Compositions

Manufactoring process of a biodegradable film hydophobe and transparency and film thus obtained

VERFAHREN ZUR HERSTELLUNG EINES SCHAUMSTOFFES

VERFAHREN ZUR HERSTELLUNG EINES SCHAUMSTOFFES

PROCEDURE FOR THE PRODUCTION OF A HYDROPHOBEN TRANSPARENT ONE AND BIOLOGICAL DEGRADABLE FILM AND SO RECEIVED FILM

COMPOSITION FOR THE PRODUCTION OF A AT LEAST PARTIAL BIOLOGICAL DEGRADABLE FOIL AS WELL AS SUCH A FOIL

Highly efficacious hemostatic adhesive polymer scaffold

The invention relates to biocompatible polymer gel compositions useful in facilitating and maintaining hemostasis. The biocompatible polymeric gel composition is comprised of (a) one or more than one polyanionic polymer, (b) one or more than one polycationic polymer, and (c) a solvent. A preferred composition includes sodium alginate, chitosan, and water to produce an adhesive hemostatic device that is useful in facilitating and maintaining rapid hemostasis.

HIGHLY EFFICACIOUS HEMOSTATIC ADHESIVE POLYMER SCAFFOLD

The invention relates to biocompatible polymer gel compositions useful in facilitating and maintaining hemostasis. The biocompatible polymeric gel composition is comprised of (a) one or more than one polyanionic polymer, (b) one or more than one polycationic polymer, and (c) a solvent. A preferred composition includes sodium alginate, chitosan, and water to produce an adhesive hemostatic device that is useful in facilitating and maintaining rapid hemostasis.

METHOD FOR PREPARING POROUS SCAFFOLD FOR TISSUE ENGINEERING, CELL CULTURE AND CELL DELIVERY

The present invention relates to a method for preparing a porous scaffold for tissue engineering. It is another object of the present invention to provide a porous scaffold obtainable by the method as above described, and its use for tissue engineering, cell culture and cell delivery. The method of the invention comprises the steps consisting of: a) preparing an alkaline aqueous solution comprising an amount of at least one polysaccharide, an amount of a cross-linking agent and an amount of a porogen agent b) transforming the solution into a hydrogel by placing said solution at a temperature from about 4°C to about 80°C for a sufficient time to allow the cross-linking of said amount of polysaccharide and c) submerging said hydrogel into an aqueous solution d) washing the porous scaffold obtained at step c).

High-amylose sodium carboxymethyl starch sustained release excipient and process for preparing the same

A process for obtaining a spray-dried high amylose sodium carboxymethyl starch comprising a major fraction of amorphous form and optionally a minor fraction of crystalline V form, is provided. The process comprises providing an amorphous pregelatinized high amylose sodium carboxymethyl starch (HASCA); dispersing the amorphous pregelatinized HASCA in a solution comprising water and at least one first pharmaceutically acceptable organic solvent miscible with water and suitable for spray-drying; and spray-drying the dispersion to obtain the spray-dried HASCA comprising a major fraction of amorphous form and optionally a minor fraction of crystalline V form, in the form of a powder. Also provided is a spray-dried HASCA sustained-release excipient. This excipient is useful for preparing a tablet for the sustained-release of at least one drug.

Microcrystalline cewllulose compositions

公开了超细微晶纤维素，该组合物包含共磨碎微晶纤维素和水溶胶。组合物的平均粒径小于10微米。组合物的制备方法是：在抗滑剂，最好是无机盐水溶液存在的情况下对高固体含量的微晶纤维素与水溶胶所组成的混合物施加高剪切力。组合物特别适用于食品、医药、化妆品和工业领域。

METHOD FOR PREPARING A POROUS LAYER

La présente invention se rapporte à un procédé de préparation d'une couche poreuse de polymère biocompatible, présentant une densité et une porosité homogènes, comprenant les étapes suivantes : - a) une quantité Qp de solution dudit polymère, présentant une viscosité Vp, est versée dans un moule afin de former une première sous-couche , la surface de la première sous-couche étant laissée à l'air libre, - b) une quantité Qs de solvant, présentant une viscosité Vs inférieure à Vp, est répartie uniformément sur la surface de la première sous-couche afin de former une deuxième sous-couche, c) la première et la deuxième sous-couches sont soumises à une étape de lyophilisation.

SELF-FOAMING ACIDIC COMPOSITION AND PROCESS FOR THE PREPARATION THEREOF

Une composition auto-moussante en milieu acide comprenant : - au moins un polymère hydrophile, - au moins un composé capable de réticuler le polymère hydrophile par la formation de liaisons ioniques, - au moins un agent moussant, et - au moins un agent stabilisant des mousses, et son utilisation comme médicament, notamment pour la prévention et/ou le traitement de l'obésité. A self-foaming composition in an acid medium comprising: - at least one hydrophilic polymer, - at least one compound capable of crosslinking the hydrophilic polymer by the formation of ionic bonds, - at least one foaming agent, and - at least one stabilizing agent for foams, and its use as a medicament, in particular for the prevention and / or treatment of obesity.

MICROALGAE CULTURE SYSTEM CONTAINING ALGINATE FILM AND OPTICAL FIBER, AND PRODUCTION METHOD THEREOF

The present invention relates to a microalgae culture system which comprises: at least one culture layer including a microalgae-containing alginate film; and at least one light source layer laminated on at least one side of the culture layer and containing optical fiber. More specifically, provided is a spatially integrated microalgae culture system which stands strong against contamination and improves productivity of microalgae through uniform light emission, by coupling optical fiber onto a surface of a microalgae-containing alginate film. Moreover, provided is a photobiologic reactor including the same. COPYRIGHT KIPO 2017 (AA) Alginate film (BB) Optical fabric (CC) Hygroscopic membrane ...

Hydrogel membrane for adhesion prevention

A biocompatible membrane comprised of alginate and hyaluronate. The membrane may be used to prevent unwanted scarring after surgery. The tissue adherence and the rate of bioresorption of the membrane may be modified through an external stimulus comprising a sequestering agent and a viscosity modifier.

COMPOSITIONS AND METHODS FOR DELIVERY OF ACTIVE AGENTS

The present disclosure relates to remediation of contaminated environmental sites. In particular, the present disclosure relates to passive control compositions and their use in remediation. 1. A composition , comprising:an inactive hydrogel with a core of an active agent surrounded by a polymer shell, wherein said polymer swells and releases said agent in response to a change in environment.2. The composition of claim 1 , wherein said polymer is selected from the group consisting of chitosan claim 1 , carboxymethylcellulose claim 1 , alginate claim 1 , polyacrylamide claim 1 , and carrageenan.3. The composition of or claim 1 , wherein said polymer is cross-linked.4. The composition of claim 3 , wherein said polymer is cross-linked with a cross-linking agent selected from the group consisting of glutaraldehyde claim 3 , formaldehyde claim 3 , and genipin.5. The composition of claim 1 , wherein said active agent is selected from the group consisting of calcium carbonate claim 1 , magnesium oxide claim 1 , and citric acid.6. The composition of claim 1 , wherein said active agent is a nanoparticle claim 1 , a micron sized particle claim 1 , or a droplet.7. The composition of claim 1 , wherein said change in environment is selected from the group consisting of pH claim 1 , temperature claim 1 , and oxidation state.8. The composition of claim 1 , wherein release of said agent alters the pH of said environment.9. The composition of claim 1 , wherein said inactive hydrogel is dehydrated or in a colloidal suspension.10. A method of remediating an environmental site claim 1 , comprising:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'introducing the composition of to an environmental site undergoing remediation under conditions such that said composition releases said active agent only within a defined pH range.'}11. The method of claim 10 , wherein said defined pH range is determined by the polymer and crosslinking agent.12. The method of claim 10 , wherein said ...

SOFT GOODS FORMED FROM A FIBER LIQUID SLURRY HAVING SURFACE FEATURES, AND METHODS FOR MAKING THE SAME

The present invention discloses a molded article having a surface feature created by a light reactive agent interacting with light from a light source, and a method for making the same. The article is molded from a slurry comprised of an aqueous solution that includes a plurality of fibers and a light reactive agent. The slurry is molded into a three-dimensional solid fibrous molded part. The solid fibrous molded part is exposed to a light source such that the light reacts with the light reactive agent to create at least one surface feature. The surface feature can be, for example, a texture or a color change.

Method for producing alginate-containing porous mouldings

Die Erfindung betrifft Verfahren zur Herstellung von Alginathaltigen porösen bzw. schwammartigen Formkörpern, sowie die danach erhältlichen Formkörper und deren Verwendung, ...

СЪЕДОБНОЕ ФОРМОВОЧНОЕ ИЗДЕЛИЕ В ВИДЕ ПЛОСКОЙ ИЛИ РУКАВНОЙ ПЛЕНКИ

FIELD: food-processing industry. SUBSTANCE: method involves mixing biopolymers, decomposition products thereof or derived and/or synthetic polymers with at least one edible plasticizer, at least one softener and at least one cross-linking agent; melting resultant mixture into thermoplastic mass; extruding said mass and calendaring and/or drawing or providing pneumatic molding of extruded product to produce edible formed body, which is suitable for packing of food products, such as sausage and cooked ham. Such bodies are suitable, in particular, as seamless casing for sausage products. EFFECT: provision for producing of ecologically safe casing, reduced production costs and simplified method. 15 cl, 3 tbl сч9Ессс ПЧ сэ (19) РОССИЙСКОЕ — АГЕНТСТВО ПО ПАТЕНТАМ И ТОВАРНЫМ ЗНАКАМ КО (51) МПК? (11) (13) 2 223 653 А 22 С 13/00 С2 12 ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ РОССИЙСКОЙ ФЕДЕРАЦИИ (21), (22) Заявка: 99119098/12 , 19.12.1997 (24) Дата начала действия патента: 19.12.1997 (30) Приоритет: 07.02.1997 ОЕ — 19704737.8 (43) Дата публикации заявки: 27.03.2002 (46) Дата публикации: 20.02.2004 (56) Ссылки: ЕР 0709030 А, 01.05.1996. ОЕ 4309528 А, 29.09.1994. ОЕ 2411587 В2, 30.12.1976. $Ч 1785419 А, 30.12.1992. (85) Дата перевода заявки РСТ на национальную фазу: 07.09.1999 (86) Заявка РСТ: ЕР 97/07212 (19.12.1997) (87) Публикация РСТ: У\УУ/о 98/34490 (13.08.1998) (98) Адрес для переписки: 129010, Москва, ул. Б. Спасская, 25, стр.3, ООО "Юридическая фирма Городисский и Партнеры", пат.пов. Н.Г.Лебедевой (72) Изобретатель: ХАММЕР Клаус-Дитер (ОЕ), ГРОЛИГ Герхард (0Е), АЛЕРС — Михель (ОЕ), ДЕЛИУС Ульрих (0Е) (73) Патентообладатель: КАЛЛЕ НАЛО ГМБХ УНД КО. КГ (ОЕ) (74) Патентный поверенный: Лебедева Наталья Георгиевна (54) СЪЕДОБНОЕ ФОРМОВОЧНОЕ ИЗДЕЛИЕ В ВИДЕ ПЛОСКОЙ ИЛИ РУКАВНОЙ ПЛЕНКИ (57) Изобретение относится к съедобному формовочному изделию в виде плоской или рукавной пленки на основе пластифицируемых биополимеров, продуктов их расщепления или производных и/или синтетических ...

ESSBARE FORMKÖRPER, INSBESONDERE FLACH- UND SCHLAUCHFOLIEN

Wellbore servicing fluid compositions and use thereof

Alginate monomer structure with metal crystallite embedded, alginate salt structure with metal crystallite embedded and method of producing alginate hydrogel

Polymer compositions

COMPOSITIONS OF SEMI-INTERPENETRATING POLYMER NETWORK

Novel compositions consisting of semi-interpenetrating network of cross-linked water soluble derivatives of basic polysaccharides and a non-cross-linked component, which is an anionic polysaccharide are provided. Methods for the production of such compositions are also disclosed. Preferably the basic polysaccharide is chitosan or a derivative thereof and the anionic polysaccharide is hyaluronic acid. The compositions can be formed into gels or films, for example, and thus find use in a wide range of medical applications in the fields of dermatology, plastic surgery, urology and orthopaedics.

MAGNETIC POLYMER PELLETS AND THEIR APPLICATION METHODS

The invention is related to polymer pellets and the methods of their application for controlled release of active substances into the application environment, for example, substances for the initiation, acceleration or inhibition of physico-chemical processes like gellation, cementation etc. As per the invention, the polymer pellet is a gel matrix of an anionic polymer cross-linked with multivalent metals' cations in which at least one active substance and ferromagnetic particles are dispersed with the concentration of ferromagnetic micro-particles from 0.5 to 5%. As per this invention, the polymer pellets may be used for the controlled release of the active substance into the application medium, for obtaining polymer gels and for the generation of locking gel plugs.

HYDROGEL MEMBRANE FOR ADHESION PREVENTION

A biocompatible membrane comprised of alginate and hyaluronate. The membrane may be used to prevent unwanted scarring after surgery. The tissue adherence and the rate of bioresorption of the membrane may be modified through an external stimulus comprising a sequestering agent and a viscosity modifier.

METHOD OF PRODUCING POLYSACCHARIDE FOAMS

Disclosed is a method of producing polysaccharide foams and foams produced by the method. The polysaccharide foams are formed from a wet condition and are convection dried with a flow of warm or hot air. Such foams exhibit improvements over foams dried under ambient conditions. The present invention also discloses the formation of multi-ply foam layers. At least two sheets of foam layers are layered together and laminated either mechanically or chemically to produce a composite structure.

Edible film based on crosslinking modification of Sanzan gum as well as preparation method and application of edible film

Preparation method of hydrogel blended film embedded with quorum sensing inhibitor

Method for producing a high-percolating adsorbent membrane

Procédé de fabrication d’une membrane adsorbante à haut pouvoir de percolation L’invention concerne un procédé de fabrication d’une membrane adsorbante (1) qui comprend les étapes suivantes : a) on prépare un mélange qui contient au moins : - une solution aqueuse de polymère cationique dont le pH est compris entre 5 et 8; - une solution aqueuse de polymère anionique ; b) on agite le mélange ; c) on laisse maturer le mélange jusqu’à l’obtention au sein du mélange d’une membrane sous la forme d’un hydrogel ; d) on ajoute au moins un agent de réticulation de manière à réticuler la membrane ;e) on sèche la membrane réticulée obtenue à l’issue de l’étape d). L’invention concerne aussi l’utilisation de cette membrane (1) pour le traitement d’effluents liquides ou gazeux, ainsi qu’en tant que support anti-microbiens ou pour la catalyse hétérogène. Figure 2 Process for manufacturing an adsorbent membrane with high percolation power The invention relates to a process for manufacturing an adsorbent membrane (1) which comprises the following steps: a) a mixture is prepared which contains at least: - an aqueous solution of cationic polymer whose pH is between 5 and 8; - an aqueous solution of anionic polymer; b) the mixture is stirred; c) the mixture is allowed to mature until it obtains within the mixture a membrane in the form of a hydrogel; d) at least one crosslinking agent is added so as to crosslink the membrane; e) the crosslinked membrane obtained at the end of step d) is dried. The invention also relates to the use of this membrane (1) for the treatment of liquid or gaseous effluents, as well as as an anti-microbial support or for heterogeneous catalysis. Figure 2

HYBRID BIOCOMPOSITE S2P

METHOD FOR PREPARING POROUS SCAFFOLD FOR TISSUE ENGINEERING, CELL CULTURE AND CELL DELIVERY

... 27METHOD FOR PREPARING POROUS SCAFFOLD FOR TISSUE ENGINEERING, CELL CULTURE AND CELL DELIVERYAbstractThe present invention relates to a method for preparing a porous scaffold for tissue engineering. It is another object of the present invention to provide a porous scaffold obtainable by the method as above described, and its use for tissue engineering, cell culture and cell delivery. The method of the invention10 comprises the steps consisting of: a) preparing an alkaline aqueous solution comprising an amount of at least one polysaccharide, an amount of a cross-linking agent and an amount of a porogen agent b) transforming the solution into a hydrogel by placing said solution at a temperature from about 4°C to about 80°C for a sufficient time to allow the cross-linking of said amount of15 polysaccharide and c) submerging said hydrogel into an aqueous solution d) washing the porous scaffold obtained at step c).(no suitable figure) ...

IONIC GEL

A process for the formation of an ionic gel comprising contacting a first polyelectrolyte reactant having a backbone comprising a plurality of -1,4-glycosidic linkages in the 4C1 conformation and an oligoelectrolyte reactant or second polyelectrolyte reactant, having a backbone containing a plurality of -1,4-glycosidic linkages in the 4C1 conformation, in aqueous solution under pH conditions such that one reactant is charged and the other uncharged; adding a donor to adjust the pH such that said uncharged reactant possesses a charge opposite to that of the charged reactant so as to form an ionic gel.

ВЫСОКОЭФФЕКТИВНЫЙ ГЕМОСТАТИЧЕСКИЙ АДГЕЗИВНЫЙ ПОЛИМЕРНЫЙ КАРКАС

Группа изобретений раскрывает полимерную композицию для облегчения и поддержания гемостаза и способ получения указанной композиции. Композиция характеризуется тем, что содержит от 1 до 5% масс. альгината натрия, от 5 до 40% масс. хитозана и от 50 до 94% масс. воды, где полимерная композиция представляет собой коллоидный гель с твердыми частицами хитозана, диспергированными в растворе альгината натрия в воде. Способ включает в себя смешивание альгината натрия с водой и дальнейшее добавление хитозана с получением полимерной композиции. Твердые частицы геля позволяют механически предотвращать протекание текучей среды через гель, а также улучшают адгезию/агрегацию клеток, обеспечивая эффективость в облегчении и поддержании гемостаза. 4 н. и 12 з.п. ф-лы, 1 пр., 3 ил.

ВЫСОКОЭФФЕКТИВНЫЙ ГЕМОСТАТИЧЕСКИЙ АДГЕЗИВНЫЙ ПОЛИМЕРНЫЙ КАРКАС

Eßbare Formkörper, insbesondere Flach- und Schlauchfolien

The invention relates to edible molded bodies in the form of a flat or tubular film based on plastifiable biopolymers, the cleavage products or derivatives thereof and/or synthetic polymers from natural monomers, characterized in that they are produced according to a method comprising the following steps: a) the biopolymers, cleavage products or derivatives thereof and/or synthetic polymers are mixed with at least one edible plasticizer, at least one lubricating agent and at least one cross-linking agent, b) the mixture thus obtained is melted into a thermoplastic material, c) said material is extruded and d) the product obtained by extrusion is calendered and/or stretched or blown and deformed into the edible molded body. The molded bodies cited in the invention are suitable for use as food wrappers for sausages and boiled ham, and are particularly suitable for use as seamless sausage casings.

