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Применить Всего найдено 11788. Отображено 200.
20-12-2008 дата публикации

СТЕНТЫ С НАНЕСЕННЫМ ПОКРЫТИЕМ, СОДЕРЖАЩИМ N-{5-[4-(4-МЕТИЛПИПЕРАЗИНОМЕТИЛ)БЕНЗОИЛАМИДО]-2-МЕТИЛФЕНИЛ}-4-(3-ПИРИДИЛ)-2-ПИРИМИДИНАМИН

Номер: RU2341266C2
Принадлежит: НОВАРТИС АГ (CH)

Предложено медицинское устройство, адаптированное для местного применения или введения в полые трубки и содержащее терапевтическую дозу N-{5-[4-(4-метилпиперазинометил)бензоиламидо]-2-метилфенил}-4-(3-пиридил)-2-пиримидинамина или его соли, кристаллической формы с возможностью его высвобождения, его применение для предупреждения или снижения дисфункции, вызванной доступом к сосудам и соответствующий способ лечения (профилактики). В частности, предложен способ лечения или предупреждения рестеноза у больных диабетом. Выявлено, что местное введение N-{5-[4-(4-метилпиперазинометил)бензоиламидо]-2-метилфенил}-4-(3-пиридил)-2-пиримидинамина или его фармацевтически приемлемой соли или кристаллической формы заявленным способом обеспечивает неожиданно высокую стабильность соединения в течение 45 дней по сравнению с его активностью при введении свободной формы. 5 н.п. ф-лы.

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27-05-2016 дата публикации

БИОРАЗРУШАЕМАЯ ЧАСТИЦА, ВЕЩЕСТВО ДЛЯ ВАСКУЛЯРНОЙ ЭМБОЛИЗАЦИИ И СПОСОБ ПОЛУЧЕНИЯ БИОРАЗРУШАЕМЫХ ЧАСТИЦ

Номер: RU2585104C2

Изобретение относится к медицине, а именно к эндоваскулярной хирургии, и раскрывает биоразрушаемую частицу для эмболизации и способ получения стерилизованной биоразрушаемой частицы. Биоразрушаемая частица включает блоксополимер, получаемый путем сополимеризации биоразрушаемого сополимера, образованного из гидроксикарбоновых кислот a1 и a2, гомополимеры которых имеют температуру стеклования не менее 40°C не более -40°C соответственно, водорастворимого полимера, включающего аминогруппу, гидроксильную или карбоксильную группу у каждого из обоих концов указанного водорастворимого полимера, и поливалентного соединения, включающего дикарбоновую кислоту, ее галогенангидрид, кислотные ангидриды или сложный эфир. Способ включает стадию сополимеризации биоразрушаемого сополимера, водорастворимого полимера и поливалентного соединения для получения блоксополимера, стадии грануляции, нанесения покрытия и радиационного облучения вышеуказанной биоразрушаемой частицы. Группа изобретений позволяет получать ...

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18-02-2021 дата публикации

РАСТЯЖИМЫЙ УКРЕПЛЯЮЩИЙ УЗЕЛ ДЛЯ ХИРУРГИЧЕСКОГО СШИВАЮЩЕГО ИНСТРУМЕНТА

Номер: RU2743406C2
Принадлежит: ЭТИКОН ЭлЭлСи (PR)

Группа изобретений обносится к области хирургических сшивающих инструментов. Растяжимый укрепляющий узел, выполненный с возможностью использования с хирургическим сшивающим инструментом, имеющим продольную ось, содержит: укрепляющий элемент, образованный плоской тканью, имеющей первую сторону и вторую сторону, противоположную первой стороне, причем плоская ткань содержит волокна, которые: по существу не выровнены с продольной осью хирургического сшивающего инструмента или по существу выровнены с продольной осью хирургического сшивающего инструмента; и биоабсорбируемый адгезив, причем биоабсорбируемый адгезив нанесен на первую сторону и/или на вторую сторону плоской ткани и выполнен с возможностью прикрепления растяжимого укрепляющего узла к концевому эффектору хирургического сшивающего инструмента. Укрепляющий узел по существу выполнен с возможностью растяжения в одном направлении. Также раскрывается способ использования хирургического сшивающего инструмента для наложения скоб на ткань ...

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10-02-2012 дата публикации

ПОДЛОЖКА С ЭЛЕКТРОНОДОНОРНОЙ ПОВЕРХНОСТЬЮ, СОДЕРЖАЩЕЙ ЧАСТИЦЫ МЕТАЛЛА, ВКЛЮЧАЯ ПАЛЛАДИЙ

Номер: RU2441672C2
Принадлежит: БАКТИГАРД АБ (SE)

Изобретение относится к медицине. Описана подложка, имеющая электронодонорную поверхность, на которой имеются металлические частицы, содержащие палладий и по меньшей мере один металл, выбранный из группы, состоящей из золота, рутения, родия, осмия, иридия и платины, причем количество указанных металлических частиц составляет примерно от 0,001 до 8 мкг/см2. Примерами изделий с подобным покрытием являются контактные линзы, стимуляторы сердца, электроды для стимуляторов сердца, стенты, зубные имплантаты, грыжевые сетки и ячеистые структуры, оборудование для центрифугирования крови, хирургические инструменты и другие. Модифицируют поверхностные свойства подложки, влияющие на ее биосовместимость и антимикробные свойства. 4 н. и 14 з.п. ф-лы, 4 табл.

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31-07-2019 дата публикации

СОПОЛИМЕРЫ ХИТОЗАНА И ПОЛИЭТИЛЕНГЛИКОЛЯ И ИСПОЛЬЗУЮЩИЕ ИХ СПОСОБЫ И УСТРОЙСТВА ДЛЯ ГЕРМЕТИЗАЦИИ ПОДВЕРГНУТЫХ ПУНКЦИИ КРОВЕНОСНЫХ СОСУДОВ

Номер: RU2696139C2

Настоящее изобретение относится к устройству для герметизации сквозных пункционных отверстий в ткани пациента, содержащему герметизирующее средство, имеющее первую секцию, выполненную из лиофилизированного гидрогеля, причем первая секция расширяется при воздействии на нее физиологической текучей среды внутри пункционного отверстия, при этом первая секция содержит гидрогель, содержащий хитозан, связанный с, по меньшей мере, одним полиэтиленгликолевым полимером, причем, при воздействии водной физиологической текучей среды, гидрогель расширяется и герметизирует сквозное пункционное отверстие в ткани, и направляющий катетер, имеющий полость, при этом герметизирующее средство размещено в полости направляющего катетера, при этом устройство имеет меньший диаметр, чем диаметр пункционного отверстия. Также заявлены способ герметизации пункционных отверстий, выполненных в сосуде, имеющих размер отверстия, составляющий 6 или более по французской шкале, с использованием устройства, имеющего меньший ...

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27-10-2007 дата публикации

ПОЛИМЕРНОЕ ПОКРЫТИЕ ДЛЯ МЕДИЦИНСКИХ УСТРОЙСТВ

Номер: RU2308976C2

Описаны покрытия для медицинского устройства, выполненного из металла. Покрытие включает полимеризованное производное алкоксисилана, содержащее функциональные гидроксигруппы или аминогруппы, ковалентно связанное с поверхностью медицинского устройства, лактоновый полимер, ковалентно связанный с функциональными группами полимеризованного производного алкоксисилана посредством in situ полимеризации, сопровождающейся раскрытием цикла, и, по меньшей мере, один слой сложного полиэфира, нанесенный на связанный лактон. Вместе со слоями сложного полиэфира могут быть нанесены биологически активные агенты. Подобные имеющие покрытие поверхности могут применяться в медицинских устройствах, в частности стентах. Покрытие является биосовместимым и обеспечивает длительное высвобождение биологически активных агентов в течение периодов времени, продолжающихся от нескольких недель до нескольких месяцев. 5 н. и 44 з.п. ф-лы, 8 ил., 7 табл.

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28-02-2020 дата публикации

Номер: RU2018119472A3
Автор:
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24-09-2018 дата публикации

Номер: RU2016133621A3
Автор:
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07-03-2018 дата публикации

Номер: RU2016104112A3
Автор:
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30-05-2019 дата публикации

КОМПОЗИЦИИ РАССАСЫВАЮЩИХСЯ ПОЛИМЕРОВ, ВКЛЮЧАЮЩИЕ СМЕСЬ НА ОСНОВЕ СОПОЛИМЕРОВ, ПОЛУЧЕННЫХ ИЗ МОНО- И ДВУХФУНКЦИОНАЛЬНЫХ ИНИЦИАТОРОВ ПОЛИМЕРИЗАЦИИ, ТЕХНОЛОГИЧЕСКИЕ СПОСОБЫ И МЕДИЦИНСКИЕ УСТРОЙСТВА ИЗ ЭТИХ КОМПОЗИЦИЙ

Номер: RU2689982C1
Принадлежит: ЭТИКОН, ИНК. (US)

Группа изобретений относится к области медицины, а именно к вариантам смеси рассасывающихся полимеров, к их применению для получения медицинского устройства и к способам получения медицинских устройств из указанных смесей. Предложенные смеси включают по меньшей мере 50 вес.% первого полимера, такого как полилактид или сополимер лактида/гликолида (в котором 70 мол.% или более лактида и 30 мол.% или менее гликолида), и не более 50 вес.% второго полимера, такого как сополимер п-диоксанона и гликолида (в котором 90-95 мол.% или 90-99 мол.% п-диоксанона и соответственно 5-10 мол.% или 1-10 мол.% гликолида), причем минимальное количество второго полимера в смеси зависит от молярного количества полимеризованного лактида в первом полимере и рассчитывается по формуле «весовой процент сополимера п-диоксанона и гликолида = (215,6212/мольный процент полимеризованного лактида)». В зависимости от варианта смеси первый или второй полимер изготовлен с использованием смеси моно- и дифункционального инициатора ...

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25-09-2019 дата публикации

РАССАСЫВАЮЩИЕСЯ БИМОДАЛЬНЫЕ КОМПОЗИЦИИ, ВКЛЮЧАЮЩИЕ СМЕСЬ ПОЛИМЕРОВ, СПОСОБЫ ИХ ОБРАБОТКИ И ИЗГОТОВЛЕННЫЕ ИЗ НИХ МЕДИЦИНСКИЕ УСТРОЙСТВА

Номер: RU2701146C1
Принадлежит: ЭТИКОН, ИНК. (US)

Группа изобретений относится к области медицины, а именно к вариантам смеси рассасывающихся полимеров, к их применению для изготовления медицинского устройства и к способу получения медицинского устройства путем обработки указанных смесей. Предложенные смеси включают первый полимер – полилактид или сополимер лактида/гликолида (при содержании лактида 70 мол.% или более) и второй полимер – поли(-диоксанон), минимальный весовой процент которого в смеси зависит от молярного количества полимеризованного лактида в первом полимере. В одном из вариантов первый полимер имеет унимодальное распределение молекулярной массы (ММ), а второй полимер – бимодальное распределение ММ. В другом варианте первый полимер имеет бимодальное распределение ММ, а второй полимер – унимодальное или бимодальное распределение ММ. Группа изобретений обеспечивает повышение скорости кристаллизации смеси полимеров, а также улучшение прочности, жесткости и стабильности размеров медицинского устройства. 4 н. и 4 з.п. ф-лы, 11 ...

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27-10-2013 дата публикации

ТКАНЕИНЖЕНЕРНЫЙ СОСУДИСТЫЙ ГРАФТ МАЛОГО ДИАМЕТРА И СПОСОБ ЕГО ИЗГОТОВЛЕНИЯ

Номер: RU2496526C1

Изобретение относится к области медицины и тканевой инженерии, а именно к сердечно-сосудистой хирургии, и может быть использовано при аорто-коронарном шунтировании, а также хирургической реконструкции периферических сосудов. Описан способ изготовления пористой трубчатой матрицы сосудистого графта из биодеградируемого полимера методом двухфазного электроспининга, при этом в стенку матрицы инкорпорированы биологически активные молекулы, стимулирующие процессы регенерации стенки сосуда в организме. Техническим результатом изобретения является создание тканеинженерного сосудистого графта малого диаметра для биоремоделирования поврежденных сосудов in vivo, обладающего высокой проходимостью и долговечностью. 2 н.п. ф-лы, 1 пр.

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03-07-2018 дата публикации

СПОСОБ ЭНДОТЕЛИЗАЦИИ ПРОТЕЗОВ КРОВЕНОСНЫХ СОСУДОВ

Номер: RU2659704C1

Группа изобретений относится медицине, в частности к способу нанесения несплошного покрытия из металла, выбранного из титана, циркония, гафния, ванадия, ниобия или тантала, на внутреннюю и внешнюю поверхность полимерного протеза кровеносного сосуда из полиэтилентерефталата; а также к протезу кровеносного сосуда, содержащему каркас из полиэтилентерефталата с нанесенным несплошным покрытием из металла. Осуществление изобретения позволяет сократить время образования неоинтимы по всей внутренней поверхности протеза кровеносного сосуда за счет технологии нанесения несплошного покрытия на внутреннюю или внешнюю поверхность протеза. 2 н. и 10 з.п. ф-лы, 1 табл., 5 ил.

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27-05-2012 дата публикации

СПОСОБЫ И КОМПОЗИЦИИ, СОДЕРЖАЩИЕ КЛОНИДИН, ПРЕДНАЗНАЧЕННЫЕ ДЛЯ ЛЕЧЕНИЯ ПОСЛЕОПЕРАЦИОННОЙ БОЛИ

Номер: RU2010111358A
Принадлежит:

... 1. Имплантируемая форма депо лекарственного средства, пригодная для ослабления, профилактики или лечения послеоперационных болей у пациента, нуждающегося в подобном лечении, причем имплантируемая форма депо лекарственного средства содержит терапевтически эффективное количество клонидина или его фармацевтически приемлемой соли и полимер, причем депо лекарственного средства является имплантируемым в участок под кожей с целью ослабления, профилактики или лечения послеоперационных болей и причем депо лекарственного средства способно к высвобождению: 1) примерно от 5% примерно до 45% клонидина или его фармацевтически приемлемой соли по отношению к общему количеству клонидина или его фармацевтически приемлемой соли, содержащемуся в депо, в течение первого периода, составляющего до 48 ч; 2) примерно от 55% примерно до 95% клонидина или его фармацевтически приемлемой соли по отношению к общему количеству клонидина или его фармацевтически приемлемой соли, содержащемуся в депо, в течение последующего ...

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27-02-2010 дата публикации

КРИСТАЛЛИЗУЮЩИЕСЯ ПОЛИМЕРЫ С БОКОВОЙ ЦЕПЬЮ ДЛЯ МЕДИЦИНСКИХ ЦЕЛЕЙ

Номер: RU2008133340A
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... 1. Стент, содержащий кристаллизующийся полимер с боковой цепью, при этом стент выбран из группы, состоящей из пластинчатого стента, плетеного стента, саморасширяющегося стента, проволочного стента, деформируемого стента и скользящего и фиксируемого стента. ! 2. Стент по п.1, в котором кристаллизующийся полимер с боковой цепью, по существу, является рентгеноконтрастным. ! 3. Стент по п.1, в котором кристаллизующийся полимер с боковой цепью содержит тяжелые атомы. ! 4. Стент по п.1, в котором кристаллизующийся полимер с боковой цепью, по существу, не содержит тяжелых атомов. ! 5. Стент по п.1, в котором кристаллизующийся полимер с боковой цепью является биосовместимым. ! 6. Стент по п.1, при этом стент представляет собой расширяющийся стент. ! 7. Стент по п.6, в котором, по меньшей мере, часть расширяющегося стента является расширяющейся в зависимости от температуры или расширяющейся под действием тепла. ! 8. Стент по п.7, в котором расширяющаяся под действием тепла часть является расширяющейся ...

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10-03-2009 дата публикации

ВОЛОКОННОАРМИРОВАННЫЙ КОМПОЗИЦИОННЫЙ РАССАСЫВАЮЩИЙСЯ ЭНДОУРЕТРАЛЬНЫЙ СТЕНТ

Номер: RU2007133110A
Принадлежит:

... 1. Рассасывающийся/разлагаемый многокомпонентный немигрирующий эндоуретральный стент, включающий в себя конструкцию, содержащую эластомерную пленку и волоконную армировку, и при этом конструкция имеет по крайней мере один фиксирующий положение конец. 2. Рассасывающийся/разлагаемый многокомпонентный немигрирующий эндоуретральный стент по п.1, в котором волоконная армировка включает в себя однонитевую спираль и вязаную трубку из многонитевой пряжи. 3. Рассасывающийся/разлагаемый многокомпонентный немигрирующий эндоуретральный стент по п.2, в котором противолежащие края прорези содержат выступающее гибкое ушко и могут упруго перекрываться при сдавливании внутри жесткого трубчатого аппликатора с образованием частично свернутой конфигурации, наружный диаметр которой по меньшей мере на 2% меньше диаметра мочеточника пациента, благодаря чему после извлечения из трубчатого аппликатора напряжение в месте установки в мочеточнике устраняется и края прорези упруго расходятся с образованием номинального ...

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20-02-2014 дата публикации

БАКТЕРИЦИДНЫЕ ПОЛИМЕРНЫЕ КОМПОЗИЦИИ И ИХ ИСПОЛЬЗОВАНИЕ

Номер: RU2012134774A
Принадлежит:

... 1. Бактерицидная композиция, содержащая ионный комплекс анионного полиэфира с бактерицидным металлом, причем анионный полиэфир обладает ионообменной емкостью от приблизительно 0,19 мг-экв/г до приблизительно 1,0 мг-экв/г.2. Бактерицидная композиция по п.1, в которой анионный полиэфир имеет среднюю молекулярную массу (Mw) от приблизительно 2 000 до приблизительно 7 200 дальтон.3. Бактерицидная композиция по п.1, содержащая от приблизительно 20 000 миллионных долей до приблизительно 96 000 миллионных долей вес. бактерицидного металла.4. Бактерицидная композиция по п.1, в которой анионный полиэфир получен путем полимеризации с раскрытием цикла мономеров алифатических лактонов в присутствии металлоорганического катализатора и инициатора анионной полимеризации.5. Бактерицидная композиция по п.4, в которой мономер алифатических лактонов выбран из группы, состоящей из гликолида, триметиленкарбоната, L-лактида, D-лактида, DL-лактида, мезолактида, ε-капролактона, п-диоксанона, 1,3-диоксан-2-она, ...

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10-06-2015 дата публикации

МНОГОЦЕЛЕВОЙ СОСУДИСТЫЙ ИМПЛАНТ

Номер: RU2551938C1

Изобретение относится к медицине, а именно к многоцелевым сосудистым имплантам, и может быть использовано для улавливания сгустков крови в сосудах или в качестве стента. В сосудистом импланте каркас 1 образован совокупностью непересекающихся между собой продольных элементов 2 из биоразлагаемого материала, концы одной из сторон которых соединены между собой в одной точке, и, по меньше мере, двумя поперечными элементами 4 из биоразлагаемого материала. Поперечные элементы 4 выполнены упругими с возможностью обеспечения контакта, по меньшей мере, центральной части каждого из продольных элементов 2 с внутренней поверхностью полости сосуда, достаточного для самоцентрирования каркаса 1 импланта по сосуду с момента его установки в полость сосуда до момента его полного рассасывания. Концы другой стороны продольных элементов 2 также соединены между собой в одной точке симметрично противоположным концам. Продольные элементы 2 выполнены упругими. Соотношение максимального расстояния между двумя внешними ...

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20-04-2013 дата публикации

ИСКУССТВЕННАЯ ТВЕРДАЯ МОЗГОВАЯ ОБОЛОЧКА И СПОСОБ ЕЕ ПРОИЗВОДСТВА

Номер: RU2011140225A
Принадлежит:

... 1. Искусственная твердая мозговая оболочка, изготовленная из электропряденых слоев при помощи технологии электропрядения, при этом вышеупомянутый электропряденый слой состоит, по крайней мере, из гидрофобного электропряденого слоя.2. Оболочка по п.1, отличающаяся тем, что вышеупомянутый гидрофобный электропряденый слой изготовлен методом, включающим электропрядение с использованием одного или нескольких гидрофобных полимеров, выбранных из группы, состоящей из гидрофобного алифатического полиэфира, полиэфир-эфирного сополимера, полиортоэфира, полиуретана, полиангидрида, полифосфазена, полиаминокислоты, сополимеров и их смесей.3. Оболочка по п.2, отличающаяся тем, что вышеупомянутый гидрофобный алифатический полиэфир является, по крайней мере, одним веществом, выбранным из группы, состоящей из полимолочной кислоты, полигликолида, поликапролактона и полигидроксибутирата.4. Оболочка по п.2, отличающаяся тем, что вышеупомянутый полиэфир-эфирный сополимер является, по крайней мере, одним веществом ...

