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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 1182. Отображено 100.
11-10-2012 дата публикации

Annular electrode array

Номер: US20120259388A1
Автор: Pedro Galvan-Garcia
Принадлежит: Individual

A three-dimensional annular electrode array (AEA) device is disclosed for use as a cybernetic neural interface for the neural control and sensory feedback of a bionic prosthetic device. The AEA, designed for implantation into a nerve, is comprised of a body ( 6 ) that can be coupled to a sleeve(s) ( 9, 10 ) or a sleeve(s) with a compartmentalized inner core ( 12 ) for connection to the proximal and distal ends of a transected nerve, respectively. Regenerating nerve axons capture and sequester laterally projecting electrode terminals ( 4 ) arranged in radiating clusters ( 5 ) of a plurality of electrode sub-array nodes ( 2 ) that make up the array; connected by a primary electrode lead ( 7 ) to a connector contact array ( 3 ) in a plurality of connectors ( 1 ) for connection to wired or wireless electromechanical systems.

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Номер записи: 1
28-02-2013 дата публикации

Dipole electrical stimulation employing direct current for recovery from spinal cord injury

Номер: US20130053922A1
Автор: Andrzej Wieraszko, Zaghloul Ahmed
Принадлежит: Individual

A system and method to treat neuromuscular conditions, including spinal cord injury, by what is characterized as dipole (two point) cortico-muscular stimulation. Two-point stimulation, with oppositely charged electrodes, allows pulsed, direct current to pass through the cortico-muscular pathway. The electrodes are placed on nerves, muscles, or a combination of both, that are on opposite sides of the spinal column, forming a current that passes across the spinal column. Further, an active electrode can be placed on the spinal column and a reference electrode can be placed outside the central nervous system. These methods improve functional recovery of the motor pathway.

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Номер записи: 2
07-03-2013 дата публикации

Neural prosthesis and method for producing a neural prosthesis

Номер: US20130060266A1
Автор: Georg Bretthauer, Selman Uranues
Принадлежит: Karlsruher Institut fuer Technologie KIT, MEDIZINISCHE UNIVERSITAET GRAZ

The invention relates to a neural prosthesis, a neural prosthesis for use in the treatment of severed nerves and to a method for producing a neural prosthesis. Said neural prosthesis comprises a coupling element receptacle and at least one coupling element having a first and a second coupling section, wherein the coupling element is fixed by the coupling element receptacle, and wherein the first coupling section can be arranged on a first nerve region and the second coupling section on a second nerve region so that both nerve regions can be coupled by means of the neural prosthesis.

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Номер записи: 3
06-06-2013 дата публикации

FLEXIBLE-BASE ELECTRODE ARRAY AND SURROGATE NEURAL TISSUE

Номер: US20130144369A1
Автор: Cheng Cheng, Elias Anastasia, Khaled Imad, Moussa Walied, Mushawar Vivian, Todd Kathryn
Принадлежит: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA

A flexible-base electrode array for implantation within neural tissue, method of making the electrode array and use thereof, is provided. A surrogate neural tissue, method of making same and use thereof, is further provided. The use of the present flexible-base electrode array for implantation into the surrogate neural tissue for stimulation or recording neural activity, wherein the array is biocompatible with the surrogate tissue. 1. An electrode array for implantation in a target neural tissue , comprising:a. a flexible base, andb. at least one electrode protruding from the base,for implantation into and biocompatible with the target tissue.2. The array of claim 1 , wherein the base comprises a plurality of rows having at least one electrode.3. The array of claim 2 , wherein the base comprises two rows of at least one electrode.4. The array of claim 1 , wherein the flexibility of the base is equal to or greater than the target neural tissue.5. The array of claim 1 , wherein the array is made of a biocompatible polymer.6. The array of claim 5 , wherein the array is made of polydimethylsiloxane (PDMS).7. The array of claim 5 , wherein the array is made of silicone elastomer.8. The array of claim 7 , wherein the silicone elastomer is MED 6215.9. The array of claim 1 , wherein the base further comprises a temporary handle.10. The array of claim 1 , wherein the target tissue is brain or spinal cord.11. A method of fabricating the flexible-base electrode array of .12. Use of the flexible-base electrode array of for stimulating or recording electrical activity in the target tissue.13. The use of the flexible-base electrode array of claim 12 , wherein the target tissue is brain or spinal cord.14. The use of the flexible-base electrode array of claim 12 , for intraspinal microstimulation.15. The use of the flexible-base electrode array of claim 14 , wherein the use is long term.16. A surrogate neural tissue capable of receiving an implantable array of microelectrodes.17. ...

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Номер записи: 4
22-08-2013 дата публикации

STIMULATION SIGNAL GENERATION DEVICE AND STIMULATION SIGNAL GENERATION METHOD

Номер: US20130218238A1
Автор: Kato Ryu, Morishita Soichiro, Nakamura Tatsuhiro, Yamamura Osamu, Yokoi Hiroshi
Принадлежит: THE UNIVERSITY OF ELECTRO-COMMUNICATIONS

Implementation including a brain activity data acquisition unit () configured to acquire data on brain activity of a human body; a generator () configured to generate a stimulation signal based on predetermined stimulation parameters or stimulation parameters determined from the data acquired by the brain activity data acquisition unit, the stimulation signal being to be applied, for activity of a specific brain region to be activated in order to move a joint of the human body, to a nerve corresponding to the specific brain region; and an output unit () configured to output the stimulation signal generated by the generator. 1. A stimulation signal generation device for generating a stimulation signal to be used to assist exercise of a human body , comprising:a generator configured to, during preprocessing, generate a stimulation signal based on preprocessing stimulation parameters predetermined for the preprocessing, the stimulation signal to be applied to both an afferent neuron and an efferent neuron of nerve of the human body, corresponding to a specific brain region to be activated in order to move a joint of the human body, and configured to, during assist processing, generate the stimulation signal to be applied for the activity of the specific brain region, based on assist-processing stimulation parameters inputted to the generator;an output unit configured to output the stimulation signal generated by the generator, to stimulation pads attached in the vicinity of the joint of the human body and configured to apply stimulation through the skin to both the afferent neuron and the efferent neuron;a brain activity data acquisition unit configured to acquire data on activity of a brain under application of the stimulation by the stimulation signal outputted by the output unit; anda decision unit configured to obtain a set of optimum stimulation parameters from the data acquired by the brain activity data acquisition unit, to use the set of optimum stimulation ...

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Номер записи: 5
12-09-2013 дата публикации

NEUROMODULATION USING ENERGY-EFFICIENT WAVEFORMS

Номер: US20130238059A1
Автор: CARLTON Keith, GRESZLER Alan, Kokones Scott, YORK Randall
Принадлежит: INTELECT MEDICAL INC.

Methods of neuromodulation in a live mammalian subject, such as a human patient. The method comprises applying an electrical signal to a target site in the nervous system, such as the brain, where the electrical signal comprises a series of pulses. The pulses includes a waveform shape that is more energy-efficient as compared to a corresponding rectangular waveform. Non-limiting examples of such energy-efficient waveforms include linear increasing, linear decreasing, exponential increasing, exponential decreasing, and Gaussian waveforms. Also described are apparatuses for neuromodulation and software for operating such apparatuses. 126-. (canceled)27. A neuromodulation method comprising: the electrical signal comprises a first phase and a second phase immediately following the first phase;', 'the electrical signal is anodic in one of the first and second phases and cathodic in the other of the first and second phases;', 'a waveform of the electrical signal in each of the first and second phases is entirely defined by one of an exponential increasing function and an exponential decreasing function., 'applying an electrical signal to an anatomical site, wherein28. The neuromodulation method of claim 27 , wherein the waveforms of the electrical signal in the first and second phases are substantially mirror images of each other.29. The neuromodulation method of claim 27 , wherein the waveform represents current amplitude of the signal over time.30. The neuromodulation method of claim 27 , wherein the waveform represents voltage amplitude of the signal over time.31. The neuromodulation method of claim 27 , wherein the anatomical site is a brain site.32. The neuromodulation method of claim 31 , wherein the brain site is involved in motor function.33. The neuromodulation method of claim 31 , wherein the brain site is the thalamus or subthalamic nucleus.34. A neuromodulation method comprising:executing, by an electrical signal generator, a program defining a function to ...

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Номер записи: 6
26-09-2013 дата публикации

MONITORING AND REGULATING PHYSIOLOGICAL STATES AND FUNCTIONS VIA SENSORY NEURAL INPUTS TO THE SPINAL CORD

Номер: US20130253299A1
Автор: Bruns Timothy, Gaunt Robert, Weber Douglas
Принадлежит: University of Pittsburgh - of the Commonwealth System of Higher Education

Methods and apparatuses for monitoring and regulating physiological states and functions are disclosed. Several embodiments include application of one or more microelectrode arrays to a dorsal root ganglion for measurement of sensory neuron activity, or stimulation of sensory reflex circuits. The methods and apparatuses can be used, for example, for monitoring or controlling bladder function in a patient. 1. A method of monitoring a physiological state of an organ or a tissue in a patient , comprising contacting at least one dorsal root ganglion in the patient with a microarray , wherein the microarray comprises a plurality of individual electrodes , the method further comprising a calibration phase and a monitoring phase , wherein: measuring sensory neuron activity with the individual electrodes; and', 'correlating the sensory neuron activity measured with the individual electrodes in the array with the physiological state of the organ or the tissue in the patient to identify individual electrodes in the array that measure the sensory neuron activity associated with the physiological state; and, '(A) the calibration phase comprises measuring the sensory neuron activity associated with the physiological state with the identified individual electrodes; and', 'outputting an indication of the physiological state of the organ or the tissue to an effector, a user interface, a computer readable storage medium, and/or a local or remote computer system, to monitor the physiological state of the organ or the tissue in the patient., '(B) the monitoring phase comprises2. The method of claim 1 , wherein the microarray penetrates the dorsal root ganglion.3. The method of claim 1 , wherein the microarray is closely coupled to the surface of the dorsal root ganglion.4. The method of claim 1 , wherein the effector is a neuroprosthesis claim 1 , an orthosis claim 1 , an exoskeleton claim 1 , an assistive device claim 1 , or a drug pump.5. The method of claim 1 , wherein the user ...

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Номер записи: 7
31-10-2013 дата публикации

Enhanced therapeutic stimulus system and methods of use

Номер: US20130289648A1
Автор: David L. Stalling, Kenneth Aron, Steven M. Barlow
Принадлежит: Individual

The present invention relates to a therapeutic system and methods of using the therapeutic system. In particular, the present invention relates to systems having hardware, software, and appliance components for assessing and entraining a neuromuscular pattern or behavior in a patient. The methods include configuring the hardware and software systems to receive data from an orofacial stimulation appliance and to generate a precise therapeutic pulse profile that is actuated as a tactile stimulus. In one embodiment, the system and methods also include collecting data using the orofacial stimulation appliance and delivering the tactile stimulus via the orofacial stimulation appliance to entrain an organized neuromuscular pattern or behavior.

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Номер записи: 8
16-01-2014 дата публикации

BRAIN REPAIR USING ELECTRICAL STIMULATION OF HEALTHY NODES

Номер: US20140018882A1
Автор: Andersen Richard A., Kagan Igor, Wilke Melanie
Принадлежит:

A method and system of compensating for a damaged brain node is disclosed. The damaged node is determined by techniques such as fMRI or neural recording. A healthy node that can compensate for the function of the damaged node is determined. A stimulating electrode is placed on at least one functioning node to bypass the activity from the damaged node to compensate for a missing node. The functioning node is then stimulated to compensate for the damaged node. 1. A method of brain repair of a damaged node , comprising:determining the location of a damaged node within a brain circuit;determining at least one functioning node to compensate for the damaged node within the brain circuit;placing a stimulator on the brain on the at least one functioning node to bypass the activity from the damaged node to compensate for a missing node; andstimulating the at least one functioning node to compensate for the damaged node.2. The method of claim 1 , wherein the stimulator placement is performed using functional magnetic resonance imaging studies.3. The method of claim 1 , wherein the stimulator placement is performed using studies of similar deficits.4. The method of claim 1 , wherein the stimulator placement is performed using neural recording studies.5. The method of claim 1 , wherein the stimulator provides a constant stimulus.6. The method of claim 1 , wherein the brain circuit is damaged from a neurological deficit.7. The method of claim 6 , wherein the neurological deficit is neglect claim 6 , the brain circuit is the parietal lobe claim 6 , the damaged node is the posterior parietal cortex node and the functioning node is the pulvinar.8. The method of claim 6 , wherein the neurological deficit is apraxia claim 6 , the brain circuit is the parietal node claim 6 , the damaged node is the anterior intraparietal area and the functioning node is the ventral premotor cortex.9. The method of claim 6 , wherein the neurological deficit is hemianesthesia claim 6 , the brain circuit ...

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Номер записи: 9
06-02-2014 дата публикации

METHOD AND DEVICE TO RESTORE AND/OR IMPROVE NERVOUS SYSTEM FUNCTIONS BY MODIFYING SPECIFIC NERVOUS SYSTEM PATHWAYS

Номер: US20140039571A1
Автор: Brunner Peter, CHEN Xiang Yang, McFARLAND Dennis J., Schalk Gerwin, THOMPSON Aiko K., WOLPAW Jonathan R.
Принадлежит: Health Research, Inc.

The present invention provides methods, devices, and systems for restoring or improving nervous system function of a subject. Provided is a method involving: (i) providing an operant conditioning protocol effective to produce targeted neural plasticity (TNP) in a primary targeted central nervous system (CNS) pathway of a subject; and (ii) administering the operant conditioning protocol to the subject to elicit TNP in the primary targeted CNS pathway and to elicit generalized neural plasticity (GNP) in one or more other CNS pathway. The elicitation of the GNP in the one or more other CNS pathway serves to restore or improve a nervous system function of the subject. Provided is a device comprising a nerve stimulation-electromyographic recording component and a controller for operating the nerve stimulation-electromyographic recording component in accordance with an operant conditioning protocol. 1. A method for restoring or improving nervous system function of a subject , said method comprising:providing an operant conditioning protocol effective to produce targeted neural plasticity (TNP) in a primary targeted central nervous system (CNS) pathway of a subject; andadministering the operant conditioning protocol to the subject under conditions effective to elicit TNP in the primary targeted CNS pathway and to elicit generalized neural plasticity (GNP) in one or more other CNS pathways,wherein the elicitation of the GNP in the one or more other CNS pathway serves to restore or improve a nervous system function of the subject.2. The method according to claim 1 , wherein the operant conditioning protocol is self-administered by the subject.3. The method according to claim 1 , wherein the operant conditioning protocol is designed to down-condition hyperactive reflexes in the subject claim 1 , up-condition hypoactive reflexes in the subject claim 1 , and/or up-condition or down-condition other CNS pathways.4. The method according to claim 1 , wherein the primary targeted ...

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Номер записи: 10
20-03-2014 дата публикации

Methods and apparatus for renal neuromodulation

Номер: US20140081259A1
Автор: Denise Zarins, Douglas Sutton, Erik Thai, Hanson Gifford, III, Howard R. Levin, Mark E. Deem, Mark Gelfand
Принадлежит: Medtronic Ardian Luxembourg SARL

Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for percutaneous intravascular delivery of pulsed electric fields to achieve such neuromodulation.

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Номер записи: 11
02-01-2020 дата публикации

ELECTRIC BIOPOTENTIAL SIGNAL MAPPING CALIBRATION, ESTIMATION, SOURCE SEPARATION, SOURCE LOCALIZATION, STIMULATION, AND NEUTRALIZATION.

Номер: US20200000355A1
Автор: Khair Mohammad Mohammad
Принадлежит:

A leadless wireless ECG measurement system for measuring of bio-potentials includes at least one multi-contact bio-potential electrode assembly adapted for attachment to the patient's body to measure ECG. A processing unit is configured to produce a transfer function which computes estimated long-lead ECG signals based on the measured short-lead ECG signals from the plurality of contact points. This invention describes calibration process of short-lead ECG with standard lead ECG without requiring use of lead wires, only using a flexibly moving body part (finger) to calibrate patch. The invention describes use of algorithms for biopotential signal separation from mixed sources. The invention describes use of signal separation for identification of abnormal signals and the localization of biopotential source tissue. This invention describes effective biopotential evoked potential stimulation. The invention also describes biopotential neutralization of undesired biopotential. 1. A biopotential measurement and calibration system for leadless electrocardiographic (ECG) measurement of electrical activity of the heart in a subject's body , the system comprising:at least one multi-contact bio-potential electrode assembly adapted for attachment to the subject's body, said electrode assembly being formed of an electronic layer and an electrode layer;said electrode layer having a plurality of contact points for engagement with the surface of the subject's body and configured to measure short-lead ECG signal(s) in response to electrical activity of the heart;a calibration probe having an interior conductive surface and an exterior conductive surface, wherein said calibration probe is capable of sensing one or more ECG biopotential calibration long leads when (1) said interior conductive surface is in contact with a patient's finger or wrist, and (2) said exterior conductive surface is in contact with patient's body; anda processing unit configured to produce a transfer function ...

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Номер записи: 12
06-01-2022 дата публикации

LEAD PLACEMENT FOR NERVE STIMULATION

Номер: US20220001176A1
Автор: Agran Jason E., Dinsmoor David A., Su Xin
Принадлежит:

Example systems for positioning an implantable electrode may include a stimulation circuitry, a sensing circuitry, and processing circuitry. The stimulation circuitry may generate electrical stimulation deliverable to a patient. The sensing circuitry may sense electromyographic (EMG) responses. The processing circuitry may control the stimulation circuitry to deliver the electrical stimulation at a plurality of different stimulation metric levels at each of a plurality of different positions. The processing circuitry may sense, via the sensing circuitry, electromyographic (EMG) responses to the electrical stimulation. The processing circuitry may score one or more of the different positions for chronic implantation of at least one implantable electrode. The scoring may be based on a stimulation metric level greater than a predetermined metric threshold sufficient to evoke at least some of the sensed EMG responses, and a level of the at least some of the sensed EMG responses. 1. A system comprising:a stimulation circuitry configured to generate electrical stimulation deliverable to a patient;sensing circuitry configured to sense electromyographic (EMG) responses from the patient; and control the stimulation circuitry to deliver, via at least one electrode, the electrical stimulation at a plurality of different stimulation metric levels at each of a plurality of different positions within the patient;', 'sense, via the sensing circuitry, electromyographic (EMG) responses from the patient to the electrical stimulation, and', at least one stimulation metric level of the plurality of different stimulation metric levels greater than a predetermined metric threshold sufficient to evoke at least some of the sensed EMG responses to the delivery of the electrical stimulation at a respective position of the one or more positions, and', 'a level of the at least some of the sensed EMG responses produced in response to the delivery of the electrical stimulation at the at least ...

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Номер записи: 13
03-01-2019 дата публикации

SYSTEM AND METHOD FOR TRANSCRANIAL CURRENT LOOP BRAIN STIMULATION

Номер: US20190001142A1
Автор: PHILLIPS James William
Принадлежит:

A method and device is described, which provides electrical stimulation to the brain of a person, where the device comprises an external portion and at least one implantable portion. The external portion provides the energy source for stimulation to the implantable portions. The implantable portions provide at least two conductive paths through the skull and use the skull's high impedance to generate a current loop with the focus of stimulation lying in the current path. 1. A method for electrically stimulating a brain of a person , said method comprising: creating at least two conductive paths through the skull; and generating a current flow through said paths , wherein the current flows from a first of the conductive paths to a second of the conductive paths through a further path exterior of the skull and flows back from the second of the conductive paths to the first of the conductive paths through at least one stimulation target in the brain.2. The method of wherein current flow is generated internally in the body of the person.3. The method of wherein current flow is generated externally of the body of the person.4. The method of wherein the current flow is generated by bringing an energy source on or near the scalp of the person and activating the energy source.5. The method of wherein the current flow is generated by rotating at least one permanent magnet in at least one external portion.6. The method of wherein the current flow is generated by sending electric current through at least one conductive coil in at least one external portion.7. The method of wherein the device is used for the treatment of at least one of epilepsy claim 1 , Parkinson's disease claim 1 , migraine claim 1 , fibromyalgia claim 1 , and stroke rehabilitation.8. The method of further comprising selecting a patient at risk of suffering an epileptic seizure and treating the patient when the person experiences an “aura” associated with an epileptic episode.9. The method of further ...

