing the restriction is met.

Cost based open area maps

Open area maps as well as related systems and methods are disclosed. For example, an open area map includes an image of a layout corresponding to a real-world area in which pedestrians walk about. An array is associated with the image. The array includes a plurality of spaced objects. A cost value is designated to each of the spaced objects. The open area map is configured for point-to-point routing based, in part, on the designation of the cost values.

Open area maps

Systems and methods associated with an open area map are disclosed. For example, one method comprises obtaining an image of a layout. The layout represents a real-world area in which a person moves about. A grid is applied on the image. The grid includes tiles that fill in a ground area of the image. A routable map is generated as a function of the grid. The routable map is configured to provide point-to-point routing within the layout.

Open area maps based on vector graphics format images

Systems and methods corresponding to an open area map are disclosed. For example, one method includes receiving an image of a layout corresponding to a real-world area in which a person moves about. The image is in a vector graphics format. A reference region is determined using the image of the layout. A grid is combined with the reference region to generate a routable map. The routable map is configured to provide point-to-point routing within the layout.

Positioning open area maps

Open area maps as well as related features, systems, and methods are disclosed. For example, one method comprises translating coordinates associated with an open area map into real-world coordinates. The open area map is positioned within a geographic map as a function of the real-world coordinates. The geographic map represents a real-world area around the open area map. The open area map includes an image of a layout representing a pedestrian walkable area, and the open area map is configured to provide point-to-point routing within the layout.

End user image open area maps

Systems, devices, applications, and methods for generating an open area map are disclosed. For example, a software application is configured to run on a computing platform of an end user. The end user generates an image of a layout of a walkable area. The software application performs a method of generating an open area map based on the image. The method includes applying an array of uniformly spaced objects on the image. A routable map is generated as a function of the array. The routable map is configured to provide point-to-point routing within the layout.

Open area maps based on vector graphics format images

Systems and methods corresponding to an open area map are disclosed. For example, one method includes receiving an image of a layout corresponding to a real-world area in which a person moves about. The image is in a vector graphics format. A reference region is determined using the image of the layout. A grid is combined with the reference region to generate a routable map. The routable map is configured to provide point-to-point routing within the layout.

Open area maps

Systems and methods associated with an open area map are disclosed. For example, one method comprises obtaining an image of a layout. The layout represents a real-world area in which a person moves about. A grid is applied on the image. The grid includes tiles that fill in a ground area of the image. A routable map is generated as a function of the grid. The routable map is configured to provide point-to-point routing within the layout.

Open area maps

Systems and methods associated with an open area map are disclosed. For example, one method comprises obtaining an image of a layout. The layout represents a real-world area in which a person moves about. A grid is applied on the image. The grid may include tiles that fill in a ground area of the image. A routable map is generated as a function of the grid. The routable map is configured to provide point-to-point routing within the layout.

Open area maps with restriction content

Open area maps and related systems and methods are disclosed. For example, one method includes receiving an image of a layout corresponding to a real-world area in which a person walks about. A restriction associated to a passageway within the image is generated. The image is used to generate a routable map for point-to-point routing. Routing through or around the restriction is based on whether or not criteria for passing the restriction is met.

End user image open area maps

Systems, devices, applications, and methods for generating an open area map are disclosed. For example, a software application is configured to run on a computing platform of an end user. The end user generates an image of a layout of a walkable area. The software application performs a method of generating an open area map based on the image. The method includes applying an array of uniformly spaced objects on the image. A routable map is generated as a function of the array. The routable map is configured to provide point-to-point routing within the layout.

Instruments and methods employing thermal energy for the repair and replacement of cardiac valves

The present invention is methods and devices for improving valve function in a heart. Particularly a device of the present invention comprises a an elongate member having a distal end and a proximal end, a thermal heating member fixed to the distal end of the elongate member, wherein the thermal heating member includes at least one thermal heating element adapted to supply thermal energy to a heart valve structure, and an energy source in communication with the thermal heating element. In use, a thermal heating device of the present invention is inserted into working space proximate the valve to be treated and is used to selectively contract the collagen fibers of the valve structure treated so as to improve the performance and functioning of the valve. Devices are disclosed suitable for use with a variety of access procedures on both beating and non-beating hearts, including: a minimally invasive surgical procedure, a sternotomy, a thoracotomy, an endovascular procedure, and endoscopic procedure, or a percutaneous procedure. Methods and devices are disclosed which are suitable for treatment of a chordae, leaflet, or annulus, as well as devices and methods for the replacement of heart valve with prosthetic valves.

C-ARYL GLUCOSIDS AS SELECTIVE INHIBITORS OF GLUCOSE CONVEYORS (SGLT2)

Un compuesto de la formula (1), también un método para tratar la diabetes y enfermedades relacionadas empleando el compuesto de formula (1) solo o en combinacion con otro agente terapéutico. A compound of the formula (1), also a method for treating diabetes and related diseases using the compound of formula (1) alone or in combination with another therapeutic agent.

Methods and apparatus for treatment of obesity with an ultrasound device movable in two or three axes

Method and apparatus for treating obesity by an energy delivery device, such as a high focus ultrasound transducer, mounted for movement along two or three axes relative to the esophagus to deliver transesophageal energy to interrupt the function of vagal nerves. Preferably, movement along a longitudinal axis of the esophagus changes the site to which the energy is directed and movement transversely along a radius of the esophagus focuses the energy on a vagal nerve. The third degree of freedom relative to the esophagus is to rotate the transducer about the longitudinal axis of the esophagus.

