Настройки

Укажите год
-

Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

Подробнее
-

Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

Подробнее

Форма поиска

Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
Ведите корректный номера.
Ведите корректный номера.
Ведите корректный номера.
Ведите корректный номера.
Укажите год
Укажите год
Применить Всего найдено 5523. Отображено 100.
01-03-2012 дата публикации

Downhole sample analysis method

Номер: US20120053838A1
Автор: A. Ballard Andrews, Oleg Zhdaneev, Oliver C. Mullins
Принадлежит: Schlumberger Technology Corp

A method for downhole fluid analysis is disclosed. The method includes positioning a downhole fluid sampling tool at first and second locations; extracting and compositionally analyzing samples of reservoir fluid while positioned at the first and second locations; comparing analysis results; and repositioning the tool to a third location depending on the results of the comparison. The compositional analysis can be performed using downhole gas chromatography and mass spectrometry systems and preferably can identify subtle non-homogeneities such as biomarkers. The fluid extraction can be performed using a focuses dual-flowline type sampling probe.

Подробнее
Номер записи: 1
14-06-2012 дата публикации

Field flow fractionator with controllable cross flow along its length

Номер: US20120148460A1
Автор: Philip J. Wyatt
Принадлежит: Wyatt Technology LLC

A field flow fractionator to separate particles contained within an injected sample aliquot is described. As required, said fractionator may be used to capture, for subsequent removal, specific predefined classes of such particles. Based upon the cross flow or asymmetric flow field flow fractionators, the fractionator disclosed contains means to vary the applied transverse flows at a plurality of locations along the length of its separating channel. One embodiment utilizes a plurality of separated compartments, each lying below a distinct and corresponding membrane supporting permeable frit segment, are provided individual means to control the localized flow through the membrane section thereabove. A corresponding concentric compartment implementation achieves the same type of compartmentalized cross flow when integrated with a hollow fiber fractionator.

Подробнее
Номер записи: 2
06-09-2012 дата публикации

Hydrogen storage material analyzer and analysis and activation methods

Номер: US20120225009A1
Автор: Chia-Chieh Shen, Hsueh-Chih Li, PERNG Tsong-Pyng
Принадлежит: YUAN ZE UNIVERSITY

A hydrogen storage material analyzer along with its analysis and activation methods, the hydrogen storage material analyzer including a H 2 absorption-desorption cycling tester, a temperature-programmed desorption spectrometer, a specimen holder and a temperature-controlled furnace. With this hydrogen storage material analyzer, a complete set of instruments can be used to implement simultaneously cyclic hydrogenation-dehydrogenation test and thermodynamic desorption analyses, thus improving the working efficiency and analysis accuracy.

Подробнее
Номер записи: 3
13-09-2012 дата публикации

Chromatography Apparatus Having An Integrated Core

Номер: US20120227470A1
Автор: Anthony C. Jeannotte, Geoff C. Gerhardt, Lynda Neue, Theodore A. Dourdeville, Uwe Dieter Neue
Принадлежит: Waters Technologies Corp

A chromatography apparatus includes a sample-delivery patterned substrate and a tube-based separation column directly connected to an outlet port of the patterned substrate. The patterned substrate includes an injector valve connected to the outlet port.

Подробнее
Номер записи: 4
01-11-2012 дата публикации

Method for qualifying a non-particulate ion-exchanger adsorber

Номер: US20120276652A1
Автор: Axel Thiefes, Hans-Heinrich Hoerl, René FABER, Wolfgang Demmer
Принадлежит: SARTORIUS STEDIM BIOTECH GMBH

The present invention relates to a method for the validation of a non-particulate ion exchange adsorber and a kit for the validation of a non-particulate ion exchange adsorber.

Подробнее
Номер записи: 5
08-11-2012 дата публикации

Vaporisation injector

Номер: US20120280061A1
Автор: Eric Phillips, Paolo Magni, Stefano Pelagatti
Принадлежит: Thermo Fisher Scientific SpA

The invention relates to a vaporization injector for a gas chromatograph, said injector comprising a structure ( 11 ) mounted in a detachable manner on the gas chromatograph body and including the sample introduction means, the vaporization chamber and pneumatic connections for feeding the carrier gas to the vaporization chamber and to the septum purge means, as well as pneumatic connections for evacuating the splitted sample and carrier gases.

Подробнее
Номер записи: 6
21-03-2013 дата публикации

Sample detection method by thin-layer chromatography, thin-layer chromatography plate, and method for producing same

Номер: US20130067996A1
Автор: Ichiro Okamoto, Isamu Ikeda, Noriaki Takeya, Satoru Nose, Toshiharu Minoda
Принадлежит: Daicel Corp

The present invention provides a thin-layer chromatography plate and a thin-layer chromatography that can detect the separation of a component in a sample by a separating agent layer that does not permit the detection of the separation of the component in the sample by an optical response. For a sample that has an optical response to ultraviolet light or a coloring agent, the present invention uses a thin-layer chromatography plate that has a first separating agent layer, which has the same optical response as the sample, and a second separating agent layer, which is disposed adjacent thereto and has an optical response that is different from the aforementioned optical response; carries out development of the sample in the first separating agent layer; thereafter carries out further development of the spots from the first separating agent layer toward the second separating agent layer; and detects the spots in the second separating agent layer through exposure to ultraviolet radiation or a color-development treatment with a coloring agent. In addition, the development axis in the first separating agent layer is maintained approximately perpendicular, and spot broadening at the boundary surface is prevented by adjusting the binder blending ratio.

Подробнее
Номер записи: 7
16-05-2013 дата публикации

Helium Conservation Device for a Gas Chromatograph

Номер: US20130118231A1
Автор: Edward B. Mccauley, Paolo Magni
Принадлежит: Thermo Finnigan LLC

A device for conserving helium gas in a gas chromatograph system is characterized in that during the majority of an analytical separation, helium is used as the carrier gas while an auxiliary non-helium gas is used to pressurize the inlet and provide for septum purge and split vent flow. Prior an injection period, a coaxial helium flow is established at the column entrance wherein the coaxial helium flow is less than the column flow. Following the injection and sample transfer period, a coaxial helium flow is established wherein the flow is greater than the column flow.

Подробнее
Номер записи: 8
09-01-2014 дата публикации

Automated systems and methods for detection of chemical compounds

Номер: US20140007710A1
Автор: Paul Danilchik
Принадлежит: Brooks Rand Inc

In accordance with one embodiment of the present disclosure, a method for processing a liquid test sample includes using a needle assembly to introduce a first flow of gas through an inlet in the needle assembly into a container containing a liquid test sample and to provide an outlet from the container through the needle assembly, separating at least one volatile component from the sample in a gas and liquid separator using the first flow of gas, adsorbing the at least one volatile component onto a trapping material to provide at least one adsorbed component, and releasing the at least one adsorbed component from the trapping material to provide at least one released component.

Подробнее
Номер записи: 9
30-01-2014 дата публикации

Optically heated analyte desorber for gas chromatography analysis

Номер: US20140026638A1
Автор: II Michael J. Bowers, Tadd C. Kippeny
Принадлежит: BAE Systems Information and Electronic Systems Integration Inc

Analytes are rapidly desorbed from a carbonaceous sorbent powder with improved quantitation and reduced analyte re-adsorption, thermal degradation, and rearrangement. The sample is distributed in a thin layer onto a desorption surface within a chamber. The layer can be a monolayer. Heating light irradiates the sample through a window, directly and rapidly heating the sample while the desorbed analytes diffuse into a vacuum or are removed by a carrier gas. Finally, the sorbent is flushed from the chamber by a transport gas. The desorption surface can be an inner surface of the window, or a surface of a porous frit that divides the chamber into two sections. The frit can be stainless steel or glass. The carrier gas can be helium, argon, or carbon dioxide. The light source can be a tungsten halogen lamp. A heater can control the chamber temperature according to a heating profile.

Подробнее
Номер записи: 10
03-01-2019 дата публикации

METHODS OF PRODUCING AND CHARACTERIZING VIRUS VACCINE AND VIRUS VACCINE COMPOSITION

Номер: US20190002839A1
Автор: AI Wen, LIU Dianlian, SHEN Mingfeng
Принадлежит:

This application pertains to methods of isolating virus particles and producing virus vaccine composition comprising subject a biological sample to an anion exchange chromatography and a hydroxyapatite chromatography. The application also pertains to rabies virus vaccine compositions and methods of assessing suitability of a virus vaccine composition or releasing a commercial batch of virus vaccine composition for clinical use. 1. A method of purifying rabies virus from a biological sample , comprising subjecting the biological sample to an anion exchange (“AE”) chromatography followed by a hydroxyapatite (“HA”) chromatography.2. The method of claim 1 , wherein the AE chromatography comprises:a) an AE loading step, comprising loading the biological sample to an AE column; andb) an AE elution step, comprising eluting the AE column with an AE elution buffer.3. The method of claim 1 , wherein the HA chromatography comprises:a) an HA loading step, comprising loading a post-AE chromatography sample to an HA column; ande) an HA elution step, comprising eluting the HA column with an HA elution buffer.4. The method of claim 1 , wherein the anion exchange chromatography is Capto-DEAE chromatography.5. The method of claim 1 , wherein the hydroxyapatite chromatography is CHT chromatography.6. The method of claim 2 , wherein the AE chromatography further comprises a second AE elution step comprising eluting the AE column with a second AE elution buffer claim 2 , wherein a first AE eluate and a second AE eluate are collected from the first AE elution step and the second AE elution step claim 2 , respectively claim 2 , and wherein the first AE eluate and the second AE eluate comprise virus with different structure claim 2 , purity or virus protein composition.7. The method of claim 2 , wherein the AE chromatography further comprises:a) an AE pre-equilibration step comprising pre-equilibrating the anion exchange column with an AE pre-equilibrating buffer;b) an AE equilibrating ...

Подробнее
Номер записи: 11
02-01-2020 дата публикации

PORTABLE GAS ANALYSIS DEVICE WITH COMPACT MEASUREMENT DEVICE

Номер: US20200003738A1
Автор: Jünemann Arne, SCHMITTMANN Matthias, Weber Johannes, Weber Paul
Принадлежит: bentekk GmbH

A portable gas analysis device having a separating column and a detector. The separating column is composed as a multi-capillary unit from parallel individual capillaries and, depending on the length, is bent into a compact shape, preferably even wound into multiple turns. A thermally conductive casing and a thermal stabilizing device are provided for the multi-capillary unit. The thermal stabilizing device comprises a temperature sensor, a heating element and control electronics. The casing protects the sensitive multi-capillary unit from mechanical actions; it acts as a protective space. The temperature-controlled casing also forms a space in which uniform and controlled conditions prevail and which in particular is isolated from the temperature and humidity of the environment, allowing reliable measurements outside a laboratory environment, in the field. This double effect of the casing for the capillaries in conjunction with the compact dimensions forms the true essence of the invention. 1. A portable gas analysis device comprising a measuring unit that comprises:a detector;a separation column embodied as a multi-capillary unit that comprises capillaries arranged in parallel in bent form;a casing for the multi-capillary unit, the casing comprising a material having good thermal conductivity; anda thermal stabilization unit that comprises a temperature sensor and a heating element located on the casing.2. The portable gas analysis device of claim 1 , wherein the multi-capillary unit comprises capillaries wound in multiple turns.3. The portable gas analysis device of claim 1 , wherein multiple heating elements are arranged on the casing such that the multi-capillary unit is temperature-controlled homogeneously.4. The portable gas analysis device of claim 1 , wherein the multi-capillary unit is anchored using a heat-conductive holder in the casing.5. The portable gas analysis device of claim 1 , wherein the casing encloses the multi-capillary unit in a ring shape ...

Подробнее
Номер записи: 12
07-01-2021 дата публикации

An improved thermal modulator

Номер: US20210003539A1
Автор: Carson William W., Crotti Alberto, Saini Massimiliano, Taschini Roberto
Принадлежит:

A thermal modulator for gas chromatography includes an analytical capillary to be traversed by analytes and that is interposed between two gas chromatographic columns; a cooling system having a cold zone, a support element associated with the cold zone and supporting a portion of the analytical capillary at a corresponding or slightly higher temperature than the cold zone, so as to define a trapping portion of the analytes; a control system, which selectively controls the emission of pulsed current to electrically conductive elements associated with the analytical capillary to heat the trapping portion and cause the release or desorption of previously immobilized analytes; and a heating system of a portion of the analytical capillary, positioned outside of the support element and upstream of the support element, so as to generate a rapid expansion of the gas contained in the portion and facilitate the advancement of the released or desorbed analytes. 146.-. (canceled)47. A thermal modulator for gas chromatography comprising:an analytical capillary for crossing analytes and adapted to be interposed between two gas chromatographic columns;a cooling system comprising a cold zone;a support element associated with the cold zone and configured to support a first portion of the analytical capillary so that the first portion is at a same or than the cold zone, the first portion passing through or is in contact with the support element defining a trapping portion in which the analytes passing through the analytical capillary are to be trapped or immobilized;a control system that selectively controls a sending of pulsed current to electrically conductive elements associated with the analytical capillary, so as to heat the trapping portion and cause a release or desorption of previously immobilized analytes; anda heating system that causes a heating of a second portion of the analytical capillary positioned outside of the support element and upstream of the first portion of ...

Подробнее
Номер записи: 13
07-01-2021 дата публикации

Continuous Backpressure Monitoring to Determine the System Health State of HPLC Systems

Номер: US20210003540A1
Автор: Rendl Martin
Принадлежит:

A method for determining a state of a fluidic system can include measuring back pressures in the fluidic system at different times and determining a state of the fluidic system. The determination is based on at least the measured back pressures and on additional status information indicative of at least one status of the fluidic system at at least one of the different times. 1. A method for determining a state of a fluidic system , the method comprising:measuring back pressures in the fluidic system at different times; anddetermining the state of the fluidic system, wherein the determining the state is based on at least the measured back pressures.2. The method according to claim 1 , wherein the determining the state is also based on an additional status information at at least one of the different times claim 1 , andwherein the determining the state of the fluidic system comprises: comparing the measured back pressures to at least one reference.3. The method according to claim 2 , wherein the at least one reference is based on the back pressures measured under conditions which are at least comparable to conditions at the different times.4. The method according to claim 2 , wherein the reference used in the comparing the measured back pressure depends on the additional status information.5. The method according to claim 1 , wherein the determining the state of the fluidic system further comprises:determining a deviation when an absolute value between one of the measured back pressure and at least one reference exceeds a threshold.6. The method according to claim 5 , wherein the fluidic system comprises a pump configured to generate a liquid flow claim 5 ,wherein the fluidic system is configured to include different configurations,wherein the configurations differ at least as regards which components are fluidly connected to the pump; 'the fluidic system assuming a second configuration, which is different from the first configuration, and determining whether the ...

Подробнее
Номер записи: 14
14-01-2021 дата публикации

ANALYZER

Номер: US20210010982A1
Автор: Takahashi Kazunori
Принадлежит:

An analyzer capable of suppressing the generation of noise in a current detection circuit is provided. On a board , a current detection circuit for processing an output signal from a detector is mounted. The cover member has a space in which the current detection circuit is accommodated. A gas is supplied from a gas source into the space . The cover member is provided with an inlet port for introducing the gas from the gas source into the space and an outlet port for discharging the gas in the space 1. An analyzer comprising:a detector configured to detect components in a sample;a board on which a current detection circuit for processing an output signal from the detector is mounted;a cover member having a space in which a current detection circuit is accommodated; anda gas source configured to supply a gas to the space,wherein the cover member is provided with an inlet port for introducing the gas from the gas source into the space and an outlet port for allowing the gas in the space to flow out.2. The analyzer as recited in claim 1 , further comprising:a column to which a sample is supplied together with a carrier fluid,wherein the gas source is configured to supply the gas as the carrier fluid to the column.3. The analyzer as recited in claim 1 ,wherein the gas source is configured to supply the gas to the detector,4. The analyzer as recited in claim 1 , further comprising:a base member configured to hold the board,wherein the cover member is attached to the base member to cover the board and the current detection circuit mounted on the board.5. The analyzer as recited in claim 1 ,wherein the cover member is attached to the board to cover the current detection circuit.6. The analyzer as recited in claim 1 , further comprising:a Peltier element provided in the space to cool an electronic component included in the current detection circuit.7. The analyzer as recited in claim 1 ,wherein the gas is an inert gas.8. The analyzer as recited in claim 1 , further ...