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Номер записи: 14
12-01-2017 дата публикации

Method and means to improve the effects of electrical cell and neuron stimulation with random stimulation in both location and time

Номер: US20170007828A1
Автор: Monteiro Sergio Lara Pereira
Принадлежит:

An electric stimulator for brain, heart, skin and internal organs in animals and plants where the electrodes are distributed on a supporting structure. The supporting structure may be adapted for brain, heart, skin or other internal organs, as for DBS, heart pacemaker, TENS, etc. The invention discloses a plurality of electrodes at the surface of the supporting structure, from which electrically stimulating currents can be injected into the organism. Turning off an electrode while turning on another electrode has the effect of moving the stimulation within the body of the organism from one point to another point, with the same effect but with less spent energy than physically moving the whole electrode support. We call this electrode shifting. Rotational and translational electrode shifting are possible. The invention also discloses random changes of the electrode shifting, and random changes of the stimulation time and of the stimulation duration. 1. A method of adjusting the location of an electrical stimulation caused by an electrical stimulator configured to be implanted in an animal comprising:providing a supporting structure configured to be attached to the animal;providing an electrode supporting structure with a proximal extremity, a distal extremity, a surface and an inner volume;providing a plurality of pads or electrodes at the surface of the electrode supporting structure;providing one or more electronic controlling unit which is configured to change the state of some of the electrodes from on to off and/or from off to on at different times or to leave the state of some of the electrodes unchanged,providing electrically connecting means connecting the electrodes at the surface of the electrode supporting structure to the one or more electronic controlling unit wherein,{'b': 1', '2', '1', '1', '3', '1', '3, 'the one or more electronic controlling unit is configured for providing a change in the electrodes that are turned on providing electrical ...

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Номер записи: 15
11-01-2018 дата публикации

SYSTEMS, METHODS, AND DEVICES FOR EVALUATING LEAD PLACEMENT BASED ON GENERATED VISUAL REPRESENTATIONS OF SACRUM AND LEAD

Номер: US20180008834A1
Автор: Iyassu Yohannes, Kaula Norbert, Siegel Steven
Принадлежит:

A method of evaluating an implantation of a lead is disclosed. Via a graphical user interface of an electronic device, a visual representation of a sacrum of the patient and a lead that is implanted in the sacrum is displayed. The lead includes a plurality of electrode contacts. An evaluation is made as to how well the lead has been implanted in the sacrum based on the visual representation of the sacrum and the lead. The evaluating comprises: determining whether the lead is inserted in a predetermined region of the sacrum, determining how far a predetermined one of the electrode contacts is located from an edge of the sacrum, and determining a degree of curvature of the lead. 1. A method of evaluating an implantation of a lead that is configured to deliver electrical stimulation to a patient , the method comprising:obtaining visual representations of a sacrum of the patient and the lead that is implanted in the sacrum; and a first factor involving which foramen of the sacrum the lead is implanted in;', 'a second factor involving how far the lead is coming out of a pelvic floor of the patient; or', 'a third factor involving how bent the lead is., 'evaluating a placement of the lead by analyzing the visual representations of the sacrum and the lead to determine whether one or more of the following factors are met2. The method of claim 1 , wherein the first factor is met if the lead is implanted in an S3 foramen of the sacrum.3. The method of claim 1 , wherein the second factor is met if a last contact of the lead is located proximate to the pelvic floor.4. The method of claim 1 , wherein the third factor is met if a curvature of the lead conforms to a predetermined curvature range.5. The method of claim 1 , further comprising: communicating a result of the evaluating to a user.6. The method of claim 1 , wherein the obtaining comprises:receiving one or more fluoroscopy images of the patient; andconstructing the visual representations by digitally processing the one or ...

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Номер записи: 16
10-01-2019 дата публикации

System and Method of Performing Computer Assisted Stimulation Programming (CASP) With a Non-Zero Starting Value Customized to a Patient

Номер: US20190009092A1
Автор: Iyassu Yohannes, Kaula Norbert
Принадлежит:

A non-zero starting value for ramping up a stimulation parameter for an electrical stimulation to be delivered to a patient is determined. The non-zero starting value is customized to the patient. A pulse generator is caused to generate the electrical stimulation, which is delivered to the patient via an implanted lead. The pulse generator is caused to ramp up, from the determined non-zero starting value and toward a predefined maximum limit value, the stimulation parameter for a plurality of electrode contacts on the lead. Feedback is received from the patient in response to the ramping up. The feedback is received via an electronic patient feedback device. Based on the ramping up and the received feedback from the patient, a perception threshold is determined for each of the plurality of electrode contacts. The perception threshold is a value of the stimulation parameter that corresponds to the patient feeling the electrical stimulation. 120-. (canceled)21. A method , comprising:increasing a stimulation parameter of an electrical stimulation that is applied to a patient via a lead having one or more electrodes located thereon, wherein the stimulation parameter includes stimulation amplitude, stimulation pulse width, or stimulation frequency;monitoring an evoked action potential while the stimulation parameter is being increased;determining, based on the monitoring, whether a threshold of the evoked action potential has been reached; andin response to a determination that the threshold of the evoked action potential has been reached, recording a first value of the stimulation parameter that resulted in the threshold of the evoked action potential being reached.22. The method of claim 21 , further comprising: using the first value of the stimulation parameter in a computer assisted programming process.23. The method of claim 22 , wherein the using the first value comprises assigning the first value of the stimulation parameter as a starting value in the computer ...

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Номер записи: 17
10-01-2019 дата публикации

INTEGRATED ELECTROMYOGRAPHIC CLINICIAN PROGRAMMER FOR USE WITH AN IMPLANTABLE NEUROSTIMULATOR

Номер: US20190009098A1
Автор: JIANG GUANGQIANG, Schmid Eric, Schroeder Dennis, Woock John
Принадлежит:

An integrated electromyography (EMG) and signal/stimulation generation clinician programmer may be coupled with an implantable temporary or permanent lead in a patient and at least one EMG sensing electrode minimally invasively positioned on a skin surface or within the patient. Generally, the integrated clinician programmer may comprise a portable housing, a signal/stimulation generator, and EMG signal processor, and a graphical user interface. The housing has an external surface and encloses circuitry at least partially disposed within the housing. The signal/stimulation generator may be disposed within the housing and configured to deliver test stimulation to a nerve tissue of the patient via the implantable lead. The EMG signal processor may be disposed within the housing and configured to record a stimulation-induced EMG motor response for each test stimulation via the at least one EMG sensing electrode. The graphical user interface at least partially comprises the external surface of the housing and has a touch screen display for direct user interaction or for use with a keyboard, mouse, or the like. 1. A clinician programmer coupleable with an implantable temporary or permanent lead , the clinician programmer comprising:a portable housing having an external surface and enclosing circuitry at least partially disposed within the housing;a lead connector disposed on the housing for electrical connection with the implantable lead;a foramen needle stimulation connector disposed on the housing for electrical connection to a foramen needle;a signal generator disposed within the housing and configured to deliver a test stimulation to a nerve tissue of the patient via the implantable lead;a graphical user interface at least partially comprising the external surface of the housing and configured to facilitate positioning and programming of the implantable lead based at least on an observed motor response or an EMG recording of an EMG motor response for each test ...

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Номер записи: 18
09-01-2020 дата публикации

METHODS OF BYPASSING NEUROLOGICAL DAMAGE THROUGH MOTOR NERVE ROOT STIMULATION

Номер: US20200009385A1
Автор: Shah Jawad A.
Принадлежит:

A method of stimulating muscle in a person having neurological damage, by applying electric current to nerves at an area above an area of neurological damage, bypassing or bridging an area of neurological damage, and moving the muscle in a natural manner. A method of moving muscles of a paraplegic or a person who suffers from other movement-related disorders of the body by applying electric current to nerves at an area above an area of neurological damage, bypassing or bridging an area of neurological damage, and moving normally non-functioning muscles and moving normally non-functioning limbs. 1. A method of stimulating muscle in a person having neurological damage , including the steps of:applying electric current to nerves at an area above an area of neurological damage;bypassing or bridging an area of neurological damage; andmoving the muscle in a natural manner.2. The method of claim 1 , wherein the nerves are chosen from the group consisting of central nerves claim 1 , nerve roots claim 1 , peripheral nerves claim 1 , individual axons claim 1 , and combinations of axons.3. The method of claim 1 , wherein said applying step is further defined as applying electric current to a nerve bundle and stimulating a muscle group.4. The method of claim 1 , wherein said applying step further includes the step of inserting a motor device including at least one electrode for generating electric current operatively attached to an electrode array and exposed on an inner surface of an array body claim 1 , and a programming mechanism in electrical connection with the at least one electrode for programming operation of the at least one electrode in a person in proximity to the nerves.5. The method of claim 4 , wherein said inserting step further includes a step chosen from the group consisting of wrapping the electrode array around a nerve root claim 4 , placing the electrode array parallel to a nerve root claim 4 , and placing the electrode array in epidural space.6. The method ...

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Номер записи: 19
19-01-2017 дата публикации

METHOD FOR TREATING PREMATURE EJACULATION AND METHOD FOR CONTROLLING PREMATURE EJACULATION TREATMENT DEVICE

Номер: US20170014632A1
Автор: KIMURA Yasuharu
Принадлежит: Astellas Pharma Inc.

Methods of treating premature ejaculation include arranging one or more electrodes to face dorsal penile nerves (DPNs) of a patient with premature ejaculation, and applying an electro stimulation having a frequency and a current by which seminal fluid expulsion is not induced in the patient by the one or more electrodes during a time period from before the start of sexual intercourse to ejaculation. The electro stimulation reversibly extends an intravaginal ejaculatory latency time (IELT) of the patient. Methods of controlling a premature ejaculation treatment device are also provided. 1. A method of treating premature ejaculation , comprising:arranging one or more electrodes to face dorsal penile nerves (DPNs) of a patient with premature ejaculation; andapplying an electro stimulation having a frequency and a current by which seminal fluid expulsion is not induced in the patient by the one or more electrodes during a time period from before the start of sexual intercourse to ejaculation;wherein the electro stimulation reversibly extends an intravaginal ejaculatory latency time (IELT) of the patient.2. The method according to claim 1 , wherein the frequency of the electro stimulation is 100-5 claim 1 ,000 Hz.3. The method according to claim 1 , wherein arranging one or more electrodes comprises implanting one or more electrodes surgically under skin at a proximal portion of the penis of the patient in contact with DPNs.4. The method according to claim 1 , wherein arranging one or more electrodes comprises arranging one or more electrodes to face less than all DPNs of the patient.5. The method according to claim 1 , wherein applying the electro stimulation comprises applying the electro stimulation for a period of time that does not exceed 60 minutes per day.6. A method of controlling a premature ejaculation treatment device for extending IELT of a patient with premature ejaculation claim 1 , the device comprising:an intracorporeal device comprising one or more ...

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Номер записи: 20
18-01-2018 дата публикации

SYSTEM AND METHOD FOR MINIMALLY INVASIVE LEAD IMPLANTATION FOR CAVERNOSAL NERVE STIMULATION CONTROLLED AND POWERED WIRELESSLY FROM AN EXTERNAL SOURCE

Номер: US20180015288A1
Автор: Peters Kenneth M., SIRLS LARRY T.
Принадлежит:

Provided is a system and method for cavernosal neuromodulation as directed by a wireless remote controller and power supply. The system including: an implantable lead having at least one electrode structured and arranged to be disposed proximate to the cavernous nerve in a penis; a portable power supply; and a controller having wireless communication electronics and control circuitry associated with the wireless communication electronics structured and arranged to wirelessly couple the power supply to the at least one electrode, the controller further structured and arranged to permit a user to select at least one instruction set for the at least electrode. The controller and power supply may be provided by a control ring. An associated method of use is also provided. 1. A system for cavernosal neuromodulation controlled and powered wirelessly from an external source , comprising:an implantable lead having at least one electrode structured and arranged to be disposed proximate to the cavernous nerve in a penis;a portable power supply; anda controller having wireless communication electronics and control circuitry associated with the wireless communication electronics structured and arranged to wirelessly couple the power supply to the at least one electrode, the controller further structured and arranged to permit a user to select at least one instruction set for the at least electrode.2. The system of claim 1 , wherein the portable power supply and controller are integrated in a removable control ring structured and arranged to be disposed about the penis claim 1 , power provided to the electrode by electrical radiative coupling.3. The system of claim 2 , wherein the removable control ring is adjustable.4. The system of claim 2 , wherein the removable control ring provides a constriction force to the penis.5. The system of claim 2 , wherein the control ring is formed of medical grade silicon or other appropriate material.6. The system of claim 1 , wherein the at ...

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Номер записи: 21
21-01-2021 дата публикации

ANATOMICAL TARGETING OF NEUROMODULATION

Номер: US20210016090A1
Автор: Hershey Bradley Lawrence, Moffitt Michael A., Zhang Tianhe
Принадлежит:

A neuromodulation targeting system includes a GUI that facilitates selection of one or more neuromodulation target regions. The GUI provides an interactive display representing anatomy of a patient with user-selectable portions corresponding to a plurality of predefined anatomical regions associated with distinct localized clinical effects of neuromodulation. The system further includes a targeting selector engine that is responsive to user selection of a first portion of the interactive display by configuring delivery of neuromodulation therapy to a first target region to produce a first localized clinical effect in the patient at a location corresponding to the first portion of the display, upon administration of the neuromodulation therapy to the patient. 1. A neuromodulation targeting system facilitating spatial selection of a neuromodulation objective for a neuromodulation therapy to be delivered by a neuromodulation device , the system comprising:a graphical user interface (GUI) that includes an interactive display representing anatomy of a patient with user-selectable anatomic sites associated with a plurality of predefined neural pathways corresponding to distinct localized clinical effects of neuromodulation, wherein the interactive display further facilitates selection of an exclusion zone of the anatomy of the patient that is to be free of one or more specified types of neuromodulation; anda targeting selector engine operatively coupled with the GUI, the targeting selector engine being responsive to user selection of a first anatomic site and user selection of the exclusion zone to:computationally determine a first target region where the neuromodulation therapy is to be directed while keeping the user selected exclusion zone free from the one or more specified types of neuromodulation, the first target region being distinct from an anatomic location corresponding to the user-selected first anatomic site, andconfigure delivery of the neuromodulation ...

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Номер записи: 22
24-01-2019 дата публикации

TUNABLE NEURAL ELECTRODE

Номер: US20190022375A1
Автор: Ahmadi Mahdi, Chen Wei, Cruttenden Corey Edward, Rajamani Rajesh, Zhu Xiao-Hong
Принадлежит:

A device includes a substrate, an electrode, an electrical pad, and a signal line. The signal line is coupled to the substrate and covered by an insulation layer. The signal line is coupled to the electrical pad and the electrode. At least one of the electrode and the signal line includes a diamagnetic material and paramagnetic material, wherein a ratio of the diamagnetic material and the paramagnetic material is selected based on the susceptibility properties of a physiological tissue. The term paramagnetic herein refers to magnetic susceptibility greater than that of the surrounding tissue and diamagnetic refers to magnetic susceptibility lower than that of the tissue. 1. A device comprising:a substrate having a surface;a signal line coupled to the substrate and covered by an insulation layer;an electrical pad coupled to the signal line; andan electrode coupled to the signal line;wherein at least one of the electrode or the signal line includes a diamagnetic material and a paramagnetic material, wherein diamagnetic and paramagnetic are relative to a physiological tissue, wherein a ratio of the diamagnetic material and the paramagnetic material is selected based on the physiological susceptibility property of the tissue.2. The device of claim 1 , wherein the physiological tissue is a neural or spinal tissue.3. The device of claim 1 , wherein the physiological tissue is a or muscular tissue.4. The device of claim 1 , where the electrode is a recording electrode or stimulating electrode.5. A fabrication method comprising:providing a substrate;forming a signal line on the substrate;forming an electrode, such that the electrode is coupled to the signal line, wherein at least one of the electrode or signal line includes diamagnetic material and paramagnetic material relative to a physiological tissue in a ratio determined by the properties of the physiological tissue; andselectively applying insulation to the signal lines.6. The method of claim 5 , wherein the ratio is ...

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Номер записи: 23
28-01-2021 дата публикации

DEVICE AND METHOD FOR NEUROMODULATION

Номер: US20210023379A1
Автор: Possover Marc
Принадлежит:

The present invention relates to a preoperative test method, to an implantation system () and to an implantation method for implanting a neuroprosthesis in the area of the pubic bone (), wherein implantation is ultimately simplified and made more effective directly or indirectly by the subject-matters of the invention. 1211912. A preoperative test method for implanting a neuroprosthesis comprising a pacemaker () and an electrode array for the most direct stimulation possible of nerves () in the genital area () , the method comprising:{'b': '30', 'placing removable, electrodes () on the body surface of a genital area of the patient;'}inducing in the patient a physical condition exhibiting symptoms to be treated with the neuroprosthesis;{'b': '30', 'energizing the electrodes () with a test current'}{'b': '30', 'recording change caused in the symptoms by energization of the electrodes ()'}230. The method according to claim 1 , wherein the electrodes () are adhesive electrodes.330. The method according to claim 1 , wherein the electrodes () are energized with a test current with current pulses of 150 μs to 250 μs in length claim 1 , preferably with a frequency of 10 Hz to 50 Hz claim 1 , especially preferably with an amplitude of 5 mA to 60 mA.4. The method according to claim 3 , wherein the electrodes are energized with a frequency of 10 Hz to 50 Hz.5. The method according to claim 3 , wherein the electrodes are energized with an amplitude of 5 mA to 50 mA.6301302. The method according to claim 1 , wherein a first electrode (.) is placed in the area of the clitoris or of the root of the penis and a second electrode (.) is placed laterally offset at the same height claim 1 , preferably at a distance of 2 to 3 cm from an outer labium or at a lateral offset of 2 to 3 cm from the root of the penis.73023030. The method according to claim 6 , wherein laterally offset placement of the second electrode (.) is performed successively on both sides of the body claim 6 , and upon ...

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Номер записи: 24
04-02-2016 дата публикации

HIGH DENSITY EPIDURAL STIMULATION FOR FACILITATION OF LOCOMOTION, POSTURE, VOLUNTARY MOVEMENT, AND RECOVERY OF AUTONOMIC, SEXUAL, VASOMOTOR, AND COGNITIVE FUNCTION AFTER NEUROLOGICAL INJURY

Номер: US20160030748A1
Автор: Angeli Claudia A., Burdick Joel W., Desautels Thomas Anthony, EDGERTON Victor Reggie, GERASIMENKO Yury, Harkema Susan J., Hodes Jonathan, Nandra Mandheerej S., ROY Roland R., Tai Yu-Chong
Принадлежит:

Methods of enabling locomotor control, postural control, voluntary control of body movements (e.g., in non-weight bearing conditions), and/or autonomic functions in a human subject having spinal cord injury, brain injury, or neurological neuromotor disease are described. 1. A method comprising:applying an electrical stimulation to a portion of a spinal cord of a neurologically paralyzed patient in conjunction with physical training of a paralyzed portion of the neurologically paralyzed patient,wherein the electrical stimulation is below an amount that fully activates a spinal circuit such that the spinal circuit is at least partially activatable by the addition of supraspinal signals.2. The method of claim 1 , wherein the paralysis is a motor complete paralysis or a motor incomplete paralysis.3. The method of claim 1 , wherein the electrical stimulation does not directly activate muscle cells in the paralyzed portion of the patient's body.4. The method of claim 1 , wherein the physical training provides induced neurological signals claim 1 , and the induced neurological signals comprise at least one of postural proprioceptive signals claim 1 , locomotor proprioceptive signals claim 1 , and the supraspinal signals.5. The method of claim 1 , wherein the neurologically paralyzed patient has a spinal cord injury classified as motor complete or motor incomplete.6. The method of claim 1 , wherein the neurologically paralyzed patient had an ischemic brian injury claim 1 , a traumatic brain injury claim 1 , or a neurodegenerative brain injury.7. The method of claim 6 , wherein the neurodegenerative brain injury is associated with at least one of Parkinson's disease claim 6 , Huntington's disease claim 6 , Alzheimer's claim 6 , ischemia claim 6 , stroke claim 6 , amyotrophic lateral sclerosis (ALS) claim 6 , primary lateral sclerosis (PLS) claim 6 , and cerebral palsy.8. The method of claim 1 , wherein the applying the electrical stimulation is by an electrode array that is ...