Polymer compositions

BIOCOMPOSITE MATERIAL COMPRISING CNF AND AN ANIONIC GELLING POLYSACCHARIDE

A composite material comprising 65-99wt% cellulose nanofibers and 0.5-30 wt% of an anionic gelling polysaccharide,as calculated by dry weight of the composite material,a method for preparing such composite material,and different applications and usesof the composite material.

HYDROGELS BASED ON FUNCTIONALIZED POLYSACCHARIDES

The present invention relates to functionalized hydrogel networks grafted with at least one moiety for use in numerous fields, from cosmetics to surgery and medicine.

POLYMER BINDERS FOR SILICON OR SILICON-GRAPHITE COMPOSITE ELECTRODES AND THEIR USE IN ELECTROCHEMICAL CELLS

Described are polymers, polymer binders, hydrogel polymer binders, hydrogel polymer binder compositions comprising them, electrode materials comprising them, their methods of production and their use in electrochemical cells, for instance, in silicon-based electrochemical cells.

FILM-FORMING COMPOSITION FOR USE IN PREPARATION OF A BIODEGRADABLE FILM ESSENTIALLY.

PROCESS FOR THE PREPARATION OF A FLEXIBLE FILM OF CALCIUM ALGINATE

METHOD FOR PREPARING POROUS SCAFFOLD FOR TISSUE ENGINEERING, CELL CULTURE AND CELL DELIVERY

The present invention relates to a method for preparing a porous scaffold for tissue engineering. It is another object of the present invention to provide a porous scaffold obtainable by the method as above described, and its use for tissue engineering, cell culture and cell delivery. The method of the invention comprises the steps consisting of: a) preparing an alkaline aqueous solution comprising an amount of at least one polysaccharide, an amount of a cross-linking agent and an amount of a porogen agent b) transforming the solution into a hydrogel by placing said solution at a temperature from about 4°C to about 80°C for a sufficient time to allow the cross-linking of said amount of polysaccharide and c) submerging said hydrogel into an aqueous solution d) washing the porous scaffold obtained at step c). COPYRIGHT KIPO & WIPO 2010 ...

MICROCRYSTALLINE CEWLLULOSE COMPOSITIONS

Ultra-fine microcrystalline cellulose compositions are disclosed which comprise co-attrited microcrystalline cellulose and a hydrocolloid. The compositions have a mean particle size of less than 10 microns. The compositions are prepared by subjecting a high solids mixture of microcrystalline cellulose and a hydrocolloid to high shear forces in the presence of an anti slip agent preferably an aqueoussolution of an inorganic salt. The compositions are especially useful in food, pharmaceutical and cosmetic and industrial appications.

METHODS OF MANUFACTURING CORE-SHELL MICROPARTICLES, AND MICROPARTICLES FORMED THEREOF

Methods of manufacturing core-shell microparticles having a core comprising a hydrogel material and a shell comprising a hydrophobic polymer immiscible with the hydrogel material are presented. Core-shell microparticles having a core comprising a hydrogel material and a shell comprising a hydrophobic polymer immiscible with the hydrogel material, as well as core-shell microparticles manufactured using the methods, and pharmaceutical compositions comprising the core-shell microparticles are also presented.

Sound absorbing article, method of producing the same, and method of recycling the same

A sound absorbing article has a water-soluble foamed matrix including a water-soluble polymer and an ionic surfactant, in which an open cell is formed in the foamed matrix.

DELAYED ONSET CALCIUM ALGINATE GELS AND METHOD OF PRODUCTION

A method of producing a gel comprises combining an acidic aqueous alginate solution with a second, less acidic aqueous suspension of a calcium salt. A product comprises an alginate-based air treatment gel that is not subject to temperature-induced liquefaction. 1. A method of producing a gel , comprising combining an acidic aqueous alginate solution with a second , less acidic aqueous suspension of a calcium salt.2. The method of wherein the acidic aqueous alginate solution has a pH between 4 and 5.3. The method of claim 1 , wherein the suspension of calcium salt has a pH between 5 and 8.4. The method of claim 1 , wherein the combined solution and suspension has a pH between 4 and 6 immediately after mixing.5. The method of claim 1 , wherein the calcium salt is at least 10 times more soluble at the pH immediately after mixing than in the aqueous suspension.6. The method of claim 1 , wherein the acidic aqueous alginate solution comprises an acidic pH modifier claim 1 , preferably selected from the group consisting of acetic acid claim 1 , citric acid claim 1 , phosphoric acid claim 1 , hydrochloric acid claim 1 , sulfuric acid claim 1 , and lactic acid claim 1 , malic acid claim 1 , and combinations thereof.7. The method of claim 1 , wherein the calcium salt suspension further comprises a suspending agent claim 1 , preferably selected from the group consisting of acacia gums claim 1 , agar claim 1 , acrylic acid claim 1 , albumins claim 1 , carrageenans claim 1 , carbopols claim 1 , casein claim 1 , cellulose gums claim 1 , chitosan claim 1 , chondroitin claim 1 , curdlan claim 1 , gelatin claim 1 , dextran claim 1 , fibrin claim 1 , fulcelleran claim 1 , gellan gum claim 1 , ghatti gum claim 1 , guar gum claim 1 , gum tragacanth claim 1 , heparin claim 1 , hyaluronic acid claim 1 , karaya gum claim 1 , locust bean gum claim 1 , pea protein claim 1 , pectin claim 1 , polyoxyethylene-polyoxypropylene and other synthetic block copolymers claim 1 , pullulan claim 1 , ...

HYDROGEL MEMBRANE FOR ADHESION PREVENTION

The invention provides a kit including a hydrogel composition comprising: uncrosslinked hyaluronate; crosslinked alginate and un-crosslinked alginate; a crosslinker comprising a cation configured to crosslink the un-crosslinked alginate; and a chelator configured to chelate the cation; wherein the un-crosslinked alginate includes sodium alginate and the crosslinker includes calcium; and a syringe.

СПОСОБ ПОЛУЧЕНИЯ ПОРИСТЫХ МАТЕРИАЛОВ ИЗ АЛЬГИНАТА НАТРИЯ И ПОЛИВИНИЛПИРРОЛИДОНА, СОДЕРЖАЩИХ ФОСФАТЫ КАЛЬЦИЯ

Изобретение может быть использовано в реконструктивно-пластической хирургии для пластической реконструкции поврежденных костных тканей. Для получения пористых материалов из альгината натрия и поливинилпирролидона, содержащих фосфаты кальция, для заполнения костных дефектов проводят синтез in situ фосфатов кальция в 2% водном растворе поливинилпирролидона при температуре реакционной смеси от 37 до 90°С. После завершения синтеза фосфатов кальция в реакционную смесь добавляют 2% водный раствор альгината натрия, перемешивают в течение 30 мин. Реакционную смесь вспенивают пропусканием через нее воздуха с использованием компрессора. Вспененную массу обрабатывают 5% водным раствором комплексного соединения железа (3+) с салициловой кислотой, замораживают в морозильной камере при температуре от -10 до -18°С и высушивают в лиофильной сушилке. Изобретение позволяет получить высокопористый биосовместимый материал, включающий равномерно распределенные наноразмерные частицы фосфатов кальция, приближенный ...

Verfahren zur Herstellung von Alginat-haltigen porösen Formkörpern

Die Erfindung betrifft ein Verfahren zur Herstellung von Alginat-haltigen porösen bzw. schwammartigen Formkörpern sowie die danach erhältlichen Formkörper und deren Verwendung.

EDIBLE MOLDED ARTICLES, IN PARTICULAR FLAT AND SCHLAUCHFOLIEN

PROCEDURE FOR THE PRODUCTION OF A FOAM MATERIAL

PROCEDURE FOR THE PRODUCTION OF A FOAM MATERIAL

A kind of multi-functional preservation film for meat products and its application

The present invention discloses a multi-functional preservation film for meat products, which is prepared by using nanofiber film as the substrate and acidic polysaccharide-based ovalbumin loaded on the surface, and its preparation method is to obtain nanofiber film by using sodium alginate, carboxymethyl chitosan, polyethylene glycol, nano bamboo fiber, bamboo leaf flavonoid, curcumin, poly lysine and calcium gluconate as raw materials by electrostatic spinning technology, and then using layer self assembly technology to The nano-fiber membrane is obtained by loading acidic polysaccharide-based ovalbumin onto the nano-fiber membrane; it can maintain the effective active ingredients in the membrane and release the active ingredients slowly, which prolongs the shelf life of the membrane; the membrane is yellow in color, which has good antiseptic and antioxidant properties and is used for preserving meat products, which prolongs the shelf life of meat products; at the same time, it has the ...

Edible molded bodies, especially flat and flexible tubular films

PROCEDE DE PREPARATION D'UN FILM SOUPLE D'ALGINATE DE CALCIUM

La présente invention concerne un procédé de préparation d'un film souple d'alginate de calcium. Selon l'invention, on mélange une solution d'alginate de sodium avec une solution de chlorure de calcium sous agitation contrôlée, en présence d'un gaz inerte, on élimine le chlorure de sodium formé, on congèle rapidement l'émulsion produite, puis on lyophilise l'émulsion.

HIGH-AMYLOSE SODIUM CARBOXYMETHYL STARCH SUSTAINED RELEASE EXCIPIENT AND PROCESS FOR PREPARING THE SAME

A process for obtaining a spray-dried high amylose sodium carboxymethyl s tarch comprising a major fraction of amorphous form and optionally a minor f raction of crystalline V form, is provided. The process comprises providing an amorphous pregelatinized high amylose sodium carboxymethyl starch (HASCA) ; dispersing the amorphous pregelatinized HASCA in a solution comprising wat er and at least one first pharmaceutically acceptable organic solvent miscib le with water and suitable for spray-drying; and spray-drying the dispersion to obtain the spray-dried HASCA comprising a major fraction of amorphous fo rm and optionally a minor fraction of crystalline V form, in the form of a p owder. Also provided is a spray-dried HASCA sustained-release excipient. Thi s excipient is useful for preparing a tablet for the sustained-release of at least one drug.

GELLED FOAMS GELLED FOAMS

... 1693H/2098a K2120 TITLE OF THE INVENTION GELLED FOAMS Stable gel foam compositions which include a gellable polysaccharide such as alginate, xanthan gum, welan gum, or rhamsan gum, a polyvalent ionic complexing agent, a surface active foaming agent such as synthetic or natural organic compounds, and water.

ALGINATE GEL BASED ADSORBENTS FOR HEAVY METAL REMOVAL

An alginate gel adsorbent to remove heavy metal ions according to the present invention is prepared by adding dropwisely 0.1-5 wt % alginate solution to a polyvalent cationic solution thereby cross-linking alginic acid with polyvalent cations. An alginate gel adsorbent containing activated carbon capable of simultaneously removing heavy metal ions and organotoxic materials, that is, activated carbon/alginate gel adsorbent, is prepared by adding dropwisely a mixed solution of 0.1-10 wt % of alginate and 0.1 10 wt % of activated carbon powder to a polyvalent cationic solution thereby cross-linking alginic acid with polyvalent cations in order to immobilize polyvalent cation to alginic acid containing activated carbon. The polyvalent cationic solution is selected from the group consisting of calcium chloride (CaCl2), strontium chloride (SrCl2), barium chloride (BaCl2) and aluminium chloride (AlCl3). A flat board or a thin membrane coated alginate gel adsorbent can be prepared by coating alginate ...

Preparation method of calcium alginate electrically-driven film adopting microwave vacuum low-temperature drying technology

BIO-HYBRID COMPOSITE S2P

Matériau bio-composite, éco-conçu, destiné à de multiples applications dans les domaines du Bâtiment principalement et des Transports, constitué de renforts d'origine bio-sourcée exclusivement végétale, caractérisé par son mélange de fibres végétales très largement majoritaires entre 90% à 100% du composite, entre fibres brutes et sous-produits de l'agriculture avec des fibres végétales recyclées, et un liant écologique comprenant des polysaccharides, dans la proportion de 5 à 10% en masse du bio-composite.

PROCESS FOR THE PREPARATION OF BIOCOMPATIBLE POLYMERS AND BIODEGRADABLE POROUS MATRICES TRIMENSIONNELLES AND APPLICATIONS

IONIC GEL

A process for the formation of an ionic gel comprising contacting a first polyelectrolyte reactant having a backbone comprising a plurality of β-1,4-glycosidic linkages in the4C1 conformation and an oligoelectrolyte reactant or second polyelectrolyte reactant, having a backbone containing a plurality of β-1,4-glycosidic linkages in the4C1 conformation, in aqueous solution under pH conditions such that one reactant is charged and the other uncharged; adding a donor to adjust the pH such that said uncharged reactant possesses a charge opposite to that of the charged reactant so as to form an ionic gel.

ALGINATE COATED, POLYSACCHARIDE GEL-CONTAINING FOAM COMPOSITE, PREPARATIVE METHODS, AND USES THEREOF

The invention relates to composites comprising a polysaccharide gelled within pores of a foam and an polysaccharide coating, methods of preparation, and uses thereof, for example, in biomedical applications such as cell culture media and implants, controlled release delivery systems, food applications, industrial applications, and personal care applications such as cosmetic and oral hygiene.

Shear-thinning hydrogel, kit and method of preparation

A shear-thinning hydrogel composition includes: a first polymer chain including: (i) a first plurality of units each having at least one of a monosaccharide and an amino acid; and (ii) a cross-linking group bound to the at least one of the monosaccharide and the amino acid of one of the first plurality of units via conversion of a carboxyl group of the unit to a peptide bond; a second polymer chain including a second plurality of the units; and a cross-linking additive connecting one of the second plurality of units to the first polymer chain via the cross-linking group.

Gelled foams

Stable gel foam compositions which include a gellable polysaccharide such as alginate, xanthan gum, welan gum, or rhamsan gum, a polyvalent ionic complexing agent, a surface active foaming agent such as synthetic or natural organic compounds, and water.

METHOD OF ENCAPSULATING POLYMER ADDITIVES

High-amylose sodium carboxymethyl starch sustained release excipient and process for preparing the same

HYDROGEL COMPOSITION FOR A SEMI-RIGID ACOUSTIC COUPLING MEDIUM IN ULTRASOUND IMAGING

Disclosed are compositions and articles for a semi-rigid hydrogel material that provides an acoustic coupling medium for ultrasound diagnostic and treatment techniques. In one aspect, a hydrogel material for an acoustic coupling medium includes a sodium alginate block copolymer, a dimethylacrylamide monomer, and water. In some implementations, the sodium alginate block copolymer is present in an amount of about 0.5 wt% to about 25 wt%, the dimethylacrylamide monomer is present in an amount of about 1 wt% to about 40 wt%, and the water is present in an amount of at least about 50 wt% of the total weight of the hydrogel composition.

METHODS OF FORMING IONICALLY CROSS-LINKED GELS

The present invention relates to the formation of gels. In particular, the present invention is directed to a method of forming a cross-linked polymer hydrogel using competitive ligand exchange.

PROCESS FOR PRODUCING POROUS ALGINATE-BASED AEROGELS

The present invention relates to a process for preparing a porous material, at least comprising the steps of providing a mixture (I) comprising a water soluble polysaccharide, at least one compound suitable to react as cross-linker for the polysaccharide or to release a cross-linker for the polysaccharide, and water, and preparing a gel (A) comprising exposing mixture (I) to carbon dioxide at a pressure in the range of from 20 to 100 bar for a time sufficient to form a gel (A), and depressurizing the gel (A). Gel (A) subsequently is exposed to a water miscible solvent (L) to obtain a gel (B), which is dried. The invention further relates to the porous materials which can be obtained in this way and the use of the porous materials as thermal insulation material, for cosmetic applications, for biomedical applications or for pharmaceutical applications.

TRUE SPHERICAL POLYMER PARTICLES AND METHOD FOR THEIR PRODUCTION

True spherical fine particles of a water soluble polymer or a crosslinked product thereof, and a method for their production are disclosed. The method comprises spray drying an aqueous solution of a mixture of a water-soluble polymer and an additive such as a polyhydric alcohol or an oligosaccharide. The removal of the additive may be made only by crosslinking or washing the particles.

Self-foaming acidic composition and method of preparation

Une composition auto-moussante en milieu acide comprenant au moins :- un polymère hydrophile, - un composé capable de réticuler le polymère hydrophile par la formation de liaisons ioniques,- un agent moussant, et - un agent stabilisant des mousses, ladite composition étant sous la forme d’une poudre constituée de particules dont la granulométrie va de 10 nm à 2 mm et dans laquelle au moins 20% des particules présentent une granulométrie supérieure ou égale à 100 nm.

PROCESS FOR PREPARING A POROUS LAYER

The present invention relates to a process for preparing a porous layer of biocompatible polymer, having a uniform density and porosity, comprising the following steps: - a) a quantity Qp of solution of the said polymer, having a viscosity Vp, is poured into a mould in order to form a first sublayer, the surface of the first sublayer being left to the open air; - b) a quantity Qs of solvent, having a viscosity Vs, lower than Vp, is spread uniformly over the surface of the first sublayer so as to form a second sublayer; - c) the first and second sublayers are subjected to a step of lyophilisation, in which the said polymer is a polysaccharide chosen from hyaluronic acid, alginic acid and chitosan, salts thereof and mixtures thereof.

METHOD FOR PRODUCING A FOAM

L'invention concerne un procédé de production d'une matière plastique alvéolaire à partir de matières premières renouvelables, notamment de matière premières croissant naturellement comme les algues. Ce procédé comporte les opérations suivantes: traitement de matières premières ayant une teneur minimale de 3 % en masse d'alginat pour obtenir une première solution réactionnelle contenant un alginat soluble dans l'eau et préparation d'une source d'ions de calcium pour obtenir une deuxième solution réactionnelle; saturation au moins d'une solution réactionnelle par un agent moussant; réunion des solutions réactionnelles pour obtenir un alginat de calcium soluble dans l'eau et moussage simultané; séchage; formage et éventuellement traitement postérieur selon les finalités d'utilisation spécifiques.

Method for Preparing Porous Scaffold for Tissue Engineering, Cell Culture and Cell Delivery

The present invention relates to a method for preparing a porous scaffold for tissue engineering. It is another object of the present invention to provide a porous scaffold obtainable by the method as above described, and its use for tissue engineering, cell culture and cell delivery. The method of the invention comprises the steps consisting of: a) preparing an alkaline aqueous solution comprising an amount of at least one polysaccharide, an amount of a cross-linking agent and an amount of a porogen agent b) transforming the solution into a hydrogel by placing said solution at a temperature from about 4° C. to about 80° C. for a sufficient time to allow the cross-linking of said amount of polysaccharide and c) submerging said hydrogel into an aqueous solution d) washing the porous scaffold obtained at step c).