Methods and apparatus for testing disruption of a vagal nerve

Method and apparatus for disrupting a gastric vagal nerve in the gastroesophageal region and testing the function and disruption of the vagal nerve. In one example embodiment, a treatment device applies ultrasound at a high energy level, such as high intensity focused ultrasound, to a vagal nerve to disrupt it and then ultrasound at a lower energy level to another portion of the vagal nerve, preferably further from the stomach, so as to stimulate the vagal nerve. Alternative ways to test the function or disruption of the vagal nerve involve using PCP-GABA, a pancreatic polypeptide, pressure changes inside the stomach, the gastric mucusol pH, a dye agent in the stomach, and other tests.

Surgical method for stabilizing the beating heart during coronary artery bypass graft surgery

The invention is methods and devices which a surgeon may use to stabilize the beating heart during a surgical procedure on the heart. Pursuant to the invention, a stabilizing device is introduced through an opening in the chest and brought into contact with the beating heart. By contacting the heart with the device and by exerting a stabilizing force on the device, the motion of the heart caused by the contraction of the heart muscles is effectively eliminated such that the heart is stabilized and the site of the surgery moves only minimally if at all. Typically, in separate steps, the surgeon contacts the heart with the stabilizing device, assesses the degree of movement of the anastomosis site, and exerts a force on the stabilizing device such that the contraction of the beating heart causes only minimal excess motion at the surgery site. By fixing the position of the stabilizing device in a configuration where the motion of the beating heart is effectively eliminated, the surgeon is able to stabilize the beating heart for the duration of the procedure. The stabilizing device may be attached to a rigid support or may be attached to a semi-rigid support which is rendered motionless mechanically, chemically, or by human intervention. In certain preferred embodiments, the stabilizing device is affixed to a semi-rigid support which is caused to become rigid, by any of a variety of techniques, such that the position of the stabilizing device becomes fixed by the support, and the heart remains substantially motionless for the duration of the procedure.

Vascular sheath with puncture site closure apparatus and methods of use

Apparatus and methods are provided for use in sealing a vascular puncture site. The invention comprises an introducer sheath with an integrated closure component. The closure component includes an advanceable resilient spring clip with an expanded delivery configuration in which opposing sides do not contact one another, and an unstressed deployed configuration, in which opposing sides close towards one another. The clip is advanced along the sheath until it pierces opposing sides of a vessel wall at a puncture site. The sheath then is withdrawn, thereby causing the clip to resiliently return to its unstressed deployed configuration and draw opposing sides of the puncture together to seal the wound.

Apparatus and methods for delivering a closure device

An apparatus for delivering a clip to close an opening through tissue includes a sheath and a carrier assembly including a clip therein that is slidable on the sheath. An actuator assembly is connectable to the sheath, and telescoping actuator members extend from the handle that are connectable to the carrier assembly for advancing the carrier assembly along the sheath. An obturator on the actuator assembly includes splines that may be deployed beyond a distal end of the sheath, and expanded to a transverse expanded configuration for positioning the sheath before deploying the clip. The actuator members include cooperating detents that selectively release the actuator members as the carrier assembly reaches predetermined positions along the sheath for deploying the clip from the carrier assembly, and that collapse the splines to allow removal of the apparatus after deploying the clip.

Compact ocular measuring system

Apparatus for determining refractive aberrations of the eye of a patient includes an instrument housing having a light source for projecting a substantially focused beam of light at the back of the eye of a patient, said substantially focused beam acting as a secondary source for a return light path of a fonned outgoing wavefront exiting said eye. An electronic sensor is disposed along said light return path, said electronic sensor having a light detecting surface disposed perpendicular to said return light path, and at least one microoptics array disposed between the electronic sensor and the eye along said return light path. The microoptics array includes plurality of lenslets disposed in a plane perpendicular to said light return path and positioned relative to said electronic sensor so as to substantially focus incremental portions of the outgoing wavefront onto the light detecting surface such that the deviations in the positions of the substantially focused portions impinging on said light detecting surface can be measured so as to determine aberrations of said wavefront. Preferably, at least one pair of conjugate lenses is disposed along said return light path and positioned between said eye and the microoptics array, the lenses of said conjugate pair having unequal focal lengths to allow the device to be used at an effective working distance from a patient

Compositions and methods for identification, assessment, prevention, and treatment of t-cell exhaustion using cd39 biomarkers and modulators

The present invention is based on the identification, of compositions and methods For the identification, assessment, prevention, and treatment of T-cell exhaustion using CD39 biomarkers and modulators.

Endoscope

Method of finishing containers impregnated with wax

Computer executable workflow control system

A computer system (16) executable method for controlling access to, or processing of, a work item (10). The work item (10) is stored in a database (14) of work items (10) for subsequent execution by at least one operator. The database (14) is used by a plurality of organizations of which the operator belongs to one. The method stores a plurality of organization identifiers (44), each one corresponding to one of the organizations, in a memory. Also stored are definitional data items (56), each one being associated with one of the organization identifiers (44). The method provides the operator with access to, or allows the operator to be affected by, one of the definitional data items (56) only if the operator is associated with the same organization identifier (44) associated with the definitional data item (56), which controls access to, or processing of, the work item (10).