Подробнее
Номер записи: 15
10-01-2019 дата публикации

CHROMATOGRAM DATA PROCESSING METHOD AND DEVICE

Номер: US20190011408A1
Автор: NODA Akira
Принадлежит: SHIMADZU CORPORATION

Wavelength spectrums of peaks detected on a chromatogram based on observation data to be processed are extracted to create a spectrum set in which the intensity values of the spectrums are normalized. One wavelength spectrum is selected from the set, and a vector of the wavelength spectrum at each point in time of measurement based on the observation data is projected so as to be perpendicular to the vector of the selected spectrum. The vectors of the wavelength spectrums in the set are also similarly projected. Consequently, the selected spectrum is erased from the set. The processes are repeated until the set does not include a spectrum, and the obtained signals are added. The signal resulting from the addition is a signal indicating the waveform shape of an unknown baseline. 16-. (canceled)7. A chromatogram data processing method that processes three-dimensional chromatogram data collected for a sample to be measured and having a time axis , a signal intensity axis , and a third parameter axis , the chromatogram data processing method comprising:acquiring a spectrum corresponding to each of a plurality of peaks detected on a chromatogram created based on the three-dimensional chromatogram data to be processed, the spectrum indicating a relation between a third parameter value and a signal intensity value; andestimating step of estimating a waveform shape of a baseline chromatogram indicating a baseline in the chromatogram based on a time series signal, by projecting a multi-dimensional vector which is a vector representation of a spectrum at each of a plurality points in time of measurement based on the three-dimensional chromatogram data in a direction perpendicular to a vector of a vector representation of the spectrum obtained at the peak spectrum acquiring step, and calculating a magnitude of a projection vector obtained accordingly as the time series signal.8. The chromatogram data processing method of claim 7 , further comprising:estimating a baseline ...

Подробнее
Номер записи: 16
15-01-2015 дата публикации

Process analytic device with improved thermal stability

Номер: US20150013430A1
Автор: Edward J. Bailey, Leighton M. Fields, Steven S. Black
Принадлежит: Rosemount Analytical Inc

A process analytic device includes an input to receive a sample of interest and an analytic detector operably coupled to receive the sample of interest. An analytic output is provided relative to the sample of interest. A plurality of heat pipes is thermally coupled to the analytic detector.

Подробнее
Номер записи: 17
09-01-2020 дата публикации

Parallel Separation and Washing in Size Exclusion Chromatography Separation or in Desalting of a Target from a Sample

Номер: US20200011841A1
Автор: Eriksson Christer Olof
Принадлежит:

Systems and methods are provided for performing washing of columns in a simulated moving bed chromatography system while separation is being performed in the system. 1. A method for performing size exclusion chromatography separation (SEC) or desalting of a target from a sample in a system comprising:i) providing a system with at least three columns at least two of which are connectable in series at the same time;ii) connecting in series a column containing the target with another of the columns; andiii) washing at least one further column with a washing fluid at the same time as the target is being transported by a flow of buffer from said column containing the target to said another of the columns.2. The method according to claim 1 , further comprising the subsequent step of connecting the outlet of said another column to the inlet of the washed further column and subsequently collecting the target from the outlet of the washed column.3. The method according to claim 1 , further comprising the steps of transporting the target in series from the outlet of said another column in any order through said washed further column and one or more additional columns claim 1 , and finally collecting the target from the last additional column or the washed further column.4. The method in accordance with for a size exclusion chromatography (SEC) or desalting system wherein said at least three columns comprise four columns for separating a target from a sample claim 1 , wherein the target passes through three or four columns before being collected claim 1 , wherein each column has an inlet and an outlet fluidly connectable to a valve arrangement for selectively simultaneously connecting said at least two chromatography columns in series and one of the other chromatography columns to flow of washing fluid claim 1 , wherein said valve arrangement comprises a first inlet for inputting a buffer solution claim 1 , a second inlet for inputting a washing fluid claim 1 , an inlet for ...

Подробнее
Номер записи: 18
03-02-2022 дата публикации

MATERIALS FOR HYDROPHILIC INTERACTION CHROMATOGRAPHY AND PROCESSES FOR PREPARATION AND USE THEREOF FOR ANALYSIS OF GLYCOPROTEINS AND GLYCOPEPTIDES

Номер: US20220034852A1
Автор: Iraneta Pamela C., Koza Stephan M., Lauber Matthew A., Wyndham Kevin D.
Принадлежит:

The invention relates to poly-amide bonded hydrophilic interaction chromatography (HILIC) stationary phases and novel HILIC methods for use in the characterization of large biological molecules modified with polar groups, known to those skilled in the art as glycans. The invention particularly provides novel, poly-amide bonded materials designed for efficient separation of large biomolecules, e.g. materials having a large percentage of larger pores (i.e. wide pores). Furthermore, the invention advantageously provides novel HILIC methods that can be used in combination with the stationary phase materials described herein to effectively separate protein and peptide glycoforms by eliminating previously unsolved problems, such as on-column aggregation of protein samples, low sensitivity of chromatographic detection of the glycan moieties, and low resolution of peaks due to restricted pore diffusion and long intra/inter-particle diffusion distances. 149-. (canceled)50. A method for analyzing a glycosylated proteinaceous sample , comprising contacting the sample with a chromatographic material in the presence of a mobile phase eluent to thereby analyze the sample , wherein the chromatographic material is a porous material which comprises at least one hydrophilic monomer and a poly-amide bonded phase.51. The method of claim 50 , wherein an average pore diameter of the porous material is greater than or equal to about 200 Å.52. The method of claim 50 , wherein an average pore diameter of the porous material is ranges from about 200 Å to about 450 Å.53. The method of claim 50 , wherein the porous material has an average pore diameter of about 300 Å.54. The method of claim 50 , wherein the mobile phase eluent is a high organic eluent.55. The method of claim 50 , wherein the mobile phase eluent comprises acetonitrile claim 50 , isopropanol claim 50 , n-propanol claim 50 , methanol claim 50 , ethanol claim 50 , butanol claim 50 , water claim 50 , or a mixture thereof.56. The ...

Подробнее
Номер записи: 19
21-01-2016 дата публикации

SEALING SYSTEM AND METHOD FOR THE PRODUCTION THEREOF

Номер: US20160018001A1
Автор: EICHHORN Thomas Armin Alexander, SATZINGER Adolf
Принадлежит:

The invention relates to a seal for high pressure applications, in which a static and a dynamic sealing portion are separated from each other by a material thin point in such a manner that plastic flowing through the thin point is suppressed even if one of the two sealing portions is acted upon under high pressure as far as elastic compression.

Подробнее
Номер записи: 20
17-01-2019 дата публикации

Process and system for sample analysis

Номер: US20190017873A1
Автор: Anthony S. Bonanno, Martin L. Spartz, Peter P. Behnke
Принадлежит: Mls Acq Inc

Components resolved in time by a separator accumulate in a sample cell and are analyzed by electromagnetic radiation-based spectroscopic techniques. The sample cell can be configured for multiple path absorption and can be heated. The separator can be a gas chromatograph or another suitable device, for example a distillation-based separator. The method and system described herein can include other mechanical elements, controls, procedures for handling background and sample data, protocols for species identification and/or quantification, automation, computer interfaces, algorithms, software or other features.

Подробнее
Номер записи: 21
21-01-2021 дата публикации

Thermal desorbers

Номер: US20210018409A1
Автор: Richard K. Chun
Принадлежит: Hamilton Sundstrand Corp

A thermal desorber assembly includes a housing and a desorption heater element mounted in the housing with a sample cavity defined between the desorption heater element and an inner wall of the housing. An outlet port is defined in the housing. A flow channel connects the sample cavity in fluid communication with the outlet port for conveying analytes from the sample cavity to the outlet port for introducing the analytes to a spectrometer.

Подробнее
Номер записи: 22
16-01-2020 дата публикации

GAS CHROMATOGRAPH

Номер: US20200018732A1
Автор: KOMORI Yuki, TAKECHI Ryo
Принадлежит: SHIMADZU CORPORATION

A gas chromatograph includes a sample introduction portion and a heater block. A contact portion is fit into a first recess of a main body of the sample introduction portion. The heater block is fixed to and positioned with respect to the main body of the sample introduction portion by directly coming into contact with the contact portion provided on the main body of the sample introduction portion. For this reason, the heater block may be surely positioned with respect to the sample introduction portion. In addition, the heater block may be positioned without providing a member such that heat from the heater block is transferred to the outside and lost, and thus the sample introduction portion may be efficiently heated. 1. A gas chromatograph comprising:a sample introduction portion in which a sample vaporization chamber for vaporizing a sample is formed;a heater block that heats the sample introduction portion from an outside; anda positioning mechanism that positions the heater block with respect to the sample introduction portion by bringing the heater block into contact with a contact portion provided on the sample introduction portion.2. The gas chromatograph according to claim 1 , wherein the heater block is a tubular member claim 1 ,the sample introduction portion is inserted into the heater block along an axis direction, andthe positioning mechanism positions the heater block with respect to the sample introduction portion while interposing both end portions of the heater block in the axis direction.3. The gas chromatograph according to claim 1 , wherein the positioning mechanism is allowed to change a relative position of positioning of the heater block with respect to the sample introduction portion.4. The gas chromatograph according to claim 3 , 'the positioning mechanism is allowed to change the relative position of positioning of the heater block with respect to the sample introduction portion by bringing the heater block into contact with the contact ...

Подробнее
Номер записи: 23
16-01-2020 дата публикации

SECONDARY ULTRASONIC NEBULISATION

Номер: US20200018733A1
Автор: Bajic Stevan, Douce David S., Jones Gordon A.
Принадлежит: MICROMASS UK LIMITED

A secondary ultrasonic nebulisation device is disclosed comprising: a liquid sample delivery capillary; a sample receiving surface arranged for receiving a liquid sample from the capillary; and an ultrasonic transducer configured for oscillating the surface so as to nebulise the liquid sample received thereon, wherein the device is configured such that the oscillations of the surface by the ultrasonic transducer cause charged droplets and/or gas phase ions to be generated from the sample. 120-. (canceled)21. A mass or ion mobility spectrometer comprising: a liquid sample delivery capillary;', 'a sample receiving surface arranged for receiving a liquid sample from the capillary; and', 'an ultrasonic transducer configured for oscillating the surface so as to nebulise the liquid sample received thereon, wherein the device is configured such that the oscillations of the surface by the ultrasonic transducer cause charged droplets and/or gas phase ions to be generated from the sample;, 'a secondary ultrasonic nebulisation device comprisinga vacuum chamber;an ion inlet orifice arranged between the sample receiving surface of the nebulisation device and the vacuum chamber, for receiving said charged droplets and/or ions;a structural component arranged in a flow path of the nebulised droplets and/or ion; anda heater configured to heat the structural component.22. The mass or ion mobility spectrometer of claim 21 , wherein the structural component is arranged in the vacuum chamber.23. The mass or ion mobility spectrometer of claim 22 , wherein the structural component is arranged in the flow path of the charged droplets and/or ions such that claim 22 , in use claim 22 , the droplets and/or ions impact onto the structural component.24. The mass or ion mobility spectrometer of claim 22 , wherein the structural component comprises a heated bead.25. The mass or ion mobility spectrometer of claim 22 , wherein the heater heats the structural component such that claim 22 , in use ...

Подробнее
Номер записи: 24
17-04-2014 дата публикации

Flow Cell Assembly for Liquid Sample Analyzer

Номер: US20140104605A1
Автор: David M. Aikens, Gregory Hanlon, Joseph L. DiCesare, Richard Edwards, Timothy Neal
Принадлежит: PerkinElmer Health Sciences Inc

A flow cell assembly for use in a liquid sample analyzer including a radiation source, a sensing device and a liquid sample source to supply a liquid sample includes an entrance joint member, a liquid core waveguide, a liquid sample feed tube, and an input optical fiber. The entrance joint member includes a waveguide receiving bore and a feed tube receiving bore. The liquid core waveguide is mounted in the waveguide receiving bore and defines a waveguide bore. The liquid sample feed tube is mounted in the feed tube receiving bore such that the liquid sample feed tube is in fluid communication with the waveguide bore to fluidly connect the liquid sample source to the waveguide bore. The input optical fiber is mounted in the entrance joint member to transmit radiation from the radiation source to the waveguide bore, which radiation is transmitted through the waveguide bore and the liquid sample therein to the sensing device.

Подробнее
Номер записи: 25
16-01-2020 дата публикации

In-vehicle biochemical sensors

Номер: US20200020514A1
Автор: Paul Timothy FANSON
Принадлежит: Toyota Motor Engineering and Manufacturing North America Inc

The devices, systems, and methods described herein generally relate to chemical profiling of an occupant in a vehicle. The devices, systems and methods described herein can detect enclosure-related chemicals, the enclosure-related chemicals including biochemicals expelled by one or more occupants. The enclosure-related chemicals can then be associated to an associated occupant of the one or more occupants. A biological profile can then be created for the associated occupant, the biological profile comprising medical information and historical information related to the enclosure-related chemicals.

Подробнее
Номер записи: 26
28-01-2016 дата публикации

Diaphragm Valve with Sealing Assembly, Chromatographic System Including Same and Method of Operation Thereof

Номер: US20160025688A1
Автор: Gamache Yves
Принадлежит: MECANIQUE ANALYTIQUE INC.

A valve having a valve cap with a plurality of process conduits extending therethrough, each one of the plurality of process conduits ending in a process port at a valve cap interface. The valve also has a valve body defining a valve body interface facing the valve cap interface, a diaphragm positioned between the valve cap interface and the valve body interface, across the process ports, and a purge line provided through one of the valve cap and the valve body. The valve further comprises a sealing assembly located in the valve body. The sealing assembly is configured and positioned to block fluid leaked through the diaphragm such that the fluid leaked through the diaphragm is discharged via and exit of the purge line of the valve. A chromatographic system including the valve and a method of operation thereof are also provided. 1. A valve comprising:a valve cap having a plurality of process conduits extending therethrough, each one of the plurality of process conduits ending in a process port at a valve cap interface;a valve body defining a valve body interface facing the valve cap interface, the valve body comprising an upper section and a lower section;a diaphragm positioned between the valve cap interface and the valve body interface, across the process ports;a purge line provided through one of the valve cap and the valve body, the purge line having an entry and an exit;a plurality of plungers, each one of the plurality of plungers being positioned in a corresponding plunger passage of a plurality of plunger passages formed in the valve body and being movable between a closed position where the plunger engages the diaphragm, and an open position where the plunger is disengaged from the diaphragm;an actuation system for moving each one of the plurality of plungers between the closed position and the open position, the actuation system comprising an upper piston and a lower piston actuated by an actuating mechanism; anda sealing assembly located in the valve body ...

Подробнее
Номер записи: 27
26-01-2017 дата публикации

Systems and Methods for Conserving Carrier Gas

Номер: US20170023534A1
Автор: Edward B. Mccauley
Принадлежит: Thermo Finnigan LLC

A device for a gas chromatograph system includes an injector, a conduit assembly, a flow restrictor, and a pressure controller. The injector is connected to a carrier gas source and an auxiliary gas source. The conduit assembly surrounds the input end of an analytical column. A carrier gas is supplied at a constant pressure through a flow restrictor to the injector. A pressure controller is configured to control the pressure of an auxiliary gas supplied to the injector from the auxiliary source. The pressure controller is configured to operate in a first mode to provide a first auxiliary gas pressure sufficient to force a flow of the auxiliary gas and a sample onto the analytical column during an inject phase and to operate in a second mode to provide a second auxiliary gas pressure below a threshold necessary to flow auxiliary gas into the analytical column during a resolving phase.

Подробнее
Номер записи: 28
26-01-2017 дата публикации

Modular Multiple-Column Chromatography Cartridge

Номер: US20170023536A1
Автор: BRANN John E.
Принадлежит:

A method for liquid chromatography comprises steps of: mixing a sample comprising a plurality of chemical constituents with a first solvent; transferring the solvent and the plurality of constituents to a first chromatographic column housed in a cartridge; chromatographically separating a sub-group of the plurality of constituents from unwanted constituents using the first chromatographic column; transferring the sub-group of the plurality of constituents from the first chromatographic column to a second column housed in the cartridge, the transferring effected by the flow of a second solvent; chromatographically separating, from one another, individual constituents of the sub-group of the plurality of constituents using the second chromatographic column; and transferring the separated individual constituents to a detector. 1mixing a sample comprising a plurality of chemical constituents with a first solvent;transferring the solvent and the plurality of constituents to a first chromatographic column housed in a cartridge;chromatographically separating a sub-group of the plurality of constituents from unwanted constituents using the first chromatographic column;transferring the sub-group of the plurality of constituents from the first chromatographic column to a second column housed in the cartridge, the transferring effected by the flow of a second solvent;chromatographically separating, from one another, individual constituents of the sub-group of the plurality of constituents using the second chromatographic column; andtransferring the separated individual constituents to a detector.. A method for liquid chromatography comprising: This application is a Divisional application of U.S. patent application Ser. No. 13/882,116, having a 371(c) date of May 2, 2013, which is the United States National Stage application, under 35 U.S.C. 371, of International Application PCT/US2011/058229 having an international filing date of Oct. 28, 2011, which claims the benefit of the ...