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Номер записи: 25
01-02-2018 дата публикации

Systems and methods for making and using an electrical stimulation system for peripheral nerve stimulation

Номер: US20180028804A1
Автор: Anne Margaret Pianca
Принадлежит: Boston Scientific Neuromodulation Corp

An electrical stimulation lead includes a lead body; a terminal disposed along the proximal end portion of the lead body; a single electrode disposed at the distal end of the lead body; a conductor extending along the lead body and electrically coupling the terminal to the single electrode; and an adjustable sheath disposed over a portion of the lead body to cover a selected portion of the single electrode by displacing the sheath forwards or backwards relative to the single electrode to control a size of a portion of the electrode exposed for stimulation of tissue. Another electrical stimulation lead has a low-profile distal portion that has a smaller lateral width in at least one direction than a remainder of the lead body. Yet another arrangement includes a guidewire with a mapping electrode to map a region around a peripheral nerve prior to implantation of an electrical stimulation lead.

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Номер записи: 26
05-02-2015 дата публикации

Functional Electrical Stimulation Device and System, and Use Thereof

Номер: US20150039051A1
Автор: Aleksandar Prodic, Massimo Tarulli, Milos R. Popovic, Peter Lehn
Принадлежит: UNIVERSITY HEALTH NETWORK

A functional electrical stimulation (FES) device and system. In one embodiment, sequential bipolar pulse stimulation may be provided to an area of a living body via one or more electrode leads applied to the area via a FES device comprising a current pulse generating circuit comprising output nodes for operative coupling to the one or more electrode leads, and configured for operative coupling to a voltage supply. The current pulse generating circuit generally comprises positive and negative stimulation paths drawing from the voltage supply to respectively apply positive and negative currents through the area via the one or more electrode leads. In one example, the stimulation paths comprise respective capacitive elements, a capacitance ratio of which dictating, at least in part, an amplitude ratio of the positive and negative currents, wherein periodic alternative activation of the stimulation paths provides the sequential bipolar pulse stimulation.

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Номер записи: 27
24-02-2022 дата публикации

DEVICES AND METHODS FOR REPAIRING DAMAGE TO A TISSUE

Номер: US20220054824A1
Автор: Clements Isaac Perry, Isaacs Jonathan, Ross James David, Weidenbach Alex, Willsie Andrew
Принадлежит:

An example device for repairing a tissue is described herein. The device can include a flexible carrier layer, and a support member including a plurality of micro-protrusions extending therefrom. The support member can be at least partially integrated with the flexible carrier layer. Additionally, the flexible carrier layer can be configured to cover at least a portion of the tissue, and the micro-protrusions can be configured to mechanically interface with the tissue. 1a flexible carrier layer; anda support member comprising a plurality of elongate strips and a plurality of micro-protrusions, the micro-protrusions extending from the elongate strips, wherein:the support member is at least partially integrated with the flexible carrier layer,the flexible carrier layer is configured to cover at least a portion of a tissue,the micro-protrusions are configured to mechanically interface with the tissue,the elongate strips are not interconnected with one another within the flexible carrier layer, andwherein, for each of the elongate strips, a respective length extending along a longitudinal axis of the tissue is longer than a respective length extending along an axis perpendicular to the longitudinal axis of the tissue.. A device, comprising: This application is a continuation of U.S. patent application Ser. No. 17/306,049, filed on May 3, 2021, which is a continuation of U.S. patent application Ser. No. 15/697,358, filed on Sep. 6, 2017 (now U.S. Pat. No. 10,994,130), which claims the benefit of U.S. Provisional Patent Application No. 62/383,934, filed on Sep. 6, 2016, entitled “DEVICES AND METHODS FOR REPAIRING DAMAGE TO A NERVE,” the disclosures of which are expressly incorporated herein by reference in their entireties.Over a quarter of a million nerve injuries are reported annually in the United States alone. The majority of these injuries require surgical treatment, yet fewer than half recover to satisfactory levels. Nerve injuries affect up to 5% of all trauma ...

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Номер записи: 28
07-02-2019 дата публикации

METHOD AND SYSTEM FOR MODULATING NEURAL ACTIVITY

Номер: US20190038831A1
Автор: Dacey, Della Rocca Gregory J., Derdeyn Colin P., Dowling Joshua L., Goodall Eleanor V., Hyde Roderick A., Ishikawa Muriel Y., JR. Lowell L., JR. Ralph G., Kare Jordin T., Leuthardt Eric C., Myhrvold Nathan P., Smith Michael A., Wood, Wood Victoria Y.H., Zipfel Gregory J.
Принадлежит:

Methods and related systems for modulating neural activity by modulating neural activity in a nerve plexus of a subject are disclosed. Neural activity may be modulated by stimuli delivered via various types of stimulus sources. Neural modulation may be used, for example, to modulate an undesired sensation, such as pain. Delivery of stimuli for modulating neural activity may be controlled in part in based on an activity state of the subject. 127.-. (canceled)28. A neural modulation method , comprising:receiving an activity signal indicative of an activity state of a subject;determining an activity state of the subject based on the activity signal;delivering a nerve blocking stimulus to a nerve plexus of the subject responsive to the determined activity state of the subject, wherein the nerve blocking stimulus is adapted to modulate pain in the subject; anddetermining that a desired pain modulation effect has been produced.29. The method of claim 28 , including determining that the desired pain modulation effect has been produced by sensing a physiological parameter from the subject.30. The method of claim 28 , including determining that the desired pain modulation effect has been produced by sensing a physical parameter from the subject.31. The method of claim 28 , including determining that the desired pain modulation effect has been produced by obtaining qualitative or subjective reporting from the subject.32. The method of claim 28 , wherein the activity signal includes a signal indicative of a physiological activity.33. The method of claim 32 , wherein the physiological activity includes at least one of heart rate claim 32 , respiration claim 32 , brain activity claim 32 , peripheral neural activity claim 32 , muscle activity claim 32 , or body temperature of the subject.34. The method of claim 32 , wherein the activity signal includes an electroencephalographic signal claim 32 , an electromyographic signal claim 32 , an electrocardiographic signal claim 32 , an ...

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Номер записи: 29
18-02-2016 дата публикации

DEVICES AND SYSTEMS FOR TREATING OBSTETRIC AND GYNECOLOGICAL DISORDERS

Номер: US20160045728A1
Автор: Funai Edmund, Lockwood Charles, Rezai Ali R.
Принадлежит:

One aspect of the present disclosure relates to a therapy delivery device for treating an obstetric or gynecological disorder other than urinary incontinence in a subject. The therapy delivery device can include a housing, at least one electrode, and a power source. The housing can be configured for implantation in a reproductive system of the subject. The at least one electrode can be connected to the housing and be configured to delivery an electrical signal to an autonomic nervous system nerve target. The power source can be in electrical communication with the at least one electrode. 125-. (canceled)26. A therapy delivery system for treating an obstetric or gynecological disorder other than urinary incontinence in a subject , the therapy delivery system comprising:a housing configured for implantation in a reproductive system of the subject;at least one electrode connected to the housing and configured to deliver an electrical signal to an autonomic nervous system (ANS) nerve target; anda controller programmed to direct delivery of the electrical signal to the at least one electrode to modulate activity at the ANS nerve target site to treat the obstetric or gynecological disorder.27. The therapy delivery system of claim 26 , wherein the housing is configured for implantation in a uterus claim 26 , a vagina claim 26 , an ovary claim 26 , a fallopian tube claim 26 , or a cervix of the subject.28. The therapy delivery system of claim 26 , wherein the controller is programmed to delivery an electrical signal having a frequency of about 1000 Hz or greater.29. The therapy delivery system of claim 26 , wherein the ANS nerve target is a parasympathetic nerve.30. The therapy delivery system of claim 29 , wherein the parasympathetic nerve is a pelvic splanchnic nerve.31. The therapy delivery system of claim 26 , wherein the ANS nerve target is sympathetic nerve.32. The therapy delivery system of claim 31 , wherein the sympathetic nerve is a hypogastric nerve claim 31 , a ...

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Номер записи: 30
15-02-2018 дата публикации

Implantable Electroacupuncture Device and Method for Treating Erectile Dysfunction

Номер: US20180042758A1
Автор: Greiner Jeffrey H., Greiner Stacy O., Peterson David K. L., Thenuwara Chuladatta
Принадлежит:

An exemplary method treating an erectile dysfunction condition in a patient includes 1) generating, by an electroacupuncture device implanted beneath a skin surface of the patient, stimulation sessions at a duty cycle that is less than 0.05, and 2) applying, by the electroacupuncture device in accordance with the duty cycle, the stimulation sessions to a target tissue location within the patient by way of an electrode array located within the patient at an acupoint corresponding to the target tissue location. 1. A method of treating an erectile dysfunction condition in a patient , comprising: each stimulation session included in the stimulation sessions comprises a series of stimulation pulses,', {'b': 3', '4, 'the duty cycle is a ratio of T to T,'}, {'b': 3', '4, 'each stimulation session included in the stimulation sessions has a duration of T minutes and occurs at a rate of once every T minutes, and'}, 'the electroacupuncture device is powered by a primary battery located within the electroacupuncture device and having an internal impedance greater than 5 ohms; and, 'generating, by an electroacupuncture device implanted beneath a skin surface of the patient, stimulation sessions at a duty cycle that is less than 0.05, wherein'}applying, by the electroacupuncture device in accordance with the duty cycle, the stimulation sessions to a target tissue location within the patient by way of an electrode array located within the patient at an acupoint corresponding to the target tissue location.2. The method of claim 1 , wherein the primary battery located within the electroacupuncture device has a capacity of less than 60 milliamp-hours (mAh).3. The method of claim 1 , wherein:a housing of the electroacupuncture device is coin-sized and coin-shaped; andthe primary battery located within the electroacupuncture device is a coin-cell battery.4. The method of claim 1 , wherein the primary battery located within the electroacupuncture device is not rechargeable.5. The method ...

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Номер записи: 31
16-02-2017 дата публикации

SYSTEM AND METHOD FOR IMPLANTATION OF LEAD AND ELECTRODES TO THE ENDOPELVIC PORTION OF THE PELVIC NERVES AND CONNECTION CABLE FOR ELECTRODE WITH DIRECTION MARKER

Номер: US20170043156A1
Автор: Possover Marc
Принадлежит:

A collector electrode assembly which can be implanted by laparoscopy through the abdominal wall into the small pelvis of the human body includes a collector electrode for neurostimulation of nerves; a connection cable having an outer surface, said collector electrode being arranged at one end of said connection cable and comprising several outer segment electrodes which can be contacted individually and/or in groups and which are arranged axially one after another in the direction of the longitudinal extent of the collector electrode, wherein an insulating section is arranged axially between in each case two adjacent outer segment electrodes and permits electrical insulation of respective two adjacent outer segment electrodes; radially expandable fixing structures positioned on the collector electrode and radially expandable from a withdrawn position to a radially expanded position for fixing the collector electrode in place at said nerves; a visually perceptible direction marker on the outer surface of the connection cable, at least in a cable section which is spaced apart from axial ends of the connection cable and has an axial extent of at least 10 cm and/or at least 15% of total length of the connection cable, said direction marker indicating orientation of the connection cable to an operator using the assembly, and wherein the direction marker is designed and arranged in such a way that the identification of the orientation of the connection cable is possible at any desired axial section of the cable section having a maximum axial extent of 2 cm. 1. A collector electrode assembly which can be implanted by laparoscopy through the abdominal wall into the small pelvis of the human body , comprising:a collector electrode for neurostimulation of nerves;a connection cable having an outer surface, said collector electrode being arranged at one end of said connection cable and comprising several outer segment electrodes which can be contacted individually and/or in ...

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Номер записи: 32
16-02-2017 дата публикации

Biomimetic multichannel neurostimulation

Номер: US20170043166A1
Автор: John S. CHOI, Joseph T. FRANCIS
Принадлежит: Research Foundation of State University of New York

Sensory information can be delivered to a subject mammal, for example, for restoring a sense of cutaneous touch and limb motion to the subject mammal. A biomimetic electrical signal is generated based on (a) a stimulation reference signal applied to a somatosensory region of a nervous system of a reference mammal, (b) a stimulated-response signal acquired from a sensory cortex of the reference mammal in response to application of the stimulation reference signal to the thalamic nucleus, and (c) a natural-response signal acquired from the sensory cortex in response to peripheral touch stimuli and/or peripheral nerve stimulation of the reference mammal. The biomimetic electrical signal is applied to a somatosensory region of a nervous system of the subject mammal to induce an activation response, in a sensory cortex of the subject mammal.

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Номер записи: 33
16-02-2017 дата публикации

Controlling Charge Flow in the Electrical Stimulation of Tissue

Номер: US20170043169A1
Автор: Jordi Parramon, Kelly H. Mcclure, Rafael Carbunaru
Принадлежит: Boston Scientific Neuromodulation Corp

Systems of techniques for controlling charge flow during the electrical stimulation of tissue. In one aspect, a method includes receiving a charge setting describing an amount of charge that is to flow during a stimulation pulse that electrically stimulates a tissue, and generating and delivering the stimulation pulse in a manner such that an amount of charge delivered to the tissue during the stimulation pulse accords with the charge setting.

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Номер записи: 34
15-02-2018 дата публикации

SYSTEMS AND METHODS FOR TREATING SEXUAL DISORDERS USING ELECTRO-STIMULATION

Номер: US20180043164A1
Автор: FRAGA DA SILVA Rodrigo Araujo, STERGIOPULOS Nikolaos
Принадлежит: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)

Systems and methods are provided for treating a sexual disorder such as erectile dysfunction (ED) or female sexual arousal disorder (FSAD). An electrical stimulation system may include an implantable stimulation unit, an external patient controller, and an external physician controller. The implantable stimulation unit has an array of electrodes disposed on one or more flexible substrates configured to conform to a patient's anatomy at the pelvic plexus. Post-implantation, the physician controller may direct the stimulation unit to stimulate with select electrode(s) of the array to determine which electrode configuration provides optimal sexual arousal. The patient controller may be used to cause the stimulation unit to stimulate using the optimal electrode configuration at desired times. 1. A method of treating a sexual disorder , the method comprising:placing an array of electrodes adjacent a prostate or where a native prostate was located prior to prostatectomy; andsupplying electrical stimulation via at least one electrode of the array of electrodes to stimulate a pelvic plexus and thereby at least one cavernous nerve to cause an erection.2. The method of claim 1 , wherein the array of electrodes is disposed on at least one flat flexible substrate sized and shaped to abut at least a portion of the pelvic plexus and configured to bend to conform to an anatomical shape of the portion of the pelvic plexus.3. The method of claim 2 , wherein electrodes of the array of electrodes comprise a plurality of rows and a plurality of columns disposed on the at least one flat flexible substrate and each electrode is individually selectable.4. The method of claim 2 , wherein the at one least flat flexible substrate comprises a first flat flexible substrate configured to conform to a first half of the pelvic plexus and a second flat flexible substrate configured to conform to a second half of the pelvic plexus.5. The method of claim 4 , wherein a first portion of the array of ...

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Номер записи: 35
21-02-2019 дата публикации

METHOD AND SYSTEM FOR PROVIDING ELECTRICAL STIMULATION TO A USER

Номер: US20190054298A1
Автор: Chao Daniel S., Sanchez Sophia, Sarva Amol, Von Kraus Lee, Wingeier Brett
Принадлежит:

A method for providing electrical stimulation to a user as a user performs a set of tasks during a time window, the method comprising: providing an electrical stimulation treatment, characterized by a stimulation parameter and a set of portions, to a brain region of the user in association with the time window; for each task of the set of tasks: receiving a signal stream characterizing a neurological state of the user; from the signal stream, identifying a neurological signature characterizing the neurological state associated with the task; and modulating the electrical stimulation treatment provided to the brain region of the user based upon the neurological signature, wherein modulating comprises delivering a portion of the set of portions of the electrical stimulation treatment to the brain region of the user, while maintaining an aggregate amount of the stimulation parameter of the treatment provided during the time window below a maximum limit. 1providing an electrical stimulation device at a head region of the user; and delivering a first portion of the set of portions of the electrical stimulation session to the brain region of the user in association with a first event of the set of events,', 'delivering a second portion of the set of portions of the electrical stimulation session to the brain region of the user in association with a second event of the set of events, and', 'providing at least one resting period between the first portion and the second portion of the electrical stimulation session, while maintaining an aggregate amount of the stimulation parameter of the electrical stimulation session provided to the user during the time window below a maximum limit., 'with the electrical stimulation device, providing an electrical stimulation session, characterized by a stimulation parameter and a set of portions, to a brain region of the user in association with the time window, wherein providing the electrical stimulation session comprises. A method for ...

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Номер записи: 36
21-02-2019 дата публикации

System, Method, and Device for Providing Feedback to a Patient During Electrical Stimulation

Номер: US20190054301A1
Автор: Iyassu Yohannes, Kaula Norbert
Принадлежит:

Feedback regarding electrical stimulation is provided to a patient. Electrical stimulation is applied to the patient. The electrical stimulation is applied by varying an electrical stimulation parameter. A signal is communicated to the patient via an electronic device. The signal is correlated with the electrical stimulation parameter such that the signal varies in association with the varying of the electrical stimulation parameter. The communicating is performed while the electrical stimulation is applied. Feedback is received from the patient in response to the electrical stimulation. Based on the received feedback from the patient, the electrical stimulation is adjusted. 1. A method of providing feedback to a patient regarding electrical stimulation , comprising:applying electrical stimulation to the patient, wherein the applying of the electrical stimulation comprises varying an electrical stimulation parameter;communicating, to the patient via an electronic device, a signal that is correlated with the electrical stimulation parameter such that the signal varies in association with the varying of the electrical stimulation parameter, wherein the communicating is performed while the electrical stimulation is applied; andreceiving feedback from the patient in response to the electrical stimulation.2. The method of claim 1 , further comprising: adjusting the electrical stimulation based on the received feedback from the patient.3. The method of claim 1 , wherein the electronic device is a patient feedback tool that is configured to generate the signal and also configured to be physically engaged by the patient claim 1 , and wherein the receiving of the feedback from the patient comprises detecting a physical engagement from the patient via the patient feedback tool.4. The method of claim 1 , wherein:the applying of the electrical stimulation is performed at least in part via a pulse generator; andthe electronic device is an electronic programmer configured to ...

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Номер записи: 37
15-05-2014 дата публикации

CHARGE-ENHANCED NEURAL ELECTRIC STIMULATION SYSTEM

Номер: US20140135858A1
Автор: Ahmed Zaghloul, Wieraszko Andrzej
Принадлежит:

A system and method to treat neural communication impairment is provided. The neural communication impairment is present in a neural pathway, which can be a cortico-neuromuscular pathway, an intra-brain neural pathway, or in a sensory-cortico pathway. A synchronized external stimulation is applied to a first point in proximity to a first neural component at one end of the neural pathway and to a second point in proximity to a second neural component at the other end of the neural pathway. Two induced neural handshake signals contemporaneously arrive at a neural communication impairment point in the neural pathway, triggering and stimulating a rehabilitation process by which the neural connection is permanently improved. The synchronized applied electrical signals applied to the first and second points may have an opposite polarity in dipolar neural stimulation, or may have identical polarity and waveform in in-phase neural stimulation. 157-. (canceled)58. A system for improving neural communication between a cognitive area and a target area of a vertebrate being , said cognitive and target areas coupled by neuronal connections passing through a spinal junction area and defining neural pathway , said system comprising:signal controlling means for controlling timing of delivery from a first signal source of pulsed signals to said cognitive area for inducing at said cognitive area first pulsed neural signals on said neural pathway;a second signal source, said second signal source supplying a second stimulation signal having a second of pulsed signals for inducing at said target area second pulsed neural signals on said neural pathway;a third signal source, said third signal source delivering a continuous charging signal to said junction area during a charging period;said signal controlling means configured to synchronize simultaneous presence of said first pulsed neural signals and said second pulsed neural signals in presence of said charging signal at said junction ...