"Amido-phosphonate or amido-bisphosphonate derivatives of carboxylated polysaccharides, preparation and biomedical uses thereof"

Disclosed are carboxylated polysaccharides amido-phosphonated or amido-bis-phosphonated derivatives obtained by reaction of polysaccharides with nitrogen containing bisphosphonates or aminoalkyl phosphonic acid or imino(dialkyl phosphonic acid), and their use in the preparation of pharmaceutical formulations.

METHOD FOR PRODUCING ALGINATE-CONTAINING POROUS SHAPED BODIES

Process for the preparation of a flexible calcium alginate film

АЛЬГИНАТНАЯ КАМЕДЬ

Группа изобретений относится к биотехнологии и области сыроделия. Порошок частиц альгинатной камеди в непокрытой форме характеризуется содержанием сухих твердых веществ от 80 до 100% вес./вес., содержит от 0,4 до 1,6% вес./вес. ионов кальция от общего содержания сухих твердых веществ и практически нерастворим в молоке. Способ образования частиц альгинатной камеди в сухой форме с получением порошка реализуют следующим образом. Смешивают альгиновую кислоту с солью кальция с получением смеси, где содержание ионов кальция после смешивания с кальциевой солью составляет от 0,4 до 1,6% вес./вес. ионов кальция от общего содержания сухих твердых веществ. Доводят pH полученной смеси от 5,0 до 8,0. Высушивают смесь с получением альгинатной камеди в сухой форме, где содержание сухих твердых веществ составляет от 80 до 100% вес./вес. Измельчают высушенную смесь в порошок, состоящий из частиц с размером от 10 до 200 мкм. Способ промышленного производства сыра из молока реализуют следующим образом. Добавляют ...

АЛЬГИНАТНАЯ КАМЕДЬ

1. Частица или частицы альгинатной камеди, где частица или частицы - в непокрытой форме - характеризуются содержанием сухих твердых веществ от 80% до 100% вес./вес.; и где частица или частицы - в непокрытой форме - содержат от 0,4% до 1,6% вес./вес. ионов кальция от общего содержания сухих твердых веществ.2. Частицы альгинатной камеди по п. 1, содержащие по меньшей мере 50% вес./вес. альгината, предпочтительно по меньшей мере 75% вес./вес. альгината, более предпочтительно по меньшей мере 80% вес./вес. альгината, наиболее предпочтительно по меньшей мере 90% вес./вес. альгината.3. Частица или частицы альгинатной камеди по п. 1 или 2, характеризующиеся размером частиц от 20 мкм до 200 мкм в непокрытой форме.4. Частица или частицы альгинатной камеди по п. 1, дополнительно содержащие покрывающий материал.5. Частица или частицы альгинатной камеди по п. 1, которые практически нерастворимы в молоке.6. Частица или частицы альгинатной камеди по п. 1, характеризующиеся содержанием сухих твердых веществ от 80% до 100% вес./вес. альгината натрия и от 0,4% до 1,6% вес./вес. ионов кальция от общего содержания сухих твердых веществ.7. Способ образования альгинатной камеди в сухой форме, при этом указанный способ включает этапы:a. смешивания альгиновой кислоты с солью кальция с получением смеси;b. доведения pH полученной смеси до pH от 5,0 до 8,0;c. высушивания смеси с получением альгинатной камеди в сухой форме.8. Способ по п. 7, где кальциевая соль представляет собой хлорид кальция.9. Способ по п. 7 или 8, где содержание ионов кальция после смешивания с кальциевой солью на этапе a) составляет от 0,4% до 1,6% вес./вес. ионов кальция от общего содержания сухих твердых веществ.10. Способ п. 7, где pH на этапе b) доводят до значения от 5,0 до 8,0.11. Способ п. 7, где pH доводят путем добавления карбонатной соли РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2015 119 681 A (51) МПК A23C 9/154 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ЗАЯВКА НА ИЗОБРЕТЕНИЕ (21)(22) ...

Alginate monomer structure embedded with metal crystallite, alginate salt structure and alginate hydrogel thereof

Improvements in or relating to the production of films of alginic material

Transparent films are prepared by extruding a solution of a soluble alginate, which alginate has a viscosity of not less than 10 centipoises at 15 DEG C. in a 1 per cent solution, into a bath of a precipitant containing calcium ions, for example, a calcium chloride solution. In an example, calcium alginate having a viscosity of 250 centipoises is soaked in hydrochloric acid, and the alginic acid dissolved in sodium carbonate solution to give a 7 per cent solution. This solution is extruded through a slot into a 10 per cent solution of calcium chloride, and the film washed and passed through a glycerol bath. Specification 415,042 is referred to.

Compositions of semi-interpenetrating polymer network

Methods of forming ionically cross-linked gels

The present invention relates to the formation of gels. In particular, the present invention is directed to a method of forming a cross-linked polymer hydrogel using competitive ligand exchange.

HIGH-AMYLOSE SODIUM CARBOXYMETHYL STARCH SUSTAINED RELEASE EXCIPIENT AND PROCESS FOR PREPARING THE SAME

High-amylose sodium carboxymethyl starch (HASCA), produced by spray- drying (SD), was previously shown to have interesting properties as a promising pharmaceutical sustained drug-release tablet excipient for direct compression, including ease of manufacture and high crushing strength values. This study describes the effects of some important formulation parameters, such as compression force (CF), tablet weight (TW), drug-loading and electrolyte particle size, on acetaminophen-release performances from sustained drug- release matrix tablets based on HASCA. An interesting linear relationship between TW and release time was observed for a typical formulation of the system consisting of 40% w/w acetaminophen as model drug and 27.5% NaCI as model electrolyte dry-mixed with HASCA. Application of the Peppas and Sahlin model gave a better understanding of the mechanisms involved in drug-release from the HASCA matrix system, which is mainly controlled by surface gel layer formation. Indeed, augmenting ...

COMPOSITION THAT IS SELF-FOAMING IN AN ACID MEDIUM, AND METHOD FOR PREPARING SAME

Une composition auto-moussante en milieu acide comprenant : - au moins un polymère hydrophile, - au moins un composé capable de réticuler le polymère hydrophile par la formation de liaisons ioniques, - au moins un agent moussant, et - au moins un agent stabilisant des mousses, et son utilisation comme médicament, notamment pour la prévention et/ou le traitement de l'obésité.

METHOD FOR PREPARING POROUS SCAFFOLD FOR TISSUE ENGINEERING, CELL CULTURE AND CELL DELIVERY

The present invention relates to a method for preparing a porous scaffold for tissue engineering. It is another object of the present invention to provide a porous scaffold obtainable by the method as above described, and its use for tissue engineering, cell culture and cell delivery. The method of the invention comprises the steps consisting of: a) preparing an alkaline aqueous solution comprising an amount of at least one polysaccharide, an amount of a cross-linking agent and an amount of a porogen agent b) transforming the solution into a hydrogel by placing said solution at a temperature from about 4°C to about 80°C for a sufficient time to allow the cross-linking of said amount of polysaccharide and c) submerging said hydrogel into an aqueous solution d) washing the porous scaffold obtained at step c).

HYDROGEL MEMBRANE FOR ADHESION PREVENTION

A biocompatible membrane comprised of alginate and hyaluronate. The membrane may be used to prevent unwanted scarring after surgery. The tissue adherence and the rate of bioresorption of the membrane may be modified through an external stimulus comprising a sequestering agent and a viscosity modifier.

MAGNETIC POLYMER PELLETS AND A METHOD OF GENERATING THE BLOCKING GEL PLUG

The invention is related to magnetic polymer pellets represented as polymer matrix and solid filler as well as to their application for gel plugs' formation. As per the invention the polymer pellet is represented as gel matrix from anionic polymer cross-linked with cations of multivalent metals in which ferromagnetic micro-particles are dispersed with the ratio of the ferromagnetic micro-particles and anionic polymer concentrations from 0.5 to 5. The locking gel plug formation method provides the delivery of polymer pellets to the gel plug formation zone and the locking gel plug is formed due to the ambient medium pH increase to pH > 7 in the confined volume where they are retained by the external magnetic field.

WELLBORE SERVICING FLUID COMPOSITIONS AND USE THEREOF

A method of servicing a wellbore in contact with a subterranean formation comprising placing a wellbore servicing fluid comprising a polyuronide polymer within the wellbore, contacting the wellbore servicing fluid with a divalent ion source, and allowing the wellbore servicing fluid to form a gel within the wellbore wherein the divalent ion source is located within the wellbore. A method of servicing a wellbore in contact with a subterranean formation comprising (a) placing a wellbore servicing fluid comprising a polyuronide polymer into the wellbore wherein the wellbore servicing fluid contacts a calcium ion source, (b) shutting the wellbore and allowing the servicing fluid to set into place for a period of time, and (c) repeating steps (a) and (b) until the permeability of a structure within the wellbore is reduced by about 50%.

Edible composite film, and preparing method and application thereof

Method for separating and recycling mixed heavy metal by using calcium alginate membrane

Composition for the manufacture of a film substantially biodegradable and resulting film.

PROCEDE DE PREPARATION D'UN FILM SOUPLE D'ALGINATE DE CALCIUM

La présente invention concerne un procédé de préparation d'un film souple d'alginate de calcium. Selon l'invention on mélange une solution d'alginate de sodium avec une solution de chlorure de calcium sous agitation contrôlée, en présence d'un gaz inerte, on élimine le chlorure de sodium formé, on congèle rapidement l'émulsion produite, puis on lyophilise l'émulsion ...

Method for producing a closed-porosity foam

PROCESS FOR ATTAINMENT OF SODIUM A DRY STARCH SPRAY CARBOXIMETILA WITH HIGH AMILOSE; EXCIPIENTE TO LIBERATE SUPPORTED STARCH OF CARBOXIMETILA OF SODIUM WITH HIGH AMILOSE SPRAYED THE DRY ONE, USE OF THIS EXCIPIENTE AND COMPRESSED FOR THE SUPPORTED RELEASE OF THE LEAST A DRUG

SUBTERRANEAN FLUIDS CONTAINING SUSPENDED POLYMER BODIES

An aqueous suspension of polymer bodies is made by coalescing polymer from a flowing aqueous solution. These suspended bodies may be fibrous in appearance. However, the coalescence of the polymer bodies may be controlled to produce shapes. The coalesced polymer bodies are used for treating a downhole location within or accessed by a borehole. The bodies may be formed by coalescence at the surface and then pumped downhole or may be formed by coalescence downhole. Coalescence of polymer may result from crosslinking, complexing with material of opposite charge, or change in the polymer solution temperature, pH, solute concentration or solvent. The coalesced polymer bodies are maintained in aqueous solution after coalescence, and are not removed from solution for strengthening. 1. A method of treating a downhole location within or accessed by a borehole , the method comprising:coalescing polymer from a flowing aqueous polymer solution to generate an aqueous suspension of coalesced bodies of polymer, andproviding the aqueous suspension of coalesced bodies at the downhole location.2. The method according to claim 1 , wherein the coalesced polymer bodies are formed by coalescence of polymer at the surface and the aqueous suspension of bodies of polymer is delivered through at least one pump into the borehole claim 1 , wherein the pump is configured to convey the aqueous suspension of bodies of polymer downhole.3. The method according to claim 1 , wherein the aqueous polymer solution is delivered through at least one pump into the borehole and the coalesced polymer bodies of polymer are formed by coalescence of the polymer underground.4. The method according to claim 1 , wherein the coalescing the polymer is brought about by crosslinking polymer molecules to form the coalesced polymer bodies in the aqueous suspension of bodies of polymer.5. The method according to claim 1 , wherein the polymer comprises an ionic charge and the coalescing the polymer is brought about by ...

BIOCOMPATIBLE HYDROGEL CAPSULES AND PROCESS FOR PREPARING SAME

Described herein are compositions and methods for preparing hydrogel capsules using a cross-linking solution comprising a process additive. The process additive improves the quality of the resulting hydrogel capsules, such as increasing the number of defect-free capsules. 117-. (canceled)18. A process for preparing a hydrogel capsule composition from a polymer solution which comprises at least one afibrotic hydrogel-forming polymer and optionally an unmodified hydrogel-forming polymer , the process comprising contacting a plurality of droplets of the polymer solution with an aqueous cross-linking solution for a period of time sufficient to produce hydrogel capsules , wherein the cross-linking solution comprises a cross-linking agent , a buffer , an osmolarity-adjusting agent and a process additive , wherein the process additive is an amphiphilic compound.19. The process of claim 18 , wherein the polymer solution further comprises a cell suspension comprising a plurality of cells.20. The process of claim 19 , wherein the process additive reduces the surface tension of the cross-linking solution by about 1% claim 19 , about 2% claim 19 , about 5% claim 19 , about 10% claim 19 , about 15% claim 19 , about 20% claim 19 , about 25% claim 19 , about 30% claim 19 , about 35% claim 19 , about 40% claim 19 , about 45% claim 19 , about 50% claim 19 , or more.21. The process of claim 19 , wherein at least 95% of the hydrogel capsules in the hydrogel capsule composition are spherical capsules.22. The process of claim 19 , wherein the process additive is a surfactant or a non-ionic surfactant claim 19 , and the process additive is present in the cross-linking solution at a concentration of 0.001% to about 0.1% claim 19 , about 0.005% to about 0.05% claim 19 , about 0.005% to about 0.01% claim 19 , or about 0.01% to about 0.05%.23. The process of claim 22 , wherein the process additive is a poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) triblock ...

DEPOLYMERISATION OF ALGINIC ACID

Depolymerisation of alginic acid by microwave treatment. 1. A method of depolymerisation of alginic acid , said method comprising the steps of:a) providing alginic acid as a starting material for step b, wherein the alginic acid starting material has a pH in the range of 0-4.4 and wherein the dry matter content of the alginic acid starting material is in the range of 5-100% w/w, andb) treating said alginic acid starting material with microwave irradiation to obtain a depolymerised alginic acid material.2. The method according to claim 1 , wherein the microwave frequency is between 300 MHz and 300 GHz claim 1 , such as 300 MHz to 30 GHz claim 1 , preferably 300 MHz to 3 GHz.3. The method according to claim 1 , wherein the concentration of alginic acid in the alginic acid starting material is in the range of 7.5-100% w/w based on dry matter claim 1 , such as in the range of 80-100% w/w based on dry matter claim 1 , preferably in the range of 90-100% w/w based on dry matter.4. The method according to claim 1 , wherein the alginic acid starting material has a pH in the range of 0-3.5.5. The method according to claim 1 , wherein the dry matter content of the alginic acid starting material is in the range of 5-90% w/w.6. The method according to claim 1 , wherein the starting alginic acid material has a weight average molecular weight of 1 claim 1 ,500 claim 1 ,000-50 claim 1 ,000 Da.7. The method according to claim 1 , wherein the alginic acid starting material comprises alginic acid in a mixture with one or more selected solvents from the group consisting of water claim 1 , methanol claim 1 , ethanol claim 1 , and isopropanol.8. The method according to claim 1 , wherein the alginic acid starting material comprises alginic acid in water.9. The method according to claim 1 , wherein the alginic acid starting material further comprises a reducing and/or oxidizing agent.10. The method according to claim 1 , wherein the alginic acid starting material is drained and/or pressed ...

ENCAPSULATION BY CROSS-LINKING OF ANIONIC POLYMERS BY PH INDUCED DISSOCIATION OF CATION-CHELATE COMPLEXES

Microencapsulation methods are provided using encapsulant, fiber or film forming compositions of a cross-linkable anionic polymer, a multivalent cation salt, a chelating agent, and a volatile base. During the formation of this composition, the generally acidic chelating agent is titrated with a volatile base to an elevated pH to improve ion-binding capability. Multivalent cations are sequestered in cation-chelate complexes. Cross-linkable polymers in this solution will remain freely dissolved until some disruption of equilibrium induces the release of the free multivalent cations from the cation-chelate complex. Vaporization of the volatile base drops the pH of the solution causing the cation-chelate complexes to dissociate and liberate multivalent cations that associate with the anionic polymer to form a cross-linked matrix. During spray-drying, the formation of a wet particle, polymer cross-linking, and particle drying occur nearly simultaneously. 1. A method of cross-linking polymer molecules , the method comprising:(a) providing a solution of an acidic chelating agent with a volatile base;(b) adding at least one source of multivalent cations to form cation-chelate complexes in the solution;(c) mixing molecules of at least one anionic polymer with the solution of cation-chelate complexes and volatile base; and(d) vaporizing the volatile base of the solution, thereby disassociating the cation-chelate complexes and releasing multivalent cations and cross-linking the polymer molecules with said multivalent cations.2. The method of claim 1 , said acidic chelating agent solution further comprising a weak acid buffer.3. The method of claim 2 , wherein said weak acid is an acid selected from the group consisting of benzoic acid claim 2 , lactic acid claim 2 , ascorbic acid claim 2 , adipic acid claim 2 , acrylic acid claim 2 , glutaric acid claim 2 , ascorbic acid claim 2 , gallic acid claim 2 , caffeic acid claim 2 , L-Tartaric acid claim 2 , D-Tartaric acid claim 2 , ...

Method for Preparing Porous Scaffold for Tissue Engineering, Cell Culture and Cell Delivery

The present invention relates to a method for preparing a porous scaffold for tissue engineering. It is another object of the present invention to provide a porous scaffold obtainable by the method as above described, and its use for tissue engineering, cell culture and cell delivery. The method of the invention comprises the steps consisting of: a) preparing an alkaline aqueous solution comprising an amount of at least one polysaccharide, an amount of a cross-linking agent and an amount of a porogen agent b) transforming the solution into a hydrogel by placing said solution at a temperature from about 4° C. to about 80° C. for a sufficient time to allow the cross-linking of said amount of polysaccharide and c) submerging said hydrogel into an aqueous solution d) washing the porous scaffold obtained at step c).