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27-01-2015 дата публикации

БИОРАЗЛАГАЕМЫЕ ЧАСТИЦЫ ДЛЯ МЕДИЦИНСКОГО ЛЕЧЕНИЯ И МАТЕРИАЛ ДЛЯ ЭМБОЛИЗАЦИИ СОСУДОВ

Номер: RU2013133353A
Принадлежит:

... 1. Биоразлагаемые частицы для медицинского применения, состоящие из триблок-сополимера типа A1-A2-B, где:каждый из A1 и A2 означает биоразлагаемый блок-сополимер, составленный мономерами, содержащими гликолевую кислоту, молочную кислоту и 6-гидроксикапроновую кислоту, иB означает растворимый в воде блок-полимер.2. Биоразлагаемые частицы для медицинского применения по п.1, которые испытывают нагрузку на сжатие не более чем 0,1 Н (ньютон) и имеют коэффициент эластического восстановления после сжатия не менее чем 80% в состоянии насыщения водой.3. Биоразлагаемые частицы для медицинского применения по п.1 или 2, где в указанном биоразлагаемом блок-сополимере пропорция структуры, полученной из гликолевой кислоты, составляет от 10 до 30%.4. Биоразлагаемые частицы для медицинского применения по п.1 или 2, где в указанном биоразлагаемом блок-сополимере пропорция структуры, полученной из молочной кислоты относительно структуры, полученной из гликолевой кислоты, составляет не менее чем 50%.5. Биоразлагаемые ...

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10-10-2011 дата публикации

ОБНАРУЖЕНИЕ ЛАКРИМАЛЬНЫХ ИМПЛАНТАТОВ

Номер: RU2010112417A
Принадлежит:

... 1. Аппарат, включающий лакримальный имплантат, по крайней мере частично вставляемый в слезную точку, причем лакримальный имплантат включает: ! сердцевину имплантата; и ! корпус имплантата, причем корпус имплантата включает полость, выполненную по размеру и форме для вхождения сердцевины имплантата, ! при этом сердцевина имплантата и/или полость имплантата включает обнаруживаемое устройство, приспособленное для обеспечения автоматического обнаружения лакримального имплантата отдельным обнаруживающим устройством. ! 2. Аппарат по п.1, в котором обнаруживаемое устройство включает чип радиочастотной идентификации (РЧИ), приспособленный для передачи обнаруживаемого сигнала на обнаруживающее устройство. ! 3. Аппарат по п.1, в котором обнаруживаемое устройство включает люминесцентный материал, приспособленный для отражения света к обнаруживающему устройству. ! 4. Аппарат по п.3, в котором люминесцентный материал включает квантовую точку. ! 5. Аппарат по п.1, в котором обнаруживаемое устройство ...

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10-07-2016 дата публикации

ИМПЛАНТИРУЕМОЕ УРОЛОГИЧЕСКОЕ УСТРОЙСТВО С УЛУЧШЕННОЙ ХАРАКТЕРИСТИКОЙ ИЗВЛЕЧЕНИЯ

Номер: RU2014148165A
Принадлежит:

... 1. Медицинское устройство, содержащее:урологическое устройство; ипо меньшей мере одну нить для извлечения, прикрепленную к урологическому устройству, имеющую проксимальный конец, соединенный с урологическим устройством и противоположный дистальный конец,при том, что нить для извлечения выполнена в начальной ограниченной форме, которая, после выбранного времени установки медицинского устройства в мочевом пузыре пациента, изменяется и принимает свободную форму, в которой дистальный конец по меньшей мере одной нити для извлечения выступает в мочеиспускательный канал из мочевого пузыря, в связи с этим устройство обеспечивает контролируемый выход дистального конца нити для извлечения из мочеиспускательного канала с возможностью позволить извлечение медицинского устройства из мочевого пузыря, потянув при этом за нить для извлечения.2. Медицинское устройство по п. 1, дополнительно содержащее по меньшей мере один биоразлагаемый компонент, выполненный с возможностью (i) поддерживать по меньшей мере ...

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28-11-2002 дата публикации

GEFÄSSSTENT UND ZUGEHÖRIGE EINFÜHRUNGSVORRICHTUNG

Номер: DE0069331967T2
Автор: IGAKI KEIJI, IGAKI, KEIJI

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24-10-2019 дата публикации

PORÖSES POLYESTERMATERIAL

Номер: DE112018000261T5

Ein Polymermaterial, das eine thermoplastische Zusammensetzung beinhaltet, die eine kontinuierliche Phase enthält, die einen Polyester und ein Copolyetherester-Elastomer beinhaltet, wird bereitgestellt. Das Copolyetherester-Elastomer ist in der kontinuierlichen Phase in der Form diskreter Bereiche verteilt. Ein poröses Netzwerk ist in der thermoplastischen Zusammensetzung definiert, das eine Vielzahl von Nanoporen beinhaltet.

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09-06-2004 дата публикации

Chirurgisches Implantat

Номер: DE0010254215A1
Принадлежит:

Ein chirurgisches Implantat hat eine Grundstruktur mit einer zumindest teilweisen Beschichtung. Das Implantat weist alpha-Hydroxycarbonsäure-Oligomere (vorzugsweise Milchsäure-Oligomere) auf und/oder lässt diese nach der Implantation als Abbauprodukt entstehen. Die Beschichtung enthält Polyolmonofettsäureester, vorzugsweise Glycerinmonofettsäureester. Das Implantat wirkt antimikrobiell.

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10-07-1986 дата публикации

Номер: DE0003323867C2
Принадлежит: JASCH, HANS-PETER

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22-06-1978 дата публикации

RESORBIERBARES CHIRURGISCHES MATERIAL

Номер: DE0001293396C2
Автор:
Принадлежит:

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02-06-1999 дата публикации

Bio-absorbable segmented copolymer(s) for medical appliances

Номер: DE0019828416A1
Принадлежит:

Bioabsorbable, biocompatible segmented copolymers having a Young's modulus of less than 1.379 GPa (200,000 psi) and comprising: (a) 30-95 mol% of a prepolymer consisting of 5-95 mol% iota -caprolactone units and 5-95 mol% p-dioxanone units; and (b) 5-70 mol% of glycolide units. Independent claims are also included for the following: (1) Preparation process for a segmented polymer involving: (i) polymerisation of p-dioxanone and iota -caprolactone in the presence of a catalyst and an initiator to form a prepolymer; and (ii) copolymerising the prepolymer with 5-70 mol% glycolide. (2) A segmented polymer obtained comprising 10-45 mol% glycolide units and 55-90 mol% p-dioxanone and iota -caprolactone units.

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16-02-2006 дата публикации

BIORESORBIERBARER STENT

Номер: DE0060019922T2
Автор: JADHAV S, JADHAV, S.

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16-08-2000 дата публикации

Bio-compatible polymeric materials

Номер: GB0000015433D0
Автор:
Принадлежит:

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12-01-2000 дата публикации

Biomimetic silicone elastomers

Номер: GB0009926507D0
Автор:
Принадлежит:

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10-08-2011 дата публикации

Polymeric materials

Номер: GB0201110729D0
Автор:
Принадлежит:

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16-12-2015 дата публикации

Implant

Номер: GB0201519451D0
Автор:
Принадлежит:

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14-03-2018 дата публикации

Apparatus

Номер: GB0201801403D0
Автор:
Принадлежит:

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31-10-1984 дата публикации

SURGICAL DEVICE

Номер: GB0008423930D0
Автор:
Принадлежит:

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26-02-1997 дата публикации

Hydrogels

Номер: GB0009700508D0
Автор:
Принадлежит:

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23-04-1997 дата публикации

Hydrogels

Номер: GB0009704288D0
Автор:
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28-02-1990 дата публикации

DRESSINGS

Номер: GB0002222173A
Принадлежит:

A dressing system suitable for use for example as a surgical incise drape comprises a solution of film-forming, skin-adhering first polymer and a second component comprising a non skin-adhering film of a second polymer but which will bond to a film of the first polymer.

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17-05-2017 дата публикации

Implant

Номер: GB0002544266A
Принадлежит:

An implant 1 comprising a surface 32 engageable with a portion of at least one body part, preferably a bone 2, and attachable thereto be means of an adhesive that is preferably cured by means on an external energy source such as EM radiation, ultrasound energy or thermal energy; most preferably UV light. The implant 1 may also be provided with a conduit 4 through which the energy source may be introduced. A flange 30 extending around the periphery of the implant 1 and protruding towards the body is also taught. The flange 30 provides a stand-off between the surface 32 and the body when the implant 1 is in use, thereby controlling the thickness of adhesive in use. Also disclosed is a method of surgery comprising forming an implant 1, applying a layer of adhesive to a surface 32 of the implant 1 and engaging the surface 32 with a body part. It is also disclosed that the implant 1 may be shaped in accordance with data derived from the body part in 3D, preferably obtained using computer tomography ...

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09-02-1983 дата публикации

Annealed polydioxanone surgical device and method for producing the same

Номер: GB0002102827A
Принадлежит:

Annealed surgical devices made from polymers of p-dioxanone and methods for manufacturing the same. The devices have a crystallinity of at least 43% and a density of at least 1.3845 g/cc.

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07-08-1985 дата публикации

SURGICAL FASTENER AND MEANS FOR APPLYING SAME

Номер: GB0002118665B

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20-10-1982 дата публикации

Flexible copolymers and surgical products therefrom

Номер: GB0002096627A
Принадлежит:

Novel flexible polyesters comprising copolymers made from p- hydroxy oxy alkylene benzoate and one of the following sequences: (1) an alkylene 2-alkenyl (or alkyl) succinate; (2) an alkylene dimerate (from the dimer of a long chain unsaturated fatty acid); (3) a dicarboxylate of polyoxytetramethylene glycol, and pliant surgical products, particularly monofilament surgical sutures, therefrom.

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11-05-1983 дата публикации

Polyamide surgical device and method for producing the same

Номер: GB0002108135A
Принадлежит:

Thermally formed aliphatic polyamide surgical devices having an alpha crystallinity of at least 15% and a total crystallinity in excess of 25%, are obtained by heating them at 60 DEG C to 100 DEG C in an environment essentially saturated with moisture (preferably in hot water), to improve their strengths.

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18-07-1984 дата публикации

DEVICE

Номер: GB0008415265D0
Автор:
Принадлежит:

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02-11-1988 дата публикации

POLYURETHANE PLUG & PREPARATION OF MAKING SAME

Номер: GB0008822653D0
Автор:
Принадлежит:

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25-07-2018 дата публикации

Aneurysm treatment apparatus

Номер: GB0002558920A
Принадлежит:

Aneurysm treatment apparatus includes a catheter assembly (10, Fig 1) comprising a catheter 12 with preferably has a steerable distal end (14, Fig 1). A pouch 40 is further disposed over the distal end of the catheter 12 so as to be in co-axial overlying relationship therewith. A constraining sheath 60 may further be disposed over a major portion of the pouch and has a proximal portion 64 which is bonded to the catheter 12 but terminates short of the distal end 26 of the catheter 12, so as to leave a distal end of the pouch 40 exposed. In use, the catheter can be steered into an aneurysm sac (102, Fig 11) and filler material fed through the catheter 12 in order to fill the pouch 40. The pouch 40 will expand from its distal end 44 with filler material and gradually slide off the sheath 12 as it fills the aneurysm sac 102. The sheath 60 prevents the pouch 40 from expanding proximally, and potentially adversely affecting the filling process.

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30-10-2019 дата публикации

Porous polyester material

Номер: GB0002573246A
Принадлежит:

A polymeric material that includes a thermoplastic composition containing a continuous phase that includes a polyester and a copolyetherester elastomer is provided. The copolyetherester elastomer is dispersed within the continuous phase in the form of discrete domains. A porous network is defined within the thermoplastic composition that includes a plurality of nanopores.

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03-01-1996 дата публикации

Bio-degradable/absorbable barrier membrane

Номер: GB0009522025D0
Автор:
Принадлежит:

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11-09-2019 дата публикации

Device for fixing Spine

Номер: GB0201910942D0
Автор:
Принадлежит:

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30-09-2013 дата публикации

low compliance Hemisphere for bladder expansion in patients with

Номер: AP0201307149A0
Автор: SAMBUSSETI ANTONIO
Принадлежит:

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30-09-2013 дата публикации

low compliance Hemisphere for bladder expansion in patients with

Номер: AP2013007149A0
Автор: SAMBUSSETI ANTONIO
Принадлежит:

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14-10-1996 дата публикации

Polymers containing diester units

Номер: OA0000010052A
Принадлежит:

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15-08-2007 дата публикации

CONTAINER IMPLANT

Номер: AT0000368065T
Автор: SHALABY S W, SHALABY, S.W.
Принадлежит:

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15-08-2009 дата публикации

HIGH-STRENGTH BIOABSORBABLE MATERIALS, POLYGLYKOLSÄURE CONTAINING

Номер: AT0000439405T
Автор: ROSE JOHN, ROSE, JOHN
Принадлежит:

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15-12-2009 дата публикации

DRUG OF DELIVERING ENDOVASKULÄRER STENT

Номер: AT0000451075T
Принадлежит:

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15-06-2010 дата публикации

FLEXIBLE ELEMENT FROM A X-RAY-PERMEABLE MATERIAL FOR A MEDIZINALTECHNI DEVICE

Номер: AT0000470460T
Автор: OESCH MARC, OESCH, MARC
Принадлежит:

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15-07-2010 дата публикации

BONE PLATE

Номер: AT0000473702T
Принадлежит:

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15-03-2012 дата публикации

DRILLING CAN FOR USE IN A BONE PLATE

Номер: AT0000547057T
Принадлежит:

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15-02-2012 дата публикации

POLYMER FABRIC SEALING

Номер: AT0000543520T
Принадлежит:

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15-03-2012 дата публикации

PROCEDURE FOR FORMING POLY (1,4-DIOXANON)

Номер: AT0000549143T
Принадлежит:

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15-08-1977 дата публикации

SURGICAL ONE RETRAKTIONSVORRICHTUNG

Номер: AT0000630874A
Автор:
Принадлежит:

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15-05-2011 дата публикации

NON--DEGRADABLE LITTLE POURING WATER-SOLUBLE ROENTGEN DENSITY OF HYDRAULIC GEL

Номер: AT0000508758T
Принадлежит:

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15-04-2016 дата публикации

Vorverbundene mehrschichtige Folie zur Abdeckung einer Knochendefektstelle

Номер: AT515384B1
Принадлежит:

The invention relates to a preliminarily bonded multilayer film (1) for covering a bone defect site (2), in particular in the region of a jaw bone, the film (1) comprising at least one shaping molding layer (3) for molding the film (1) onto the bone defect site (2) and at least one cover layer (4, 4a, 4b) for covering the bone defect site (2), the molding layer (3) and the at least one cover layer (4, 4a, 4b) being substantially completely resorbable.

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15-02-1996 дата публикации

VERNETZUNGSAGENTIEN

Номер: AT0000133158T
Принадлежит:

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15-01-1993 дата публикации

ABSORBABLE BONE PLATE.

Номер: AT0000083909T
Автор: TUNC DEGER, TUNC, DEGER
Принадлежит:

Подробнее
15-12-1992 дата публикации

PROTHETI DEVICES.

Номер: AT0000083157T
Принадлежит:

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05-01-2012 дата публикации

Methods to improve adhesion of polymer coatings over stents

Номер: US20120004721A1
Принадлежит: Individual

Methods are disclosed to improved adhesion of polymer coatings over polymer surfaces of stents which include plasma treatment, applying an adhesion promoting layer, surface treatments with solvents, and mechanical roughening techniques.

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09-02-2012 дата публикации

Intravitreous self adaptive stent

Номер: US20120035738A1
Автор: Rongping Dai
Принадлежит: EMPIRE TECHNOLOGY DEVELOPMENT LLC

Disclosed herein are devices, methods and kits for a stent for treating an eye, comprising a flexible material, wherein the stent is self adaptive to a dimension of a vitreous cavity in the eye.

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08-03-2012 дата публикации

Method of Manufacturing a Polymeric Stent Having Reduced Recoil

Номер: US20120059451A1

Methods of manufacturing polymeric intraluminal stents, and stents made by such methods, are disclosed. The methods provide for manufacturing polymeric intraluminal stents by inducing molecular orientation in the stents by radial compression thereby providing stents with low recoil post-deployment.

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22-03-2012 дата публикации

Reduced profile medical balloon element

Номер: US20120070599A1
Автор: Alan M. Zamore
Принадлежит: Individual

Medical dilatation balloons comprise a polymer that has the attribute of memory, and/or is crosslinked to impart memory. Such balloons exhibit a reduced tendency to overinflate at high inflation pressures. Furthermore, such balloons when shrunk radially by the application of heat while restraining axial shrinkage, exhibit customizable linear or non-linear compliance curves and lower crosslinking profile relative to the same balloon when unshrunk. Also disclosed is an expansive element within a tube whose outer diameter is equal to the outer diameter of the tube from which it was made. In addition, disclosed are (a) processes for preparing crosslinkable polymers, (b) joining crosslinked balloons to catheter systems, (c) forming shrunk balloon elements, and (d) forming an expansive element within a tube whose outer diameter is equal to the outer diameter of the tube from which it was made.

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19-04-2012 дата публикации

Method To Minimize Chain Scission And Monomer Generation In Processing of Poly(L-Lactide) Stent

Номер: US20120091633A1
Принадлежит: Abbott Cardiovascular Systems Inc

Methods of fabricating an implantable medical devices such as stents made from biodegradable polymers are disclosed that reduce or minimize chain scission and monomer generation during processing steps. The method includes processing a poly(L-lactide) resin having an number average molecular weight between 150 to 200 kD in an extruder in a molten state. A poly(L-lactide) tube is formed from the processed resin and a stent is fabricated from the tube. The number average molecular weight of the poly(L-lactide) of the stent after sterilization is 70 to 100 kD.

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17-05-2012 дата публикации

Neurological apparatus

Номер: US20120123391A1
Принадлежит: Renishaw Ireland Ltd

A guide element for insertion into the brain to guide implantable instruments, wherein the guide element comprises an elongate part, the elongate part having a composition of at least 80% tungsten carbide. The guide element may have a coating, such as a biocompatible plastics material which is more resilient than the elongate part.

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31-05-2012 дата публикации

Phosphorylcholine-based amphiphilic silicones for medical applications

Номер: US20120136087A1
Принадлежит: DSM IP ASSETS BV

Amphiphilic biomimetic phosphorylcholine-containing silicone compounds for use in both topical and internal applications as components in biomedical devices. The silicone compounds, which include zwitterionic phosphorylcholine groups, may be polymerizable or non-polymerizable. Specific examples of applications include use as active functional components in ophthalmic lenses, ophthalmic lens care solutions, liquid bandages, wound dressings, and lubricious and anti-thrombogenic coatings.

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14-06-2012 дата публикации

Stent formed from crosslinked bioabsorbable polymer

Номер: US20120149850A1
Автор: Lothar W. Kleiner
Принадлежит: Abbott Cardiovascular Systems Inc

A stent having a stent body made from a crosslinked bioabsorbable polymer is disclosed. A method of making the stent including exposing a tube formed from a bioabsorbable polymer to radiation to crosslink the bioabsorbable polymer and forming a stent body from the exposed tube is disclosed. The tube can include a crosslinking agent which induces crosslinking upon radiation exposure. Additionally or alternatively, the bioabsorbable polymer can be a copolymer that crosslinks upon exposure to radiation in the absence of a crosslinking agent.

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21-06-2012 дата публикации

Surgical Implant

Номер: US20120158136A1
Принадлежит: Synthes USA LLC

A surgical implant comprises a body having a compressed state and an uncompressed state. An envelope contains the body in at least the compressed state. The envelope forms an air-tight seal around the body in the compressed state and is water-soluble or degradable in body fluids.

