12-12-2013 дата публикации
Номер: US20130330393A1
It is provided a method of treating a disorder, the method comprising implanting in a patient an implantable device including a polymer formed of fluorinated monomers and hydrocarbon monomers and another biocompatible polymer. 1. A method of treating a disorder in a patient comprising implanting in the patient an implantable device ,wherein the disorder selected from the group consisting of atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof, and [{'sub': 2', '2', '2, 'the hydrocarbon monomers are CHR═CHor CR═CHin which R is selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, short chain alkyl groups, phenyl, substituted phenyl, cyclic alkyl, heterocyclic alkyl, and heteroaryl,'}, {'sub': 2', '2', '2', '3', '3', '2', '3', '2', '2', '2, 'the fluorinated monomers are selected from the group consisting of —CH—CHF—, —CHF—CHF—, —CClF—CF—, —CF—C(CF)F—, —CHF—C(CF)F—, —CF—C(CF)H—, —CF—CR′H—, —CF—CR′F—, —CHF—CR′F—, —CH—CR′F—, and —CFH—CR′H— where R′ is independently selected from the group consisting of Cl, Br, I, methyl, ethyl, n-propyl, iosopropyl, short chain alkyl groups, phenyl, substituted phenyl, cyclic alkyl, heterocyclic, heteroaryl, fluorinated short chain alkyl groups, fluorinated phenyl, fluorinated cyclic alkyl, fluorinated heterocyclic, and combinations thereof,'}, 'the fluorinated monomers form about 25.01 mole % to about 99.99 mole % repeating units of the polymer, and', 'the hydrocarbon monomers form about 74.99 mole % to about 0.01 mole % repeating units of the polymer., 'wherein the implantable device includes a coating thereon, the biocompatible coating comprising a biocompatible polymer comprising fluorinated monomers and hydrocarbon monomers wherein'}2. The method of claim 1 , ...
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