ALGINATE MICROCAPSULES FOR CELL ENCAPSULATION AND, MANUFACTURING METHOD THEREFOR

The present disclosure provides a surface-modified alginate micro-capsule having a core-shell structure in which a core is fluidizable phase alginate, and a shell is alginate hydrogel crosslinked with epigallocatechin gallate dimer, a preparation method thereof, and a cell encapsulation method using the same. 1. A surface-modified alginate micro-capsule comprising a core-shell structure in which a core is fluidizable phase alginate , and a shell is alginate hydrogel crosslinked with epigallocatechin gallate dimers.2. The surface-modified alginate micro-capsule of claim 1 , wherein some of the epigallocatechin gallate dimers of the shell are coupled to other epigallocatechin gallate dimers via oxidation.3. The surface-modified alginate micro-capsule of claim 1 , wherein the shell further comprises an alginate coating layer.4. The surface-modified alginate micro-capsule of claim 3 , wherein the alginate coating layer comprises an amide bond with the epigallocatechin gallate dimer of the shell.5. The surface-modified alginate micro-capsule of claim 1 , wherein the shell comprises a plurality of hollows connected to each other in a three-dimensional manner.6. The surface-modified alginate micro-capsule of claim 1 , wherein the core is a liquid phase alginate or a mixture of liquid phase alginate and alginate hydrogel.7. The surface-modified alginate micro-capsule of claim 1 , wherein the micro-capsule provides for cell encapsulation.8. A method for preparing a surface-modified alginate micro-capsule claim 1 , the method comprising:(1) a core preparation step of preparing a calcium-alginate micro-capsule;(2) a shell preparation step in which an alginate-epigallocatechin gallate dimer crosslinked product is formed on a surface of the calcium-alginate micro-capsule by reacting the calcium-alginate micro-capsule and epigallocatechin gallate dimers with each other; and(3) a core liquefaction step of chelating calcium ions of calcium-alginate to the epigallocatechin gallate ...

HIGH-PERFORMANCE ELECTRODES WITH A POLYMER NETWORK HAVING ELECTROACTIVE MATERIALS CHEMICALLY ATTACHED THERETO

High performance electrodes for electrochemical devices having a polymer network with an electroactive material chemically attached to a crosslinked polymer matrix are disclosed. A method includes mixing an electrode slurry and forming a polymer network within the electrode slurry. The electrode slurry includes an electroactive material, an electrically conductive filler, a plurality of polymer chains, and a plurality of chemical crosslinking precursors. Each chemically crosslinking precursor is configured to (i) chemically crosslink the plurality of polymer chains and (ii) chemically attach the electroactive material to the plurality of polymer chains. 1. A method comprising:mixing an electrode slurry including an electroactive material, an electrically conductive filler, a plurality of polyacrylic acid polymer chains, and a plurality of isocyanate chemical crosslinking precursors, each of the chemical crosslinking precursors chemically crosslinking the plurality of polymer chains and chemically attaching the electroactive material to the plurality of polymer chains; andforming a polymer network within the electrode slurry.2. The method of claim 1 , further comprising:applying the electrode slurry having the polymer network suspended therein to a current collector; anddrying the electrode slurry to thereby form an electrode.3. The method of claim 1 , further comprising grafting the plurality of chemical crosslinking precursors to the plurality of polymer chains claim 1 , the grafting including:mixing the plurality of chemical crosslinking precursors with the plurality of polymer chains to thereby form a grafting solution; andresting the grafting solution for at least about ten minutes prior to forming the polymer network such that substantially all of the plurality of chemical crosslinking precursors is grafted to the plurality of polymer chains.4. The method of claim 1 , wherein the plurality of chemical crosslinking precursors is selected from a group consisting ...

Process for continuous supercritical drying of aerogel particles

Processes for drying gel particles, in particular for producing aerogels, involve providing a suspension containing gel particles and a solvent, introducing the suspension into a column where carbon dioxide flows in countercurrent, and removing dried aerogel particles from the column. The suspension is introduced in the top region of the column and dried aerogel particles are removed in the lower region. Pressure and temperature in the column are set such that the mixture of carbon dioxide and solvent is virtually supercritical or is supercritical. The aerogel particles can be discharged via discharge vessels or continuous decompression. Aerogel particles can be obtained by such a process and the aerogel particles can be used for medical and pharmaceutical applications, as additive or carrier material for additives for foods, as catalyst support, for cosmetic, hygiene, washing and cleaning applications, for production of sensors, for thermal insulation, or as a core material for VIPs.

INJECTABLE HYDROGEL-FORMING POLYMER SOLUTION FOR A RELIABLE EEG MONITORING AND EASY SCALP CLEANING

An injectable composition is described, which is capable of forming an hydrogel for electroencephalography (EEG) recording. The obtained hydrogel and method for its production is also an object of the invention, as well as the use of the injectable composition for EEG recording. 1. Injectable hydrogel-forming polymeric composition that is capable of forming a hydrogel for reliable EEG monitoring and an easy scalp cleaning characterized by comprising: a first component , selected from the group consisting of natural and synthetic polymers; a second component , selected from the group consisting of a polymerization initiation system or a cross-linking agent.2. Injectable hydrogel-forming composition according characterized in that the first component is a solution comprising alginate claim 1 , and the second component is a solution comprising calcium salts.3. Injectable hydrogel-forming composition according to characterized in that the first component further comprises at least one ionized salt in a concentration ranging from 0.1% to 10% to provide adequate electrical conductivity.4. Injectable hydrogel-forming composition according to characterized in that the first component further contains a humectant claim 1 , preferably glycerol or propylene glycol claim 1 , and a skin penetration enhancer claim 1 , preferably Tween®80.5. Injectable hydrogel-forming composition according to characterized in that the first component is a solution comprising 2.8% (w/v) sodium alginate claim 1 , 6% (v/v) Tween® 80 claim 1 , 10% (v/v) propylene glycol and 1.8% (w/v) sodium chloride; and the second component is a solution comprising 0.34% (w/v) calcium carbonate claim 1 , 0.14% (w/v) calcium sulfate dehydrate and 1.18% (w/v) gluconolactone.6. Hydrogel for reliable EEG monitoring and easy scalp cleaning claim 1 , formed of the injectable hydrogel-forming composition as claimed in .7. Hydrogel according to characterized in that the gelation rate is adjustable by changing the alginate ...

DEPOLYMERISATION OF ALGINIC ACID

Depolymerisation of alginic acid by microwave treatment. 1. A method of depolymerisation of alginic acid , said method comprising the steps of:(a) providing alginic acid as a starting material for step b, wherein the alginic acid starting material has a pH in the range of 0-4.4 and wherein the dry matter content of the alginic acid starting material is in the range of 15-70% w/w, and(b) treating said alginic acid starting material with microwave irradiation to obtain a depolymerised alginic acid material.2. The method according to claim 1 , wherein the microwave frequency is between 300 MHz and 300 GHz.3. The method according to claim 1 , wherein the concentration of alginic acid in the alginic acid starting material is in the range of 7.5-100% w/w based on dry matter.4. The method according to claim 1 , wherein the alginic acid starting material has a pH in the range of 0-3.5.5. (canceled)6. The method according to claim 1 , wherein the starting alginic acid material has a weight average molecular weight of 1 claim 1 ,500 claim 1 ,000-50 claim 1 ,000 Da.7. The method according to claim 1 , wherein the alginic acid starting material comprises alginic acid in a mixture with one or more solvents selected from the group consisting of water claim 1 , methanol claim 1 , ethanol claim 1 , and isopropanol.8. The method according to claim 1 , wherein the alginic acid starting material comprises alginic acid in water.9. The method according to claim 1 , wherein the alginic acid starting material further comprises a reducing and/or oxidizing agent.10. The method according to claim 1 , wherein the alginic acid starting material is drained and/or pressed and/or dried before the microwave treatment.11. The method to according to claim 1 , wherein the depolymerised alginic acid material has a weight average molecular weight of 300 claim 1 ,000-2 claim 1 ,000 Da.12. The method according to claim 1 , wherein the depolymerised alginic acid material is further neutralised after the ...

Photocrosslinked biodegradable hydrogel

A photocrosslinked biodegradable hydrogel includes a plurality of natural polymer macromers cross-linked with a plurality of hydrolyzable acrylate cross-links. The hydrogel is cytocompatible and produces substantially non-toxic products upon degradation.

HYDROGEL MEMBRANE FOR ADHESION PREVENTION

A biocompatible membrane comprised of alginate and hyaluronate. The membrane may be used to prevent unwanted scarring after surgery. The tissue adherence and the rate of bioresorption of the membrane may be modified through an external stimulus comprising a sequestering agent and a viscosity modifier. 1. A system comprising:hyaluronic acid and crosslinked alginate both included in a hydrogel; anda calcium chelator;wherein (a) the alginate is crosslinked with calcium, (b) the hydrogel is configured to increase in transparency in response to applying the calcium chelator to the hydrogel, and (c) the hydrogel is configured to leach the hyaluronic acid in response to applying the calcium chelator to the hydrogel, and (d) the hydrogel is not templated by a crystal.2. The system of claim 2 , wherein the calcium chelator includes at least one of citrate claim 2 , EDTA claim 2 , EGTA claim 2 , BAPTA claim 2 , a phosphate claim 2 , or combinations thereof.3. The system of claim 2 , wherein the hydrogel comprises:a first hydrogel layer comprising the hyaluronic acid and the crosslinked alginate; anda second hydrogel layer comprising collagen and additional hyaluronic acid.4. The system of wherein:the hydrogel comprises a therapeutic agent, the therapeutic agent including at least one of a drug, a pharmaceutical agent, a peptide, a protein, a medicine, a hormone, a macromolecule, or combinations thereof;the hydrogel is configured so the hydrogel's release rate of the therapeutic agent increases in response to applying the calcium chelator to the hydrogel.5. The system of claim 2 , wherein the hydrogel is configured so mucoadhesiveness of the hydrogel increases in response to applying the calcium chelator to the hydrogel.6. The system of wherein the hydrogel consists essentially of the hyaluronic acid claim 5 , the crosslinked alginate claim 5 , and water.7. The system of claim 1 , wherein the hydrogel includes uncrosslinked alginate.8. The system of claim 7 , wherein the ...

ANODE FOR NONAQUEOUS ELECTROLYTE SECONDARY CELL

An anode for a nonaqueous electrolyte secondary cell that can improve the cycle characteristics. In the anode for a nonaqueous electrolyte secondary cell, by modifying the surface of an active material with a polymer containing a carboxyl group, followed by bonding to a crosslinking binder, a stable SEI layer is formed and thus a mixture layer with high mechanical strength is provided, thereby better preventing detachment of the active material due to a volume change caused by charging and discharging, and thus providing an electrode for a secondary cell with good cycle characteristics. 1. An anode for a nonaqueous electrolyte secondary cell , comprising:an active material layer of an electrode, including a binder containing: an aqueous polysaccharide polymer having a carboxyl group, and an aqueous polymer having a carboxyl group with a number average molecular weight of 300,000 or less; andwherein crosslinking treatment is applied to the aqueous polysaccharide polymer having a carboxyl group.2. The anode for a nonaqueous electrolyte secondary cell of claim 1 , wherein:the aqueous polysaccharide polymer having a carboxyl group is completely neutralized, andthe aqueous polymer having a carboxyl group is an acidic polymer.3. The anode for a nonaqueous electrolyte secondary cell of claim 1 , wherein:the aqueous polysaccharide polymer having a carboxyl group is a sodium alginate.4. The anode for a nonaqueous electrolyte secondary cell of claim 1 , wherein:the aqueous polymer having a carboxyl group is a polyacrylic acid.5. The anode for a nonaqueous electrolyte secondary cell of claim 1 , wherein:{'sub': 'x', 'the active material in the active material layer of the electrode contains SiO.'} This application is a continuation application filed under 35 U.S.C. §111(a) claiming the benefit under 35 U.S.C. §§120 and 365(c) of International Application No. PCT/JP2016/064466, filed May 16, 2016, which is based upon and claims the benefit of priority of Japanese Patent ...

HIGHLY-SWELLABLE POLYMERIC FILMS AND COMPOSITIONS COMPRISING THE SAME

Highly-swellable polymeric films are provided. Aspects also include ingestible compositions that include the highly-swellable polymeric film and an ingestible component. Aspects further include methods of making and using the compositions. 139.-. (canceled)40. A device comprising:a framework;a control device coupled to the framework;a partial power source coupled to the control device and configured to provide power to the control device when activated, the partial power source comprising an anode material and a cathode material; anda highly-swellable polymeric film that rapidly swells without disintegrating upon contact with an aqueous medium external to the device, and covers at least one of the anode material and the cathode material;{'claim-text': ['in a first mode of operation, increase shelf-life stability of the device by inhibiting reaction of at least one of the anode material and the cathode material with ambient moisture while the device is in storage; and', {'claim-text': ['swell upon contact with the aqueous medium; and', 'upon swelling, provide conduction between the aqueous medium and at least one of the anode material and the cathode material that the highly-swellable polymeric film is covering.'], '#text': 'in a second mode of operation:'}], '#text': 'wherein the highly-swellable polymeric film is pre-fabricated to:'}41. The device according to claim 40 , wherein the highly-swellable polymeric film rapidly swells to ten times or greater in volume upon contact with the aqueous medium.42. The device according to claim 41 , wherein the highly-swellable polymeric film swells to ten times or greater in volume within one minute or less upon contact with the aqueous medium.43. The device according to claim 40 , wherein the highly-swellable polymeric film is configured to absorb ten grams or more of water per gram of film upon contact the aqueous medium.44. The device according to claim 40 , wherein the highly-swellable polymeric film comprises an ionic ...

Process for preparing a porous material

The present invention is directed to a process for preparing a porous material, at least comprising the steps of providing a gel comprising a solvent (S), wherein the solvent (S) has a volume (V1), pressurizing the gel with carbon dioxide at a temperature and a pressure at which carbon dioxide solubilizes in the solvent (S) forming gas-expanded liquid (EL), wherein the gas-expanded liquid (EL) has a volume (V2) and (V2) is greater than (V1); removing supernatant liquid, and drying the gel. The present invention further is directed to the porous material obtained or obtainable according to the process as such as the use of the porous material according to the invention in particular for medical, biomedical and pharmaceutical applications or for thermal insulation.

PROCESS FOR PRODUCING POROUS ALGINATE-BASED AEROGELS

The present invention relates to a process for preparing a porous material, at least comprising the steps of providing a mixture (I) comprising a water soluble polysaccharide, at least one compound suitable to react as cross-linker for the polysaccharide or to release a cross-linker for the polysaccharide, and water, and preparing a gel (A) comprising exposing mixture (I) to carbon dioxide at a pressure in the range of from 20 to 100 bar for a time sufficient to form a gel (A), and depressurizing the gel (A). Gel (A) subsequently is exposed to a water miscible solvent (L) to obtain a gel (B), which is dried. The invention further relates to the porous materials which can be obtained in this way and the use of the porous materials as thermal insulation material, for cosmetic applications, for biomedical applications or for pharmaceutical applications. 1: A process for preparing a porous material , comprising: (i) a water soluble polysaccharide,', '(ii) a compound suitable to react as cross-linker for the polysaccharide or to release a cross-linker for the polysaccharide, and', '(iii) water;, 'a) providing a mixture (I) comprising'} b1) exposing the mixture (I) to carbon dioxide at a pressure in a range of from 20 to 100 bar for a time sufficient to form a gel (A), and', 'b2) depressurizing the gel (A);, 'b) preparing a gel (A) by a process comprising'}c) exposing the gel (A) to a water miscible solvent (L) to obtain a gel (B); andd) drying of the gel (B).2: The process according to claim 1 , wherein the water soluble polysaccharide is selected from the group consisting of agar claim 1 , alginate claim 1 , carrageenan claim 1 , cellulose claim 1 , hyaluronic acid claim 1 , pectin claim 1 , starch claim 1 , xanthan gum claim 1 , modified cellulose claim 1 , chitin claim 1 , chitosan claim 1 , and a mixture thereof.3: The process according to claim 1 , wherein the water soluble polysaccharide is an alginate.4: The process according to claim 1 , wherein the preparing in ...

HYDROGEL COMPOSITION WITH THERMOS-SENSITIVE AND IONIC REVERSIBLE PROPERTIES, CARRIER, METHOD FOR PREPARING AND METHOD OF USE THEREOF

The present disclosure provides a method for preparing a hydrogel composition with thermos-sensitive and ionic reversible properties and the hydrogel composition prepared by the method. Related application products of the hydrogel composition of the present disclosure include wound dressings, drug carriers, three-dimensional cellular scaffolds, soluble microspheres, and cell capture and release systems, wherein the hydrogel composition with thermos-sensitive and ionic reversible properties has good in vitro and in vivo stability and high biocompatibility, and is non-toxic. The hydrogel composition can be removed and replaced by washing with metal chelating aqueous solution at low temperature.

Novel crosslinked alginic acid

The present invention provides alginic acid derivatives represented by formula (I) and formula (II), and a novel crosslinked alginic acid obtained by carrying out a Huisgen reaction using an alginic acid derivative of formula (I) and an alginic acid derivative of formula (II). There are thereby provided novel alginic acid derivatives and a novel crosslinked alginic acid.

METHOD FOR MANUFACTURING WATER-INSOLUBLE MOLDED ARTICLE AND WATER-INSOLUBLE MOLDED ARTICLE

A process for producing a water-insoluble shaped material, including a step of treating a raw material shaped material containing a water-soluble salt of a polyanionic polysaccharide with a treatment liquid containing an acid anhydride to insolubilize the raw material shaped material in water, and the process makes it possible to simply produce a water-insoluble shaped material in which intrinsic characteristics of the polyanionic polysaccharide being a raw material are retained, which has a high safety in that a chemical crosslinking agent is not required, and which is useful as a medical material, a food material, a cosmetic material, and the like. 116-. (canceled)17. A water-insoluble shaped material , comprising polyanionic polysaccharide in an acid form , wherein the treating converts the water-soluble salt of the polyanionic polysaccharide to the polyanionic polysaccharide in an acid form, and', 'the acid anhydride does not form a covalent bond with the polyanionic polysaccharide in the acid form., 'wherein the water-insoluble shaped material is produced by a process comprising: treating a raw material shaped material that comprises a water-soluble salt of the polyanionic polysaccharide, with a treatment liquid comprising an acid anhydride so as to insolubilize the raw material shaped material in water and form the water-insoluble shaped material,'}18. The water-insoluble shaped material according to claim 17 ,wherein the water-insoluble shaped material is dissolved in an aqueous medium having a pH of 12 or higher.19. The water-insoluble shaped material according to claim 17 , being a medical material claim 17 , a food material claim 17 , or a cosmetic material. The present invention relates to a process for producing a water-insoluble shaped material, and also relates to a water-insoluble shaped material, an adhesion inhibitor, an injection material, and a sustained release preparation.It is known that polyanionic polysaccharides such as hyaluronic acid and ...