Подробнее
Номер записи: 29
10-02-2022 дата публикации

POLYPEPTIDE TARGETING APTAMERS FOR CHARACTERIZATION, CAPTURE, AND CLINICAL MANAGEMENT OF CIRCULATING TUMOR CELLS

Номер: US20220041696A1
Автор: Gordon Erlinda M., Hall Frederick L.
Принадлежит:

Provided herein are new compositions and methods to target and deliver agents to pathological areas by utilizing multifunctional compounds. These compounds include three or more domains: (i) a vimentin-binding peptide, (ii) a linker, and (iii) a drug binding, a capturing reagent, or a detectable moiety. These compounds can be used to detect, isolate, and/or treat cancerous cells such as circulating tumor cells. 1. A compound comprising:a first domain comprising a vimentin-binding peptide;a second domain comprising a linker; anda third domain selected from the group consisting of a detectable moiety, a capture reagent, and a drug binding domain, wherein the linker links the first domain and the third domain.233-. (canceled)3537-. (canceled)38. A method of detecting cancer , a tumor , or circulating tumor cells (CTSs) in a sample , the method comprising:contacting the sample with a compound, wherein the compound comprises (i) a first domain comprising a vimentin-binding peptide; (ii) a second domain comprising a linker; and (iii) a third domain comprising a detectable moiety; anddetecting the compound, to thereby detect cancer, a tumor, or circulating tumor cells CTCs) in the sample.3946-. (canceled)47. A method of diagnosing cancer in a subject , the method comprising: a first domain comprising a vimentin-binding peptide;', 'a second domain comprising a linker; and', 'a third domain comprising a detectable moiety;, 'contacting a sample with a compound, wherein the compound comprisesdetecting the compound in the sample; anddiagnosing the subject as having cancer when the levels of the compound in the sample are increased when compared to a reference sample.48. A method of determining the stage of a cancer , the method comprising: a first domain comprising a vimentin-binding peptide;', 'a second domain comprising a linker; and', 'a third domain comprising a detectable moiety;, 'contacting a sample with a compound, wherein the compound comprisesdetecting the compound in ...

Подробнее
Номер записи: 30
24-01-2019 дата публикации

GAS TESTING UNIT AND METHOD

Номер: US20190024133A1
Автор: Bourdakos Nicholas, Bromley Jason Carl, Heijstra Bjorn Daniel, Simpson Sean Dennis, Yap Kai-Ming
Принадлежит:

Apparatuses and associated methods are described for the efficient evaluation of C1-containing substrates, and especially for such evaluation conducted locally, or on-site, at a prospective facility for implementation of a biological conversion process for desired end product using a C1 carbon source. The exact composition of a given, industrial C1-containing substrate, as well as the range in composition fluctuations, are generally difficult to reproduce at a remote facility (e.g., a laboratory or a pilot-scale or demonstration-scale process), as required for the accurate prediction/modeling of commercial performance to justify large capital expenditures for commercial scale-up. 1. A gas testing unit , comprising:a first bioreactor stage for evaluating the performance of a reference C1-containing substrate;a second bioreactor stage for evaluating the performance of a test C1-containing substrate;an analytical section configured for analysis of both gaseous and liquid products of the first and second bioreactors;{'sup': '3', 'wherein the gas testing unit is capable of being housed within a container having a volume of less than about 6 mand transportable to multiple locations.'}2. The gas testing unit of claim 1 , wherein the gas testing unit is capable of being housed within a box having length claim 1 , width claim 1 , and height dimensions of less than about 1.8 meters each.3. The gas testing unit of claim 2 , wherein the box has length claim 2 , width claim 2 , and height dimensions of less than about 1.6 meters each.4. The gas testing unit of claim 3 , wherein the box has one of the length claim 3 , width claim 3 , and height dimensions of less than about 1.6 meters claim 3 , and the other two of the length claim 3 , width claim 3 , and height dimensions of less than about 1.3 meters.5. The gas testing unit of claim 1 , wherein the analytical section comprises a gas chromatography (GC) analyzer having first and second chromatography columns configured claim 1 , ...

Подробнее
Номер записи: 31
29-01-2015 дата публикации

Controlling interdetector band broadening

Номер: US20150027203A1
Автор: Steven P. Trainoff
Принадлежит: Wyatt Technology LLC

Methods and apparatus for controlling interdetector band broadening during the analysis of a sample injected into a chromatography system. A column flow is diluted with a dilution flow after the sample exits the chromatography system, and the diluted sample is analyzed by one or a combination of analysis instruments such as a light scattering detector, refractive index detector, an ultraviolet absorption detector.

Подробнее
Номер записи: 32
29-01-2015 дата публикации

ANALYTICAL METHODS FOR ANALYZING AND DETERMINING IMPURITIES IN DIANHYDROGALACTITOL

Номер: US20150027206A1
Автор: Lu Xiaoyun
Принадлежит:

An improved analytical method for analysis of dianhydrogalactitol preparations provides a method for determining the purity of dianhydrogalactitol and detecting impurities in preparations of dianhydrogalactitol, as well as identifying any such impurities. The method employs high performance liquid chromatography (HPLC), in particular, HPLC with refractive index (RI) detection; the HPLC can be followed by tandem mass spectroscopy. The method can further comprise the step of performing preparative HPLC collection of at least one specific substance peak present in a preparation of dianhydrogalactitol. 1. An analytical method for analyzing the presence and quantity of impurities present in a preparation of dianhydrogalactitol comprising the steps of:(a) analyzing a preparation of dianhydrogalactitol by subjecting the preparation to high performance liquid chromatography using elution with a mobile phase gradient to separate dianhydrogalactitol from dulcitol and other contaminants of the preparation; and(b) determining the relative concentration of one or more peaks resolved by high performance liquid chromatography that represent compounds other than dianhydrogalactitol itself.2. The method of wherein the compounds other than dianhydrogalactitol itself are at least one of: (1) dulcitol; (2) an impurity other than dulcitol; and (3) a degradation product of dianhydrogalactitol.3. The analytical method of wherein elution is with a gradient of NaOH from about 2.5 mM to about 0.1 mM.4. The analytical method of wherein elution is with a gradient of NaOH from about 1.5 mM to about 0.1 mM.5. The analytical method of wherein elution is with a gradient of NaOH from about 1 mM to about 0.1 mM.6. The analytical method of wherein elution is with a gradient of a combination of ammonium hydroxide and a volatile ammonium salt selected from the group consisting of ammonium formate and ammonium acetate and the total concentration of the ammonium hydroxide and the volatile ammonium salt ...

Подробнее
Номер записи: 33
24-01-2019 дата публикации

AUTOMATED THERMAL DESORPTION SYSTEMS AND METHODS

Номер: US20190025263A1
Автор: Tipler Andrew, Tolley Samuel
Принадлежит:

According to embodiments of the technology, an automated thermal desorption system includes a sample tube including a chamber to contain an analyte, visible indicia on the sample tube, a thermal desorption apparatus, and a sample tube monitoring system. The thermal desorption apparatus is configured to receive the sample tube and includes a heating device. The heating device is configured to heat the sample tube in the thermal desorption apparatus and thereby desorb the analyte from the sample tube. The sample tube monitoring system includes: an optical sensor configured to read the visible indicia on the sample tube and to generate an output signal corresponding thereto; and a controller configured to receive the output signal corresponding to the visible indicia from the optical sensor and to determine an orientation of the sample tube with respect to the thermal desorption apparatus based on the output signal. 1. An automated thermal desorption system including:a sample tube including a chamber to contain an analyte;visible indicia on the sample tube;a thermal desorption apparatus configured to receive the sample tube and including a heating device, wherein the heating device is configured to heat the sample tube in the thermal desorption apparatus and thereby desorb the analyte from the sample tube; and 'an optical sensor configured to read the visible indicia on the sample tube and to generate an output signal corresponding thereto; and', 'a sample tube monitoring system includinga controller configured to receive the output signal corresponding to the visible indicia from the optical sensor and to determine an orientation of the sample tube with respect to the thermal desorption apparatus based on the output signal.2. The automated thermal desorption system of wherein the visible indicia is a barcode.3. The automated thermal desorption system of wherein the barcode is substantially permanently located on the sample tube.4. The automated thermal desorption ...

Подробнее
Номер записи: 34
02-02-2017 дата публикации

Thermal Conductivity Detector

Номер: US20170030873A1
Автор: Gellert Udo
Принадлежит:

A thermal conductivity detector which includes a measurement channel, an electrically heatable heating filament extending longitudinally along the center of the measurement channel so that a fluid passing through the measurement channel flows around the filament, an evaluator that detects electrical resistance changes of the heating filament and provide an output representative of the presence and amount of various fluid components passing the heating filament, and a bypass channel for bypassing the measurement channel, where the bypass channel has a lower fluidic resistance than the measurement channel and where, in order to improve the detection capability, the thermal conductivity detector further includes a flow sensor for measuring the flow of the fluid in the bypass channel and for providing an output indicative of the measured flow, and a correcting device for correcting the output of the evaluator using the output of the flow sensor. 111.-. (canceled)12. A thermal conductivity detector comprising:a measurement channel;an electrically heatable heating filament extending longitudinally along a center of the measurement channel such that a fluid passing through the measurement channel flows around the filament;an evaluator which detects electrical resistance changes of the heating filament and provides an output representing a presence and amount of various fluid components flowing around the heating filament;a bypass channel for bypassing the measurement channel, said bypass channel having a lower fluidic resistance than the measurement channel;a flow sensor for measuring the flow of the fluid in the bypass channel and for providing an output indicative of the measured flow of the fluid; andcorrecting means for correcting the output of the evaluator using an output of the flow sensor.13. The thermal conductivity detector of claim 12 , wherein the flow sensor is a thermal type flow sensor.14. The thermal conductivity detector of claim 12 , wherein the flow ...

Подробнее
Номер записи: 35
01-02-2018 дата публикации

MEANS AND METHODS FOR MINIMIZING SWEPT AND DEAD VOLUMES IN CHROMATOGRAPHIC APPLICATIONS

Номер: US20180031528A1
Автор: KULAK Nils, MANN Matthias
Принадлежит:

The present invention relates to a device for preventing band broadening and remixing of separated fractions, and associated method, comprising a chromatographic column coupled to a flow selector, such as a rotary valve, wherein said flow selector is connected to the distal end of said column such that the sum of post-column swept volume and post-column dead volume is less than 10 μL. Preferably, the column is directly plugged into the inlet port of the rotary valve and the sample is fractionated at the outlet port. 1. A device comprising or consisting of(a) a chromatographic column; and(b) a flow selector,wherein said flow selector is connected to the distal end of said column such that the sum of post-column swept volume and post-column dead volume is less than 10 μL.2. A kit comprising or consisting of(a) a chromatographic column; and(b) a flow selector,wherein said column and said flow selector are configured for a connection of said flow selector to the distal end of said column such that the sum of post-column swept volume and post-column dead volume is less than 10 μL.3. The kit of , furthermore comprising a manual comprising instructions for assembly of a device according to .4. The device of of the kit of or , wherein said chromatographic column(a) is empty; or(b) is filled with chromatographic material;and/orhas an inner diameter of less than 2 mm; preferably of 250 μm or less; or 200 μm or lessand/orhas a volume of 2 mL or less, preferably 100 μL or less.54. The device or kit of claim (b) , wherein said chromatographic material is selected from reversed phase , ion exchange , normal phase , hydrophilic interaction , affinity and size exclusion material.6. The device of any one of , or , or the kit of any one of to , wherein said selector is an n-way rotor valve , n preferably being 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 or 24.7. The device of any one of or to , or the kit of any one of to , ...

Подробнее
Номер записи: 36
17-02-2022 дата публикации

A CLOUD-PLATFORM BASED AUTOMATIC IDENTIFICATION SYSTEM AND METHOD OF SEVEN TYPES OF MASS SPECTRUMS FOR PESTICIDES AND CHEMICAL POLLUTANTS COMMONLY USED IN THE WORLD

Номер: US20220050092A1
Автор: BAI Ruobin, CHANG Qiaoying, Chen Hui, FAN Chunlin, PANG Guofang, WU Xingqiang, ZHANG Zijuan
Принадлежит:

A cloud server platform end is used to construct a mass spectrum species classification model, extract a mass spectrum data feature, and construct a training model of the convolutional neural network; a user platform end is used to upload the mass spectrum, experiment condition and device data, directly screen and identify the type of the mass spectrum based on the mass spectrum species classification model or the mass spectrum information base, automatically compare and identify the species and name of the pesticides based on the neural network model trained by the cloud server platform end, and feedback the comparison result to the user. The disclosure solves the restriction on the purchase of standards for user, the use of the system is not limited by the location, and the pesticide residues could be detected automatically, quickly and accurately. 1. A cloud-platform based identification system of seven types of mass spectrums for pesticides and chemical pollutants commonly used in the world , including a cloud server platform end and a user platform end ,wherein the cloud server platform end includes:a spectrum acquisition unit, which is used to acquire mass spectrum;a spectrum parameter acquisition unit, which is used to acquire the experiment environment, experiment condition, and experiment parameter data corresponding to the mass spectrum;a spectrum device acquisition unit, which is used to acquire information of the spectrum detection device corresponding to the mass spectrum;a spectrum pretreatment unit, which is used to longitudinally splice and pretreat the acquired mass spectrum and extract the spectrum features; anda pesticide species classification model unit, which is used to train the extracted spectrum features, spectrum detection device information and experimental parameter data by neural network model and to obtain the classification model which can identify the species and/or names of pesticides and chemical pollutants;and wherein the user ...

Подробнее
Номер записи: 37
01-02-2018 дата публикации

System for radiopharmaceutical production

Номер: US20180033510A1
Автор: Mark Duncan TARN, Mohammad Mehdi Nasr ESFAHANI, Nathan Joel BROWN, Nicole Pamme, Ping He, Richard Alexander, Stephen James Archibald, Stephen John Haswell
Принадлежит: UNIVERSITY OF HULL

Certain embodiments of the present invention relate to a system and a method for producing a radiopharmaceutical, wherein the system is formed from and/or provides a microfluidic flow system. In certain embodiments, the system comprises a radioisotope isolation module, a radiopharmaceutical production module, a purification module and a quality control module.

Подробнее
Номер записи: 38
04-02-2021 дата публикации

SAMPLE DISPATCHING WITH FLUIDIC SAMPLE RETAINING

Номер: US20210033572A1
Автор: Glauner Thomas, Ortmann Thomas
Принадлежит:

A sample dispatcher for a fluid separation apparatus includes a sampling path including a sampling volume, a sampling unit, and a retaining unit. The sampling unit receives a fluidic sample, and the sampling volume temporarily stores an amount of the received sample. The retaining unit receives and retains from the sampling volume at least a portion of the stored sample, and has different retention characteristics for different components of the sample. A switching unit is coupled to the sampling path, a sampling fluid drive, a mobile phase drive, and a separating device. In a feed injection configuration of the switching unit, the mobile phase drive, the separating device, and the sampling path are coupled together in a coupling point for combining a flow from the sampling fluid drive containing the fluidic sample retained by the retaining unit with a flow of the mobile phase from the mobile phase drive. 1. A sample dispatcher for a fluid separation apparatus , wherein the fluid separation apparatus comprises a mobile phase drive , configured for driving a mobile phase , and a separating device configured for separating a portion of a fluidic sample when comprised within the mobile phase , the sample dispatcher comprising: the sampling unit is configured for receiving the fluidic sample,', 'the sampling volume is configured for temporarily storing an amount of the received fluidic sample, and', 'the retaining unit is configured for receiving and retaining from the sampling volume at least a portion of the fluidic sample stored in the sampling volume, wherein the retaining unit comprises different retention characteristics for different components of the fluidic sample; and, 'a sampling path comprising a sampling volume, a sampling unit, and a retaining unit, whereina switching unit coupling to the sampling path, a sampling fluid drive, the mobile phase drive, and the separating device,wherein the sampling fluid drive is configured for moving at least a portion of ...

Подробнее
Номер записи: 39
08-02-2018 дата публикации

CPC DISTRIBUTION CHROMATOGRAPHY OF CANNABINOIDS

Номер: US20180036278A1
Автор: Rutz Andreas
Принадлежит: Bionorica Ethics GmbH

The invention relates to cannabinoids and their isolation and purification and to obtaining them by means of centrifugal partition chromatography. 111.-. (canceled)12. A method for separating and/or purifying cannabinoids from a cannabis extract , including at least one liquid-liquid centrifugal partition chromatography step , wherein a solvent from the group of cyclohexane , heptane , or octane is selected and is kept stationary by centrifugal force , including and a second non-miscible liquid phase.13. The method for separating and/or purifying cannabinoids from a cannabis extract according to claim 12 , wherein the first phase is n-heptane.14. The method for separating and/or purifying cannabinoids from a cannabis extract according to claim 12 , wherein the second phase is acetonitrile claim 12 , methanol claim 12 , ethylacetate or water.15. The method for separating and/or purifying cannabinoids from a cannabis extract according to claim 12 , selected from the group consisting of:n-heptane/acetonitrile, n-heptane/ethylacetate/acetonitrile, n-heptane/ethylacetate/t-butyl methyl ether/acetonitrile,n-heptane/ethylacetate/methanol/water,n-heptane/methanol/water, n-heptane/ethanol/water,n-heptane/acetone/water, n-heptane/methanol/acetonitrile,n-heptane/ethanol/acetonitrile,n-heptane/acetone/acetonitrile,n-heptane/chloroform/acetonitrile,n-heptane/chloroform/methanol, n-heptane/methanol,n-heptane/ethanol/methanol,n-heptane/n-butanol/acetonitrile, n-heptane/2-propanol/water, n-heptane/n-propanol/water, n-heptane/2-propanol/acetonitrile, n-heptane/n-propanol/acetonitrile, n-heptane/dichloromethane/acetonitrile,n-heptane/dichloromethane/methanol,n-heptane/tetrahydrofuran/acetonitrile,n-heptane/benzotrifluoride/acetonitrile, Cyclohexane/methanol/water,Cyclohexane/methanol/acetonitrile,Cyclohexane/t-butyl methyl ether/water, Cyclohexane/acetonitrile/water, andIsooctane/methanol, isooctane/methanol/water, Isooctane/ethyl acetate/methanol/water.16. The method for separating ...

