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05-01-2012 дата публикации

Chroman derivatives, medicaments and use in therapy

Номер: US20120004296A1

Принадлежит: Marshall Edwards Inc

Novel chroman derivatives and intermediate compounds, compositions containing same, methods for their preparation and uses thereof as therapeutic agents particularly as anti-cancer and chemotherapeutic selective agents are described.

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Номер записи: 1

19-01-2012 дата публикации

Real-time tomosynthesis guidance for radiation therapy

Номер: US20120014501A1

Автор: Brian Patrick Wilfley, Edward Gerald Solomon, Joseph Anthony Heanue, Norbert Joseph Pelc, Rebecca Fahrig

Принадлежит: Individual

The present invention pertains to an apparatus and method for delivering radiation to a human patient or other mammal. A scanning electron beam x-ray source is used and the detector can be a photon counting detector. The area of the detector is less than the area of field of view in the patient. Tomosynthesis can be used to generate images and images can be produced rapidly in real time.

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Номер записи: 2

23-02-2012 дата публикации

Charged particle beam acceleration and extraction method and apparatus used in conjunction with a charged particle cancer therapy system

Номер: US20120043472A1

Автор: Vladimir Balakin

Принадлежит: Vladimir Balakin

The invention comprises a charged particle beam acceleration and/or extraction method and apparatus used in conjunction with charged particle beam radiation therapy of cancerous tumors. Novel design features of a synchrotron are described. Particularly, turning magnets, edge focusing magnets, and extraction elements are described that minimize the overall size of the synchrotron, provide a tightly controlled proton beam, directly reduce the size of required magnetic fields, directly reduces required operating power, and allow continual acceleration of protons in a synchrotron even during a process of extracting protons from the synchrotron.

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Номер записи: 3

23-02-2012 дата публикации

Patient positioning system and methods for diagnostic rediology and radiotherapy

Номер: US20120043475A1

Автор: Peter H. Ahn

Принадлежит: Pyronia Medical Tech Inc

The system provides new ways to ensure that a patient is positioned correctly, e.g. identically with an original planning scan if the patient is to undergo radiotherapy. The system also detects if there is patient movement during a scan. It is an aspect of the present method to immobilize the patient based on a specific site of interest by using positioning sensors that record patient physical orientation based on measurements of patient weight distribution and pressure distribution among other features.

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Номер записи: 4

23-02-2012 дата публикации

Combination therapy with parp inhibitors

Номер: US20120045524A1

Автор: Thomas D. Penning, Vincent L. Giranda, Wolfgang Wernet

Принадлежит: ABBOTT LABORATORIES

The present invention describes benzimidazole derivatives of Formula (I) which constitute potent PARP inhibitors in combination with radiotherapy or in combination with other chemotherapeutic agents.

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Номер записи: 5

01-03-2012 дата публикации

Respiration-correlated radiotherapy

Номер: US20120051515A1

Автор: Kevin Brown

Принадлежит: ELEKTA AB

An approach to radiotherapy is disclosed which allows the therapeutic beam to be more accurately directed towards a target region. Instead of stopping acquiring images during treatment, the system continues to acquire images as treatment is ongoing. This ongoing pipeline of images is used to update the previously created 3D reconstructions of each breathing phase. Thus the position of the target region can also be updated. The surrogate is recorded simultaneously with the image acquisition although it is not used to determine the breathing phase. As new images are used to update the 3D reconstructions of each breathing phase the values of the surrogate associated with that phase are also updated. This means that the correlation with the surrogate can also continue to be evaluated, and the correlation refined, thus improving the ability of the system to track the motion of the target.

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Номер записи: 6

01-03-2012 дата публикации

Method and system for radioisotope ion beam gamma therapy

Номер: US20120053389A1

Автор: Sung-Wei CHEN

Принадлежит: EMPIRE TECHNOLOGY DEVELOPMENT LLC

A method includes directing an ion beam at a tissue. Ions of the ion beam can include positron emitters. The ions can ionize at least a portion of the tissue and the positron emitters can irradiate the at least a portion of the tissue.

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Номер записи: 7

22-03-2012 дата публикации

Low-Density Magnesium-Aluminum-Silicate (MAS) Microparticles for Radiotherapy and/or Radioimaging

Номер: US20120070371A1

Автор: Delbert E. Day, Yiyong He

Принадлежит: Individual

This invention relates to low density radioactive magnesium-aluminum-silicate (MAS) microparticles that contain either samarium-yttrium, samarium, or lutetium as medical isotopes for radiotherapy and/or radioimaging.

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Номер записи: 8

29-03-2012 дата публикации

Minimally Invasive Rectal Balloon Apparatus

Номер: US20120078177A1

Автор: John ISHAM

Принадлежит: RadiaDyne LLC

A rectal balloon apparatus has a shaft with a fluid passageway extending therethrough. A balloon is affixed over an end of the shaft such that the fluid passageway communicates with an interior of the balloon. The balloon has a laterally flat surface thereon when inflated. The laterally flat surface of the balloon has a longitudinal groove formed thereon. The balloon having a pair of bulges formed thereon when the balloon is inflated. A ring is affixed to the shaft adjacent the balloon. The shaft has a plurality of holes formed thereon opening to an interior of the balloon.

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Номер записи: 9

12-04-2012 дата публикации

Brachytherapy device for facilitating asymmetrical irradiation of a body cavity

Номер: US20120088952A1

Автор: Frank R. Louw, Michael L. Jones, Paul Lubock

Принадлежит: SenoRx Inc

The disclosure describes devices and methods for asymmetrical irradiation at a body cavity or site, such as after removal of tissue, e.g. biopsy or cancer. One device includes a lumen which is off-set or off-settable from a longitudinal axis to increase the intensity of radiation received from a radiation source by a first tissue portion surrounding the body cavity and to reduce or minimize radiation received by a second tissue portion (e.g. healthy tissue) surrounding the body cavity.

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Номер записи: 10

19-04-2012 дата публикации

Apparatus and method for reducing absorption of radiation by healthy cells from an external radiation source

Номер: US20120091371A1

Автор: Harry Vartanian, Jaron Jurikson-Rhodes

Принадлежит: HJ Labs LLC

An apparatus and method for reducing absorption of radiation by healthy cells from an external radiation source provided to a living organism is disclosed. A smart device or apparatus with a smart antenna implanted near a target area in the living organism or provided externally proximate to the target area is provided to absorb any excess radiation. With the decrease of radiation or protection of healthy cells, higher radiation to the target area or diseased cells may be provided.

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Номер записи: 11

03-05-2012 дата публикации

Expandable brachytherapy apparatus and methods for using them

Номер: US20120108881A1

Автор: Eduardo Chi Sing, Tommy G. Nguyen

Принадлежит: Cianna Medical Inc

Brachytherapy treatment apparatus are provided that include an elongate core member, a plurality of expandable catheters or other elongate members and a balloon or other expandable member on a distal portion adjacent the core member. Each catheter includes a distal end coupled to the core member distal end, a proximal end movable relative to the core member, and a lumen extending between the proximal and distal ends for receiving a source of radiation therealong. The balloon is expandable independently of the catheters such that the balloon may be expanded after expanding the catheters, e.g., to facilitate imaging and/or dose planning. Optionally, a working channel may be provided for receiving an aspiration catheter or other instrument or at least one of the catheters may include an aspiration lumen and one or more ports, e.g., for aspirating material from a region surrounding the distal portion.

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Номер записи: 12

03-05-2012 дата публикации

Antiproton production and delivery for imaging and termination of undesirable cells

Номер: US20120108958A1

Автор: Gerald P. Jackson

Принадлежит: Individual

Systems and methods for using antiprotons for terminating unwanted or undesirable cells which can be used in the treatment of conditions caused by the existence and/or proliferation of such undesirable cells. Such conditions include cardiovascular ailments, Parkinson's disease, wet macular degeneration, endocrine disorders, dermatological ailments, and cancer. Because of the unique nature of antiprotons and their annihilation characteristics, the preferred antiproton delivery device ( 1010, 1015, 1030 ) embodiments further incorporate detector arrays ( 1050 a ), capable of detecting characteristic emissions in the course of treatment.

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Номер записи: 13

10-05-2012 дата публикации

Multi-lumen instrument for providing radiation to a body cavity

Номер: US20120116146A1

Автор: Carribeth B. Ramey, Rance A. Winkler, Timothy J. Patrick

Принадлежит: Cytyc Corp

A brachytherapy system for treating metastases on and around a patient's spinous process is provided. The device generally includes a catheter member having a proximal portion, a distal portion, and at least one lumen extending therethrough. The distal portion of the catheter member includes first and second branch members that are adapted to be positioned on opposed sides of a patient's spinous process. The device further includes first and second elongate anchoring elements disposed on the first and second branch members, and optionally can include at least one centering mechanism disposed within each of the first and second anchoring elements.

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Номер записи: 14

17-05-2012 дата публикации

Systems and methods for optimization of on-line adaptive radiation therapy

Номер: US20120123184A1

Автор: Ante Mestrovic, Karl Otto

Принадлежит: British Columbia Cancer Agency BCCA

Radiation treatment methods comprise: obtaining initial image data of a region of interest; initially optimizing one or more radiation delivery variables of a radiation treatment plan based on the initial image data; and dividing the plan into one or more fractional treatments. Each fractional treatment comprises: delivering an initial portion of a fraction based on the one or more initially optimized radiation delivery variables; obtaining fractional image data pertaining to the region of interest; fractionally optimizing the one or more radiation delivery variables based at least in part on the fractional image data; and delivering a subsequent portion of the fraction based on the one or more fractionally optimized radiation delivery variables. At least part of delivering the initial portion of the fraction overlaps temporally with at least one of: obtaining the fractional image data and fractionally optimizing the one or more radiation delivery variables.

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Номер записи: 15

17-05-2012 дата публикации

Catheter guidance of external energy for renal denervation

Номер: US20120123243A1

Автор: Roger Hastings

Принадлежит: Boston Scientific Scimed Inc

An in vivo apparatus includes a flexible shaft having a proximal end, a distal end, and a length sufficient to access a patient's renal artery relative to a percutaneous access location. An energy guide apparatus is provided at the distal end of the shaft and dimensioned for deployment within the renal artery. An ex vivo apparatus includes an arrangement configured to localize the energy guide apparatus within the renal artery, and an energy source configured to direct ablative energy to target tissue located a predetermined distance from the localized energy guide apparatus. The target tissue includes perivascular renal nerve tissue adjacent the renal artery.

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Номер записи: 16

31-05-2012 дата публикации

Devices and methods related to radiation delivery

Номер: US20120134471A1

Автор: Chawalit Dan Krautim, Matthew Alderson, Robert E. Wallace

Принадлежит: Individual

Devices and methods are disclosed which relate to the calibration and quality assurance of motion tracking enabled radiation therapy machines. A phantom, capable of mimicking human breathing through inflation and deflation of the lungs, houses an independently moving target (tumor) that detects the amount of radiation received from the radiation therapy machine. This amount can be compared with a desired amount to determine if adjustment or repositioning is necessary. The servo-mechanism(s) of the motion tracking enabled radiation therapy machine(s) are adjusted in comparison of detected versus programmed motion of the respiring phantom having incorporated independently moving target that incorporated radiation dose detector(s). In the invention, motion tracking and irradiation mechanisms of the radiation therapy machine are adjusted to calibrate with reference to performance specifications of the radiation therapy machine.

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Номер записи: 17

14-06-2012 дата публикации

Shield type radiation therapy and imaging hybrid device

Номер: US20120150018A1

Автор: Fumihiko Nishikido, Hideo Murayama, Taiga Yamaya, Taku Inaniwa

Принадлежит: NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES

A shielding structure against nuclear fragments (referred to as a shield) is operated according to ON and OFF of beam irradiation so as to reduce incidence of nuclear fragments on detectors during beam irradiation. This enables measurement of annihilation radiations and three-dimensional imaging of the irradiation field immediately after irradiation or even during irradiation.

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Номер записи: 18

21-06-2012 дата публикации

Seven or more degrees of freedom robotic manipulator having at least one redundant joint

Номер: US20120158017A1

Автор: Michael P. Naylor, Sohail Sayeh

Принадлежит: Individual

A robotic treatment delivery system including a linear accelerator (LINAC), and a robotic manipulator coupled to the LINAC. The robotic manipulator is configured to move the LINAC along seven or more degrees of freedom, at least one of the seven degrees of freedom being a redundant degree of freedom.