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12-07-2012 дата публикации

Intraluminal polymeric devices for the treatment of aneurysms

Номер: US20120179193A1

Novel medical devices and uses thereof for lining a blood vessel and/or treating an aneurysm are disclosed herein. The device comprises a non-metallic expandable tubular structure, implantable in a body vessel and being made, at least in part, from a polymeric system characterized by a stiffness which changes upon stimulation under physiological conditions. Novel polymeric systems are further disclosed herein, which are configured to produce a polymeric material upon stimulation under physiological conditions, such that a stiffness of said polymeric material is higher than a stiffness of said system. Uses of polymer systems in the manufacture of a device are further disclosed.

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19-07-2012 дата публикации

Low viscosity liquid polymeric delivery system

Номер: US20120183629A1
Автор: Richard L. Dunn
Принадлежит: DUNN RES AND CONSULTING LLC

Low viscosity biodegradable polymer solutions of a liquid biodegradable polymer and biocompatible solvent and methods of using the compositions to form a biodegradable liquid polymer implant are provided.

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26-07-2012 дата публикации

Biodegradable endoprostheses and methods for their fabrication

Номер: US20120187606A1
Принадлежит: Elixir Medical Corp

Biodegradable endoprostheses are formed from amorphous polymers having desirable biodegradation characteristics. The strength of such amorphous polymers is enhanced by annealing to increase crystallinity without substantially increasing the biodegradation time.

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13-09-2012 дата публикации

Stent fabrication via tubular casting processes

Номер: US20120232643A1
Принадлежит: Amaranth Medical Pte

Tubular casting processes, such as dip-coating, may be used to form substrates from polymeric solutions which may be used to fabricate implantable devices such as stents. The polymeric substrates may have multiple layers which retain the inherent properties of their starting materials and which are sufficiently ductile to prevent brittle fracture. Parameters such as the number of times the mandrel is immersed, the duration of time of each immersion within the solution, as well as the delay time between each immersion or the drying or curing time between dips and withdrawal rates of the mandrel from the solution may each be controlled to result in the desired mechanical characteristics. Additional post-processing may also be utilized to further increase strength of the substrate or to alter its shape.

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04-10-2012 дата публикации

System and Method for Formation of Biodegradable Ultra-Porous Hollow Fibers and Use Thereof

Номер: US20120248658A1
Принадлежит: COVIDIEN LP

A system and method for forming biodegradable ultra-porous hollow fibers are disclosed. The fibers are formed by electrospinning a liquid polymer composition (e.g., solution) of a high molecular weight aliphatic polyester in a controlled environment.

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18-10-2012 дата публикации

In-Situ Forming Foams for Treatment of Aneurysms

Номер: US20120265287A1
Принадлежит: Arsenal Medical Inc

Systems, methods and kits relating to in-situ forming polymer foams for the treatment of aneurysms are disclosed. The systems include an insertable medical device and an in-situ forming foam that is formed from a polymer that reacts in an aqueous environment. When used to treat an aneurysm, the foam is placed into contact with at least a portion of an exterior surface of the medical device and/or the tissue surface of the aneurysm.

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01-11-2012 дата публикации

Soluble coating comprising polyelectrolyte with hydrophobic counterions

Номер: US20120276185A1
Принадлежит: Individual

The present invention provides an implantable device having a biosoluble coating comprising a polyelectrolyte and a counterion and the methods of making and using the same.

Подробнее
08-11-2012 дата публикации

Helical hybrid stent

Номер: US20120283817A1
Автор: Jacob Richter
Принадлежит: Medinol Ltd

An expandable helical stent is provided, wherein the stent may be formed of an amorphous metal alloy or other non-amorphous metal with a securement. The stent is formed from flat or tubular metal in a helical coiled structure which has an undulating pattern. The main stent component may be formed of a single helically coiled component. Alternatively, a plurality of helically coiled ribbons may be used to form a stent heterogeneous in design, material, or other characteristic particular to that stent. The helical tubular structure may be secured with a securement, such as a weld, interlock or a polymer, to maintain the helical coils in a tubular configuration. The helical coils of the main stent component may be spaced apart or nestled to each other to maintain the tubular shape of the helically coiled stent and prevent the polymer layer from sagging at any point between cycles of the coils.

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22-11-2012 дата публикации

Method and device for loading medical appliance with medicaments and/or polymers

Номер: US20120294499A1
Принадлежит: Microport Medical Shanghai Co Ltd

A method and a device for loading a medical appliance with a medicament and/or polymer includes capturing images of a plurality of grooves or holes of the medical appliance using an image capturing device; performing digital image processing on the image of each of the grooves or holes to obtain a pattern of each of the grooves or holes; calculating a central position of the pattern of each of the grooves or holes, and determining a loading position of each of the grooves or holes based on the central position; and adjusting a relative position between a loading device and the medical appliance to align an outlet of the loading device with the loading position of the medical appliance, and loading each of the grooves or holes with the medicament and/or polymer. The method and device can load the medical appliance with the medicament and/or polymer fast and efficiently.

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22-11-2012 дата публикации

Bioabsorbable stent

Номер: US20120296415A1
Принадлежит: Terumo Corp

A bioabsorbable stent has a relatively high radial force and can be placed directly at the lesion without the possibility or reducing the possibility of occluding the lesion again after placement. The bioabsorbable stent is formed from a mixture composed of a bioabsorbable aliphatic polyester and an aromatic compound having one or more aromatic rings.

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21-02-2013 дата публикации

Polysaccharide Based Hydrogels

Номер: US20130045182A1
Принадлежит: Individual

Polysaccharide based hydrogel compositions and methods of making and using the same are provided. The subject polysaccharide based hydrogel compositions are prepared by combining a polysaccharide component with a hydrophilic polymer and a cross-linking agent. Also provided are kits and systems for use in preparing the subject compositions.

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28-02-2013 дата публикации

Triple Balloon Occlusion and Infusion Catheter

Номер: US20130053758A1
Автор: Melina R. Kibbe
Принадлежит: Northwestern University

Disclosed are balloon catheters for forming liquid cast biodegradable arterial stents, typically, the balloon catheters include multiple balloons and multiple ports and include an element for promoting or initiating curing of a polymer solution via polymerization or cross-linking.

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28-03-2013 дата публикации

Polyisobutylene-based polyurethanes

Номер: US20130079487A1
Принадлежит: Individual

An elastomeric polymer, comprising (1) a hard segment in the amount of 10% to 60% by weight of the elastomeric polymer, wherein the hard segment includes a urethane, urea or urethaneurea; and (2) a soft segment in the amount of 40% to 90% by weight of the elastomeric polymer. The soft segment comprises (a) at least 2% by weight of the soft segment of at least one polyether macrodiol, and/or at least one polycarbonate macrodiol; and (b) at least 2% by weight of the soft segment of at least one polyisobutylene macrodiol and/or diamine.

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11-04-2013 дата публикации

Radially expandable polymer prosthesis and method of making same

Номер: US20130090718A1
Принадлежит: Abbott Cardiovascular Systems Inc

Polymeric stents having fracture toughness and resistance to recoil after deployment are disclosed along with methods of manufacturing such stents. Improvements to mechanical characteristics and other improvements may be achieved by having polymer chains within individual stent struts oriented in a direction that is closer to or in line with the axis of the individual stent struts. The struts are connected to each other by hinge elements that are configured to bend during crimping and deployment of the stent. Ring struts form ring structures. A ring structure can have an overall curvilinear length from about 12 mm to about 15 mm.

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06-06-2013 дата публикации

Bioabsorbable device having composite structure for accelerating degradation

Номер: US20130144376A1
Автор: George Landau, Vipul Dave
Принадлежит: Cordis Corp

A medical device has a structure made of a first biodegradable and/or bioabsorbable material and a second biodegradable and/or bioabsorbable material encapsulating a degradation additive incorporated into the first biodegradable and/or bioabsorbable material. The second biodegradable and/or bioabsorbable material has a degradation rate that is faster than the degradation rate of the first biodegradable and/or bioabsorbable material such that the structure experiences a period of accelerated degradation upon release of the degradation additive following sufficient degradation of the second biodegradable and/or bioabsorbable material.

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08-08-2013 дата публикации

Polymeric biomaterials derived from phenolic monomers and their medical uses

Номер: US20130203713A1
Принадлежит: Rutgers State University of New Jersey

The present invention provides new classes of phenol compounds, including those derived from tyrosol and analogues, useful as monomers for preparation of biocompatible polymers, and biocompatible polymers prepared from these monomeric phenol compounds, including novel biodegradable and/or bioresorbable polymers. These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processibility are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic formulations. The invention also provides methods for preparing these monomeric phenol compounds and biocompatible polymers.

Подробнее
15-08-2013 дата публикации

Adhesive structure with stiff protrusions on adhesive surface

Номер: US20130206330A1

A laminate and process of making the laminate is disclosed comprising: a surgical mesh having first and second surfaces; and an adhesive structure having adhesive and non-adhesive surfaces, wherein the non-adhesive surface of the adhesive structure is laminated to at least one of said first and second surfaces of said surgical mesh, and the adhesive surface of said adhesive structure has protrusions extending therefrom comprising a resin having a Young's modulus of greater than 17 MPa, which protrusions are of sufficiently low diameter to promote adhesion by increasing physical attractive forces between the adhesive structure and a target surface, as measured by shear adhesion.

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15-08-2013 дата публикации

Bis-(alpha-amino)-diol-diester-containing poly (ester amide) and poly (ester urethane) compositions and methods of use

Номер: US20130210931A1
Принадлежит: Medivas LLC

The present invention provides biodegradable, biocompatible bis-(α-amino acyl)-diol-diester-containing poly(ester amide) (PEA) and poly(ester urethane) (PEUR) co-polymer compositions with mechanical properties that can be readily tailored by selection of various combinations and proportions of the building blocks of the co-polymers. The compositions are suitable for use in production of drug-releasing biodegradable particles and implantable surgical devices, such as stents and internal fixation devices. The co-polymer compositions, particles and surgical devices biodegrade in vivo by enzymatic action to release bioactive agents in a controlled manner over time as well as biocompatible breakdown products, including one to multiple different amino acids.

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29-08-2013 дата публикации

BIOABSORBABLE POLYMER COMPOSITIONS EXHIBITING ENHANCED CRYSTALLIZATION AND HYDROLYSIS RATES

Номер: US20130225538A1
Принадлежит: ETHICON, INC.

A bimodal bioabsorbable polymer composition. The composition includes a first amount of a bioabsorbable polymer polymerized so as to have a first molecular weight distribution; a second amount of said bioabsorbable polymer polymerized so as to have a second molecular weight distribution having a weight average molecular weight between about 10,000 to about 50,000 Daltons, the weight average molecular weight ratio of said first molecular weight distribution to said second molecular weight distribution is at least about two to one; wherein a substantially homogeneous blend of said first and second amounts of said bioabsorbable polymer is formed in a ratio of between about 50/50 to about 95/5 weight/weight percent. Also disclosed are a medical device, a method of making a medical device and a method of melt blowing a semi-crystalline polymer blend. 1. A bimodal polymer composition , comprising:(a) a first amount of a fully amorphous bioabsorbable polymer having a first hydrolysis rate and a first molecular weight distribution; and(b) a second amount of said fully amorphous bioabsorbable polymer having a second hydrolysis rate and a second molecular weight distribution having a weight average molecular weight between about 10,000 to about 50,000 Daltons, the weight average molecular weight ratio of said first molecular weight distribution to said second molecular weight distribution is at least about two to one;wherein a substantially homogeneous blend of said first and second amounts of said fully amorphous bioabsorbable polymer is formed in a ratio of between about 50/50 to about 95/5 weight/weight percent, said substantially homogeneous blend having a hydrolysis rate greater than each of said first hydrolysis rate and said second hydrolysis rate.2. The bimodal polymer composition of claim 1 , wherein the bioabsorbable polymer is selected from the group consisting of poly(lactide) claim 1 , poly(glycolide) claim 1 , poly(dioxanone) claim 1 , poly(ε-caprolactone) claim ...

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05-09-2013 дата публикации

Biocompatible surfaces and devices incorporating such surfaces

Номер: US20130231733A1
Принадлежит: WL Gore and Associates Inc

The invention is an improved biocompatible surface for a variety of medical purposes. The biocompatible surface employs a unique tight microstructure that demonstrates enhanced cellular response in the body, particularly when placed in contact with blood. As a blood contact surface, the present invention can be beneficially employed in a wide variety of implantable devices and in many other devices and equipment that come in contact with blood.

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17-10-2013 дата публикации

BIODEGRADABLE PARTICLES FOR MEDICAL TREATMENT AND VASCULAR EMBOLIZATION MATERIAL

Номер: US20130273372A1
Принадлежит: Toray Industries, Inc.

Biodegradable particles for medical use and a vascular embolization material have improved flexibility, cause less aggregation among particles, and have improved particle shape-recovering ability after passing through a catheter or the like. The biodegradable particles for medical use are composed of an A1-B-A2 type triblock copolymer, wherein A1 and A2 are each a block of biodegradable copolymer constituted of monomers including glycolic acid, lactic acid and 6-hydroxycaproic acid, and B is a block of water-soluble polymer. 1. Biodegradable particles for medical use composed of an A1-B-A2 type triblock copolymer , wherein:A1 and A2 are each a block of biodegradable copolymer constituted of monomers comprising glycolic acid, lactic acid and 6-hydroxycaproic acid, andB is a block of water-soluble polymer.2. The biodegradable particles according to claim 1 , which have a compressive load of not more than 0.1 N and a compression recovery ratio of not less than 80% in the water-saturated state.3. The biodegradable particles according to claim 1 , wherein in said block of biodegradable copolymer claim 1 , the ratio of the structure originated from glycolic acid is 10 to 30%.4. The biodegradable particles according to claim 1 , wherein in said block of biodegradable copolymer claim 1 , the ratio of the structure originated from lactic acid with respect to a structure originated from glycolic acid is not less than 50%.5. The biodegradable particles according to claim 1 , wherein in said block of biodegradable copolymer claim 1 , the ratio of a structure originated from lactic acid is not more than 65%.6. The biodegradable particles according to claim 1 , wherein in said block of biodegradable copolymer claim 1 , the ratio of a structure originated from 6-hydroxycaproic acid is 25 to 85%.7. The biodegradable particles according to claim 1 , wherein weight-average molecular weight of said triblock copolymer is 3000 to 100000.8. The biodegradable particles according to claim ...

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07-11-2013 дата публикации

MEDICAL DEVICES AND METHODS INCLUDING POLYMERS HAVING BIOLOGICALLY ACTIVE AGENTS THEREIN

Номер: US20130292869A1
Принадлежит:

The implant design is a drug loaded polymer device, such as a rod, designed to control the release of a biologically active agent, such as clonidine or its derivatives, such as clonidine HCl for a prolonged period of time, such as 2 months, 3 months, 4 months, and even 4.5 months. The polymer is preferably a biodegradable polymer, such as poly(lactide-co-glycolide) or polylactic acid/polylactide. The challenge in using the HCl salt forms of drugs such as clonidine, is controlling the release of the highly water soluble drug for up to 4.5 months. It has been found that by controlling the particle size distribution of the drug powder, the drug distribution within the polymer matrix is more uniform and can be controlled. Therefore, the large aggregates, which cause rapid drug release can be eliminated. 117-. (canceled)18. A method of making an implantable medical device , the method comprising providing a biologically active agent as a powder , wherein at least 80% of the particles have a particle size between 5-50 micrometers in diameter;providing a polymer as a powder;combining the biologically active agent and polymer powders to form a powder mixture;melt mixing the powder mixture to form a melt mixture; andextruding the melt mixture to form the implantable medical device.19. The method of claim 18 , wherein the biologically active agent is spray dried prior to the providing step claim 18 , spray drying comprising the steps of:combining the biologically active agent with a liquid carrier; and spray drying the combined liquid carrier and biologically active agent under conditions sufficient to result in biologically active agent particles having an average particle size between about 5-50 micrometers in diameter.20. The method of claim 18 , wherein the biologically active agent is clonidine HCL.21. The method of claim 18 , wherein the biologically active agent is present in the implantable medical device in an amount between about 1-60% by weight.22. The method of ...

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14-11-2013 дата публикации

METHOD TO MINIMIZE CHAIN SCISSION AND MONOMER GENERATION IN PROCESSING OF POLY(L-LACTIDE) STENT

Номер: US20130300034A1
Принадлежит:

Methods of fabricating an implantable medical devices such as stents made from biodegradable polymers are disclosed that reduce or minimize chain scission and monomer generation during processing steps. The method includes processing a poly(L-lactide) resin having an number average molecular weight between 150 to 200 kD in an extruder in a molten state. A poly(L-lactide) tube is formed from the processed resin and a stent is fabricated from the tube. The number average molecular weight of the poly(L-lactide) of the stent after sterilization is 70 to 100 kD. 114-. (canceled)15. A method of making a stent comprising:providing poly(L-lactide) (PLLA) resin having an Mn between 150 to 200 kD;processing the PLLA resin in a molten state;forming a PLLA tube from the processed PLLA resin; andfabricating a stent from the PLLA tube.16. The method of claim 15 , further comprising sterilizing the stent with e-beam exposure. wherein a dose of the e-beam exposure is between 20 and 35 kGy.17. The method of claim 16 , wherein the e-beam exposure is 22-27 kGy.18. The method of claim 15 , wherein the Mn of the PLLA of the stent after sterilization is 70 to 100 kD.19. The method of claim 15 , wherein a processing temperature of the PLLA resin is 195° C. to 210° C.20. The method of claim 15 , wherein the PLLA resin is free of an organic solvent.21. A method of making a stent comprising:providing PLLA resin;processing the PLLA resin in a molten state at a temperature of 195° C. to 210° C.;forming a PLLA tube from the processed PLLA resin;fabricating a stent scaffolding from the PLLA tube; andsterilizing the stent scaffolding through exposure to e-beam radiation at a dose of 20-35 kGy, wherein an Mn of the sterilized stent scaffolding is at least 70 kD.22. The method of claim 21 , wherein the PLLA resin has an Mn between 150 to 200 kD prior to the processing step.23. A method of making a stent comprising:providing a stent scaffolding made of a polymer comprising PLLA; andsterilizing the ...

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14-11-2013 дата публикации

Implantable device for the delivery of histrelin and methods of use thereof

Номер: US20130302397A1
Автор: Harry Quandt, Petr Kuzma
Принадлежит: Endo Pharmaceuticals Solutions Inc

This invention is related to the use of polyurethane-based polymer as a drug delivery device to deliver biologically active histrelin at a constant rate for an extended period of time and methods of manufactures thereof. The device is very biocompatible and biostable, and is useful as an implant in patients (humans and animals) for the delivery of histrelin to tissues or organs.

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28-11-2013 дата публикации

Composition For Use In Occluding A Body Duct In A Living Creature

Номер: US20130312764A1
Автор: De Vries Jan Albert
Принадлежит:

A composition for use in occluding a body duct, such as female sterilization or blocking the urethra, in a living creature with a plug prepared in situ from a composition of an addition curable polysiloxane system. 1. An occlusive composition comprising an addition curable polysiloxane system.2. The occlusive composition of claim 1 , wherein the addition curable polysiloxane system comprises:a polysiloxane;a catalyst; anda crosslinker.3. The occlusive composition of claim 2 , wherein the addition curable polysiloxane system further comprises one or more of a tracer material claim 2 , a bactericidal agent and a filler.4. The occlusive composition of claim 1 , wherein the addition curable polysiloxane system comprises a polysiloxane having an ethylenically unsaturated moiety.5. The occlusive composition of claim 1 , wherein the addition curable polysiloxane system comprises an ethylenically unsaturated moiety terminated polysiloxane.6. The occlusive composition of claim 1 , wherein the addition curable polysiloxane system comprises vinyl terminated polysiloxane.7. The occlusive composition of claim 6 , wherein the vinyl terminated polysiloxane comprises vinyldialkyl terminated dimethyl polysiloxane.8. The occlusive composition of claim 6 , wherein the vinyl terminated polysiloxane comprises vinyldimethyl terminated polysiloxane.9. The occlusive composition of claim 1 , wherein the addition curable polysiloxane system comprises a Pt catalyst.10. The occlusive composition of claim 1 , wherein the addition curable polysiloxane system comprises a Pt(0) organic complex.11. The occlusive composition of claim 1 , wherein the addition curable polysiloxane system comprises a Pt(0) vinyl siloxane complex.12. The occlusive composition of claim 1 , wherein the addition curable polysiloxane system comprises a hydrosilicone crosslinker.13. The occlusive composition of claim 12 , wherein the hydrosilicone crosslinker comprises hydrogen dialkyl terminated siloxy groups.14. The ...