Подробнее
Номер записи: 40
07-02-2019 дата публикации

GAS CHROMATOGRAPH

Номер: US20190041368A1
Автор: Kashihara Minoru, NAKAMA Yuji, SHIBAMOTO Shigeaki
Принадлежит: SHIMADZU CORPORATION

Provided is a gas chromatograph including a column which separates a sample; a detector which is configured to alternately introduce a carrier gas containing a sample component separated by the column and a carrier gas alone into a detection unit by changing an inflow point of the carrier gas to acquire a signal; an analysis information input unit with which analysis information is input; a data retaining unit which retains data indicating a relationship between a column flow rate and a carrier gas flow rate which is obtained in advance; and calculation unit which is configured to calculate the carrier gas flow rate on the basis of the analysis information input from the analysis information input unit and calculate the carrier gas flow rate according to the calculated column flow rate by using the calculated column flow rate and the data retained in the data retaining unit. 1. A gas chromatograph comprising:a column which separates a sample;a detector which is configured to alternately introduce a carrier gas containing a sample component separated by the column and a carrier gas alone into a detection unit by changing an inflow point of the carrier gas to acquire a signal;an analysis information input unit with which analysis information is input;a data retaining unit which retains data indicating a relationship between a column flow rate and a carrier gas flow rate which is obtained in advance; anda calculation unit which is configured to calculate the column flow rate on the basis of the analysis information input from the analysis information input unit and calculate the carrier gas flow rate according to the calculated column flow rate by using the calculated column flow rate and the data retained in the data retaining unit.2. The gas chromatograph according to claim 1 , wherein the analysis information is at least one of an inner diameter of the column claim 1 , a length of the column claim 1 , a temperature claim 1 , and a pressure applied to the column.3. ...

Подробнее
Номер записи: 41
06-02-2020 дата публикации

Hybrid capillary/packed trap and method of use

Номер: US20200041469A1
Автор: Daniel B. CARDIN
Принадлежит: Entech Instruments Inc

A hybrid trap including a replaceable open-tubular capillary trap followed by a packed trap is used to collect, preconcentrate, and recover a sample, such as VOCs and SVOCs found in air. The capillary stage prevents losses and carryover of the heavy fraction and can also collect the particles in air that contain the heavier SVOCs, also preventing them from reaching the packed stage. The packed stage traps lighter organic compounds that are not as prone to carryover due to channeling. The capillary and packed traps together provide quantitative recovery of compounds boiling from as low as −50° C. to as high as 600° C. The sample can be directly desorbed onto the GC column, which avoids losses and contamination caused by other approaches that thermally desorb samples through transfer lines and rotary valves more remote to the GC oven.

Подробнее
Номер записи: 42
16-02-2017 дата публикации

Portable water quality instrument

Номер: US20170045453A1
Автор: Mark C. Peterman, Merwan Benhabib, Samuel Kleinman
Принадлежит: OndaVia Inc

A hand-held microfluidic testing device is provided that includes a housing having a cartridge receiving port, a cartridge for input to the cartridge receiving port having a sample input and a channel, where the channel includes a mixture of Raman-scattering nanoparticles and a calibration solution, where the calibration solution includes chemical compounds capable of interacting with a sample under test input to the cartridge and the Raman-scattering nanoparticles, and an optical detection system in the housing, where the optical detection system is capable of providing an illuminated electric field, where the illuminating electric field is capable of being used for Raman spectroscopy with the Raman-scattering nanoparticles and the calibration solution to analyze the sample under test input to the cartridge.

Подробнее
Номер записи: 43
15-02-2018 дата публикации

SOLVENT PREHEATING SYSTEM FOR LIQUID CHROMATOGRAPHY

Номер: US20180045689A1
Автор: Keenan Paul, KHEYFETS Greg, Linderson Paul E., Shreve Joshua A.
Принадлежит:

A heater assembly used in chromatography includes a thermally conductive base having a chamber extending fully through the base with an opening at a first side of the base and at a second side of the base, and a cavity with an opening at the second side of the base. A heater is disposed within the cavity in thermal communication with the base. A thermistor assembly, having a thermistor within a thermally conductive body is disposed within the chamber. The body has a head region with a planar surface. The planar surface of the head region is exposed at the opening of the chamber at the first side of the base for making thermally conductive contact therewith. The thermistor assembly is thermally isolated from the base. 1. A heater assembly for use in chromatography , comprising:a thermally conductive base having a first side, a second side opposite the first side, a chamber extending fully through the base with an opening at the first side of the base and at the second side of the base, and a cavity with an opening at the second side of the base;a heater disposed within the cavity in thermal communication with the base; anda thermistor assembly disposed within the chamber, the thermistor assembly having a thermistor within a thermally conductive body, the body having a head region with a planar surface, the thermistor assembly being disposed within the chamber such that the planar surface of the head region is exposed at the opening of the chamber at the first side of the base for making thermally conductive contact therewith, the chamber being wider than the head region of the body such that the thermistor assembly is thermally isolated from the base.2. The heater assembly of claim 1 , wherein the body further comprises a neck region adjacent the head region; and the thermistor assembly further comprises a spring disposed around the neck region of the body between the head region and a surface within the chamber to produce a force that urges the planar surface of the ...

Подробнее
Номер записи: 44
15-02-2018 дата публикации

SYSTEMS AND METHODS FOR CHARACTERIZING RADIOACTIVE ANALYTES

Номер: US20180045692A1
Автор: Elizarov Arkadij M.
Принадлежит:

A device for automated characterization of radioactive analytes that provides an integrated system with liquid handling and plate reading components. The device can be further configured to include a chromatographic subsystem. Also provided is a method of using such a device, providing addition of a radioactive sample and a sequence of operations involving the abovementioned components of the system. The system is configured with radiation shielding in such a way that manipulations of radioactive samples do not interfere with concurrent radioactive measurements. 1. A device for performing an analysis , comprising:a plate reader; anda liquid handler,wherein at least a portion of the liquid handler is positioned above the plate reader.2. The device of claim 1 , further comprising a radiation shield claim 1 ,wherein the radiation shield is interposed between the liquid handler and the plate reader.3. The device of claim 1 , further comprising a radiation shield claim 1 ,wherein at least a portion of the radiation shield is positioned within a portion of the device selected from the group consisting of the liquid handler and the plate reader.4. The device of wherein the device is configured for analysis of a radiopharmaceutical.5. The device of wherein the device is configured to operate in combination with a palette.6. The device of claim 1 , wherein the liquid handler is configured to deliver a liquid to locations within the plate reader.7. A method for automated sample analysis claim 1 , comprising the steps of transferring a liquid using a liquid handler and obtaining an optical reading.8. The method of wherein the optical reading is performed utilizing an optical reader characterized by being sensitive to background radiation.9. The method of wherein the optical reading is unaffected by a radiation source located in the liquid handler.10. An injection device for performing an analysis of a sample claim 8 , comprising a chromatographic injection device that is ...

Подробнее
Номер записи: 45
13-02-2020 дата публикации

INJECTING A LIQUID BORNE SAMPLE INTO A FIELD FLOW FRACTIONATOR

Номер: US20200049671A1
Автор: Trainoff Steven P.
Принадлежит: WYATT TECHNOLOGY CORPORATION

The present invention an apparatus and method of injecting a liquid borne sample into a field flow fractionator and a method of forming a top plate and spacer. In an embodiment, the field flow fractionation unit includes a top plate including a sample injection inlet port, a sample injection outlet port, and a spacer including a separation channel cavity defining at least a portion of the separation channel, a sample injection inlet cavity configured to be in fluid contact with the separation channel and located substantially beneath the sample injection inlet port, a sample injection outlet cavity configured to be in fluid contact with the separation channel and located substantially beneath the sample injection outlet port, such that the injection inlet and outlet paths are configured to define an injection channel that is essentially perpendicular to the length of the separation channel spanning the width of the separation channel cavity. 1. A field flow fractionation unit comprising: a sample injection inlet port configured to allow a liquid borne sample to be injected into a separation channel,', 'a sample injection outlet port configured to allow liquid contained within the separation channel to be withdrawn; and, 'a top plate comprising'} [ 'wherein the separation channel is defined by a surface of the top plate, sidewalls of the spacer, and a surface of a membrane,', 'a separation channel cavity defining at least a portion of the separation channel,'}, 'wherein the sample injection inlet cavity is configured to act as an injection inlet path,', 'a sample injection inlet cavity configured to be in fluid contact with the separation channel and located substantially beneath the sample injection inlet port,'}, 'wherein the sample injection outlet cavity is configured to act as an injection outlet path,', 'a sample injection outlet cavity configured to be in fluid contact with the separation channel and located substantially beneath the sample injection outlet ...

Подробнее
Номер записи: 46
25-02-2021 дата публикации

Method in Bioprocess System

Номер: US20210057049A1
Автор: Gunnar Malmquist, Per Liden
Принадлежит: Cytiva Bioprocess R&D AB

The present invention relates to a method for estimating performance of a bioprocess material when used in a bioprocess system. The bioprocess material comprising at least two ingredients, each having data properties. The method comprises: i) obtaining (81) the data properties for the at least two ingredients used to produce the bioprocess material; ii) defining (82) procedures to process the at least two ingredients; iii) processing (83) the at least two ingredients according to the defined process parameters to obtain at least a product; iv) measuring (84) data properties of each product, v) calculating (85) data properties of each product based on the measured data properties of each product and/obtain or data properties from the at least two ingredients, and vi)if the product is the bioprocess material, processing (88) the measured and calculated data properties to estimate the impact of the bioprocess material on a target product in the bioprocess system, or vii) if the product is not the bioprocess material, treating the product as an intermediate material and repeating (87) steps iii)-vi) with each product as one of the at least two ingredients.

Подробнее
Номер записи: 47
05-03-2015 дата публикации

COLUMN OVEN AND LIQUID CHROMATOGRAPH

Номер: US20150059450A1
Автор: TAKAHASHI Kazuya
Принадлежит: SHIMADZU CORPORATION

A column oven includes a main unit, an auxiliary unit, an outside sensor, an internal sensor, a temperature range holding section for holding a plurality of temperature ranges, a temperature range specifying portion for specifying the temperature range to which the outside temperature belongs, a temperature control program holding section for holding a temperature control program for a control method of the main unit and the auxiliary unit in each temperature range in such a way that outputs of the main unit and the auxiliary unit are continuous in the temperature ranges that are adjacent to each other, a control method setting portion for setting a control method of the main unit and the auxiliary unit based on the temperature range specified and the temperature control program, and a temperature control portion for controlling the main unit and the auxiliary unit. 1. A column oven comprising:a housing including inside a temperature adjusting space for accommodating an analytical column;a main unit for heating and cooling the analytical column in the temperature adjusting space;an auxiliary unit, provided separately from the main unit, for heating the analytical column in the temperature adjusting space;an outside sensor for detecting an outside temperature that is a temperature outside the housing;an internal sensor for detecting an inside temperature that is a temperature inside the temperature adjusting space;a set temperature holding section for holding a set temperature that is a target value of a temperature of the analytical column;a temperature range holding section for holding a plurality of continuous temperature ranges in a temperature scope in which the outside temperature possibly changes;a temperature range specifying portion for specifying, among the temperature ranges of the temperature range holding section, the temperature range to which the outside temperature detected by the outside sensor belongs;a temperature control program holding section ...

Подробнее
Номер записи: 48
10-03-2022 дата публикации

SAMPLE INJECTION DIAPHRAGM VALVE

Номер: US20220074504A1
Автор: Lemelin Simon, Lessard Joël
Принадлежит:

A sample injection diaphragm valve is provided, as well as a plunger assembly and a method of operating the valve. The valve includes a valve head and a valve body. The valve includes a diaphragm positioned between the valve head and the valve body. The diaphragm has a process groove seated in the recess of the valve body for circulating fluid therein. Plungers are slidably fitted in plunger passages of the valve body. Each plunger is movable between a closed position wherein the plunger deforms the diaphragm and blocks fluid circulation between two process ports, and an open position wherein the plunger is retracted away from the diaphragm, thereby allowing fluid to circulate in the process groove. The plungers have linear lips extending across the top face of the plungers for pressing against the diaphragm when in the closed position. 1. A sample injection diaphragm valve for channeling fluid therein , comprising:a valve head comprising a plurality of process conduits extending therethrough, each of the process conduits ending in a process port;a valve body facing the valve head, the valve body comprising a body interface provided with a recess, the valve body also comprising plunger passages extending therein, said plunger passages opening on the recess;a diaphragm positioned between the valve head and the valve body and having a process groove seated in the recess of the valve body, for circulating fluid therein; anda normally closed plunger assembly and a normally open plunger assembly, provided between within the valve body, each assembly comprising plungers slidably fitted in the plunger passages of the valve body, each plunger being movable between a closed position wherein the plunger deforms the diaphragm and blocks fluid circulation between two of the process ports, and an open position wherein the plunger is retracted away from the diaphragm, allowing fluid to circulate, the plunger having a head with a top face, the top face being provided with a linear ...

Подробнее
Номер записи: 49
10-03-2022 дата публикации

Analysis System and Method Employing Thermal Desorption and Spectrometric Analysis

Номер: US20220074852A1
Автор: Anthony S. Bonanno, Charles M. Phillips, Martin L. Spartz, Peter P. Behnke
Принадлежит: Mls Acq Inc

Components resolved in time by a thermal desorption separator accumulate in a sample cell and are analyzed by electromagnetic radiation-based spectroscopic techniques.

Подробнее
Номер записи: 50
10-03-2022 дата публикации

PORTABLE WATER QUALITY INSTRUMENT

Номер: US20220074862A1
Автор: BENHABIB Merwan, Kleinman Samuel, Peterman Mark C.
Принадлежит:

A hand-held microfluidic testing device is provided that includes a housing having a cartridge receiving port, a cartridge for input to the cartridge receiving port having a sample input and a channel, where the channel includes a mixture of Raman-scattering nanoparticles and a calibration solution, where the calibration solution includes chemical compounds capable of interacting with a sample under test input to the cartridge and the Raman-scattering nanoparticles, and an optical detection system in the housing, where the optical detection system is capable of providing an illuminated electric field, where the illuminating electric field is capable of being used for Raman spectroscopy with the Raman-scattering nanoparticles and the calibration solution to analyze the sample under test input to the cartridge. 1. A portable testing device comprising:a. a housing, wherein said housing comprises a cartridge receiving port;b. a cartridge for input to said cartridge receiving port, wherein said cartridge contains a mixture including a water sample comprising an analyte, Raman-scattering nanoparticles and a calibration solution, wherein said calibration solution comprises a chemical compound capable of interacting with the analyte and the Raman-scattering nanoparticles; andc. an optical detection system in said housing, wherein said optical detection system is capable of providing an illuminated electric field, wherein said illuminating electric field is capable of being used for Raman spectroscopy with said Raman-scattering nanoparticles and said calibration solution to analyze said sample under test input to said cartridge,wherein the chemical compound is selected from the group consisting of thiols, amines, silanes, polymeric particles, metallic particles, crown esters, cysteamine, cystamine, diethylaminethanethiol, mercaptopropionic acid, 1-propanethiol, octanethiol, octyldecanethiol, polystyrene, iron, and silica.2. A portable testing device comprising:a. a housing, ...

Подробнее
Номер записи: 51
10-03-2022 дата публикации

HEATER INTEGRATED GAS CHROMATOGRAPHY COLUMN DEVICE

Номер: US20220074898A1
Автор: AHN Jong Rok, KIM Jae-Ha, Kim Taeman, Park Han-Oh
Принадлежит:

A heater integrated gas chromatography (GC) column device according to the present invention is capable of precisely and uniformly controlling a temperature by having a high thermal conductivity, and raising and lowering a temperature at a high speed by having a low thermal mass, such that a measuring time is significantly decreased. The GC column is in contact with a bobbin with a homogeneous temperature distribution, and thus a temperature is homogeneously distributed in each GC column. Further, the heater integrated GC column device according to the present invention has the above-described effects and may have a smaller size. 1. A heater integrated gas chromatography (GC) column device comprising:a bobbin formed of a metal having a high thermal conductivity;an insulating layer including a metal oxide film formed on an inner surface of the bobbin;a heat generating layer bonded to the insulating layer and including any one or more selected from the group consisting of carbon nanotubes and a carbon nanotube-metal composite;a metal electrode formed to be in contact with the heat generating layer; anda GC column wound around the bobbin while being adjacent to an outer surface of the bobbin.2. The heater integrated GC column device of claim 1 , further comprising a bonding layer formed between the outer surface of the bobbin claim 1 , and the GC column.3. The heater integrated GC column device of claim 2 , wherein the bonding layer is formed of a heat-resistant silicone or an epoxy resin.4. The heater integrated GC column device of claim 2 , wherein an average thickness of the bonding layer is 10 to 500 μm.5. The heater integrated GC column device of claim 1 , wherein the metal having a high thermal conductivity is selected from the group consisting of copper claim 1 , magnesium claim 1 , aluminum and alloys thereof.6. The heater integrated GC column device of claim 1 , wherein the insulating layer is a metal oxide film formed by anodizing the inner surface of the ...