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Номер записи: 19

28-06-2012 дата публикации

Mobile x-ray unit

Номер: US20120163551A1

Автор: Wim De JAGER

Принадлежит: Nucletron Operations BV

One embodiment of the present disclosure is directed to a mobile X-ray unit. The mobile X-ray unit may include a base and an arm associated with the base. The arm may be configured to support an X-ray applicator having an X-ray tube. The X-ray tube may be configured to generate an X-ray beam. The X-ray applicator may include an exit surface through which the X-ray beam passes in use. The X-ray unit may further include an applicator cap for covering at least the exit surface of the X-ray applicator.

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Номер записи: 20

05-07-2012 дата публикации

Chroman derivatives, medicaments and use in therapy

Номер: US20120172424A1

Автор: Alan Husband, Andrew Heaton

Принадлежит: Marshall Edwards Inc

Novel chroman derivatives and intermediate compounds, compositions containing same, methods for their preparation and uses thereof as therapeutic agents particularly as anti-cancer and chemotherapeutic selective agents are described.

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Номер записи: 21

12-07-2012 дата публикации

Bio-absorbable brachytherapy strands

Номер: US20120178984A1

Автор: Gary A. Lamoureux, James Matons

Принадлежит: BIOCOMPATIBLES UK LTD

Provided herein are bio-absorbable strands for use in brachytherapy. In an embodiment, a plurality of discrete hollow bio-absorbable segments spaced apart from one another and encapsulated using a bio-absorbable material to form an elongated member configured to be implantable in patient tissue using a hollow needle. Each hollow bio-absorbable segment has a length, an outer periphery and an inner channel. Radioactive material is within at least a portion of the inner channel or coating at least a portion of the outer periphery of each hollow bio-absorbable segment. Contrast material is within at least a portion of the inner channel or coating at least a portion of the outer periphery of each hollow bio-absorbable segment.

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Номер записи: 22

02-08-2012 дата публикации

Mobile X-Ray Unit

Номер: US20120195405A1

Автор: Bas Woudstra, Wim De JAGER

Принадлежит: Nucletron Operations BV

One embodiment of the present disclosure is directed to a mobile X-ray unit. The mobile X-ray unit may include a base accommodating a control unit for controlling an X-ray applicator and a power supply for supplying power to the X-ray applicator. The mobile X-ray unit may further include an arm associated with the base. The arm may be configured to support an X-ray applicator having an X-ray tube. The arm may be articuable. The X-ray tube may include a target element configured to generate an X-ray beam and a collimator configured to shape the X-ray beam. The target element may be disposed at a set distance from the collimator.

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Номер записи: 23

02-08-2012 дата публикации

Ubiquitin interacting motif peptides as cancer therapeutics

Номер: US20120197059A1

Автор: HONG Chen, Yunzhou DONG

Принадлежит: Oklahoma Medical Research Foundation

The present invention involves the use peptides comprising ubiquitin interacting motifs (UIMs) alone or in combination with other agents to treat diseases involving neovascularization, such as cancer.

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Номер записи: 24

09-08-2012 дата публикации

Radiotherapy device controller and method of measuring position of specific-part

Номер: US20120199760A1

Автор: Kenji Takayama, Kunio Takahashi, Masahiro Hiraoka, Takanobu Handa, Takashi Mizowaki, Yuichiro Narita

Принадлежит: KYOTO UNIVERSITY, Mitsubishi Heavy Industries Ltd

A radiotherapy device controller includes: a visual line calculator configured to calculate a visual line based on a position on a transmissive image imaged using a radiation penetrating a subject, a specific part of the subject being shown at the position; a position calculator configured to calculate a position of the specific part based on a position of a trajectory of the specific part and a position of the visual line; and an emitter configured to control a radiation emitter that emits a therapeutic radiation, so that the therapeutic radiation penetrates at the position of the specific part.

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Номер записи: 25

23-08-2012 дата публикации

Particle beam therapy system

Номер: US20120211667A1

Автор: Hisashi Harada, Kengo Sugahara, Takaaki Iwata

Принадлежит: Mitsubishi Electric Corp

The objective is to eliminate the effect of the hysteresis of a scanning electromagnet and resume high-accuracy beam irradiation from an irradiation position where it has been interrupted, even in the case where emergency-stop processing is performed during therapy. There are provided an irradiation management apparatus that controls a scanning electromagnet; and an interlock information inputting device that generates an interlock signal for stopping irradiation of the charged particle beam, when a contingency occurs. When irradiation of the charged particle beam is resumed, the irradiation management apparatus performs idle operation in which the scanning electromagnet is controlled, with the charged particle beam unirradiated, from a start step, which is situated prior to a stop step and is different from the initial step in actual irradiation, to the stop step, and then irradiates the charged particle beam from the desired irradiation position coordinates corresponding to the stop step.

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Номер записи: 26

23-08-2012 дата публикации

Adaptive x-ray control

Номер: US20120213333A1

Автор: John W. Allison

Принадлежит: Individual

Controlling the timing of acquiring x-ray images based on target movement.

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Номер записи: 27

23-08-2012 дата публикации

Apparatus and method for effecting radiation treatment on a pre-selected anatomical portion of an animal body

Номер: US20120215052A1

Автор: Arie Luite Visscher, Johan Henning, Johann Kindlein, Wouter Peter Engels

Принадлежит: Nucletron Operations BV

A medical apparatus for effecting radiation treatment on a pre-selected anatomical portion of an animal body is disclosed. The medical apparatus may include a plurality of treatment channels configured to be positioned adjacent a body tissue and a plurality of delivery channels coupled to a corresponding number of treatment channels. The medical apparatus may also include a plurality of source channels configured to receive one or more energy sources, a tracking channel configured to receive a tracking element, and a connecting element configured to connect each delivery channel with either one of the plurality of sources channels or the tracking channel.

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Номер записи: 28

06-09-2012 дата публикации

System and method for automated cyclotron procedures

Номер: US20120223246A1

Автор: Christian Baumgarten, Heinrich ROECKEN, Jan Timmer, Thomas STEPHANI, Uwe Behrens

Принадлежит: Varian Medical Systems Particle Therapy GmbH and Co KG

Systems and methods are provided to perform efficient, automatic cyclotron initialization, calibration, and beam adjustment. A process is provided that allows the automation of the initialization of a cyclotron after overnight or maintenance imposed shutdown. In one embodiment, five independent cyclotron system states are defined and the transition between one state to another may be automated, e.g., by the control system of the cyclotron. According to these embodiments, it is thereby possible to achieve beam operation after shutdown with minimal manual input. By applying an automatic procedure, all active devices of the cyclotron (e.g., RF system, extraction deflectors, ion source) are respectively ramped to predefined parameters.

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Номер записи: 29

06-09-2012 дата публикации

Particle beam irradiation system

Номер: US20120223247A1

Автор: Masahiro Ikeda, Taizo Honda

Принадлежит: Mitsubishi Electric Corp

A particle beam irradiation system comprises deflection electromagnets which scan by deflecting the particle beam in two dimensions in the lateral direction which is perpendicular to an irradiation direction of the particle beam, and an energy width expanding device through which the particle beam passes so as to expand an energy width of the particle beam and form a SOBP in a depth direction of the irradiation target, that is, in an irradiation direction of the particle beam, wherein the energy width expanding device is configured to form the SOBP in the depth direction along whole irradiation area in the depth direction of the irradiation target, and the deflection electromagnets are controlled so as for an irradiation spot which is formed in the irradiation target by the particle beam to move stepwise along whole irradiation area in the lateral direction of the irradiation target.

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Номер записи: 30

13-09-2012 дата публикации

Multi-source radiation system and method for interwoven radiotherapy and imaging

Номер: US20120230464A1

Автор: Athanasios ETMEKTZOGLOU, C. Clifton LING, Edward Shapiro, Margie A. HUNT, Pengpeng ZHANG

Принадлежит: SLOAN KETTERING INSTITUTE FOR CANCER RESEARCH, Varian Medical Systems Inc

An arc radiotherapy and imaging system is provided which includes a first radiation source and a second radiation source. The first radiation source is suitable for treating a region of a patient, and the second radiation source is suitable for imaging the region of the patient. A control is also provided for automatically adjusting system operation, according to a defined schedule, between treating the region of the patient using the first radiation source and imaging the region of the patient using the second radiation source, thereby facilitating both treating and imaging of the region of the patient.

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Номер записи: 31

04-10-2012 дата публикации

Validating a compensator for use in a radiation therapy machine to treat a cancer patient

Номер: US20120250824A1

Автор: John M. Wright, Michael J. Hudson, William Tomer

Принадлежит: Axellis Ventures Ltd

A method of validating a compensator for use in a radiation therapy machine to treat a cancer patient involves determining a radiation treatment plan based on a compensator description file that includes data representative of an actual machined surface of the compensator. The plan includes operating parameters of the radiation therapy machine, and this plan is compared against actual radiation measurements taken during a non-patient test of the radiation therapy machine with the compensator mounted to the machine. If the comparison results in a match, the compensator is validated for use in the radiation therapy machine to treat the cancer patient.

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Номер записи: 32

04-10-2012 дата публикации

Method and Composition to Increase Radiation-Induced Tumor Therapeutic Effects

Номер: US20120252883A1

Автор: Branka Stancevic, Dror Harats, Michel Sadelain, Nira Varda-Bloom, Richard N. Kolesnick, Zvi Fuks

Принадлежит: Memorial Sloan Kettering Cancer Center, Vascular Biogenics Ltd

Disclosed herein are methods and compositions for treating cancer by increasing radiation-induced damage to cancer without increasing radiation-induced side effects by increasing secretory ASMase levels specifically in tumor endothelium, and inducing apoptosis of tumor endothelial cells by treating the tumor with radiation. ASMase levels are increased in tumor endothelium by administration of a recombinant DNA construct comprising a region coding for a functional ASMase linked to particular transcriptional regulatory sequences that confer tissue-specific expression of ASMase.

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Номер записи: 33

04-10-2012 дата публикации

Radiation therapy apparatus and control method

Номер: US20120253096A1

Автор: Manabu Teshigawara

Принадлежит: Toshiba Corp, Toshiba Medical Systems Corp

According to one embodiment, a radiation therapy apparatus includes a radiation irradiation device, a detector included in a PET scanner, a control unit, and a PET image reconstruction unit. The radiation irradiation device emits a therapeutic radiation. The detector counts light derived from gamma rays, and is provided with a gap portion through which the therapeutic radiation passes on a plane of rotation about the body axis of a subject. The control unit controls the radiation irradiation device and the detector so as to rotate in synchronization with each other in a state capable of emitting the therapeutic radiation to the gap portion. The PET image reconstruction unit reconstructs a PET image based on position information at the time of counting of the detector that nearly coincidentally counts pair annihilation gamma rays in a state where the control unit performs rotation control.

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Номер записи: 34

04-10-2012 дата публикации

Prediction of breathing signal and determining non-periodicity of breathing using signal-phase histogram

Номер: US20120253217A1

Автор: Hassan Mostafavi

Принадлежит: Varian Medical Systems Inc

A method of processing breathing signals of a subject includes obtaining breathing signals of a subject, obtaining a signal-phase histogram using the breathing signals, wherein the signal-phase histogram comprises a plurality of data points, each of the data points having at least a phase value and a signal value, determining a reference value using at least some of the plurality of data points from the signal-phase histogram, determining whether a difference between the reference value and a signal value that is associated with a current respiratory cycle exceeds a threshold, and generating an output when the difference exceeds the threshold. A method of predicting breathing signal is also provided.

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Номер записи: 35

04-10-2012 дата публикации

Defining the volumetric dimensions and surface of a compensator

Номер: US20120253495A1

Автор: John M. Wright, Michael J. Hudson, William Tomer

Принадлежит: Axellis Ventures Ltd

A compensator is used with a radiation therapy machine to treat a cancer patient. A three-dimensional surface of the compensator is defined by obtaining a radiation dose requirement created by a treatment planning system associated with the radiation therapy machine and determining a plurality of grid elements based on that radiation dose requirement. At least one of a plurality of points on each of the plurality of grid elements is connected with at least one of the plurality of points on another one of the plurality of grid elements to form a representation of the three-dimensional compensator.