Accumulator and Collator for Packaging Apparatus

Abstract of the Disclosure The accumulator for a packaging apparatus comprises conveyor type structure which is positioned between a sealing station of a packaging apparatus and a cutting station of the apparatus. The accumulator accumulates chained packages thereon during periods of downtime of a cartoner of the apparatus allowing package formation to continue for a significant period of time prior to necessitating shutdown of the entire apparatus. The accumulator is fed packages by a controller which correlates rate of package production to the speed of the accumulator to allow for up to twenty minutes of cartoner downtime prior to necessitating shutdown of the entire apparatus.

Open area maps

OPEN AREA MAPS Systems and methods associated with an open area map are disclosed. For example, one method comprises obtaining an image (201) of a layout. The layout represents a real-world area in which a person moves about. A grid (300) is applied on the image. The grid (300) includes tiles (304) that fill in a ground area of the image (201). A routable map is generated as a function of the grid (300). The routable map is configured to provide point-to-point routing within the layout.

Closure device and methods for making and using them

A clip for engaging tissue includes a generally annular-shaped body defining a plane and disposed about a central axis extending normal to the plane. The body includes alternating inner and outer curved regions, defining a zigzag pattern about a periphery of the clip. The body is biased towards a planar configuration lying in the plane and deflectable towards a transverse configuration extending out of the plane. Tines extend from the inner curved regions, the tines being oriented towards the central axis in the planar configuration, and parallel to the central axis in the transverse configuration. The tines may include primary tines and secondary tines that are shorter than the primary tines. The primary tines may be disposed on opposing inner curved regions and oriented towards one another such that they overlap in the planar configuration.

Methods to rejuvenate a deactivated hydroformylation catalyst solution

Disclosed herein are methods to rejuvenate a deactivated hydroformylation catalyst solution wherein the solution comprises rhodium, polydentate phosphine ligands, and polydentate phosphine ligand degradation products. In one embodiment, such methods comprise adding a peroxide to the deactivated hydroformylation catalyst solution.

Plasma focus light source with active and buffer gas control

A high energy photon source. A pair of plasma pinch electrodes are located in a vacuum chamber (10). The chamber (10) contains a working gas which includes a noble buffer gas and an active gas chosen to provide a desired spectral line. A pulse power source provides electrical pulses at repetition rates of 1000 Hz or greater and at voltages high enough to create electrical discharge between the electrodes to produce very high temperature, high density plasma pinches in the working gas providing radiation at the spectral line of the source or active gas. A fourth generation unit is described which produces 20 mJ, 13.5 nm pulses into 2 pi steradians at repetition rates of 2000 Hz with xenon as the active gas. This unit includes a pulse power system having a resonant charger charging a charging capacitor bank, and a magnetic compression circuit comprising a pulse transformer for generating the high voltage electrical pulses at 2000 Hz or greater. Gas flows in the vacuum chamber are controlled to assure desired concentration of active gas in the discharge region and to minimize active gas concentration in the beam path downstream of the pinch region. In a preferred embodiment, active gas is injected downstream of the pinch region through a nozzle (2) and exhausted axially through an exhaust port (3) in the center of the anode. In another preferred embodiment a laserbeam generates metal vapor at a location close to but downstream of the pinch region and the vapor is exhausted axially through the anode.

Systems and methods for buffer gas flow stabilization in a laser produced plasma light source

System managing gas flow between chambers of an extreme ultraviolet (euv) photolithography apparatus

Laser thin film poly-silicon annealing system

A gas discharge laser crystallization apparatus and method for performing a transformation of a crystal makeup or orientation in a film on a workpiece is disclosed, which may comprise a master oscillator power amplifier MOPA or power oscillator power amplifier configured XeF laser system producing a laser output light pulse beam at a high repetition rate and high power with a pulse to pulse dose control; an optical system producing an elongated thin pulsed working beam from the laser output light pulse beam. The apparatus may further comprise the laser system is configured as a POPA laser system and further comprising: relay optics operative to direct a first output laser light pulse beam from a first laser PO unit into a second laser PA unit; and, a timing and control module timing the creation of a gas discharge in the first and second laser units within plus or minus 3 ns, to produce the a second laser output light pulse beam as an amplification of the first laser output light pulse beam. The system may comprise divergence control in the oscillator laser unit. Divergence control may comprise an unstable resonator arrangement. The system may further comprise a beam pointing control mechanism intermediate the laser and the workpiece and a beam position control mechanism intermediate the laser and the workpiece. Beam parameter metrology may provide active feedback control to the beam pointing mechanism and active feedback control to the beam position control mechanism.

Surgical apparatus and treatment to keep heart stable during coronary artery bypass operation

(57)【要約】 【課題】 本発明は、外科医が心臓に対する外科的処置 の際に拍動する心臓を安定させるのに用いうる方法およ び装置を提供する。 【解決手段】 安定化装置は、胸部の開口を通して導入 されて、拍動する心臓に接触する。この装置を心臓に接 触させ、装置に安定化力を加えることによって、心筋の 収縮によって起こる心臓の動きが効果的に解消されて、 心臓が安定し、手術部位は、たとえ動いたとしても最小 限の動きしかしなくなる。一般的に、別々の段階で、外 科医は、心臓に安定化手段を接触させ、吻合部位の動き の度合いを分析し、安定化手段に力を加えて、拍動する 心臓の収縮が手術部位に最小限の動きしか引き起こさな くなるようにする。安定化手段の位置を、拍動する心臓 の動きが効果的に解消される状態で固定することによ り、外科医は、拍動する心臓を処置の継続時間にわたっ て安定させることができる。

Machine for sizing and punching vehicle wheel rims

Flameless fluid heater

Heat from a rotating prime mover(s) driving a fluid shear pump, heat from the prime mover and any exhaust heat generated by the prime mover is collected. The heat energy collected from all of these sources is transmitted through heat exchangers to a fluid where heat energy is desired. This fluid heating process is performed in the absence of an open flame.