Подробнее
Номер записи: 52
20-02-2020 дата публикации

Method for Adapting UV Cell Pathlength in a Chromatography System

Номер: US20200054964A1
Автор: Hanno Ehring, Hans Blom, Helena Skoglar, Linda MATHIASSON, Mikael Berg, Rebecka CHMIELOWSKI
Принадлежит: GE Healthcare Bio Sciences AB, Merck Sharp and Dohme LLC

The present invention relates to a method for determining operational status of a chromatography column (1; 39, 47, 59; 107, 109, 111, 113), comprising detecting a feed signal (21; 201) representative of the composition of a feed material provided to the inlet of the column; detecting the UV absorbance in the feed material, detecting an effluent signal (23; 203, 205, 207, 209) representative of the composition of the effluent from the column; and using the feed signal and the effluent signal to determine operational status of the column. The feed signal is generated using a first UV detector having a first UV cell pathlength operating at a first UV wavelength and in the effluent signal is generated using a second UV detector having a second UV cell pathlength operating at a second UV wavelength. The method further comprising determining a first threshold value based on the detected UV absorbance in the feed material, and selecting the first UV cell pathlength and/or first UV wavelength based on the first threshold value.

Подробнее
Номер записи: 53
03-03-2016 дата публикации

Automated analysis systems

Номер: US20160061787A1
Автор: Neil VASDEV, Thomas Lee Collier
Принадлежит: General Hospital Corp

The disclosure relates to systems and methods for performing high performance liquid chromatography (HPLC) on a liquid sample. The methods include automatically, using a computer, controlling a liquid sample including a plurality of components to flow through a first flow path in a system for HPLC. Flowing through the first flow path includes flowing the liquid sample through a capture column. The capture column is capable of trapping at least some of the components of the liquid sample. The method includes automatically, using the computer, controlling a solvent to flow through a second flow path in the system for HPLC. Flowing through the second flow path includes flowing the solvent through the capture column to elute the trapped components from the capture column; flowing the solvent and eluted components through an analysis column capable of separating the eluted components; and flowing the separated components to a detector.

Подробнее
Номер записи: 54
01-03-2018 дата публикации

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY METHOD FOR ANALYSIS OF MN DIAGNOSTIC AND THERAPEUTIC LIGAND AND PRECURSOR

Номер: US20180059072A1
Автор: Chang Yu, HSU CHENG-FANG, LU Kuei-Lin, TSAI JIA-DONG
Принадлежит:

A high performance liquid chromatography method for analysis of a MN diagnostic and therapeutic ligand and precursors is revealed. Polarity of eluents used during elution is changed to remove impurities. First use a first eluent with a lower ratio of acetonitrile as a mobile phase to elute analytes. Then a second eluent in which a ratio of acetonitrile is increased into 97˜99% is used to elute the analytes for at least 20 minutes. Next use the first eluent to elute the analytes for at least 60 minutes. Thus no residual impurities are left in the column and the analytes remain in the column stably. Therefore a more accurate and reproductive result is obtained. 2. The method as claimed in claim 1 , wherein a weight percent of the trifluoroacetic acid solution is ranging from 0.1% to 1%.3. The method as claimed in claim 1 , wherein a volume ratio of the acetonitrile in the first eluent is 35˜85%.4. The method as claimed in claim 1 , wherein a volume ratio of the acetonitrile in the second eluent is 97˜99%.5. The method as claimed in claim 1 , wherein a flow rate in the mobile phase elution is ranging from 0.5 ml/min to 1 ml/min.6. The method as claimed in claim 1 , wherein in the step of using a first eluent to elute the MN diagnostic and therapeutic ligand claim 1 , time required for the step is at least 20 minutes.7. The method as claimed in claim 1 , wherein in the step of using a second eluent to elute the MN diagnostic and therapeutic ligand claim 1 , time required for the step is at least 20 minutes.8. The method as claimed in claim 1 , wherein in the step of lastly using the first eluent again to elute the MN diagnostic and therapeutic ligand claim 1 , time required for the step is at least 60 minutes.9. The method as claimed in claim 1 , wherein a detection wavelength of the UV detector is 210 nm.11. The method as claimed in claim 10 , wherein a weight percent of the trifluoroacetic acid solution is ranging from 0.1% to 1%.12. The method as claimed in claim 10 ...

Подробнее
Номер записи: 55
02-03-2017 дата публикации

COOLING-ASSISTED INSIDE NEEDLE CAPILLARY ADSORPTION TRAP DEVICE FOR ANALYZING COMPLEX SOLID SAMPLES USING NANO-SORBENT

Номер: US20170059533A1
Автор: Ghiasvand Alireza, Yazdankhah Fatemeh, Zarghami Farzaneh
Принадлежит:

A cooling-assisted inside needle capillary adsorption trap device for sampling and delivering volatile and semi-volatile analytes to an analytical device is disclosed. The device includes an inside needle capillary adsorption trap having a first end and a second end and a side aperture located between the first and second ends. The side aperture enables entering the carrier gas into the INCAT and flowing upon the surface of the sorbent (when injected into the GC injector) for complete releasing and eluting of the analytes from the interior surface of the needle. A sorbent is multiwall carbon nanotube/polyaniline and is coated onto the interior surface of the needle between the second end and the side aperture to entrap an analyte within a sample. The cooling-assisted inside needle capillary adsorption trap device also includes a cooling device configured to cool the sorbent. 1. A cooling-assisted inside needle capillary adsorption trap system comprising:a needle including a first end and a second end and a side aperture positioned between the first end and the second end, and the side aperture being configured to enter the carrier gas into an interior surface of the needle INCAT for complete releasing and eluting of the analytes from the interior surface of the needle;a MWCNT/PANI nanocomposite sorbent coated into the interior surface of the needle between the second end and the side aperture and configured to entrap the analytes within a sample received within the interior space of the needle; anda cooling device configured to cover and cool the sorbent and includes an inner tube and an outer tube, the outer tube having a diameter larger than the inner tube and including a first aperture and a second aperture;a first capillary tube coupled to the first aperture and configured to be an inlet channel for a coolant fluid for cooling the sorbent; anda second capillary tube coupled to the second aperture and configured to be an outlet channel for the coolant fluid, ...

Подробнее
Номер записи: 56
20-02-2020 дата публикации

Gas phase standard preparation device and method to use

Номер: US20200057040A1
Автор: Markle Doug
Принадлежит:

This invention is a preparation station for creating a certified reference material. The certified reference material is used to compare the air within an area or room. This is beneficial for identifying if the air within the area contains certain volatile compounds or otherwise undesired compounds. This is accomplished by providing a sealed ampule containing chemical compounds that is eventually broken by the gas preparation device. Once the ampule is broken a gas cylinder the contents are mixed with a diluent gas and forced into a reference material cylinder. The contents within the cylinder are verified and certified for use in testing the air quality of the area or room. Accordingly, with the use of a sealed premade ampule, this invention allows for creating a custom reference material as needed and also eliminates the need for shipping compressed gas cylinders for air quality testing. 1. A gas phase standard preparation device which is comprised of: wherein the housing has a first lid and a second lid;', 'wherein the first lid is hinged to the housing;', 'wherein the second lid is hinged to the housing;, 'a. a housing;'} wherein the sealed ampule tube is further comprised of an ampule, a sleeve, a plurality of spacers, a first compression fitting, a second compression fitting, a first end, and a second end;', 'wherein the ampule is provided within the sleeve;', 'wherein the plurality of spacers is provided within the sleeve;, 'b. a sealed ampule tube;'} wherein the gas supply line has a first end and a second end;', 'wherein the second end of the gas supply line is linked to the first end of the sealed ampule tube;, 'c. a gas supply line;'} wherein the pressure sensor is linked to the first end of the gas supply line;', 'wherein the pressure sensor is provided in the housing;, 'd. a pressure sensor;'} wherein the vacuum pump valve is linked to the pressure sensor;', 'wherein the vacuum pump valve is provided in the housing;, 'e. a vacuum pump valve;'} wherein ...

Подробнее
Номер записи: 57
17-03-2022 дата публикации

Techniques for system suitability testing of inert liquid chromatography systems and columns

Номер: US20220082531A1
Автор: Amit Patel, Jennifer Simeone, Kevin Wyndham, Mathew DELANO, Matthew A. Lauber, Moon Chul Jung, Susan Rzewuski, Thomas H. Walter
Принадлежит: Waters Technologies Corp

The present disclosure is directed to methods of characterizing a system containing a chromatographic column. The methods can include introducing a sample comprising a positive control and a negative control to the system containing a chromatographic column, wherein the positive control is a sensitive probe that interacts with the system and the negative control is substantially non-interacting with the system; after passing the sample through the chromatographic column, detecting the positive control and the negative control; and determining system suitability by comparing the amount of detected positive control to negative control. In some embodiments, determining system suitability (e.g., inertness of sample to the system) is accomplished by determining a ratio of detected positive control to negative control.

Подробнее
Номер записи: 58
27-02-2020 дата публикации

GLYCOSYNTHASE VARIANTS FOR GLYCOPROTEIN ENGINEERING AND METHODS OF USE

Номер: US20200062861A1
Автор: HSIEH Yih Huang, HSIEH Yin-Cheng, HU Pu-Ling, HUANG Teng-Yi, TSAI Yi-chien, WANG NAN-HSUAN, YU Cheng-Der Tony
Принадлежит:

The present disclosure relates to novel glycosynthase enzymes for glycoprotein engineering and/or homogeneous antibody remodeling. The enzyme variants, termed EndoSd-D232M and EndoSz-D234M, contain the glycan conjugation and/or modification activity at the conserved N297 glycosylation site of Fc region of an exemplary antibody. It has been demonstrated that the glycosynthase activities of EndoSd-D232M and EndoSz-D234M can be applied to various mAbs targeting different receptors, including, but not limited to, Globo H, SSEA-4, SSEA-3 series of receptors (OBI-888; Globo H ganglioside), Herceptin (Her 2 receptor), Perjeta (Her 2 receptor) and Vectibix (EGFR receptor). It has been found that both mAb-GlcNAc and mAb-GlucNAc(F) were suitable substrates for both EndoSd-D232M and EndoSz-D234M. The ADCC assay of related products, OBI-888-G2S2 and Herceptin-G2S2, showed that the remodeled homogeneous antibody, mAb-G2S2, has an increased relative activity ranging from 3 to 26 folds. 1. A mutant of glycosynthase comprising:an amino acid sequence of at least about 80% sequence homology to the amino acid sequence set forth in the sequence of SEQ ID NO. 1 oran amino acid sequence of at least about 80% sequence homology to the amino acid sequence set forth in the sequence of SEQ ID NO. 2.2. The mutant of glycosynthase of claim 1 , wherein the one or more mutations are in a peptide region located within residues 176-186 claim 1 , residues 225-237 claim 1 , residues 273-289 in the sequence of SEQ ID NO. 1 orin a peptide region located within residues 178-188, residues 227-239, residues 275-291 in the sequence of SEQ ID NO. 2.3. The mutant of glycosynthase of claim 2 , wherein the residue is substituted with a neutral amino acid claim 2 , hydrophobic amino acid claim 2 , acidic amino acid or a basic amino acid claim 2 ,4. A method for preparing an engineered glycoprotein using the glycosynthase mutant of - comprising coupling of an activated oligosaccharide to a glycoprotein acceptor. ...

Подробнее
Номер записи: 59
09-03-2017 дата публикации

Portable spectroscopic analysis tool

Номер: US20170067863A1
Автор: Ranjith Kunnath Narayanan
Принадлежит: Individual

A portable spectroscopy analysis tool tests food for herbicides, pesticides, growth hormones, carcinogens, and other materials. Due to the broad range of herbicides, pesticides, growth hormones, carcinogens, and other materials which may be subjects of concern for the user, and the immediate need for accurate test results based on a small sample, the tool preferably employs gas chromatography-mass spectrometry (GC-MS). Alternate embodiments, employing alternate methods of chromatography such as liquid chromatography (LC), are contemplated. The user dissolves a small shaving of a food sample into a volatile solvent, such as alcohol, and dips a test strip into the resulting solution. The strip is then inserted into an aperture which is provided on the top surface of the tool, and a visual display provides a chemical analysis of the sample within seconds.

Подробнее
Номер записи: 60
09-03-2017 дата публикации

METHODS OF EVALUATING QUALITY OF MEDIA SUITABLE FOR REMOVING ANTI-A OR ANTI-B ANTIBODIES

Номер: US20170067915A1
Автор: Bian Nanying, Rahane Santosh, Stone Matthew T., Turiano Matthew
Принадлежит:

Embodiments described herein relate to methods of evaluating quality of a chromatography media for removal of anti-A or anti-B antibodies from a sample, where the methods employ use of purified Lectins. 3. The method of claim 1 , wherein the solid support is a porous or non-porous polymeric solid support comprising a polymer selected from the group consisting of polyvinylether claim 1 , polyvinylalcohol claim 1 , polymethacrylate claim 1 , polyacrylate claim 1 , polystyrene claim 1 , polyacrylamide claim 1 , polymethacrylamide and polycarbonate.4. The method of claim 2 , wherein the solid support is a porous or non-porous polymeric solid support comprising a polymer selected from the group consisting of polyvinylether claim 2 , polyvinylalcohol claim 2 , polymethacrylate claim 2 , polyacrylate claim 2 , polystyrene claim 2 , polyacrylamide claim 2 , polymethacrylamide and polycarbonate.5. The method of claim 1 , wherein the solid support is a polyvinylether based porous solid support.6. The method of claim 2 , wherein the solid support is a polyvinylether based porous solid support.7. The method of claim 5 , wherein the polyvinylether based porous solid support is in bead form.8. The method of claim 6 , wherein the polyvinylether based porous solid support is in bead form.9. The method of claim 1 , wherein the binding capacity of the blood group A antigen ligand media for purified HP Lectin correlates with its ability to remove anti-A antibodies from a sample.10. The method of claim 2 , wherein the binding capacity of the blood group B antigen ligand media for purified GSI-B4 Lectin correlates with its ability to remove anti-B antibodies from a sample.11. The method of claim 1 , wherein the two or more affinity chromatography media samples constitute different batches of the same media.12. The method of claim 2 , wherein the two or more affinity chromatography media samples constitute different batches of the same media.13. The method of claim 1 , wherein the ...

Подробнее
Номер записи: 61
19-03-2015 дата публикации

GAS CHROMATOGRAPHY USING A THERMAL GRADIENT THAT IS SUBSTANTIALLY MONOTONICALLY NON-INCREASING AND HAS A POSITIVE SECOND DERIVATIVE

Номер: US20150075374A1
Автор: Lee Milton L., Tolley H. Dennis, Tolley Samuel E., Wang Anzi
Принадлежит:

A system and method for thermal gradient gas chromatography wherein a front or injection end of a column is heated to a higher temperature than a back or detector end to thereby create a thermal gradient having a profile that is substantially monotonically non-increasing and has a positive second derivative, and then providing a heat source to raise the thermal gradient and cause it to remain stationary or to travel through the column while maintaining a desired profile. 1. A method for performing gas chromatography , said method comprising:providing an injector, a column and a detector, the column having a front end for receiving a sample from the injector, and a back end for elution of the sample into the detector;providing a first heating device for applying primary heat to the column to create a thermal gradient along at least a portion of the column wherein at least some portion of the thermal gradient is negative;providing a second heating device for applying secondary heat to the column to thereby raise the thermal gradient of the column; andwherein the thermal gradient is substantially monotonically non-increasing and wherein the thermal gradient has a substantially non-negative second derivative.2. The method as defined in wherein the method of applying the secondary heat to thereby uniformly raise the thermal gradient of the column further comprises controlling the profile of the thermal gradient.3. The method as defined in wherein the method of controlling the profile of the thermal gradient further comprises causing the thermal gradient to maintain the desired profile while translating the thermal gradient to a higher temperature.4. The method as defined in wherein the method further comprises modifying a rate at which the secondary heat translates the thermal gradient to a higher temperature.5. The method as defined in wherein the method of creating the thermal gradient further comprises creating the thermal gradient having at least one segment that is ...

Подробнее
Номер записи: 62
07-03-2019 дата публикации

Mobile integrated device and electronic data platform for chemical analysis

Номер: US20190072529A1
Автор: Alexander Fayek Andrawes, Craig Fontenot, David Cree Crawford, Quan Shi
Принадлежит: Green Ocean Sciences Inc

Systems, methods and computer program products for cannabis analysis, such as a system that has a cannabis analysis data server and a plurality of mobile cannabis analysis devices that are communicatively coupled to a network. The mobile devices perform physical analyses of a physical sample and communicate resulting data to the cannabis analysis data server with a unique identifier. The mobile cannabis analysis devices may also monitor device and external environmental conditions that affect the performance and communicate these to the cannabis analysis data server. The cannabis analysis data server performs analyses on the received data from the mobile devices. Based on the sample analyses, the cannabis analysis data server generates sample analysis reports and communicates them to a user. The cannabis analysis data server may also generate data to control the operation of the mobile cannabis analysis devices based on the operation and environmental data received from the devices.

