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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 5001. Отображено 100.
21-06-2012 дата публикации

Deflectable catheter constructed to inhibit component migration

Номер: US20120157915A1
Автор: Elizabeth Younger, Gary B. La Traille, John M. Hastings
Принадлежит: St Jude Medical Atrial Fibrillation Division Inc

A catheter includes a shaft having at least one lumen. The lumen comprises a longitudinally-extending trough defined by a longitudinally-extending recess, within which a component is disposed, and a longitudinally extending open edge. The lumen further comprises a longitudinally-extending channel defined by a longitudinally-extending cavity and by the open edge of the trough. A planarity wire is disposed within the cavity and is configured to close the open edge of the trough to within a pre-defined tolerance that is less than the size of the component to retain the component in the recess.

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Номер записи: 1
26-07-2012 дата публикации

System and method for endoluminal and translumenal therapy

Номер: US20120191079A1
Автор: David C. Lundmark, Farzad Soleimani, Frederic H. Moll
Принадлежит: Hansen Medical Inc

A system for conducting a denervation of the neural plexus adjacent the renal artery of a patient comprises a first elongate member operatively coupled to a testing element, a second elongate member having a distal portion coupled to an ablative element, and a controller configured to: activate an ablative element to selectively denervate a portion of the neural plexus which is positioned adjacent the ablative element; monitor a level of a compound in blood sampled from the testing element of the first elongate member; and modulate the activation of the ablative element based at least in part upon the level of renin monitored using the testing element.

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Номер записи: 2
26-07-2012 дата публикации

Apparatus and Methods for Determining a Subject's Response to Catheter-Based Ablation Therapy Based on Spectral Mapping During Sinus Rhythm

Номер: US20120191087A1
Автор: Enrique Indalecio Pachón Mateos, José Carlos Pachón Mateos
Принадлежит: St Jude Medical Atrial Fibrillation Division Inc

Apparatus for curative ablation are provided to achieve the inactivation or destruction of fibrillar myocardium of the so-called AF nests. In addition, fibrillar myocardium may be identified and mapped by spectral analysis and phase study of the tissue during sinus rhythm. The procedure may be performed by transseptal puncture using only one catheter for ablation and mapping. The methods may be used to localize the application targets even during an arrhythmia.

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Номер записи: 3
13-09-2012 дата публикации

Radiofrequency Perforation Apparatus

Номер: US20120232546A1
Автор: Gareth Davies, Mahmood Mirza
Принадлежит: Baylis Medical Co Inc

A radiofrequency perforation apparatus for creating a channel at a target location in a body of a patient, the radiofrequency perforation apparatus comprising: a substantially tubular member defining a tubular member lumen; an end member partially positioned within the tubular member lumen at a distal end of the tubular member, the end member including an electrode; and an electrical insulator extending along the substantially tubular member.

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Номер записи: 4
25-10-2012 дата публикации

Apparatus and Method for Ablating Tissue

Номер: US20120271334A1
Автор: Benjamin Pless, David A. Gallup, Jack E. Ulstad, Jr., John E. Crowe, Jonathan L. Podmore, Matthias Vaska, Roxanne L. Richman, Scott C. Anderson, Timothy Ciciarelli
Принадлежит: Individual

A control system alters one or more characteristics of an ablating element to ablate tissue. In one aspect, the control system delivers energy nearer to the surface of the tissue by changing the frequency or power. In another aspect, the ablating element delivers focused ultrasound which is focused in at least one dimension. The ablating device may also have a number of ablating elements with different characteristics such as focal length.

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Номер записи: 5
22-11-2012 дата публикации

System and method for targeting catheter electrodes

Номер: US20120296200A1
Автор: Bruce Marx, David Johnson, Leslie Farkas, Steven Kim, Yehoshua Shachar
Принадлежит: Magnetecs Inc

A system and method is described for a catheter guidance system which allows an operator to use a mapping catheter to specify tissue target locations for the automatic guidance of a second therapeutic catheter. The operator places a mapping catheter at a desired location, and commands the catheter guidance system by either selecting a point on that catheter or one of the catheter electrode electrocardiograms. The operator may target the selected dynamic location, or tissue contact beyond that location on a specific side of the mapping catheter.

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Номер записи: 6
22-11-2012 дата публикации

Energy facilitated composition delivery

Номер: US20120296262A1
Автор: Osamu Katoh, Wayne Ogata
Принадлежит: RetroVascular Inc

A device for delivering a composition to a hollow body region is disclosed. In one aspect, the device comprises a first longitudinal member and a second longitudinal member. Both of the longitudinal members may comprise conductive electrodes. The longitudinal members are further configured to be connected to an energy source such that the conductive electrodes are configured to generate an energy field. At least one of the longitudinal members further comprises a delivery element configured to deliver at least one composition to the body region, such that the composition is delivered in a direction that is influenced by the generated energy field. In one aspect, the body region is a vessel comprising an occlusion.