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Номер записи: 36

18-10-2012 дата публикации

Radiolabeled compound directable in vivo to target tissue and use thereof

Номер: US20120263645A1

Автор: Koki Hasegawa, Yasuyoshi Watanabe

Принадлежит: RIKEN Institute of Physical and Chemical Research

The present invention provides a clinically usable radiolabeled compound that is precisely directable in vivo to a target tissue. The compound of the present invention has a first polypeptide or an analogue thereof, and a second polypeptide bonded to an N-terminus of the first polypeptide or the analogue thereof. In the compound, the first polypeptide is a polypeptide that specifically binds with a protein expressed in a target tissue, the second polypeptide has an amino acid region that has a high affinity for a radioactive metal nuclide, and the radioactive metal nuclide that has a high affinity for the amino acid region is held in the amino acid region.

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Номер записи: 37

06-12-2012 дата публикации

Local Adjustment Device For Radiotherapy

Номер: US20120305007A1

Автор: DI Yan

Принадлежит: William Beaumont Hospital

A cradle for positioning an anatomical portion of a patient during treatment includes a plurality of expandable fluid chambers and a pressure regulator configured to supply fluid to and withdraw fluid from each of the fluid chambers. A system for positioning an anatomical portion of a patient during treatment includes the aforementioned cradle and a control unit configured to control the pressure of each of the fluid chambers. A method for positioning an anatomical portion of a patient during treatment comprises the steps of placing the anatomical portion in the aforementioned cradle and adjusting the pressure of each of the fluid chambers to hold the anatomical portion in a desired position.

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Номер записи: 38

20-12-2012 дата публикации

Data processing for real-time tracking of a target in radiation therapy

Номер: US20120323062A1

Автор: J. Nelson Wright, Ryan K. Seghers, Stephen C. Phillips, Steven C. Dimmer

Принадлежит: Individual

A facility for processing data is described. The facility receives a stream of digital location indications, each location indication identifying a location of a patient while undergoing radiation therapy. In response to each location indication of the string, in substantially real-time relative to the receipt of the position indication, the facility performs an action responsive to the location indication.

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Номер записи: 39

20-12-2012 дата публикации

Patient alignment system with external measurement and object coordination for radiation therapy system

Номер: US20120323516A1

Автор: Chieh C. Cheng, Daniel C. Anderson, Daniel W. Miller, David A. Lesyna, Michael A. Baumann, Michael F. Moyers, Nickolas S. Rigney

Принадлежит: LOMA LINDA UNIVERSITY

A patient alignment system for a radiation therapy system. The alignment system includes multiple external measurement devices which obtain position measurements of components of the radiation therapy system which are movable and/or are subject to flex or other positional variations. The alignment system employs the external measurements to provide corrective positioning feedback to more precisely register the patient and align them with a radiation beam. The alignment system can be provided as an integral part of a radiation therapy system or can be added as an upgrade to existing radiation therapy systems.

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Номер записи: 40

03-01-2013 дата публикации

Applicator for applying a radioactive substance to a biological tissue

Номер: US20130006033A1

Автор: Cesidio Cipriani, Maria Desantis, Mark Harfensteller, Max Bichlmaier, Oliver Buck, Siegfried Förg, Tuomo Kaarlo Nikula

Принадлежит: ITM ISOTOPEN TECHNOLOGIEN MUENCHEN AG

An applicator for applying a radioactive substance to a biological tissue, the applicator comprising a container for receiving the radioactive substance; an application device connectable to the container, by which the substance compound can be applied to the tissue; and at least a part of a conveying device by which the radioactive substance can be supplied from the container into the application device when the application device has been connected to the container.

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Номер записи: 41

03-01-2013 дата публикации

Tissue irradiation

Номер: US20130006037A1

Автор: Michael L. Jones, Paul Lubock

Принадлежит: SenoRx Inc

Devices and methods are disclosed for treatment to tissue surrounding a body cavity or other intracorporeal site, such as after removal of tissue, e.g. cancer. Such a device includes a treatment location on a distal portion of the device with one or more radiation shielding components that partially encircle a radiation source at the treatment location to control emitted radiation from the radiation source. The device minimizes radiation damage to healthy tissue surrounding the body cavity or other site while irradiating tissue not shielded by the radiation shielding components. A device embodying features of the invention can include a sealing member at a location on a shaft of the device proximal to a treatment location to seal the passageway leading to the body cavity.

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Номер записи: 42

07-02-2013 дата публикации

Device using x-rays to highlight soft-tissue parts in medical radiotherapy

Номер: US20130034208A1

Автор: Jurgen Heller, Oliver Heid

Принадлежит: SIEMENS AG

A device and method for using X-rays to highlight soft-tissue parts in medical imaging are provided. The device may be implemented in radiotherapy equipment or used in radiotherapy. A control of the radiation dose needed for the therapy may involve phase-contrast imaging using X-rays to highlight soft-tissue parts. The result of the imaging by highlighting soft-tissue parts can be used for real-time and non-real-time planning of therapy and for adapting the treatment plan or the radiation dose. The radiation dose control may include anatomical imaging for locating tumours before, during and after irradiation and/or real-time adaptation of the treatment plan based on imaging that highlights soft-tissue parts. The positioning and arrangement of the combination of X-ray sources and detector in such a radiotherapy apparatus and of an accelerator may be independent of one another. The accelerator makes it possible to cover the entire body of the patient with X-rays.

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Номер записи: 43

14-03-2013 дата публикации

METHOD AND COMPOSITION FOR HYPERTHERMALLY TREATING CELLS

Номер: US20130066190A1

Автор: PEYMAN Gholam A.

Принадлежит:

A method and composition for hyperthermally treating tumor cells in a patient under conditions that affect tumor stem cells and tumor cells. In one embodiment, the method is administered in combination with localized internal ionizing radiation therapy. 1. A method of simultaneously providing localized internal ionizing radiation therapy in combination with thermal therapy to a target site in a patient in need thereof , the method comprisingadministering to the patient a composition of nanoparticles, the nanoparticles containing at least one radioactive isotope and coated with anti-tumor antibodies, the radioactive nanoparticle resulting in radiation therapy at a dose sufficient to damage tumor-associated vessels at the localized target site, andadministering localized thermal therapy at the target site essentially simultaneously during the radiation therapy.3. The method of where the target is a tumor site.4. The method of where the target is neovascularization tissue.5. The method of where the target is endothelial cells in new blood vessels in a patient with exudative age related macular degeneration.6. The method of wherein the radioactive nanoparticle is a magnetic claim 1 , diamagnetic claim 1 , ferromagnetic claim 1 , non-ferromagnetic and/or paramagnetic nanoparticle.7. The method of wherein the antitumor antibody is coated on or conjugated with the radioactive nanoparticle.8. The method of wherein the composition is administered intravenously.9. The method of wherein the radioactive isotope is an α-emitting isotope claim 1 , a β-emitting isotope claim 1 , or a combination thereof.10. The method of wherein the isotope is selected from the group consisting of AtAc claim 9 , Bi claim 9 , Bi claim 9 , Ra claim 9 , Pb claim 9 , Tb claim 9 , I claim 9 , cu claim 9 , I claim 9 , Bi claim 9 , and Bi11. The method of wherein the dose of the isotope ranges from 10 μCi to 20 claim 9 ,000 μCi.12. The method of wherein thermal therapy is applied with a controlled energy ...

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Номер записи: 44

21-03-2013 дата публикации

Multi-Leaf Collimator for Proton Beam Therapy

Номер: US20130072744A1

Автор: Cheng Chee Wai, Moskvin Vadim

Принадлежит:

A proton beam collimator comprising (a) titanium or (b) stainless steel containing no tungsten or (c) containing no tungsten or brass. The collimator comprises a multi-leaf collimator (MLC). The apparatus further comprises an integrated circuit (IC) mounted adjacent the collimator, the IC subject to exposure to atomic particles, illustratively, neutrons. 1. A proton beam collimator made from titanium.2. The device of wherein the collimator comprises a multi-leaf collimator (MLC).3. The device of further comprising an integrated circuit (IC) mounted adjacent the collimator claim 2 , the IC subject to exposure to atomic particles.4. The device of further comprising an integrated circuit (IC) mounted adjacent the collimator claim 3 , the IC subject to exposure to neutrons.5. The device of further comprising an integrated circuit mounted adjacent the collimator claim 1 , the IC subject to exposure to atomic particles.6. The device of further comprising an integrated circuit (IC) mounted adjacent the collimator claim 5 , the IC subject to exposure to neutrons.7. A proton beam collimator made from stainless steel including no tungsten.8. The device of wherein the collimator comprises a multi-leaf collimator (MLC).9. The device of further comprising an integrated circuit (IC) mounted adjacent the collimator claim 8 , the IC subject to exposure to atomic particles.10. The device of further comprising an integrated circuit (IC) mounted adjacent the collimator claim 9 , the IC subject to exposure to neutrons.11. The device of further comprising an integrated circuit mounted adjacent the collimator claim 7 , the IC subject to exposure to atomic particles.12. The device of further comprising an integrated circuit (IC) mounted adjacent the collimator claim 11 , the IC subject to exposure to neutrons.13. A proton beam collimator including no tungsten and no brass.14. The device of wherein the collimator comprises a multi-leaf collimator (MLC).15. The device of further comprising ...

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Номер записи: 45

21-03-2013 дата публикации

TRACKING REPRESENTATIONS OF INDICATOR BODY PARTS

Номер: US20130072745A1

Автор: Berlinger Kajetan, Brumme Stephan

Принадлежит:

The present invention relates to a method for tracking image sections which represent indicator body parts of a body in a process sequence of images, wherein changes in the position of the indicator body parts are used as an indicator for changes in the position of a treatment body part of the body which is to be treated using a treatment beam, said method comprising the following steps: providing advance image data which describe an advance sequence of images representing a result of an advance analysis of the body; providing process image data which describe the process sequence of images, wherein the process sequence of images represents a result of a process analysis of the body which is performed after the advance analysis; determining, on the basis of the advance image data, sub-images which undergo similar changes in position in the advance sequence; extracting, on the basis of the process image data and the determined sub-images, image sections from the images of the process sequence which have an image content which corresponds to the image content of the determined sub-images; and tracking the extracted image sections in the process sequence. 1. A method for tracking image sections which represent indicator body parts of a body in a process sequence of images , wherein changes in the position of the indicator body parts are used as an indicator for changes in the position of a treatment body part of the body which is to be treated using a treatment beam , said method comprising the following steps:providing advance image data which describe an advance sequence of images representing a result of an advance analysis of the body;providing process image data which describe the process sequence of images, wherein the process sequence of images represents a result of a process analysis of the body which is performed after the advance analysis;determining, on the basis of the advance image data, sub-images which undergo similar changes in position in the advance ...

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Номер записи: 46

28-03-2013 дата публикации

Particle beam irradiation apparatus and particle beam therapy system

Номер: US20130075622A1

Автор: Tadashi Katayose

Принадлежит: Mitsubishi Electric Corp

The particle beam irradiation apparatus irradiates a charged particle beam accelerated by a accelerator onto an irradiation subject; the particle beam irradiation apparatus includes a scanning electromagnet that scans the charged particle beam, and a scanning electromagnet moving apparatus that moves the scanning electromagnet in such a way as to change the distance between the scanning electromagnet and the irradiation subject in the beam axis direction of the charged particle beam.

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Номер записи: 47

28-03-2013 дата публикации

Radiation catheter with multilayered balloon

Номер: US20130079580A1

Автор: Richard L. Quick

Принадлежит: SenoRx Inc

A catheter device for irradiating tissue surrounding a body site within a body of a patient, includes an elongated shaft which has a distal portion configured to be deployed within the body site. A treatment location at the distal portion has one or more radiation guides configured to receive a radiation source to irradiate tissue at least in part surrounding the body site. An inflatable multilayered balloon is located to surround the treatment location with a wall thereof having at least two layers including a first layer separate from, inside, and in contact with a second layer around an entire periphery of the first layer, and each of the first layer and the second layer being secured to the distal portion of the elongated shaft.