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Номер записи: 38
05-03-2015 дата публикации

METHODS, SYSTEMS, AND DEVICES FOR PAIRING VAGUS NERVE STIMULATION WITH MOTOR THERAPY IN STROKE PATIENTS

Номер: US20150066099A1
Автор: ENGINEER Navzer, KILGARD Michael P., PIERCE David Michael, RENNAKER Robert L.
Принадлежит:

A method of treating motor deficits in a stroke patient, comprising assessing a patient's motor deficits, determining therapeutic goals for the patient, based on the patient's motor deficits, selecting therapeutic tasks based on the therapeutic goals, performing each of the selected therapeutic tasks repetitively, observing the performance of the therapeutic tasks, initiating the stimulation of the vagus nerve manually at approximately a predetermined moment during the performance of the therapeutic tasks, stimulating the vagus nerve of the patient during the performance of the selected therapeutic tasks, and improving the patient's motor deficits. 1. A method of improving motor deficits in a stroke patient , comprising:selecting one or more therapeutic tasks;observing repetitive performances by the patient of the selected therapeutic task;stimulating a vagus nerve of the patient with an implanted neurostimulator that delivers pulse trains of electrical stimulation energy to the vagus nerve while the patient is performing a movement of the selected therapeutic task;terminating the stimulation of the vagus nerve so that there is no stimulation between movement execution; and improving the patient's motor deficits,wherein the action of stimulating the vagus nerve of the patient further comprises determining respective beginnings of performances of the selected therapeutic task, and applying the pulse trains to the vagus nerve based on the determined beginnings of the performances, and wherein the stimulation pulse trains begin after the beginning of the respective selected therapeutic tasks, wherein the vagus nerve stimulation pulse trains end prior to the end of the respective selected therapeutic tasks, and wherein the vagus nerve stimulation pulse train is not presented between performances of the selected therapeutic task.2. The method of claim 1 , wherein the pulse trains are about 500 milliseconds in duration.3. The method of claim 1 , wherein the pulse trains ...

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Номер записи: 39
05-03-2015 дата публикации

METHODS, SYSTEMS, AND DEVICES FOR PAIRING VAGUS NERVE STIMULATION WITH MOTOR THERAPY IN STROKE PATIENTS

Номер: US20150066100A1
Автор: ENGINEER Navzer, KILGARD Michael P., PIERCE David Michael, RENNAKER Robert L.
Принадлежит:

A method of treating motor deficits in a stroke patient, comprising assessing a patient's motor deficits, determining therapeutic goals for the patient, based on the patient's motor deficits, selecting therapeutic tasks based on the therapeutic goals, performing each of the selected therapeutic tasks repetitively, observing the performance of the therapeutic tasks, initiating the stimulation of the vagus nerve manually at approximately a predetermined moment during the performance of the therapeutic tasks, stimulating the vagus nerve of the patient during the performance of the selected therapeutic tasks, and improving the patient's motor deficits. 1. A method of improving motor deficits in a stroke patient , comprising:selecting a therapeutic task;detecting motion during repetitive performances by the patient of the selected therapeutic task;automatically stimulating a vagus nerve of the patient with an implanted neurostimulator that delivers pulse trains of electrical stimulation energy to the vagus nerve when a predetermined motion is detected;ending the stimulation of the vagus nerve so that there is no stimulation between the performances; and improving the patient's motor deficits,wherein the action of stimulating the vagus nerve of the patient further comprises determining respective beginnings of performances of the selected therapeutic task, and applying the pulse trains to the vagus nerve based on the determined beginnings of the performances, and wherein the stimulation pulse trains begin after the beginning of the respective selected therapeutic tasks, wherein the vagus nerve stimulation pulse trains end prior to the end of the respective selected therapeutic tasks, and wherein the vagus nerve stimulation pulse train is not presented between performances of the selected therapeutic task.2. The method of claim 1 , wherein the pulse trains are about 500 milliseconds in duration.3. The method of claim 1 , wherein the pulse trains have an amplitude of about ...

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Номер записи: 40
05-03-2015 дата публикации

METHODS, SYSTEMS, AND DEVICES FOR PAIRING VAGUS NERVE STIMULATION WITH MOTOR THERAPY IN STROKE PATIENTS

Номер: US20150066101A1
Автор: ENGINEER Navzer, KILGARD Michael P., PIERCE David Michael, RENNAKER Robert L.
Принадлежит:

A method of treating motor deficits in a stroke patient, comprising assessing a patient's motor deficits, determining therapeutic goals for the patient, based on the patient's motor deficits, selecting therapeutic tasks based on the therapeutic goals, performing each of the selected therapeutic tasks repetitively, observing the performance of the therapeutic tasks, initiating the stimulation of the vagus nerve manually at approximately a predetermined moment during the performance of the therapeutic tasks, stimulating the vagus nerve of the patient during the performance of the selected therapeutic tasks, and improving the patient's motor deficits. 1. A method of improving motor deficits in a stroke patient , comprising:stimulating a vagus nerve of the patient by delivering pulse trains of artificial electrical stimulation energy from a stimulation device to the vagus nerve while the patient is performing a movement of a therapeutic task;terminating the stimulation of the vagus nerve so that there is no stimulation between movement execution; andimproving the patient's motor deficits,wherein the action of stimulating the vagus nerve of the patient further comprises determining respective beginnings of performances of the therapeutic task, and applying the pulse trains to the vagus nerve based on the determined beginnings of the performances, and wherein the stimulation pulse trains begin after the beginning of the respective therapeutic tasks, wherein the vagus nerve stimulation pulse trains end prior to the end of the respective therapeutic tasks, and wherein the vagus nerve stimulation pulse train is not presented between performances of the therapeutic task.2. The method of claim 1 , wherein the pulse trains are about 500 milliseconds in duration.3. The method of claim 1 , wherein the pulse trains have an amplitude of about 0.8 milliamperes.4. The method of claim 1 , wherein a therapeutic task level is selected for each therapeutic task and the therapeutic task ...

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Номер записи: 41
05-03-2015 дата публикации

Method and system for providing electrical stimulation to a user

Номер: US20150066104A1
Автор: Amol Sarva, Brett Wingeier, Daniel S. Chao, Lee Von Kraus, Sophia Sanchez
Принадлежит: Halo Neuro Inc

A method for providing electrical stimulation to a user as a user performs a set of tasks during a time window, the method comprising: providing an electrical stimulation treatment, characterized by a stimulation parameter and a set of portions, to a brain region of the user in association with the time window; for each task of the set of tasks: receiving a signal stream characterizing a neurological state of the user; from the signal stream, identifying a neurological signature characterizing the neurological state associated with the task; and modulating the electrical stimulation treatment provided to the brain region of the user based upon the neurological signature, wherein modulating comprises delivering a portion of the set of portions of the electrical stimulation treatment to the brain region of the user, while maintaining an aggregate amount of the stimulation parameter of the treatment provided during the time window below a maximum limit.

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Номер записи: 42
28-02-2019 дата публикации

PATTERNED STIMULATION INTENSITY FOR NEURAL STIMULATION

Номер: US20190060648A1
Автор: Schiefer Matthew, Tan Daniel, Tyler Dustin
Принадлежит:

One aspect of the present disclosure relates to a system that can modulate the intensity of a neural stimulation signal over time. A pulse generator can be configured to generate a stimulation signal for application to neural tissue of an individual and modulate a parameter related to intensity of a pattern of pulses of the stimulation signal over time. An electrode can be coupled to the pulse generator and configured to apply the stimulation signal to the neural tissue. A population of axons in the neural tissue can be recruited with each pulse of the stimulation signal. 1. A method for providing artificial sensation comprising:determining a virtual sensation to be felt by an individual based on a stimulation;configuring a stimulation signal with a pattern of stimulation intensities based on the virtual sensation to be felt by the individual; anddelivering the stimulation signal with the pattern of stimulation intensities to one or more peripheral nerves to cause the individual to experience the virtual sensation.2. The method of claim 1 , further comprising:receiving a feedback signal based on the virtual sensation; andreconfiguring the stimulation signal with a new pattern of stimulation intensities based on the feedback signal.3. The method of claim 1 , wherein the one or more peripheral nerves comprise a median nerve claim 1 , an ulnar nerve claim 1 , and/or a radial nerve.4. The method of claim 1 , wherein individual is an able-bodied individual claim 1 , an amputee claim 1 , a paralyzed individual claim 1 , or a diseased individual.5. The method of claim 1 , wherein the stimulation is related to a touch-enabled virtual reality.6. The method of claim 5 , wherein the touch-enabled virtual reality is related to a user interface claim 5 , a clinical diagnosis claim 5 , a mechanical diagnosis claim 5 , a robotic control claim 5 , and/or a telepresence.7. A system comprising: receive a signal comprising information related to a virtual sensation to be felt by an ...

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Номер записи: 43
17-03-2022 дата публикации

NEUROSTIMULATION LEADS FOR TRIAL NERVE STIMULATION AND METHODS OF USE

Номер: US20220080212A1
Автор: Dave Trishna, Lee Henry, Marvicsin David
Принадлежит:

Devices and methods for providing neurostimulation to a patient, particularly in trial systems assessing suitability of a permanently implanted neurostimulation, are provided herein. In one aspect, a trial neurostimulation lead includes a coiled conductor coupled to a proximal contact connector having a retention flange that withstands tensile force from tension in the lead so as to maintain the electrical connection during a trial period. In another aspect, a trial neurostimulation system includes a lead extension that includes a regression stopper between the implanted distal connector and proximal lead disposed outside the body to prevent regression of the lead through a secondary incision, thereby preventing infection and facilitating explant of the system. Methods of assembling and utilizing such leads and systems are detailed herein. 1. A trial neurostimulation system to perform a percutaneous nerve evaluation for sacral nerve stimulation therapy , the system comprising:a temporary evaluation lead for a nerve evaluation, the evaluation lead comprising:a single distal electrode,a proximal connector comprising a single proximal contact, anda single conductor electrically connecting the single distal electrode to the single proximal contact,wherein the single conductor is a multi-stranded wire,wherein the single conductor is coiled along a length of the evaluation lead and includes at least a portion having an open coil design between the distal electrode and the proximal contact,wherein the open coil design comprising gaps between adjacent coils so as to provide resistance to migration or regression of the lead; and a lead connector through which the external pulse generator delivers stimulation pulses to the evaluation lead electrically coupled thereto;', 'a pulse generator and associated circuitry that effect control of stimulation generated by the external pulse generator;', 'a battery power source for powering the external pulse generator during an ...

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Номер записи: 44
27-02-2020 дата публикации

SYSTEM AND METHOD FOR BRAIN STIMULATION FOR IMPROVEMENT OF MOTOR SYMPTOMS IN PARKINSON'S DISEASE AND OTHER MOVEMENT DISORDERS

Номер: US20200061382A1
Автор: Mari Zoltan, Salimpour Yousef, Shadmehr Reza
Принадлежит:

An embodiment in accordance with the present invention is directed to a system and device for applying electrical direct current transcranially to the brain that is combined with a behavioral activity consisting of an isometric force production task. The device is non-invasive or implantable and serves to improve motor symptoms in Parkinson's disease (PD) and other movement disorders. During the stimulation, the patient is engaged in a behavioral task using a system consisting of two force transducers and a controller. The patient holds the transducers, one in each hand, and is engaged in a task that requires the brain to assign forces to each arm so that the sum of the forces matches an instructed amount. In an electrode placement specifically for PD, bilateral primary motor cortices are simultaneously stimulated according to a specific algorithm that depends on the forces that the PD affected individual produces in the behavioral task. 1. A system for treatment of Parkinson's disease in a subject comprising:a controller;a force transducer component configured to accept force from a left hand of the subject and a right hand of the subject, wherein the force transducer component is configured to transmit data related to the accepted force to the controller, and wherein the force transducer component is configured to receive instructions from the controller regarding a predetermined force value that the subject is asked to create;a controller that uses the measured forces to compute a laterality index; anda transcranial direct current stimulation component configured to apply transcranial direct stimulation to motor cortices of the subject according to the laterality index, wherein for a subject with a negative laterality index, anodal stimulation is applied to the right motor cortex, and cathodal stimulation is applied to the left motor cortex, and for a subject with a positive laterality index, anodal stimulation is applied over the left motor cortex, and cathodal ...

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Номер записи: 45
08-03-2018 дата публикации

DEVICES AND METHODS FOR REPAIRING DAMAGE TO A NERVE

Номер: US20180064931A1
Автор: Clements Isaac Perry, Isaacs Jonathan, Ross James David, Weidenbach Alex, Willsie Andrew
Принадлежит:

An example device for repairing a nerve is described herein. The device can include a flexible carrier layer made of a biologic material, and a metallic support member including a plurality of micro-protrusions extending therefrom. The metallic support member can be at least partially integrated with the flexible carrier layer. Additionally, the flexible carrier layer can be configured to cover at least a portion of the nerve, and the micro-protrusions can be configured to attach to a superficial tissue of the nerve. 1. A device for repairing a nerve , comprising:a flexible carrier layer, wherein the flexible carrier layer is a biologic material; anda metallic support member comprising a plurality of micro-protrusions extending therefrom, wherein:the metallic support member is at least partially integrated with the flexible carrier layer,the flexible carrier layer is configured to cover at least a portion of the nerve, andthe micro-protrusions are configured to attach to a superficial tissue of the nerve.2. The device of claim 1 , wherein the micro-protrusions are sized and shaped to pierce the outer epineurium of the nerve.3. The device of claim 2 , wherein the micro-protrusions are sized and shaped to not pierce a fascicle of the nerve.4. The device of claim 1 , wherein the metallic support member is a superelastic alloy.5. The device of claim 4 , wherein the superelastic alloy is of a composition that comprises nickel and titanium.6. The device of claim 1 , wherein the biologic material is small intestine submucosa (SIS).7. The device of claim 1 , wherein the flexible carrier layer is a two-dimensional sheet.8. The device of claim 7 , wherein the flexible carrier layer is further configured to entubulate a repair site or sandwich a repair site.9. (canceled)10. (canceled)11. (canceled)12. The device of claim 8 , wherein the flexible carrier layer comprises a wrapping portion for maintaining entubulation or sandwiching of the repair site.13. The device of claim 8 , ...

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Номер записи: 46
08-03-2018 дата публикации

SYSTEM FOR STIMULATING BONE GROWTH, TISSUE HEALING AND/OR PAIN CONTROL, AND METHOD OF USE

Номер: US20180064932A1
Автор: LEUTHARDT Eric Claude, MacEwan Matthew R., Moran Daniel W.
Принадлежит:

A system to deliver current to an area of interest of a subject is described that includes a power source, a controller electrically coupled to the power source, at least one first electrode electrically coupled to the controller, and at least one second electrode electrically coupled to one of the power source and the controller, with the area of interest positioned between the at least one first electrode and the at least one second electrode. A method of stimulating at least one of bone growth, tissue healing and pain control within an area of interest of a patient is described that includes inserting first and second electrode spaced at a predetermined distance, and further includes directing an electric current between the first and second electrodes so that at least a portion of the electric current passes through the area of interest positioned between the first electrode and the second electrode. 1. A system to deliver a current to an area of interest of a subject , the system comprising:a power source;a controller electrically coupled to the power source;at least one first electrode electrically coupled to the controller; andat least one second electrode electrically coupled to one of the power source and the controller, the area of interest positioned between the at least one first electrode and the at least one second electrode;wherein the controller is configured to selectively deliver a current flow from the power source to the at least one first electrode such that at least a portion of the current flow is directed through the area of interest.2. The system of claim 1 , wherein each of the at least one first electrodes and each of the at least one second electrodes is independently selected from the group consisting of: an orthopedic screw claim 1 , an orthopedic rod claim 1 , an orthopedic pin claim 1 , an orthopedic plate claim 1 , a hip stem claim 1 , a femoral stem claim 1 , a dental post claim 1 , a mandibular implant claim 1 , a dental screw.3. ...

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Номер записи: 47
11-03-2021 дата публикации

Patterned stimulation intensity for neural stimulation

Номер: US20210069497A1
Автор: Daniel Tan, Dustin J. Tyler, Matthew SCHIEFER
Принадлежит: CASE WESTERN RESERVE UNIVERSITY

One aspect of the present disclosure relates to a system that can modulate the intensity of a neural stimulation signal over time. A pulse generator can be configured to generate a stimulation signal for application to neural tissue of an individual and modulate a parameter related to intensity of a pattern of pulses of the stimulation signal over time. An electrode can be coupled to the pulse generator and configured to apply the stimulation signal to the neural tissue. A population of axons in the neural tissue can be recruited with each pulse of the stimulation signal.

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Номер записи: 48
12-03-2015 дата публикации

METHODS, SYSTEMS, AND DEVICES FOR PAIRING VAGUS NERVE STIMULATION WITH MOTOR THERAPY IN STROKE PATIENTS

Номер: US20150073492A1
Автор: ENGINEER Navzer, KILGARD Michael P., PIERCE David Michael, RENNAKER Robert L.
Принадлежит:

A method of treating motor deficits in a stroke patient, comprising assessing a patient's motor deficits, determining therapeutic goals for the patient, based on the patient's motor deficits, selecting therapeutic tasks based on the therapeutic goals, performing each of the selected therapeutic tasks repetitively, observing the performance of the therapeutic tasks, initiating the stimulation of the vagus nerve manually at approximately a predetermined moment during the performance of the therapeutic tasks, stimulating the vagus nerve of the patient during the performance of the selected therapeutic tasks, and improving the patient's motor deficits. 1. A method , comprising: exposing a patient to a plurality of therapeutic motions; and', "applying a plurality of vagus nerve stimulation pulse trains to the patient, respective trains of the plurality of trains being in temporal proximity to respective therapeutic motions of the plurality of therapeutic motions exposed to the patient to improve the patient's motor deficits."], 'treating one or more motor deficits via the actions of2. The method of claim 1 , further comprising:detecting a respective beginning of a therapeutic motion of the plurality of therapeutic motions; andapplying a respective vagus nerve stimulation pulse train of the plurality of pulse trains based on the detected beginning.3. The method of claim 1 , further comprising:automatically detecting a respective beginning of a therapeutic motion of the plurality of therapeutic motions; andautomatically applying a respective vagus nerve stimulation pulse train of the plurality of pulse trains based on the detected beginning.4. The method of claim 1 , further comprising:selecting a therapeutic task level for each therapeutic motion.5. The method of claim 1 , wherein the pulse trains are no longer than about 500 milliseconds in duration.6. The method of claim 1 , wherein the action of applying a plurality of vagus nerve stimulation pulse trains to the ...

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Номер записи: 49
12-03-2015 дата публикации

METHODS, SYSTEMS, AND DEVICES FOR PAIRING VAGUS NERVE STIMULATION WITH MOTOR THERAPY IN STROKE PATIENTS

Номер: US20150073493A1
Автор: ENGINEER Navzer, KILGARD Michael P., PIERCE David Michael, RENNAKER Robert L.
Принадлежит:

A method of treating motor deficits in a stroke patient, comprising assessing a patient's motor deficits, determining therapeutic goals for the patient, based on the patient's motor deficits, selecting therapeutic tasks based on the therapeutic goals, performing each of the selected therapeutic tasks repetitively, observing the performance of the therapeutic tasks, initiating the stimulation of the vagus nerve manually at approximately a predetermined moment during the performance of the therapeutic tasks, stimulating the vagus nerve of the patient during the performance of the selected therapeutic tasks, and improving the patient's motor deficits. 1. A method , comprising: directing a patient to execute a plurality of therapeutic motions; and', "applying a plurality of vagus nerve stimulation pulse trains to the patient, respective trains of the plurality of trains being in temporal proximity to execution of respective therapeutic motions of the plurality of therapeutic motions exposed to the patient to improve the patient's motor deficits."], 'treating motor deficits via the actions of2. The method of claim 1 , further comprising:detecting a respective beginning of a therapeutic motion of the plurality of therapeutic motions; andapplying a respective vagus nerve stimulation pulse train of the plurality of pulse trains based on the detected beginning.3. The method of claim 1 , further comprising:automatically detecting a respective beginning of a therapeutic motion of the plurality of therapeutic motions; andautomatically applying a respective vagus nerve stimulation pulse train of the plurality of pulse trains based on the detected beginning.4. The method of claim 1 , further comprising:selecting a therapeutic task level for each therapeutic motion.5. The method of claim 1 , wherein the pulse trains are no longer than about 500 milliseconds in duration.6. The method of claim 1 , wherein the action of applying a plurality of vagus nerve stimulation pulse trains to ...