Подробнее
Номер записи: 63
19-03-2015 дата публикации

CATALYTIC OXIDATION OF POLAR MODIFIERS IN CHROMATOGRAPHIC MOBILE PHASES

Номер: US20150079691A1
Автор: Fogwill Michael O., Michienzi Joseph D., Murphy James P.
Принадлежит: WATERS TECHNOLOGIES CORPORATION

The present disclosure relates to an oxidizer, and related methods, for oxidizing polar modifiers in chromatographic mobile phases. The oxidizer enables the use of flame-based detection in chromatographic separations, such as carbon dioxide based chromatography, which employ polar modifiers, such as methanol. Upon exiting a chromatographic column, the mobile phase containing the polar modifier is flowed through an oxidizer that contains a catalyst to oxidize at least a portion of the polar modifier to a species that does not interfere with the function of the flame-based detector. The oxidizer allows for flame-based detection, such as flame ionization detection, in applications in which a polar modifier with a reduced form of carbon is used. 1. An oxidizer for use in a chromatographic system having a flame-based detector , comprising:(i) an inlet capable of receiving a mobile phase containing a polar modifier;(ii) a chamber in fluid communication with the inlet port, wherein the chamber has a catalyst capable of oxidizing at least a portion of the polar modifier; and(iii) an outlet in fluid communication with the chamber capable of exiting the mobile phase and oxidized polar modifier from the chamber.2. The oxidizer of claim 1 , wherein the mobile phase comprises carbon dioxide.3. The oxidizer of claim 1 , wherein the polar modifier is methanol.4. The oxidizer of claim 1 , wherein the flame-based detector is a flame ionization detector or a flame photometric detector.5. The oxidizer of claim 1 , wherein the catalyst comprises one or more constituents selected from the group consisting of: Ag claim 1 , Au claim 1 , Rh claim 1 , Ni claim 1 , Cd claim 1 , Pt claim 1 , Pd claim 1 , Cu claim 1 , TiO claim 1 , ZnO claim 1 , ZrO claim 1 , and AlO; or combinations claim 1 , alloys claim 1 , or mixtures thereof.6. The oxidizer of claim 1 , further comprising a reagent gas in the chamber.7. The oxidizer of claim 1 , wherein the catalyst is deposited on the surface of a ...

Подробнее
Номер записи: 64
16-03-2017 дата публикации

METHOD AND APPARATUS FOR DETERMINING A CHROMATOGRAM

Номер: US20170074839A1
Автор: Knochenmuss Richard
Принадлежит: Tofwerk AG

The invention relates to a method and an apparatus for determining a chromatogram. The method includes a first step where a sample is inserted in two separation columns (), wherein for each separation column (), a corresponding part of the sample is inserted in the respective separation column () with a corresponding insertion device () which is controlled by a corresponding modulation function for generating a corresponding modulated part of the sample in the respective separation column (), wherein the modulation functions with which the parts of the sample are modulated in the separation columns () differ from each other. Furthermore, the method includes a second step where each modulated part of the sample is guided through the respective separation column (), a third step where a signal of each modulated part of the sample is measured with a same detector () after having passed the respective separation column (), and a fourth step where for each separation column (), a correlation of the signal and the modulation function with which the corresponding part of the sample is modulated in the respective separation column () is calculated in order to determine the chromatogram of the respective separation column (). 1. A method for determining a chromatogram , including:a) a first step where a sample is inserted in two separation columns, wherein for each separation column, a corresponding part of the sample is inserted in the respective separation column with a corresponding insertion device which is controlled by a corresponding modulation function for generating a corresponding modulated part of the sample in the respective separation column, wherein the modulation functions with which the parts of the sample are modulated in the separation columns differ from each other,b) a second step where each modulated part of the sample is guided through the respective separation column,c) a third step where a signal of each modulated part of the sample is measured with a ...

Подробнее
Номер записи: 65
05-03-2020 дата публикации

LIQUID DELIVERY DEVICE AND LIQUID CHROMATOGRAPH EQUIPPED WITH LIQUID DELIVERY DEVICE

Номер: US20200072204A1
Автор: YANAGIBAYASHI Jun
Принадлежит: SHIMADZU CORPORATION

A liquid delivery device includes at least one liquid delivery pump that delivers liquid, at least one main channel communicating with an outlet of the liquid delivery pump, at least one branch channel branched from the main channel, and a switching valve that has, as a port for connecting channels, at least a port to which the main channel is connected, a port to which the branch channel is connected, at least one output port for outputting liquid delivered by the liquid delivery pump through the main channel, and at least one drain port leading to a drain, and is configured to be selectively switched to a first state, in which the main channel is connected to the output port while the branch channel is not connected to any channel, and a second state in which the branch channel is connected to the drain port while the main channel is not connected to any channel. 110-. (canceled)11. A liquid delivery device comprising:at least one liquid delivery pump for delivering liquid;at least one main channel communicating with an outlet of the liquid delivery pump;at least one branch channel branched from the main channel; anda switching valve comprising, as a port for connecting channels, at least a port to which the main channel is connected, a port to which the branch channel is connected, at least one output port for outputting liquid delivered by the liquid delivery pump through the main channel, and at least one drain port leading to a drain, the switching valve is configured to be selectively switched to a first state and a second state, the first state is a state in which the main channel is connected to the output port while the branch channel is not connected to any channel, and the second state is a state in which the branch channel is connected to the drain port while the main channel is not connected to any channel.12. The liquid delivery device according to claim 11 , further comprising:a plurality of mixers whose capacities are different from each other, and ...

Подробнее
Номер записи: 66
05-03-2020 дата публикации

Optical flow cell assembly incorporating a replaceable transparent flow cell

Номер: US20200072747A1
Автор: David Rahmlow, Matthew Greenstreet, Shiladitya Sen
Принадлежит: Wyatt Technology LLC

A new liquid flow cell assembly for light scattering measurements is disclosed which utilized a floating manifold system. The assembly operates with minimal stacked tolerances by aligning the cell to the windows within a manifold and independently aligning the cell to the read head directly. This configuration enables the ability to replace the flow cell or the flow cell/manifold assembly within a light scattering instrument without the need to realign the flow through elements with the light scattering illumination source while still maintaining reproducible, quality data. Some embodiments employ wide bore cells which enable the measurement of process analytic technology (PAT) including online monitoring of reactions.

Подробнее
Номер записи: 67
05-03-2020 дата публикации

Monitoring method, monitoring device, and monitoring system for monitoring a state of a chromatography apparatus

Номер: US20200072804A1
Автор: Riko Tsukamoto, Takashi Inoue
Принадлежит: Yokogawa Electric Corp

A non-transitory computer readable medium (CRM) storing computer readable program code for monitoring a state of a chromatography apparatus embodied therein that: receives one or more monitoring conditions that each include a determination condition for parameters related to measurements taken using the chromatography apparatus; and displays, in parallel and using a combination operational expression: a first conditional expression based on at least one of the monitoring conditions that make up a first combined conditional expression, wherein the first combined conditional expression is based on a first combined monitoring condition that combines all of the received monitoring conditions, and a second conditional expression based on at least one of the monitoring conditions associated with the first conditional expression.

Подробнее
Номер записи: 68
12-06-2014 дата публикации

System and method for rapid analysis of polymer additives

Номер: US20140157871A1
Автор: Andrew AUBIN, Baiba CABOVSKA, Michael Jones, Peter Hancock, Stephan DUBANT
Принадлежит: Waters Technologies Corp

The subject technology is directed to a CO 2 -based chromatography system and method for rapid determination of the levels and/or the presence or absence of polymer additives (PAs) leachable or extractable from packing materials or implantable medical devices.

Подробнее
Номер записи: 69
26-03-2015 дата публикации

Diaphragm-Sealed Valve with Improved Actuator Design

Номер: US20150083259A1
Автор: Gamache Yves
Принадлежит: MECANIQUE ANALYTIQUE INC.

A valve comprising a valve cap, a valve body and a diaphragm positioned between the valve cap and the valve body. The valve further has a plurality of plungers movable, by an actuation system, between a closed position where the plunger engages the diaphragm, and an open position where the plunger is disengaged from the diaphragm. Each plunger comprises a base section connected to the actuation system and having a head projecting away therefrom; a top section extending between the base section and the diaphragm, the top section having a foot in contact with the head of the base section; and a biasing mechanism biasing the top section away from the diaphragm when the plunger is in the open position. Tangential contact points may also be provided between components of the actuation and the biasing mechanism for preventing a misalignment of the actuation system within the valve body. 1. A valve comprising:a valve cap having a plurality of process conduits extending therethrough, each one of the plurality of process conduits ending in a process port at a valve cap interface;a valve body having a valve body interface facing the valve cap interface, the valve body having a plurality of plunger passages extending therein;a diaphragm positioned between the valve cap interface and the valve body interface, across the process ports;a plurality of plungers, each one of the plurality of plungers being positioned in a corresponding plunger passage of the plurality of plunger passages and being movable between a closed position where the plunger engages the diaphragm, and an open position where the plunger is disengaged from the diaphragm; andan actuation system for moving each one of the plurality of plungers between the closed position and the open position; (i) a base section connected to the actuation system and having a head projecting away therefrom;', '(ii) a top section extending between the base section and the diaphragm, the top section having a foot in contact with the ...

Подробнее
Номер записи: 70
22-03-2018 дата публикации

HPLC COLUMN

Номер: US20180078877A1
Автор: Farkas Tivadar, Maiefski Romaine R., Rahn Peter C., Welch Emmet E.
Принадлежит:

A slurry chamber is fastened to and held in coaxial alignment with a chromatography column by a V-band. One end of the column has an end cap and frit. A slurry of fluid and chromatographic media is placed in the column and chamber. A piston is forced through the chamber and into the column by a hydraulic ram to expel the fluid and form a media bed in the column. The slurry chamber is removed, and a split end cap is fastened to the column. A threaded recess in the split end cap receives a split, threaded collet. The collet is tightened until it pushes against the piston with the same force as the ram, at which point the ram is released and the column removed for use. 137.-. (canceled)38. A chromatography column having a tubular body with an inner diameter , the column having opposing inlet and outlet ends , the column comprising:a bed of chromatographic media that has just been compressed to its maximum axial compression packing pressure during formation of the chromatographic bed;an upstream and downstream frit inside the tubular body and located on respective upstream and downstream ends of the bed of chromatographic media;a piston having opposing, upstream and downstream ends, the downstream end of the piston urging the upstream frit against the bed of chromatographic media and maintaining the axial compression packing pressure on the bed of chromatographic media, with no spring interposed between the first frit and the piston, the upstream end of the piston having an annular surface encircling a longitudinal axis of the column and facing away from the upstream frit;a fluid seal interposed between the piston and the inner diameter of the tubular body;a locking sleeve with multiple-parts that are connected together to encircle the inlet end of the column, each part of the locking sleeve having sleeve threads located thereon to form a threaded surface encircling the longitudinal axis;an annular locking collet having collet threads located to threadingly engage the ...

Подробнее
Номер записи: 71
22-03-2018 дата публикации

Materials Transport Device for Diagnostic and Tissue Engineering Applications

Номер: US20180078932A1
Автор: Burg Karen J.L., TABBAA Suzanne
Принадлежит:

Devices that can transport biological materials are described. The devices incorporate capillary channeled fibers that can effectively transport living cells as well as other biological materials such as nutrients, growth factors, waste materials, etc. The devices can include a sorptive material at one end of the fibers that can improve transport of materials through the devices. The devices can differentially transport different cell types, particularly when the fibers are held in a vertical orientation. Diagnostic devices that incorporate the capillary channeled fibers are described that can be utilized to separate cell types from one another. Tissue engineering scaffolds that incorporate the capillary channeled fibers are described that can more efficiently transport materials into and out of the scaffolds. 1. A device for transporting biological materials comprising:a plurality of capillary channeled fibers, each capillary channeled fiber having a longitudinal axis along a length of the fiber, an outer surface, and a non-circular cross section that is perpendicular to the longitudinal axis of the fiber, each capillary channeled fiber including a plurality of co-linear open-topped channels extending along the entire length of the fiber, each open-topped channel being open at the outer surface of the fiber, each open-topped channel being defined by two opposed walls, each wall extending in a first direction that is along the length of and parallel to the longitudinal axis of the fiber and each wall also extending in a second direction that is perpendicular to the longitudinal axis of the fiber, with each wall forming a side wall of one channel and each wall forming a part of the exterior surface of an open-topped fiber, the plurality of capillary channeled fibers being held adjacent to one another and generally aligned with one another in a bundle such that at least one closed channel is formed between a first open-topped channel of a first fiber and a second open ...

Подробнее
Номер записи: 72
22-03-2018 дата публикации

FUNCTIONALIZED SUPPORT FOR ANALYTICAL SAMPLE PREPARATION

Номер: US20180080858A1
Автор: Long David, Lucas Derick, Richter Bruce, Zhao Limian
Принадлежит:

Aspects of the present disclosure include a solid phase sorbent for preparation of analytical samples. The solid phase sorbent includes particles that are surface modified with an α-cyclodextrin moiety. Also provided is a method of reducing matrix effects in an analytical sample. In some embodiments, the method includes contacting a sample comprising a matrix-interfering agent and an analyte with α-cyclodextrin modified particles to produce a contacted sample wherein the matrix-interfering agent binds to the α-cyclodextrin modified particles; separating the α-cyclodextrin modified particles from the contacted sample to produce a matrix-reduced composition; and detecting the analyte in the matrix-reduced composition. Systems for practicing the subject methods are provided that include the subject solid phase sorbent. 1. A solid phase sorbent for preparation of analytical samples , comprising particles that are surface modified with an α-cyclodextrin moiety.2. The solid phase sorbent of claim 1 , wherein the α-cyclodextrin moiety is linked to the surface of the silica particles via a carbamate claim 1 , a thiocarbamate claim 1 , an ester claim 1 , an amide claim 1 , a thioamide claim 1 , a urea claim 1 , a thiourea claim 1 , an amino claim 1 , a keto claim 1 , or an ether linking group.4. The solid phase sorbent of claim 1 , wherein the α-cyclodextrin moiety comprises 6-hydroxyl-linked claim 1 , 3-hydroxyl linked and/or 2-hydroxyl linked α-cyclodextrin.5. The solid phase sorbent of claim 1 , wherein the α-cyclodextrin moiety is a modified α-cyclodextrin.7. The solid phase sorbent of claim 6 , wherein:the particles are silica particles;{'sup': 1', '2, 'sub': '2', 'Zand Zare independently selected from —N(R′)C(═O)—, —N(R′)C(═O)O—, —N(R′)C(═S)—, —N(R′)C(═S)O—, —N(R′)C(═O)N(R′)—, —N(R′)C(═S)N(R′)—, —CO—, —CO—, — NR′—, and —O— wherein each R′ is independently H, a lower alkyl or a substituted lower alkyl;'}{'sub': 1', '1', '20', '1', '20', '1', '20', '1', '20', '1', '20', ...

Подробнее
Номер записи: 73
24-03-2016 дата публикации

System and method of preconcentrating analytes in a microfluidic device

Номер: US20160084805A1
Автор: Ryan T. Kelly, Yongzheng Cong
Принадлежит: Battelle Memorial Institute Inc

A method and system for preconcentrating analytes at a microvalve in a microfluidic device is disclosed. The system includes a sample channel loaded with a sample solution. The sample channel includes a semi-permeable membrane microvalve. An electric potential is applied at or across the microvalve to preconcentrate the sample solution when the microvalve is closed. The method includes pretreatments of the device or valve for preconcentration of the analytes. For preconcentration of anionic analytes, the device is baked. For preconcentration of the cationic analytes, the surface of the membrane microvalve is coated with a polycationic coating, and the device is baked.

Подробнее
Номер записи: 74
25-03-2021 дата публикации

Valve Manifolds for Simulated Moving Bed Chromatography

Номер: US20210086101A1
Автор: Bjorn Markus OLOVSSON, Klaus Gebauer
Принадлежит: Cytiva Sweden AB

Disclosed is a device for chromatographic separations comprising: a manifold comprising a manifold body defining an elongate central duct, the central duct comprising a centrally-located closable duct valve providing selective fluid communication between a first portion of the central duct and an opposed second portion of the central duct, a first plurality of connectors, each connector of the first plurality of connectors for connecting to a distinct chromatographic separation column and/or feed or extraction tubing or to a connector of an adjacent manifold; a second plurality of connectors, each connector of the second plurality of connectors for connecting to a distinct chromatographic separation column and/or feed or extraction tubing or to a connector of an adjacent manifold; wherein said manifold body further defines: a first plurality of branch ducts, each branch duct of which extending from the first portion of the central duct to an individual one of the first plurality of connectors, each of the branch ducts of the first plurality of branch ducts comprising a closable branch valve providing selectable fluid communication between a respective connector and the first portion of the central duct, a second plurality of branch ducts, each branch duct of which extending from the second portion of the central duct to an individual one of the second plurality of connectors, each of the branch ducts of the second plurality of branch ducts comprising a closable branch valve providing selectable fluid communication between a respective connector and the second portion of the central duct; first and second ports in fluid communication with the centrally-located closable duct valve wherein said first port communicates with said first portion of the central duct and said second port communicates with said second portion of said central duct, wherein one of said first and second ports is further positioned to communicate with said central duct at a location between the ...

