11-03-2021 дата публикации
Номер: US20210069692A1
Принадлежит:
Chromatography resins having anionic exchange-hydrophobic mixed mode ligands and methods of using such resins are provided. 1. A chromatography matrix covalently linked to a ligand having the following formula:{'br': None, 'sup': 1', '2, 'sub': 'n', 'Chromatography matrix-(X)—N(R)—(R-L)-Ar'}or an anionic salt thereof, X is a spacer;', {'sup': '1', 'sub': 1', '6, 'Ris hydrogen or Cto Calkyl optionally substituted with an —OH;'}, {'sup': '2', 'sub': 2', '6', '4', '6, 'Ris Cto Calkyl or Cto Ccycloalkyl;'}, {'sup': '4', 'L is NR, O, or S;'}, 'n=1 or 2; and', 'Ar is a 6-10 membered ring and:', {'sub': 1', '3', '3', '6, 'if Ar is aryl, the aryl is optionally substituted with up to five Cto Cunsubstituted alkyl, Cto Cbranched alkyl, unsubstituted aryl, or fluorine groups; or'}, 'if Ar is heteroaryl, the heteroaryl is optionally substituted with up to four unsubstituted alkyl groups,', {'sup': 1', '2', '4, 'sub': '2', 'with the proviso that when Ris hydrogen, Ris Calkyl, L is NRor O, and n is 1, Ar is not phenyl.'}], 'wherein2. The chromatography matrix of claim 1 , wherein:{'sub': 2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '3', '2, 'X is selected from the group consisting of —O—CH—, —O—CH—CH—, —O—CH—CH—CH—, —O—CH—CH—CH—CH—, —O—CH—CH(CH—OH)—(O—CH—CH(OH)—CH)—, —O—CH—CH—CH(CH—OH)—(O—CH—CH—CH(OH)—CH)—, —O—CH—CH(OH)—CH—, —O—CH—CH—CH(OH)—CH—CH—, —O—CH—CH(OH)—CH—O—CH—CH—CH—CH—O—CH—CH(OH)—CH—, and —CO—NH—C(CH)—CO—;'}{'sup': '1', 'sub': 1', '3, 'Ris hydrogen or Cto Calkyl;'}{'sup': '2', 'sub': 2', '4, 'Ris Cto Calkyl;'}L is O;n=1; and [{'sub': 1', '2', '3', '4, 'if Ar is aryl, the aryl is optionally substituted with up to four Cto Cunsubstituted alkyl, Cor Cbranched alkyl, or fluorine groups; or'}, 'if Ar is heteroaryl, the heteroaryl is optionally substituted with up to three unsubstituted alkyl groups,', {'sup': 1', '2, 'sub': '2', 'with the ...
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