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Номер записи: 50
29-05-2014 дата публикации

METHODS AND DEVICES FOR PERFORMING ELECTRICAL STIMULATION TO TREAT VARIOUS CONDITIONS

Номер: US20140148870A1
Автор: BURNETT Daniel R.
Принадлежит: EMKINETICS, INC.

In certain variations, systems and/or methods for electromagnetic induction therapy are provided. One or more ergonomic or body contoured applicators may be included. The applicators include one or more conductive coils configured to generate an electromagnetic or magnetic field focused on a target nerve, muscle or other body tissues positioned in proximity to the coil. One or more sensors may be utilized to detect stimulation and to provide feedback about the efficacy of the applied electromagnetic induction therapy. A controller may be adjustable to vary a current through a coil to adjust the magnetic field focused upon the target nerve, muscle or other body tissues based on the feedback provide by a sensor or by a patient. In certain systems or methods, pulsed magnetic fields may be intermittently applied to a target nerve, muscle or tissue without causing habituation. 1. (canceled)2. A method of performing electrical stimulation therapy , comprising:positioning a first portion of a patient's body relative to an electrical stimulator such that a target nerve within the first portion of the body is in proximity to the electrical stimulator;passing a current through the electrical stimulator;delivering an electrical stimulus from the electrical stimulator to the target nerve;detecting electrical conduction through the target nerve or detecting a muscular response caused by an electrical conduction through the target nerve via at least one sensor positioned along a second portion of the body;receiving a signal from the at least one sensor indicative of the detected electrical conduction or muscular response thereby providing feedback about the efficacy of the applied electrical stimulation therapy; andadjusting the current via a controller in communication with the electrical stimulator based on the feedback.3. The method of claim 2 , wherein the electrical stimulus is delivered to a posterior tibial nerve or branch thereof to treat fecal incontinence.4. The method ...

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Номер записи: 51
24-03-2022 дата публикации

METHODS AND DEVICES FOR PERFORMING ELECTRICAL STIMULATION TO TREAT VARIOUS CONDITIONS

Номер: US20220088373A1
Автор: BURNETT Daniel R.
Принадлежит: EMKINETICS, INC.

In certain variations, systems and/or methods for electromagnetic induction therapy are provided. One or more ergonomic or body contoured applicators may be included. The applicators include one or more conductive coils configured to generate an electromagnetic or magnetic field focused on a target nerve, muscle or other body tissues positioned in proximity to the coil. One or more sensors may be utilized to detect stimulation and to provide feedback about the efficacy of the applied electromagnetic induction therapy. A controller may be adjustable to vary a current through a coil to adjust the magnetic field focused upon the target nerve, muscle or other body tissues based on the feedback provide by a sensor or by a patient. In certain systems or methods, pulsed magnetic fields may be intermittently applied to a target nerve, muscle or tissue without causing habituation. 1. (canceled)2. A method of treating dysmenorrhea or menstrual cramps , comprising:non-invasively positioning a first portion of a patient's body relative to an electrical stimulator such that a branch of a posterior tibial nerve within the first portion of the body is directly targeted by the electrical stimulator;passing a current through the electrical stimulator; anddelivering an electrical stimulus from the electrical stimulator to the branch of the posterior tibial nerve such that the branch directly receives the electrical stimulation to treat dysmenorrhea or menstrual cramps.3. The method of wherein non-invasively positioning comprises positioning an electrode patch in communication with the electrical stimulator upon a foot of the patient.4. The method of further comprising detecting a muscular response caused by an electrical conduction or stimulation of the branch of the posterior tibial nerve.5. The method of wherein delivering the electrical stimulus comprises activating the electrical stimulator for a duration of about 30 minutes per week to treat the patient.6. The method of further ...

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Номер записи: 52
24-03-2022 дата публикации

USE OF A NEUROMODULATION SYSTEM

Номер: US20220088387A1
Автор: CABAN Miroslav
Принадлежит: ONWARD MEDICAL B.V.

A neuromodulation system can be used to treat a subject with at least one abnormal body function and/or disease comprising the treatment and/or modulation of at least one condition and/or function and/or dysfunction of the subject's gastrointestinal system, cardiovascular system, sensory system, urinary system, respiratory system, reproductive system, thermoregulation system and/or locomotor system. 113-. (canceled)14. A method for treating a subject , the method comprising the treatment or modulation , using a neuromodulation system , of one or more of: a condition , a function , or a dysfunction of the subject's respiratory system .15. The method of claim 14 , wherein the at least one condition claim 14 , function claim 14 , or dysfunction comprises one or more of: bronchial tree obstruction claim 14 , bronchial deficiency claim 14 , or alveolar deficiency.16. The method of claim 14 , wherein the at least one condition claim 14 , function claim 14 , or dysfunction comprises one or more of: chronic obstructive pulmonary disease claim 14 , a tumor claim 14 , trauma claim 14 , a stroke claim 14 , a damaged dorsal root claim 14 , a spinal cord injury claim 14 , or amyotrophic lateral sclerosis (ALS).17. The method of claim 14 , wherein the treatment or modulation comprises providing stimulation at least partially to the level of C3-C5 of the subject to treat one or more of: dyspnea claim 14 , spinal cord injury claim 14 , or chronic obstructive pulmonary disease.18. The method of claim 14 , wherein the treatment or modulation comprises providing stimulation at least partially to the level of T1-T6 of the subject.19. The method of claim 14 , wherein the treatment or modulation comprises providing stimulation at least partially to the level of T7-T12 of the subject.20. The method of claim 14 , wherein the treatment or modulation comprises treating claim 14 , or modulating an activity of claim 14 , one or more of: bronchia claim 14 , smooth muscles of the pulmonary ...

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Номер записи: 53
16-03-2017 дата публикации

Selective, Directable Electrotaxis of Precursor Cells with Biphasic Electrical Stimulation

Номер: US20170072201A1
Автор: Babona-Pilipos Robart, Morshead Cindi M., Popovic Milos R.
Принадлежит:

A method and system for enhancing migration of precursor cells in a desired direction, comprising applying a biphasic monopolar electrical field to the precursor cells. The method and system can be used to treat injury or disease of neural or skin tissue. 1. A method of enhancing migration of a precursor cell in a desired direction , comprising applying a biphasic monopolar electrical field having a cathode end and an opposing anode end to said precursor cell.2. (canceled)3. (canceled)4. (canceled)5. The method of wherein the biphasic monopolar electrical field is a charge balanced biphasic monopolar electrical field.6. The method of wherein the balanced biphasic monopolar electrical field comprises a negative phase and a positive phase claim 5 , wherein the negative phase has a greater amplitude than the positive phase claim 5 , and the positive phase has a greater duration than the negative phase claim 5 , charge-balancing said greater amplitude of said negative phase.7. (canceled)8. The method of wherein the negative phase and the positive phase are pulsatile phases.9. The method of wherein the negative phase and the positive phase are constant phases.10. The method of wherein the negative phase has an amplitude of between 2 to 5 mA and a pulse width of between 250 to 750 μs.11. (canceled)12. The method of wherein the negative phase yields an electric field strength of less than 500 mV/mm.13. (canceled)14. The method of wherein the charge balanced biphasic monopolar electrical field has a frequency of between 100 to 1000 Hz.15. (canceled)16. The method of wherein the charge balanced biphasic monopolar electrical field comprises a negative phase and a positive phase claim 5 , wherein the positive phase has a greater amplitude than the negative phase claim 5 , and the negative phase has a greater duration than the positive phase claim 5 , charge-balancing said greater amplitude of said positive phase.17. (canceled)18. The method of wherein the positive phase has an ...

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Номер записи: 54
12-03-2020 дата публикации

Electromyographic Lead Positioning and Stimulation Titration in a Nerve Stimulation System for Treatment of Overactive Bladder

Номер: US20200078594A1
Автор: JIANG GUANGQIANG, Schmid Eric, Schroeder Dennis, Woock John
Принадлежит:

The present invention provides improved methods for positioning of an implantable lead in a patient with an integrated EMG and stimulation clinician programmer. The integrated clinician programmer is coupled to the implantable lead, wherein the implantable lead comprises at least four electrodes, and to at least one EMG sensing electrode minimally invasively positioned on a skin surface or within the patient. The method comprises delivering a test stimulation at a stimulation amplitude level from the integrated clinician programmer to a nerve tissue of the patient with a principal electrode of the implantable lead. Test stimulations are delivered at a same stimulation amplitude level for a same period of time sequentially to each of the four electrodes of the implantable lead. A stimulation-induced EMG motor response is recorded with the integrated clinician programmer for each test stimulation on each electrode of the implantable lead via the at least one pair of EMG sensing electrodes so as to facilitate initial positioning of the implantable lead at a target stimulation region. 1. (canceled)2. A method for improved positioning of an implantable neurostimulation lead in a patient with a clinician programmer coupled to the implantable neurostimulation lead comprising a plurality of neurostimulation electrodes , wherein at least one EMG sensing electrode is minimally invasively positioned on a skin surface or within the patient , the method comprising:delivering a first test stimulation at a stimulation amplitude level from the clinician programmer to a nerve tissue of the patient with a principal neurostimulation electrode of the implantable neurostimulation lead, wherein the principal neurostimulation electrode is selected from the plurality of neurostimulation electrodes of the implantable neurostimulation lead;delivering one or more second test stimulations at the same stimulation amplitude level as the first test stimulation sequentially to each remaining ...

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Номер записи: 55
12-06-2014 дата публикации

HIGH DENSITY EPIDURAL STIMULATION FOR FACILITATION OF LOCOMOTION, POSTURE, VOLUNTARY MOVEMENT, AND RECOVERY OF AUTONOMIC, SEXUAL, VASOMOTOR, AND COGNITIVE FUNCTION AFTER NEUROLOGICAL INJURY

Номер: US20140163640A1
Автор: Angeli Claudia A., Burdick Joel W., Desautels Thomas Anthony, EDGERTON Victor Reggie, GERASIMENKO Yury, Harkema Susan J., Hodes Jonathan, Nandra Mandheerej S., ROY Roland R., Tai Yu-Chong
Принадлежит:

Methods of enabling locomotor control, postural control, voluntary control of body movements (e.g., in non-weight bearing conditions), and/or autonomic functions in a human subject having spinal cord injury, brain injury, or neurological neuromotor disease. In certain embodiments, the methods involve stimulating the spinal cord of the subject using an epidurally placed electrode array, subjecting the subject to physical training thereby generating proprioceptive and/or supraspinal signals, and optionally administering pharmacological agents to the subject. The combination of stimulation, physical training, and optional pharmacological agents modulate in real time electrophysiological properties of spinal circuits in the subject so they are activated by supraspinal information and/or proprioceptive information derived from the region of the subject where locomotor activity is to be facilitated. 1. A method comprising:positioning a human patient in a training device, the patient having a neurologically derived paralysis in a portion of the patient's body, the training device being configured to assist with physical training that is configured to induce neurological signals in the portion of the patient's body having the paralysis, the patient having a spinal cord with at least one selected spinal circuit that has a first stimulation threshold representing a minimum amount of stimulation required to activate the at least one selected spinal circuit, and a second stimulation threshold representing an amount of stimulation above which the at least one selected spinal circuit is fully activated and adding the induced neurological signals has no additional effect on the at least one selected spinal circuit, the induced neurological signals being below the first stimulation threshold and insufficient to activate the at least one selected spinal circuit; andapplying electrical stimulation to a portion of a spinal cord of the patient, the electrical stimulation being below ...

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Номер записи: 56
29-03-2018 дата публикации

SKULL IMPLANTED ELECTRODE ASSEMBLY FOR BRAIN STIMULATION

Номер: US20180085573A1
Автор: Alam Imran Khurshid
Принадлежит:

A skull-implantable electrode assembly for delivering pulses of electric current to a patient's brain, comprising an electrode housed in an insulated conduit and threaded through an electrically-conductive cannulated skull screw. Details of the exterior construction are discussed, as well as electrode arrangements and methods of treating a medical ailment of a patient. 1: An implantable electrode assembly comprising:an electrically-conductive cannulated skull screw with a head end and a point end, which is configured to transverse a skull of a patient with the point end located at the interior surface of the skull and the head end at the exterior surface of the skull;an electronics module comprising a casing, wherein the electronics module is electrically connected to the head end of the skull screw and wherein the casing is in direct contact with the head end of the skull screw; anda conductor housed in an insulated conduit and threaded through the skull screw, said conductor comprising a connection end and an electrode end, with the connection end located at the head end of the skull screw and electrically connected to the electronics module, and the electrode end configured to form an electrical connection with a brain tissue of the patient.2: The assembly of wherein the electrode end of the conductor is configured to form at least two electrical connections with different locations of the patient's brain tissue.3: The assembly of further comprising a plurality of conductive discs housed within a flexible insulator with 1-20 mm spacing claim 2 , wherein the electrode end is electrically connected to the conductive discs to form at least two electrical connections with different locations of the patient's brain tissue.4: The assembly of wherein the electronics module further comprises a photovoltaic power supply.5: The assembly of wherein the electronics module further comprises a battery and a computer chip claim 1 , wherein an exterior surface of the casing ...

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Номер записи: 57
29-03-2018 дата публикации

VAGUS NERVE STIMULATION FOR TREATING SPINAL CORD INJURY

Номер: US20180085578A1
Автор: GANZER Patrick D., HAYS Seth A., II Robert L., KILGARD Michael P., Rennaker
Принадлежит:

Provided herein are methods for the treatment of spinal cord injury in a subject by administering vagus nerve stimulation. In particular, the vagus nerve stimulation is administered in combination with conventional rehabilitation training. 1. A method of treating a spinal cord injury in a subject comprising applying an electrical signal to a vagus nerve of said subject.2. The method of claim 1 , wherein treating results in increased in neural plasticity claim 1 , increased motor circuit connectivity claim 1 , improved motor function claim 1 , improved sensory function claim 1 , enhanced voluntary motor control claim 1 , and/or prevention of secondary injury and/or wherein treating results in at least a 50% improvement in motor function.3. (canceled)4. The method of claim 1 , wherein the electrical signal is administered in combination with rehabilitation.5. The method of claim 1 , wherein the electrical signal is administered concurrent with rehabilitation.6. The method of claim 1 , wherein the rehabilitation comprises physical therapy.7. The method of claim 1 , wherein the electrical signal is administered 1 day to 10 years after the spinal cord injury.8. The method of claim 1 , wherein the spinal cord injury is caused by contusion of the spinal cord claim 1 , bruising of the spinal cord claim 1 , loss of blood to the spinal cord claim 1 , pressure on the spinal cord claim 1 , cut spinal cord claim 1 , severed spinal cord or is the result of a physical trauma claim 1 , infection claim 1 , insufficient blood flow claim 1 , or a tumor.9. (canceled)10. The method of claim 1 , wherein the spinal cord injury is complete spinal cord injury or incomplete spinal cord injury.11. (canceled)12. The method of claim 1 , wherein the spinal cord injury is at one or more of the cervical vertebrae claim 1 , thoracic vertebrae claim 1 , lumbar vertebrae claim 1 , or sacral vertebrae.13. The method of claim 1 , wherein the electrical signal is monophasic claim 1 , biphasic claim 1 , ...

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Номер записи: 58
29-03-2018 дата публикации

ANATOMICAL TARGETING OF NEUROMODULATION

Номер: US20180085583A1
Автор: Hershey Bradley Lawrence, Moffitt Michael A., Zhang Tianhe
Принадлежит:

A neuromodulation targeting system includes a GUI that facilitates selection of one or more neuromodulation target regions. The GUI provides an interactive display representing anatomy of a patient with user-selectable portions corresponding to a plurality of predefined anatomical regions associated with distinct localized clinical effects of neuromodulation. The system further includes a targeting selector engine that is responsive to user selection of a first portion of the interactive display by configuring delivery of neuromodulation therapy to a first target region to produce a first localized clinical effect in the patient at a location corresponding to the first portion of the display, upon administration of the neuromodulation therapy to the patient. 1. A neuromodulation targeting system facilitating spatial selection of a neuromodulation objective , the system comprising:a graphical user interface (GUI) that includes an interactive display representing anatomy of a patient with user-selectable anatomic-specific inputs associated with a plurality of predefined neural pathways corresponding to distinct localized clinical effects of neuromodulation; and computationally determine a first target region where neuromodulation therapy is to be directed, the first target region being distinct from an anatomic location of the anatomic-specific input, and', 'configure delivery of the neuromodulation therapy to the first target region to produce a first localized clinical effect in the patient at a location corresponding to the first anatomic-specific input, upon administration of the neuromodulation therapy to the patient, to achieve the neuromodulation objective., 'a targeting selector engine operatively coupled with the GUI, the targeting selector engine being responsive to user selection of a first anatomic-specific input to2. The neuromodulation targeting system of claim 1 , wherein the first target region is a neuroanatomic region selected from the group ...

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Номер записи: 59
29-03-2018 дата публикации

ONSET-MITIGATING HIGH-FREQUENCY NERVE BLOCK

Номер: US20180085587A1
Автор: BHADRA Niloy, Kilgore Kevin L.
Принадлежит:

A method of blocking signal transmission through a nerve with reduced onset activity includes applying an HFAC to an axon of a nerve to block the transmission of signals through the axon. The method may also include applying a direct current (DC) to the axon, increasing the amplitude of the DC over time to a predetermined amplitude, applying the HFAC, and then decreasing the DC. The method may also include temporarily reducing the amplitude of the HFAC to permit the transmission of signals through the axon and subsequently increasing the amplitude to block transmission without triggering an onset response. The method may also include temporarily applying an unbalanced charge to the nerve and then balancing the charge over time. 138.- (canceled)39. A system , comprising:at least one sensor to detect a signal from a biological component, wherein the signal is indicative of a biological process;a controller coupled to the at least one sensor to receive an indication of the signal from the at least one sensor and comprising a processor to determine whether nerve block is required by the biological process based on the indication of the signal from the at least one sensor;a waveform generator coupled to the controller to configure a nerve block signal when the controller sends instructions indicating that the nerve block is required by the biological process; andan electrode coupled to the waveform generator to apply the nerve block signal to a nerve associated with the biological process,wherein the nerve block signal comprises an onset mitigating combination of blocking waveforms.40. The system of claim 39 , wherein the biologocal process is related to at least one of torticollis claim 39 , neuroma pain claim 39 , hiccups claim 39 , muscular dystrophy claim 39 , cancer pain claim 39 , post-operative pain claim 39 , chronic pain claim 39 , pain claim 39 , and stroke.41. The system of claim 39 , further comprising at least two sensors claim 39 , each to detect different ...

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Номер записи: 60
05-04-2018 дата публикации

SYSTEM TO DELIVER ADAPTIVE EPIDURAL AND/OR SUBDURAL ELECTRICAL SPINAL CORD STIMULATION TO FACILITATE AND RESTORE LOCOMOTION AFTER A NEUROMOTOR IMPAIRMENT

Номер: US20180093093A1
Автор: BONIZZATO Marco, Courtine Gregoire, MICERA Silvestro, MORAUD Eduardo Martin, Wenger Nikolaus
Принадлежит:

The present disclosure provides a closed-loop system for real-time control of epidural and/or subdural electrical stimulation comprising means for applying to a subject neuromodulation with adjustable stimulation parameters, said means being operatively connected with a real-time monitoring component comprising sensors continuously acquiring feedback signals from said subject, said signals being neural signals and/or signals providing features of motion of said subject, said system being operatively connected with a signal processing device receiving said feedback signals and operating real-time automatic control algorithms, said signal processing device being operatively connected with said means and providing said means with new stimulation parameters, with minimum delay. The system of the disclosure improves consistency of walking in a subject with a neuromotor impairment. A Real Time Automatic Control Algorithm is used, comprising a feedforward component employing a single input-single output model (SISO), a multiple input-single output (MISO) model, or a multiple input-multiple output (MIMO) model. 1. A system for determining optimal stimulation parameters for a subject suffering from a neuromotor impairment and undergoing a process for facilitating locomotor functions comprising:an epidural and/or subdural electrical stimulation device for applying electrical stimulation with adjustable stimulation parameters;one or more sensors;a real-time monitoring system; and 'acquire feedback signals from said real-time monitoring system, where said real-time monitoring system receives signals from said sensors, said signals being neural signals and/or signals providing features of motion of said subject;', 'a signal processing device, operating a program comprising an automatic control algorithm that interfaces simultaneously with a data flow from the real-time monitoring system and the epidural and/or subdural electrical stimulation device tocalculate stimulation ...