Reading/writing information on a storage medium

A method and device for storing and accessing information on a flat storage medium (116) having X and Y axes. A read/write head (120a) is positioned adjacent to the medium and an X-axis motor (108-109) creates a reciprocating substantially linear motion between the head and the medium along the X-axis of the medium. A Y-axis motor (112) creates a linear motion between the head and the medium along the Y-axis of the medium. The head causes information to be stored or accessed on the medium as the head moves across the X-axis of the medium. The relative substantially linear motion of the head along the Y-axis moves the head from track to track along the medium. The relative motion between the head and the medium can be created by moving either the head or the medium.

Computer executable workflow resource management system

A computer system executable method is provided for managing resources in an automated workflow system for manipulating a work item. A first definitional data item affecting how the workflow system processes work items meeting a predetermined criteria is stored in a memory. A directive is received to remove the first definitional data item from the memory. A mark associated with the first definitional data item is set to indicate that the first definitional data item is to be removed from the memory. The mark is used to prevent a second definitional data item from being made dependent on the first definitional data item after the mark was set. It is determined whether any other definitional data items are dependent on the first definitional data item. Depending on the outcome of the determination, the first definitional data item is removed from the memory.

Closure system and methods of use

A closure system and methods of use are provided for use in sealing an opening in a body tissue, such as a vascular puncture site. A method of closing the opening in the body tissue can be performed with the closure system having a closure clip. The method can include positioning the closure clip in a first closure clip position adjacent to the opening in the body tissue such that a plurality of spikes of the closure clip are inserted into the tissue at a location outward from a central axis of the opening. Subsequently, the closure clip can be positioned in a second closure clip position such that the plurality of spikes are pulled inward toward the central axis of the opening so as to pull the tissue between the opening and each of the spikes together and close the opening.

Patent DE2726712C2

Closure device and methods for making and using them

A clip for engaging tissue includes a generally annular-shaped body defining a plane and disposed about a central axis extending normal to the plane. The body includes alternating inner and outer curved regions, defining a zigzag pattern about a periphery of the clip. The body is biased towards a planar configuration lying in the plane and deflectable towards a transverse configuration extending out of the plane. Tines extend from the inner curved regions, the tines being oriented towards the central axis in the planar configuration, and parallel to the central axis in the transverse configuration. The tines may include primary tines and secondary tines that are shorter than the primary tines. The primary tines may be disposed on opposing inner curved regions and oriented towards one another such that they overlap in the planar configuration.

Document display method and electronic document system

(57)【要約】 【課題】 読み取りプロセスを妨害することなく、読 者に関連ドキュメントを示す方法及びシステムを提供す る。 【解決手段】 ドキュメント読み取りシステムが、ド キュメントを受動的に分析し、ドキュメントにおける注 記事項付きの一節またはドキュメント全体に関連した、 他のドキュメントに対する欄外の注または後注を生成す る。本発明では、ドキュメントの注記事項に応答し、注 記事項付きの一節と同様の内容を備えたドキュメントの 検索を行う問合せを受動的に生成する。検索されるドキ ュメントは、注記事項付近の欄外に配置された選択可能 なリンクを介して読者が入手可能である。さらに、本発 明では、注記事項付きドキュメントの内容と全体として 同様の内容のドキュメントに対するリンクが後注で与え られる。本発明は、関連ドキュメントに対する選択可能 なリンクを受動的に生成して、ユーザが新規ドキュメン トと以前に読み取った資料を関連づけるのを助けること によって、読者を支援する。

Closure device

A clip for engaging tissue includes a generally annular-shaped body defining a plane and disposed about a central axis extending normal to the plane. The body includes alternating inner and outer curved regions, defining a zigzag pattern about a periphery of the clip. The body is biased towards a planar configuration lying in the plane and deflectable towards a transverse configuration extending out of the plane. Tines extend from the inner curved regions, the tines being oriented towards the central axis in the planar configuration, and parallel to the central axis in the transverse configuration. The tines may include primary tines and secondary tines that are shorter than the primary tines. The primary tines may be disposed on opposing inner curved regions and oriented towards one another such that they overlap in the planar configuration.

Massage chair

Systems and methods for target material delivery protection in a laser produced plasma euv light source

Magnetic compass

Abstract of the Disclosure A magnetic compass comprises: a gimbal mounted direct read card supported on a bearing in the equatorial plane of the compass in a compass bowl; and a housing having a base to which the compass bowl and corrector magnets are mounted; the corrector magnets being positioned above the base beside the bowl for access without moving the compass; means for supporting the corrector magnets located on three axes, one axis parallel to the lubber line and the equatorial plane of the compass in a horizontal orientation of the housing, a second normal to the lubber line and parallel to the equatorial plane and a third normal to the equatorial plane in a horizontal orientation of the housing and parallel to the lubber line and the equatorial plane in a vertical orientation of the housing; said corrector magnets mounted on two of said axes, said second axis and the one of said first and third axes parallel to said lubber line in the horizontal or vertical orientation selected for mounting said compass; the compass card assembly and the compass card extending below the equatorial plane at its periphery and having a mass therebelow at least as great as the mass above the plane and the housing positioned above the equatorial plane on one side below the equatorial plane on the other side for viewing the compass card at and below the equatorial plane; and light emitting diodes being provided within the housing on the one side for lighting the card and a non-magnetic battery power source being provided in the housing for powering the light emitting diodes.

