30-05-2013 дата публикации
Номер: US20130137686A1
Принадлежит:
Disclosed are compounds and pharmaceutically acceptable salts of Formula I 2. A compound according to claim 1 , wherein Qis C—R.3. A compound according to claim 1 , wherein Xis N.46-. (canceled)9. A compound according to claim 8 , wherein Xis N.10. A compound according to claim 9 , wherein{'sub': 3', '4', '1', 'Z1, 'claim-text': [{'sub': '1', 'Zis —O— or —NH—;'}, {'sub': Z1', '1', '14', '22', '2, 'claim-text': {'sub': Z1', '1', '10', '1', '10', '2', '10', '2', '10', '1', '6', '2', '1', '6', '2', '2', '2', '1', '6', '2', '2', '1', '6', '2', '1', '6', '2', '10', '2', '10', '1', '10', '1', '10', '23, 'wherein Ris optionally substituted at any available position with C-Calkyl, C-Chaloalkyl, C-Calkenyl, C-Calkynyl, hydroxy, carboxy, carboxamido, oxo, halo, amino, cyano, nitro, —SH, —S—(C-C)alkyl, —SO—(C-C)alkyl, —SONH, —SONH—(C-C)alkyl, —SONH-aryl, —SO-aryl, —SO—(C-C)alkyl, —SO-aryl, C-Calkoxy, C-Calkenyloxy, C-Calkynyloxy, mono- or di-(C-C)alkylamino, —OC-Calkyl-Z, or R.'}, 'Ris a C-Calkyl group where up to five of the carbon atoms in the alkyl group are optionally replaced independently by R, carbonyl, ethenyl, ethynyl or a moiety selected from N, O, S, SO, or SO, with the proviso that two O atoms, two S atoms, or an O and S atom are not immediately adjacent each other,'}], 'Rand Rare independently hydrogen, halo, or —ZR, wherein'}11. A compound according to claim 9 , wherein{'sub': '4', 'Ris H; and'}{'sub': 3', '1', 'Z1, 'claim-text': [{'sub': '1', 'Zis —O— or —NH—;'}, {'sub': Z1', '1', '14', '22', '2, 'claim-text': {'sub': Z1', '1', '10', '1', '10', '2', '10', '2', '10', '1', '6', '2', '1', '6', '2', '2', '2', '1', '6', '2', '2', '1', '6', '2', '1', '6', '2', '10', '2', '10', '1', '10', '1', '10', '23, 'wherein Ris optionally substituted at any available position with C-Calkyl, C-Chaloalkyl, C-Calkenyl, C-Calkynyl, hydroxy, carboxy, carboxamido, oxo, halo, amino, cyano, nitro, —SH, —S—(C-C)alkyl, —SO—(C-C)alkyl, —SONH, —SONH—(C—O)alkyl, —SONH-aryl, —SO-aryl, —SO—(C-C ...
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