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05-12-2013 дата публикации

Injectable biodegradable particles for controlled therapeutic agent release

Номер: US20130323306A1
Автор: Jan Weber
Принадлежит: Boston Scientific Scimed Inc

In accordance with one aspect, embolic particles are provided that comprise a biodegradable polymer and a therapeutic agent, wherein the particles are configured such that, upon administration to a body lumen of a subject, the therapeutic agent is released from the time of administration up until a first point in time that ranges anywhere from about 1 week after administration to about 4 weeks after administration, at which point in time the therapeutic agent release ceases. The particles are also configured such that particles remain present in the body lumen from the first point in time at which therapeutic agent release ceases up to a second point in time that ranges anywhere from about 2 weeks to about 12 months after the first point in time, at which point the particles are completely degraded. Other aspects pertain to methods of making such particles. Still other aspects pertain to injectable compositions that comprise such particles and to methods of treatment that employ such injectable compositions.

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05-12-2013 дата публикации

IMPLANTABLE MEDICAL DEVICES FABRICATED FROM POLYURETHANES WITH BIODEGRADABLE HARD AND SOFT BLOCKS AND BLENDS THEREOF

Номер: US20130324676A1
Автор: Wang Yunbing
Принадлежит: Abbott Cardiovascular Systems Inc.

Medical devices, such as stents, fabricated at least in part from a polymer composite including a biodegradable elastomeric phase dispersed within a biodegradable polymeric matrix are disclosed. The composite is composed of a polyurethane block copolymer including soft polymer blocks and a hard polymer blocks. 1. A method of fabricating a stent comprising:allowing a hard polymer diol, a soft polymer diol, and a di-isocyanate to react to form a biodegradable polyurethane comprising hard polymer blocks and soft polymer blocks joined by di-urethane linkages; and forming a stent body comprising the polyurethane, wherein the soft blocks have a greater toughness than the hard blocks at physiological conditions.2. The method of claim 1 , further comprising blending the polyurethane with a glassy matrix polymer claim 1 , wherein the stent body comprises the polyurethane dispersed within the glassy matrix polymer.3. The method of claim 1 , wherein the hard blocks are selected from the group consisting of PLLA and PLGA claim 1 , and wherein the soft blocks are selected from the group consisting of PCL claim 1 , PTMC claim 1 , PHB claim 1 , and PDO.4. The method of claim 1 , wherein the soft blocks are selected from the group consisting of P(CL-co-GA) claim 1 , P(TMC-co-GA) claim 1 , P(HB-co-GA) claim 1 , and P(DO-co-GA) and wherein the hard blocks are selected from the group consisting of PLLA or PLGA.5. The method of claim 1 , wherein the di-isocyanate comprises an aliphatic di-isocyanate or an aromatic di-isocyanate.6. The method of claim 1 , wherein the di-isocyanate is selected from the group consisting of di-isocyanatomethane claim 1 , di-isocyanatobutane claim 1 , di-isocyanatoethane claim 1 , di-isocyanatohexane claim 1 , di-isocyanatocubane claim 1 , lysine di-isocyanate claim 1 , and di-isocyanatocycloehexane. This application is a division of U.S. patent application Ser. No. 12/014,714 filed Jan. 15, 2008, the entire disclosure is incorporated herein by reference.1. ...

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05-12-2013 дата публикации

IMPLANTABLE DRUG DELIVERY DEVICE AND METHODS

Номер: US20130324946A1
Принадлежит:

A method is provided for local controlled delivery of a drug to the seminal vesicle, the prostate, the ejaculatory duct, or the vas deferens of a patient in need of treatment. In one embodiment, the method includes implanting a resorbable drug delivery device within the seminal vesicle, the prostate, the ejaculatory duct, or the vas deferens of the patient. The drug delivery device may include an elastic device body housing at least one drug reservoir which contains at least one drug. In a preferred embodiment, the method further includes releasing the drug from the device in a controlled manner to, typically directly to, the seminal vesicle, the prostate, the ejaculatory duct, or the vas deferens. 1. An implantable medical device comprising:a resorbable, elastic device body having at least one elongated sidewall and at least one payload reservoir defined therein; anda payload stored in the payload reservoir,wherein the device body provides controlled release of the payload in vivo andwherein the implantable medical device is dimensioned and has an elasticity suitable for deployment of the medical device into a patient's bladder via the patient's urethra.2. The device of claim 1 , wherein the device is deformable from a first configuration suited for passing the medical device through a lumen of a urethral catheter or cystoscope into the patient's bladder to a second configuration suited for retaining the device in the bladder upon exiting the urethral catheter or cystoscope.3. The device of claim 1 , wherein the resorbable claim 1 , elastic device body comprises an elastomeric polymer.4. The device of claim 3 , wherein the elastomeric polymer is a hydrophobic elastomeric polyester.5. The device of claim 4 , wherein the hydrophobic elastomeric polyester is a poly(glycerol-sebacic acid).6. The device of claim 3 , wherein the elastomeric polymer comprises a poly(caprolactone) claim 3 , a polyanhydride claim 3 , an amino alcohol-based poly(ester amide) claim 3 , or a ...

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05-12-2013 дата публикации

Stents With Radiopaque Markers

Номер: US20130325106A1
Автор: Patrick P. Wu
Принадлежит: Abbott Cardiovascular Systems Inc

Various embodiments of stents with radiopaque markers arranged in patterns are described herein.

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26-12-2013 дата публикации

Cross-linked polymers and implants derived from electrophilically activated polyoxazoline

Номер: US20130345334A1
Принадлежит: Bender Analytical Holding BV

One aspect of the invention relates to a biocompatible, covalently cross-linked, polymer that is obtained by reacting an electrophilically activated polyoxazoline (EL-POX) with a nucleophilic cross-linking agent, said electrophilically activated POX comprising m electrophilic groups; and said nucleophilic cross-linking agent comprising n nucleophilic groups, wherein the m electrophilic groups are capable of reaction with the n nucleophilic groups to form covalent bonds; wherein m≧2, n≧2 and m+n≧5; wherein at least one of the m electrophilic groups is a pendant electrophilic group and/or wherein m≧3; and wherein the EL-POX comprises an excess amount of electrophilic groups relative to the amount of nucleophilic groups contained in the nucleophilic cross-linking agent. The invention further relates to biocompatible medical products comprising such a cross-linked POX-polymer. Also provided is a kit for producing a biocompatible, cross-linked POX-polymer. The invention further provides a tissue adhesive medical product comprising at least 1% by weight of dry matter of EL-POX, said EL-POX comprising at least 2 electrophilic groups, including at least one pendant electrophilic group. The polymers according to the invention have excellent implant and/or sealing characteristics.

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23-01-2014 дата публикации

Biocompatible, Biodegradable Polyurethane Materials With Controlled Hydrophobic to Hydrophilic Ratio

Номер: US20140023725A1
Автор: Sylwester Gogolewski
Принадлежит: DePuy Synthes Products Inc

The biocompatible, biodegradable materials in the solid and/or liquid form are based on segmented linear polyurethanes and/or segmented crosslinked polyurethanes based on A) one or more biocompatible polyols susceptible to hydrolytic and/or enzymatic degradation having a molecular weight of 100 to 20,000 dalton and a number of active hydroxyl groups per molecule (functionality) of at least two or higher; B) one or more diisocyanates and/or triisocyanates; and C) one or more low molecular weight chain extenders having a molecular weight of 18 to 1000 dalton and the functionality of at least two or higher.

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30-01-2014 дата публикации

CRUSH RECOVERABLE POLYMER SCAFFOLDS

Номер: US20140031921A1
Принадлежит: Abbott Cardiovascular Systems Inc.

A medical device includes a polymer scaffold crimped to a catheter having an expansion balloon. The scaffold, after being deployed by the balloon, provides a crush recovery of about 90% after the diameter of the scaffold has been pinched or crushed by 50%. The scaffold has a pattern including an asymmetric closed cell connecting links connecting the closed cells. 122-. (canceled)23. A balloon-expandable medical device for being implanted in a peripheral vessel of the body , comprising: configured for being crimped to a balloon,', 'the scaffold having a pattern of interconnected elements comprising rings interconnected by links, and', 'the scaffold having an expanded diameter when plastically deformed from a crimped state by the balloon,, 'a scaffold formed from a polymer tube'}wherein the scaffold attains greater than 90% of the expanded diameter after being crushed by an amount equal to at least 33% of the expanded diameter; andwherein at least a portion of the links include at least one hinge point or a pre-designated fracture point formed in the link.24. The medical device of claim 23 , wherein the interconnected elements further comprise struts forming the rings claim 23 , and wherein an aspect ratio (AR) of the width to wall thickness of a strut is between 0.4 and 1.4.25. The medical device of claim 23 , wherein a scaffold wall thickness is between 0.008 inches and 0.014 inches and the scaffold expanded diameter is between 5 mm and 8 mm.26. The medical device of claim 24 , wherein the rings include crowns claim 24 , nd wherein the crowns have a maximum crown angle between about 90 degrees and 115 degrees when the scaffold has the expanded diameter.27. The medical device of claim 23 , wherein the rings are formed by struts claim 23 , the rings include crowns having crown angles claim 23 , and there are no more than 9 crowns in a ring and 3 links connecting any ring to an adjacent ring claim 23 , andwherein prior to crimping the scaffold to the balloon the ...

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06-02-2014 дата публикации

Methods for Manufacturing Delivery Systems and Systems Thereof

Номер: US20140037707A1
Принадлежит: Evonik Corp

Described herein are methods for reducing and achieving the desired release of an agent from a delivery system. The desired release kinetics are achieved by exposing the surface of the delivery system with a fluid for a desired period of time.

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06-02-2014 дата публикации

PENDANT HYDROPHILE BEARING BIODEGRAADABLE COMPOSITIONS AND RELATED DEVICES

Номер: US20140037711A1
Автор: IYER Ananth, PARAKKA James
Принадлежит: DSM IP ASSETS B.V.

The instant invention relates to a composition comprising at least one polymer having the structure A-B-A′, wherein A and A′ may be the same or different and each is a degradable polyester component and wherein B is the reaction product resulting from the reaction between a diol, having one or more pendant oligomeric or polymeric groups, and A and A′. 1. A composition comprising at least one polymer having the structure A-B-A′ , wherein A and A′ may be the same or different and each is a degradable polyester component and wherein B is the reaction product resulting from the reaction between a diol , having one or more pendant oligomeric or polymeric groups , and A and A′.2. The composition of wherein A and A′ each comprise a poly(hydroxy carboxylic acid).3. The composition of claim 2 , wherein said poly hydroxy carboxylic acid is a member selected from the group consisting of glycolide claim 2 , lactide claim 2 , β-propiolactone claim 2 , β-butyrolactone claim 2 , γ-butyrolactone claim 2 , δ-valerolactone claim 2 , ε-caprolactone claim 2 ,1 claim 2 ,5-dioxepan-2-one claim 2 , pivalolactone and 1 claim 2 ,4-dioxane-2-one.4. The composition of claim 1 , wherein the degradable polyester comprises aliphatic polycarbonate segments within the A and A′ chains in the AB-A′ structure.5. The composition of claim 1 , wherein B includes a pendant oligomeric or polymeric oxyalkylene moiety.6. The composition of claim 1 , wherein the pendant group in B comprises a hydrophilic group.7. The composition of claim 6 , wherein the hydrophilic group comprises a polyvinylpyrrolidone or a poly(dimethylacrylamide) group.8. The composition according to claim 1 , wherein one or more of the polymers are chain extended with a diisocyanate compound to form a polyesterurethane.9. The composition according to claim 1 , wherein one or more of the polymers are end-capped with a monofunctional isocyanate compound.10. The composition of claim 1 , wherein the one or more polymers are reacted with an ...

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13-02-2014 дата публикации

Implantable medical devices fabricated from branched polymers

Номер: US20140046006A1
Принадлежит: Abbott Cardiovascular Systems Inc

Implantable medical devices fabricated from branched polymers are disclosed.

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13-02-2014 дата публикации

Coatings for the Manufacture and Application of Polyhydroxyalkanoate Medical Devices

Номер: US20140046351A1
Принадлежит: TEPHA, INC.

Biocompatible coatings and spin finishes that can be applied to polyhydroxyalkanoate (PHA) polymers, and medical devices made from PHA polymers, have been developed. The coatings impart good lubricity to PHA polymers, particularly to fibers and braids made from these materials, making the coatings ideal for use on medical devices such as PHA braided sutures. The spin finishes can be applied to PHA fibers to facilitate their manufacture, and also for their conversion to other products, including medical textiles. The spin finishes serve to protect multifilament fiber bundles, and keep them intact following extrusion, and also to impart lubricity to the fiber bundles and monofilament fibers so that they are not damaged in subsequent processing steps particularly in textile processing. The coating reduces tissue drag of, for example, braided sutures. 142.-. (canceled)43. A knitted or woven surgical mesh comprising poly-4-hydroxybutyrate monofilament fibers , wherein the mesh is knit or woven using monofilament fibers coated with polyethylene glycol sorbitan monolaurate , and the polyethylene glycol sorbitan monolaurate is removed using a scouring process such that the residual level of polyethylene glycol sorbitan monolaurate on the mesh is less than 0.5 weight percent.44. The mesh of wherein the mesh has been scoured by water to remove the polyethylene glycol sorbitan monolaurate claim 43 , and wherein the temperature of the water is above 4° C.45. The mesh of wherein ultrasound is used to enhance the scouring of the mesh.46. The mesh of wherein a water-soluble detergent is used to enhance the scouring of the mesh.47. The mesh of wherein the scoured mesh is heat set in hot water.48. The mesh of wherein the scoured mesh is washed with alcohol or aqueous alcohol.49. The mesh of claim 43 , wherein the mesh further comprises one or more of the following: collagen claim 43 , plasticizer claim 43 , nucleant claim 43 , dye claim 43 , therapeutic agent claim 43 , calcium ...

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27-02-2014 дата публикации

BIODEGRADABLE NITRIC OXIDE GENERATING POLYMERS AND RELATED BIOMEDICAL DEVICES

Номер: US20140058049A1
Принадлежит: Northwestern University

Disclosed herein is a biodegradable nitric oxide-generating polymer comprising a nitric oxide-releasing NO (NONOate) functional group. The polymer can be applied to various medical devices for the treatment of various diseases such as thrombosis and restenosis. 116-. (canceled)17. A biocompatible elastomeric polymer comprising an amine-crosslinked elastomer of a citric acid-aliphatic diol pre-polymer.18. The method of wherein the aliphatic diol is 1 claim 17 ,8-octanediol.19. The polymer of wherein the amine crosslinker is trans-4-hydroxy-L-proline.20. The polymer of wherein the aliphatic diol is 1 claim 19 ,8-octanediol.21. A method of preparing the biocompatible elastomeric polymer of comprising:a) synthesizing a prepolymer of citric acid and aliphatic diol;b) post-polymerizing the prepolymer with a crosslinkable amine unit to form a post-polymer; andc) reacting the post-polymer with NO gas.22. The method of wherein the crosslinkable amine unit is 4-hydroxy-L-proline.23. The method of wherein the aliphatic diol is 1 claim 22 ,8-octanediol.25. The method of wherein the aliphatic diol is 1 claim 24 ,8-octanediol.26. The method of wherein the amine diol is N claim 25 ,N-bis(2-hydroxyethyl)-.ethylenediamine.29. The biomedical device of wherein the amine crosslinker is trans-4-hydroxy-L-proline.30. The biomedical device of wherein the aliphatic diol is 1 claim 29 ,8-octanediol.31. The biomedical device of wherein the device is an implantable device.32. The biomedical device of wherein the device is an implantable device. This application claims priority benefit from application Ser. No. 61/192,654 filed Sep. 19, 2008, incorporated herein by reference in its entirety.This invention relates to certain spontaneous, biodegradable nitric oxide-generating citric acid-based polymers having a nitric oxide-releasing NO functional group. Specifically, the invention relates to diazeniumdiolated aliphatic biodegradable elastomers for use in the prevention of thrombosis and ...

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06-03-2014 дата публикации

Reactive Oxidative Species Generating Materials and Methods of Use

Номер: US20140065199A1
Принадлежит: WL Gore and Associates Inc

Materials capable of delivering stabilized free radicals to targeted treatment sites. The materials comprise semi-crystalline, hydrolytically degradable polymers that are subjected to ionizing radiation to create stabilized free radicals therein. Upon exposure to oxygen containing aqueous media, the materials generate reactive oxidative species which are useful in biological processes.

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06-03-2014 дата публикации

Enhanced low friction coating for medical leads and methods of making

Номер: US20140067028A1
Принадлежит: Cardiac Pacemakers Inc

An implantable or insertable medical device can include a silicone substrate and a plasma-enhanced chemical vapor deposition coating on the silicone substrate. The coating may include a silicon-containing compound. A method of forming the coating is also provided.

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13-03-2014 дата публикации

BIODEGRADABLE TRIBLOCK COPOLYMERS FOR IMPLANTABLE DEVICES

Номер: US20140072609A1
Принадлежит: Abbott Cardiovascular Systems Inc.

The present invention is directed to polymeric materials made of biodegradable, bioabsorbable triblock copolymers and implantable devices (e.g., drug-delivery stents) containing such polymeric materials. The polymeric materials may also contain at least one therapeutic substance. The polymeric materials are formulated so as to improve the mechanical and adhesion properties, degradation, biocompatibility and drug permeability of such materials and, thus, implantable devices formed of such materials. 1. A composition comprising a biodegradable triblock copolymer of the structure A-B-A′ , wherein:{'sub': g', 'm, 'the A and A′ blocks each independently are hard blocks having a Tor Tabove body temperature;'}{'sub': g', 'g', 'm, 'the B block is a soft block having a Tless than the Tor Tof the A and A′ blocks;'}{'sub': 'n', 'the A, B and A′ blocks each independently have a polymer number-average molecular weight (M) from about 1 kDa to about 500 kDa; and'}the A and A′ blocks may be the same or different.2. The composition of claim 1 , further comprising at least one dihydroxyaryl group conjugated to the polymer ends of the triblock copolymer.3. The composition of claim 2 , wherein the at least one dihydroxyaryl group contains a 3 claim 2 ,4-dihydroxyphenyl moiety.4. The composition of claim 1 , further comprising at least one biocompatible moiety.5. The composition of claim 1 , further comprising at least one additional biologically absorbable polymer.6. The composition of claim 1 , further comprising at least one biologically active agent selected from the group consisting of antiproliferative claim 1 , antineoplastic claim 1 , antimitotic claim 1 , anti-inflammatory claim 1 , antiplatelet claim 1 , anticoagulant claim 1 , antifibrin claim 1 , antithrombin claim 1 , antibiotic claim 1 , antiallergic and antioxidant substances.7. The composition of claim 6 , wherein the at least one biologically active agent is selected from the group consisting of paclitaxel claim 6 , ...

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20-03-2014 дата публикации

Implantable medical devices fabricated from branched polymers

Номер: US20140081417A1
Принадлежит: Abbott Cardiovascular Systems Inc

Stent scaffolds comprising branched biocompatible polymers are disclosed.

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27-03-2014 дата публикации

Crosslinkable Polyisobutylene-Based Polymers and Medical Devices Containing the Same

Номер: US20140088218A1
Принадлежит: Cardiac Pacemakers, Inc.