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Номер записи: 48

04-04-2013 дата публикации

Real-time tracking radiation therapy system

Номер: US20130083895A1

Автор: Toru Umekawa, Yusuke Fujii

Принадлежит: HITACHI LTD

A real-time tracking radiotherapy system includes, therapeutic radiation irradiation device, at least two X-ray imaging devices, a target position recognizing section, a therapeutic radiation irradiation control section, each X-ray imaging device including an X-ray, an X-ray detector, and X-ray variable diaphragms, a transit region calculation section, a radiography range setting section, and a diaphragm control section. The real-time tracking radiotherapy system is capable of appropriately setting a radiography range using a computed transit region of a target or an surrogate marker and achieving a reduction in the amount of X-ray exposure.

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Номер записи: 49

04-04-2013 дата публикации

Proton therapy beam-sharing panel display and controls

Номер: US20130086500A1

Автор: Brian SPATOLA, Julie Clift, Richard Kane

Принадлежит: Varian Medical Systems Inc

Systems and methods are described herein to provide a user-interface to visualize and control a beam request panel for requesting allocation of usage of a shared therapy beam. The user interface allows a user to visualize a beam request queue, to request the shared therapy beam for treatment, to estimate when a beam request will be fulfilled, and to cancel a beam request if needed.

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Номер записи: 50

11-04-2013 дата публикации

SIMULTANEOUS MULTI-MODALITY INVERSE OPTIMIZATION FOR RADIOTHERAPY TREATMENT PLANNING

Номер: US20130090549A1

Автор: Kaus Michael, Meltsner Michael, Xiong Ying

Принадлежит: KONINKLIJKE PHILIPS ELECTRONICS N.V.

When performing multimodal radiotherapy planning, an optimizer () concurrently optimizes a combined treatment plan that employs an intensity modulated radiotherapy (IMRT) device () and an intensity modulated proton therapy (IMPT) that respectively generate a photon beam and an ion beam for treating a volume of interest () in a patient (). A simulator () iteratively generates multiple variations of a simulation model () according to optimization parameters that are varied by the optimizer () until the simulation model () satisfies user-entered treatment objective criteria () (e.g., maximum dose, does placement, etc.) 1. A system that facilitates optimization of a multimodal radiation therapy plan employing both photon beam and ion beam radiation treatments , including: a display on which is presented to the user information related to one or more radiation treatment plan simulation models;', 'an optimizer that concurrently optimizes dose delivery from a photon therapy device and an ion therapy device in one or more simulation models by iteratively adjusting a plurality of optimization parameters for each of the photon therapy device and the ion therapy device during simulation; and, 'an input graphical user interface (GUI) that includesa simulator that generates the one or more simulation models according to the optimization parameters.2. The system according to claim 1 , wherein the optimizer identifies an optimal simulation model that satisfies predefined radiation treatment objective criteria.3. The system according to claim 1 , further including:a diagnostic scanner that acquires image data of a volume of interest in a patient to be treated using a combined photon and ion radiation treatment; anda reconstruction processor that reconstructs the acquired image data into one or more images that are used by the simulator to identify contours of the patient and the volume of interest to be treated.4. The system according to claim 1 , wherein the ion therapy device ...

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Номер записи: 51

02-05-2013 дата публикации

Shaped Conforming Medical Balloons

Номер: US20130109906A1

Автор: Tamsen Valoir

Принадлежит: RadiaDyne LLC

A shaped medical balloon is provided that has a conforming shape, yet is inexpensive to manufacture.

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Номер записи: 52

09-05-2013 дата публикации

Compounds Useful as Inhibitors of ATR Kinase

Номер: US20130115314A1

Автор: Charrier Jean-Damien, KAY David

Принадлежит: VERTEX PHARMACEUTICALS INCORPORATED

The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. 2. The compound of claim 1 , wherein Ring B is phenyl claim 1 , thienyl claim 1 , or morpholinyl.3. The compound of claim 2 , wherein Ring B is phenyl.4. The compound of claim 1 , wherein Jis H claim 1 , CH claim 1 , OH claim 1 , OCH claim 1 , CHOH claim 1 , CHNHCH claim 1 , CHNH-cyclopropyl claim 1 , CH(CHF)NH claim 1 , CH(CH)NH claim 1 , CHNH-(tetrahydrofuranyl) claim 1 , CHNH-(oxetanyl) claim 1 , or piperazinyl.5. The compound of claim 1 , wherein Q is phenyl.6. The compound of claim 5 , wherein p is 0; q is 1; and Jis a Caliphatic group wherein one methylene unit is replaced with S(O).7. The compound claim 6 , wherein Jis —SOCH(CH).9. The compound of claim 8 , wherein Jis H claim 8 , Calkyl; and Jis Calkyl.10. The compound of claim 8 , Jand Jjoin together to form a 3-6 membered fully saturated monocyclic ring having 0-2 heteroatoms selected from the group consisting of oxygen claim 8 , nitrogen claim 8 , and sulfur.11. The compound of claim 8 , wherein Jis hydrogen claim 8 , methyl or ethyl; Jis methyl or ethyl; or Jand Jjoin together to form cyclopropyl claim 8 , cyclobutyl claim 8 , cyclopentyl claim 8 , piperidinyl claim 8 , or tetrahydropyranyl.12. The compound of claim 1 , whereinRing B is phenyl or thienyl;{'sup': 2', '3, 'Jis methyl and Jis methyl;'}{'sup': '4', ...

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Номер записи: 53

23-05-2013 дата публикации

Use of a peptide enhancing the ability of radiation therapy to kill cancer cells

Номер: US20130130991A1

Автор: Christian Widmann, Oscar Matzinger

Принадлежит: UNIVERSITÉ DE LAUSANNE

The present invention relates to a peptide consisting essentially of the N2 sequence of the RasGAP protein, a bio logically active fragment thereof, or a variant thereof, which is useful for the preparation of a medicament for the treatment of cancer. Furthermore, it relates to a method of treatment of cancer comprising administering to a subject in need thereof, a therapeutically effective amount of the peptide of the invention.

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Номер записи: 54

23-05-2013 дата публикации

Heart Treatment Kit, System, and Method for Radiosurgically Alleviating Arrhythmia

Номер: US20130131425A1

Автор: Darrin Uecker, Ed Gardner, Oliver Blanck, Patrick Maguire, Tao Cai, Thilaka Sumanaweera

Принадлежит: CyberHeart Inc

Radiosurgical treatments of tissues of the heart mitigate arrhythmias and treat other tumerous and non-tumerous disease using an implanted fiducial positioned in or near the heart using cardiac catheterization techniques. The fiducials may be implanted after diagnostic and planning images of the target tissues have been acquired. Fiducial implantation may take place the day of a scheduled radiosurgical treatment. Techniques to accommodate post-planning fiducial implantation may include registration of the implanted fiducial location with the treatment plan, and active fiducials may limit collateral imaging radiation exposure while enhancing tracking accuracy.

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Номер записи: 55

23-05-2013 дата публикации

Intra-oral device for protecting oral tissues during radiation treatment

Номер: US20130131427A1

Автор: Amy Winston, Bart Johnson

Принадлежит: Bart Johnson and Amy Winston DDS PLLC

An intra-oral device for positioning oral tissues during medical treatment, for example, radiation treatment. The device includes upper and lower dental arch members configured to engage the maxillary and mandibular teeth or edentulous arch(es) of a patient, respectively. The upper and lower dental arch members are operatively coupled to provide a dental arch assembly. A protective element to displace or depress a patient's tongue is secured at a suitable working position with respect to the dental arch assembly. In an embodiment, provision is made for three-dimensional spatial adjustment of the protective element to a desired location, at least during initial fitting and assembly. The device is then secured to allow consistent repetition of the oral tissue positioning from treatment to treatment. The protective element may be configured to engage the tongue of a patient so that the tongue may be selectively positioned for treatment and/or diagnostic procedures.

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Номер записи: 56

30-05-2013 дата публикации

FLEXIBLE ENERGY FILTER FOR ION BEAM THERAPY

Номер: US20130137915A1

Автор: Schippers Jacobus Maarten

Принадлежит: PAUL SCHERRER INSTITUT

An energy filter allows, particularly at lower beam energies, a determined spread of the beam energies in order to preserve the beam edges and to spread the Bragg peak at each individual beam energy. The energy filter behaves similarly to a ridge filter and spreads out the Bragg peak of a low energy proton beam (70-100 MeV) so that energy modulation of the beam can be done with steps of 5 mm in one go over the full range of 235-70 MeV. Due to its mechanical flexibility, the energy filter can be placed on the skin of the patient which minimizes the effect of scattering in the filter due to the short distance behind a layer of a plurality of metal particles within a flexible soft plastic sheet to the skin of the patient. 17-. (canceled)8. An energy filter for particle beam therapy , the energy filter comprising:a flexible carrier formed of a cushion of plastic or water equivalent material or a stack of two or more soft flexible sheets of plastic or water equivalent material; anda layer of a plurality of metal particles in or on said flexible carrier, said layer being attached to a surface of, or embedded in, the cushion or the soft sheet of plastic or water equivalent material;said layer having a cross sectional area corresponding at least to a cross section of a beam scanning area at an outlet of the particle beam equipment prior to an entry into a patient's tissue.9. The energy filter according to claim 8 , wherein said layer is embedded in a soft sheet or between said two soft sheets of plastic or water equivalent material.10. The energy filter according to claim 8 , wherein said metal particles are metal spheres.11. The energy filter according to claim 8 , wherein the cushion or the soft sheet of plastic or water equivalent material has a thickness in a range from 2 to 15 mm claim 8 , preferable 3 to 8 mm claim 8 , and said metal particles have a maximum size of less than 2 mm.12. The energy filter according to claim 11 , wherein the cushion or the soft sheet of ...

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Номер записи: 57

30-05-2013 дата публикации

Target for generating carbon ions and treatment apparatus using the same

Номер: US20130138184A1

Автор: Hyung Ju Park, Moon Youn Jung, Nam Soo Myung, Seunghwan Kim

Принадлежит: Electronics and Telecommunications Research Institute ETRI

Provided are a carbon ion generation target and a treatment apparatus including the same. The treatment apparatus includes a support member, a carbon ion generation target fixed to the support member, and a laser for irradiating laser beam into the carbon ion generation target to generate carbon ions from the carbon ion generation target, thereby projecting the carbon ions onto a tumor portion of a patient. Here, the carbon ion generation target includes a substrate and carbon thin films disposed on the substrate.

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Номер записи: 58

13-06-2013 дата публикации

METHOD AND DEVICE FOR REGISTRATION AND IMMOBILIZATION

Номер: US20130150645A1

Автор: Moyers Michael F.

Принадлежит: LOMA LINDA UNIVERSITY MEDICAL CENTER

Support devices and pods for the head and neck region of patients undergoing radiation therapy are provided herein. The pod generally includes a support shell shaped to generally conform to the shape of the head and neck region of the patient, a foam insert that conforms to the head and neck region of the patient, and an immobilization facemask attached directly to the shell, thereby facilitating close placement of the radiation beam delivery device to the patient and reducing any attenuation and perturbation of radiation doses directed at the patient. The components of the pod are made from materials having properties that reduce any attenuation and perturbation of prescribed radiation doses. 1. A pod for supporting a head and neck region of a patient during radiation treatment , the pod comprising:a shell generally conforming to the head and neck region of the patient, the shell comprising a shell caudal end, a cephalad end, and two lateral portions that are configured to extend generally upward and around the sides of a recumbent patient's head, the lateral portions having a relatively small thickness and tapering to a smaller thickness as the lateral portions extend upward;a facemask configured to attach to the two lateral portions of the support shell to immobilize the patient, the facemask having a first facemask lateral edge and a second facemask lateral edge and configured to extend laterally between the two lateral portions of the support shell; and a first locating pin on a first one of the two lateral portions,', "a second locating pin formed on a second one of the two lateral portions that is on the other side of the patient's head from the first one of the two lateral portions,", 'a first receiving slot near the first facemask lateral edge to receive the first locating pin, and', 'a second receiving slot near the second facemask lateral edge to receive the second locating pin., 'a facemask-to-shell attachment system comprising'}2. The pod of claim 1 , ...

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Номер записи: 59

13-06-2013 дата публикации

INCLINED BEAMLINE MOTION MECHANISM

Номер: US20130150648A1

Автор: Henderson Toby D.