Methods for identification t-cell exhaustion using cd39 biomarkers and modulators

System and method for communicating data using constant amplitude waveform with hybrid orthogonal and msk or gmsk modulation

A communications system of the present invention includes a transmitter that is operative for combining an orthogonal Walsh modulation with a minimum shift keying or Gaussian minimum shift keying waveform to form a hybrid communications signal that carries communications data over a constant amplitude waveform that is spread in time and frequency. This communications signal can be transmitted to a RAKE receiver that has a plurality of correlators with output weights formed for processing this hybrid communications signal.

Communications system using an adaptive filter and variable delay before the adaptive filter taps

A communication system receives a modulated signal that carries encoded communication data. An adaptive filter has a plurality of adaptive filter taps and weighted coefficients and a variable delay circuit operative before the adaptive filter taps for separating the spacing of multipath introduced by adaptive filter and producing a filtered output signal with improved multipath performance. A demodulator and decoder receive the filtered output signal from the adaptive filter and demodulate and decode the signal to obtain the communications data.

Communications system using adaptive filter with normalization circuit

SGLT2 INHIBITORS OF C-ARYL AND METHOD GLUCOSIDS

Un compuesto que tiene la estructura<EMI FILE="00077048_1" ID="1" IMF=JPEG >caracterizado porque: R1, R2 y R2a son independientemente hidrógeno, OH, OR5, alquilo, CF3, OCHF2, 0CF3, SR51 o halógeno, o dos de R1, R2 y R2a junto con los carbonos a los cuales están unidos, pueden formar un carbociclo o heterociclo de cinco, seis o siete elementos, deseados, los cuales pueden contener 1 a 4 heteroátomos en el anillo, los cuales son N, O, S, SO, y/o SO2. A compound having the structure <EMI FILE = "00077048_1" ID = "1" IMF = JPEG> characterized in that: R1, R2 and R2a are independently hydrogen, OH, OR5, alkyl, CF3, OCHF2, 0CF3, SR51 or halogen, or two of R1, R2 and R2a together with the carbons to which they are attached, can form a desired five, six or seven element carbocycle or heterocycle, which may contain 1 to 4 ring heteroatoms, which are N , O, S, SO, and / or SO2.

Surgical tools for stabilizing a throbbing heart in cardiovascular operations

Oppfinnelsen angår fremgangsmåter og anordninger som en kirurg kan bruke for å stabilisere et bankende hjerte under en kirurgisk operasjon på hjertet. Ifølge oppfinnelsen føres en stabiliseringsanordning gjennom en åpning i brystet og bringes i kontakt med det bankende hjerte. Ved å bringe anordningen i kontakt med hjertet og utøve en stabiliserende kraft på anordningen elimineres effektivt bevegelsen av hjertet forårsaket av sammentrekningen av hjertemuskulaturen således at hjertet blir stabilisert og operasjonsstedet beveger seg minimalt, om i det hele tatt. I adskilte trinn vil kirurgen typisk bringe stabiliseringsutstyret i kontakt med hjertet, vurdere graden av bevegelse på anastomoseområdet og utøve en kraft på stabiliseringsutstyret således at sammentrekningen av det bankende hjerte skaper minimal adgangsbevegelse på operasjonsstedet. Ved å fastsette stillingen av stabiliseringsutstyret i en utforming hvor bevegelsen av hjertet blir effektivt eliminert, er kirurgen i stand til å stabilisere det bankende hjerte under hele varigheten av operasjonen. Stabiliseringsutstyret kan bli festet til en stiv støtte eller kan bli festet til en halvstiv støtte som mekanisk, kjemisk eller ved menneskelig handling gjøres bevegelsesløs. I visse foretrukne utførelsesformer er stabiliseringsutstyret festet til en halvstiv støtte som bringes til å bli stiv ved hjelp av en hvilken som helst av mange slags teknikker, slik at stabili- seringsutstyrets posisjon blir fastlagt ved hjelp av støtten og hjertet blir hovedsakelig bevegelsesløst så lenge operasjonen varer.

Method for lpp drive laser output during euv non-output periods

Surgical instruments and procedures for stabilizing the beating heart during coronary artery bypass graft surgery

Methods and devices used to stabilize a beating heart during a surgical procedure on the heart and to expose a surgical site are disclosed. The stabilizing device is introduced through an opening through the chest and brought into contact with the beating heart, and by exerting a stabilizing force on the device, the motion of the heart caused by the contractions of the heart muscles is effectively eliminated. Exposure members are actuable to reposition a portion of the surface of the heart to better expose a target artery or other surgical site. Accordingly, the heart is stabilized and movement of the site of the surgery is minimized. Typically, in separate steps, a surgeon contacts the heart with the stabilizing device, assesses the degree of movement of the anastomosis site, and exerts a force with a stabilizing device such that the contractions of the beating heart causes only minimal excess motion at the surgery site, whereupon exposure members further reposition heart tissue to better expose the surgical site. The stabilizing device may be attached to a rigid support or may be attached to a semi-rigid support which is rendered motionless mechanically, chemically or by human intervention.