ALGINATE HYDROGEL COMPOSITIONS

The present application provides a semi-permeable hydrogel composition comprising an alginate matrix that is covalently crosslinked in its periphery to a multi-armed water soluble polymer, along with related methods and uses thereof. 1. A semi-permeable hydrogel composition comprising an alginate matrix covalently crosslinked in the periphery of the alginate matrix to a multi-armed water soluble polymer.2. The semi-permeable hydrogel composition of claim 1 , wherein the multi-armed water soluble polymer penetrates the periphery of the alginate matrix.3. The semi-permeable hydrogel composition of claim 1 , wherein the periphery of the alginate matrix is interlocked with and covalently crosslinked to the multi-armed water soluble polymer.4. The semi-permeable hydrogel composition of claim 1 , wherein the hydrogel composition further comprises 1-20 surface layers of alginate that is covalently crosslinked to a multi-armed water soluble polymer.5. The semi-permeable hydrogel composition of claim 1 , wherein the hydrogel composition further comprises a biocompatible surface layer claim 1 , wherein the biocompatible surface layer is covalently bonded to the semi-permeable hydrogel composition.6. (canceled)7. The hydrogel composition of claim 1 , wherein the hydrogel composition is stable for at least 30 days at 40° C. in 1 mM phosphate buffered saline.8. (canceled)9. The hydrogel composition of claim 7 , wherein the composition is characterized by a first tan delta value determined at the time the composition is subjected to storage at 40° C. in 1 mM phosphate buffered saline (day 0) claim 7 , and a second tan delta value determined after the composition has been stored for 30 days at 40° C. in 1 mM phosphate buffered saline; and wherein the first tan delta value and the second tan delta value are the same or differ by no more than about 0.05.10. The hydrogel composition of claim 7 , wherein the hydrogel maintains its semi-permeability after storage for 30 days at 40° C. ...

ELASTOMERIC NANOCOMPOSITE HYDROGELS

An elastomeric nanocomposite hydrogel includes first natural polymer macromers covalently crosslinked with second natural polymer macromer and physically crosslinked with a plurality of inorganic nanoparticles. The elastomeric nanocomposite hydrogel is cytocompatible, and, upon degradation, produce substantially non-toxic products. 1. A composition comprising:an elastomeric nanocomposite hydrogel that includes first natural polymer macromers covalently crosslinked with second natural polymer macromer and physically crosslinked with a plurality of inorganic nanoparticles, the elastomeric nanocomposite hydrogel being cytocompatible, and, upon degradation, produce substantially non-toxic products.2. The composition of claim 1 , wherein the elasticity of the hydrogel is substantially maintained during degradation.3. The composition of claim 1 , wherein the first natural polymer macromers are photocrosslinked with the second natural polymer macromers.4. The composition of claim 3 , wherein the first natural polymer macromers are acrylated and/or methacrylated polysaccharides claim 3 , which are optionally oxidized.5. The composition of claim 5 , wherein the first natural polymer macromers comprise acrylated and/or methacrylated alginates claim 5 , which are optionally oxidized.6. The composition of claim 5 , wherein the first natural polymer macromers form reversible physical crosslinks with the inorganic nanoparticles.7. The composition of claim 1 , wherein the second natural polymer macromers comprise acrylated and/or methacrylated gelatin.8. The composition of claim 1 , wherein the first natural polymer macromers comprise optionally oxidized acrylated and/or methacrylated polysaccharides and the second natural polymer macromers comprise acrylated and/or methacrylated gelatin and wherein methacrylate and/or acrylate groups of the optionally oxidized acrylated and/or methacrylated polysaccharides react with methacrylate and/or acrylate groups of the acrylated and/or ...

SHEAR-THINNING HYDROGEL, KIT AND METHOD OF PREPARATION

A shear-thinning hydrogel composition includes: a first polymer chain including: (i) a first plurality of units each having at least one of a monosaccharide and an amino acid; and (ii) a cross-linking group bound to the at least one of the monosaccharide and the amino acid of one of the first plurality of units via conversion of a carboxyl group of the unit to a peptide bond; a second polymer chain including a second plurality of the units; and a cross-linking additive connecting one of the second plurality of units to the first polymer chain via the cross-linking group. 123-. (canceled)24. A kit comprising: (i) a first plurality of units of hyaluronic acid, each unit having at least one monosaccharide; and', '(ii) a further plurality of units of alginate bound to the first plurality of units; and', '(iii) a cross-linking group comprising dopamine bound to the at least one monosaccharide of one of the first plurality of units via conversion of a carboxyl group of the unit to a peptide bond; and, 'a quantity of a powdered polymer including collagen and a first polymer chain, the first polymer chain includinga quantity of a cross-linking additive comprising a 2+ charged ion for connecting first and second chains of the polymer via the cross-linking group, the second chains of the polymer including a second plurality of the units, the cross-linking additive connecting one of the second plurality of units to the first polymer chain via the cross-linking group.25. The kit of claim 24 , wherein the quantity of the powdered polymer includes:a first quantity of a first powdered polymer, including a host cross-linking group bound to another of the first plurality of units via conversion of a carboxyl group of the other unit to a peptide bond; anda second quantity of a second powdered polymer, including a guest cross-linking group bound to one of the second plurality of the units, for binding with the host cross-linking group.2628-. (canceled)29. The kit of claim 24 , wherein ...

HYDROGEL, PREPARATION METHOD THEREOF, AND pH SENSOR COMPRISING THE SAME

A method for preparing a hydrogel that reversibly changes color depending on pH includes: (S) dissolving a carboxyl group-containing polysaccharide in buffer to obtain a polysaccharide solution; (S) adding a cross-linker solution composed of a mixture of an organic solvent and a cross-linker to the polysaccharide solution; (S) adding, to the cross-linker-containing polysaccharide solution resulting from step (S), an organic solution composed of a mixture of an organic solvent and a first organic compound containing an aromatic functional group having at least one hydroxyl group bonded thereto, to form a mixture solution, and allowing the mixture solution to react; (S) obtaining a polymer complex from the reaction mixture resulting from step (S); and (S) mixing the polymer complex from step (S) with an organic dye comprising a second organic compound containing an aromatic functional group having at least one hydroxyl group bonded thereto. 1. A pH sensor having a sample sensing region coated with a hydrogel , wherein the hydrogel comprises:a polymer complex comprising a first organic compound and a carboxyl group-containing polysaccharide bonded together by a peptide bond, the first organic compound containing an aromatic functional group which at least one hydroxyl group is bonded to; andan organic dye comprising a second organic compound containing an aromatic functional group which at least one hydroxyl group is bonded to.2. A method for preparing a hydrogel that reversibly changes color depending on pH , the method comprising the sequential steps:(S10) dissolving a carboxyl group-containing polysaccharide in buffer to obtain a polysaccharide solution;(S20) adding a cross-linker solution composed of a mixture of an organic solvent and a cross-linker to the polysaccharide solution;{'b': '20', '(S30) adding, to the cross-linker-containing polysaccharide solution resulting from step (S), an organic solution composed of a mixture of an organic solvent and a first ...

Photocontrolled dynamic covalent linkers for polymer networks

Reversibly crosslinkable polymeric networks, including reversibly crosslinkable hydrogel networks are provided. Also provided are methods of making the polymeric networks and methods of using the hydrogel networks in tissue engineering applications. The reversibly crosslinkable polymeric networks are composed of polymer chains that are covalently crosslinked by azobenzene boronic ester bonds that can be reversibly formed and broken by exposing the polymeric networks to different wavelengths of light.

COMPOSITION THAT IS SELF-FOAMING IN AN ACID MEDIUM, AND METHOD FOR PREPARING SAME

A composition that is self-foaming in an acid medium, and includes: at least one hydrophilic polymer, at least one compound capable of crosslinking the hydrophilic polymer by forming ionic bonds, at least one foaming agent, and at least one foam stabilizer agent; and to the use thereof as a drug, particularly for preventing and/or treating obesity. 116-. (canceled)17. A composition comprising:at least one hydrophilic polymer selected from polysaccharides, polysaccharide derivatives and mixtures thereof,at least one compound capable of crosslinking the hydrophilic polymer by forming ionic bonds, selected from the group consisting in the salts of divalent cations, the salts of trivalent cations and mixtures thereof,at least one foaming agent selected from salts capable of decomposing into gas and into monovalent cations, andat least one foam stabilizer.18. The composition as claimed in claim 17 , wherein the hydrophilic polymer is selected from the alginates.19. The composition as claimed in claim 17 , wherein the content by weight of hydrophilic polymer is from 10% to 99.5% claim 17 , the contents being expressed in weight of dry matter.20. The composition as claimed in claim 17 , wherein the compound capable of crosslinking the hydrophilic polymer by forming ionic bonds comprises at least one metal salt.21. The composition as claimed in claim 17 , wherein the compound capable of crosslinking the hydrophilic polymer by forming ionic bonds is selected from salts of divalent cations.22. The composition as claimed in claim 21 , wherein the compound capable of crosslinking the hydrophilic polymer by forming ionic bonds is chosen from the group consisting of calcium carbonate CaCO claim 21 , manganese carbonate MnCO claim 21 , silver carbonate AgCO claim 21 , iron carbonate FeCO claim 21 , copper carbonate CuCO claim 21 , magnesium carbonate MgCO claim 21 , hydroxyapatite Ca(PO)OHand mixtures thereof.23. The composition as claimed in claim 22 , wherein the compound ...

Sacrificial Templates Comprising a Hydrogel Cross-linking Agent and Their Use for Customization of Hydrogel Architecture

Described herein are sacrificial templates generated from water soluble thermoplastic-divalent cation-composite materials, such as poly(vinyl alcohol)-calcium. Also described herein are methods for the use of such sacrificial templates in casting of precise internal space microarchitectures within hydrogels, such as microchannel networks within alginate hydrogels. 1. A method for controlled fabrication of internal spaces in a biocompatible hydrogel comprising:(i) providing a sacrificial template that has a predefined shape and is immobilized within a casting chamber, wherein the sacrificial template comprises a water-soluble thermoplastic-divalent cationic salt composite material; and(ii) introducing into the casting chamber a volume of hydrogel polymer solution comprising a hydrogel polymer that is cross-linkable by divalent cations, wherein the volume is sufficient to surround the sacrificial template;whereby, (a) divalent cations diffuse out of the sacrificial template and cross-link the hydrogel polymer in the solution contacting the sacrificial template to form a hydrogel shell conforming to the shape of the sacrificial template; and (b) subsequent to formation of the hydrogel shell, the sacrificial template dissolves to form one or more internal spaces corresponding to the predefined shape.2. The method of claim 1 , wherein the water-soluble thermoplastic in the water-soluble thermoplastic-divalent cation composite material is selected from among poly(vinyl alcohol) claim 1 , poly(ethylene-oxide) claim 1 , poly(ethylene glycol) claim 1 , poly(lactic acid) claim 1 , poly(glycolic acid) claim 1 , and combinations thereof.3. The method of claim 2 , wherein water-soluble thermoplastic is poly(vinyl alcohol).4. The method of claim 3 , wherein the poly(vinyl alcohol)-divalent cationic composite material comprises calcium cations claim 3 , magnesium cations claim 3 , or barium cations.5. The method of claim 4 , wherein the poly(vinyl alcohol)-divalent cationic ...

Method and device for forming a gel particle slurry

A method of forming a gel particle slurry includes providing a first solution that includes a cross-linkable hydrogel polymer macromer and an optional first crosslinker in a first depot and optionally a second solution in a second depot that is separated from the first depot by a mixing unit that includes a mixing element; and reversibly transferring the first solution and the optional second solution through the mixing unit between the first depot and the second depot such that the first solution and the optional second solution are mixed and agitated to form the gel particle slurry.

AIR TREATMENT AND LONG TERM FRAGRANCE RELEASE GEL

A method for producing a crosslinked gel. The method comprises steps of: (a) combining (i) water, (ii) alginic acid, alginates, or mixtures thereof, (iii) carboxymethylcellulose, (iv) a salt of calcium, magnesium or zinc, (v) a nonionic surfactant and (vi) fragrance to form a gel having a surface; and (b) contacting with the surface of said gel an additional aqueous solution of a salt of calcium, magnesium or zinc. 1. A method for producing a crosslinked gel; said method comprising steps of:(a) combining (i) water, (ii) alginic acid, alginates, or mixtures thereof,(iii) carboxymethylcellulose, (iv) a salt of calcium, magnesium or zinc, (v) a nonionic surfactant and (vi) fragrance to form a gel having a surface; and(b) contacting with the surface of said gel an additional aqueous solution of a salt of calcium, magnesium or zinc.2. The method of in which the gel comprises from 86 to 96 wt % water claim 1 , from 0.3 to 2.5 wt. % carboxymethylcellulose; from 0.3 to 2.5 wt. % alginic acid claim 1 , alginates claim 1 , or mixtures thereof; from 0.1 to 1 wt % of a salt of calcium claim 1 , magnesium or zinc claim 1 , or a combination thereof; from 0.2 to 2 wt % nonionic surfactant and from 1 to 6 wt % of one or more fragrances; and wherein said aqueous solution is added in an amount from 0.1 to 1 wt % and comprises from 2 to 20 wt % of a salt of calcium claim 1 , magnesium or zinc.3. The method of in which the salt is a calcium salt.4. The method of in which the carboxymethylcellulose has a molar degree of substitution MSof from 0.3 to 1.8.5. The method of in which a portion of the additional aqueous solution of a calcium salt is coated on the inside of a mold prior to addition of the gel to the mold and a portion of the additional aqueous solution of a calcium salt is applied to any portion of the gel surface not in contact with the mold.6. The method of in which the gel comprises from 90 to 95 wt % water claim 5 , from 0.6 to 1.5 wt. % carboxymethylcellulose; from 0.6 to ...

Dendritic Macroporous Hydrogels Prepared By Crystal Templating

The present invention includes a hydrogel and a method of making a porous hydrogel by preparing an aqueous mixture of an uncrosslinked polymer and a crystallizable molecule; casting the mixture into a vessel; allowing the cast mixture to dry to form an amorphous hydrogel film; seeding the cast mixture with a seed crystal of the crystallizable molecule; growing the crystallizable molecule into a crystal structure within the uncrosslinked polymer; crosslinking the polymer around the crystal structure under conditions in which the crystal structure within the crosslinked polymer is maintained; and dissolving the crystals within the crosslinked polymer to form the porous hydrogel. 1. (canceled)2. An apparatus comprising:a hydrogel film having first and second opposing ends;wherein the hydrogel film includes (a)(i) uncrosslinked hyaluronic acid, (a)(ii) crosslinked alginate, and (a)(iii) at least one of a protein and a biomineral;wherein (b)(i) the alginate is crosslinked with calcium, and (b)(ii) the alginate is crosslinked around the uncrosslinked hyaluronic acid.3. The apparatus of wherein the hydrogel film includes the biomineral.4. The apparatus of wherein the hydrogel film includes the protein.5. The apparatus of wherein the protein includes a cell adhesive protein.6. The apparatus of wherein the hydrogel film includes a drug.7. The apparatus of included in a kit claim 4 , the kit comprising a calcium chelator.8. The apparatus of claim 4 , wherein the hydrogel film consists essentially of the uncrosslinked hyaluronic acid and the crosslinked alginate.9. The apparatus of wherein the hydrogel film includes chitosan.10. The apparatus of wherein the hydrogel film includes urea.11. The apparatus of wherein the hydrogel film includes at least one crystal.121. The apparatus of wherein the at least one crystal is (a) dendritically branched claim 11 , and (b) at least micron in diameter.13. The apparatus of wherein the at least one crystal comprises cyclodextrin.14. An ...

PHOTOCONTROLLED DYNAMIC COVALENT LINKERS FOR POLYMER NETWORKS

Reversibly crosslinkable polymeric networks, including reversibly crosslinkable hydrogel networks are provided. Also provided are methods of making the polymeric networks and methods of using the hydrogel networks in tissue engineering applications. The reversibly crosslinkable polymeric networks are composed of polymer chains that are covalently crosslinked by azobenzene boronic ester bonds that can be reversibly formed and broken by exposing the polymeric networks to different wavelengths of light. 1. A reversibly crosslinkable composition comprising:a first molecule comprising at least two terminal azobenzene boronic acid groups; anda second molecule comprising at least two terminal diol groups, wherein at least one of the first and second molecules is a polymer, and further wherein, if the first molecule has only two terminal azobenzene boronic acid groups, then the second molecule comprises at least three terminal diol groups, and if the second molecule has only two terminal diol groups, the first molecule has at least three terminal azobenzene boronic acid groups;wherein the first molecule is characterized in that its azobenzene groups undergo a reversible E to Z isomerization upon irradiation with ultraviolet light, visible light, or infrared light, and its boronic acid groups react with the terminal diol groups of the second polymer to form a polymer network comprising covalent azobenzene boronic ester bonds.2. The composition of claim 1 , wherein one or both of the first molecule and the second molecule comprise polysaccharide chains.3. The composition of claim 2 , wherein the polysaccharide chains comprise hyaluronic acid chains.4. The composition of claim 1 , wherein one or both of the first molecule and the second molecule comprise poly(ethylene glycol) chains.5. The composition of claim 1 , wherein one or both of the first molecule and the second molecule comprise decellularized extracellular matrix.6. The composition of claim 1 , wherein one or both of ...

POLYMER COMPOSITIONS

The invention relates to novel a high-volume swelling hydrogel which comprises a plurality of pores which are defined by an interpenetrating network, and/or a semi-interpenetrating network and/or simple cross-linked arrangement of a plurality of one or more species of hydrophilic polymers, optionally together with one or more biocompatible polymers and optionally together with one or more plasticising agents, characterised in that at least some of the pores are at least partially collapsed and/or flattened, and further characterised in that the interpenetrating network and/or semi-interpenetrating network and/or cross-linked arrangement which defines the collapsed and/or flattened pores is substantially unbroken. The invention also relates to a process for preparing such hydrogels, and to their use as an appetite suppressant. 16.-. (canceled)7. A process for preparing a compressed hydrogel comprising the steps:a) providing an initial hydrogel which comprises a plurality of pores which are defined by an interpenetrating network, or a semi-interpenetrating network or a simple cross-linked structure, and which is made from a composition comprising one or more hydrophilic polymers;b) treating the initial hydrogel with heat or water vapor or both and applying a compressive force suitable to reduce the volume of at least some of the pores of the initial hydrogel thereby to yield a compressed hydrogel.8. The process according to claim 7 , wherein the initial hydrogel comprises one or more additional ingredients selected from additional polymers and plasticizing agents.9. (canceled)10. The process according to claim 7 , wherein the treatment conditions in step b) comprise treating the initial hydrogel with steam.11. The process according to claim 7 , wherein the size of one or more of the pores of the initial hydrogel is reduced by at least a factor of 2 claim 7 , following the application of the compressive force in step b).12. The process according to claim 7 , wherein ...