Принадлежит:

A radiotherapy particle emitter positioning device is provided. The positioning device includes first and second arcuate support frames, a mounting carriage and a drive arrangement. The first and second arcuate support frames each include a drive track arrangement defining an arcuate carriage guide path. The mounting carriage is configured for supporting the radiotherapy particle emitter. The mounting carriage is mounted to and supported by the support frames. The mounting carriage is connectable to the drive track arrangements and moveable along the carriage guide path. The mounting carriage also includes the drive arrangement. The drive arrangement engages the drive track arrangements for driving the mounting carriage along the drive track arrangements and the carriage guide path. 1. A radiotherapy particle emitter positioning device comprising:first and second arcuate support frames, each arcuate support frame including a drive track arrangement defining an arcuate carriage guide path;a mounting carriage supported by the support frames, the mounting carriage connectable to the drive track arrangements and moveable along the carriage guide path;the mounting carriage including a drive arrangement engaging the drive track arrangements for driving the mounting carriage along the drive track arrangements.2. The positioning device of claim 1 , wherein the first drive track arrangement includes a first gear rack arrangement and the second drive track arrangement includes a second gear rack claim 1 , drive arrangement including at least two point drive arrangement including a first pinion gear engaging the first gear rack arrangement and a second pinion gear engaging the second gear rack arrangement.3. The positioning device of claim 2 , wherein:the first drive track arrangement includes a first cam track including an upper and a lower cam surface in opposed facing relation and the second drive track arrangement includes a second cam track including an upper and a lower ...

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Номер записи: 60

18-07-2013 дата публикации

Charged particle beam irradiation device

Номер: US20130184512A1

Автор: Satoru YAJIMA

Принадлежит: Sumitomo Heavy Industries Ltd

A charged particle beam irradiation device includes a particle accelerator that accelerates charged particles and ejects a charged particle beam, a cylindrical outer shell part that is capable of rotating around a rotating axis, an irradiation unit that is capable of irradiating an irradiation target with the charged particle beam, the irradiation direction of which changes in accordance with the rotation of the outer shell part, and a beam transport line that transports the charged particle beam ejected from the particle accelerator to the irradiation unit. The particle accelerator and the beam transport line may be at least partially housed within the outer shell part.

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Номер записи: 61

18-07-2013 дата публикации

SKIN CARE METHOD AND SKIN CARE DEVICE

Номер: US20130184513A1

Автор: Nakamura Misaki, Saito Emi

Принадлежит: SHARP KABUSHIKI KAISHA

A skin care method using a closed-bottomed casing having an open surface and an ion generating unit in which discharge is generated in the air by applying a high voltage to generate positive ions and negative ions in the casing includes driving the ion generating unit while the open surface is closed by a skin surface to seal the inside of the casing and bringing ions generated in the ion generating unit into contact with the skin surface. 1. A skin care method using a closed-bottomed casing having an open surface and an ion generating unit in which discharge is generated by applying a high voltage to generate positive ions and negative ions in the casing , the method comprising driving the ion generating unit while the open surface is closed by a skin surface to seal the inside of the casing; and bringing ions generated in the ion generating unit into contact with the skin surface.2. The skin care method according to claim 1 , wherein the positive ions are represented by H(HO)(where m is any natural number) and the negative ions are represented by O(HO)(where n is any natural number).3. The skin care method according to claim 1 , wherein the ions are allowed to naturally diffuse in the casing.4. The skin care method according to claim 1 , wherein the ions are generated while the skin surface is warmed.5. A skin care device comprising a closed-bottomed casing having an open surface; and an ion generating unit in which discharge is generated by applying a high voltage to generate positive ions and negative ions in the casing claim 1 , wherein ions are generated from the ion generating unit which is driven while the inside of the casing is sealed by closing the open surface with a skin surface to bring the ions into contact with the skin surface.6. The skin care device according to claim 5 , wherein the positive ions are represented by H(HO)(where m is any natural number) and the negative ions are represented by O(HO)(where n is any natural number).7. The skin care ...

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Номер записи: 62

25-07-2013 дата публикации

Monochromatic x-ray methods and apparatus

Номер: US20130188773A1

Автор: Eric H. Silver

Принадлежит: Individual

According to some aspects, an x-ray apparatus for imaging and/or radiation therapy is provided, the x-ray apparatus comprises an electron source capable of generating electrons, at least one first target arranged to receive electrons from the electron source, the at least one first target comprising material that, in response to being irradiated by the electrons, emits broad spectrum x-ray radiation, at least one second target arranged to receive at least some of the broad spectrum x-ray radiation, the at least one second target comprising material that, in response to irradiation by broad spectrum x-ray radiation from the first target, emits monochromatic x-ray radiation, and at least one detector positioned to detect at least some of to the monochromatic x-ray radiation emitted from the at least one second target. According to some aspects, a relatively low cost, relatively small footprint x-ray apparatus for generating monochromatic x-ray radiation suitable for medical/clinical purposes and appropriate for use in existing medical facilities such as hospitals and/or small clinical settings is provided.

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Номер записи: 63

15-08-2013 дата публикации

Radiation Therapy Techniques Using Targeted Wave Superposition, Magnetic Field Direction and Real-Time Sensory Feedback

Номер: US20130208867A1

Автор: Christopher V. Beckman

Принадлежит: Individual

New techniques for radiotherapy and radiosurgery are provided. In one aspect of the invention, multiple sources of radiation are provided in a planned frequency and in the same superposable period and polarization, from the same side of a treatment target, focused on a leading structure in the target. In another aspect, refractive models, updated by live feedback, are used to improve dosage distribution by, among other things, optimizing the number, angle and nature of radiation beams. Interstitial beacons and radiation path diversion structures are inserted to improve dosage distribution to a target and avoid critical neighboring structures. In particle therapy, regionally actuable external magnetic fields are used as well, to improve dosage accuracy and avoid collateral damage.

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Номер записи: 64

15-08-2013 дата публикации

Compositions and Methods for Treating Glioblastoma GBM

Номер: US20130209450A1

Автор: Andrew J. Brenner, Eyal Breitbart, Livnat Bangio, Yael Cohen

Принадлежит: Vascular Biogenics Ltd

Methods of treating a malignant glioma in a subject are disclosed. The methods comprise administering to the subject a therapeutically effective amount of a viral vector comprising: (i) a first polynucleotide sequence encoding a Fas-chimera (Fas-c), said first polynucleotide sequence comprising SEQ ID NOs: 2 and 3; and (ii) a second polynucleotide sequence encoding an endothelial cell-specific promoter or a periendothelial cell-specific promoter.

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Номер записи: 65

22-08-2013 дата публикации

CHARGED PARTICLE THERAPY PATIENT CONSTRAINT APPARATUS AND METHOD OF USE THEREOF

Номер: US20130218009A1

Автор: Balakin Vladimir

Принадлежит:

The invention comprises a rapid patient positioning system including a computer and motor controlled patient constraint system, such as a patient head and/or back support system having multiple adjustable degrees of freedom that facilitates accurate, precise, and rapid alignment of a patient relative to a support or table. The patient support system is preferably integrated with a rapid patient positioning system including steps of: positioning a patient relative to the table in a substantially vertical orientation, transitioning the table through a semi-vertical orientation, such as with a robot arm, and orientating the patient and the table in a substantially horizontal orientation, such as in a position for charged particle tumor therapy. Preferably, the robot arm is in common with an arm used to move the patient in traditional proton therapy. 1. An apparatus for treatment of a tumor of a patient using positively charged particles , comprising:a body support surface, comprising a longitudinal axis; 'an adjustable shoulder distance between said left pad and said right pad; and', 'a torso support comprising a left pad slideably attached to said body support surface and a right pad slideably attached to said body support surface, said torso support configured to constrain movement of a left shoulder of the patient with said left pad and a right shoulder of the patient with said right pad relative to said body support surface, said torso support comprisingan accelerator configured to deliver the positively charged particles to the tumor when said body support surface supports the patient.2. The apparatus of claim 1 , further comprising:at least one motor configured to axially translate at least one of said right pad and said left pad relative to the longitudinal axis of said body support surface.3. The apparatus of claim 2 , further comprising:a computer system configured to recall a stored shoulder width ergonomic parameter of the patient, said computer system used ...

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Номер записи: 66

05-09-2013 дата публикации

Pluridirectional Very High Electron Energy Radiation Therapy Systems and Processes

Номер: US20130231516A1

Автор: Dolgashev Valery A., Loo Billy Wiseman, Maxim Peter G.

Принадлежит: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

A compact high-gradient, very high energy electron (VHEE) accelerator and delivery system (and related processes) capable of treating patients from multiple beam directions with great speed, using all-electromagnetic or radiofrequency deflection steering is provided, that can deliver an entire dose or fraction of high-dose radiation therapy sufficiently fast to freeze physiologic motion, yet with a better degree of dose conformity or sculpting than conventional photon therapy. In addition to the unique physical advantages of extremely rapid radiation delivery, there may also be radiobiological advantages in terms of greater tumor or other target control efficacy for the same physical radiation dose. 1. A system for delivering very high electron energy beam to a target in a patient , comprising:An accelerator capable of generating a very high electron energy beam;A beam steering device capable of receiving the beam from the accelerator and steering the beam to the target from multiple directions; andA controller capable of controlling length of time that the beam irradiates the target, the length of time sufficiently fast to freeze physiologic motion, and to control the directions in which the beam steering device steers the beam to the target.2. A system according to wherein the controller is configured to receive information from an imaging device and use the information from the imaging device to control the directions in which the beam steering device steers the beam to the target.3. A system according to wherein the accelerator is a linear accelerator capable of generating a beam of between 75 and 100 MeV.4. A system according to wherein the length of time is less than one second.5. A system according to wherein the beam steering device is selected from the group consisting of electro-magnetic devices and radiofrequency deflector devices.6. A system according to wherein the beam steering device includes a gantry claim 1 , the gantry including multiple beam ports ...

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Номер записи: 67

12-09-2013 дата публикации

Combined radiotherapy ultrasound device

Номер: US20130237822A1

Автор: Bjorn Heismann, Patrick Gross

Принадлежит: SIEMENS AG

In order to minimize radiation directed to a region outside of a target volume of a patient during a radiation therapy and minimize the cost of an image-guided particle therapy system, the particle therapy system includes an ultrasound device having at least one ultrasound transducer positioned abutting or adjacent to an external surface of the patient. The ultrasound device and thus the ultrasound transducer are positioned outside of a beam path of a particle beam between a radiotherapy device generating the particle beam, and the target volume. The ultrasound device is operable to generate data representing the target volume and/or a region outside of the target region while the radiotherapy device directs the particle beam to the target volume. The particle therapy system includes a processor operable to control the radiotherapy device based on a comparison between the generated data representing the target volume and a predetermined treatment plan.

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Номер записи: 68

24-10-2013 дата публикации

Composite type target, neutron generating method in use thereof and neutron generating apparatus in use thereof

Номер: US20130279638A1

Автор: Hiroshi Matsumoto, Hitoshi Kobayashi, Masakazu Yoshioka

Принадлежит: Inter University Research Institute Corp High Energy Accelerator Research Organization

A target is provided herein such that the radioactivation of a member thereof due to protons may be reduced. In order to reduce the radioactivation of the member due to protons, a novel target composed by compositing a beryllium material (or lithium material) and a nonmetal material is used.

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Номер записи: 69

21-11-2013 дата публикации

Emission computed tomography for guidance of sampling and therapeutic delivery

Номер: US20130308845A1

Автор: Mark W. Lenox

Принадлежит: TEXAS A&M UNIVERSITY SYSTEM

Treatment for a variety of diseases often requires guidance for the delivery of either a drug or radiation to the disease site. Positron Emission Tomography (PET) can provide three dimensional positioning of the location of positron emitting radioisotopes that can mark a disease site. However, the inversion of the raw emission projection data into a 3D volume is computationally intensive, and this results in a low update or frame rate. In order to be useful in either guiding a surgeon, or some other automated feedback approach, the update/frame rate must be of sufficient speed that the user can effectively control the process. This approach provides a substantial improvement to the frame rate by taking advantage of iterative reconstruction methodologies to shortcut the reconstruction process.