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Номер записи: 61
28-03-2019 дата публикации

NEUROMIMETIC STIMULATING APPARATUS AND METHOD

Номер: US20190091470A1
Автор: KIM Jongpal, Kim Sang Joon, Lee Hyungwoo
Принадлежит: SAMSUNG ELECTRONICS CO., LTD.

A neuromimetic stimulating apparatus includes a feedback detector configured to detect a feedback signal from a target to be stimulated, a controller configured to analyze a waveform of the detected feedback signal and determine a parameter based on the analyzed waveform of the detected feedback signal, and a signal generator configured to generate a stimulus signal corresponding to the detected feedback signal based on the determined parameter. 1. A stimulating apparatus comprising:a feedback detector configured to detect a feedback signal from a target to be stimulated;a controller configured to analyze a waveform of the detected feedback signal and determine a parameter based on the analyzed waveform of the detected feedback signal; anda signal generator configured to generate a stimulus signal corresponding to the detected feedback signal based on the determined parameter.2. The stimulating apparatus of claim 1 , wherein the controller is further configured to determine a neural response indicated by the detected feedback signal based on the analyzed waveform of the detected feedback signal claim 1 , and determine the parameter based on the determined neural response.3. The stimulating apparatus of claim 2 , wherein the controller is further configured to determine the neural response indicated by the detected feedback signal by obtaining the neural response indicated by the detected feedback signal from a data set storing feedback signals and neural responses mapped to the feedback signals based on the analyzed waveform of the detected feedback signal.4. The stimulating apparatus of claim 3 , wherein the feedback signals stored in the data set are obtained by exposing the target to environments that induce the neural responses stored in the data set.5. The stimulating apparatus of claim 2 , wherein the controller is further configured to determine the parameter by obtaining a stimulus signal corresponding to the determined neural response from a data set ...

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Номер записи: 62
14-04-2016 дата публикации

SYSTEMS AND METHODS FOR TREATING SEXUAL DISORDERS USING ELECTRO-STIMULATION

Номер: US20160101288A1
Автор: FRAGA DA SILVA Rodrigo Araujo, STERGIOPULOS Nikolaos
Принадлежит: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)

Systems and methods are provided for treating a sexual disorder such as erectile dysfunction (ED) or female sexual arousal disorder (FSAD). An electrical stimulation system may include an implantable stimulation unit, an external patient controller, and an external physician controller. The implantable stimulation unit has an array of electrodes disposed on one or more flexible substrates configured to conform to a patient's anatomy at the pelvic plexus. Post-implantation, the physician controller may direct the stimulation unit to stimulate with select electrode(s) of the array to determine which electrode configuration provides optimal sexual arousal. The patient controller may be used to cause the stimulation unit to stimulate using the optimal electrode configuration at desired times. 1. An electrical stimulation system for treatment of erectile dysfunction in a patient , the system comprising: an array of electrodes disposed on at least one flexible substrate sized and shaped to abut at least a portion of a pelvic plexus of a patient;', 'a programmable controller operatively coupled to the array of electrodes, the programmable controller including a stimulation circuit, a nonvolatile memory and a microprocessor coupled to the stimulation circuit and the nonvolatile memory,', 'wherein the nonvolatile memory stores an identity of an empirically determined subset of the array of electrodes and a stimulation routine used by the microprocessor to supply electrical stimulation via the stimulation circuit and the pelvic plexus to at least one cavernous nerve sufficient to cause an erection; and, 'an implantable stimulation unit comprisingan external patient controller configured to selectably activate the implantable stimulation unit responsive to a patient input; andan external physician controller configured to selectively activate desired subsets of the array of electrodes to determine the empirically determined subset of the array of electrodes and to cause the ...

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Номер записи: 63
26-06-2014 дата публикации

ELECTROSTIMULATION IN TREATING CEREBROVASCULAR CONDITIONS

Номер: US20140180307A1
Автор: Beinart Yiftach, Levy Ronnie, Shalev Alon
Принадлежит:

A system for treating a medical condition in a living body, comprising two subsystems, an implant subsystem and an electrical stimulation unit subsystem. The implant subsystem comprises at least one electrostimulation module, contains at least one electrically conductive electrode and, preferably, an anchoring member. The electrical stimulation unit, adapted for producing and controlling electrical waveforms, is connected to the electrodes. The implant subsystem is implanted adjacent to at least one of the following structures: the carotid sinus nerve, aortic nerve, common carotid artery, external carotid artery, internal carotid artery, carotid artery bifurcation, carotid body, aortic body or aortic arch receptors. The electrical stimulation unit is maintained outside the patient's body and is adapted to program, generate, control and deliver the electrical waveform via a wired or a wireless connection to the implant subsystem, thereby stimulating the structure it is adjacent to and treating the medical condition. 1. A system for treating a medical condition in a living body of a patient , comprising:a. at least one implant, adapted to be retrievably implanted in said patient; said implant comprising: at least one electrostimulation module comprising a proximal end and a distal end, said distal end comprising at least one first distal end member; and at least one electrically conductive electrode mounted in said at least one first distal end member; andb. at least one electrical stimulation unit, adapted for producing an electrical waveform and connected to at least one of said electrodeswherein said implant is implanted adjacent to at least one of the group consisting of: the carotid sinus nerve, the aortic nerve, the common carotid artery, the external carotid artery, internal carotid artery, carotid artery bifurcation, carotid body, aortic body, aortic arch receptors and any combination thereof within said living body; further wherein said electrical stimulation ...

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Номер записи: 64
26-06-2014 дата публикации

NEUROSTIMULATOR

Номер: US20140180361A1
Автор: Angeli Claudia A., Burdick Joel W., Desautels Thomas Anthony, EDGERTON Victor Reggie, GERASIMENKO Yury, Harkema Susan J., Hodes Johnathan, Jackson Douglas J., JR. Nicholas A., Keynton Robert S., Naber John F., Nandra Mandheerej S., ROY Roland R., Tai Yu-Chong, Terrafranca, Upchruch Steven L.
Принадлежит:

A neurostimulator device for use with groups (e.g., more than four groups) of electrodes. The neurostimulator may include a stimulation assembly configured to deliver different stimulation to each of the groups. The neurostimulator may also include at least one processor configured to direct the stimulation assembly to deliver stimulation to the groups. The stimulation delivered to at least one of the groups may include one or more waveform shapes other than a square or rectangular wave shape. The processor may receive data from one or more sensors and use that data to modify the stimulation delivered. The neurostimulator may be configured to communicate with an external computing device. The neurostimulator may send data to and/or receive data and/or instructions from the computing device. The computing device may use information collected by one or more sensors to at least partially determine stimulation parameters to communicate to the neurostimulator. 151-. (canceled)52. A device for use with a plurality of electrodes , and one or more sensors , the device comprising:a stimulation assembly connectable to the plurality of electrodes, the stimulation assembly being configured to deliver stimulation to selected ones of the plurality of electrodes when the stimulation assembly is connected to the plurality of electrodes;a sensor interface connectable to the one or more sensors, the sensor interface being configured to receive signals from the one or more sensors when the sensor interface is connected to the one or more sensors;at least one processor connected to both the stimulation assembly and the sensor interface, the at least one processor being configured to direct the stimulation assembly to deliver at least one complex stimulation pattern to the selected ones of the plurality of electrodes, and to receive the signals from the sensor interface, the at least one processor being further configured to modify the at least one complex stimulation pattern delivered ...

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Номер записи: 65
08-04-2021 дата публикации

NERVE REGENERATION SYSTEM AND METHOD

Номер: US20210101011A1
Автор: COSENTINO Leonard M., Scanlan Kevin, WALKER Eric R.
Принадлежит:

A stimulation device includes an adaptor component. The adaptor component couples a percutaneous lead to the stimulation device. The stimulation device may apply a stimulation signal to target tissue via the adaptor. A surgeon may place the stimulation device in a container and the adaptor component may be disposed outside of the container. Methods describe prolonged stimulation of target tissue via a stimulation device. The prolonged stimulation may be applied during and after a surgical procedure. 1. An electrical stimulation system , comprising: a housing;', 'control circuitry operatively generating a stimulation current, wherein the control circuitry is disposed within the housing;', 'at least one operative element coupled with the housing and comprising at least one electrode;, 'a stimulation device comprisinga lead electrically coupled to the stimulation device through the at least one electrode, the percutaneous lead insertable into a patient during a surgery and after the surgery and wherein the stimulation device is capable of applying electrical stimulation during the surgery.2. The electrical stimulation system of claim 1 , wherein the control circuitry applies the electrical stimulation during the surgery to accelerate or improve nerve recovery.3. The electrical stimulation system of further comprising an adaptor selectively attached to the operative element claim 1 , wherein the adaptor includes the lead.4. The electrical stimulation system of claim 1 , wherein the stimulation device is capable of applying electrical stimulation after the surgery.5. The electrical stimulation system of claim 1 , wherein the control circuitry applies the electrical stimulation for a period between one minute and eight hours.6. The electrical stimulation system of further comprising a container operatively receiving the stimulation device claim 1 , wherein the container comprises at least one connection port that operatively and electrically couples the stimulation device ...

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Номер записи: 66
13-04-2017 дата публикации

METHODS, SYSTEMS, AND DEVICES FOR PAIRING VAGUS NERVE STIMULATION WITH MOTOR THERAPY IN STROKE PATIENTS

Номер: US20170100590A1
Автор: ENGINEER Nazer, KILGARD Michael P., PIERCE David Michael, RENNAKER Robert L.
Принадлежит:

A method of treating motor deficits in a stroke patient, comprising assessing a patient's motor deficits, determining therapeutic goals for the patient, based on the patient's motor deficits, selecting therapeutic tasks based on the therapeutic goals, performing each of the selected therapeutic tasks repetitively, observing the performance of the therapeutic tasks, initiating the stimulation of the vagus nerve manually at approximately a predetermined moment during the performance of the therapeutic tasks, stimulating the vagus nerve of the patient during the performance of the selected therapeutic tasks, and improving the patient's motor deficits. 1. A method , comprising:treating motor deficits via the actions of:directing a patient to execute a therapeutic motion; andapplying a vagus nerve stimulation pulse train of electrical stimulation energy to the patient, the pulse train being in temporal proximity to execution of the therapeutic motion to improve the patient's motor deficits.2. The method of wherein the pulse train is delivered for a period of time during the therapeutic motion claim 1 , and the period of time has a duration that is different than a duration of the therapeutic motion.3. The method of wherein the respective vagus nerve stimulation pulse train is delivered for a period of time during the therapeutic motion claim 1 , and the period of time has a duration that is less than a duration of the therapeutic motion.4. The method of wherein the pulse train is a plurality of pulse trains.5. The method of wherein the therapeutic motion is a plurality of therapeutic motions.6. The method of wherein the pulse train is applied during the therapeutic motion.7. A method claim 1 , comprising:treating motor deficits via the actions of:directing a patient to execute a series of therapeutic motions; andapplying a series of vagus nerve stimulation pulse trains of electrical stimulation energy to the patient, the series of pulse trains being in temporal proximity ...

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Номер записи: 67
13-04-2017 дата публикации

METHODS AND ASSOCIATED NEURAL PROSTHETIC DEVICES FOR BRIDGING BRAIN AREAS TO IMPROVE FUNCTION

Номер: US20170100591A1
Автор: Azin Meysam, Guggenmos David, Mohseni Pedram, Nudo Randolph J.
Принадлежит:

Methods for bridging brain sites between which there is substantially no effective communication, and associated neural prosthetic devices, are provided. A neural spike in a first neural site in a subject is detected, and a stimulus to a second neural site in the subject is delivered within a defined period of time after the detection of the neural spike, wherein there is substantially no effective communication between the first and second neural sites. The method forms an artificial bridge between the two neural sites, and establishes lasting communication between the two sites. The present disclosure provides, among other things, a neural prosthetic device comprising an integrated circuit that comprises a recording front-end comprising a plurality of recording channels; a processor unit; and a stimulus delivering back-end comprising a plurality of stimulation channels. 1. A method comprising:detecting a neural spike in a first neural site in a subject; anddelivering a stimulus to a second neural site in the subject within a defined period of time after the detection of the neural spike, wherein there is substantially no effective communication between the first and second neural sites.2. The method of wherein the first neural site claim 1 , the second neural site claim 1 , or both are located in a cortical region of the subject.3. The method of wherein the first neural site claim 1 , the second neural site claim 1 , or both are located in the spinal cord of the subject.4. The method of wherein the stimulus is an electrical pulse.5. The method of wherein the electrical pulse is monophasic or biphasic.6. The method of wherein delivering the stimulus occurs less than 5 ms after a neural spike is detected in the first neural site or less than 1000 ms after a neural spike is detected in the first neural site.7. The method of further comprising:using a neural prosthetic device to deliver the stimulus to the second neural site, wherein the neural prosthetic device ...

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Номер записи: 68
04-04-2019 дата публикации

THERAPY PARAMETER SELECTION BASED ON ECAP FEEDBACK

Номер: US20190099601A1
Автор: Torgerson Nathan A.
Принадлежит:

Techniques for therapy delivery are described. A processing circuit may adjust a first therapy parameter from a first level to a second level, and responsive to the adjustment of the first therapy parameter, compare a level of an evoked compound action potential (ECAP) generated from therapy delivery based on the adjusted first therapy parameter to an ECAP threshold. The processing circuit may adjust a second therapy parameter from a third level to a fourth level based on the comparison. The second therapy parameter is different than the first therapy parameter. The processing circuit may cause therapy delivery with the first therapy parameter at the second level and the second therapy parameter at the fourth level. 1. A method of therapy delivery , the method comprising:adjusting a first therapy parameter from a first level to a second level different than the first level;responsive to the adjustment of the first therapy parameter, comparing a level of an evoked compound action potential (ECAP) generated in response to therapy delivered with the adjusted first therapy parameter to an ECAP threshold;adjusting a second therapy parameter from a third level to a fourth level different than the third level based on the comparison, wherein the second therapy parameter is different than the first therapy parameter; andcausing delivery of the therapy with the first therapy parameter at the second level and the second therapy parameter at the fourth level.2. The method of claim 1 , further comprising:determining that the level of the ECAP is greater than the ECAP threshold based on the comparison,wherein adjusting the second therapy parameter comprises, responsive to determining that the level of the ECAP is greater than the ECAP threshold, adjusting the second therapy parameter from the third level to the fourth level, wherein the level of the ECAP is less than or equal to the ECAP threshold when the therapy is delivered with the second therapy parameter at the fourth ...

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Номер записи: 69
03-07-2014 дата публикации

Method and Apparatus to Increase Tactile Senstivity and Proprioception in Humans

Номер: US20140188194A1
Автор: Eric Anthony Schepis, Kaiyuan Yang, Martha Lillian Tate, Martin S. Shamis, Matthew John Valaskey, Shawn Jeffery Sullivan, WonYeong Sohn
Принадлежит: Kimberly Clark Worldwide Inc

The article is a support to which an electrode pair, a positive and corresponding negative electrode, is attached. Leads are electrically attached to each of the positive and negative electrodes, wherein each lead has an insulated coating. A controller is electrically attached to the leads for delivering monophasic or biphasic electrical stimulation at a single frequency. A power supply is electrically connected to the controller, and may be attached to the support. The article may be a sock, a glove, a harness or an insole.

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Номер записи: 70
09-06-2022 дата публикации

SYSTEM FOR IMPROVING NEUROSTIMULATION TREATMENT COMPLIANCE WITH GAMIFICATION

Номер: US20220176118A1
Автор: John Michael Sasha, YOO PAUL B.
Принадлежит:

Gamification for a pelvic disorder regimen has a processor for operating a control module configured to define a programmable treatment regimen. A neurostimulator is connected to the processor and the control module. The neurostimulator applies electrical or magnetic signals to the user according to the programmable treatment regimen which includes at least one treatment task to be performed by the user. A gramification module calculates and stores a set of scores of the user in performing at least one task defined in the programmable treatment program associated with one or more events defined in the programmable treatment program to provide a score assigned to each task performance. A user interface is connected to the control module and provides the user with information associated with the scores attained by the user. 1. A system for gamification of a pelvic disorder treatment regimen that includes the provision of neurostimulation comprising:at least a first processor configured for operating a control module, said control module configured to define a programmable treatment regimen for treatment of a user having a pelvic disorder;at least one neurostimulator coupled to said control module and said processor, said neurostimulator adapted to provide electrical or magnetic stimulation signals to said user in accordance with said programmable treatment regimen having at least one set of scheduled events requiring said user to perform at least one treatment task associated with a respective event of said at least one set of scheduled events, said neurostimulator further configured to communicate data or control signals to and from the at least one first processor;a gamification module configured for calculating and storing at least one score of said user in performance of said at least one treatment task associated with said respective event; and,at least one user interface module coupled to the control module, said user interface module being configured to provide ...

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Номер записи: 71
30-04-2015 дата публикации

ELECTRICAL STIMULATION THERAPY FOR LOWER URINARY TRACT DYSFUNCTION AND SEXUAL REFLEX DYSFUNCTION

Номер: US20150119951A1
Автор: Brink Thaddeus S., Hedstrom Blake A., Nelson Dwight E., Su Xin
Принадлежит:

Electrical stimulation therapy may be delivered to a patient to selectively and independently address different conditions of a pelvic floor disorder of the patient. The conditions of a pelvic floor disorder may include, for example, a lower urinary tract dysfunction (e.g., urinary or fecal incontinence) and sexual dysfunction (e.g., an impaired sexual reflex response to a sexual stimulus). In some examples, a system is configured to selectively deliver a first electrical stimulation therapy that is configured to elicit an inhibitory physiological response from the patient related to voiding, a second electrical stimulation therapy that is configured to improve a sexual reflex response of the patient to a sexual stimulus, and a third electrical stimulation therapy that is configured to both elicit the inhibitory physiological response from the patient related to voiding and increase a sexual response of the patient to a sexual stimulus. 1. A method comprising:with a processor, receiving user input;with the processor, selecting, based on the user input, one of a first electrical stimulation therapy configured to elicit an inhibitory physiological response from the patient related to voiding, a second electrical stimulation therapy configured to increase a sexual response of the patient to a sexual stimulus compared to a physiological state of the patient elicited by the first electrical stimulation therapy, or a third electrical stimulation therapy configured to elicit the inhibitory physiological response from the patient related to voiding, and, compared to the physiological state of the patient elicited by the first electrical stimulation therapy, increase the sexual response of the patient to the sexual stimulus; andwith the processor, controlling a medical device to deliver the selected one of the first electrical stimulation therapy, the second electrical stimulation therapy or the third electrical stimulation therapy to the patient.2. A system comprising:a ...

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Номер записи: 72
03-05-2018 дата публикации

External Pulse Generator Device and Associated Methods for Trial Nerve Stimulation

Номер: US20180117344A1
Автор: KARTEN Stuart, MATHUR PRABODH, Sama Rinda, Schmid Eric, Schroeder Dennis
Принадлежит:

Systems and methods for providing a trial neurostimulation to a patient for assessing suitability of a permanently implanted neurostimulation are provided herein. In one aspect, a trial neurostimulation system includes an EPG patch adhered to a skin surface of a patient and connected to a lead extending through a percutaneous incission to a target tissue location. The EPG may be a modified version of the IPG used in the permanent system, the EPG may be smaller and/or lighter than the corresponding IPG device. The EPG and a lead extension may be sealed to allow improved patient mobility and reduced risk of infection. The EPG may be compatible with wireless systems used to control and monitor the IPG such that operation and control of the EPG is substantially the same in each system to allow seemless conversion to the permantly implanted system. 1. A neurostimulation system comprising:an implantable neurostimulation lead having one or more conductors extending from a proximal end of the lead to one or more neurostimulation electrodes disposed at or near a distal end of the lead;an external pulse generator electrically coupleable to the implantable lead, the pulse generator being electrically coupled with the one or more neurostimulation electrodes when electrically coupled with the implantable lead, wherein the pulse generator is configured to generate a plurality of electrical impulses for delivering a trial neurostimulation treatment to a patient through the one or more neurostimulation electrodes when implanted at a target location; andan implantable pulse generator adapted to deliver a neurostimulation therapy through the one or more neurostimulation electrodes of the implantable neurostimulation lead based on the trial neurostimulation treatment, wherein the external pulse generator is smaller and/or lighter than the implantable pulse generator.2. The system of wherein the implantable pulse generator is configured to operate while implanted for one or more years ...

