Process for producing racemicaly or optically active 4-substituted 1,3,4,5-tetrahydro-2h-1,4-benzodiazepin-2-one

1505543 Benzodiazepines RICHTER GEDEON VEGYOSZETI GYAR RT 23 May 1975 [29 May 1974] 22696/75 Heading C2C Racemic and optically active compounds of the general formula (R 1 = H, halogen, CF 3 , NH 2 , NO 2 ; R 2 = H, alkyl; R 3 = acyl group derived from carbonic acid or a derivative thereof or an optionally substituted aliphatic, alicyclic or aromatic carboxylic acid; R 6 = phenyl, halophenyl; provided that if the compound is racemic, R 2 is C 1-6 alkyl and (a) R 1 is H or halogen, R 3 is not a carbamoyl group having a C 1-6 alkyl, C 2-6 alkenyl, cyclohexyl, phenyl or benzyl substituent, or (b) R 1 is halogen or CF 3 , R 3 is not C 2-7 alkanoyl) are prepared by acylation, optionally followed by introduction of an amino or substituted amino group and/or alkylation. An amino substituent in the acylating agent may be protected during the reaction. The above compounds are tranquillo-sedatives, and may be administered in the form of pharmaceutical preparations containing them in association with a carrier.

The method of obtaining diaminobenzophenone

Method for producing derivatives of 4-substituted-1,3,4,5-tetrahydro-2h-1,4-benzodiazepin-2-on

1505543 Benzodiazepines RICHTER GEDEON VEGYOSZETI GYAR RT 23 May 1975 [29 May 1974] 22696/75 Heading C2C Racemic and optically active compounds of the general formula (R 1 = H, halogen, CF 3 , NH 2 , NO 2 ; R 2 = H, alkyl; R 3 = acyl group derived from carbonic acid or a derivative thereof or an optionally substituted aliphatic, alicyclic or aromatic carboxylic acid; R 6 = phenyl, halophenyl; provided that if the compound is racemic, R 2 is C 1-6 alkyl and (a) R 1 is H or halogen, R 3 is not a carbamoyl group having a C 1-6 alkyl, C 2-6 alkenyl, cyclohexyl, phenyl or benzyl substituent, or (b) R 1 is halogen or CF 3 , R 3 is not C 2-7 alkanoyl) are prepared by acylation, optionally followed by introduction of an amino or substituted amino group and/or alkylation. An amino substituent in the acylating agent may be protected during the reaction. The above compounds are tranquillo-sedatives, and may be administered in the form of pharmaceutical preparations containing them in association with a carrier.

Method of obtaining a-substituted benzhydrol derivatives or salts thereof

Method of preparing racemic or optically active 1,4-benzo-diazepin-2-one derivatives

1505543 Benzodiazepines RICHTER GEDEON VEGYOSZETI GYAR RT 23 May 1975 [29 May 1974] 22696/75 Heading C2C Racemic and optically active compounds of the general formula (R 1 = H, halogen, CF 3 , NH 2 , NO 2 ; R 2 = H, alkyl; R 3 = acyl group derived from carbonic acid or a derivative thereof or an optionally substituted aliphatic, alicyclic or aromatic carboxylic acid; R 6 = phenyl, halophenyl; provided that if the compound is racemic, R 2 is C 1-6 alkyl and (a) R 1 is H or halogen, R 3 is not a carbamoyl group having a C 1-6 alkyl, C 2-6 alkenyl, cyclohexyl, phenyl or benzyl substituent, or (b) R 1 is halogen or CF 3 , R 3 is not C 2-7 alkanoyl) are prepared by acylation, optionally followed by introduction of an amino or substituted amino group and/or alkylation. An amino substituent in the acylating agent may be protected during the reaction. The above compounds are tranquillo-sedatives, and may be administered in the form of pharmaceutical preparations containing them in association with a carrier.

Method for producing thioacetyl or mercapto-derived steroid lactones

Method of producing substituted derivatives of 3-nitrobenzophenone

Process for preparing derivatives of benzodiazepine

1509445 Benzodiazepines RICHTER GEDEON VEGYESZETI GYAR RT 25 June 1975 [25 June 1974] 26920/75 Heading C2C Compounds of the general formula (R 1 =halogen, CF 3 , NO 2 , NH 2 ; R 2 =H, alkyl; R 3 =NO, NH 2 , optionally substituted alkylideneamino, aralkylideneamino or acylamino) are prepared by nitrosating the 4-unsubstituted compound, optionally followed by (a) reduction and (if required) reaction with an aldehyde or acylating agent, and/or (b) alkylation. Any amino substituent(s) in the aldehyde or acylating agent may be protected during the reaction. The above compounds possess enzymeinducing properties, and may be administered in the form of pharmaceutical preparations containing them in association with a carrier.

Process for preparing 2beta,16beta-diaminoandrostane derivatives or their salts

Curare-type salts of the formula <IMAGE> (1a) or <IMAGE> (1b) WHEREIN Ac is an alkyl carbonyl group containing 1 to 4 carbon atoms in the alkyl moiety and one of R1 and R2, is a methylene group and the other is a group of the formula >N-R2 wherein R2 is an alkyl group containing 1 to 3 carbon atoms, A is halogen and R3 is an alkyl group containing 1 to 4 carbon atoms, or an alkyl group; and A PROCESS FOR THE PREPARATION THEREOF ARE DISCLOSED.

Method of preparing derivatives of bispiperazineandrostane

Process for producing triaminoandrostane derivatives, their salts or quaternary ammonium salts

New triamino-androstanes with curare-type properties and a process for the preparation thereof are disclosed.