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Номер записи: 7
03-01-2013 дата публикации

Contact sensor and sheath exit sensor

Номер: US20130006137A1
Автор: Jeffrey A. Schweitzer, John A. Hauck, Kenneth H. Drew
Принадлежит: St Jude Medical Atrial Fibrillation Division Inc

A system and method is provided that allows for determining the local impedance of one or more electrodes of an electrode catheter. Such local impedance may be utilized to identify the relative position of an electrode catheter to a sheath of a guiding introducer. In another arrangement, local impedance of a catheter electrode can be utilized to calibrate a catheter electrode to provide improved contact sensing.

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Номер записи: 8
21-02-2013 дата публикации

Cardiac Electrosurgery

Номер: US20130046305A1
Автор: Gareth Davies
Принадлежит: Baylis Medical Co Inc

Devices and methods are disclosed for providing access to the pericardial cavity while reducing risk of myocardial damage. The methods include maintaining the positions of a puncture device and of a portion of a parietal pericardium relative to one other while delivering energy from the puncture device to create a channel through the pericardium. Additional embodiments disclosed include delivering a pulse or pulses of energy to the parietal pericardium and attempting to advance the puncture device through the parietal pericardium between deliveries of energy pulses.

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Номер записи: 9
21-03-2013 дата публикации

Cardio mapping system and method for cardio mapping

Номер: US20130072774A1
Автор: Allan M. Greenspan
Принадлежит: Albert Einstein Healthcare Network

A method and system for determining the mechanism of cardiac arrhythmia in a patient is disclosed. The method basically entails measuring the impedance of cardiac tissue in a portion of the patient's heart using a catheter during an episode of supraventricular tachycardia to produce an iso-impedance map of that cardiac tissue on a video display and analyzing the pattern of the iso-impedance map to differentiate focal arrhythmia caused by a circumscribed region of focal firing and reentrant arrhythmia caused by a macroreentrant circuit. The method can also be used to identify regions of coherent rapidly conducting tissue e.g., Bachman's bundle or the inferoposterior pathway insertion points, to identify focal “mother rotors” throughout the left atrium that may participate in the generation and maintenance of atrial fibrillation and to identify areas of CAFE (complex atrial/fractionated electrograms) that truly reflect these mother rotors.

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Номер записи: 10
16-05-2013 дата публикации

Catheter adapted for direct tissue contact and pressure sensing

Номер: US20130123775A1
Автор: Debby Grunewald, Meir Bar-tal
Принадлежит: Biosense Webster Israel Ltd

An irrigated ablation catheter adapted for direct tissue contact has micro-elements that provide more accurate sensing of tissue, including thermal and electrical properties for temperature and impedance and intracardiac ECG measurements. A pressure sensing assembly adds the ability to measure the force at the tip of the catheter as well as to have the micro-elements for accurately sensing tissue parameters. A system uses signals from the micro-elements (impedance, temperature, and ECG signals) as well as the measure of force or pressure at the tip electrode order to provide the operator with a means to control lesion depth, size, transmurality and to ablate tissue until successful treatment of an arrhythmia is achieved.

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Номер записи: 11
23-05-2013 дата публикации

Recanalizing occluded vessels using radiofrequency energy

Номер: US20130131513A1
Автор: Osamu Katoh, Wayne Ogata
Принадлежит: RetroVascular Inc

A method and systems for treating chronic total occlusions, particularly those that are difficult to treat, is disclosed. In this approach, recanalizing the CTO is achieved using a combined antegrade and retrograde approach. The proximal end of the occlusion is penetrated using an antegrade wire, using a traditional approach. Using collateral vessels, the distal end of the occlusion is crossed in a retrograde fashion. By appropriately maneuvering each member and applying radiofrequency energy between the proximal and distal ends of the occlusion, a continuous channel is created.

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Номер записи: 12
23-05-2013 дата публикации

Sensing zone for spatially relevant electrical information

Номер: US20130131529A1
Автор: Brian P. GEORGE, Charulatha Ramanathan, Harold Wodlinger, Jonathan D. SMALL, Lalita BHETWAL, Maria Strom, Ping Jia
Принадлежит: Cardioinsight Technologies Inc

Systems and methods are disclosed to determine one or more sensing zones on a body surface for electrocardiographic mapping of a region of interest associated with the heart. The sensing zone can be utilized to facilitate acquisition, processing and mapping of electrical activity for the corresponding region of interest. In other examples, an application-specific arrangement of electrodes can also be provided based on the sensing zone that is determined for the region of interest.

