27-03-2014 дата публикации
Номер: US20140087445A1
Ligand functionalized substrates, methods of making ligand functionalized substrates, and methods of using functionalized substrates are disclosed. 2. The ligand-functional substrate of wherein said crosslinking monomers (c) have two or more free-radically polymerizable groups.3. The method of wherein said crosslinking monomer c) is of the formula:{'br': None, 'sub': 2', 'a', 'b, 'sup': 1', '10, '[CH═CH—C(O)—X]—R-Q-Z,'}where Z is an acryloyl or non-acryloyl, ethylenically unsaturated polymerizable group,{'sup': 1', '3', '3, 'sub': 1', '4, 'Xis —O— or —NR, where Ris H or C-Calkyl,'}{'sup': '1', 'sub': '2', 'Q is a divalent linking group selected from a covalent bond “—”, —O—, —NR—, —CO— and'}{'sup': 1', '1, 'sub': 1', '4, '—CONR—, where Ris H or C-Calkyl; and'}{'sup': '10', 'Ris an alkylene group of valence a+b, and optionally containing one or more catenary oxygen atoms and/or one or more hydroxyl groups;'}and a and b are each at least one.4. The ligand-functional substrate of wherein the crosslinking monomer c) comprises a poly(alkylene oxide) compound having at least one acryloyl group and at least one additional ethylenically unsaturated claim 2 , free-radically polymerizable group.5. The ligand-functional substrate of claim 2 , wherein the monomer c) is of the formula:{'br': None, 'sup': '1', 'sub': 2', 'n', '2, 'Z-Q-(CH(R)—CH—O)—C(O)—CH═CH,'}wherein Z is an acryloyl or non-acryloyl, polymerizable ethylenically unsaturated group,{'sup': 1', '1', '1', '1, 'sub': 1', '4', '2', '1', '4, 'Ris a H or a Cto Calkyl group, and n is from 2 to 100, preferably 5 to 20, and Q is a divalent linking group selected from a covalent bond “—”, —O—, —NR—, —CO— and —CONR—, where Ris H or C-Calkyl.'}6. The ligand-functional substrate of further comprising one or more additional monomers having a free-radically polymerizable group and a hydrophilic group.7. The ligand functionalized substrate of wherein said hydrophilic monomers are of the formula:{'br': None, 'sub': 2', '2', 'n, ' ...
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