The present invention pertains to crosslinkable and crosslinked polyisobutylene-based polymers, to compositions that contain such polymers, and to medical devices that are formed using such polymers. According to one aspect, the present invention pertains to crosslinkable and crosslinked compositions that comprise a copolymer that comprises a polyisobutylene segment and two or more reactive groups. According to another aspect, the present invention pertains to medical devices that contain such compositions. According to another aspect, the present invention pertains to methods of making medical devices using such compositions. 117-. (canceled)18. A medical device comprising a polymeric region that comprises a crosslinked polymer that comprises a polyisobutylene segment.19. The medical device of claim 18 , wherein the polymer is a crosslinked urethane claim 18 , urea or urethane/urea copolymer.20. The medical device of claim 18 , wherein the polymeric region comprises a crosslinking agent residue.21. The medical device of claim 18 , wherein said polymeric region is a coating or adhesive layer that is applied to a medical device component.22. The medical device of claim 18 , wherein said polymeric region is a molded or extruded medical device component.23. The medical device of claim 18 , wherein said medical device is selected from stent claim 18 , a heart valve claim 18 , an implantable electrical lead claim 18 , a pacemaker claim 18 , a defibrillator and a heart failure device.24. The medical device of claim 18 , wherein said polymeric region further comprises a therapeutic agent.2532-. (canceled) This present application is a divisional of U.S. patent application Ser. No. 12/860,002, filed Aug. 20, 2010, the disclosure of which is hereby incorporated by reference in its entirety, and which claims the benefit of U.S. provisional application 61/235,931, filed Aug. 21, 2009, which is incorporated by reference herein in its entirety.The present invention relates to ...

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27-03-2014 дата публикации

ELASTOMERIC AND DEGRADABLE HIGH-MINERAL CONTENT POLYMER COMPOSITES

Номер: US20140088618A1
Автор: Kutikov Artem, Song Jie
Принадлежит:

The invention provides novel compositions of hydroxyapatite and block co-polymers, methods of their preparation, and uses thereof, wherein the co-polymers have degradable hydrophobic blocks and hydrophilic blocks for stable interfacing with hydroxyapatite, resulting in stable polymer-hydroxyapatite suspensions. The super-hydrophilicity, strengthened mechanical integrity, and retained structural integrity of the HA-PELA composite in aqueous environment represent major advantages over the HA-PLA composites for skeletal tissue engineering applications. 1. A composition comprising hydroxyapatite and a block co-polymer , wherein the block co-polymer comprises hydrophilic blocks and degradable hydrophobic blocks , wherein the composition exhibits hydrophilic surface properties , elasticity and retains mechanical integrity in aqueous environment.2. The composition of claim 1 , wherein the composition possess a stable structural interface between the co-polymer and the hydroxyapatite.3. The composition of claim 1 , wherein the hydroxyapatite is present in a weight percentage of at least 1%.46-. (canceled)7. The composition of claim 1 , wherein the block co-polymer comprises blocks of poly(ethylene glycol) and polyesters.8. The composition of claim 1 , wherein the block co-polymer comprises blocks of poly(ethylene glycol) and poly(lactic acid).9. The composition of claim 1 , characterized by the properties of biodegradability claim 1 , aqueous stability and eletrospinability.10. The composition of claim 1 , wherein the block co-polymer is electrospun into fibrous composite mesh.11. The composition of claim 1 , wherein the block co-polymer is crosslinked forming a three-dimensional polymer-hydroxyapatite network.12. The composition of claim 1 , wherein the composition is a three-dimensional network prepared rapid prototyping.13. The composition of claim 1 , wherein the composition is characterized by a shape-memory property.14. An article of manufacture made from a ...

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03-04-2014 дата публикации

Methods of fabricating stents with enhanced fracture toughness

Номер: US20140094899A1
Принадлежит: Abbott Cardiovascular Systems Inc

Stents and methods of manufacturing a stents with enhanced fracture toughness are disclosed.

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10-04-2014 дата публикации

METHOD OF FABRICATING A LOW CRYSTALLINITY POLY(L-LACTIDE) TUBE

Номер: US20140100649A1
Принадлежит: Abbott Cardiovascular Systems Inc.

Methods of fabricating a low crystallinity polymer tube for polymers subject to strain-induced crystallization. The low crystallinity tube may be further processed to make an implantable medical device. 120-. (canceled)21. A stent comprising:a cylindrically-shaped scaffold including a biodegradable polymer having a pattern of a plurality of interconnecting struts formed from a polymeric tube comprising the biodegradable polymer, wherein the biodegradable polymer of the polymer tube has a crystallinity of 20% to 50 the crystallinity comprises crystals of a spherulite form and a shish-kebob form with less than 5% of the crystals being of the spherulite form, wherein the stent is expandable within an anatomical lumen of a body.22. The stent of claim 21 , wherein 15% to 45% of the crystallinity is of the shish-kebob form.23. The stent of claim 21 , wherein the biodegradable polymer of the polymer tube comprises a crystallinity of 30% to 45%.24. The stent of claim 21 , wherein 25% to 40% of the crystallinity is of the shish-kebob form.25. The stent of claim 21 , wherein the polymer comprises poly(L-lactide).26. The stent of claim 21 , wherein the polymer comprises poly(L-lactide-co-glycolide).27. The stent of claim 26 , wherein the poly(L-lactide-co-glycolide) is 15 mol % L-lactide and 85% glycolide.28. The stent of claim 21 , wherein the polymer comprises poly(L-lactide-co-caprolactone).29. The stent of claim 21 , wherein the pattern is formed by cutting the pattern in the polymer tube. This application is a continuation of U.S. patent application Ser. No. 12/550,153 filed Aug. 28, 2009, and is incorporated by reference herein.1. Field of the InventionThis invention relates to methods of manufacturing polymeric medical devices, in particular, stents.2. Description of the State of the ArtThe discussion that follows is intended solely as background information to assist in the understanding of the invention herein; nothing in this section is intended to be, nor is it to ...

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06-01-2022 дата публикации

VASCULAR ANASTOMOTIC MEMBER COMPRISING SHAPE-MEMORY POLYMER

Номер: US20220000481A1
Принадлежит:

The present invention relates to an artificial blood vessel comprising a shape-memory polymer, and a vascular anastomotic member formed of a shape-memory polymer. An artificial blood vessel according to an embodiment of the present invention comprises a shape-memory polymer including photo-crosslinkable functional groups, the artificial blood vessel thus provided having a fusion point suitable for in vivo transplantation. Also, provided is a vascular anastomotic member which comprises a shape-memory polymer including photo-crosslinkable functional groups, and thus has a fusion point suitable for in vivo transplantation. 2. The vascular anastomotic member of claim 1 , wherein claim 1 , in Formula 1 claim 1 , R claim 1 , Rand Rare each independently hydrogen (H) or a methyl group claim 1 ,m and n are each independently an integer of 3 to 12,{'sub': 1', '2, 'A, Band Bare each independently oxygen (O) or sulfur (S),'}x and y represent mol % of a repeat unit,x+y is 100, and x is 88 to 94.3. The vascular anastomotic member of claim 1 , wherein the shape-memory polymer has a melting temperature of 30 to 48° C. on average.4. The vascular anastomotic member of claim 1 , wherein the shape-memory polymer has an average melting temperature of 28 to 42° C. after crosslinking.6. The vascular anastomotic member of claim 1 , wherein the vascular anastomotic member has a tubular shape inserted into ends of a first blood vessel and a second blood vessel.7. The vascular anastomotic member of claim 6 , wherein the vascular anastomotic member is changed according to the inner diameters of the first blood vessel and the second blood vessel at 28 to 42° C. or more on average.8. The vascular anastomotic member of claim 6 , wherein the vascular anastomotic member has a sectional thickness of 50 to 200 μm.9. The vascular anastomotic member of claim 6 , wherein the vascular anastomotic member has an inner diameter of 0.2 to 5 mm claim 6 , and the inner diameter of the vascular anastomotic ...

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06-01-2022 дата публикации

METHODS OF TREATMENT ASSOCIATED WITH ENDOVASULAR GRAFTS

Номер: US20220000896A1
Автор: Ning Kelvin
Принадлежит:

Methods and compositions for treatments associated with endovascular grafts, dissections, peripheral aneurysms, and neuro aneurysms are provided that deliver 1,2,3,4,6-pentagalloyl glucose (PGG) or analogues or derivatives thereof and/or LeGoo®. Also provided is a device to deliver 1,2,3,4,6-pentagalloyl glucose (PGG) or analogues or derivatives thereof or LeGoo® to the tissue to be treated. 1. A method for treating a leaking endovascular graft of a patient , comprising:positioning a first balloon in an artery in a region of the leaking endovascular graft;expanding the first balloon such that it presses against surfaces of the artery or the leaking endovascular graft in contact with a surface of the first balloon; anddelivering a therapeutic agent to tissue in the region of the leaking endovascular graft through pores in the first balloon.2. The method of claim 1 , wherein expanding the first balloon comprises introducing an inflation fluid into an interior volume of the first balloon.3. The method of claim 1 , wherein delivering the therapeutic agent comprises introducing a solution comprising the therapeutic agent into an interior volume of the first balloon claim 1 , the introduction of the solution being configured to expand and/or maintain an expanded state of the first balloon.4. The method of claim 1 , wherein expanding the first balloon comprises maintaining a pressure within an interior volume of the second balloon greater than a diastolic blood pressure of the patient and less than a systolic blood pressure of the patient.5. The method of claim 1 , wherein expanding the first balloon and delivering the therapeutic agent through the pores comprises introducing a solution into an interior volume of the first balloon claim 1 , and wherein the solution is introduced at a first volumetric flow rate to expand the first balloon and the solution is introduced at a second volumetric flow rate to deliver the therapeutic agent through the pores claim 1 , the first ...

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01-01-2015 дата публикации

METHOD FOR MANUFACTURING A POLYMER SHEET FOR USE AS AN IMMOBILIZATION ELEMENT

Номер: US20150000679A1
Принадлежит: ORFIT INDUSTRIES

The present invention relates to a method for manufacturing a polymer sheet for use as an immobilization element, wherein the sheet is at least partly made of a polymer material comprising a polymer from the group of polycaprolactone, a copolymer of polyethylene with at least one α-olefin having 3-10 C atoms, or a mixture of two or more of the aforementioned polymers, a photo-initiator, and a photo-cross-linker, wherein the polymer sheet has a thickness of 1.0 to 5 mm and wherein the polymer sheet is at least partially cured by exposing to UV radiation for the at least partially cross-linking of the polymer. 1. A method for manufacturing a polymer sheet for use as a non-invasive immobilization element for the immobilization of one or more body parts in a predetermined position , wherein a polymer sheet with a thickness of 1.0 to 5.0 mm , which is at least partially made of a polymer material comprising a polymer from the group of polycaprolactone , a copolymer of polyethylene with at least one a-olefin having 3-10 C atoms , or a mixture of two or more of the aforementioned polymers , and a photo-initiator , is at least partly cured by exposure to UV-radiation for the at least partial cross-linking of the polymer.2. Method according to claim 1 , wherein the polymer sheet contains at least a first and a second zone claim 1 , wherein the first and second zone have a different degree of cross-linking.3. Method according to claim 1 , wherein the polymer material further comprises a photo-cross-linker.4. Method according to claim 1 , wherein the sheet claim 1 , prior to exposure to UV radiation claim 1 , is cut into a desired shape.5. Method according to claim 1 , wherein the sheet claim 1 , prior to exposure to UV radiation claim 1 , is at least partially perforated.6. Method according to claim 5 , wherein the polymer sheet has an edge claim 5 , and wherein the edge claim 5 , prior to the exposure to UV radiation claim 5 , is not perforated.7. Method according to claim 1 ...

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07-01-2021 дата публикации

METHOD AND DEVICE FOR SURGERY

Номер: US20210001017A1
Автор: Heriot Wilson J.
Принадлежит:

The invention provides devices, methods and kits for surgery. More specifically, the invention provides a device for surgery comprising: a body comprising a handle; and one or hydrophobic or oleophilic extension or probe, wherein the device is adapted for removal of hydrophobic or oleophilic fluid. A method is also provided for removal of hydrophobic or oleophilic fluid, the method comprising: contacting the hydrophobic or oleophilic fluid with one or more hydrophobic or oleophilic extension or probe to thereby remove the hydrophobic or oleophilic fluid, whereby removal is by one or more of cohesive attraction, adhesion and capillary action. 1. A device for surgery comprising:a body comprising a handle; andone or hydrophobic or oleophilic extension or probe,wherein the device is adapted for removal of hydrophobic or oleophilic fluid.2. The device of claim 1 , wherein the device removes the hydrophobic or oleophilic fluid by one or more of cohesive attraction claim 1 , adhesion and capillary action; and wherein the removal is at least substantially specific for the hydrophobic or oleophilic fluid.3. The device of claim 1 , wherein the device does not apply any extraneous or additional force or energy.4. The device of claim 1 , wherein the device applies aspiration to assist in removal of the hydrophobic or oleophilic fluid.5. The device of claim 1 , wherein the device comprises a bore to allow passage of air for aspiration of fluid from an eye claim 1 , optionally claim 1 , the bore comprising an internal bore.6. The device of claim 5 , wherein the bore comprises a diameter of 5; 6; 7; 8; 9; 10; 11; 12; 13; 14; 15; 16; 17; 18; 19; 20; 21; 22; 23; 24; 25; 26; 27; 28; 29; 30; 35; 40 or greater than claim 5 , gauge.7. The device of claim 1 , for use in eye or vitreous surgery.8. A method for removal of hydrophobic or oleophilic fluid claim 1 , the method comprising:contacting the hydrophobic or oleophilic fluid with one or more hydrophobic or oleophilic extension or ...

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02-01-2020 дата публикации

EMULSIONS OR MICROEMULSIONS FOR USE IN ENDOSCOPIC MUCOSAL RESECTIONING AND/OR ENDOSCOPIC SUBMUCOSAL DISSECTION

Номер: US20200000926A1
Принадлежит: COSMO TECHNOLOGIES LTD.

The present invention relates to a pharmaceutical composition in form of emulsion or microemulsion and the use thereof as aid during endoscopic procedures in which it is injected in a target tissue in order to form a cushion. More in details, the invention relates to a method for performing an endoscopic procedure, which comprises injecting said pharmaceutical composition in form of emulsion or microemulsion in a target tissue of a patient, in order to form a cushion, which cushion is then optionally subjected to an endoscopic surgical procedure, such as a resection. 1. A kit comprising a pharmaceutical composition in a container , wherein the pharmaceutical composition comprises:(a) at least one poloxamer selected from poloxamer 124, poloxamer 188, poloxamer 237, poloxamer 338, and poloxamer 407, or a mixture thereof; and(b) means for keeping the pharmaceutical composition in liquid phase up to a temperature of about 40° C. in vitro.2. The kit according to claim 1 , wherein the container is selected from an ampoule claim 1 , a vial claim 1 , a bottle claim 1 , and a pre-filled syringe.3. The kit according to claim 2 , wherein the container is an ampoule.4. The kit according to claim 3 , wherein the ampoule contains from 10 mL to 50 mL of the pharmaceutical composition.5. The kit according to claim 2 , wherein the container is a vial.6. The kit according to claim 5 , wherein the vial contains from 10 mL to 50 mL of the pharmaceutical composition.7. The kit according to claim 2 , wherein the container is a bottle.8. The kit according to claim 2 , wherein the container is a pre-filled syringe.9. The kit according to claim 8 , wherein the pre-filled syringe contains from 5 mL to 10 mL of the pharmaceutical composition.10. A method for creating a cushion in a submucosal tissue in the gastrointestinal tract of a patient claim 8 , comprising injecting into the submucosal tissue a pharmaceutical composition comprising:(a) at least one poloxamer selected from poloxamer 124, ...

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02-01-2020 дата публикации

BIOABSORBABLE POLYMERIC COMPOSITION FOR A MEDICAL DEVICE

Номер: US20200000975A1
Принадлежит:

A crystallized bioabsorbable polymer scaffold comprises a polymer composition of poly (L-lactide-co-tri-methylene-carbonate) or poly (D-lactide-co-tri-methylene-carbonate) or poly (L-lactide-co-ε-caprolactone) or poly (D-lactide-co-ε-caprolactone) in the form of block copolymers of blocky copolymers, wherein the scaffold is cold-bendable. 1. A crystallized bioabsorbable polymer scaffold comprising a polymer composition of poly (L-lactide-co-tri-methylene-carbonate) or poly (D-lactide-co-tri-methylene-carbonate) or poly (L-lactide-co-ε-caprolactone) or poly (D-lactide-co-ε-caprolactone) in the form of block copolymers of blocky copolymers , wherein the scaffold is cold-bendable.2. The bioabsorbable polymer scaffold of claim 1 , wherein the scaffold is cold bendable at temperatures in a range of about 10° C. to about 30° C.3. The bioabsorbable polymer scaffold of claim 1 , wherein the polymer composition comprises poly (L-lactide-co-ε-caprolactone) or poly (D-lactide-co-ε-caprolactone).4. The bioabsorbable polymer scaffold of claim 1 , wherein the polymer composition comprises poly (L-lactide-co-ε-caprolactone).5. The bioabsorbable polymer scaffold of claim 1 , further comprising a poly (L-lactide) moiety or a poly (D-lactide) moiety or a poly L-lactide-co-PEG moiety or a poly D-lactide-co-PEG moiety.6. The bioabsorbable polymer scaffold of claim 1 , wherein the composition includes increased hydrophilicity and free molecular volume allowing for uptake of water.7. The bioabsorbable polymer scaffold of claim 1 , wherein the composition includes amorphous and semicrystalline polymer portions.8. The bioabsorbable polymer scaffold of claim 7 , wherein a crystallinity and tensile strength of the composition is adjustable by elongation of the semicrystalline portion.9. The bioabsorbable polymer scaffold of claim 1 , further comprising at least one radiopaque marker.10. A crystallized bioabsorbable polymer scaffold comprising a polymer composition of poly (L-lactide-co-tri- ...

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05-01-2017 дата публикации

PLASTICIZERS FOR A BIODEGRADABLE SCAFFOLDING AND METHODS OF FORMING SAME

Номер: US20170000930A1
Принадлежит:

Methods of making polymeric devices, such as stents, with one or more modifications such as addition of plasticizers, to improve processing, and the devices made by these methods. 1. A method of fabricating a medical device , the method comprising:processing a polymer to form a medical device or a polymer construct, the processing occurring at a high temperature, the high temperature being above the melting temperature of the polymer, if the polymer exhibits a melting temperature above 35° C., or if the polymer does not exhibit a melting temperature above 35° C., at a temperature 100° C. higher than the glass transition temperature (Tg) of the polymer, or 75° C., if 75° C. is greater than 100° C. above the Tg of the polymer; 'wherein the plasticizer is different from any solvent used in production of the polymer;', 'adding a plasticizer to the polymer prior to, during, or both prior to and during the processing of the polymer;'}removing at least 75 weight % of the plasticizer from the processed polymer, the removal comprising heating the processed polymer to and maintaining the processed polymer at a temperature above the glass transition temperature of the polymer or above 28° C., if the glass transition temperature of the polymer is lower than 25° C., and below the melting temperature of the polymer, if the polymer has a melting temperature above 28° C., or if the polymer does not have a melting temperature above 28° C., below the temperature that is 75° C. greater than the glass transition temperature of the polymer, or below 60° C., if 60° C. is higher than 75° C. greater than the glass transition temperature of the polymer;optionally executing one or more additional operations on the medical device or on the polymer construct;wherein the polymer has a number average molecular weight as measured by GPC using polystyrene standards of at least 250,000 g/mole, but not more than 3,000,000 g/mole, the polymer has a weight average molecular weight of at least 300,000 ...

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05-01-2017 дата публикации

PARA-XYLENE FILMS AND THERAPEUTIC USES THEREOF

Номер: US20170000931A1
Принадлежит:

The present invention provides single sheet and compound para-xylene films for therapeutic uses. For example, the present invention provides single sheet para-xylene films useful as tissue separators and/or adhesion barriers in a subject, where the top and/or bottom surfaces of such films have a water contact angle between 75 and 95 degrees (e.g., to prevent adhesion formation). The present invention also provides compound films composed of at least two para-xylene polymer films with a therapeutic molecule layer in between. Such compound films, when used in vivo (e.g., as a tissue separator and to treat inflammation or atrial fibrillation) allow either therapeutic molecule elution through one of the para-xylene layers, or therapeutic molecule release when the compound film is pierced, such as when it is sutured in place. 1. An article of manufacture comprising: a polymer film with a top surface and a bottom surface ,wherein said polymer film consists essentially of a para-xylene polymer,wherein said polymer film has a thickness between 1 μm and 75 μm,wherein substantially all of said top surface has a water contact angle between 75 and 95 degrees,wherein substantially all of said bottom surface has a water contact angle between 75 and 95 degrees, andwherein said polymer film is sterilized and sized to serve as a tissue separator and/or adhesion barrier in a subject.2. The article of manufacture of claim 1 , wherein substantially all of said top surface is non-oxidized.3. The article of manufacture of claim 1 , wherein said top surface has a carbon to oxygen ratio of about 2:1 to about 18:1.4. The article of manufacture of claim 1 , wherein said top surface has a RMS roughness of about 1.0 nm to about 10.0 nm.5. The article of manufacture of claim 1 , wherein said top surface of said polymer film has a surface area between 10 cm2 and 400 cm2.6. The article of manufacture of claim 1 , wherein para-xylene polymer comprises parylene C.7. The article of manufacture of ...