HIGHLY EFFICACIOUS HEMOSTATIC ADHESIVE POLYMER SCAFFOLD

The invention relates to biocompatible polymer gel compositions useful in facilitating and maintaining hemostasis. The biocompatible polymeric gel composition is comprised of (a) one or more than one polyanionic polymer, (b) one or more than one polycationic polymer, and (c) a solvent. A preferred composition includes sodium alginate, chitosan, and water to produce an adhesive hemostatic device that is useful in facilitating and maintaining rapid hemostasis. 1. A polymeric composition comprising:a. about 0.1% to about 5% by weight of one or more than one polyanionic polymer;b. about 5% to about 40% by weight of one or more than one polycationic polymer; andc. about 50% to about 99.9% by weight solvent.2. A polymeric composition of wherein said one or more than one polyanionic polymer comprises sodium alginate claim 1 , wherein said one or more than one polycationic polymer comprises chitosan claim 1 , wherein said solvent is water.3. A polymeric composition of wherein the sodium alginate has a chain length of between about 1 claim 2 ,000 nm and about 3 claim 2 ,000 nm.4. A polymeric composition of wherein the sodium alginate has an average molecular weight of about 100 kDa to about 1 claim 2 ,000 kDa.5. A polymeric composition of wherein the sodium alginate has an average molecular weight of about 500 kDa to about 900 kDa.6. A polymeric composition of wherein the sodium alginate has an average molecular weight of about 800 kDa.7. A polymeric composition of wherein the chitosan has a chain length of between about 2 claim 2 ,000 nm and about 4 claim 2 ,000 nm.8. A polymeric composition of wherein the chitosan has a chain length of between about 2 claim 2 ,800 nm and about 2 claim 2 ,900 nm.9. A polymeric composition of wherein the chitosan has a chain length of about 2 claim 2 ,850 nm.10. A polymeric composition of wherein the chitosan has an average molecular weight of between about 1 kDa to about 2 claim 2 ,000 kDa.11. A polymeric composition of wherein the chitosan ...

POROUS GELS AND METHODS FOR THEIR PREPARATION

There is provided a method for preparing a porous gel. The method comprises using a porous polymer template. The porous gel according to the invention has a porosity that is continuous throughout the whole volume of the gel and that is tunable in terms of pore size distribution and average pore diameter. The porous gel can be used in various application. 1. A method for preparing a porous gel , comprising the steps of:(a) providing a porous polymer template;(b) injecting a precursor solution in the template, wherein the solution subsequently gels and a porous polymer and gel system is obtained; and(c) subjecting the porous polymer and gel system to an extraction process, wherein at least part of the polymer material is extracted and the porous gel is obtained.2. The method according to claim 1 , wherein step (a) comprises the steps of:(a1)) preparing a co-continuous mixture of polymer material to obtain a polymer blend;(a2) annealing the polymer blend; and(a3) selectively extracting a portion of the polymer material to obtain the porous polymer template.3. A method according to claim 2 , wherein the polymer material comprises at least two polymers claim 2 , the portion of the polymer material at step (a3) comprises one polymer and the polymer material at step (c) comprises at least one of the other polymers.4. A method for preparing a porous gel claim 2 , comprising the steps of:(a1) preparing a co-continuous mixture of at least two polymers to obtain a polymer blend;(a2) annealing the polymer blend;(a3) selectively extracting at least one polymer to obtain the porous polymer template;(b) injecting a precursor solution in the template, wherein the solution subsequently gels and a porous polymer and gel system is obtained; and(c) subjecting the porous polymer and gel system to an extraction process, wherein at least part of the polymer material is extracted and the porous gel is obtained.5. A method for preparing a porous gel claim 2 , comprising the steps of:(a1) ...

METHOD FOR MANUFACTURING WATER-INSOLUBLE MOLDED ARTICLE AND WATER-INSOLUBLE MOLDED ARTICLE

A process for producing a water-insoluble shaped material, including a step of treating a raw material shaped material containing a water-soluble salt of a polyanionic polysaccharide with a treatment liquid containing an acid anhydride to insolubilize the raw material shaped material in water, and the process makes it possible to simply produce a water-insoluble shaped material in which intrinsic characteristics of the polyanionic polysaccharide being a raw material are retained, which has a high safety in that a chemical crosslinking agent is not required, and which is useful as a medical material, a food material, a cosmetic material, and the like.

PROCESS FOR PREPARING BIOCOMPATIBLE AND BIODEGRADABLE POROUS THREE-DIMENSIONAL POLYMER MATRICES AND USES THEREOF

The present invention relates to a process for preparing a biocompatible and biodegradable, porous three-dimensional polymer matrix, to the porous polymer matrix obtained by means of such a process, and also to the uses thereof, in particular as a support and for cell culture or in regenerative medicine, and in particular for cell therapy, in particular cardiac cell therapy. 1. Process for preparing a biocompatible and biodegradable polymer matrix comprising a network of open and interconnected pores , said process comprising at least the following steps:1) preparing an aqueous solution comprising at least one biocompatible anionic polysaccharide and at least one biocompatible cationic polymer,2) mechanically stirring said solution obtained above in the preceding step, in the presence of a foaming agent or of a pressurized gas, so as to form a foam,3) freezing the foam obtained above in the preceding step, so as to obtain a frozen foam,4) gelling the frozen foam obtained above in the preceding step, by adding, to said foam, at least one gelling agent in solution in a solvent, so as to obtain a gelled foam,5) dehydrating the gelled foam obtained above in the preceding step, so as to obtain a dehydrated gelled foam, then{'sub': '2', '6) drying the dehydrated gelled foam obtained above in the preceding step, by treatment with supercritical CO, so as to obtain said polymer matrix.'}2. Process according to claim 1 , wherein the biocompatible anionic polysaccharide(s) have an average molecular weight (MwA) of greater than or equal to 75 000 Daltons.3. Process according to claim 1 , wherein the biocompatible anionic polysaccharide(s) are chosen from alginates and modified alginates.4. Process according to claim 1 , wherein the amount of anionic polysaccharides present in the aqueous solution of step 1) ranges from 0.5% to 8% by weight relative to the total weight of said aqueous solution.5. Process according to claim 1 , wherein the biocompatible cationic polymer(s) have ...

HYDROGEL MEMBRANE FOR ADHESION PREVENTION

A biocompatible membrane comprised of alginate and hyaluronate. The membrane may be used to prevent unwanted scarring after surgery. The tissue adherence and the rate of bioresorption of the membrane may be modified through an external stimulus comprising a sequestering agent and a viscosity modifier. 1uncrosslinked hyaluronic acid and crosslinked alginate both included in a hydrogel film; anda calcium chelator;wherein (a) the alginate is crosslinked with calcium, (b) the hydrogel film is flat and includes a width, a length, and a thickness that is less than the width and the length, and (c) the hydrogel film is configured so bioresorbability of the hydrogel film increases in response to applying the calcium chelator to the hydrogel film.. A kit comprising: This application is a continuation of U.S. patent Ser. No. 15/597,541, filed May 17, 2017, and titled “Hydrogel Membrane for Adhesion Prevention”, which is a continuation of U.S. patent application Ser. No. 14/758,873, filed Jul. 1, 2015, and titled “Hydrogel Membrane for Adhesion Prevention”, which issued on May 30, 2017 as U.S. Pat. No. 9,662,424, which is a § 371 National Stage Entry of International Application No. PCT/US2013/074388 filed on Dec. 11, 2013, and titled “Hydrogel Membrane for Adhesion Prevention”, which claims priority to: (1) U.S. Provisional Application No. 61/814,944 filed on Apr. 23, 2013, and titled “Multilayer Hydrogel”, (2) U.S. Provisional Application No. 61/807,629 filed on Apr. 2, 2013, and titled “Hydrogel Based Therapeutic Agent Delivery”, and (3) U.S. Provisional Application No. 61/735,852 filed on Dec. 11, 2012, and titled “Hydrogel Membrane for Adhesion Prevention”. The content of each of the above applications is hereby incorporated by reference.This invention was made with government support under Grant no. DMR0805298 awarded by the National Science Foundation. The government has certain rights in the invention.Embodiments of the invention relate generally to the field of ...

Dendritic Macroporous Hydrogels Prepared By Crystal Templating

The present invention includes a hydrogel and a method of making a porous hydrogel by preparing an aqueous mixture of an uncrosslinked polymer and a crystallizable molecule; casting the mixture into a vessel; allowing the cast mixture to dry to form an amorphous hydrogel film; seeding the cast mixture with a seed crystal of the crystallizable molecule; growing the crystallizable molecule into a crystal structure within the uncrosslinked polymer; crosslinking the polymer around the crystal structure under conditions in which the crystal structure within the crosslinked polymer is maintained; and dissolving the crystals within the crosslinked polymer to form the porous hydrogel. 1. An apparatus comprising:a hydrogel film having first and second opposing ends;chitosan included in the hydrogel film;urea included in the hydrogel film; andat least one crystal included in the hydrogel film;wherein the at least one crystal is (a) dendritically branched, (b) at least 1 micron in diameter, and (c) comprises the urea.2. The apparatus of claim 1 , wherein the hydrogel film has top and bottom surfaces connecting the first and second ends claim 1 , and the at least one crystal is distributed from the top surface to the bottom surface and from the first end to the second end.3. The apparatus of claim 1 ,wherein the at least one crystal forms a continuous crystal network, connecting the first and second ends, including first and second crystal portions parallel to one another; andthe apparatus further comprises a compressed fiber, including a ridge, compressed between the first and second crystal portions.4. The apparatus of claim 3 , wherein the compressed fiber is included in a plurality of compressed fibers formed among alternating valleys and ridges.5. The apparatus of claim 1 , wherein the at least one crystal forms a continuous crystal network. This application is a continuation of U.S. patent application Ser. No. 14/277,170, filed May 14, 2014 and entitled “DENDRITIC ...

Hydrogels with Improved Mechanical Properties Below Water Freezing Temperature

Hydrogel compositions, and corresponding methods of making, are provided. The hydrogels do not freeze, or only partially freeze, over a wide range of temperatures below the freezing temperature of water. Concurrently, these hydrogels also retain their room temperature mechanical properties (e.g., strength, modulus, elasticity) over a wide range of temperatures, including temperatures below the freezing temperature of water. The hydrogels are synthesized by adding a suitable amount of a salt together with previously cross-linked polymer gel. Hydration of the gel with aqueous solutions containing the prescribed salts not only depresses the hydrogel freezing point but protects the structure. For example, the salts do not allow the hydrogel to completely freeze, thus protecting the hydrogel from brittle failure. Whether the hydrogels partially freeze or remain non-frozen when chilled below the freezing temperature of water is determined by concentration of salt within the hydrogel.

ALGINATE MONOMER STRUCTURE WITH METAL CRYSTALLITE EMBEDDED, ALGINATE SALT STRUCTURE WITH METAL CRYSTALLITE EMBEDDED AND METHOD OF PRODUCING ALGINATE HYDROGEL WITH METAL CRYSTALLITE INCORPORATED

An alginate monomer structure with metal crystallite embedded includes a first alginate monomer and at least a first metal crystallite. The first alginate monomer is composed of a first uronate molecule and a second uronate molecule, which are linked linearly to each other. A first carbonyl group is formed on a second carbon atom (C2) of the main ring in the first uronate molecule, a carboxyl group is presented on a sixth carbon atom (C6) of the main ring in the second uronate molecule, and a first intramonomer glycosidic linkage is presented between a first carbon atom (C1) of the main ring in the first uronate molecule and a fourth carbon atom (C4) of the main ring in the second uronate molecule. The first metal crystallite is associated between the first uronate molecule and the second uronate molecule. 1. An alginate monomer structure with metal crystallite embedded , comprising:a first alginate monomer composed of a first uronate molecule and a second uronate molecule linked linear to each other, wherein a first carbonyl group is formed on a second carbon atom (C2) of a main ring in the first uronate molecule; and a first intramonomer glycosidic linkage is presented between a first carbon atom (C1) in the first uronate molecule and a fourth carbon atom (C4) in the second uronate molecule; andat least a first metal crystallite associated between the first uronate molecule and the second uronate molecule.2. The alginate monomer structure with metal crystallite embedded according to claim 1 , wherein a first carboxyl group is presented on the second uronate molecule claim 1 , and the at least a first metal crystallite is associated between the first carbonyl group and the first carboxyl group.3. The alginate monomer structure with metal crystallite embedded according to claim 1 , wherein the first uronate molecule and the second uronate molecule are selected from α-L-guluronate or β-D-mannuronate claim 1 , respectively.4. The alginate monomer structure with metal ...

Hydrogel Membrane for Adhesion Prevention

A biocompatible membrane comprised of alginate and hyaluronate. The membrane may be used to prevent unwanted scarring after surgery. The tissue adherence and the rate of bioresorption of the membrane may be modified through an external stimulus comprising a sequestering agent and a viscosity modifier. 1uncrosslinked hyaluronic acid and crosslinked alginate both included in a hydrogel film; anda calcium chelator;wherein (a) the alginate is crosslinked with calcium, (b) the hydrogel film is flat and includes a width, a length, and a thickness that is less than the width and the length, and (c) the hydrogel film is configured so bioresorbability of the hydrogel film increases in response to applying the calcium chelator to the hydrogel film.. A kit comprising: This application is a continuation of U.S. patent application Ser. No. 14/758,873, filed Jul. 1, 2015, which is a §371 National Stage Entry of International Application No. PCT/US2013/074388 filed on Dec. 11, 2013, which claims priority to: (1) U.S. Provisional Application No. 61/814,944 filed on Apr. 23, 2013, (2) U.S. Provisional Application No. 61/807,629 filed on Apr. 2, 2013, and (3) U.S. Provisional Application No. 61/735,852 filed on Dec. 11, 2012. The content of each of the above applications is hereby incorporated by reference.This invention was made with government support under Grant no. DMR0805298 awarded by the National Science Foundation. The government has certain rights in the invention.Embodiments of the invention relate generally to the field of medical devices and more particularly to devices that inhibit, reduce, and prevent scarring. Embodiments of the invention include a bioresorbable membrane that can be inserted into the body, between tissues and organs, to prevent unwanted scar tissue attachments.Scar tissue attachments, also called adhesions, are a frequent complication of surgical procedures. During a surgical procedure the tissues and organs of the body may be deliberately or ...

ALGINATE GUM

The present invention relates to an alginate gum, a method for formation of an alginate gum, optionally in particulate form, and methods of use and the use thereof for example in cheese production. 1. Alginate gum particle or particles , which particle or particles—in uncoated form—have a dry solids content between 80% and 100% w/w; and which particle or particles—in uncoated form—comprise between 0.4% and 1.6% w/w calcium ions on a dry solids basis.2. Alginate gum particles according to claim 1 , comprising at least 50% w/w alginate.3. Alginate gum particle or particles according to claim 1 , having a particle size of between 20 microns and 200 microns in uncoated form.4. Alginate gum particle or particles according to claim 1 , additionally comprising a coating material.5. Alginate gum particle or particles according to claim 1 , being substantially insoluble in milk.6. Alginate gum particle of particles according to claim 1 , comprising a dry solids content between 80% and 100% w/w of sodium alginate claim 1 , and between 0.4% and 1.6% w/w calcium ions on a dry solids basis.7. A method for formation of alginate gum in dry form claim 1 , said method comprising the steps of:a. mixing alginic acid with a calcium salt to obtain a mixture;b. adjusting the pH of the obtained mixture to a pH of between 5.0 and 8.0; andc. drying the mixture to provide alginate gum in dry form.8. The method according to claim 7 , wherein the calcium salt is calcium chloride.9. The method according to claim 7 , wherein the content of calcium ions after mixing with a calcium salt in step a) are between 0.4% and 1.6% w/w calcium ions on a dry solids basis.10. The method according to claim 7 , wherein the adjustment of pH in step b) is to a pH of between 5.0 and 8.0.11. The method according to claim 7 , wherein the adjustment of the pH takes place by addition of a metal carbonate salt such as sodium carbonate.12. The method according to claim 7 , wherein the drying in step c) is to a dry ...

PROCESS FOR PRODUCING POROUS ALGINATE-BASED AEROGELS

The present invention relates to a process for preparing a porous material, at least comprising the steps of providing a mixture (I) comprising a water soluble polysaccharide, at least one compound suitable to react as cross-linker for the polysaccharide or to release a cross-linker for the polysaccharide, and water, and preparing a gel (A) comprising exposing mixture (I) to carbon dioxide at a pressure in the range of from 20 to 100 bar for a time sufficient to form a gel (A), and depressurizing the gel (A). Gel (A) subsequently is exposed to a water miscible solvent (L) to obtain a gel (B), which is dried. The invention further relates to the porous materials which can be obtained in this way and the use of the porous materials as thermal insulation material, for cosmetic applications, for biomedical applications or for pharmaceutical applications. 1. A porous material , which is obtained or obtainable by the process comprising: (i) a water soluble polysaccharide,', '(ii) a compound which reacts as a cross-linker for the polysaccharide or which releases a cross-linker for the polysaccharide, and', '(iii) water;, 'a) providing a mixture (I) comprising'} b1) exposing the mixture (I) to carbon dioxide at a pressure in a range of from 20 to 100 bar for a time sufficient to form a gel (A), and', 'b2) depressurizing the gel (A);, 'b) preparing a gel (A) by a process comprising'}c) exposing the gel (A) to a water miscible solvent (L) to obtain a gel (B); andd) drying of the gel (B).2. The porous material of claim 1 , wherein the water soluble polysaccharide is selected from the group consisting of agar claim 1 , alginate claim 1 , carrageenan claim 1 , cellulose claim 1 , hyaluronic acid claim 1 , pectin claim 1 , starch claim 1 , xanthan gum claim 1 , modified cellulose claim 1 , chitin claim 1 , chitosan claim 1 , and a mixture thereof.3. The porous material of claim 1 , wherein the water soluble polysaccharide is an alginate.4. The porous material of claim 1 , wherein ...

HIGHLY EFFICACIOUS HEMOSTATIC ADHESIVE POLYMER SCAFFOLD

The invention relates to biocompatible polymer gel compositions useful in facilitating and maintaining hemostasis. The biocompatible polymeric gel composition is comprised of (a) one or more than one polyanionic polymer, (b) one or more than one polycationic polymer, and (c) a solvent. A preferred composition includes sodium alginate, chitosan, and water to produce an adhesive hemostatic device that is useful in facilitating and maintaining rapid hemostasis. 1110-. (canceled)112. The polymeric composition of claim 111 , wherein the composition exhibits hemostatic efficacy in vitro in less than about 30 seconds upon introduction to blood.113. The polymeric composition of claim 111 , wherein said chitosan has an average degree of deacetylation of between about 80.0% to about 99.0%.114. The polymeric composition of claim 111 , having a density of between about 1.10 g/mL and about 1.30 g/mL at about 25° C.115. The polymeric composition of claim 111 , wherein about 13 mg or more of said composition coagulates about 0.34 mL of blood in vitro.116. The polymeric composition of claim 111 , having a modulus of elasticity of about 16 kPa.117. A method of making a polymeric composition of claim 111 , comprising:a. mixing sodium alginate with water to dissolve the sodium alginate to form a solution, andb. dispersing solid particles of chitosan having an average degree of deacetylation between about 75% to about 99.0% to the solution of sodium alginate to form the polymeric composition.118. The polymeric composition of claim 111 , comprising:a. about 2% to about 5% by weight of sodium alginate;b. about 10% to about 30% by weight of chitosan; andc. about 60% to about 88% by weight water.119. The polymeric composition of claim 118 , comprising:a. about 3% to about 5% by weight of sodium alginate;b. about 10% to about 25% by weight of chitosan; andc. about 60% to about 88% by weight water.120. The polymeric composition of claim 119 , comprising:a. about 3% to about 5% by weight of ...