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Номер записи: 73
17-07-2014 дата публикации

SYSTEM FOR STIMULATING BONE GROWTH, TISSUE HEALING AND/OR PAIN CONTROL, AND METHOD OF USE

Номер: US20140200616A1
Автор: Leuthardt Eric C., MacEwan Matthew R., Moran Daniel W.
Принадлежит:

A system for use in stimulating bone growth, tissue healing, and/or pain control is described. The system includes a screw, a battery, a controller, and means for connecting the battery such that current is routed from the battery through the screw and thence to a target area of interest requiring treatment. The screw includes an elongate shaft having a length extending between opposite ends. The shaft has an insulating coating extending along at least a portion of the length. The thickness of the insulating coating at various portions of the shaft is modulated to optimally direct current to a target area of interest requiring treatment. The controller adjusts the duty cycle of the current flow over the treatment period. 1. A screw for use in stimulating at least one of bone growth , tissue healing , and pain control comprising:an elongate shaft having a length extending between opposite ends, an exterior surface, and a screw thread formed on the exterior surface of the shaft and extending along at least a portion of the length of the shaft, said shaft having an insulating coating extending along at least a portion of the length of the shaft;a head adjacent one end of the shaft for engaging the screw to rotate the screw and thereby drive it into bone; andan electrical conductor electrically connectable to the shaft for conveying current through the shaft,wherein a thickness of the insulating coating at a first portion of the shaft is greater than a thickness of the insulating coating at a second portion of the shaft.2. The screw set forth in claim 1 , wherein the insulating coating decreases in thickness linearly along the length of the shaft from the first portion to the second portion.3. The screw set forth in claim 1 , wherein the insulating coating decreases in thickness exponentially along the length of the shaft from the first portion to the second portion.4. The screw set forth in claim 1 , wherein a thickness of the insulating coating at a third portion of ...

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Номер записи: 74
04-05-2017 дата публикации

Programming Adjustment for Brain Network Treatment

Номер: US20170120043A1
Автор: John Michael Sasha
Принадлежит:

The present invention involves methods and systems for treatment of brain disorders using neuromodulation of brain networks. Implantation occurs by selecting sites which modulate the network in selected manners, or are modulated by a stimulus in a particular manner that is relevant to treatment of the network. The candidate locations within a brain region are evaluated in relation to how these are indirectly modulated by stimulation at a different brain region. Treatment of one or more brain networks associated with a brain disorder is realized with a consideration of network dynamics and coupling effects such as indirect stimulation of non-target regions. A brain modulation system (BMS) increases, decreases, or otherwise modulates network regional activity in a differential manner. Therapy and electrode locations are adjusted using sensed data and target implantation criteria related to the brain network model. Linking rules be derived during the implantation procedure and used in the subsequent adjusting of the therapy of regions of a brain network. 1. A method comprising:defining, using a processor, a model of a network of connected brain structures of a patient, wherein the model of the network includes at least one value indicating a functional interaction between at least a first brain structure and a second brain structure;sensing activity in at least the first brain structure, the activity occurring in response to at least one therapy selected from the group of an electrical, magnetic or drug therapy delivered to the second brain structure; and,adjusting, based on the sensed activity, at least one of: the functional interaction between the first brain structure, or the second brain structure and the therapy delivered to the second brain structure.2. The method of claim 1 , wherein the functional interaction between the first and second brain structures is assessed for an individual patient.3. The method of claim 2 , wherein defining the model of the network ...

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Номер записи: 75
25-08-2022 дата публикации

NEUROSTIMULATION USING TIME-INTERLEAVED CASCADE OF BIPOLAR ELECTRODE COMBINATIONS

Номер: US20220266029A1
Автор: Cleland Andrew J., Kramer Jeffery M., Litvak Leonid M.
Принадлежит:

An example method of delivering electrical stimulation includes obtaining, by an implantable medical device (IMD) connected to a lead carrying a plurality of electrodes, one or more stimulation parameters; and delivering, by the IMD and based on the one or more stimulation parameters, electrical stimulation therapy via the plurality of electrodes, wherein delivering the electrical stimulation therapy comprises scanning delivery of the electrical stimulation therapy through different pairs of electrodes of the plurality of electrodes. 1. A method of delivering electrical stimulation , the method comprising:obtaining, by an implantable medical device (IMD) connected to a lead carrying a plurality of electrodes, one or more stimulation parameters; anddelivering, by the IMD and based on the one or more stimulation parameters, electrical stimulation therapy via the plurality of electrodes, wherein delivering the electrical stimulation therapy comprises scanning delivery of the electrical stimulation therapy through different pairs of electrodes of the plurality of electrodes.2. The method of claim 1 , wherein scanning delivery of the electrical stimulation therapy through the different pairs of electrodes comprises:delivering, at a first time, bipolar electrical stimulation via a first pair of electrodes of the plurality of electrodes; anddelivering, at a second time that is different than the first time, bipolar electrical stimulation via a second pair of electrodes of the plurality of electrodes, different from the first pair of electrodes.3. The method of claim 2 , further comprising:delivering, at a third time that is different than the first time and the second time, bipolar electrical stimulation via a third pair of electrodes of the plurality of electrodes, different from the first and second pairs of electrodes.4. The method of claim 2 , wherein the second pair of electrodes includes an electrode that is included in the first pair of electrodes and an electrode ...

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Номер записи: 76
27-05-2021 дата публикации

Neuromodulation system

Номер: US20210153942A1
Автор: Edoardo Paoles, Jeroen Tol, Jurriaan Bakker, Mathieu Scheltienne
Принадлежит: GTX Medical BV

Neuromodulation systems and corresponding methods for providing neuromodulation are disclosed. The neuromodulation systems can include at least one input module for inputting patient data into the neuromodulation system. The systems can further include at least one model calculation and building module for building a patient model, the patient model describing the anatomy and/or physiology and/or pathophysiology and the real and/or simulated reaction of the patient on a provided and/or simulated neuromodulation. The systems can further include at least one computation means for using the patient model (M) and calculating the impact of the provided and/or simulated neuromodulation.

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Номер записи: 77
02-05-2019 дата публикации

System for improving neurostimulation compliance

Номер: US20190126039A1
Автор: Michael Sasha John, Paul B. Yoo
Принадлежит: EBT Medical Inc

Nerve stimulation systems and methods are disclosed for providing improved compliance of a patient to a therapy regimen. Patient compliance is assessed and notification or treatment events can be scheduled, rescheduled or otherwise adjusted based upon patient compliance or non-compliance according to compliance rules and parameters of a treatment compliance module. Both compliance and non-compliance may lead to adjustment of the treatment regimen, scheduled treatment events, and notifications. Gamification of the treatment regimen allows users to obtain points that may be used to receive virtual awards, status awards, or monetary compensation of various forms. Monitoring of usage and compliance can be managed both locally and remotely from the user. Stimulation treatment, compliance monitoring, and gamification is disclosed for treatments using external or implanted stimulators, or the combination.

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Номер записи: 78
01-09-2022 дата публикации

HIGH DUTY CYCLE ELECTRICAL STIMULATION THERAPY

Номер: US20220273949A1
Автор: Johanek Lisa M.
Принадлежит:

In some examples, a medical device is configured to deliver high dose electrical stimulation therapy to a patient by at least generating and delivering an electrical stimulation signal having a relatively high duty cycle, and a stimulation intensity less than a perception or paresthesia threshold intensity level for the patient. The pulses of the electrical stimulation signal may each have a relatively low amplitude, but due at least in part to a relatively high number of pulses per unit of time, a dose of the electrical stimulation may be high enough to elicit a therapeutic response from the patient. 1. A method comprising:determining a paresthesia or perception threshold for a patient;determining, for a selected frequency of an electrical stimulation signal, a strength-duration curve based on the paresthesia or perception threshold; anddetermining, by processing circuitry and based on the strength-duration curve, a set of one or more electrical stimulation parameter values for generating the electrical stimulation signal having stimulation intensity less than at least one of the perception threshold or the paresthesia threshold of the patient, and having a duty cycle in a range of about 5% to about 50%, a frequency in a range of about 1 Hertz to about 1400 Hertz, and a pulse width in a range of about 0.1 millisecond to about 5 milliseconds.2. The method of claim 1 , wherein the frequency is in a range of about 1 Hertz to about 1000 Hertz.3. The method of claim 1 , wherein the pulse width is in a range of about 0.1 millisecond to about 1 millisecond.4. The method of claim 1 , wherein the duty cycle is in a range of about 10% to about 40%.5. The method of claim 1 , wherein the duty cycle is an on-time of the pulses per second.6. The method of claim 1 , wherein determining the set of one or more electrical stimulation parameter values comprises determining a plurality of therapy programs each including a respective electrode combination claim 1 , the method further ...

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Номер записи: 79
03-06-2021 дата публикации

THERAPY PARAMETER SELECTION BASED ON ECAP FEEDBACK

Номер: US20210162215A1
Автор: Torgerson Nathan A.
Принадлежит:

Techniques for therapy delivery are described. A processing circuit may adjust a first therapy parameter from a first level to a second level, and responsive to the adjustment of the first therapy parameter, compare a level of an evoked compound action potential (ECAP) generated from therapy delivery based on the adjusted first therapy parameter to an ECAP threshold. The processing circuit may adjust a second therapy parameter from a third level to a fourth level based on the comparison. The second therapy parameter is different than the first therapy parameter. The processing circuit may cause therapy delivery with the first therapy parameter at the second level and the second therapy parameter at the fourth level. 1. A method of therapy delivery , the method comprising:determining that a patient is likely to or is experiencing therapy accommodation;adjusting a first therapy parameter from a first level to a second level different than the first level based on the determination that the patient is to or is experiencing therapy accommodation;responsive to the adjustment of the first therapy parameter, comparing a level of an evoked compound action potential (ECAP) generated in response to therapy delivered with the adjusted first therapy parameter to an ECAP threshold;adjusting a second therapy parameter from a third level to a fourth level different than the third level based on the comparison, wherein the second therapy parameter is different than the first therapy parameter; andcausing delivery of the therapy with the first therapy parameter at the second level and the second therapy parameter at the fourth level.2. The method of claim 1 , wherein determining that the patient is to or is experiencing therapy accommodation comprises determining that there is a likelihood of therapy accommodation.3. The method of claim 1 , wherein determining that the patient is to or is experiencing therapy accommodation comprises determining that a set amount of time has elapsed. ...

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Номер записи: 80
17-05-2018 дата публикации

IMPLANT AND DELIVERY SYSTEM FOR NEURAL STIMULATOR

Номер: US20180132947A1
Автор: Dayan Avinoam, Dvorsky Israel, Shai Eyal
Принадлежит:

An apparatus is provided including an implantable neural stimulator which is advanced through a greater palatine canal to a sphenopalatine ganglion (SPG) of a subject and has an implant-impedance-sensing electrode. The apparatus further includes an auxiliary impedance-sensing electrode and first and second wires, electrically coupled respectively to the implant-impedance-sensing and auxiliary-impedance-sensing electrodes. Impedance-based navigation circuitry includes a voltage generator configured to apply, current between the implant-impedance-sensing and auxiliary-impedance-sensing electrodes through the wires; an impedance sensor configured to measure an impedance between the implant-impedance-sensing and auxiliary-impedance-sensing electrodes based on the applying of the current; and a disposition tracker configured to determine, based on a change in the measured impedance, a disposition of the implantable neural stimulator in the greater palatine canal. Other applications are also described. 1. An apparatus comprising:an implantable neural stimulator (i) configured to be advanced through a greater palatine canal to a sphenopalatine ganglion (SPG) of a subject and (ii) comprising an implant-impedance-sensing electrode;an auxiliary-impedance-sensing electrode;first and second wires, electrically coupled respectively to the implant-impedance- sensing and auxiliary-impedance-sensing electrodes; and a voltage generator configured to apply current between the implant-impedance-sensing and auxiliary-impedance-sensing electrodes through the wires;', 'an impedance sensor configured to measure an impedance between the implant-impedance-sensing and auxiliary-impedance-sensing electrodes based on the applying of the current; and', 'a disposition tracker configured to determine, based on a change in the measured impedance, a disposition of the implantable neural stimulator in the greater palatine canal., 'impedance-based navigation circuitry comprising23-. (canceled)4. The ...

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Номер записи: 81
17-05-2018 дата публикации

METHOD FOR TREATING A PATIENT HAVING A PELVIC FLOOR DYSFUNCTION OR OVERACTIVE BLADDER DISORDER

Номер: US20180133473A1
Автор: John Michael Sasha, YOO PAUL B.
Принадлежит:

A method to treat a patient having a pelvic floor dysfunction or overactive bladder disorder by establishing a neurostimulator having a processor and an electrical signal generator to generate a stimulation signal. The processor is set to one or more parameters effective in the treating of the patient's pelvic disorder or dysfunction including overactive bladder disorder when the stimulation signal is applied to a saphenous nerve of the patient. The neurostimulator is configured to provide the stimulation signal to a stimulator in accordance with a stimulation protocol. At least one stimulator is positioned next to a portion of the saphenous nerve of at least one lower limb of a patient. The processor is operationally activated to provide the stimulation signal to the stimulator for treatment of the patient. 1. A method for treating a patient having a pelvic floor dysfunction or overactive bladder disorder including:establishing at least a first neurostimulator having a processor and an electrical signal generator for generating at least a first stimulation signal in accordance with a stimulation protocol;configuring said processor to set at least one of a plurality of stimulation parameters of a stimulation protocol, with parameter values effective in treating at least one symptom of a patient's pelvic floor dysfunction or overactive bladder disorder when said at least first stimulation signal is applied to a saphenous nerve of a patient;configuring said at least first neurostimulator to provide said at least first stimulation signal to at least a first stimulator in accordance with said stimulation protocol;positioning said at least first stimulator adjacent to a portion of a saphenous nerve of the patient for stimulating the saphenous nerve;operationally activating said processor coupled to said electrical signal generator according to said stimulation protocol to provide said at least first stimulation signal; and,applying said at least first stimulation signal ...

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Номер записи: 82
17-05-2018 дата публикации

Active closed-loop medical system

Номер: US20180133481A1
Автор: Bert BAKKER, Gregoire Courtine, Joachim Von Zitzewitz, Vincent DELATTRE
Принадлежит: G Therapeutics BV

The present disclosure relates to an active closed-loop medical system comprising at least one implantable medical device, at least one non-implanted component and at least a controller for controlling the implantable medical device, wherein the implantable medical device, the non-implanted component and the controller are connected for data exchange, wherein the implantable medical device, the non-implanted component and the controller forming in the active state a closed-loop system in such that the implantable medical device is controlled by the controller on the basis of the signals exchanged with the non-implanted component.

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Номер записи: 83
09-06-2016 дата публикации

Devices for Delivering Non-Invasive Neuromodulation to a Patient

Номер: US20160158534A1
Автор: Fisk Justin, Guarraia Mark, Morang Jeffrey C., Muratori Adam, Petrie Aidan, Wallace Jeffrey M.
Принадлежит:

A mouthpiece for providing non-invasive neuromodulation to a patient. The mouthpiece includes an elongated housing having a center of gravity located within a posterior region, a positioning pad attached to the top surface of the elongated housing for minimizing contact between a patient's upper teeth and the exterior top surface of the elongated housing, and a printed circuit board mounted to a bottom portion of the elongated housing, the printed circuit board having a plurality of electrodes for delivering subcutaneous local electrical stimulation to the patient's tongue. In some embodiments, the mouthpiece includes at least one locator disposed along the anterior region of the elongated housing for contacting a patient's teeth to securely position the mouthpiece within the patient's mouth. 1. A mouthpiece for providing non-invasive neuromodulation to a patient , the mouthpiece comprising:an elongated housing having an anterior region and a posterior region, the elongated housing having a non-planar exterior top surface;a positioning pad, having an anterior and a posterior region, the positioning pad attached to the top surface of the housing for minimizing contact between a patient's upper teeth and the exterior top surface of the elongated housing;a first locator disposed along the anterior region of the elongated housing integral with the top surface, the first locator contacting a patient's upper teeth to securely position the mouthpiece within the patient's mouth; anda printed circuit board mounted to a bottom portion of the elongated housing, the printed circuit board having a plurality of electrodes for delivering subcutaneous local electrical stimulation to the patient's tongue.2. The mouthpiece of wherein the locator comprises an inverted trench claim 1 , a trench claim 1 , or a step.3. The mouthpiece of further comprising a second locator traversing an anterior region of the printed circuit board claim 1 , the second locator mechanically coupling to a ...

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Номер записи: 84
09-06-2016 дата публикации

Methods of Manufacturing Devices for the Neurorehabilitation of a Patient

Номер: US20160158535A1
Автор: David-Hegerich Faith, Fisk Justin, Gordon Joseph M., Guarraia Mark, Muratori Adam, Petrie Aidan, Siwinski Shane, Wallace Jeffrey M.
Принадлежит:

A mouthpiece for providing non-invasive neuromodulation to a patient, the mouthpiece including an elongated housing having an anterior region and a posterior region, the elongated housing having a non-planar exterior top surface and internal structural members disposed within the housing, the internal structural members elastically responding to biting forces generated by the patient, a spacer attached to the top surface of the housing for limiting contact between a patient's upper teeth and the exterior top surface of the elongated housing, and a printed circuit board mounted to a bottom portion of the elongated housing, the printed circuit board having a plurality of electrodes for delivering subcutaneous local electrical stimulation to the patient's tongue. 1. A mouthpiece for providing non-invasive neuromodulation to a patient , the mouthpiece comprising:an elongated housing having an anterior region and a posterior region, the elongated housing having (i) a non-planar exterior top surface and (ii) an interpenetrating network of ribs disposed within the housing, at least some of the ribs aligned parallel to a longitudinal axis of the elongate housing and at least some of the ribs aligned perpendicular to a longitudinal axis of the elongated housing the interpenetrating network of ribs forming pockets in a posterior region of the elongated housing and elastically responding to biting forces generated by the patient;a spacer attached to the top surface of the housing for limiting contact between a patient's upper teeth and the exterior top surface of the elongated housing; anda printed circuit board mounted to a bottom portion of the elongated housing, the printed circuit board having a plurality of electrodes for delivering subcutaneous local electrical stimulation to the patient's tongue.2. The mouthpiece of further comprising ribs aligned parallel to a longitudinal axis of the elongated housing.3. The mouthpiece of further comprising ribs aligned perpendicular ...

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Номер записи: 85
09-06-2016 дата публикации

Methods of Manufacturing Devices for the Neurorehabilitation of a Patient

Номер: US20160158536A1
Автор: Fearis Paul, Fisk Justin, Gordon Joseph M., Muratori Adam, Siwinski Shane
Принадлежит:

A mouthpiece for providing non-invasive neuromodulation to a patient, the mouthpiece including an elongated housing having an anterior region and a posterior region, the elongated housing having a non-planar exterior top surface and internal structural members disposed within the housing, the internal structural members elastically responding to biting forces generated by the patient, a spacer attached to the top surface of the housing for limiting contact between a patient's upper teeth and the exterior top surface of the elongated housing, and a printed circuit board mounted to a bottom portion of the elongated housing, the printed circuit board having a plurality of electrodes for delivering subcutaneous local electrical stimulation to the patient's tongue. 1. A mouthpiece for providing non-invasive neuromodulation to a patient , the mouthpiece comprising:an elongated housing having an anterior region and a posterior region, the elongated housing having a non-planar exterior top surface;a spacer attached to the top surface of the housing for minimizing contact between a patient's upper teeth and the exterior top surface of the elongated housing;a first printed circuit board mounted to a bottom portion of the elongated housing, the first printed circuit board having a plurality of electrodes for delivering subcutaneous local electrical stimulation to the patient's tongue;a rim extending from a bottom portion of the elongated housing, the rim being concentric with a perimeter of the first printed circuit board and surrounding the perimeter of the first printed circuit board and having a u-shaped cross section; anda first well shaped to accommodate an adhesive, the adhesive bonding the first printed circuit board to the elongate housing.2. The mouthpiece of wherein a portion of the rim rests below the first printed circuit board and is configured to prevent a patient's teeth from contacting the printed circuit board.3. The mouthpiece of wherein the first printed ...