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02-01-2020 дата публикации

SYSTEMS, DEVICES AND METHODS FOR THE CREATION OF A THERAPEUTIC RESTRICTION IN THE GASTROINTESTINAL TRACT

Номер: US20200001047A1
Принадлежит: Fractyl Laboratories Inc.

A system for treating a patient comprises a delivery device and injectate. The delivery device comprises an elongate shaft with a distal portion and at least one delivery element positioned on the elongate shaft distal portion. The delivery device is constructed and arranged to deliver the injectate through the at least one delivery element and into tissue to create a therapeutic restriction in the gastrointestinal tract. Methods of creating a therapeutic restriction are also provided. 1. (canceled)2. A method of treating a patient comprising:advancing a fluid delivery element to a location proximate a luminal segment of the gastrointestinal tract of the patient; anddelivering an injectate through the delivery element and into tissue proximate the luminal segment to create a therapeutic restriction in the luminal segment;wherein the therapeutic restriction causes a loss of weight to the patient.3. The method of claim 2 , wherein the therapeutic restriction is constructed and arranged to restrict the passage of food through a portion of the gastrointestinal tract of the patient.4. The method of claim 2 , wherein the therapeutic restriction is constructed and arranged to cause at least one of: early satiety; premature satiety; or satiety.5. The method of claim 2 , wherein the therapeutic restriction is constructed and arranged to alter an absorptive property and/or a secretive property of the gastrointestinal tract of the patient.6. The method of claim 2 , wherein the therapeutic restriction is created by injecting a volume of injectate of at least 1.0 mL.7. The method of claim 6 , wherein the therapeutic restriction is created by injecting a volume of injectate of at least 3.0 mL.8. The method of claim 2 , wherein the therapeutic restriction is created by injecting a volume of injectate of no more than 20.0 mL.9. The method of claim 8 , wherein the therapeutic restriction is created by injecting a volume of injectate of no more than 10.0 mL.10. The method of claim 2 ...

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20-01-2022 дата публикации

Single-use contact tip for tonometer

Номер: US20220015631A1
Принадлежит: Reichert Inc

A contact tip for a contact tonometer has a body including a contact surface, and a coating applied to the contact surface. The coating includes a light-activated material and a biocompatible water soluble adhesive for adhering the coating to the contact surface. The water soluble adhesive dissolves upon contact with the corneal tear film during a tonometric measurement, thereby releasing the light-activated material into the tear film. The present disclosure further provides a single-use tonometer contact tip product which includes a sterilized contact tip having the mentioned contact surface coating, and an opaque package containing the sterilized contact tip.

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20-01-2022 дата публикации

MULTILAYER SYNTHETIC RUBBER COMPOSITIONS

Номер: US20220016322A1
Принадлежит:

Provided are multilayer synthetic rubber compositions formed from a layer of a styrene block copolymer composition and a layer of one or more synthetic elastomers, such as polychloroprene, polyisoprene, nitrile rubber, styrene butadiene rubber, butyl rubber and polyurethane. The multilayer compositions find use in the manufacture of thin walled articles, for example gloves, particularly medical or industrial gloves. 1. A multilayer composition comprising:(a) a first layer comprising a styrene block copolymer (SBC) composition, said styrene block copolymer (SBC) composition comprising one or a mixture of SBCs of number average molecular weight (Mn) above 100,000 g/mol;(b) a second layer comprising one or more synthetic elastomers and, optionally, one or more styrene block copolymers (SBCs); and(c) optionally, one or more further layers.2. A multilayer composition according to claim 1 , wherein the SBC composition of the first layer comprises at least one SBC selected from the group consisting of linear claim 1 , radial or star SEBS claim 1 , SEPS claim 1 , SEEPS claim 1 , SBSS claim 1 , SIS claim 1 , SBS claim 1 , SIBS claim 1 , and combinations thereof.3. (canceled)4. A multilayer composition according to claim 1 , wherein the SBC of the first layer comprises an SBC with a saturated elastomeric mid-block.5. A multilayer composition according to claim 1 , wherein the SBC composition of the first layer further comprises one or more plasticizers.6. A multilayer composition according to claim 5 , wherein the plasticizer comprises a liquid or a mixture of liquid saturated polyolefins compatible with the midblock (elastomeric block) of the SBC.7. A multilayer composition according to claim 5 , wherein the plasticizer is selected from one or more vegetable oils claim 5 , such as sunflower claim 5 , rapeseed claim 5 , or coconut oil or an oligomer or other elastomer that possesses sufficient compatibility with the rubbery mid-blocks claim 5 , such as a low molecular weight ...

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14-01-2016 дата публикации

Molding Process And Products Formed Thereby

Номер: US20160007976A1
Принадлежит:

A reusable surgical implement is provided that is formed of a core positioned within an enclosure. The core is formed of a suitable rigid, and optionally flexible material to enable the implant to conform to the desired use for the implement in a surgical procedure. The material forming the enclosure is also stretchable and flexible to accommodate the configuration and/or any flexing of the core, and is biologically inert to enable the implant to be sterilized after use for use in subsequent surgical procedures while protecting the material forming the core. The enclosure can be molded around the core in separate portions or components using multiple molding steps to form an enclosure with the desired attributes. 1. A reusable surgical implement comprising:a) a core; andb) an enclosure formed around the core of at least one molded component to completely enclose the portion of the core on which the at least one molded component is disposed.2. The implement of wherein the core is formed of a shape memory material.3. The implement of wherein the enclosure is formed of first portion and a second portion.4. The implement of wherein the first portion and the second portion are formed of different materials.5. The implement of wherein the first portion and second portion are formed of different materials.6. The implement of wherein the first portion and the second portion are capable of mating claim 3 , co-mingling or otherwise joining to one another to form a seamless enclosure.7. The implement of wherein the first portion is formed of a number of first sections spaced from one another on the core.8. The implement of wherein the second portion is formed of a number of second sections spaced from one another and between adjacent first sections.9. The implement of wherein at least one of the first section or the second sections includes one or more features formed therein.10. The implement of wherein the features do not intersect the core.11. The implement of wherein the ...

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14-01-2016 дата публикации

INTRAVASCULAR STENT WITH HELICAL STRUTS AND SPECIFIC CROSS-SECTIONAL SHAPES

Номер: US20160008149A1
Автор: CHEN Hsin, Hsiao Hao-Ming
Принадлежит:

The present invention relates to a stent, comprising: a plurality of radially-expandable rings arranged along a longitudinal axis, wherein each radially-expandable ring may comprise a plurality of bar arms and a plurality of crowns, and adjacent crowns are connected by the bar arms therebetween; and a plurality of connectors between the radially-expandable rings for connecting such radially-expandable rings; wherein a cross-sectional shape of the bar arms, the crowns or the connectors may comprise helical structures, specific cross-sectional shapes, or a combination thereof. New stent manufacturing techniques, such as the 3D additive printing, could be used for making these proposed stents feasible. 1. A stent , comprising:a plurality of radially-expandable rings arranged along a longitudinal axis, wherein each of the radially-expandable rings comprises a plurality of bar arms and a plurality of crowns, wherein adjacent crowns are connected by the bar arms therebetween; anda plurality of connectors disposed between the radially-expandable rings for connecting the radially-expandable rings;wherein a cross-sectional shape of at least one of the bar arms, the crowns, or the connectors is selected from the group of circular, oval, triangular, rectangular, hexagonal, octagonal, polygonal, and airfoil shapes, or any combination thereof.2. The stent as claimed in claim 1 , wherein at least one of the bar arms claim 1 , the crowns claim 1 , and the connectors comprises a helical structure.3. The stent as claimed in claim 2 , wherein the connectors comprise the helical structures.4. The stent as claimed in claim 2 , wherein the bar arms comprise the helical structures.5. The stent as claimed in claim 3 , wherein the bar arms and the connectors comprise the helical structures.6. The stent as claimed in claim 5 , wherein the bar arms claim 5 , the crowns claim 5 , and the connectors comprise the helical structures.7. The stent as claimed in claim 2 , wherein the helical ...

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14-01-2016 дата публикации

Resorbable membrane for guided bone regeneration

Номер: US20160008519A1

The invention relates to membranes for guided bone regeneration, comprising a biodegradable polymer that has been treated with a plasma on one of the faces thereof, and on which at least one or more nanometric layers of active oxides has been deposited on one or both of the faces. The invention also relates to uses of and methods for producing said membranes and to implants based thereon.

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14-01-2016 дата публикации

Oxygen-absorbing resin composition

Номер: US20160008800A1
Принадлежит: Mitsubishi Gas Chemical Co Inc

The oxygen-absorbing resin composition of the present invention at least contains a polyester compound containing a constitutional unit (a) having a predetermined tetralin ring and a constitutional unit (b) derived from a predetermined polyfunctional (trivalent or more) compound, and a transition metal catalyst.

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11-01-2018 дата публикации

THERMAL PROCESSING OF POLYMER SCAFFOLDS

Номер: US20180008438A1
Принадлежит:

Methods are disclosed including thermally processing a scaffold to increase the radial strength of the scaffold when the scaffold is deployed from a crimped state to a deployed state such as a nominal deployment diameter. The thermal processing may further maintain or increase the expansion capability of the scaffold when expanded beyond the nominal diameter. 119.-. (canceled)21. The method of claim 20 , further comprising crimping the scaffold from the processed state to a crimped state over a delivery balloon having a nominal diameter.22. The method of claim 20 , wherein the thermal processing increases the crest angles of the rings.23. The method of claim 20 , wherein a diameter of the scaffold is fixed during the thermal processing which causes the crest angles to increase as the arc length decreases.24. The method of claim 20 , wherein the scaffold is made of a PLA polymer and the temperature is 70 to 90° C. and the time is 5 to 15 min.25. The method of claim 20 , further comprising disposing the scaffold over a tubular mandrel prior to the thermal processing claim 20 , wherein the scaffold diameter decreases to the outer diameter of the mandrel during the thermal processing.26. The method of claim 20 , wherein the thermal processing decreases an arc length of each ring.27. The method of claim 20 , wherein crest angles are less than 100° in the fabricated state and the temperature claim 20 , time claim 20 , scaffold diameter decrease claim 20 , or any combination thereof are selected such that the crest angles are 100° to 150° in the processed state.28. The method of claim 20 , wherein a thickness of the scaffold is 75 to 100 microns in the fabricated state and increases 10 to 30% during the thermal processing.29. The method of claim 20 , wherein the thermal processing is performed during a coating process.30. The method of claim 20 , wherein the fabricated state is an as-cut scaffold.31. The method of claim 20 , wherein a width of the scaffold decreases during ...

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14-01-2021 дата публикации

PLASTIC CONTAINER

Номер: US20210007930A1
Принадлежит:

A plastic container has superior storage stability for pharmaceutical ingredients exhibiting a high affinity to plastic and can be mass-produced at low cost. The container has a bag body formed into a bag shape by a sheet member with a storage part on the inside thereof, and a tubular port member attached to the bag body, wherein one end of the tubular port member communicates with the storage part and an opening part of the other end is exposed outside of the bag body. The sheet member is formed from two or more layers including a base resin layer and an innermost layer formed from an amorphous polymer, as a main component, formed by polymerizing at least one type of olefin monomer, having a cyclic hydrocarbon skeleton, and the port member is formed from a resin having a crystalline polyolefin having no cyclic hydrocarbon skeleton, as a main component. 1. A plastic container comprising: a bag body which is formed into a bag shape by a sheet member and has a storage part on the inside thereof; and a tubular port member attached to said bag body , in which one end of the tubular port member communicates with the storage part and an opening part of the other end is exposed outside of the bag body ,wherein said sheet member is formed from two or more layers including a base resin layer and an innermost layer, and said innermost layer is formed from an amorphous polymer, as a main component, formed by polymerizing at least one type or two or more types of olefin monomers, in which at least one type of said olefin monomers is a monomer having a cyclic hydrocarbon skeleton, andwherein said port member is formed from a resin having a crystalline polyolefin having no cyclic hydrocarbon skeleton, as a main component.2. The plastic container according to claim 1 , wherein a relationship between a content contact area S(cm) of said bag body and a content contact area S(cm) of said port member satisfies the following (Expression 1):{'br': None, 'i': ≤S', '/S, 'sub': P', 'B, '0. ...

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11-01-2018 дата публикации

Coated Vaso-Occlusive Device and Methods for Treatment of Aneurysms

Номер: US20180008748A1
Принадлежит:

A method is described herein for the treatment of intracranial aneurysms. The method comprises inserting into an aneurysm an embolism coil coated with a polymeric coating comprising a genipin, such as genipin or a derivative thereof, thereby increasing the stability of clots within the aneurysm. According to one example, the coating is a poly(L-lactide-co-glycolide) (PLGA) is used to release genipin to crosslink fibrin clots thereby creating more stable occlusions. Increased clotting can improve segregation of the weakened portion of the blood vessel from the rest of the vasculature and reduce the risk of recurrence. 137-. (canceled)38. A method of creating and stabilizing a blood clot in a patient , comprising:inducing clot formation in a patient's vasculature; andcontacting the clot with genipin or a crosslinking genipin derivative to stabilize the clot.39. The method of claim 38 , wherein the genipin or a crosslinking genipin derivative is incorporated into a bioerodible polymer.40. The method of claim 38 , wherein the step of inducing clot formation in the patient comprises feeding a vaso-occlusive device into the patient's vasculature to induce clot formation.41. The method of claim 40 , wherein the vaso-occlusive device is an embolism coil.42. The method of claim 40 , wherein the genipin or cross-linking genipin derivative comprises a filament comprising core and a controlled release coating layer on the core comprising the genipin or a crosslinking genipin derivative.43. The method of claim 42 , wherein the filament comprises between the core substrate and the controlled release coating layer a polymeric intermediary layer.44. The method of claim 43 , wherein the polymeric intermediary layer is a hydrogel claim 43 , or wherein the controlled release coating layer is a non-bioerodible polymer comprising the genipin or crosslinking genipin derivative.45. The method of claim 40 , wherein the genipin or crosslinking genipin derivative is provided as a filament ...

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11-01-2018 дата публикации

Composite Lacrimal Insert and Related Methods

Номер: US20180008751A1
Принадлежит: Mati Therapeutics Inc.

Lacrimal implants, methods of making lacrimal implants, and methods of treating ocular, respiration or other diseases or disorders using lacrimal implants are disclosed. 1. A lacrimal implant comprising: the first portion including a first biocompatible polymer configured to swell less than 100 wt % when in contact with an aqueous medium,', 'the second portion including a second biocompatible polymer configured to swell greater than 100 wt % when in contact with an aqueous medium;, 'an implant body, including first and second portions, sized and shaped for at least partial insertion into a lacrimal canaliculus,'}wherein the first and second biocompatible polymers adhere at a junction between the first portion and the second portion.2. The lacrimal implant of claim 1 , wherein the first biocompatible polymer is a polyurethane polymer or copolymer.3. The lacrimal implant of claim 1 , wherein the second biocompatible polymer is a hydrogel-forming polyurethane polymer or copolymer.4. The lacrimal implant of claim 1 , wherein the junction comprises an intermediate member including a third biocompatible polymer claim 1 , the third biocompatible polymer configured to adhere to both the first biocompatible polymer and the second biocompatible polymer claim 1 , and configured to swell upon contact with an aqueous medium to a greater degree than the first polymer but to a lesser degree than the second polymer.5. The lacrimal implant of claim 4 , wherein the third polymer comprises a polyurethane polymer or copolymer claim 4 , a polyurethane-silicone copolymer claim 4 , a polyurethane-carbonate copolymer claim 4 , an aliphatic polyurethane claim 4 , an aromatic polyurethane claim 4 , or any combination thereof.6. The lacrimal implant of claim 1 , wherein the first portion comprises a base member extending from a proximal end claim 1 , configured to sit at or near a lacrimal punctum when implanted and including a first diameter claim 1 , to a distal end portion claim 1 , ...

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11-01-2018 дата публикации

SIDE-CHAIN CRYSTALLIZABLE POLYMERS FOR MEDICAL APPLICATIONS

Номер: US20180008753A1
Принадлежит:

Side-chain crystallizable (SCC) polymers are useful in various medical applications. In certain applications, heavy atom containing side-chain crystallizable polymers (HACSCCP's) are particularly useful. An example of a HACSCCP is a polymer that comprises a main chain, a plurality of crystallizable side chains, and a plurality of heavy atoms attached to the polymer. In certain configurations, the heavy atoms are present in an amount that is effective to render the polymer radiopaque. A polymeric material that includes an HACSCCP may be fabricated into a medical device useful for at least partially occluding a body cavity. For example, such a medical device may be an embolotherapy product. A polymeric material that includes a SCC polymer may also be fabricated into other medical devices, such as stents. 1. A method of treatment comprising:introducing a medical device into a body cavity of a mammal in an amount that is effective to at least partially occlude the body cavity, andforming a channel through the medical device;wherein the medical device comprises a polymeric material; andwherein the polymeric material comprises an inherently radiopaque, side chain crystallizable polymer.2. The method of claim 1 , wherein the polymeric material is introduced into the body cavity in the presence of a mold.3. The method of claim 2 , wherein forming the channel comprises removing the mold from the body cavity.4. The method of claim 1 , wherein the side chain crystallizable polymer comprises heavy atoms.5. The method of claim 1 , wherein the side chain crystallizable polymer is biocompatible. This application is a divisional application, and claims the benefit and priority of, U.S. application Ser. No. 13/101,391, filed May 5, 2011, issued as U.S. Pat. No. 9,782,523, which is a divisional of U.S. patent application Ser. No. 11/335,771, filed Jan. 18, 2006, issued as U.S. Pat. No. 8,703,113, which is a continuation-in part of U.S. patent application Ser. No. 11/176,638, filed ...

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10-01-2019 дата публикации

LAYERED MEDICAL APPLIANCES AND METHODS

Номер: US20190008665A1
Принадлежит:

Medical appliances may be formed of multilayered constructs. The layers of the constructs may be configured with various physical properties or characteristics. The disposition and arrangement of each layer may be configured to create an overall construct with a combination of the individual properties of the layers. Constructs may be used to create vascular prostheses or other medical devices. 1. (canceled)3. The multilayered vascular prosthesis of claim 2 , wherein the axis of longitudinal expansion of at least one of the ePTFE sublayers is disposed at an angle between 0 degrees and 90 degrees to the axis of longitudinal expansion of at least one adjacent ePTFE sublayer.4. The multilayered vascular prosthesis of claim 2 , wherein the axis of longitudinal expansion of at least one of the ePTFE sublayers is perpendicular to the axis of longitudinal expansion of at least one adjacent ePTFE sublayer.5. The multilayered vascular prosthesis of claim 2 , wherein the axis of longitudinal expansion of at least one of the ePTFE sublayers is at an angle to a longitudinal axis of the multilayered vascular prosthesis.6. The multilayered vascular prosthesis of claim 2 , wherein at least one of the ePTFE sublayers is configured to be impermeable to red blood cell migration.7. The multilayered vascular prosthesis of claim 6 , wherein an average pore size of at least one of the ePTFE sublayers is different than an average pore size of at least one adjacent ePTFE sublayer.8. The multilayered vascular prosthesis of claim 6 , wherein pores of at least one of the ePTFE sublayers are misaligned with pores of at least one adjacent ePTFE sublayer such that a tortuous path is defined between the pores of the sublayers.9. The multilayered vascular prosthesis of claim 6 , wherein at least one of the ePTFE sublayers is coupled to a non-porous layer.10. A multilayered vascular prosthesis claim 6 , comprising:a luminal surface comprising a serially deposited fiber layer; andan expanded ...

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27-01-2022 дата публикации

Platelet-activated bioadhesive stent coating as an anti-migration mechanism

Номер: US20220023510A1
Автор: Michelle Fater
Принадлежит: Boston Scientific Scimed Inc

A stent having an inner surface and an outer surface, the stent comprising a coating composition comprising a platelet-activated adhesive on at least a portion of the outer surface thereof.