Подробнее
Номер записи: 75
29-03-2018 дата публикации

Chromatography Media And Method

Номер: US20180085743A1
Автор: David Yavorsky, Joaquin Umana, John Amara, Matthew Stone, Mikhail Kozlov, William Cataldo
Принадлежит: EMD Millipore Corp

Adsorptive media for chromatography, particularly ion-exchange chromatography, derived from a shaped fiber. In certain embodiments, the functionalized shaped fiber presents a fibrillated or ridged structure which greatly increases the surface area of the fibers when compared to ordinary fibers. Also disclosed herein is a method to add surface pendant functional groups that provides cation-exchange or anion-exchange functionality to the high surface area fibers. This pendant functionality is useful for the ion-exchange chromatographic purification of biomolecules, such as monoclonal antibodies (mAbs).

Подробнее
Номер записи: 76
29-03-2018 дата публикации

MULTI-INJECTION MODE VALVE MODULE

Номер: US20180088091A1
Автор: Andrews Richard W., Beals Peyton C., Cormier Sylvain
Принадлежит: WATERS TECHNOLOGIES CORPORATION

A chromatography system has an associated system volume and a sample dispersion volume. The chromatography system comprises a pump pumping a flow of gradient, a sample manager for introducing a sample into the flow of gradient, and a valve manager fluidically coupled to the pump and to the sample manager. The valve manager includes at least one valve. A first valve of the at least one valve has a plurality of ports including an inlet port that receives the flow of gradient from the pump and an outlet port through which the flow of gradient exits the first valve. The first valve has at least two different, automatically selectable positions. A first position of the at least two different automatically selectable positions operating to change one of the system and sample dispersion volumes of the chromatography system when the first valve is automatically switched into the first position. 1. A chromatography system having an associated system volume and a sample dispersion volume , the chromatography system comprising:a pump pumping a flow of gradient;a sample manager for introducing a sample to the flow of gradient; anda valve manager fluidically coupled to the pump and to the sample manager, the valve manager including at least one valve, a first valve of the at least one valve having a plurality of ports including an inlet port that receives the flow of gradient from the pump and an outlet port through which the flow of gradient exits the first valve, the first valve having at least two different, automatically selectable positions, a first position of the at least two different automatically selectable positions of the first valve operating to change one of the system and sample dispersion volumes of the chromatography system when the first valve is automatically switched into the first position.2. The chromatography system of claim 1 , further comprising:a valve drive operatively coupled to the first valve; anda processor in communication with the valve drive, ...

Подробнее
Номер записи: 77
21-03-2019 дата публикации

GAS CHROMATOGRAPH MASS SPECTROMETER

Номер: US20190086372A1
Автор: HIRAMATSU Yoshiro, SAKAMOTO Yuki, SUMIYOSHI Takashi
Принадлежит: SHIMADZU CORPORATION

A GC/MS measurement under an ionization by an electron ionization method is performed for a target sample (S). Peaks are detected on a chromatogram based on obtained data, and a mass spectrum corresponding to each peak is compared with a compound database to identify a compound (S-S). A compound identified with a low degree of similarity is extracted as the measurement compound. For this compound, a measurement window including the retention time of a peak corresponding to the compound is set, and a control program for performing an ionization by a chemical ionization method only within the measurement window is created (S-S). According to this control program, a GC/MS measurement for the target sample is performed, with the device controlled so that a reagent gas is supplied into an ionization chamber and a filament for generating thermions is energized within the measurement window, whereas the supply of the reagent gas is discontinued and the filament is deenergized within time ranges other than the measurement window (S). Since no reagent-gas ion is generated within the time ranges other than the measurement window, the adhesion of the ions to the inside of the ionization chamber and other locations will be reduced. Accordingly, a stable measurement can be performed for a long period of time. 1. A gas chromatograph mass spectrometer employing a mass spectrometer as a detector for a gas chromatograph , the mass spectrometer provided with an ion source including: an ionization chamber to which a sample gas is supplied; a thermion generator for generating thermions; and a reagent-gas supplier for supplying a reagent gas into the ionization chamber , the ion source capable of switching between an ionization by an electron ionization method in which a component in a sample gas supplied into the ionization chamber is ionized by making a thermion generated by the thermion generator come in contact with the component , and an ionization by a chemical ionization method ...

Подробнее
Номер записи: 78
21-03-2019 дата публикации

CATALYTIC OXIDATION OF POLAR MODIFIERS IN CHROMATOGRAPHIC MOBILE PHASES

Номер: US20190086373A1
Автор: Fogwill Michael O., Michienzi Joseph D., Murphy James P.
Принадлежит: WATERS TECHNOLOGIES CORPORATION

The present disclosure relates to an oxidizer, and related methods, for oxidizing polar modifiers in chromatographic mobile phases. The oxidizer enables the use of flame-based detection in chromatographic separations, such as carbon dioxide based chromatography, which employ polar modifiers, such as methanol. Upon exiting a chromatographic column, the mobile phase containing the polar modifier is flowed through an oxidizer that contains a catalyst to oxidize at least a portion of the polar modifier to a species that does not interfere with the function of the flame-based detector. The oxidizer allows for flame-based detection, such as flame ionization detection, in applications in which a polar modifier with a reduced form of carbon is used. 120-. (canceled)21. A method of oxidizing a chromatographic mobile phase containing at least one analyte of interest and a compound having a reduced form of carbon , the method comprising:(i) providing a chromatographic system having a separation column, an oxidizer in fluid communication with and downstream of the column, and a flame-based detector in fluid communication with and downstream of the oxidizer; and(ii) oxidizing at least a portion of the mobile phase in the oxidizer, wherein the oxidizer has a catalyst that (a) facilitates the oxidation of at least a portion of the mobile phase to carbon dioxide which does not substantially produce a signal in the flame-based detector and (b) does not permit the complete oxidation of the at least one analyte of interest.22. The method of claim 21 , wherein the mobile phase comprises acetonitrile.23. The method of claim 21 , wherein at least a portion of the mobile phase is oxidized to carbon dioxide.24. The method of claim 21 , wherein the flame-based detector is a flame ionization detector or a flame photometric detector25. The method of claim 21 , wherein the catalyst comprises one or more constituents selected from the group consisting of: Ag claim 21 , Au claim 21 , Rh claim 21 ...

Подробнее
Номер записи: 79
05-05-2022 дата публикации

PREPARATIVE CHROMATOGRAPH SYSTEM

Номер: US20220137007A1
Автор: OWA Michiaki
Принадлежит:

A preparative chromatograph system includes a sample injector () that injects a sample into a separation flow path () through which a mobile phase flows, a separation column () that is provided on the separation flow path () and is to separate a sample injected into the separation flow path () into components, a detector () that is provided at a position farther downstream than the separation column () on the separation flow path () and is to detect sample components obtained by separation in the separation column (), a collector (′) having a plurality of collection containers () for collecting part of an eluate eluted from the separation column () and a switch mechanism () configured to be capable of selectively connecting a downstream end of the separation flow path () to any one of the collection containers (), a collection setter () configured to set a portion, to be collected in each of the collection containers (), of an eluate eluted from the separation column () using a pre-acquired chromatogram of a sample, and a collection setter () configured to be capable of setting a portion, including a sample component, of an eluate eluted from the separation column (), and a portion, between two sample components that are adjacent to each other on the chromatogram, of an eluate eluted from the separation column (), as the portion to be collected, and a controller () configured to control an operation of the switch mechanism () of the collector (′) and collect the portion, which is to be collected and is set by the connection setter (), in the predetermined collection container ().

Подробнее
Номер записи: 80
05-05-2022 дата публикации

Analysis system and analysis execution method

Номер: US20220137011A1
Автор: Andy Sasaki, Keisuke Ogawa, Kerry Hill, Timothy Lee
Принадлежит: Shimadzu Corp

An analysis system is used to together with a sample supplier that supplies a sample, a detector that detects a sample and a display, and includes a plurality of channels arranged in parallel with one another and a display controller that causes a display to display a control screen in regard to control of the plurality of channels. Each channel includes a mobile phase supplier that supplies a mobile phase and an analysis column that separates a sample that has been supplied by the sample supplier into components and guides the components to the detector.

Подробнее
Номер записи: 81
19-03-2020 дата публикации

Thermal conductivity detector and gas chromatograph including same

Номер: US20200088696A1
Автор: Yuji Nakama
Принадлежит: Shimadzu Corp

An upstream portion of a flow path is stored in a cell block. A filament for detecting thermal conductivity of a sample gas is stored in the upstream portion. The sample gas is led to a downstream portion of an exhaust pipe path through the flow path. The flow path is kept warm by a temperature retainer such that the temperature of the sample gas that passes through the exhaust pipe path does not decrease to a temperature equal to or lower than a liquefaction temperature of the sample gas. Alternatively, at least one portion including a downstream end of the exhaust pipe path is provided to be attachable to and detachable from another portion of the flow path.

Подробнее
Номер записи: 82
05-04-2018 дата публикации

Modular-type analysis system

Номер: US20180093201A1
Автор: Kazuya Takahashi, Yusuke Yokoi
Принадлежит: Shimadzu Corp

In the non-volatile storage unit ( 341 ) of the local control unit ( 34 ) of each unit ( 3 to 6 ) configuring an LC system, periodic inspection information, such as the installation date and the next inspection scheduled date, is stored at an appropriate time. When an analysis is carried out, in the system control unit ( 2 ) which controls each unit, a periodic inspection notification processing unit ( 211 ) collects periodic inspection information from each unit ( 3 to 7 ) upon power on or start up, compares the next inspection scheduled date with the current time by the real-time clock ( 212 ), and determines a unit for which a periodic inspection notification is required. If there is a unit that requires a periodic inspection notification, a notification request is sent to the unit, and the local control unit ( 34 ) of the unit outputs an indication prompting periodic inspection to the display unit ( 35 ). As a result, even if the installation times are different for each unit and even if each unit does not have a real-time clock, it is possible to notify a user when a predetermined age of service has passed from the installation time of a given unit.

Подробнее
Номер записи: 83
12-05-2022 дата публикации

An nir based real-time control of loading in protein a chromatography

Номер: US20220146416A1
Автор: Anurag Singh Rathore, Garima Thakur, Vishwanath Hebbi
Принадлежит: INDIAN INSTITUTE OF TECHNOLOGY DELHI

The present invention relates to method of using spectroscopy for real time measuring of concentration of desired product and using measured data for monitoring and control of chromatography. It develops a method and system for measuring real-time concentration of clarified harvest and that of flow through of loading step of the chromatography and using measured data for determining breakthrough in real-time. The two modes of operation are used viz. first mode (Part A) uses a single near infrared spectroscopy (NIR) flow cell prior to the continuous chromatography column to ensure optimal loading in each cycle based on dynamic binding capacity studies carried out previously with the desired Protein A resin and second mode (Part B) uses two near infrared spectroscopy (NIR) flow cells, one before and one after the column, to detect the breakthrough curve (from 1% breakthrough onwards).

Подробнее
Номер записи: 84
12-05-2022 дата публикации

PORTABLE WATER QUALITY INSTRUMENT

Номер: US20220146430A1
Автор: BENHABIB Merwan, Kleinman Samuel, Peterman Mark C.
Принадлежит:

A hand-held microfluidic testing device is provided that includes a housing having a cartridge receiving port, a cartridge for input to the cartridge receiving port having a sample input and a channel, where the channel includes a mixture of Raman-scattering nanoparticles and a calibration solution, where the calibration solution includes chemical compounds capable of interacting with a sample under test input to the cartridge and the Raman-scattering nanoparticles, and an optical detection system in the housing, where the optical detection system is capable of providing an illuminated electric field, where the illuminating electric field is capable of being used for Raman spectroscopy with the Raman-scattering nanoparticles and the calibration solution to analyze the sample under test input to the cartridge. 1. A hand-held microfluidic testing device comprising:a. a housing, wherein said housing comprises a cartridge receiving port;b. a cartridge for input to said cartridge receiving port, wherein said cartridge comprises a sample input and a channel, wherein said channel comprises a mixture of Raman-scattering nanoparticles and a calibration solution, wherein said calibration solution comprises chemical compounds capable of interacting with a sample under test input to said cartridge and said Raman-scattering nanoparticles; andc. an optical detection system in said housing, wherein said optical detection system is capable of providing an illuminated electric field, wherein said illuminating electric field is capable of being used for Raman spectroscopy with said Raman-scattering nanoparticles and said calibration solution to analyze said sample under test input to said cartridge.2. The hand-held microfluidic testing device of claim 1 , wherein said chemical compounds are selected from the group consisting of thiols claim 1 , amines claim 1 , silanes claim 1 , polymeric particles claim 1 , metallic particles claim 1 , crown esters claim 1 , cysteamine claim 1 , ...

Подробнее
Номер записи: 85
12-05-2022 дата публикации

PERFORMING A SEPARATION ON A FIELD FLOW FRACTONATOR

Номер: US20220146464A1
Автор: Trainoff Steven P.
Принадлежит: WYATT TECHNOLOGY CORPORATION

The present disclosure describes a method, a system, and a computer program product of performing a separation on a field flow fractionator. In an embodiment, the method, the system, and the computer program product include executing, by a computer system, a set of logical operations measuring a mass flow control valve position of a control valve connected to a mass flow controller coupled to a field flow fractionator and a pressure control valve position of a control valve connected to a pressure controller coupled to the field fold fractionator in an optimal stability state, storing, by the computer system, the valve positions to a data store as preset values, and executing, by the computer system, a set of logical operations retrieving the preset values from the data store and setting initial conditions for the controllers corresponding to the preset values, resulting in a switch mode of the field flow fractionator. 1. A computer implemented method comprising:executing, by a computer system, a set of logical operations measuring a mass flow control valve position of a control valve connected to a mass flow controller coupled to a field flow fractionator and a pressure control valve position of a control valve connected to a pressure controller coupled to the field fold fractionator in an optimal stability state;storing, by the computer system, the valve positions to a data store as preset values; andin response to receiving, by the computer system, a switch mode command, executing, by the computer system, a set of logical operations retrieving the preset values from the data store and setting initial conditions for the controllers corresponding to the preset values, resulting in a switch mode of the field flow fractionator.2. The method of wherein the switch mode is one of a focus mode claim 1 , an elution mode claim 1 , a focus injection mode claim 1 , and an elution inject mode.3. A computer implemented method comprising: 'wherein the focus flow offset value is ...

Подробнее
Номер записи: 86
26-03-2020 дата публикации

Konditionierung eines Adsorbens

Номер: US20200094222A1
Автор: Beat Schilling, Chiew Mei CHONG, Stefan Anton CRETNIK
Принадлежит: CTC Analytics AG

In a process for thermally desorbing a phase material (20), in particular for conditioning a fiber for carrying out a solid-phase microextraction, the phase material (20) is heated along a temperature curve. The temperature curve of the phase material (20) during desorption includes at least one low point.

Подробнее
Номер записи: 87
12-04-2018 дата публикации

SYSTEM AND METHOD FOR REAL-TIME ISOTOPE IDENTIFICATION

Номер: US20180099249A1
Автор: JR. James L., KRONEWITTER Scott R., Stephenson, Yip Ping F.
Принадлежит:

An embodiment of a method for real time material identification is described that comprises determining an approximate mass value for an unknown material from spectral information derived from mass spectral analysis of the unknown material; retrieving profile models that correspond to a known material from a data structure using the approximate mass value; fitting a sample profile for the unknown material from the spectral information to the profile models to generate a fit score for each fit, wherein the lowest fit score corresponds to the best fit; calculating a mass value from the best fitting profile model and the sample profile. 1. A method for calculating a mass value of a material , comprising:determining an approximate mass value for an unknown material from spectral information derived from mass spectral analysis of the unknown material;retrieving a plurality of profile models that correspond to a known material from a data structure using the approximate mass value;fitting a sample profile for the unknown material from the spectral information to the profile models to generate a fit score for each fit, wherein the lowest fit score corresponds to the best fit;calculating a mass value from the best fitting profile model and the sample profile.2. The method of claim 1 , further comprising:determining the known material corresponding to the best fitting profile model.3. The method of claim 2 , further comprising:calculating a measure of abundance of the known material.4. The method of claim 3 , wherein:the measure of abundance is calculated by scaling the sample profile by an intensity correction factor.5. The method of claim 4 , wherein:the intensity correction factor relationship is calculated using an apex isotope intensity as a divisor of a dividend comprising the sample profile scaled to the apex isotope intensity.6. The method of claim 4 , wherein:the intensity correction factor relationship is calculated using a floating filter area of an isotope ...

Подробнее
Номер записи: 88
26-03-2020 дата публикации

Forced convection heater

Номер: US20200096230A1
Автор: Jason P. Pratt, Steven S. Black, Willis Watkins
Принадлежит: Rosemount Inc

A heating assembly includes a heater extending in a longitudinal direction from a first end to a second end. Heat transfer fins are thermally coupled to the heater and extend in a direction transverse to the longitudinal direction. An airflow component is positioned proximate one of the first and second end and is configured to generate airflow along the plurality of heat transfer fins toward the other of the first and second end.