Soft-start pump control system

A soft-start pump controller system (10) for controlling a pump motor includes a switching device for supplying power to the pump motor, a periodic duty cycle generator (18) for periodically actuating the switching device at a fraction of the full duty cycle to operate the pump at a reduced, quieter level; a sensor (16) for sensing the current drawn by the pump motor (12); a reference circuit (28); and a liquid detector (24) for detecting the presence of the liquid to be pumped, responsive, to the sensor and the reference circuit, for overriding the periodic duty cycle generator and actuating the switching device to operate the pump motor continuously at full power when the motor current exceeds a predetermined level indicating liquid is present.

Method for measuring transmitted amount of vapor for material

(57)【要約】 【課題】 材料の蒸気透過量を正確に測定できる方法の 提供。 【解決手段】 まず、テストチャンバとサンプル材料に 対する蒸気透過量を測定し、そのあとサンプル材料と隣 接するテスト材料に対して測定を繰り返すことによって テスト材料の蒸気透過量を測定する。測定された第１の 透過量の逆数を測定された第２の透過量の逆数から差し 引くことによって、テスト材料の蒸気透過量の逆数であ る値を求めることができる。

Bicycle handle-bar.

Wireless communication system with selective preamble synchronization portion and related methods

A wireless communications device may include a transceiver, a memory configured to store a predetermined set of preamble synchronization portions, each preamble synchronization portion having a different length, and a controller cooperating with the transceiver and the memory. The controller may be configured to receive forward transmission blocks, each forward transmission block having a preamble synchronization portion and a body portion associated therewith. The preamble synchronization portion may include a desired preamble synchronization portion from among the predetermined set of preamble synchronization portions. The controller may be configured to determine and use, for each received forward transmission block, the corresponding preamble synchronization portion from among the predetermined set of preamble synchronization portions.

O-aryl glucoside SGLT2 inhibitors and method

Method and system for generating ad hoc from free from ink

(57)【要約】 【課題】 読者が電子文書のノード間にアドホックなリ ンクを張れるようにする。 【解決手段】 フリーフォームインクに応じて節と節と の間にリンクを生成し、フリーフォームインクによるア ノテーションやノート作成の機能を強化する。リーディ ング／ライティングシステム１０はフリーフォームイン クアンカー６２の間にリンクを生成し、フリーフォーム インクストロークがウィンドウの境界を越えて伸びる場 合、異なるウィンドウにある文書間にリンクを生成す る。リンクを表すフリーフォームインクストロークが消 去されると、そのリンクを除去する。また、対応するリ ンクが選択されると、ディスプレイにインクアンカーを 表示し、リンクされた関連する全てのアンカーを周囲の コンテクストとともに示す。

Metrology for extreme ultraviolet light source

Catecholamine substitutes suitable as beta 3 agonists

Compounds of the formula <CHEM> or pharmaceutically acceptable salts thereof wherein: A is a bond, -(CH2)n- or -CH(B)-, where n is an integer of 1 to 3 and B is -CN, -CON(R<9>)R<9'> or -CO2R<7>; R<1> is lower alkyl, aryl or arylalkyl; R<2> is hydrogen, hydroxy, alkoxy, -CH2OH, cyano, -C(O)OR<7> , -CO2H, -CONH2, tetrazole, -CH2NH2 or halogen; R<3> is hydrogen, alkyl, heterocycle or <CHEM> R<4> is hydrogen, alkyl or B; R<5>, R<5'>, R<8>, R<8'> or R<8''> are independently hydrogen, alkoxy, lower alkyl, halogen, -OH, -CN, -(CH2)nNR<6>COR<7>, -CON(R<6>)R<6'>, -CON(R<6>)OR<6'>, -CO2R<6>, -SR<7>, -SOR<7>, -SO2R<7>, -N(R<6>)SO2R<1>, -N(R<6>)R<6'>, -NR<6>COR<7>, -OCH2CON(R<6>)R<6'> , -OCH2CO2R<7> or aryl; or R<5> and R<5'> or R<8> and R<8'> may together with the carbon atoms to which they are attached form an aryl or heterocycle; R<6> and R<6'> are independently hydrogen or lower alkyl; and R<7> is lower alkyl; R<9> is hydrogen, lower alkyl, alkyl, cycloalkyl, arylalkyl, aryl, heteroaryl; or R<9> and R<9'> may together with the nitrogen atom to which they are attached form a hetocycle; with the proviso that when A is a bond or -(CH2)n and R<3> is hydrogen or unsubstituted alkyl, then R<4> is B or substituted alkyl. These compounds are beta3 adrenergic receptor agonists and are useful, therefore for example, in the treatment of diabetes, obesity and gastrointestinal diseases.

Communications system using adaptive filter that is selected based on output power

A communications system receives a modulated signal that carries encoded communications data. An adaptive filter has an input, a plurality of non-adaptive and adaptive filter taps with weighted coefficients, and an output. The received signal is passed through the adaptive filter and around adaptive filter and a switch selects which signal to pass to demodulator based on measured output power of the adaptive filter and of the original received signal. A demodulator and decoder receive the filtered output signal and demodulate and decode the signal to obtain the communications data.