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09-01-2020 дата публикации

UNIVERSAL CUT GUIDE WITH PIN ENGAGING MEMBER

Номер: US20200008813A1
Принадлежит:

A saw guide for guiding a surgical saw or drill includes a guide portion having one or more guide slots, the one or more guide slot or hole configured to guide a surgical saw or drill. The guide portion has an attachment portion forming a clamping slot between the guide portion and the attachment portion. A clamp locking mechanism is assembled to the guide portion and has one or more cams in contact with the attachment portion. An alignment system for surgical bone cutting procedures is provided that includes bone pins inserted within a virtual plane relative to a cut plane to be created on a subject's bone. One of the aforementioned guides is configured to be received onto the bone pins, one or more guide slots within said guide, said one or more guide slots configured to guide a surgical saw to make surgical cuts on the subject's bone. 1. A saw guide for guiding a surgical saw to create one or more planar cuts on a bone , comprising:a guide portion having one or more guide slots, the one or more guide slot configured to guide a surgical saw to create the one or more bone cuts on the bone;an attachment portion assembled to the guide portion to form a clamping slot between the guide portion and the attachment portion; anda clamp locking mechanism having one or more cams assembled to the guide portion, the one or more cams in contact with the attachment portion to adjust the size of the clamping slot as the one or more cams are rotated to lock on to a set of bone pins inserted in the bone.2. (canceled)3. (canceled)4. The saw guide of wherein said guide portion is a stationary jaw body having the guide slot extending through the body claim 1 , the stationary jaw body further comprising a bottom surface distanced from the guide slot and having a plurality of grooves for contracting the bone pins claim 1 , a first coupling rod extending from a first side of the bottom surface and a second coupling rod extending from an opposing side of the bottom surface claim 1 , ...

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11-01-2018 дата публикации

MEDICAL DEVICE AND PLASTICIZED NYLON MATERIAL

Номер: US20180009966A1
Автор: CHEN Mingfei
Принадлежит:

A plasticized nylon and a medical device including plasticized nylon. The medical device may be a dilatation balloon. Also disclosed are methods of plasticizing nylon. 3. The medical device of claim 1 , wherein the nylon comprises a nylon copolymerized with a polyether.4. The medical device of claim 1 , wherein the nylon is selected from Nylon-6 claim 1 , Nylon-7 claim 1 , Nylon-8 claim 1 , Nylon-9 claim 1 , Nylon-10 claim 1 , Nylon-11 claim 1 , Nylon-12 claim 1 , Nylon-13 claim 1 , Nylon-14 claim 1 , Nylon-15 claim 1 , Nylon-16 claim 1 , Nylon-17 claim 1 , Nylon-18 claim 1 , Nylon-6 claim 1 ,6 claim 1 , Nylon-6 claim 1 ,8 claim 1 , Nylon-6 claim 1 ,10 claim 1 , Nylon-6 claim 1 ,12 claim 1 , Nylon-6 claim 1 ,14 claim 1 , Nylon-8 claim 1 ,8 claim 1 , Nylon-8 claim 1 ,10 claim 1 , Nylon-8 claim 1 ,12 claim 1 , Nylon-8 claim 1 ,14 claim 1 , Nylon-10 claim 1 ,10 claim 1 , Nylon-10 claim 1 ,12 claim 1 , Nylon-8 claim 1 ,12 claim 1 , Nylon-10 claim 1 ,14 claim 1 , Nylon-12 claim 1 ,12 claim 1 , Nylon-12 claim 1 ,14 claim 1 , Nylon-14 claim 1 ,16 claim 1 , and combinations thereof.5. The medical device of wherein the nylon comprises a block copolymer of polyether-co-Nylon-12.6. The medical device of wherein the plasticizer is present in an amount of up to 10 wt-% claim 1 , based on the total weight of the plasticized nylon.7. The medical device of wherein the plasticizer is present in an amount sufficient to decrease the flexural modulus of the nylon by at least 10%.8. The medical device of wherein the medical device comprises a balloon.9. The medical device of wherein the balloon is a dilatation balloon.10. The medical device of wherein the medical device comprises a catheter or medical tubing.11. The medical device of wherein the plasticized nylon is in the form of a film.14. The plasticized nylon of wherein the nylon comprises a nylon copolymerized with a polyether.15. The plasticized nylon of wherein the nylon is selected from Nylon-6 claim 12 , Nylon-7 claim 12 , ...

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03-02-2022 дата публикации

LACRIMAL IMPLANT DETECTION

Номер: US20220031507A1
Принадлежит: Mati Therapeutics, Inc.

This document discusses, among other things, an apparatus comprising a lacrimal implant insertable at least partially into a lacrimal punctum. The lacrimal implant comprises an implant core, and an implant body. The implant body includes a cavity sized and shaped to receive the implant core. At least one of the implant core and the implant cavity includes a detection device configured to allow automatic detection of the lacrimal implant with a separate detector device. 1. An apparatus comprising:a lacrimal implant insertable at least partially into a lacrimal punctum, the lacrimal implant comprising:an implant core; andan implant body, wherein the implant body includes a cavity sized and shaped to receive the implant core, andwherein at least one of the implant core and the implant cavity includes a detection device configured to allow automatic detection of the lacrimal implant with a separate detector device.2. The apparatus of claim 1 , wherein the detection device includes a radio frequency identifier (RFID) chip configured to communicate a detection signal to the detector device.3. The apparatus of claim 1 , wherein the detection device includes a luminescent material configured to reflect light to the detector device.4. The apparatus of claim 3 , wherein the luminescent material includes a quantum dot.5. The apparatus of claim 1 , wherein the detection device includes an ultrasonically reflective material configured to reflect ultrasonic energy to the detector device.6. The apparatus of claim 1 , wherein the detection device includes a ferromagnetic material that is capable of retaining a ferromagnetic property after application and removal of an external magnetic field claim 1 , wherein the retained ferromagnetic property is detectable by the detector device.7. The apparatus of claim 1 , wherein the detection device includes a magnetic material to retain a magnetic field detectable by the detector device claim 1 , wherein the magnetic material comprises at ...

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03-02-2022 дата публикации

Radiopaque medical components and devices

Номер: US20220031915A1
Принадлежит: DSM IP ASSETS B.V.

Disclosed are medical components, formulations for making medical components, methods of forming medical components, and methods of making medical devices from the medical components. The medical components possess radiopacity. In an embodiment, a medical component comprises from 5 to 50 wt % of a polyurethane and from 50 to 95 wt % of a radiopacifier, based on the total weight of the medical component, wherein the medical component has a thickness of from 0.025 to 1 mm.

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19-01-2017 дата публикации

STENT MADE FROM AN ULTRA HIGH MOLECULAR WEIGHT BIOABSORBABLE POLYMER WITH HIGH FATIGUE AND FRACTURE RESISTANCE

Номер: US20170014250A1
Автор: Kleiner Lothar W.
Принадлежит:

A stent made from an ultra high molecular weight bioabsorbable polymer is disclosed herein. The bioabsorbable polymer can have a Mw greater than 1 million g/mole or greater than 2 million g/mole. Methods of making the ultra high molecular weight polymer stent without degrading the molecular weight are further disclosed. 1. A method of making a stent body for supporting a vascular lumen , comprisingimmersing a cylindrical member in a solution including a bioabsorbable polymer dissolved in a fluid, wherein the bioabsorbable polymer has an inherent viscosity greater than 6 dl/g or has a weight average molecular weight greater than 1 million g/mole,removing the member from the solution, wherein a portion of the solution remains on the surface of the member upon removal from the solution;removing solvent from the solution remaining on the member to form a tubular layer of the bioabsorbable polymer on the member;repeating the immersion step, removal from the solution step, and removal of the solvent step to form a final tubular layer of bioabsorbable polymer on the member of a desired thickness; andforming a stent body from the final tubular layer.2. The method claim 1 , wherein the member is removed from the solution in less than 30 seconds.3. The method claim 1 , wherein the member is immersed with its cylindrical axis perpendicular to the surface of the solution.4. The method claim 1 , wherein the member is rotated 180° prior to repetition of the immersion step.5. The method claim 1 , further comprising radially expanding the final tubular layer and forming the stent body from the expanded tube.6. The method claim 1 , wherein the solution further comprises a therapeutic agent claim 1 , and the final tubular layer comprises some of the therapeutic agent. This application is a divisional application of U.S. patent application Ser. No. 12/422,783 filed Apr. 13, 2009, which is incorporated by reference herein.Field of the InventionThis invention relates to methods of ...

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19-01-2017 дата публикации

COMPOSITIONS AND DEVICES OF POLY-4-HYDROXYBUTYRATE

Номер: US20170014552A1
Принадлежит:

Compositions of P4HB with high purity have been developed. The compositions are prepared by washing P4HB biomass prior to solvent extraction, and precipitating P4HB from solution. The same solvent is preferably used to wash the P4HB biomass, and as a non-solvent to precipitate the polymer from a P4HB solvent solution. The highly pure P4HB compositions are suitable for preparing implants. The implants may be used for the repair of soft and hard tissues. 1. A composition comprising a polyhydroxyalkanoate (PHA) polymer obtained by a process comprising: suspending a PHA polymer biomass in ethanol for a period of time effective to extract lipids into the ethanol , separating the PHA polymer biomass from the ethanol by solid-liquid separation , collecting the ethanol-washed biomass , and extracting the PHA polymer into a solvent.2. The composition of wherein the polymer is precipitated with a non-solvent for the polymer claim 1 , harvested claim 1 , and dried.3. The composition of wherein the weight average molecular weight of the polymer is from 50 claim 1 ,000 to 1.2 million Da.4. The composition of sterilized with cold ethylene oxide gas claim 1 , gamma-irradiation claim 1 , or electron beam irradiation.5. The composition of used for soft or hard tissue repair claim 4 , regeneration or replacement.6. The composition of wherein the composition is used as a coating on a medical device.7. The composition of wherein the composition is used to form a medical device.8. The composition of wherein the PHA polymer is poly-4-hydroxybutyrate.9. The composition of wherein the composition forms a fiber wherein the fiber has a tensile strength of greater than 126 MPa.10. The composition of wherein the composition is used to form a yarn wherein the tenacity of the yarn is greater than 0.5 grams per denier.11. The composition of or formed into a suture or textile.12. The medical device of wherein the device is selected from the group: suture claim 7 , barbed suture claim 7 , braided ...

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18-01-2018 дата публикации

Analyte Sensors Having a Membrane with Low Temperature Sensitivity

Номер: US20180014761A1
Принадлежит:

Embodiments of the present disclosure relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have a membrane with low temperature sensitivity. The sensing layer is disposed on a working electrode of in vivo and/or in vitro analyte sensors, e.g., continuous and/or automatic in vivo monitoring using analyte sensors and/or test strips. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring. 167-. (canceled)68. An electrode assembly , comprising:an electrode;a sensing layer disposed on the electrode, the sensing layer comprising an analyte responsive enzyme; anda diffusion limiting polymeric membrane disposed on the sensing layer, wherein the polymeric membrane comprises a pyridine-based polymer, an ethylene oxide substituent, and a propylene oxide substituent,wherein diffusion of an analyte through the diffusion limiting membrane to the sensing layer does not change more than 5% per ° C. over a range of physiological temperatures.69. The electrode assembly of claim 68 , wherein the sensing layer comprises a glucose-responsive enzyme.70. The electrode assembly of claim 69 , wherein the glucose-responsive enzyme comprises glucose oxidase.71. The electrode assembly of claim 70 , wherein the sensing layer further comprises a redox mediator.72. The electrode assembly of claim 71 , wherein the redox mediator comprises a ruthenium-containing complex or an osmium-containing complex.73. The electrode assembly of claim 71 , wherein the redox mediator is bound to a polymer.74. The electrode assembly of claim 68 , wherein the analyte responsive enzyme is bound to a polymer.75. The electrode assembly of claim 68 , wherein the pyridine-based polymer comprises a poly(4-vinylpyridine)-co-polystyrene polymer.77. The electrode assembly of claim 68 , further comprising a counter electrode and a reference electrode.78. The electrode assembly of claim 68 , wherein at least a ...

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18-01-2018 дата публикации

METHOD FOR PREVENTING POSTOPERATIVE ADHESION OF AN ORGAN IN A WOUND SITE

Номер: US20180015208A1
Принадлежит:

Provided is a method for preventing postoperative adhesion of an organ in a wound site using the application of an antiadhesive material thereto. The antiadhesive material contains a poly-γ-glutamic acid having a weight-average molecular weight of 600,000 to 13,000,000, or a kinematic viscosity at 37° C. of 2 cSt to 15 cSt when dissolved in distilled water at a concentration of 0.05% by mass and/or a salt thereof, as an effective ingredient. The antiadhesive material may be in a form such as powder, and therefore, for example, is easy to handle even in relatively localized surgery such as endoscopic surgery and can more reliably prevent adhesion. 1. A method for preventing postoperative adhesion of an organ in a wound site comprising:applying powder form of a poly-γ-glutamic acid and/or a salt thereof to the wound site of a subject as it is,wherein the poly-γ-glutamic acid and/or a salt thereof is substantially uncrosslinked and is processed into powder form.2. The method of claim 1 , wherein the poly-γ-glutamic acid has a weight-average molecular weight of 600 claim 1 ,000 to 13 claim 1 ,000 claim 1 ,0003. The method of claim 1 , wherein the applying is performed with coating or spraying the poly-γ-glutamic acid and/or a salt thereof onto the wound site.4. The method of claim 1 , wherein the organ is digestive organ claim 1 , genital organ claim 1 , circulatory organ claim 1 , respiratory organ claim 1 , locomotive organ or sensory organ. This application is a divisional of co-pending U.S. patent application Ser. No. 14/419,260 filed Jul. 23, 2013, which was the United States national phase of International Application No. PCT/JP2013/069921 filed Jul. 23, 2013, which claims priority to Japanese Patent Application No. 2012-180332 filed Aug. 16, 2012, the disclosures of which are hereby incorporated in their entirety by reference.The present invention relates to a method of using an antiadhesive material, and more particularly relates to a method of using an ...

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17-01-2019 дата публикации

URETERAL STENT

Номер: US20190015226A1
Принадлежит:

A ureteral stent comprises an internal portion, which comprises a first polymer, and an external portion, which comprises a second polymer. The external portion surrounds the internal portion and has a plurality of radial projections that extend along the length of the ureteral stent. The second polymer has a Shore D hardness of 20-40 Shore D. The first polymer has a Shore D hardness that is at least 10 units greater than the Shore D hardness of the second polymer. 1. A ureteral stent , comprising:an internal portion, comprising a first polymer, andan external portion surrounding the internal portion and having a plurality of radial projections that extend along the length of the ureteral stent, comprising a second polymer,wherein the second polymer has a Shore D hardness of 20-40 Shore D, andthe first polymer has a Shore D hardness that is at least 10 units greater than the Shore D hardness of the second polymer.2. The ureteral stent of claim 1 , further comprising a lumen claim 1 , wherein the internal portion surrounds the lumen.3. The ureteral stent of claim 1 , wherein the external portion comprises 2-10 radial projections.4. The ureteral stent of claim 1 , wherein the external portion comprises 4-8 radial projections.5. The ureteral stent of claim 1 , wherein the external portion comprises 6 radial projections.6. The ureteral stent of claim 1 , wherein the ureteral stent does not include a lumen.7. The ureteral stent of claim 1 , wherein the ureteral stent is not coiled.8. The ureteral stent of claim 1 , wherein the first polymer has a hardness of 35-70 Shore D.9. The ureteral stent of claim 1 , wherein the first polymer has a hardness of 50-60 Shore D.10. The ureteral stent of claim 1 , wherein the first polymer has a hardness of 40 Shore D and the second polymer has a hardness of 25 Shore D.11. The ureteral stent of claim 1 , wherein the first polymer and the second polymer comprise thermoplastic elastomers.12. The ureteral stent of claim 1 , wherein the ...

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17-01-2019 дата публикации

PHARMACEUTICAL AND OTHER PACKAGING WITH LOW OXYGEN TRANSMISSION RATE

Номер: US20190015561A1
Принадлежит:

Processing an evacuated blood sample collection tube or other vessel by plasma enhanced chemical vapor deposition to apply a tie coating or layer (), a barrier coating or layer (), and optionally one or more additional coatings or layers. The tie coating or layer of SiOxCy is applied under partial vacuum and, while maintaining the partial vacuum unbroken in the lumen, the barrier coating or layer is applied. Then optionally, while maintaining the partial vacuum unbroken in the lumen, a pH protective coating or layer of SiOxCy can be applied. As a result of this processing, a coated vessel is produced having a lower gas permeation rate constant into the lumen than a corresponding vessel made by the same process except breaking the partial vacuum in the lumen between applying the tie coating or layer and applying the barrier coating or layer. Retention features are also described for keeping the vessels stoppered during exposure to reduced ambient pressure. 1. A method of processing a vessel comprising:a. providing a vessel comprising a wall consisting essentially of thermoplastic polymeric material defining a lumen, the wall having an interior surface facing the lumen and an exterior surface;b. drawing a partial vacuum in the lumen;c. while maintaining the partial vacuum unbroken in the lumen, applying a tie coating or layer of SiOxCy by a tie PECVD coating process comprising applying sufficient power to generate plasma within the lumen while feeding a gas comprising a linear siloxane precursor, optionally oxygen, and optionally an inert gas diluent, producing a tie coating or layer of SiOxCy, wherein x is from about 0.5 to about 2.4 and y is from about 0.6 to about 3, each as determined by X-ray photoelectron spectroscopy (XPS), on the interior surface;d. while maintaining the partial vacuum unbroken in the lumen, extinguishing the plasma;e. while maintaining the partial vacuum unbroken in the lumen, applying a barrier coating or layer by a barrier PECVD coating ...

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17-01-2019 дата публикации

Adhesion prevention agent comprising injectable thermosensitive wood based-oxidized cellulose nanofiber

Номер: US20190015564A1
Принадлежит:

The present invention provides a method for preparing an injectable thermosensitive hydrogel for preventing adhesion including mixing methyl cellulose, polyethylene glycol, oxidized cellulose nanofibers and carboxymethyl cellulose. The injectable thermosensitive hydrogel for preventing adhesion is a sol at a low temperature and induces rapid gelation upon in vivo implantation due to thermosensitivity. In addition, the hydrogel can be rapidly changed into physical hydrogel without separate additives or chemical reaction during in vivo condition. In addition, the injectable thermosensitive hydrogel for preventing adhesion exhibits excellent biodegradability and biocompatibility, has no cytotoxicity, inhibits in vitro migration of rat bone marrow mesenchymal stem cells (rBMSCs), and exhibits anti-adhesion efficacy in a rat model of sidewall defect-cecum abrasion in vivo, thus being useful as an effective anti-adhesive agent. 1. A method for preparing an injectable thermosensitive hydrogel for preventing adhesion comprising:mixing methyl cellulose, polyethylene glycol, oxidized cellulose nanofibers and carboxymethyl cellulose;adding water to the resulting mixture, followed by heating, to prepare a mix solution; andcooling and stirring the solution to prepare an injectable thermosensitive hydrogel for preventing adhesion.2. The method according to claim 1 , wherein the injectable thermosensitive hydrogel shows a sol-gel transition depending on temperature.3. The method according to claim 1 , wherein the injectable thermosensitive hydrogel is gelled in vivo.4. The method according to claim 1 , wherein oxidized cellulose nanofibers are derived from wood.5. The method according to claim 1 , wherein the methyl cellulose claim 1 , the polyethylene glycol claim 1 , the oxidized cellulose nanofibers and the carboxymethyl cellulose are mixed in a weight ratio of 1 to 3:1:0 to 1:0 to 1.6. The method according to claim 1 , wherein the methyl cellulose claim 1 , the polyethylene ...