Alginate gum

The present invention relates to an alginate gum, a method for formation of an alginate gum, optionally in particulate form, and methods of use and the use thereof for example in cheese production.

Hydrogels Based On Functionalized Polysaccharides

The present invention relates to functionalized hydrogel networks grafted with at least one moiety for use in numerous fields, from cosmetics to surgery and medicine.

METHODS OF FORMING IONICALLY CROSS-LINKED GELS

The present invention relates to the formation of gels. In particular, the present invention is directed to a method of forming a cross-linked polymer hydrogel using competitive ligand exchange. 1. A method of forming a cross-linked polymer gel comprising mixing a first solution and a second solution , wherein the first solution comprises a crosslinking agent and a first chelating agent; the second solution comprises a displacing agent; wherein at least one of the first or second solutions contains an ionotropic polymer; and wherein:(a) the ionotropic polymer has a lower affinity for the crosslinking agent than the first chelating agent, and(b) the first chelating agent has a higher affinity for the displacing agent than the crosslinking agent.2. The method of claim 1 , wherein the second solution further comprises a second chelating agent capable of chelating the displacing agent.3. The method of claim 2 , wherein the ionotropic polymer has a lower affinity for the displacing agent than the second chelating agent.4. The method of claim 2 , wherein the second chelating agent has a lower affinity for the crosslinking agent than the ionotropic polymer.5. The method of claim 2 , wherein the ionotropic polymer has a lower affinity for the displacing agent than the second chelating agent.6. The method of claim 1 , wherein the crosslinking agent and the displacing agent are different multivalent metal ions.7. The method of claim 1 , wherein the first and second solutions contain the ionotropic polymer.8. The method of claim 1 , wherein the first and second solutions contain the same ionotropic polymer or different ionotropic polymers.9. The method of claim 1 , wherein the crosslinking agent and the displacing agent are independently selected from multivalent metal ions selected from the group consisting of Ca claim 1 , Zn claim 1 , Fe claim 1 , Fe claim 1 , Al claim 1 , VO claim 1 , Cu claim 1 , Ba claim 1 , Sr claim 1 , Ho claim 1 , Mg claim 1 , Mn claim 1 , Zn claim 1 , ...

HYDROGEL DRUG DELIVERY SYSTEMS FOR THE TREATMENT OF PEDIATRIC GROWTH PLATE INJURIES

The present invention relates to the unexpected discovery of compositions and methods for the treatment of growth plate defects. In certain embodiments, the methods prevent the growth of “bony bars” at the site of growth plate injury, thereby preventing growth arrest and/or deformity. In certain embodiments, the compositions comprise hydrogels comprising at least one biological factor capable of preventing bony bar formation. 1. A gel based composition comprising at least one hydrogel polymer material selected from the group consisting of chitosan and alginate; and at least one biological factor selected from the group consisting of anti-VEGF compounds , stem cell attracting factors , and transforming growth factor beta cytokines , wherein the gel is suitable for treatment of growth plate injuries.2. The composition of claim 1 , wherein the at least one biological factor is selected from the group consisting of SDF-1α claim 1 , CCL25 claim 1 , TGF-β1 claim 1 , TGF-β3 claim 1 , ranibizumab claim 1 , bevacizumab claim 1 , lapatinib claim 1 , sunitinib claim 1 , sorafenib claim 1 , axitinib claim 1 , and pazopanib.3. The composition of claim 1 , wherein the at least one biological factor is a monoclonal antibody raised against VEGF.4. The composition of claim 1 , which comprises a hydrogel polyelectrolyte complex (PEC) comprising chitosan and alginate claim 1 , wherein the at least one biological factor is embedded within the hydrogel PEC.5. The composition of claim 1 , which comprises a microgel comprising chitosan claim 1 , wherein the at least one biological factor is embedded within the microgel.6. The composition of claim 5 , wherein the microgel is nested within a hydrogel comprising alginate.7. The composition of claim 6 , wherein the hydrogel comprising alginate comprises at least one biological factor.8. The composition of claim 7 , wherein the at least one biological factor embedded within the microgel is different from the at least one biological factor ...

A METHOD FOR BUILDING A STRUCTURE CONTAINING LIVING CELLS

A composition comprising a first material and a second material, wherein said first material is cross-linkable by a first cross-linking reaction and said second material is cross-linkable by a second cross-linking reaction, wherein said first cross-linking reaction and said second cross-linking reaction are inducible by a common activator. 1. A composition comprising a first material and a second material , wherein said first material is cross-linkable by a first cross-linking reaction and said second material is cross-linkable by a second cross-linking reaction , wherein said first cross-linking reaction and said second cross-linking reaction are inducible by a common activator.2. A composition as claimed in claim 1 , wherein said first material is a polymer claim 1 , preferably a biopolymer or wherein said first material is a polypeptide claim 1 , a polysaccharide or a polynucleotide claim 1 , wherein preferably said first material is a polysaccharide claim 1 , preferably a polysaccharide derived from alginate.34-. (canceled)5. A composition as claimed in claim 1 , wherein said second material comprises a biocompatible synthetic or semi-synthetic polymer wherein preferably said second material comprises a hydrophilic polymer or a swellable polymer claim 1 , and wherein preferably said second material comprises a copolymer of a hydrophilic polymer and an oligopeptide claim 1 , wherein preferably said oligopeptide is or provides a substrate for said second cross-linking reaction claim 1 , and wherein preferably said oligopeptide is or provides a substrate for at least one additional reaction claim 1 , e.g. an enzymatic reaction.610-. (canceled)11. A composition as claimed in claim 1 , wherein said second material further comprises an additional biomolecule having a biological function claim 1 , preferably a signalling molecule e.g. a cell-adhesive peptide or a growth factor.12. A composition as claimed in claim 1 , wherein said second material comprises a modified ...

SPRAY DRY METHOD FOR ENCAPSULATION OF BIOLOGICAL MOIETIES AND CHEMICALS IN POLYMERS CROSS-LINKED BY MULTIVALENT IONS FOR CONTROLLED RELEASE APPLICATIONS

Microencapsulation of bioactive and chemical cargo in a stable, cross-linked polymer matrix is presented that results in small particle sizes and is easily scaled-up for industrial applications. A formulation of a salt of an acid soluble multivalent ion, an acid neutralized with a volatile base and one or more monomers that cross-link in the presence of multivalent ions is atomized into droplets. Cross-linking is achieved upon atomization where the volatile base is vaporized resulting in a reduction of the pH of the formulation and the temporal release of multivalent ions from the salt that cross-link the monomers forming a capsule. The incorporation of additional polymers or hydrophobic compounds in the formulation allows control of hydration properties of the particles to control the release of the encapsulated compounds. The operational parameters can also be controlled to affect capsule properties such as particle-size and particle-size distribution. 1. A method of cross-linking polymer molecules , comprising:(a) mixing monomer molecules, at least one salt of an acid soluble multivalent ion and an acid neutralized with a volatile base; and(b) volatilizing said volatile base, thereby liberating said multivalent ions and initiating cross-linking of the monomer molecules.2. A method as recited in claim 1 , wherein said monomer is selected from the group of monomers consisting of alginates claim 1 , polygalacturonates claim 1 , chitosan claim 1 , collagen claim 1 , latex claim 1 , soy proteins and whey proteins.3. A method as recited in claim 1 , wherein said multivalent ion is a divalent cation.4. A method as recited in claim 3 , wherein said divalent cation is selected from the group of cations consisting of barium (Ba) claim 3 , calcium (Ca) claim 3 , chromium (Cr) claim 3 , copper (Cu) claim 3 , iron (Fe) claim 3 , magnesium (Mg) and zinc (Zn).5. A method as recited in claim 1 , wherein said acid is an organic acid selected from the group of acids consisting of ...

BIOCOMPATIBLE NANOPARTICLE AND USE THEREOF

The present invention relates to a biocompatible nanoparticle and a use thereof and, more specifically, to a biocompatible nanoparticle formed by irradiation an electron beam to an aqueous solution comprising at least one substance selected from the group consisting of a polysaccharide, a derivative thereof and a polyethylene glycol, thereby inducing inter-molecular cross-linking or intra-molecular cross-linking, and to a use of the biocompatible nanoparticle in a drug carrier, a contrast agent, a diagnostic agent or an intestinal adhesion prevention agent or for disease prevention and treatment. 1. A biocompatible nanoparticle formed exclusively by inter-molecular crosslinking or intra-molecular crosslinking of at least one selected from the group consisting of a polysaccharide , a derivative thereof , and polyethylene glycol.2. The nanoparticle of claim 1 , wherein the biocompatible nanoparticle is formed exclusively by inter-molecular or intra-molecular crosslinking of a polysaccharide or a derivative thereof.3. The nanoparticle of claim 1 , wherein the biocompatible nanoparticle is formed exclusively by inter-molecular crosslinking of polyethylene glycol and a polysaccharide or a derivative thereof.4. The nanoparticle of claim 1 , wherein the polysaccharide is at least one selected from the group consisting of chitosan claim 1 , gelatin claim 1 , collagen claim 1 , mannan claim 1 , dextran sulfate claim 1 , α-cyclodextrin claim 1 , β-cyclodextrin claim 1 , γ-cyclodextrin claim 1 , fructo-oligosaccharides claim 1 , isomalto-oligosaccharides claim 1 , inulin claim 1 , hyaluronic acid claim 1 , alginate claim 1 , glycogen claim 1 , amylose claim 1 , carboxymethyl dextran claim 1 , beta-glucan claim 1 , hydroxyethyl cellulose claim 1 , carboxymethyl cellulose claim 1 , fucoidan claim 1 , and chondroitin.5. The nanoparticle of claim 1 , wherein the nanoparticle is prepared by a method comprising: (a) adding claim 1 , to water claim 1 , at least one material selected ...

Highly-swellable polymeric films and compositions comprising the same

Highly-swellable polymeric films are provided. Aspects also include ingestible compositions that include the highly-swellable polymeric film and an ingestible component. Aspects further include methods of making and using the compositions.

一种可注射水凝胶及其制备方法

本发明涉及一种可注射水凝胶。该可注射水凝胶含有链状或交联聚赖氨酸单元和链状或交联改性多糖单元，其无毒、且具有理想的交联强度、力学性能，以及较好流动性和天然抑菌防腐性能，可以在医用止血材料、医用敷料、泪小管栓子治疗干眼症方面获得广泛的应用；本发明还涉及上述可注射水凝胶的制备方法。该方法使用聚赖氨酸和改性多糖作为交联底物，较少使用有机化学试剂，制备过程安全环保。

Hydrogel with controllable biodegradation behavior and the manufacturing method thereof

PURPOSE: A hydrogel is provided to be used for an operation regardless of the formed shape of a bone, to control a body decomposition rate, and to be degradable after osteogenesis. CONSTITUTION: A hydrogel comprises PEG(polyethylene glycol) which has a polymerization group; an IPN(interpentetrating polymer network) which is capable of being penetrated and comprising photopolymerized PEG; natural polymer additives which have a higher viscosity level and a body decomposition rate which can increase a body decomposition rate; and photopolymerization initiator which has radicals for initiating the PEG. The natural polymer additives comprise at least one selected from carboxy methyl cellulose, heparin sulfate, hyaluronic acid, collage, chitosan, dextran, and alginate.

Hydrogel and preparation method thereof

本发明涉及一种水凝胶及其制备方法以及用于皮下填充剂或药物载体或细胞支架的生物医学用途。步骤如下：首先将藻酸钠溶于缓冲液中，配制成胶溶液，装于注射器中，将交联剂装于另一注射器中，并将所述两支注射器链接在一起；然后将所述两支注射器来回推动，使得所述胶溶液与所述交联剂混合均匀，然后注射，注射后完成交联反应，得到所述水凝胶。本发明的方法使得交联注射一体化，无需反应之后的消毒，避免了消毒过程给产品性能造成的影响。

Wellbore Servicing Fluid Compositions and Use Thereof

A method of servicing a wellbore in contact with a subterranean formation comprising placing a wellbore servicing fluid comprising a polyuronide polymer within the wellbore, contacting the wellbore servicing fluid with a divalent ion source, and allowing the wellbore servicing fluid to form a gel within the wellbore wherein the divalent ion source is located within the wellbore. A method of servicing a wellbore in contact with a subterranean formation comprising (a) placing a wellbore servicing fluid comprising a polyuronide polymer into the wellbore wherein the wellbore servicing fluid contacts a calcium ion source, (b) shutting the wellbore and allowing the servicing fluid to set into place for a period of time, and (c) repeating steps (a) and (b) until the permeability of a structure within the wellbore is reduced by about 50%.

Wellbore servicing fluid compositions and use thereof

A method of servicing a wellbore in contact with a subterranean formation comprising placing a wellbore servicing fluid comprising a polyuronide polymer within the wellbore, contacting the wellbore servicing fluid with a divalent ion source, and allowing the wellbore servicing fluid to form a gel within the wellbore wherein the divalent ion source is located within the wellbore. A method of servicing a wellbore in contact with a subterranean formation comprising (a) placing a wellbore servicing fluid comprising a polyuronide polymer into the wellbore wherein the wellbore servicing fluid contacts a calcium ion source, (b) shutting the wellbore and allowing the servicing fluid to set into place for a period of time, and (c) repeating steps (a) and (b) until the permeability of a structure within the wellbore is reduced by about 50%.

Controllable slow-release green gel based on alkyl polyglucoside and preparation method and application thereof

本发明涉及一种基于烷基聚葡糖苷的可控缓释绿色凝胶及其制备方法与应用，所述的凝胶以天然高分子多糖衍生物为骨架，天然高分子多糖衍生物的网格中包覆有APG微乳液，所述的天然高分子多糖衍生物是天然高分子材料在氢离子释放剂和钙源作用下进行原位释放交联得到的，所述的APG微乳液包括油相、水相和表面活性剂。本发明通过在凝胶体系中搭载特定微乳液，并将疏水药物增溶在微乳液中，避免疏水性药物不易搭载的缺点；使用能够完全降解的绿色表面活性剂构建微乳液，既能增加体系的载药量，也增加了环境友好性和生物兼容性。所形成的凝胶体系，通过调整原料配比，可实现药物在可控周期的缓释。

A kind of isobutyiene-maieic anhydride alternate copolymer/Sodium Alginate Hydrogel Films and preparation method thereof

本发明涉及一种异丁烯/马来酸酐交替共聚物/海藻酸钠水凝胶及其制备方法。所述水凝胶由海藻酸钠，固化剂，缓凝剂，交联剂，防腐剂，余量为水组成。本发明所得水凝胶，胶体性能稳定，耐温性能好，60度高温稳定性好，‑20度低温均不析水，制备工艺简单，条件温和，是一种性能优越的载体，可用于空气清新剂，面膜等日化领域。

Composite membrane and preparation method thereof

本发明提供一种复合膜及其制备方法，该复合膜含有海藻酸钠、明胶、氧化石墨烯。SA‑GE‑GO复合膜可作为一种生物可降解复合膜，在食品外包装领域有较高的潜在应用价值。

Dendritic macroporous hydrogels prepared by crystal templating

The present invention includes a hydrogel and a method of making a porous hydrogel by preparing an aqueous mixture of an uncrosslinked polymer and a crystallizable molecule; casting the mixture into a vessel; allowing the cast mixture to dry to form an amorphous hydrogel film; seeding the cast mixture with a seed crystal of the crystallizable molecule; growing the crystallizable molecule into a crystal structure within the uncrosslinked polymer; crosslinking the polymer around the crystal structure under conditions in which the crystal structure within the crosslinked polymer is maintained; and dissolving the crystals within the crosslinked polymer to form the porous hydrogel.

HYDROGEL, MANUFACTURE MATHOD THEREOF, AND pH SENSOR USING THE SAME

The present invention relates to a hydrogel, a manufacturing method thereof, and a pH sensor including the same and, more specifically, to a hydrogel for reversibly expressing a unique color with respect to the pH value of a specimen capable of reusing in place of the conventional pH test strips, and to a pH sensor using the same. The hydrogel of the present invention is manufactured as a gel type to be widely measured without limitation of the specimen and is capable of being applied or coated on various places. In addition, the hydrogel of the present invention can be repeatedly and continuously used through reversible color change depending on the acidity or alkalinity of the specimen.

Highly-swellable polymeric films and compositions comprising the same

Highly-swellable polymeric films are provided. Aspects also include ingestible compositions that include the highly-swellable polymeric film and an ingestible component. Aspects further include methods of making and using the compositions.

Preparation method of aldehyde hydrazine cross-linked antibacterial hydrogel dressing

本发明提供一种醛肼交联型抗菌水凝胶敷料的制备方法，包括以下步骤：（1）将海藻酸钠水溶液、羟基苯并三唑一水合物HOBT、CDH、1‑(3‑二甲氨基丙基)‑3‑乙基碳二亚胺盐酸盐EDC制得AL‑CDH；（2）将步骤（1）所得AL‑CDH、超纯水、茶多酚制得水凝胶前体A；（3）将海藻酸钠水溶液、羟基苯并三唑一水合物HOBT、3‑氨基‑1，2‑丙二醇APD、1‑(3‑二甲氨基丙基)‑3‑乙基碳二亚胺盐酸盐EDC制得到AL‑APD；（4）将步骤（3）所得AL‑APD、高碘酸钠水溶液、乙酸制得水凝胶前体B；（5）将步骤（2）所得水凝胶前体A、步骤（4）所得水凝胶前体B混合均匀得到醛肼交联型抗菌水凝胶敷料。本发明制备得到的醛肼交联型抗菌水凝胶敷料能在室温下快速成胶、有效抑制细菌的增殖，具有良好的生物相容性。

High-strength fluorescent hydrogel and preparation method thereof

本发明提供一种高强度荧光水凝胶及其制备方法，将丙烯酰胺、交联剂、引发剂溶于水后，加入碳量子点水溶液，即得溶液A；将海藻酸钠加入去离子水中，微热至完全溶解，即得溶液B；溶液A和溶液B按质量比1~6:4~9注入模具中，聚合；聚丙烯酰胺/海藻酸钠/碳量子点半互穿网络型水凝胶于氯化钙水溶液中浸泡，从而得到高强度荧光水凝胶，本发明采用碳量子点作为荧光物质，碳量子点表面大量的羟基和氨基能够与聚丙烯酰胺/海藻酸钠复合水凝胶之间形成氢键，增加了物理交联，该水凝胶不仅具有高强度，能同时抗拉伸和压缩，而且具有优异荧光示踪功能，可以用于实时跟踪研究植入水凝胶在体内的迁移变化，因此拓展了传统水凝胶的在生物医用领域的应用范围。

Hydrogel membrane for adhesion prevention

생체적합성 막은 알기네이트 및 히알루로네이트로 구성된다. 막은 수술 후에 원치 않는 반흔형성을 방지하기 위해 사용될 수 있다. 막의 조직 접착성 및 생체재흡수 속도는 격리제 및 점도 개질제를 포함하는 외부 자극제를 통해 변경될 수 있다. Biocompatible membranes consist of alginate and hyaluronate. Membranes can be used to prevent unwanted scar formation after surgery. The tissue adherence and bioresorption rate of the membrane may be altered through external stimulants including quenchers and viscosity modifiers.