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Номер записи: 70

28-11-2013 дата публикации

Joint assembly for connecting a long extension panel to a patient support panel of a radiation therapy table and a two-piece patient support table formed thereby

Номер: US20130312184A1

Автор: Bruce Ribble, Charles Klasson, Roger F. Wilson

Принадлежит: Civco Medical Instruments Co Inc

A joint assembly for forming a two part radiation therapy treatment table is disclosed. The treatment table includes a patient support panel to which one portion of the joint assembly is secured, and a table extension panel to which another portion of the joint assembly is secured. The joint assembly self-aligns, self levels, is immediately stable, and locks automatically by its weight and downward pressure. The joint assembly also includes an automatic failsafe secondary lock that resists joint release if upward forces are applied. Disengaging the secondary lock requires and results in no displacement of the two panels. Upon separation of the two panels the lock resets automatically.

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Номер записи: 71

28-11-2013 дата публикации

Ct imaging apparatus and methods

Номер: US20130315367A1

Автор: Christopher Knox, Colin WINFIELD, Kevin Brown

Принадлежит: ELEKTA AB

An apparatus has a patient support, a rotatable gantry supporting a source of imaging radiation, and a radiation detector that operates in a cyclical pattern of an exposure phase followed by a readout phase. For a first detector cycle in which the gantry has a first angle of rotation, the source of radiation is controlled to emit a first radiation beam pulse during the exposure phase, and respective first imaging data is read out during the readout phase. For a second, subsequent detector cycle, it is determined if the gantry has rotated through at least a threshold angular displacement relative to said first angle of rotation, and if so, the source of radiation is controlled to emit a second radiation beam pulse during the exposure phase, and respective second imaging data is read out during the readout phase.

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Номер записи: 72

05-12-2013 дата публикации

Radiation Therapy for Treating Alzheimer's Disease

Номер: US20130323166A1

Автор: Fontanesi James, Marples Brian, Martinez Alvaro A., Wilson George D.

Принадлежит:

A method treating dementia of the Alzheimer's type in a patient by administering ionizing radiation to the brain of the patient. 1. A method for treating dementia of the Alzheimer's type in a patient , the method comprising:administering a therapeutically effective amount of ionizing radiation to the brain of the patient.2. The method of claim 1 , the radiation source is a helium claim 1 , carbon claim 1 , hydrogen claim 1 , proton claim 1 , neutron claim 1 , electron claim 1 , or photon source.3. The method of claim 1 , wherein the radiation is administered externally to the patient.4. The method of claim 1 , wherein the radiation is administered internally to the patient.5. The method of claim 1 , wherein the radiation is administered as an antibody labeled with a radionuclide.6. The method of claim 1 , wherein the radiation is administered in a total dose of 300-1800 cGy at 50% IDL (isodose line) by a focused based radiation source.7. The method of claim 2 , wherein the radiation is administered in a dose of 50 to 300 cGy per day by a linear accelerator.8. The method of claim 2 , wherein the radiation is administered in a dose of 50 to 600 cGy per day by a targeted radiation source.9. The method of claim 2 , wherein the radiation source is a gamma knife or cyber knife.10. The method of claim 1 , wherein the radiation is x-ray radiation.11. The method of claim 1 , wherein the radiation is gamma ray radiation.12. The method of claim 2 , wherein the radiation is targeted to the hippocampal region of the brain.13. The method of claim 2 , wherein the radiation is targeted to the frontal lobe of the brain.14. A method for reducing the number or size of amyloid plaques or the extent of tau tangles in the brain of a patient claim 2 , the method comprising: administering a therapeutically effective amount of ionizing radiation to the brain of the patient.15. A method for inhibiting claim 2 , arresting the development of claim 2 , or preventing the progression of one or ...

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Номер записи: 73

19-12-2013 дата публикации

Real-Time Three-Dimensional Radiation Therapy Apparatus and Method

Номер: US20130336449A1

Автор: Eiji Tanabe

Принадлежит: Accuthera Inc

A radiation therapy apparatus including a robot supporting a robot head; a therapeutic radiation source attached to the robot head; a collimator for adjusting a radiation field shape of therapeutic radiation radiated from the therapeutic radiation source; a first therapeutic radiation detector attached to the robot head; a couch configured to support a patient lying supine thereon; a second therapeutic radiation detector for detecting the therapeutic radiation, disposed opposite the first therapeutic radiation detector with the couch disposed therebetween; at least two X-ray sources and detectors for position detection of a marker and/or a treatment target; an image processor for reconstructing an image of the treatment target; and a CPU that computes the intensity, irradiation direction, dose, and dose distribution of the therapeutic radiation, and dose absorbed by the treatment target, radiation field shape, and position of the treatment target in real time for feedback to a next irradiation.

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Номер записи: 74

26-12-2013 дата публикации

CONFIGURATION MANAGEMENT AND RETRIEVAL SYSTEM FOR PROTON BEAM THERAPY SYSTEM

Номер: US20130345489A1

Автор: Baumann Michael A., Beloussov Alexandre V., Olsen Howard B., Salem Dana

Принадлежит: LOMA LINDA UNIVERSITY MEDICAL CENTER

In a complex, multi-processor software controlled system, such as proton beam therapy system (PBTS), it may be important to provide treatment configurable parameters that are easily modified by an authorized user to prepare the software controlled systems for various modes of operation. This particular invention relates to a configuration management system for the PBTS that utilizes a database to maintain data and configuration parameters and also to generate and distribute system control files that can be used by the PBTS for treatment delivery. The use of system control files reduces the adverse effects of single point failures in the database by allowing the PBTS to function independently from the database. The PBTS accesses the data, parameters, and control settings from the database through the system control files, which insures that the data and configuration parameters are accessible when and if single point failures occur with respect to the database. 1. A radiation beam therapy system comprising: a charged-particle accelerator that provides a beam of energetic charged particles;', 'a treatment station that allows positioning of a patient to receive at least a portion of the beam of charged particles; and', 'a beam delivery system that delivers the beam of charged particles to the patient positioned at the treatment location;, 'a plurality of treatment devices, includinga database component that stores parameters associated with respective treatment devices, wherein the parameters comprise instructional information that can be used to configure the respective treatment devices for operation;an interface component that allows an authorized user to modify at least one of the parameters associated with a respective treatment device; and retrieves a subset of parameters from the database, the subset of parameters including at least one of the stored parameters and modified parameters,', 'generates a data storage element comprising the subset of parameters in a ...

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Номер записи: 75

02-01-2014 дата публикации

Studying dosimetric impact of motion to generate adaptive patient-specific margins in ebrt planning

Номер: US20140005464A1

Автор: Camille Elizabeth Noel, Karl Antonin Bzdusek, Parag Jitendra Parikh, Shyam Bharat

Принадлежит: Koninklijke Philips NV

A treatment planning system ( 106 ) for generating patient-specific treatment margins. The system ( 106 ) includes one or more processors ( 142 ). The processors ( 142 ) are programmed to receive a radiation treatment plan (RTP) for irradiating a target ( 122 ) over the course of one or more treatment fractions. The RTP including one or more treatment margins around the target ( 122 ) and a planned dose distribution for the target ( 122 ). The processors ( 142 ) are further programmed to receive motion data for at least one of the treatment fractions of the RTP from one or more target surrogates ( 124 ), calculate a motion-compensated dose distribution for the target ( 122 ) using the motion data and the planned dose distribution, compare the motion-compensated dose distribution to the planned dose distribution, and adjust the treatment margins based on dosimetric differences between the motion-compensated dose distribution and the planned dose distribution.

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Номер записи: 76

16-01-2014 дата публикации

Charged particle beam treatment planning device and charged particle beam treatment planning method

Номер: US20140018603A1

Автор: Toru Asaba

Принадлежит: Sumitomo Heavy Industries Ltd

There is provided a charged particle beam treatment planning device that creates a treatment plan and is connected to a charged particle beam irradiation apparatus that includes a scanning electromagnet, which scans a charged particle beam, and a degrader, which adjusts a range of the charged particle beam by reducing the energy of the charged particle beam, and irradiates an irradiation object with the charged particle beam. The charged particle beam treatment planning device includes a control unit that adjusts the dose of the charged particle beam, which is irradiated to a predetermined position of the irradiation object, on the basis of a passing distance of the charged particle beam within the degrader calculated using a deflection angle of the charged particle beam.

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Номер записи: 77

23-01-2014 дата публикации

Particle beam irradiation system and operating method

Номер: US20140021375A1

Автор: Hideaki Nishiuchi, Koji TOBINAGA, Masumi Umezawa, Moemi TAKEDA, Satoshi Totake, Seiji YOSHIURA, Takuya Nomura, Tomohisa IMAGAWA

Принадлежит: HITACHI LTD

A particle beam irradiation system having a multi-energy extraction control operation that controls the extraction beam energy in a synchrotron within a short time, such that when the ion beam irradiation is halted, an operating cycle is updated within a short time and a dose rate is improved. To this end, operating control data for each of the devices constituting the synchrotron is constructed by multi-energy extraction control pattern data for controlling extraction of beams of a plurality of energy levels at one operating cycle, and a plurality of sets of deceleration control data that correspond to the extraction control of the beam of the plurality of energy levels. The devices are controlled by using the operating control data.

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Номер записи: 78

23-01-2014 дата публикации

Radiation shielding catheter hub and related methods of use

Номер: US20140025020A1

Автор: Nathan Zamarripa

Принадлежит: Boston Scientific Scimed Inc

Catheter hubs adapted for use with medical devices as well as methods for making and using such catheter hub are disclosed. An example catheter hub may include a hub body having a proximal end, a distal end, and a lumen extending between the proximal end and the distal end. The proximal end of the hub body may include one or more ports and the distal end may be capable of attaching to a catheter shaft. The hub body may include a radiation shielding material.

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Номер записи: 79

30-01-2014 дата публикации

Treatment planning system

Номер: US20140031602A1

Автор: Rintaro Fujimoto, Yoshihiko Nagamine, Yusuke Fujii

Принадлежит: HITACHI LTD

A treatment planning system is provided which, with irradiation parameters varied over time, performs highly accurate dose distribution calculations based on information about tumor movements included in 4D CT images. The system is characterized by the ability to read CT images furnished with timing information and associate the status of the irradiation target corresponding to an elapsed time from the beginning of irradiation with positions being irradiated at corresponding elapsed time points so as to calculate the dose distribution.

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Номер записи: 80

06-02-2014 дата публикации

Image guided radiation therapy

Номер: US20140037062A1

Автор: Clemens Bos, Daniel Robert ELGORT, Lucian Remus Albu

Принадлежит: KONINKLIJKE PHILIPS ELECTRONICS NV

An image guided radiation therapy system comprises a radiation source to generate radiation. Radiation optics forms a therapeutic radiation beam from the therapeutic radiation from the radiation source. An imaging system forms an image of a target zone to control the radiation optics to direct the therapeutic radiation beam onto the target zone. The radiation optics is provided with an optics module configured to generate an imaging photonic beam endowed with optical angular momentum. The imaging system comprises a magnetic resonance assembly to receive magnetic resonance signals the from the target zone generated by imaging photonic beam endowed with optical angular momentum.

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Номер записи: 81

20-02-2014 дата публикации

Energy application apparatus

Номер: US20140051904A1

Автор: Carolina Ribbing, Petrus Wilhelmus Helena VAN LOON, Torsten Solf

Принадлежит: Koninklijke Philips NV

The invention relates to an energy application apparatus for applying energy to an object, wherein the object ( 2 ) comprises a location ( 3 ) with radioactive material and wherein the energy application apparatus ( 1 ) comprises a location detection unit being usable for detecting the location with the radioactive material, and an x-ray unit for applying x-rays to the detected location of the object. Since the location, to which energy should be applied, comprises radioactive material, this location can be accurately detected by using the location detection unit. Moreover, since the application of the x-rays can be well controlled by controlling, for example, the intensity and the energy spectrum of the x-rays, energy can be accurately applied to the accurately detected location. The overall process of applying energy to the object can therefore be performed with increased accuracy.

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Номер записи: 82

20-02-2014 дата публикации

Rectal balloon with sensor cable

Номер: US20140051968A1

Автор: John ISHAM, Tamsen Valoir

Принадлежит: RadiaDyne LLC

An endorectal balloon having a pocket thereon for holding a sensor cable that can be used for radiation dosimetry or to detect motion of the prostate or balloon.