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16-01-2020 дата публикации

METHOD AND DEVICE FOR ENHANCED TRANSDERMAL VISUALIZATION OF MEDICAL DEVICES

Номер: US20200015930A1
Принадлежит:

Implantable and/or insertable devices having a near-IR fluorescing material that allows the device to be visualized through a patient's skin. Also described herein are apparatuses for imaging devices having a near-IR fluorescing material, and methods of imaging devices having a near-IR fluorescing material from within the body, including methods of modifying an implanted device having near-IR fluorescing material. 1. An arteriovenous shunt (AV shunt) implant device that is configured to be visible through the patient's skin using near-infrared (near-IR) illumination , the device comprising:an elongated tubular body the body comprising polytetrafluoroethylene (PTFE) and having an inner lumen forming an inner layer;a first middle layer extending at least partially over the inner layer, the first middle layer comprising a first substrate and a near-IR dye, wherein the near-IR dye is at a concentration of between 0.0001% to 0.5% w/w and comprises one or more of: 1,1′,3,3,3′,3′-Hexamethylindotricarbocyanine iodide (HITCI), and a rylene dye; anda first outer layer extending over the first middle layer and sealing the first middle layer between the first outer layer and the inner layer.2. The device of claim 1 , wherein the near-IR dye is at a concentration of between 0.001% w/w and 0.1% w/w.3. The device of claim 1 , wherein the tubular body comprises a second middle layer separate from the first middle layer claim 1 , wherein the second middle layer comprises a second substrate and a second near-IR dye.4. The device of claim 3 , wherein the second middle layer is covered by the first outer layer or a second outer layer extending over the second middle layer and sealing the second middle layer between the second outer layer and the inner layer.5. The device of claim 3 , wherein the second near-IR dye is the same as the first near-IR dye and the second substrate is the same as the first substrate.6. The device of claim 1 , wherein the first substrate comprises silicone.7. ...

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15-01-2015 дата публикации

Use of Reverse Thermosensitive Polymers to Control Biological Fluid Flow Following a Medical Procedure

Номер: US20150018872A1
Автор: Wilkie James A.
Принадлежит:

One aspect of the present invention relates to a method to control biological fluid flow at a site in a mammal by use of an in situ formed polymer plug. In certain embodiments, the present invention relates to a method to control bleeding following a catheterization procedure, a method to control leakage of cerebral spinal fluid following a lumbar puncture, a method to seal a fistula, or a method to control the flow of serous fluid after a lymphadenectomy. In certain embodiments, the polymer plug is generated in situ by temperature changes, pH changes or ionic interactions. In certain embodiments, the polymer plug comprises at least one optionally purified reverse thermosensitive polymer. 1. A method to control biological fluid flow at a site in a mammal by use of an in situ formed polymer plug , comprising the step of:allowing a viscous polymer composition to solidify at body temperature, thereby forming the polymer plug in situ.2. The method of claim 1 , further comprising the step of:injecting a viscous polymer composition directly into the site.3. The method of claim 1 , wherein the polymer plug is generated in situ by temperature changes claim 1 , pH changes or ionic interactions.4. The method of claim 1 , further comprising the steps of:injecting a first composition directly into the site in a mammal; andinjecting a second composition directly into the site in a mammal, wherein the first composition contacts the second composition, thereby forming the viscous polymer composition in situ.5. The method of claim 1 , wherein the method controls bleeding following a catheterization procedure claim 1 , controls leakage of cerebral spinal fluid following a lumbar puncture claim 1 , seals a fistula claim 1 , or controls the flow of serous fluid after a lymphadenectomy.6. The method of claim 1 , wherein the viscous polymer composition comprises at least one optionally purified reverse thermosensitive polymer.7. The method of claim 18 , wherein the at least one ...

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16-01-2020 дата публикации

Polycarbonate Containing Compounds and Methods Related Thereto

Номер: US20200017644A1
Принадлежит:

Disclosed herein are crosslinked polycarbonates, composition thereof and methods thereof. The crosslinked polycarbonates can be prepared from allyl or epoxy polycarbonates. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. 122-. (canceled)24. The compound of claim 23 , wherein the targeting peptide is a cancer targeting peptide.25. The compound of claim 23 , wherein the targeting peptide is N-methylmorpholine.26. A nanoparticle claim 23 , comprising the compound of .27. The nanoparticle of claim 26 , further comprising a therapeutic agent claim 26 , prophylactic agent claim 26 , a diagnostic agent claim 26 , or a mixture thereof.28. The nanoparticle of claim 26 , further comprising a cancer therapeutic agent.30. The compound of claim 29 , wherein the targeting peptide is a cancer targeting peptide.31. The compound of claim 29 , wherein the targeting peptide is N-methylmorpholine.32. A nanoparticle claim 29 , comprising the compound of .33. The nanoparticle of claim 32 , further comprising a therapeutic agent claim 32 , prophylactic agent claim 32 , a diagnostic agent claim 32 , or a mixture thereof.34. The nanoparticle of claim 32 , further comprising a cancer therapeutic agent.36. The method of claim 35 , wherein the targeting peptide is a cancer targeting peptide.37. The method of claim 36 , wherein the targeting peptide is N-methylmorpholine.38. The method of claim 35 , wherein the crosslinking thereby forms a nanoparticle.42. The method of claim 41 , wherein the targeting peptide is a cancer targeting peptide.43. The method of claim 42 , wherein the targeting peptide is N-methylmorpholine.44. The method of claim 42 , wherein the crosslinking thereby forms a nanoparticle. This application is a continuation of U.S. application Ser. No. 15/443,456, filed Feb. 27, 2017, which is a continuation of U.S. application Ser. No. 14/399,920, filed Nov. 7, 2014, which is a ...

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16-01-2020 дата публикации

ANTIMICROBIAL SILCONE RUBBER, PREPARATION METHOD THEREFOR AND USE THEREOF

Номер: US20200017651A1
Принадлежит:

Disclosed is an antimicrobial silicone rubber, functional macromolecules being chemically bonded to the surface of the silicone rubber and containing vinyl or ethynyl, and the functional macromolecules being chemically bonded to the surface of the silicone rubber by means of vinyl or ethynyl; the functional macromolecules comprise polyamino acid macromolecules of which the molecular structure is as shown in (I) and (II). The antimicrobial silicone rubber of the present invention has polyamino acid macromolecules chemically bonded to the surface of the silicone rubber and serves an antimicrobial function by means of the interaction of polyamino acid macromolecules with a negatively charged cell membrane in bacteria, providing a persistent antimicrobial effect and unlikely causing bacteria to develop any drug resistance; moreover, polyamino acid macromolecules bind to the surface of the silicone rubber by means of chemical bonding, preventing macromolecules from being precipitated and entering a cell, providing good biocompatibility. 3. The antimicrobial silicone rubber of claim 2 , wherein:the amino acid-N-carboxylic anhydride A is selected from one or more of N (ε)-benzyloxycarbonyl-L-lysine-N-carboxylic anhydride, N′-benzyloxycarbonyl-L-ornithine, L-histidine-N-carboxylic anhydride, and L-arginine-N-carboxylic anhydride;the amino acid-N-carboxylic anhydride B is selected from one or more of N (ε)-benzyloxycarbonyl-L-lysine-N-carboxylic anhydride, N′-benzyloxycarbonyl-L-ornithine-N-carboxylic anhydride, L-histidine-N-carboxylic anhydride, L-arginine-N-carboxylic anhydride, L-alanine-N-carboxylic anhydride, L-leucine-N-carboxylic anhydride, L-isoleucine-N-carboxylic anhydride, L-valine-N-carboxylic anhydride, L-phenylalanine-N-carboxylic anhydride, L-methionine-N-carboxylic anhydride, γ-benzyl-L-glutamic acid-carboxylic anhydride, and β-benzyl-L-aspartic acid-carboxylic anhydride.5. The antimicrobial silicone rubber of claim 4 , wherein:the N-vinylpyrrolidone ...

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28-01-2016 дата публикации

BIOABSORBABLE MEDICAL DEVICE WITH COATING

Номер: US20160022452A1
Автор: Cottone Robert J.
Принадлежит:

A biodegradable, bioabsorbable medical device with a coating for capturing progenitor endothelial cells in vivo and delivering a therapeutic agent at the site of implantation. The coating on the medical device is provided with a biabsorbable polymer composition such as a bioabsorbable polymer, copolymer, or terpolymer, and a copolymer or terpolymer additive for controlling the rate of delivery of the therapeutic agent. 1. An expandable stent , comprising bioabsorbable material and a coating , wherein the expandable stent comprises a plurality of first meandering strut patterns forming an interconnected mesh , and at least one second strut pattern comprising a hoop circumferential about the longitudinal axis of the expandable stent , wherein the second strut pattern crystallizes when the stent is expanded , and wherein the coating comprises a ligand.2. The expandable stent of claim 1 , wherein the second strut pattern further comprises a through-void.3. The expandable stent of claim 1 , wherein the bioabsorbable material comprises at least poly-L-lactide (PLLA).4. The expandable stent of claim 1 , wherein the ligand is configured to bind target cells in vivo.5. The expandable stent of claim 4 , wherein the ligand is a small molecule claim 4 , a peptide claim 4 , an antibody claim 4 , antibody fragments claim 4 , or combinations thereof and the target cell is a progenitor endothelial cell antigen.6. The expandable stent of claim 1 , wherein the bioabsorbable matrix comprises a natural or synthetic biodegradable polymer.7. The expandable stent of claim 1 , wherein the bioabsorbable matrix comprises at least one of the group consisting of: dextran claim 1 , tropoelastin claim 1 , elastin claim 1 , laminin claim 1 , fibronectin claim 1 , fibrin claim 1 , collagen claim 1 , basement membrane proteins claim 1 , and cross-linked tropoelastin.8. The expandable stent of claim 1 , comprising a pharmacological substance.9. The expandable stent of claim 8 , wherein the ...

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28-01-2016 дата публикации

Method of treating pleural abnormality

Номер: US20160022878A1
Принадлежит: National Taiwan University NTU

The invention relates to a method of treating pleural abnormalities in a subject in need thereof, comprising the steps of: (a) attaching a biodegradable polymeric membrane onto a pleural wound to elicit fibronectin from fibroblasts to cause fibrous adhesion; and (b) securing the membrane with securement products, including sutures, staples, and sealants. The present invention also relates to a biodegradable adhesion membrane used for treating pleural abnormalities, comprising: a biodegradable base material selected from the group consisting of polycaprolactone (PCL), polylactic acid or polylactide (PLA), polyhydroxybutyrate (PHB), poly(ethylene adipate), poly(butylene adipate) (PBA), chitosan, hyaluronic acid, and polyglycolic acid (PGA); wherein the thickness of the membrane is 0.1-1 mm.

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28-01-2016 дата публикации

MEDICAL IMPLEMENTS AND MEDICAL IMPLEMENT PRODUCTION METHODS

Номер: US20160022882A1
Принадлежит:

The present disclosure provides medical implements having films fixed to at least a portion of their surface. In embodiments, a medical implement of the present disclosure may include a substrate including a synthetic resin, a film including a methyl vinyl ether-maleic anhydride copolymer in combination with a polyether block amide fixed to at least a portion of a surface of the substrate, and a silver ion bound to the film. Methods for forming such medical implements are also provided. 120-. (canceled)21. A method comprising:contacting at least a portion of a surface of a substrate of a medical implement with a solution comprising a solubilized methyl vinyl ether-maleic anhydride copolymer in combination with a polyether block amide, the substrate comprising a synthetic resin;forming a film comprising methyl vinyl ether-maleic anhydride copolymer in combination with a polyether block amide, the film being fixed to the surface of the substrate;contacting the film with a silver ion that binds to the methyl vinyl ether-maleic anhydride copolymer in combination with the polyether block amide; andafter contacting the film with the silver ion, contacting the film with an antithrombotic substance to bind the antithrombotic substance to the film.22. The method of claim 21 , wherein the silver ion is derived from the group consisting of aqueous silver nitrate claim 21 , aqueous silver acetate claim 21 , aqueous silver perchlorate claim 21 , and combinations thereof.23. The method of claim 21 , wherein the silver ion is derived from silver nitrate.24. The method of claim 23 , wherein contacting the film with the silver ion comprises contacting the film with an about 5% aqueous silver nitrate solution.25. The method of claim 24 , wherein contacting the film with the silver ion comprises contacting the film with an about 80% aqueous silver perchlorate solution.26. The method of claim 21 , wherein the antithrombotic substance is selected from the groups consisting of urokinase ...

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10-02-2022 дата публикации

Embolization Device Constructed From Expansile Polymer

Номер: US20220039802A1
Принадлежит:

Devices for the occlusion of body cavities, such as the embolization of vascular aneurysms and the like, and methods for making and using such devices are described. 1. A device for implantation in an animal , comprising:a hydrogel having ionizable functional groups wherein said hydrogel comprises at least one macromer, further wherein said hydrogel is environmentally-responsive, and further wherein said hydrogel has an unexpanded bending resistance of about 0.1 mg to about 85 mg.2. A device according to claim 1 , wherein said macromer has a molecular weight of about 400 grams/mole to about 35 claim 1 ,000 grams/mole.3. A device according to claim 1 , wherein said hydrogel comprises polyethers claim 1 , polyurethanes claim 1 , derivatives thereof claim 1 , or combinations thereof.4. A device according to claim 1 , wherein said with ionizable functional groups comprise basic groups.5. A device according to claim 4 , wherein said basic groups comprise an amine claim 4 , derivatives thereof claim 4 , or combinations thereof.6. A device according to claim 5 , wherein said basic functional groups can be deprotonated at pHs greater than the pKa or protonated at pHs less than the pKa of said functional groups.7. A device according to claim 1 , wherein said with ionizable functional groups comprise acidic groups.8. A device according to claim 7 , wherein said acidic groups comprise a carboxylic acid claim 7 , derivatives thereof claim 7 , or combinations thereof.9. A device according to claim 8 , wherein said acidic functional groups can be protonated at pHs less than the pKa or de-protonated at pHs greater than the pKa of said functional groups.10. A device according to claim 1 , wherein said hydrogel comprises vinyl claim 1 , acrylates claim 1 , acrylamides claim 1 , methacrylates claim 1 , derivatives thereof claim 1 , or combinations thereof.11. A device according to claim 1 , wherein said macromer comprises poly(ethylene glycol) claim 1 , derivatives thereof claim 1 , ...

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25-01-2018 дата публикации

METHOD FOR MANUFACTURING DRUG-CONTAINING BIODEGRADABLE FIBER MATERIAL BY ELECTROSPINNING

Номер: US20180021485A1
Принадлежит: ORTHOREBIRTH CO., LTD.

The present invention addresses the problem of providing a drug formulation material with which localized sustained release of a drug at any site in the body is possible, and which has good bioabsorption and is absorbed and broken down by the body after sustained release of the drug. A drug formulation material that has an exceedingly high sustained release effect, and that solves the foregoing problem, was successfully developed by dissolving a biodegradable resin and a drug in a solvent to prepare a spinning solution, and spinning fibers from the spinning solution by electrospinning. 1. A bioabsorbable cotton-like material having a cotton- or nonwoven fabric-like structure , comprising a fibrous material that comprises a drug and a biodegradable resin and has an average outer diameter of 1 μm or more but 150 μm or less.2. The bioabsorbable cotton-like material according to claim 1 , wherein the fibrous material has an average molecular weight of 50 claim 1 ,000 or more but less than 1 claim 1 ,000 claim 1 ,000.3. The bioabsorbable cotton-like material according to claim 1 , whose bulk density is 0.01 g/cmto 0.1 g/cm.4. The bioabsorbable cotton-like material according to claim 1 , wherein the biodegradable resin is PLGA or a copolymer thereof.5. The bioabsorbable cotton-like material according claim 1 , wherein the drug is an anticancer agent.6. The bioabsorbable cotton-like material according to claim 1 , which has been subjected to sterilization treatment.7. A method for manufacturing a bioabsorbable cotton-like material claim 1 , comprising:step 1) dissolving a biodegradable resin and a drug in a solvent to prepare a spinning solution; andstep 2) spinning fibers from the spinning solution by electrospinning.8. The method of claim 7 , wherein in the step 2) claim 7 , the fibers are spun by electrospinning by applying a voltage between a nozzle part provided on a spinning solution extrusion side and a plate placed in an ethanol bath provided on a collector side to ...

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10-02-2022 дата публикации

Sealing agent for genitals

Номер: US20220040386A1
Принадлежит: Sanyo Chemical Industries Ltd

The present invention aims to provide a cervical canal sealant that can be used as a sealant to stop bleeding in the uterus and vaginal discharge, particularly, a cervical canal sealant that can block the cervical canal to inhibit amniotic fluid leakage and that can also be peeled off without damaging reproductive tissue. The present invention relates to a sealant for reproductive organs in which a cured product (X) at 25° C. has a storage modulus G′ of 200 to 2,000 kPa, the cured product (X) being a cured product obtained by curing the sealant for reproductive organs to a thickness of 120 to 150 μm.

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17-04-2014 дата публикации

End-Capped Poly(Ester Amide) Copolymers

Номер: US20140107148A1
Принадлежит: Abbott Cardiovascular Systems Inc

This invention relates to poly(ester amide)s (PEAs) comprising inactivated terminal amino and carboxyl groups, methods of synthesizing the inactivated PEAs and uses for them in the treatment of vascular diseases.

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17-04-2014 дата публикации

MEDICAL DEVICE COMPRISING MACHINED PARTS AND INJECTION MOLDED PARTS

Номер: US20140107299A1
Принадлежит: INVIBIO LIMITED

A medical device comprises parts made by injection moulding and parts made by machining such that the respective parts have similar colours, measured on the L*, a*, b* scale. The parts made by injection moulding may be made in a process which involves introducing molten material comprising polymeric material such as PEEK into a mould, wherein a mould surface which contacts the molten material is at a temperature of at least 210° C. and maintaining the molten material in the mould for at least 90 seconds. 2. A plurality of components according to claim 1 , wherein the L* at a first position on the first component has a value “X” and the L* at a first position on the second component has a value “Y” claim 1 , wherein the L* difference claim 1 , defined as X minus Y claim 1 , is less than 8.3. A plurality of components according to claim 1 , wherein the a* at said first position on the first component has a value “E” and the a* at said first position on the second component has a value “F” claim 1 , wherein the a* difference claim 1 , defined as F minus E claim 1 , is less than 0.5; and the b* at said first position on the first component has a value “P” and the b* at said first position on said second component has a value “Q” claim 1 , wherein the b* difference claim 1 , defined as Q minus P claim 1 , is less than 3.4. A plurality of components according to claim 1 , wherein said second component has an L* of greater than 60 claim 1 , an a* of less than 1.8 and a b* of less than 15.5. (canceled)6. A plurality of components according to claim 1 , wherein said first and second components comprise the same type of polymeric material of formula I.7. A plurality of components according to claim 1 , wherein said first and second components have substantially the same composition.8. A plurality of components according to claim 1 , wherein said first and second components comprise polyetheretherketone.9. A plurality of components according to claim 1 , including at least two ...

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10-02-2022 дата публикации

POLYMERIC TUBES WITH CONTROLLED ORIENTATION

Номер: US20220040905A1
Принадлежит:

Methods for preparing oriented polymer tubes, such as biodegradable polymer tubes suitable for in vivo use, are provided herein. The disclosed methods provide alternatives to the typical extrusion/expansion methods by which oriented polymeric tubes for such uses are commonly produced. Advantageously, the disclosed methods can provide more homogeneous molecular orientation of crystallizable polymers within the tube walls, which can endow such polymeric tubes with enhanced strength (e.g., resistance to compression) and toughness. 134-. (canceled)35. A multilayered tube , comprising:at least one stretched polymeric material layer; andat least one adhesive material layer,wherein:the at least one stretched polymeric material layer exhibits at least partial molecular orientation;the at least one stretched polymeric material layer and the adhesive material layer are comprised in different layers of the tube;the at least one stretched polymeric material layer comprises at least one crystallizable biodegradable polymeric material; andthe multilayer tube has an orientation profile that is substantially consistent throughout a wall of the multilayered tube.36. The multilayered tube of claim 35 , wherein the at least one stretched polymeric material layer is obtained based at least in part on stretching at least one polymeric material in a manner that increases the at least one polymeric material in a first direction.37. The multilayered tube of claim 36 , wherein the stretching comprises a planar stretching.38. The multilayered tube of claim 36 , wherein the at least one polymeric material is stretched at least ten percent of a maximum stretch ratio corresponding to the at least one polymeric material.39. The multilayered tube of claim 36 , wherein the at least one polymeric material is stretched at least twenty percent of a maximum stretch ratio respectively corresponding to the at least one polymeric material.40. The multilayered tube of claim 35 , wherein:the at least one ...

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