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Номер записи: 86
07-06-2018 дата публикации

Devices and Methods for Stimulating Nerves

Номер: US20180154143A1
Автор: Alexandra Haessler, Bruo Strul
Принадлежит: Fempulse LLC

A device positioned in the vagina includes a sensor. The sensor data is used to determine whether a condition is met or exists to trigger a therapeutic response by the device. A device for stimulating nerves adjacent the vagina includes a nerve stimulating element coupled to a main body. The nerve stimulating element is positioned and designed to stimulate the vesical, Frankenhauser's and/or inferior hypogastric plexuses. The device may reside in the vaginal fornices. An implant is also provided which has a nerve stimulating element in contact with a uterosacral ligament. The device positioned in the vagina may be used to charge a power source for an implant, which may be a capacitor.

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Номер записи: 87
07-06-2018 дата публикации

HIGH FREQUENCY NEUROSTIMULATION FOR PELVIC SYMPTOM CONTROL

Номер: US20180154144A1
Автор: Brink Thaddeus S., Dinsmoor David A., Hedstrom Blake A., Nelson Dwight E., Peterson Erik J., Su Xin, Zirpel Lance
Принадлежит:

In general, techniques, methods, systems, and devices for delivering high frequency neurostimulation to control one or more pelvic disorders are described. In one example, a method includes identifying, by a medical device configured to be at least partially implanted in a patient, an indication to inhibit bladder activity. The medical device generates, in response to identifying the indication, electrical stimulation therapy comprising first electrical stimulation pulses comprising a first frequency greater than or equal to about 500 Hertz and less than or equal to about 5,000 Hertz. Further, the medical device delivers the electrical stimulation therapy to a target nerve selected from a group consisting of: a sacral nerve, a pelvic nerve, a tibial nerve, and a pudendal nerve of the patient. 1. A method for delivering electrical stimulation with a medical device configured to be at least partially implanted in a patient , the method comprising:identifying, by the medical device, an indication to inhibit bladder activity;generating, by the medical device and in response to identifying the indication, electrical stimulation therapy comprising first electrical stimulation pulses comprising a first frequency greater than or equal to about 1,000 Hertz and less than or equal to about 5,000 Hertz; anddelivering, by the medical device, the electrical stimulation therapy to a target nerve selected from a group consisting of: a sacral nerve, a pelvic nerve, a tibial nerve, and a pudendal nerve of the patient.2. (canceled)3. The method of claim 1 , wherein the electrical stimulation therapy further comprises second electrical stimulation pulses comprising a second frequency greater than or equal to about 1 Hertz and less than or equal to about 50 Hertz claim 1 , wherein the second electrical stimulation pulses are interleaved with the first electrical stimulation pulses.4. The method of claim 3 , wherein identifying the indication comprises detecting claim 3 , via one or more ...

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Номер записи: 88
23-05-2019 дата публикации

Traumatic brain injury catheter

Номер: US20190150840A1
Автор: Andrew Grande, David Darrow, Samuel Cramer, Sean Lester Moen
Принадлежит: Andrew Grande, David Darrow, Samuel Cramer, Sean Lester Moen

An extraventricular drain system can include a catheter. The catheter can have a shaft including a proximal end and a distal end, a lumen extended along a length of the catheter, and a drain located on the shaft. The drain can be fluidly coupled with the lumen. In an example, an electrode can be located along the shaft at an axial location. A reference contact can be located on the shaft at an axial location further from the distal end than the electrode. The electrode and the reference contact can be configured for electrical communication with a processing unit. In a further example, a first pressure port and a second pressure port can be located at the distal end and have different respective axial locations and respective radial locations. The first and second pressure ports can be in fluid communication with a first and second pressure sensors respectively.

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Номер записи: 89
08-06-2017 дата публикации

DEVICES, SYSTEMS, AND METHODS FOR TREATING OBSTETRIC AND GYNECOLOGICAL DISORDERS

Номер: US20170157397A1
Автор: Funai Edmund, Lockwood Charles, Rezai Ali R.
Принадлежит:

One aspect of the present disclosure relates to a therapy delivery device for treating an obstetric or gynecological disorder other than urinary incontinence in a subject. The therapy delivery device can include a housing, at least one electrode, and a power source. The housing can be configured for implantation in a reproductive system of the subject. The at least one electrode can be connected to the housing and be configured to deliver an electrical signal to an autonomic nervous system nerve target. The power source can be in electrical communication with the at least one electrode. 125-. (canceled)26. A therapy delivery system for treating an obstetric or gynecological disorder other than urinary incontinence in a subject , the therapy delivery system comprising:a housing configured for transvaginal, transcervical, transabdominal stimulation, or transpelvic placement on a subject's skin;at least one electrode connected to the housing and configured to deliver an electrical signal to an autonomic nervous system (ANS) nerve target; anda controller programmed to direct delivery of the electrical signal to the at least one electrode to modulate activity at the ANS nerve target site to treat the obstetric or gynecological disorder.27. The therapy delivery system of claim 26 , wherein the housing is configured for transcutaneous placement on a uterus claim 26 , a vagina claim 26 , an ovary claim 26 , a fallopian tube claim 26 , or a cervix of the subject.28. The therapy delivery system of claim 26 , wherein the controller is programmed to delivery an electrical signal having a frequency of about 1000 Hz or greater.29. The therapy delivery system of claim 26 , wherein the ANS nerve target is a parasympathetic nerve.30. The therapy delivery system of claim 29 , wherein the parasympathetic nerve is a pelvic splanchnic nerve.31. The therapy delivery system of claim 26 , wherein the ANS nerve target is sympathetic nerve.32. The therapy delivery system of claim 31 , ...

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Номер записи: 90
18-06-2015 дата публикации

ONSET-MITIGATING HIGH-FREQUENCY NERVE BLOCK

Номер: US20150165210A1
Автор: BHADRA Niloy, Kilgore Kevin L.
Принадлежит:

A method of blocking signal transmission through a nerve with reduced onset activity includes applying an HFAC to an axon of a nerve to block the transmission of signals through the axon. The method may also include applying a direct current (DC) to the axon, increasing the amplitude of the DC over time to a predetermined amplitude, applying the HFAC, and then decreasing the DC. The method may also include temporarily reducing the amplitude of the HFAC to permit the transmission of signals through the axon and subsequently increasing the amplitude to block transmission without triggering an onset response. The method may also include temporarily applying an unbalanced charge to the nerve and then balancing the charge over time. 138.-. (canceled)39. An apparatus , comprising:an electrode;a waveform generator connected to the electrode; anda controller configured to:control the waveform generator to first apply a first high frequency alternating current (HFAC) to a nerve through the electrode, the first HFAC having a first amplitude and a first frequency, the combination of the first amplitude and the first frequency being configured to produce a conduction block in the nerve, where the conduction block blocks transmission of signals through the nerve;control the waveform generator to then apply a second HFAC to the nerve, the second HFAC having a second amplitude and a second frequency, the combination of the second amplitude and the second frequency being configured to not produce a nerve conduction block in the nerve, the combination of the second amplitude and the second frequency being configured to prevent the occurrence of an onset condition in the nerve upon the application of a third HFAC sufficient to produce a conduction block in the nerve; andcontrol the waveform generator to then apply the third HFAC to the nerve, the third HFAC having a third amplitude and a third frequency, the combination of the third amplitude and the third frequency being configured ...

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Номер записи: 91
18-06-2015 дата публикации

STIMULATION METHOD VIA DEEP-BRAIN STIMULATION

Номер: US20150165239A1
Автор: Mishelevich David J.
Принадлежит:

It is the purpose of this invention to provide methods and systems for non-invasive deep brain neuromodulation using ultrasound for the treatment of anorgasmia, hypo-orgasmia, and for the production of orgasms (Orgasmatron). This can include impacting one or multiple points in a neural circuit to produce Long-Term Potentiation (LTP) or Long-Term Depression (LTD). The ultrasound transducers are attached at fixed positions on a holder. Use of ancillary monitoring or imaging to provide feedback is optional. Control of the ultrasonic transducers includes control of direction of the energy emission, intensity, frequency, and phase/intensity relationships to targeting and accomplishing up-regulation and/or down-regulation. 1. A method of neuromodulating one or a plurality of deep-brain targets using ultrasound stimulation , the method comprising:aiming one or a plurality of ultrasound transducers at one or a plurality of deep-brain targets selected from the group consisting of Temporal Lobe, Nucleus Accumbens, Hypothalamus, Paraventricular Nucleus, and Cerebellum;using a set-up phase imaging with targeting to determine settings of various selected neuromodulation variables;applying one or more non-ultrasound stimulations by selecting and adjusting each in the order of primary stimulations, visual elements, imagining elements, ancillary drug elements, ancillary hormone elements, ancillary secondary stimulations, and ancillary other elements;applying power to each of the ultrasound transducers via a control circuit thereby modulating the activities of the deep brain target regions according to the settings determined during set-up;whereby an orgasm is elicited in response to the ultrasound neuromodulation and non-ultrasound stimulation.2. The method of claim 1 , wherein one or a plurality of primary stimulations is applied to a region selected from the group consisting of external pelvic organ stimulation claim 1 , internal pelvic organ stimulation claim 1 , and other body ...

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Номер записи: 92
24-06-2021 дата публикации

SYSTEM FOR PROVIDING STIMULATION

Номер: US20210187290A1
Автор: CABAN Miroslav, DELATTRE Vincent, ZITZEWITZ Joachim v.
Принадлежит: ONWARD MEDICAL B.V.

Systems and methods are provided for delivering neurostimulation. A system can include at least one stimulation element, the stimulation element being configured to provide stimulation to a least one tendon and/or muscle of a patient. 1. A system for providing neurostimulation , comprising at least one stimulation element , the stimulation element being configured to provide stimulation to a least one of a tendon or a muscle of a patient.2. The system of claim 1 , wherein the system further comprises at least one fixation element to fixate the system close to the at least one of the tendon or the muscle to be stimulated.3. The system of claim 1 , wherein the stimulation element comprises at least one mechanical stimulation element configured to stimulate of the at least one of a tendon or a muscle to be stimulated.4. The system of claim 3 , wherein the mechanical stimulation element comprises at least one of a vibration module claim 3 , a massage module claim 3 , a stretching module claim 3 , or a compression module.5. The system of claim 4 , wherein the mechanical stimulation element is configured to provide mechanical stimulation to the at least one of a tendon or a muscle of a patient claim 4 , the mechanical stimulation at least one of adapted to or synchronous with an exerted muscular activity.6. A method for providing neurostimulation claim 4 , comprising:providing stimulation to a least one of a tendon or a muscle of a patient using at least one stimulation element.7. The method of claim 6 , wherein the patient is a patient with spinal cord injury (SCI).8. The method according to claim 6 , wherein the method further comprises:fixing the stimulation element close to the least one of a tendon or a muscle of the patient to be stimulated before providing the stimulation.9. The method according to claim 6 , wherein the provided stimulation is mechanical stimulation.10. The method according to claim 6 , wherein the provided stimulation is or comprises at least one ...

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Номер записи: 93
04-09-2014 дата публикации

Methods and Systems for Achieving a Physiological Response by Pudendal Nerve Stimulation and Blockade

Номер: US20140249595A1
Автор: Changfeng Tai, Michael B. Chancellor
Принадлежит: University of Pittsburgh

Methods and apparatus are therefore provided herein for stimulating a desired physiological effect. The methods and apparatus can be used to control micturition, defecation and/or ejaculation. The methods and apparatus also can be used to control pain in the lower pelvic region, for example and without limitation, interstitial cystitis. The methods and apparatus also can be used to increase sexual sensation.

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Номер записи: 94
21-05-2020 дата публикации

PARTIAL NERVE CONDUCTION BLOCK USING A SEPARATED INTERFACE NERVE ELECTRODE (SINE)

Номер: US20200155832A1
Автор: Bhadra Narendra, BHADRA Niloy, Kilgore Kevin L., Roberts David, SHAW Laura, VRABEC Tina L.
Принадлежит:

Systems and methods that deliver a continuous partial nerve conduction block are described. A waveform generator can configure one or more direct current (DC) waveforms to provide a continuous partial nerve conduction block. One or more electrodes can deliver the one or more DC waveforms to provide the partial block to the neural structure. Feedback can be provided to the waveform generator related to the partial block. The feedback includes monitoring a property associated with the partial block and altering a parameter associated with the one or more direct current waveforms in response to the property associated with the partial block. 1. A method comprising:configuring, by a waveform generator, one or more direct current waveforms to provide a partial block to a neural structure;delivering the one or more direct current waveforms through one or more electrodes to provide the partial block to the neural structure; monitoring a property associated with the partial block; and', 'altering a parameter associated with the one or more direct current waveforms in response to the property associated with the partial block., 'providing feedback to the waveform generator related to the partial block, wherein the feedback comprises2. The method of claim 1 , wherein the neural structure comprises at least one of tissue related to the central nervous system claim 1 , peripheral nervous system claim 1 , autonomic nervous system claim 1 , and enteric nervous system.3. The method of claim 1 , wherein the one or more electrodes comprise a separated interface nerve electrode (SINE).4. The method of claim 3 , wherein the property associated with the partial block comprises a physiological output controlled by the neural structure produced in response to application the partial block and the parameter associated with the one or more direct current waveforms comprises a current level associated with the one or more direct current waveforms.5. The method of claim 4 , wherein the ...

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Номер записи: 95
21-05-2020 дата публикации

SYSTEMS, METHODS AND KITS FOR PERIPHERAL NERVE STIMULATION

Номер: US20200155844A1
Автор: John Michael Sasha, YOO PAUL B.
Принадлежит:

A neurostimulation system is disclosed for providing treatment to a patient during a therapy session. The neurostimulation system includes a neurostimulator for transmitting magnetic or electrical signals based upon a treatment program. A programmer is connected to the neurostimulator to set a treatment session parameter value to calculate a therapy compliance value. A compliance module is connected to the neurostimulator and the programmer to calculate and store a therapy compliance value. A control module is connected to the compliance module, the programmer and the neurostimulator and determines whether the therapy compliance value is within a range of the treatment program. The neurostimulator transmits electrical or magnetic signals to the patient in a treatment session only if the therapy compliance value meets a compliance criteria. 1. A neurostimulation system for providing treatment to a patient , comprising:at least one neurostimulator configured to transmit electrical or magnetic signals to a patient in at least one treatment session in accordance with a predetermined treatment program defining a set of treatment parameter values or treatment parameter value ranges;at least one programmer coupled to said at least one neurostimulator configured to set a treatment session parameter value for calculating a therapy compliance value based upon said set of treatment parameter values or said treatment parameter value ranges;a compliance module coupled to said at least one neurostimulator and said at least one programmer for calculating and storing said therapy compliance value and said set of treatment parameter values or treatment parameter value ranges; and,at least one control module coupled to said compliance module, said programmer and said neurostimulator, said at least one control module having a processor configured to determine whether said therapy compliance value is within the range of said predetermined program set of treatment parameter values or ...

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Номер записи: 96
14-06-2018 дата публикации

Systems and methods for enhancing or affecting neural stimulation efficiency and/of efficacy

Номер: US20180167482A1
Автор: Allen Wyler, Brad Fowler, Bradford Evan Gliner, Kent Leyde, Leif R. Sloan, Richard Kuntz, W. Douglas Sheffield
Принадлежит: Advanced Neuromodulation Systems Inc

Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy are disclosed. In one embodiment, a system and/or method may apply electromagnetic stimulation to a patient's nervous system over a first time domain according to a first set of stimulation parameters, and over a second time domain according to a second set of stimulation parameters. The first and second time domains may be sequential, simultaneous, or nested. Stimulation parameters may vary in accordance with one or more types of duty cycle, amplitude, pulse repetition frequency, pulse width, spatiotemporal, and/or polarity variations. Stimulation may be applied at subthreshold, threshold, and/or suprathreshold levels in one or more periodic, aperiodic (e.g., chaotic), and/or pseudo-random manners. In some embodiments stimulation may comprise a burst pattern having an interburst frequency corresponding to an intrinsic brainwave frequency, and regular and/or varying intraburst stimulation parameters. Stimulation signals providing reduced power consumption with at least adequate symptomatic relief may be applied prior to moderate or significant power source depletion.

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Номер записи: 97
11-09-2014 дата публикации

METHOD AND SYSTEM FOR TREATMENT OF NEUROMOTOR DYSFUNCTION

Номер: US20140257016A1
Автор: Ahmed Zaghloul
Принадлежит:

Effective systems and methods for improving neural communication impairment of a vertebrate being and affecting motor activity of a peripheral body part including a first signal-providing component configured to provide pulsed peripheral stimulation signals at the peripheral body part, a second signal-providing component configured to provide a pulsed motor cortex stimulation signal to a motor cortex area, a substantially DC signal-providing component configured to provide direct current spinal stimulation signal at a neural spinal junction and a controller component configured to control timing of the pulsed peripheral stimulation signals and the pulsed motor cortex stimulation signal.

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Номер записи: 98
22-06-2017 дата публикации

CONDITIONAL ELECTRICAL STIMULATION

Номер: US20170173327A1
Автор: Bonde Eric H., Wei Xuan K.
Принадлежит:

In general, the disclosure describes techniques for providing conditional electrical stimulation to a patient for pelvic health. An implantable medical device (IMD) may adjust the delivery cycle of the electrical stimulation applied to a patient in response to receiving a delivery cycle parameter associated with one or more of the following: a time in a time schedule, a control device output from a control device, and physiological information from a physiological information sensing device. As an example, the IMD may monitor a status of one or more inputs of the IMD and adjust the delivery cycle of the electrical stimulation applied to the patient based on the status of the input(s). 115-. (canceled)16. A system comprising:a therapy delivery circuit configured to apply a plurality of electrical stimulation pulse trains from an electrical stimulation device to a patient; and cause the therapy delivery circuit to apply, according to a first delivery cycle, a first plurality of electrical stimulation pulse trains from an electrical stimulation device to a patient, wherein each electrical stimulation pulse train of the first plurality of electrical stimulation pulse trains comprises a series of pulses, wherein the first delivery cycle of the first plurality of electrical stimulation pulse trains is a first ratio of a first time duration during which the electrical stimulation pulse train of the first plurality of electrical stimulation pulse trains is delivered to a second time duration between successive electrical stimulation pulse trains of the first plurality of electrical stimulation pulse trains;', 'receive at least one of a user input or physiological information from a physiological information sensing device;', 'cause the therapy delivery circuit to apply, according to a second delivery cycle and in response to the at least one of the user input or the physiological information, a second plurality of electrical stimulation pulse trains from the electrical ...

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Номер записи: 99
22-06-2017 дата публикации

PAIRED STIMULATION PULSES BASED ON SENSED COMPOUND ACTION POTENTIAL

Номер: US20170173341A1
Автор: Johanek Lisa M., Torgerson Nathan A., Vera-Portocarrero Louis
Принадлежит:

In some examples, a method may include delivering an electrical stimulation therapy to a patient, the electrical stimulation therapy comprising a first electrical stimulation pulse delivered to the patient via a first electrode and a second electrical stimulation pulse delivered to the patient via a second electrode, wherein the first electrical stimulation pulse and second electrical stimulation pulse are delivered as paired pulses with respect to each other and a combination of the first electrical stimulation pulse and the second electrical stimulation pulse evoke a compound action potential within the patient; sensing the compound action potential evoked by the combination of the first electrical stimulation pulse and the second electrical stimulation pulse; and adjusting one or more parameters of the electrical stimulation therapy based on the sensed compound action potential 12-. (canceled)3. A method for delivering electrical stimulation therapy to a patient , the method comprising:delivering an electrical stimulation therapy to the patient via a medical device, the electrical stimulation therapy comprising a first electrical stimulation pulse delivered to the patient via a first electrode and a second electrical stimulation pulse delivered to the patient via a second electrode, wherein the first electrical stimulation pulse and second electrical stimulation pulse have a same polarity and are delivered as paired pulses with respect to each other such that a first charge of the first electrical stimulation pulse and a second charge of the second stimulation pulse build on each other to generate a combined charge in tissue of the patient, and the combined charge of the first electrical stimulation pulse and the second electrical stimulation pulse evoke a compound action potential within the patient;sensing, at each of a plurality of sensing locations, a respective magnitude of the compound action potential evoked by the combined charge of the first electrical ...

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Номер записи: 100