13-01-2022 дата публикации
Номер: US20220008619A1
Принадлежит:
The invention concerns an implant material for filling bone defects, bone regeneration and bone tissue engineering, an implant comprising this material, a method for manufacturing such an implant material. 1. An implant material for filling bone defects , bone regeneration and bone tissue engineering ,characterized in that [{'sub': 2', '2', '5, 'a bioactive glass M made from SiOand CaO, optionally containing POand/or optionally doped with strontium, and'}, the bioresorbable polysaccharides, preferably selected from dextran, hyaluronic acid, agar, chitosan, alginic acid, sodium or potassium alginate, galactomannan, carrageenan, pectin,', 'the bioresorbable polyesters, preferably polyvinyl alcohol or polylactic acid, and', 'the biodegradable synthetic polymers, preferably a polyethylene glycol, poly(caprolactone), 'a biodegradable polymer P is selected from], 'it comprises a hybrid material comprisingand in that this hybrid material is doped with an osteoinductive nutrient N selected from vitamin D2 (ergocalciferol), vitamin D3 (cholicalciferol), vitamin K1, vitamin K2, omega-3 fatty acids, punicic acid, α-lipoic acid, anthocyanins, flavonols, procyanidins, tyrosol, oleuropein, naringenin, punicalagin, ellagic acid and phycocyanin.2. The implant material for filling in bone defects claim 1 , bone regeneration and bone tissue engineering according to claim 1 , characterized in that the hybrid material doped with an osteoinductive nutrient comprises 30% by weight of bioactive glass M made from SiOand CaO claim 1 , relative to the total weight (bioactive glass M+biodegradable polymer P+osteoinductive nutrient N) claim 1 , 69% by weight of poly(caprolactone) claim 1 , relative to the total weight (bioactive glass M+biodegradable polymer P+osteoinductive nutrient N) claim 1 , and 1% by weight of fisetin and/or hydroxytyrosol claim 1 , relative to the total weight (bioactive glass M+biodegradable polymer P+osteoinductive nutrient N).3. The implant material for filling in ...
Подробнее