Double-crosslinking integrated seamless composite hydrogel support for articular cartilage repair

本发明涉及组织工程关节软骨修复技术领域，具体是一种用于关节软骨修复的双交联一体化无缝复合水凝胶支架。由下至上依次为软骨下骨层、钙化界面层和软骨层；软骨下骨层为含有生物陶瓷颗粒与海藻酸盐的水凝胶；钙化界面层为含有海藻酸盐和聚阳离子的聚电解质静电络合水凝胶；软骨层为含有海藻酸盐的水凝胶；所述软骨下骨层、钙化界面层和软骨层中的海藻酸盐水凝胶先形成离子交联水凝胶，再通过共价交联形成双交联一体化无缝结构。本发明的双交联一体化水凝胶支架力学强度显著优于离子交联的水凝胶支架，界面结合力提高，凝胶支架中间的聚电解质复合水凝胶膜层，实现了对软骨和软骨下骨微环境的隔离效应。

3D cell culture medium and preparation method thereof

本发明公开了一种3D细胞培养基质及其制备方法，将氧化海藻酸与海藻酸钠按比例混合，并用蒸馏水配置成混合海藻酸钠溶液；在无菌环境下过滤，随后依次加入浓缩培养基、血清/生长因子混匀，得培养溶液；最后与无菌氯化钙溶液混合交联，即得3D细胞培养基质。采用本发明制得的3D细胞培养基质解决了海藻酸钠溶液难以有效除菌，而氧化海藻酸钠因氧化度过高而交联度过低的问题。同时通过调整海藻酸钠与氧化海藻酸钠的配比提升了培养基质的可塑性，更适于细胞的增殖生长。若需培养细胞，即把所需培养的细胞按一定接种浓度加入培养溶液中，轻柔混匀，最后再与无菌氯化钙交联，即可培养细胞。

Immune cell trapping devices and methods for making and using the same

Embodiments herein described provide devices for identifying and collecting rare cells or cells which occur at low frequency in the body of a subject, such as, antigen-specific cells or disease-specific cells. More specifically, the devices are useful for trapping immune cells and the devices contain a physiologically-compatible porous polymer scaffold, a plurality of antigens, and an immune cell-recruiting agent, wherein the plurality of antigens and the immune cell recruiting agent attract and trap the immune cell in the device. Also provided are pharmaceutical compositions, kits, and packages containing such devices. Additional embodiments relate to methods for making the devices, compositions, and kits/packages. Further embodiments relate to methods for using the devices, compositions, and/or kits in the diagnosis or therapy of diseases such as autoimmune diseases or cancers.

Polymer composition

本发明涉及新的高体积溶胀水凝胶，其包括多个孔，所述孔由任选地与一种或多种生物相容性聚合物在一起的、以及任选地与一种或多种增塑剂在一起的、众多一种或多种亲水聚合物的互穿网络和/或半互穿网络和/或简单的交联排列限定，其特征在于，至少一些孔至少部分地塌陷和/或变平，并且进一步的特征在于，限定塌陷和/或变平的孔的互穿网络和/或半互穿网络和/或交联排列基本上是未破坏的。本发明还涉及用于制备这种水凝胶的方法，以及它们作为食欲抑制剂的用途。

A kind of preparation method and applications of hydrogel, hydrogel

本发明涉及一种水凝胶的制备方法，其包括如下步骤：制备水溶液：将水与辅料混合形成水溶液；制备悬浊液：将碱土金属盐与所述水溶液混合形成悬浊液，并使30‑50％的碱土金属盐溶解于所述水溶液中；制备水凝胶：将所述悬浊液与海藻酸盐水溶液均匀混合形成水凝胶。本发明还涉及一种用该制备方法制备的水凝胶及其应用方法。

Edible molded bodies, especially flat and flexible tubular films

Die Erfindung betrifft eßbare Formkörper in Gestalt einer Flach- oder Schlauchfolie auf der Basis von plastifizierbaren Biopolymeren, seinen Spaltprodukten oder Derivaten und/oder synthetischen Polymeren aus natürlichen Monomeren, die dadurch gekennzeichnet sind, daß man sie nach einem Verfahren mit den folgenden Stufen herstellt: a) Vermischen der Biopolymere, seiner Spaltprodukte oder Derivate und/oder der synthetischen Polymere mit mindestens einem eßbaren Weichmacher, mindestens einem Gleitmittel und mindestens einem Vernetzungsmittel, b) Aufschmelzen des so erhaltenen Gemisches zu einer thermoplastichen Masse, c) Extrudieren dieser Masse und d) Kalandrieren und/oder Verstrecken oder Blasverformen des bei der Extrusion erhaltenen Produkts zu dem eßbaren Formkörper. Die erfindungsgemäßen Formkörper eignen sich zum Verpacken von Nahrungsmitteln, wie Wurst und Kochschinken. Insbesondere eignen sie sich als nahtlose Wursthüllen.

Edible molded bodies, especially flat and flexible tubular films

The invention relates to edible molded bodies in the form of a flat or tubular film based on plastifiable biopolymers, the cleavage products or derivatives thereof and/or synthetic polymers from natural monomers, characterized in that they are produced according to a method comprising the following steps: a) the biopolymers, cleavage products or derivatives thereof and/or synthetic polymers are mixed with at least one edible plasticizer, at least one lubricating agent and at least one cross-linking agent, b) the mixture thus obtained is melted into a thermoplastic material, c) said material is extruded and d) the product obtained by extrusion is calendered and/or stretched or blown and deformed into the edible molded body. The molded bodies cited in the invention are suitable for use as food wrappers for sausages and boiled ham, and are particularly suitable for use as seamless sausage casings.

A kind of hydrogel and preparation method and application with micro-current and medicament slow release effect

本发明公开了一种具有微电流和药物缓释作用的水凝胶及制备方法与应用。本发明通过将药物和碳量子点反应，得到载药碳量子点；将海藻酸钠溶液、羧甲基纤维素钠溶液、发电物质、载药碳量子点和无水碳酸钙粉末混匀，得到混合液A；往混合液A中加入葡萄糖内酯，搅拌均匀，超声脱泡、流平、干燥，得到具有微电流和药物缓释作用的水凝胶。该水凝胶具有如下优点：优异的力学性能；很好的药物缓释性能；很好的促愈合效果；很好的溶胀性能；以及很好生物安全性，市场应用潜力大。

Highly-swellable polymeric films and compositions comprising the same

Highly-swellable polymeric films are provided. Aspects also include ingestible compositions that include the highly-swellable polymeric film and an ingestible component. Aspects further include methods of making and using the compositions.

A kind of high-adhesiveness aerogel dressing and preparation method thereof

本发明提供了一种高粘附性水凝胶敷料及其制备方法，包括以下步骤：（1）制备壳聚糖溶液；（2）制备海藻酸钙水溶液；（3）将明胶以用碳二亚胺和N‑羟基琥珀酰亚胺进行修饰，然后加入壳聚糖溶液、海藻酸钙水溶液反应，反应液透析浓缩后制得混合物A；（4）向混合物A中加入丙三醇、聚乙烯醇、聚乙二醇和聚乙烯吡咯烷酮，继续搅拌混合得到混合物B；（5）在搅拌的条件下向混合物B中加入光引发剂、银纳米粒子、氯化钙溶液，浇注至模具中，再在紫外光下辐照即制得促愈合水凝胶敷料。本发明制得的水凝胶具有良好的粘附性、高机械强度和优良的生物相容性。因此，其具有良好的应用前景。

Aerogels loaded with active materials and hydrogel and aerogel composites

提供一种载有活性材料的气凝胶，以及水凝胶和气凝胶的复合物。根据本发明的复合物的制备方法包括以下步骤：制备在孔中具有活性材料的多个气凝胶颗粒；制备将聚合物溶解在水溶性溶剂中的聚合物溶液；在将气凝胶颗粒混合到所述聚合物溶液中之后，通过均质化来制备气凝胶/聚合物分散体，并通过将所述分散体与交联剂溶液混合来制备气凝胶/水凝胶复合载体。根据本发明，通过制备其中分散有多个气凝胶颗粒的水凝胶复合物，可以提供其中可以同时载有油和水分而没有任何表面活性剂的复合载体。此外，可以制备具有改善的性质，例如低密度、高强度、高组分含量和稳定解吸的复合载体。

Preparation method of abalone shell powder/ZnO composite material-doped intelligent hydrogel wound dressing with antibacterial effect

本发明属于医用材料技术领域，涉及一种具有抑菌作用的鲍鱼壳粉/ZnO复合材料掺杂的智能水凝胶伤口敷料的制备方法。根据材料的界面与物相作用，利用材料制备的技术和方法，将鲍鱼壳粉/ZnO复合材料、壳聚糖粉末与海藻酸钠溶液形成均匀浆液，选用葡萄糖酸内酯作为质子供体，原位制备出具有抑菌作用的鲍鱼壳粉/ZnO复合材料掺杂的纯物理交联壳聚糖/海藻酸钠双网络智能水凝胶敷料。选用的材料其生物相容性好、无细胞毒性，该敷料可抑制细菌感染，促进创面愈合。

Method for preparing porous scaffold for tissue engineering, cell culture and cell delivery

本发明涉及一种用于组织工程的多孔支架的制备方法。本发明的另一个目的是提供一种由上述方法获得的多孔支架，及其在组织工程、细胞培养和细胞输送中的应用。本发明的方法包括以下步骤：a)制备碱性水性溶液，其含有一定量的至少一种多糖和一种交联剂，以及一定量的致孔剂；b)将所述溶液在约4℃-约80℃下放置足够的时间，使得所述一定量的多糖交联，从而将溶液转化为水凝胶；c)将所述水凝胶浸没于水性溶液中；d)洗涤步骤c)得到的多孔支架。

PROCESS FOR PREPARING BIOCOMPATIBLE POLYMERIC AND BIODEGRADABLE THREE-DIMENSIONAL MATRICES AND APPLICATIONS

La présente invention est relative à un procédé de préparation d'une matrice polymère tridimensionnelle poreuse biocompatible et biodégradable, à la matrice polymère poreuse obtenue par un tel procédé, ainsi qu'à ses utilisations, notamment comme support et pour la culture de cellules ou en médecine régénérative, et notamment pour la thérapie cellulaire, en particulier cardiaque. The present invention relates to a process for preparing a biocompatible and biodegradable porous three-dimensional polymer matrix, to the porous polymer matrix obtained by such a method, as well as to its uses, in particular as a support and for cell culture or in regenerative medicine, and in particular for cell therapy, in particular cardiac therapy.

Alginate water treatment agent containing activated carbon and method for producing the same

본 발명의 활성탄-알긴산겔 수처리제는 알긴산염과 분말활성탄의 수용액을 다가 양이온 용액에 적하하여 활성탄과 알긴산을 가교 결합시켜, 활성탄-알긴산겔을 제조하고, 이 활성탄-알긴산겔을 건조시켜 활성탄-알긴산겔 수처리제를 제조한다. 알긴산염과 분말활성탄의 수용액은 알긴산염이 0.1~5중량%, 분말활성탄이 0.5~10중량%인 것이 바람직하다. 다가 양이온 용액으로는 CaCl 2 , SrCl 2 , BaCl 2 및 AlCl 3 가 있다. 상기 방법에 따라 활성탄-알긴산겔 수처리제는 그 표면을 알긴산겔로 코팅하여, 수처리제로부터 활성탄이 방출되어 나오는 것을 방지할 수 있고 중금속의 흡착효율을 높일 수 있다. 상기의 수처리제를 알긴산겔로 코팅하는 방법은 0.1~2.0중량%의 알긴산염 용액에 수처리제표면을 적셔준 후 이를 꺼내서 다시 다가 양이온 용액에 넣어 알긴산겔을 코팅하는 것이다. The activated carbon-alginic acid gel water treatment agent of the present invention is added dropwise an aqueous solution of alginate and powdered activated carbon to a polyvalent cation solution to crosslink the activated carbon and alginic acid to prepare an activated carbon-alginic acid gel, and the activated carbon-alginic acid gel is dried to activate activated carbon-alginic acid. Prepare a gel water treatment. The aqueous solution of alginate and powdered activated carbon is preferably 0.1 to 5% by weight of alginate and 0.5 to 10% by weight of powdered activated carbon. Polyvalent cation solutions include CaCl 2 , SrCl 2 , BaCl 2 and AlCl 3 . According to the above method, the activated carbon-alginate gel water treatment agent may coat the surface with the alginate gel, thereby preventing the activated carbon from being released from the water treatment agent and increasing the adsorption efficiency of heavy metals. The method of coating the water treatment agent with an alginate gel is to wet the surface of the water treatment agent in an alginate solution of 0.1 to 2.0% by weight, take it out, and put it back into the polyvalent cation solution to coat the alginate gel.

Biocompatible nanoparticle and use thereof

본 발명은 생체적합성 나노입자 및 이의 용도에 관한 것으로, 보다 상세하게는 다당(polysaccharide), 이의 유도체 및 폴리에틸렌글리콜로 이루어진 군에서 선택된 어느 하나 이상의 물질 수용액에 전자빔을 조사하여 분자 간 가교결합(inter-molecular cross-linking) 또는 분자 내 가교결합(intra-molecular cross-linking)을 유도하여 형성된 생체적합성 나노입자 및 이의 약물 전달체, 조영제, 진단제, 장유착방지제 또는 질병의 예방 및 치료용도에 관한 발명이다. 본 발명의 생체적합성 나노입자는 유기용매 또는 가교제의 혼입에 따른 인체 내 독성문제가 발생할 염려가 전혀 없고, 그 제조과정 중 별도의 정제과정이 필요치 않아 짧은 시간의 전자빔 조사만으로 대량 생산이 가능하여 생산성 측면에서도 매우 우수하다. 또한, 본 발명의 나노입자는 약물전달체, 약학적 조성물, 조영제 조성물, 장유착방지제 등 다방면으로 활용될 수 있다는 점에서 매우 유용하다. The present invention relates to a biocompatible nanoparticle and its use, and more particularly, to a biocompatible nanoparticle, and more particularly, to a biocompatible nanoparticle, and more particularly to a biocompatible nanoparticle, The present invention relates to a biocompatible nanoparticle formed by inducing molecular cross-linking or intra-molecular cross-linking, and its use for the prevention and treatment of drug delivery, contrast agent, diagnostic agent, . The biocompatible nanoparticles of the present invention are free from toxicity problems due to the incorporation of an organic solvent or a crosslinking agent and do not require a separate purification process during the production process, It is also excellent on the side. In addition, the nanoparticles of the present invention are very useful in that they can be utilized in various fields such as drug delivery systems, pharmaceutical compositions, contrast agent compositions, and intestinal adhesion inhibitors.

Polymer compositions

The invention relates to novel a high-volume swelling hydrogel which comprises a plurality of pores which are defined by an interpenetrating network, and/or a semi-interpenetrating network and/or simple cross-linked arrangement of a plurality of one or more species of hydrophilic polymers, optionally together with one or more biocompatible polymers and optionally together with one or more plasticising agents, characterised in that at least some of the pores are at least partially collapsed and/or flattened, and further characterised in that the interpenetrating network and/or semi-interpenetrating network and/or cross-linked arrangement which defines the collapsed and/or flattened pores is substantially unbroken. The invention also relates to a process for preparing such hydrogels, and to their use as an appetite suppressant.

Amphiphilic alginic acid particles and method for producing same

提供以来自天然的成分作为原料的、在保持适度的吸水量的同时具有疏水性的聚合物粒子。双亲媒性海藻酸粒子群，其是使用疏水剂对海藻酸多价金属盐进行疏水化处理而成的双亲媒性海藻酸粒子群，其中，通过使上述海藻酸多价金属盐的一部分的金属离子与上述疏水剂进行化学键合以进行疏水化而形成，水滴落在该粒子群时的30秒后的接触角为30°以上且150°以下，每100g粒子的吸水量为每100g粒子的吸油量以上。

Porous gels and methods for their preparation

Degradable melanin ultraviolet-proof heat-preservation transparent film and preparation method thereof

本发明公开了一种可降解的黑色素防紫外线保温透明薄膜及其制备方法。所述薄膜包括水溶性多糖粉末0.5‑3%、水溶性高分子粉末0.055‑2%、黑色素纳米颗粒0.1‑5%、增塑剂0.08‑1.75%、适量水。该保温膜的制备方法包括：A：黑色素纳米颗粒的提取和B：可降解黑色素防紫外线保温膜的制备。黑色素纳米颗粒通过分级离心提取，工艺中无化学添加剂，属于完全绿色的生物质纳米颗粒，能够有效的增强薄膜的机械性能；同时黑色素纳米颗粒优异的光热转换和防紫外线性能能够有效的吸收光能，提升薄膜的保温效果。本发明中选用材料均为绿色可降解材料，制备过程中无化学添加剂，能够实现保温膜使用后完全降解，经济绿色。

Hydrogel with microcurrent and medicine slow-release function and preparation method and application

本发明公开了一种具有微电流和药物缓释作用的水凝胶及制备方法与应用。本发明通过将药物和碳量子点反应，得到载药碳量子点；将海藻酸钠溶液、羧甲基纤维素钠溶液、发电物质、载药碳量子点和无水碳酸钙粉末混匀，得到混合液A；往混合液A中加入葡萄糖内酯，搅拌均匀，超声脱泡、流平、干燥，得到具有微电流和药物缓释作用的水凝胶。该水凝胶具有如下优点：优异的力学性能；很好的药物缓释性能；很好的促愈合效果；很好的溶胀性能；以及很好生物安全性，市场应用潜力大。