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Номер записи: 83

27-02-2014 дата публикации

Radiation beam analyzer and method

Номер: US20140054453A1

Автор: Daniel Navarro

Принадлежит: Individual

A radiation beam analyzer for measuring the distribution and intensity of radiation produced by a Cyberknife®. The analyzer employs a relative small tank of water into which a sensor is placed to maintain a constant SAD (source to axis distance). A first method maintains a fixed position of detector, and raises or lowers the small tank of water. A second method moves the detector up, down or rotationally synchronously in opposite directions with respect to the small tank of water to keep the SAD constant. These methods position the detector relative to the radiation source to simulate the location of a malady within a patient's body. An embodiment of the present invention enables measurements of substantially larger fields. This is accomplished by rotating a tank of water 90 degrees from a first position to a second position.

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Номер записи: 84

27-02-2014 дата публикации

CHARGED-PARTICLE BEAM IRRADIATION DEVICE

Номер: US20140058186A1

Автор: Sasai Kenzo

Принадлежит: SUMITOMO HEAVY INDUSTRIES, LTD.

A charged-particle beam irradiation device, which irradiates an irradiation target with a charged-particle beam, includes a transport line that transports the charged-particle beam and a rotating gantry that is rotatable about a rotation axis. The transport line includes an inclination portion making the charged-particle beam travel so that the charged-particle beam is inclined to be separated from the rotation axis, and is formed to turn the charged-particle beam in a rotation direction of the rotation axis and to bend the charged-particle beam, which has turned in the rotation direction, toward the rotation axis. The rotating gantry is formed of a cylindrical portion that receives the irradiation target and supports the transport line. The inclination portion is disposed in the cylindrical portion of the rotating gantry. The charged-particle beam irradiation device further includes blocking members that block radiation emitted from the transport line disposed in the cylindrical portion. 1. A charged-particle beam irradiation device that irradiates an irradiation target with a charged-particle beam , the charged-particle beam irradiation device comprising:a transport line that transports the charged-particle beam; anda rotating gantry that is rotatable about a rotation axis,wherein the transport line includes an inclination portion making the charged-particle beam, which travels in a direction of the rotation axis, travel so that the charged-particle beam is inclined to be separated from the rotation axis, and is formed to turn the charged-particle beam, which has traveled through the inclination portion, in a rotation direction of the rotation axis and to bend the charged-particle beam, which has turned in the rotation direction, toward the rotation axis,the rotating gantry is formed of a cylindrical portion that receives the irradiation target and supports the transport line, andthe inclination portion of the transport line is disposed in the cylindrical portion ...

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Номер записи: 85

27-02-2014 дата публикации

Mr imaging guided therapy system

Номер: US20140058248A1

Автор: Christoph Leussler

Принадлежит: Koninklijke Philips NV

The invention relates to a thermal treatment applicator ( 19 ) for the deposition of thermal energy within tissue of a body ( 10 ) of a patient. The applicator ( 19 ), comprises: a plurality of RF antennae ( 20 ) for radiating a RF electromagnetic field toward the body ( 10 );—a plurality of RF power amplifiers ( 21 ) supplying RF signals to the RF antennae ( 20 ), wherein each RF power amplifier ( 21 ) comprises a transistor and an output matching network ( 22 ) transforming the output impedance of the transistor into a low impedance value. Moreover, the invention relates to a MR imaging guided therapy system ( 1 ).

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Номер записи: 86

20-03-2014 дата публикации

Charged particle beam irradiation apparatus

Номер: US20140077098A1

Автор: Toshiki Tachikawa, Tsuyoshi Ogasawara

Принадлежит: Sumitomo Heavy Industries Ltd

A charged particle beam irradiation apparatus includes: an irradiation section configured to irradiate an irradiated body with a charged particle beam; a multi-leaf collimator configured to set an irradiation range of the charged particle beam which is irradiated from the irradiation section; an imaging section that is provided so as to be able to advance and retreat with respect to an irradiation axis of the charged particle beam which is irradiated from the irradiation section, between the irradiation section and the multi-leaf collimator, and directly images an opening portion of the multi-leaf collimator; and a drive section configured to move the imaging section between an imaging position corresponding to an irradiation area which includes the irradiation axis of the charged particle beam and a retreated position away from the irradiation area.

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Номер записи: 87

03-04-2014 дата публикации

Energy degrader and charged particle beam irradiation system equipped therewith

Номер: US20140091238A1

Автор: Takamasa Ueda, Takuya Miyashita

Принадлежит: Sumitomo Heavy Industries Ltd

An energy degrader includes a plurality of attenuating members configured to attenuate the energy of an incident charged particle beam, the plurality of attenuating members having different amounts of energy to be attenuated. A low-energy-side attenuating member that is the attenuating member with a larger amount of energy to be attenuated is made of a material having a higher transmittance of the charged particle beam than that of a high-energy-side attenuating member that is the attenuating member with a smaller amount of energy to be attenuated.

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Номер записи: 88

03-04-2014 дата публикации

Skin dose evaluation support apparatus and treatment planning apparatus

Номер: US20140094642A1

Автор: Hideki Fuji, Yasuyuki Takatani

Принадлежит: Mitsubishi Electric Corp

A skin dose evaluation support apparatus is provided with a skin region contour creation unit that creates skin region information including the boundary coordinates of a skin region, based on image data to be inputted when a treatment plan for a radiation therapy for a patient is created; and a display calculation unit that extracts a skin dose in a skin region, based on dose distribution data calculated by a dose distribution calculation unit of a treatment planning apparatus and the skin region information, and creates display data for displaying the extracted skin dose in a predetermined display format.

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Номер записи: 89

10-04-2014 дата публикации

Targeted Nuclear Fusion Tumor Therapy

Номер: US20140100409A1

Автор: Kime Milford Burton

Принадлежит:

A method and apparatus for treating a tumor in a patient. In one embodiment, the method comprises the steps of: dosing the patient with a substituted tumor-specific agent and irradiating the tumor with energetic ions, the ions having sufficient energy to penetrate into the tumor and cause nuclear fusion reactions, but not to pass through the tumor. In one embodiment, the substituted tumor-specific agent incorporates deuterium. In this embodiment, the energetic ions are tritium nuclei. In this embodiment, the apparatus comprises a tritium ion source, an accelerator producing an ion beam, a scanning mechanism, and a plurality of neutron detectors positioned adjacent to the patient. The tritium ion beam is programmed to traverse the site of the tumor with tritium ions having energy sufficient to penetrate into the tumor and cause nuclear fusion reactions, but not pass through the tumor. 1. A method for treating a tumor in a patient comprising the steps of:dosing the patient with a substituted tumor specific agent; andirradiating the tumor with energetic ions the ions having sufficient energy to penetrate into the tumor and cause a nuclear fusion reaction, but not to pass through the tumor.2. The method of wherein the substituted tumor specific agent incorporates deuterium.3. The method of wherein the energetic ions are tritium nuclei.4. The method of wherein the substituted tumor specific agent incorporates tritium.5. The method of wherein the energetic ions are deuterium nuclei.6. The method of further comprising the step of determining if the dosing of the patient meets predetermined treatment requirements by measuring the concentration of deuterium or tritium in the tumor mass using MRI spectral analysis.7. An apparatus for treating a tumor in a patient dosed with a deuterium substituted tumor specific agent claim 1 , the apparatus comprising:a tritium ion source;a tritium ion beam generating accelerator;a scanning mechanism for scanning the tritium ion beam; anda ...

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Номер записи: 90

07-01-2016 дата публикации

INSTRUMENT LOCALIZATION IN GUIDED HIGH DOSE RATE BRACHYTHERAPY

Номер: US20160000519A1

Автор: DEHGHAN MARVAST EHSAN

Принадлежит:

A system for localizing one or more medical instruments includes a guidance grid () disposed in an operative relationship with a Workstation subject for receiving the one or more medical instruments () when deployed. An ultrasound imaging system () is configured to image a volume where the one or more medical instruments are deployed. A program module () is configured to register positions of the one or more medical instruments, using tracked position information and grid information, to the volume such that the positions of the one or more medical instruments can be visually monitored during a procedure. 1. A system for localizing one or more medical instruments. comprising:a guidance grid disposed in an operative relationship with a subject for receiving the one or more medical instruments when deployed;an ultrasound imaging system configured to image a volume where the one or more medical instruments are deployed; anda program module configured to register positions of the one or more medical instruments, using tracked position information and grid information to the volume, using image data, such that the positions of the one or more medical instruments are visually monitored during a procedure.2. The system as recited in claim 1 , wherein the one or more medical instruments are tracked using one of an electromagnetic tracking system and an optical shape sensing system.3. The system as recited in claim 1 , wherein the guidance grid is calibrated claim 1 , a priori claim 1 , to the imaging system.4. The system as recited in claim 1 , wherein the ultrasound imaging system includes a probe that is not tracked.5. The system as recited in claim 4 , wherein the probe includes a transrectal probe ultrasonic (TRUS) probe.6. The system as recited in claim 1 , wherein the one or more medical instruments include catheters claim 1 , which appear in the volume as bright regions such that the bright regions are employed to register the positions determined by a tracking ...

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Номер записи: 91

06-01-2022 дата публикации

GRAPHICAL REPRESENTATION OF RADIATION THERAPY

Номер: US20220001209A1

Автор: BASSALOW Rostem, OLCOTT Peter Demetri, OWENS Michael Kirk

Принадлежит:

Described herein are methods for monitoring the radiation delivery during a radiotherapy delivery session and providing a graphical representation of radiation delivery to an operator (e.g., a clinician, a medical physicist, a radiation therapy technologist). The graphics are updated in real-time, as radiation data is collected by the radiotherapy system, and in some variations, can be updated every 15 minutes or less. A variety of graphical representations (“graphics”) can be used to indicate the status of radiation delivery relative to the planned radiation delivery. Methods optionally include calculating a range of acceptable metric values, generating graphics that represent the range of acceptable metrics values, and generating a graphic that depicts the real-time values of those metrics overlaid with the range of acceptable metrics values. 126-. (canceled)27. A method for monitoring radiotherapy , the method comprising:(a) acquiring imaging data during a radiotherapy treatment session;(b) calculating a dosimetric objective value using the acquired imaging data, wherein the dosimetric objective value represents a delivered radiation dose;(c) comparing the dosimetric objective value with a range of acceptable dosimetric objective values; and(d) generating a notification that indicates whether the dosimetric objective value is within the range of acceptable dosimetric objective values.28. The method of claim 27 , further comprising pausing radiation delivery in the treatment session if the dosimetric objective value is outside the range of acceptable dosimetric objective values.29. The method of claim 27 , wherein the imaging data comprises one or more of PET detector data claim 27 , X-ray detector data claim 27 , MM detector data claim 27 , ultrasound transducer data claim 27 , and optical camera data.30. The method of claim 27 , wherein the dosimetric objective value comprises one or more of a minimum percent volume at a selected dose level claim 27 , ...

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Номер записи: 92

06-01-2022 дата публикации

QUALITY ASSURANCE FOR MR-LINAC

Номер: US20220001210A1

Автор: Conneely Elaine, Letourneau Daniel

Принадлежит:

The present disclosure includes procedures to automate quality assurance testing for radiotherapy equipment that includes MR-Linac devices that are agnostic as to the manufacturer and vendor of the equipment. The present disclosure includes a process for performing a validation procedure for the linear accelerator of the MR-Linac device. The present disclosure includes a process for analyzing quality of the images produced by the MR imaging device of the MR-Linac device. The present disclosure includes a process for combining performance of a validation procedure for the linear accelerator of the MR-Linac device and the analysis of the quality of the images produced by the MR imaging device of the MR-Linac device. 1. A method for validating an operation of a radiotherapy apparatus comprising an integrated linear accelerator and MRI imaging device (MR-Linac) , the method comprising:selecting a validation procedure associated with the linear accelerator of the MR-Linac;retrieving, based on the selected validation procedure, configuration information for a multi-leaf collimator (MLC) of the MR-Linac;obtaining a plurality of images from an imaging detector each associated with given radiation beam of a plurality of radiation beams that passes through the MLC that has been adjusted based on the configuration information;processing the plurality of images to determine a characteristic of the MR-Linac; anddetermining whether the MR-Linac is operating within a valid range based on processing of the plurality of images.2. The method of further comprising comparing the determined characteristic with an allowable threshold associated with the selected validation procedure and adjusting one or more characteristics of the MR-Linac in response to determining that the MR-Linac is operating outside of the valid range.3. The method of claim 2 , wherein the one or more characteristics are determined based on the selected validation procedure.4. The method of claim 1 , further ...

