19-12-2013 дата публикации
Номер: US20130338094A1
The present disclosure relates to compounds of formula (I-A) using the compounds 2. The compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , characterized by one or more of the following features:(a) X is —O—;{'sub': '2', '(b) Y is —O— or —CH—;'}{'sup': '3a', '(c) Ris —OH;'}{'sup': 3b', '3, 'sub': '1-4', '(d) Rand Rare each independently hydrogen or Caliphatic;'}{'sup': 3', '5, '(e) Ris hydrogen, fluoro, or —OR;'}{'sup': 5', '5′, '(f) Rand Rare each hydrogen;'}{'sup': '4', '(g) each Ris hydrogen;'}{'sup': '2', '(h) each Ris hydrogen;'}{'sup': 'h', '(i) Ris hydrogen;'}{'sup': 'j', '(j) Ris hydrogen; and'}{'sup': 'k', 'sub': '1-4', '(k) Ris hydrogen, halo, or Caliphatic.'}4. The compound of claim 3 , or a pharmaceutically acceptable salt thereof claim 3 , characterized by one or more of the features (a) through (f):{'sup': '3a', 'sub': 1-4', '1-4, '(a) Ris hydrogen, hydroxy, methoxy, Caliphatic, Cfluoroaliphatic, or fluoro;'}{'sup': '3', '(b) Ris hydrogen;'}{'sup': '3', '(c) Ris hydrogen or hydroxy;'}{'sup': '3d', '(d) Ris hydrogen;'}{'sup': '4', '(e) each Ris hydrogen; and'}{'sup': '5', '(f) Ris hydrogen.'}9. The compound of claim 8 , or a pharmaceutically acceptable salt thereof claim 8 , wherein Ring B is a phenyl ring substituted with 0-2 substituents independently selected from the group halo claim 8 , —OH claim 8 , —O(Calkyl) claim 8 , —CN claim 8 , —N(R) claim 8 , —C(O)(Calkyl) claim 8 , —COH claim 8 , —CO(Calkyl) claim 8 , —C(O)N H claim 8 , —C(O)NH(Calkyl) claim 8 , —Caliphatic claim 8 , —Cfluoroaliphatic claim 8 , —O(Cfluoroaliphatic) claim 8 , optionally substituted aryl claim 8 , and optionally substituted heteroaryl.10. The compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein:{'sup': 1', '12a', '12b', '12a', '12b', '12a', '12d, 'sub': '1-10', 'Ris Caliphatic, —Z—R, —Z—R, -L-Z—R, -L-Z—R, -L-Ror -L-R;'}{'sup': 13', '3, 'L is —C(R)═C(R)— or —C≡C—; and'}{'sup': 12d', '15', '15', '16', '14', '14', '16, ...
Подробнее