Подробнее
Номер записи: 89
26-03-2020 дата публикации

Method for analyzing gas and device for analyzing gas

Номер: US20200096490A1
Автор: Atsuo Nakao, Kazuki Nagashima, Takeshi Yanagida, Yosuke Hanai
Принадлежит: Panasonic Corp

A method for analyzing a gas includes: allowing a sample gas to be adsorbed by each of a plurality of adsorbents ( 70 ) respectively having compositions that are different from each other; allowing the sample gas to be desorbed individually from the adsorbents ( 70 ) while detecting individually the sample gas desorbed from each of the adsorbents ( 70 ) so as to acquire desorption profiles of the sample gas that are respectively unique to the adsorbents ( 70 ); and identifying the sample gas by using a group of the desorption profiles. The acquiring of the desorption profiles is carried out by detecting, individually and over time, the sample gas desorbed from each of the adsorbents ( 70 ). Each of the desorption profiles is, for example, an overtime data created from a detection signal reflecting a quantity of the sample gas.

Подробнее
Номер записи: 90
21-04-2016 дата публикации

Adsorbent and Analysis Method Using Same

Номер: US20160109417A1
Автор: Ito Shinya, NAKANO Hiroshi, Nunoshige Jun
Принадлежит:

An adsorbent which enables solid phase extraction of water-soluble molecules with high efficiency and excellent selectivity and an analysis system using the adsorbent, the adsorbent containing a structure represented by the formula I 2. The adsorbent according to claim 1 , wherein R in the formula I is a carrier component comprising a resin.3. The adsorbent according to claim 1 , wherein in the formula I claim 1 , R′ is hydroxy group claim 1 , and R″ is independently selected from the group consisting of hydroxy group claim 1 , alkoxy group claim 1 , alkyl group and hydrogen atom.4. The adsorbent according to claim 1 , wherein in the formula I claim 1 , R′ is amino group claim 1 , and R″ is independently selected from the group consisting of hydroxy group claim 1 , alkoxy group claim 1 , alkyl group and hydrogen atom.5. The adsorbent according to claim 1 , wherein the color changes in response to an external stimulus.6. The adsorbent according to claim 1 , wherein the color changes by contact with a basic solution having a hydrogen ion exponent higher than 8.0.7. The adsorbent according to which is in the shape of a spherical or aggregated particle.8. The adsorbent according to which has a monolithic polymeric porous structure or a polymeric porous film structure.9. An analysis system having a solid phase extraction unit which comprises the adsorbent according to and in which a solute in a sample is selectively adsorbed to the adsorbent and an analyzer to which the solute desorbed from the adsorbent is introduced and in which the solute is analyzed.10. The analysis system according to claim 9 , wherein the analyzer is a liquid phase chromatography/ultraviolet spectrometer claim 9 , a mass spectrometer using liquid phase chromatography or a mass spectrometer of a flow injection analysis type.11. The analysis system according to claim 9 , wherein the sample comprises plasma claim 9 , serum claim 9 , blood claim 9 , urine claim 9 , a spinal fluid claim 9 , a synovial ...

Подробнее
Номер записи: 91
19-04-2018 дата публикации

PORTABLE WATER QUALITY INSTRUMENT

Номер: US20180106725A1
Автор: BENHABIB Merwan, Kleinman Samuel, Peterman Mark C.
Принадлежит:

A hand-held microfluidic testing device is provided that includes a housing having a cartridge receiving port, a cartridge for input to the cartridge receiving port having a sample input and a channel, where the channel includes a mixture of Raman-scattering nanoparticles and a calibration solution, where the calibration solution includes chemical compounds capable of interacting with a sample under test input to the cartridge and the Raman-scattering nanoparticles, and an optical detection system in the housing, where the optical detection system is capable of providing an illuminated electric field, where the illuminating electric field is capable of being used for Raman spectroscopy with the Raman-scattering nanoparticles and the calibration solution to analyze the sample under test input to the cartridge. 1. A portable testing device comprising ,a portable testing device housing, wherein said portable testing device housing comprises a cartridge receiving port;a cartridge for input to said cartridge receiving port, wherein said cartridge contains a mixture including a water sample comprising selenate, metallic Raman-scattering nanoparticles, and a selenate isotope or a sulfate isotope; andan optical detection system in said portable testing device housing, wherein said optical detection system is configured to provide an illuminating electric field, wherein said illuminating electric field is configured to produce Raman spectra of the selenate and isotope simultaneously while the cartridge is input to said cartridge receiving port to allow for a ratiometric analysis of the simultaneously produced selenate and isotope spectra to quantify the selenate in the water sample.2. The portable testing device of wherein said mixture further comprises an amine or thiol.3. The portable testing device of wherein said mixture further comprises an amine.4. A method for determining the concentration of selenate in a water sample comprising the steps of claim 1 ,adding metallic ...

Подробнее
Номер записи: 92
29-04-2021 дата публикации

LIQUID CHROMATOGRAPH INCLUDING PASSAGE SWITCH VALVE

Номер: US20210123892A1
Автор: SASANO Ryoichi
Принадлежит: AiSTI SCIENCE CO., Ltd.

A liquid chromatograph inc es: an analysis column; a sample loop that temporarily contains a mixed liquid of a sample and a mixture solvent; and a passage switch valve capable of switching a passage between a load position where the mixed liquid is temporarily held in the sample loop and an injection position where the mixed liquid held in the sample loop is sent to the analysis column. In the liquid chromatograph, a specific passage is formed in each of the load position and the injection position. 1. A liquid chromatograph comprising:a sample receiving part that receives a sample supplied by a sample supply pump;a mixture solvent supply pump for supplying a mixture solvent to be mixed with the sample at a predetermined mixture ratio;a sample loop that temporarily contains a mixed liquid of the sample and the mixture solvent, and has one end and an other end;an analysis column that performs separation on the sample into components;a detector that detects the components obtained by the separation in the analysis column;a mobile phase supply pump for sending a mobile phase to the analysis column; anda passage switch valve capable of switching a passage between a load position where the mixed liquid is temporarily held in the sample loop and an injection position where the mixed liquid held in the sample loop is sent to the analysis column, whereinthe passage switch valve has ports each of which is individually connected to: the sample receiving part; the mixture solvent supply pump; the one end and the other end of the sample loop; the analysis column; and the mobile phase supply pump,in the load position, passages a and b are formed, the passage a allowing communication between the ports respectively connected to the mixture solvent supply pump, the sample receiving part, and the one end of the sample loop, and the passage b allowing communication between the ports respectively connected to the mobile phase supply pump and the analysis column, and.in the injection ...

Подробнее
Номер записи: 93
02-04-2020 дата публикации

THERMAL GRADIENT CHROMATOGRAPHY DEVICES AND METHODS OF USING THEM

Номер: US20200103377A1
Автор: Lee Edgar D., Porter Nathan L., Waite Randall W.
Принадлежит:

Certain configurations described herein are directed to gas chromatography devices. In some instances, the gas chromatography devices may comprise at least one heating device which can be moved along a chromatography column to provide a thermal gradient to the chromatography column. In other instances, the gas chromatography devices may comprise a heating device that can receive a moving chromatography column to provide a thermal gradient to the chromatography column. The gas chromatography devices may be configured as portable devices which can be used to perform remote analyses. 1. A gas chromatography system comprising:a first heating device configured to thermally couple to a first section of a chromatography column in a first position of the first heating device and to thermally couple to a second section of a gas chromatography column in a second position of the first heating device, wherein the first heating device is configured to move longitudinally from the first position of the first heating device to the second position of the first heating device during a gas chromatographic separation; anda second heating device, separate from the first heating device, wherein the second heating device is configured to thermally couple to a first section of the gas chromatography column in a first position of the second heating device and to thermally couple to a second section of the gas chromatography column in a second position of the second heating device, wherein the second heating device is configured to move longitudinally from the first position of the second heating device to the second position of the second heating device during the chromatographic separation.2. The gas chromatography system of claim 1 , further comprising a respective motor coupled to each of the first heating device and the second heating device claim 1 , wherein the motor coupled to the first heating device is configured to move the first heating device from the first position of the ...

Подробнее
Номер записи: 94
02-04-2020 дата публикации

Chromatograph

Номер: US20200103382A1
Автор: Masahito Ito, Minling PEI, Shinichi Ozawa
Принадлежит: Hitachi High Tech Science Corp

To make it easy to address the case in which a chromatograph does not appropriately operate. A chromatograph (liquid chromatograph 100 ) for analyzing a sample by supplying an eluent and the sample and separating a component contained in the sample to detect the component, the chromatograph including: a detection portion (controller 170 ) configured to detect a fault in the analysis; and an operation controller (controller 170 ) configured to cause a constituent element related to the analysis to perform at least one of an operation for identifying a factor of the fault and an operation for avoiding the fault

Подробнее
Номер записи: 95
02-04-2020 дата публикации

Facilitation of canine detection of illegal substances in vehicles

Номер: US20200103384A1
Автор: Edward J. Maxwell, Luis E. Salinas
Принадлежит: Individual

A system includes a container to enclose vehicles within a chamber, an enclosed structure to house a canine to perform odor detection, and an air duct positioned therebetween. The container includes a first door, a second door, and a raised floor. The raised floor includes a first ramp leading to the first door, a second ramp leading to the second door, and sets of vent ducts defined between an outer wall and a top wall of the raised floor, the sets of vent ducts to direct air flow upwardly into the chamber of the container. The air duct includes a proximal end located proximate to an opening within the top wall of the container, a distal end fed through the enclosed structure to a canine-sniffing location, and one or more fan to pull air out of the chamber and deliver the air to the canine-sniffing location within the enclosed structure.

Подробнее
Номер записи: 96
02-04-2020 дата публикации

MEDICATION ADHERENCE MONITORING DEVICE

Номер: US20200103394A1
Автор: BATICH Chris, BAUMGARTNER Susan, BOOTH Matthew, Crumb Douglas, DENNIS Donn, KAUL Poonam, TANNER Mark, WASDO Scott, WOHLTJEN HANK
Принадлежит:

A Self Monitoring And Reporting Therapeutics SMART® composition, method, apparatus and system are provided which flexibly provide options, by combining different embodiments of the device with different embodiments of the composition, the ability to conduct definitive medication adherence monitoring over the short term (Acute Medication Adherence Monitoring, immediately up to an hour or so after taking a medication), intermediate term (Intermediate Medication Adherence Monitoring, IMAM, an hour or so to a day or so after taking a medication), and longer term (Chronic Medication Adherence Monitoring, CMAM, a day to several days after taking a medication). 1. A method for medication adherence monitoring in a subject who has been provided with a medication comprising a therapeutic agent and an isotopically-labelled exhaled drug ingestion marker (EDIM) or a taggant that generates the isotopically-labelled EDIM , said method comprising:(a) receiving exhaled breath of the subject into a mouthpiece of an adherence monitoring device, wherein the adherence monitoring device comprises the mouthpiece, a gas capture device, a catalytic incinerator, and a sensor for detecting isotopically-labeled compounds;(b) capturing the exhaled breath received from the mouthpiece by the gas capture device, wherein the gas capture device releasably captures volatile compounds from the exhaled breath;(c) incinerating the volatile compounds received by the catalytic incinerator from the gas capture device to form carbon dioxide, water, or both;(d) receiving the carbon dioxide, water, or both, by the sensor for detecting isotopically-labeled compounds, wherein the sensor detects the presence of isotopically-labeled carbon dioxide, isotopically-labeled water, or both; and(e) determining subject adherence in taking the medication based on an amount of isotopically-labeled carbon dioxide, isotopically-labeled water, or both, detected by the sensor.2. The method of claim 1 , wherein the medication ...

Подробнее
Номер записи: 97
11-04-2019 дата публикации

Optical flow cell assembly incorporating a replaceable transparent flow cell

Номер: US20190107487A1
Автор: Greenstreet Matthew, Rahmlow David, Sen Shiladitya
Принадлежит:

A new liquid flow cell assembly for light scattering measurements is disclosed which utilized a floating manifold system. The assembly operates with minimal stacked tolerances by aligning the cell to the windows within a manifold and independently aligning the cell to the read head directly. This configuration enables the ability to replace the flow cell or the flow cell/manifold assembly within a light scattering instrument without the need to realign the flow through elements with the light scattering illumination source while still maintaining reproducible, quality data. Some embodiments employ wide bore cells which enable the measurement of process analytic technology (PAT) including online monitoring of reactions. 1. An optical flow cell assembly comprising:a transparent flow cell;a manifold configured to contain the flow cell; a beam generating light source aligned to emit a beam of light along an axis of the read head;', 'and, 'a read head comprising'}wherein the read head is configured to be directly registered to the flow cell, thereby aligning the flow cell to the read head.2. The optical flow cell assembly of wherein the manifold comprises:a liquid sample inlet port; an inlet path coupled to an outlet of the inlet port;', 'an outlet path coupled to the inlet of the outlet port; and, 'a liquid sample outlet port;'}wherein the inlet path and the outlet path are configured to direct a flow of a liquid sample from the inlet port through the flow cell and out of the outlet port.3. The optical flow cell assembly of wherein the manifold further comprises transparent optical windows configured to allow the beam to pass into and out of the flow cell.4. The optical flow cell assembly of wherein the manifold further comprises a plurality of post elements incorporated into a surface of the manifold claim 2 , wherein the plurality of post elements is configured to contact the flow cell to determine a vertical registration of the flow cell relative to the manifold.5. ...

Подробнее
Номер записи: 98
11-04-2019 дата публикации

Vacuum liquid extraction and purification systems and methods

Номер: US20190107516A1
Автор: Caruso Joseph C., Hall Thomas G., Juma Rashid M., Shirkhan Hamid, Ten Broeck Dirk P., Yang Yijun
Принадлежит:

The invention features compact systems and methods for vacuum liquid purification and extraction of a liquid sample. 1. A vacuum system for purification of and extraction of at least one substance from a liquid sample comprising:a rotatable base for rotation between at least a first position and a second position;at least one assay column assembly having at least a first assay column and at least one second assay column;at least one Stage 1 solvent reservoir and having at least one easy connect fitting adapted for fluidic and reversible connection to the first assay column;at least one Stage 1 manifold mounted on a Stage 1 portion of the rotatable base and having at least one easy connect fitting adapted for fluidic and reversible connection with the second assay column;at least one Stage 2 reservoir and having at least one easy connect fitting adapted for fluidic and reversible connection with the second assay column;at least one Stage 2 manifold mounted on a Stage 2 portion of the rotatable base and having at least one easy connect fitting adapted for fluidic and reversible connection with the second assay column;wherein the first assay column has an easy connect fitting disposed at a first entry which is adapted for fluidic and reversible connection to the easy connect fitting of the Stage 1 solvent reservoir;wherein the first assay column has an easy connect fitting disposed at a first exit opposing the first entry of the first assay column which is adapted for fluidic and reversible connection to the second assay column;wherein the second assay column has an easy connect fitting disposed at a first entry of the second assay column which is adapted for fluidic and reversible selective alternate connection with the first assay column and the Stage 2 manifold;wherein the second assay column has an easy connect fitting disposed at a first exit opposing the first entry of the first assay column which adapted for fluidic and reversible selective alternate connection ...

Подробнее
Номер записи: 99
11-04-2019 дата публикации

REFILLING-TYPE ONLINE CHROMATOGRAPHIC DETECTOR FOR SULPHUR HEXAFLUORIDE DECOMPOSITION PRODUCTS

Номер: US20190107517A1
Автор: FAN Xiaopeng, HUANG Chengji, Li Li, LI Xiaodian, LIU Jiawen, TANG Nian, WU Peiqi, ZHOU Yongyan
Принадлежит: ELECTRIC POWER RESEARCH INSTITUTE OF GUANGDONG POWER GRID CO., LTD.

A backfilling-type online chromatographic detector for sulphur hexafluoride decomposition products includes: a compression pump, a vacuum pump, a gas storage tank, a first six-way valve, a second six-way valve, a first chromatographic column, a second chromatographic column and a detector. One end of the compression pump is connected to one end of the vacuum pump, another end of the vacuum pump is connected to one end of the gas storage tank, another end of the gas storage tank is connected to the first chromatographic column through the first six-way valve, the first chromatographic column is connected to the second chromatographic column through the second six-way valve, and the second chromatographic column is connected to the detector. 1. A backfilling-type online chromatographic detector for sulphur hexafluoride decomposition products , comprising: a compression pump , a vacuum pump , a gas storage tank , a first six-way valve , a second six-way valve , a first chromatographic column , a second chromatographic column and a detector , whereinone end of the compression pump is connected to one end of the vacuum pump,another end of the vacuum pump is connected to one end of the gas storage tank,another end of the gas storage tank is connected to the first chromatographic column through the first six-way valve,the first chromatographic column is connected to the second chromatographic column through the second six-way valve, andthe second chromatographic column is connected to the detector.2. The backfilling-type online chromatographic detector for sulphur hexafluoride decomposition products according to claim 1 , further comprising: a sample loop claim 1 , whereina sample inlet end of the sample loop is connected to a sixth port of the first six-way valve, and a sample outlet end of the sample loop is connected to a third port of the first six-way valve.3. The backfilling-type online chromatographic detector for sulphur hexafluoride decomposition products ...

Подробнее
Номер записи: 100