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Номер записи: 93

02-01-2020 дата публикации

DEVICE FOR REPEATABLE HEAD AND NECK TUMOR ALLOCATION DURING ONCOLOGY RADIATION THERAPY

Номер: US20200000544A1

Автор: Chen Jie, LuLu Bruce, Shapiro Ronald Howard

Принадлежит:

A device for accurately locate the tumor in a radiation therapy machine (RTM) based on the patient's CT image is disclosed. The device immobilizes a patient in a repeatable location when a CT scan is made and the radiation therapy is given. The device includes a base plate to support the patient, on which there are: a pair of pins to constrain the armpits of the patient, a pair of shoulder pads to constrain the shoulders of the patient, a headrest and head pads to constrain the head of the patient, markers, and a jaw restrainer secured to the head pads. Coordinate transformations will be used to locate the tumor in the RTM. 1. A device for immobilizing a patient in a repeatable location , comprising:a base plate configured to support the patient;a pair of pins configured to lock after constraining armpits of the patient;a pair of shoulder pads configured to lock after constraining shoulders of the patient;a headrest configured to constrain rotation of a back side of a head of the patient;a plurality of head pads configured to lock after constraining the head;at least three markers configured to be placed on the base plate; anda jaw restrainer configured to be secured to the pair of head pads.2. The device of claim 1 , further comprising a frame configured to support a removable probe with a laser pointer operable to align the head to a centerline of the base plate.3. The device of claim 1 , further comprising:a first indexed dial mechanically coupled to the pair of pins, the first indexed dial configured to control movement of the pins and lock after constraining the armpits; anda second indexed dial mechanically coupled to the head pads, the second indexed dial configured to control movement of the head pads and lock after constraining the head.4. A system for radiotherapy claim 1 , comprising:a scanner for scanning a body of a patient for at least one tumor; a pair of pins configured to lock after constraining armpits of the patient,', 'a pair of shoulder pads ...

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Номер записи: 94

03-01-2019 дата публикации

TREATMENT WITH ANGIOGENIN TO ENHANCE HEMATOPOIETIC RECONSTITUTION

Номер: US20190000885A1

Автор: GONCALVES Kevin, Hu Guo-fu, Kharchenko Peter, SCADDEN David, Silberstein Lev

Принадлежит:

Aspects of the technology disclosed herein generally (and in part) relates to use of Angiogenin (ANG) for increasing hematopoietic reconstitution of in vivo hematopoietic cells and transplanted hematopoietic cells. Provided herein are methods and compositions useful in treatment of diseases characterized by decreased levels of hematopoietic cells, decreased levels of hematopoietic reconstitution, blood cell deficiency and prevention and treatment of radiation injury. One aspect relates to angiogenin treated hematopoietic cell compositions and methods of their use in stem cell transplantation. Treatment of hematopoietic cells with angiogenin enhances quiescence and reduces proliferative capacity of primitive hematopoietic stem cells while increasing proliferation of myeloid restricted progenitor cells. Another aspect relates to use of ANG in prophylactic and therapeutic treatment methods for radiation injury. 127.-. (canceled)28. A method for expanding a population of hematopoietic cells in a biological sample , the method comprising contacting the population of hematopoietic cells with an Angiogenin (ANG) protein or ANG agonist , wherein the population comprises primitive hematopoietic stem cells and myeloid restricted progenitors , and wherein the contacting is for a sufficient amount of time to allow for primitive hematopoietic stem cells quiescence and myeloid restricted progenitor proliferation.29. The method of claim 28 , wherein the primitive hematopoietic stem cells are selected from the group of: long-term hematopoietic stem cells (LT-HSCs) claim 28 , short-term hematopoietic stem cells (ST-HSCs) claim 28 , multipotent progenitors (MPPs) or a combination thereof.30. The method of claim 28 , wherein the myeloid restricted progenitor are selected from the group of: common myeloid progenitors (CMPs) claim 28 , common lymphoid progenitors (CLPs) claim 28 , granulocyte-macrophage progenitors (GMPs) and megakaryocyte-erythroid progenitors (MEPs) or a combination ...

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Номер записи: 95

07-01-2016 дата публикации

Skin patch dosimeter

Номер: US20160001094A1

Автор: John ISHAM

Принадлежит: RadiaDyne LLC

A skin patch sensor having a groove therein to receive a sensor without leaving any air pockets is described. The skin patch sensor also has a water or tissue equivalent material and/or, in some embodiments, a moldable water equivalent material.

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Номер записи: 96

02-01-2020 дата публикации

Bismuth-Gadolinium Nanoparticles

Номер: US20200000915A1

Автор: Berbeco Ross, Detappe Alexandre, Duc Geraldine Le, Lux François, Thomas Eloise, Tillement Olivier

Принадлежит:

Provided herein are nanoparticle compositions (e.g., nanoparticle compositions comprising high atomic number ions) that are useful for imaging diseases in a subject as well as radiosensitizing a disease in a subject (e.g., radiosensitizing a cancer in the subject). Methods of imaging a subject, methods of treating cancer, and processes of preparing the nanoparticle compositions are also provided. 1. A composition , comprising:a nanoparticle core comprising one or more first linking groups covalently bonded to a first ligand and one or more second linking groups covalently bonded to a second ligand;{'sup': 3+', '3+, 'wherein one or more of the first ligands are complexed to Gd ions and one or more of the second ligands are complexed to Bi ions.'}2. The composition of claim 1 , wherein the nanoparticle core is a silica core.3. The composition of claim 1 , wherein the nanoparticle core is a polysiloxane core.4. The composition of any one of to claim 1 , wherein the one or more first linking groups each comprise a Calkylamine covalently bonded to the first ligand.5. The composition of any one of to claim 1 , wherein each of the first ligands is independently selected from the group consisting of 1 claim 1 ,4 claim 1 ,7-triazacyclononanetriacetic acid (NOTA) claim 1 , 1 claim 1 ,4 claim 1 ,7 claim 1 ,10-tetraazacyclododecane-1 claim 1 ,4 claim 1 ,7 claim 1 ,10-tetraacetic acid (DOTA) claim 1 , 1 claim 1 ,4 claim 1 ,7-triazacyclononane-1-glutaric acid-4 claim 1 ,7-diacetic acid (NODAGA) claim 1 , ethylene diamine tetra-acetic acid (EDTA) claim 1 , diethylene triaminepentaacetic acid (DTPA) claim 1 , cyclohexyl-1 claim 1 ,2-diaminetetraacetic acid (CDTA) claim 1 , ethyleneglycol-O claim 1 ,O′-bis(2-aminoethyl)-N claim 1 ,N claim 1 ,N′ claim 1 ,N′-tetraacetic acid (EGTA) claim 1 , N claim 1 ,N-bis(hydroxybenzyl)-ethylenediamine-N claim 1 ,N′-diacetic acid (MED) claim 1 , triethylene tetramine hexaacetic acid (TTHA) claim 1 , hydroxyethyidiamine triacetic acid (HEDTA) claim ...

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Номер записи: 97

07-01-2021 дата публикации

METHOD FOR LIGHT TREATMENT PLANNING USING LOCATION-INFORMED MODELS

Номер: US20210001149A1

Автор: LaRochelle Ethan Phillip M., Pogue Brian W.

Принадлежит:

In an embodiment, the present disclosure pertains to a method of determining optimal parameters for application of light from a light source to a tissue. In general, the method includes one or more of the following steps of: (1) utilizing an algorithm to generate results related to estimating light flow from the light source into the tissue; and (2) utilizing the results to determine optimal parameters for applying the light source to the tissue. In some embodiments, the method of the present disclosure further includes the step of: (3) applying the light source to the tissue using the optimal parameters; and (4) treating a condition associated with the tissue. 1. A method of determining optimal parameters for application of light from a light source to a tissue , said method comprising:utilizing an algorithm to generate results related to estimating light flow from the light source into the tissue; andutilizing the results to determine optimal parameters for applying the light source to the tissue.2. The method of claim 1 , wherein the algorithm is selected from the group consisting of a Monte Carlo model claim 1 , a broad-spectrum light fluence model claim 1 , a Monte Carlo model of broad-spectrum light fluence claim 1 , optical radiative transport models claim 1 , optical diffusion models claim 1 , and combinations thereof.3. The method of claim 1 , wherein the algorithm comprises a seven-layer skin model comprising at least one of stratum corneum layers claim 1 , living epidermis layers claim 1 , papillary dermis layers claim 1 , upper blood net dermis layers claim 1 , reticular dermis layers claim 1 , deep blood dermis layers claim 1 , and subcutaneous fat layers.4. The method of claim 1 , wherein the algorithm utilizes at least one factor to estimate the light flow claim 1 , wherein the at least one factor is selected from the group consisting of type of the light source claim 1 , position of the light source claim 1 , light fluence from the light source claim ...

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Номер записи: 98

07-01-2021 дата публикации

PROTON-ARC BEAM DELIVERY SYSTEM

Номер: US20210001150A1

Автор: Schippers Jacobus Maarten

Принадлежит:

A particle beam therapy system delivers a particle beam for particle radiation therapy to a target volume in a patient from different treatment angles. The particle beam enters an active static magnetic field region perpendicularly to a magnetic field. Magnets and/or coils generate a cylindrically shaped magnetic field system with magnetic fields oriented axially in the magnetic field system. The active magnetic field region has an outer radial guiding field region and an inner radial bending field region, with an arc scan magnet system at an outer edge, a first number of coils generating a static magnetic guiding field that is predominantly effective in the outer radial guiding field region, and a second number of coils predominantly effective in an inner radial bending field region. A treatment control system controls the magnets and/or coils to guide the particle beam according to a treatment plan for the target volume of the patient. 16-. (canceled)7. A particle beam therapy system with a configuration of magnetic fields for delivering a particle beam for particle radiation therapy to a target volume in a patient from different treatment angles , the system comprising:a) a particle beam directed towards an active static magnetic field region, a direction of the particle beam incoming into said magnetic field region being substantially perpendicular to a direction of a magnetic field in said magnetic field region;b) said active static magnetic field region having a plurality of magnets and/or coils disposed to generate a cylindrically shaped magnetic field system filled with magnetic fields that are oriented substantially in an axial direction of said cylindrically shaped magnetic field system, said magnetic field region including an outer radial guiding field region and an inner radial bending field region; c1) an arc scan magnet system located at an outer edge of said cylindrically shaped magnetic field system; said arc scan magnet system effecting a radial ...

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Номер записи: 99

07-01-2021 дата публикации

NEUTRON CAPTURE THERAPY SYSTEM

Номер: US20210001151A1

Автор: Liu Yuan-Hao

Принадлежит:

A neutron capture therapy system includes a neutron beam generating unit, an irradiation room configured to irradiate an irradiated body with a neutron beam, a preparation room configured to implement preparation work required to irradiate the irradiated body with the neutron beam, and an auxiliary positioner disposed in the irradiation room and/or the preparation room. The irradiation room includes a first shielding wall, a collimator is disposed on the first shielding wall for emitting the neutron beam, the neutron beam is emitted from the collimator and defines a neutron beam axis. The auxiliary positioner includes a laser emitter that emits a laser beam to position the irradiated body. Wherein the position of the laser emitter is selectable. Therefore, the irradiated body can be positioned in any case to implement precise irradiation. 1. A neutron capture therapy system , comprising:an irradiation room configured to irradiate an irradiated body with a neutron beam, wherein the irradiation room comprises a first shielding wall and a collimator disposed on the first shielding wall for emitting the neutron beam, and wherein the neutron beam is emitted from the collimator and defines a neutron beam axis,a preparation room configured to implement preparation work required to irradiate the irradiated body with the neutron beam, andan auxiliary positioner disposed in the irradiation room and/or the preparation room, wherein the auxiliary positioner comprises a laser emitter for emitting a laser beam to position the irradiated body, and wherein a position of the laser emitter is selectable.2. The neutron capture therapy system according to claim 1 , wherein the auxiliary positioner comprises a base and a cantilever extending perpendicularly from the base claim 1 , and the laser emitter is disposed on the cantilever.3. The neutron capture therapy system according to claim 2 , wherein the cantilever is provided with a guiderail for guiding the laser emitter to move and a ...

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Номер записи: 100

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