Multi-channel communication method, multi-channel electric communication system, general computing device, electric communication infrastructure, and multi- channel communication program

(57)【要約】 （修正有） 【課題】 複数の電話による会話を同時に実行するため のシステムおよび方法を提供する。 【解決手段】 一実施形態では、ユーザは第１チャネル で一個人と会話しながら、同時に第２の個人または第２ チャネルに可聴発話を送信する。ユーザは所望のチャネ ル（単数または複数）および所望の句を選択することが でき、選択された句の電子表現が選択されたチャネルを 介して伝送される。

High pulse rate pulse power system

Reliable, modular, production quality narrow-band krf excimer laser

Closure system and methods of use

An apparatus for sealing a passage through tissue communicating with a body lumen is provided. The apparatus includes an elongate member having a proximal end a distal end and a lumen extending from the distal end toward the proximal end defining a longitudinal axis. A plug member is disposed on the distal end and extends distally from the elongate member in a pre-deployed and deployed configuration. The plug member includes a distal port therein in communication with the lumen and has a cross-sectional diameter at a plug proximal end and a plug distal end greater than a cross-sectional diameter of the distal end of the elongate member in the pre-deployed configuration. The apparatus also includes a member extendable distally from the distal port, the member including a proximal end and a distal end.

System for writing in digital notebook

(57)【要約】 【課題】 ユーザーが個人用のノートの記録、参照、再 利用する方法を改良するよう設計された電子ノートブッ クを提供する。 【解決手段】 ディジタルノート記入システムは、ペン ベースの入力を受け取るのに使用されるペンベースの対 話形ディスプレイ装置２４を含み、ペンベースの対話形 ディスプレイ装置２４との通信を行なうと共にペンベー スの入力に応答してペンベースの対話形ディスプレイ装 置２４に表示するために少なくとも一つのノートマーク を発生するプロセッサ１８を含み、ディジタルインクは 少なくとも一つの特性を有し、ディジタルインクを記憶 するためにプロセッサ１８と通信を行なう記憶装置２０ を含む。

Grain and crop drying method, system, and apparatus

A grain dying system for a grain bin that includes a heating unit arranged in a proximity of the grain bin and ducting connected at one end to the heating unit and another end to a grain drying adaptor. The grain drying adaptor is connected at one end to the ducting and at another end to a fain unit of an aeration system for the grain bin. The fan unit is attached to the grain drying adaptor. The grain drying adaptor is configured to introduce a blend of heated air from the heating unit and ambient air from outside the grain drying adaptor into the aeration system of the grain bin.

System and method for integrating paper-based business documents with computer-readable data entered via a computer network

A method of integrating paper-based business documents (20) requiring an original signature with electronic data about the documents and for later retrieving the data entered to create the documents is characterized by the steps of having an end user (18) or an agent enter all required data for creating the required document, saving the gathered data in a database (28), associating the saved data with a unique identification code (32), and printing the unique identification code (32) on the paper-based document when it is printed (26). The printed paper-based document is signed by the end user and submitted with supporting documentation. When the document is received by the business client (14), the business client (14) inputs the identification code (32) which is used to access the stored data and populate the business client's (14) own database (30) with all of the data used to create the original documents.

System and method for controlling a work implement of a machine

A control system for a work implement of a machine having a frame is provided. The control system includes a fluid source configured to provide a supply of pressurized fluid and a pair of tilt cylinders in fluid communication with the fluid source. The tilt cylinders are configured to operatively tilt the work implement with respect to the frame of the machine. Each of the tilt cylinders has a rod end and a cap end between which a regenerative valve is disposed to selectively allow fluid communication between the rod end and the cap end of a corresponding tilt cylinder. The control system further includes a controller communicably coupled to each of the regenerative valves. The controller is configured to vary an amount of restriction in each regenerative valve to regulate an amount of fluid flowing between the rod end and the cap end of the corresponding tilt cylinder.

O-aryl glucoside SGLT2 inhibitors and method

Formula (I) wherein Y is formula (a) or heteroaryl; A is -O(CH2)m, S, -NH(CH2)m, or (CH2)n where n is 0-3 and m is 0-2; and R1 to R6 are as defined herein. A method is also provided for treating diabetes and related diseases employing an SGLT2 inhibiting amount of the above compound alone or in combination with one, two or more other antidiabetic agents, and/or one, two or more hypolipidemic agents.

Submersible pump motor having an oil free bearing arrangement

An improved pump motor including a shaft (12) supported on either end thereof with respect to a pump housing, an impeller (32) on the terminal end of the shaft, a commutator (22a, 22b, 22c) and armature windings fixed to the shaft, and at least one oil free bearing (40) supporting the shaft with respect to the pump housing to prevent packing of the commutator and to extend the life and improve the reliability of the pump.

Building directory aided navigation

A navigation system utilizes building directories to aid navigation. A mobile device, such as a mobile phone, captures an image of a building directory. The building directory includes information regarding the names and/or locations of tenants. An image recognition algorithm is performed on the captured image to extract information from the building directory. The extracted information is used to access a map database. The mobile device may display directions or a map to guide the user to a selected destination. In addition, the captured image may be used to build the map database or update the map database. Finally, the captured image may be matched with stored images of the building directory to determine the current location of the mobile device.

Communications system and device using simultaneous wideband and in-band narrowband operation and related method

A communications device includes a signal input for receiving both wideband and in-band, narrowband communication signals having wideband communications data that is transmitted over a wideband communications channel and narrowband communications data that is transmitted within an in-band, narrowband channels over the same wideband communications channel. A circuit splits the communications signals into a wideband signal channel and narrowband signal channels. A narrowband filter within the wideband signal channel filters the wideband communications signal and removes any narrowband communications signals. A demodulator within the wideband signal channel demodulates the filtered wideband communications signal to obtain any wideband communications data. An in-band, narrowband demodulators are positioned within the narrowband signal channels and demodulate the narrowband communications signals to obtain any narrowband communications data.

HUMIDIFIED, SENSITIVE OXYGEN DETECTOR

Self-contained flameless heat transfer fluid heating system

A heating system for heating at least one of a fluid-filled conduit arrangement and a volume of air includes an internal combustion engine provided with engine coolant that flows to and from the engine and is heated thereby. A fluid heat exchanger is provided in fluid communication with a heat transfer fluid stored in a reservoir and the engine coolant of the internal combustion engine. The fluid heat exchanger receives heated engine coolant from the internal combustion engine, and transfers heat from the heated engine coolant to the heat transfer fluid to provide heated transfer fluid. A heat generator is provided in fluid communication with the fluid heat exchanger, and receives the heated transfer fluid from the fluid heat exchanger for further heating. This heated transfer fluid may then be selectively used to heat a conduit or a volume of air.

F2 dual-chamber laser system with line selection

Wheel cover

C-aryl glucoside SGLT2 inhibitors

Det beskrives SGLT2-inhibitorforbindelser med formelen hvor R1, R2 og R2a uavhengig er hydrogen, OH, OR5, lavere alkyl, CF3, OCHF2, OCF3, SR5' eller halogen, eller to av R1, R2 og R2a sammen med karbonatomene som de er tilknyttet, kan danne en annelert fem-, seks- eller syv-leddet karbocyklisk eller heterocyklisk ring; R3 og R4 er uavhengig hydrogen, OH, OR5a, OAryl, OCH2Aryl, lavere alkyl, cykloalkyl, CF3, -OCHF2, -OCF3l halogen, -CN, -CO2R5b, -CO2H, -COR6b, -CH(OH)R6c, -CH^R^R*1, -CONR6R6a, -NHCOR5c, -NHSOgR501, -NHSO2Aryl, Aryl, -SR5e, -SOR5f, -SO2R5g, -SO2Aryl, eller en fem-, seks- eller syv-leddet heterocyklisk ring, eller hvor R3 og R4 sammen med karbonatomene som de er tilknyttet danner en annelert fem-, seks- eller syv-leddet karbocyklisk eller heterocyklisk ring; R5, R53, R5b, R5c, R5d, R5e, R5f, R59, R5h og R5i er uavhengig lavere alkyl; R6, R63, R6b, R6c og R6d er uavhengig hydrogen, alkyl, aryl, alkylaryl eller cykloalkyl, eller R6 og R6a sammen med nitrogenatomet som de er tilknyttet, danner en annelert fem-, seks- eller syv-leddet heterocyklisk ring; A er O, S, NH eller (CH2)n, hvor n er 0-3. Det tilveiebringes også en fremgangsmåte for behandling av diabetes og beslektede sykdommer ved å anvende en SGLT2-inhiberende mengde av ovennevnte forbindelse, alene eller i kombinasjon med et annet antidiabetisk middel eller annet terapeutisk middel.

A high repetition rate laser produced plasma EUV light source

Method of making plastic tubes

NON BASIC S ANTAGONISTS OF THE RECEIVER OF THE CONCENTRATING HORMONE OF MELANINA 1

Compuestos que incluyen todos los estereoisomeros, solvatos, profármacos y formas farmacéuticamente aceptables de los mismos de acuerdo con la formula (1). Además composiciones farmacéuticas que contienen al menos un compuesto de acuerdo con la formula (1) y opcionalmente al menos un agente terapéutico adicional y uso de dichos compuestos para preparar medicamentos utiles para tratar una enfermedad o trastorno modulado por MCHR-1 tal como, por ejemplo, obesidad, diabetes, depresion o ansiedad. Reivindicacion 1: Un compuesto de formula 1 o una sal farmacéuticamente aceptable del mismo caracterizado porque el anillo A es un anillo fenileno o un anillo heteroarilo que contiene uno o dos átomos de nitrogeno o un átomo de oxígeno; R1 es Z-Y-X-, donde X es O, S, >S(=O)-, o >S(=O)(=O); Y es un enlace, un cicloalquilo de 3 a 6 miembros o una cadena alquilo; y Z es arilo o heteroarilo; R2 es -E-G-(J)m, donde m es un numero entero de 1 a 3; E es O, S o un enlace; G es alquilo inferior, fenilalquilo, cicloalquilo, cicloalquilalquilo, alquilcicloalquilo, cicloalcoxi, alquilcicloalcoxi o cicloalcoxialquilo, y cada J es independientemente hidrogeno, hidroxilo, CN, -SO2R7, -SR7, -SOR7, alquilo inferior, alcoxi inferior, CF3, CF3O-, -COOR5 o CO-NR5aR6, donde cada uno de R5a y R6 se selecciona independientemente entre el grupo constituido por H, alquilo C1-3 y cicloalquilo, o R5a y R6 tomados juntos pueden ser propanodiilo, butanodiilo o pentanodiilo con el átomo de N al que están unidos para formar una amina cíclica de 4, 5 o 6 miembros que puede estar opcionalmente sustituida; R5 es H, alquilo C1-6 o cicloalquilo; R7 es alquilo inferior; y R3 es alquilo C1-6, cicloalquilo, alcoxi C1-6, halogeno, hidrogeno, -S-alquilo C1-6, CN, CF3O o CF3 y donde R2 y R3 pueden tomarse juntos para formar un anillo de 5 a 7 miembros que está saturado o parcialmente insaturado y puede incluir opcionalmente un heteroátomo E que es O o 0, 1 o 2 átomos de N, donde el anillo está sustituido con uno ...