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Номер записи: 13
13-06-2013 дата публикации

Catheter balloon methods and apparatus employing sensing elements

Номер: US20130150693A1
Автор: Bassel de Graff, Cliff Liu, Kevin Dowling, Lauren Klinker, Robert D'Angelo, Roozbeh Ghaffari, Stephen P. Lee, Yung-Yu Hsu
Принадлежит: Individual

An apparatus for medical diagnosis and/or treatment is provides. The apparatus includes a flexible substrate forming an inflatable body and a plurality of sensing elements disposed on the flexible substrate. The plurality of sensing elements are disposed about the inflatable body such that the sensing elements are disposed at areas of minimal curvature of the inflatable body in a deflated state.

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Номер записи: 14
04-07-2013 дата публикации

Neural Monitor-Based Dynamic Haptics

Номер: US20130172902A1
Автор: Chris Alan LIGHTCAP, Hyosig Kang
Принадлежит: Mako Surgical Corp

A computer-assisted surgery system may have a robotic arm including a surgical tool and a processor communicatively connected to the robotic arm. The processor may be configured to receive, from a neural monitor, a signal indicative of a distance between the surgical tool and a portion of a patient's anatomy including nervous tissue. The processor may be further configured to generate a command for altering a degree to which the robotic arm resists movement based on the signal received from the neural monitor; and send the command to the robotic arm.

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Номер записи: 15
11-07-2013 дата публикации

Enhanced medical device for use in bodily cavities, for example an atrium

Номер: US20130178851A1
Автор: Aldo Antonio Salvestro, Ashkan Sardari, Douglas Goertzen, Fernando Lopes, Jorge Jaramillo, Peter Hawes, Saar Moisa
Принадлежит: Kardium Inc

Systems, methods, and devices allow intravascular or percutaneous mapping, orientation and/or ablation, in bodily cavities or lumens. A device includes elongate members, moveable between an unexpanded configuration and an expanded or fanned configuration. The elongate members form a stack in the unexpanded configuration to fit through a catheter sheath. The elongate members follow respective arcuate or curvilinear paths as advanced from the sheath into the bent or coiled stack configuration, adopting volute, scroll or rho shapes, and may be nested. The elongated members are fanned or radially spaced circumferentially with respect to one another into the expanded or fanned configuration. Transducer elements carried by elongate members sense various physiological characteristics of or proximate tissue, and/or may apply energy to or proximate tissue. The elongate members are rotatable in groups or as a group in the expanded configuration. The device is retractable.

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Номер записи: 16
25-07-2013 дата публикации

Devices for thermally-induced hepatic neuromodulation

Номер: US20130190748A1
Автор: Bobak Robert Azamian, Jonathan Allen Coe, Scott Bradley Vafai
Принадлежит: Metavention Inc

According to some embodiments, a method of treating a subject having diabetes or symptoms associated with diabetes is provided. The method includes delivering a neuromodulation catheter within a vessel (e.g., hepatic artery) having surrounding nerves that innervate the liver (e.g., sympathetic nerves of the hepatic plexus). The method may also include modulating (e.g., disrupting, ablating, stimulating) the nerves by mechanical compression, energy delivery, or fluid delivery.

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Номер записи: 17
12-09-2013 дата публикации

Mapping probe assembly with skived tube body frame

Номер: US20130237985A1
Автор: Isaac J. Kim, Josef V. Koblish
Принадлежит: Boston Scientific Scimed Inc

An embodiment of a mapping probe assembly includes a body frame with a lumen therein. The body frame includes a catheter shaft region, a loop section and a transition region between the catheter shaft region and a loop section. A plurality of mapping electrodes are attached around the loop section. Electrical conductors extend through the lumen of the body frame to the mapping electrodes. In some embodiments, the loop section is skived, where a portion of the body frame is removed toward the interior of the loop section. The loop section has a generally planar loop, and further has a loop center. In some embodiments, the catheter shaft has an alignment generally perpendicular to the loop section where the alignment of the catheter shaft is along a line that intersects the planar loop proximate to the loop center.

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Номер записи: 18
17-10-2013 дата публикации

Haptic system for balloon tipped catheter interventions

Номер: US20130274712A1
Автор: Stuart O. Schecter
Принадлежит: Individual

Embodiments of this invention include hand-held handles and systems for balloon-tipped catheter interventions that enable a user to appreciate a combination of palpable sensations as though his or her hand is actual anatomic tissue in situ in real time. The system may include a haptic handle coupled to the proximal end of the catheter where the haptic handle includes a balloon-shaped haptic interface that exhibits geometric characteristics reflecting an anatomy of the interventional balloon and provides tangible sensations representative of tissues surrounding the interventional balloon. Multiple sensors and actuators may be used to create a non-virtual, transparent experience communicated to a user with a three dimensional, volumetric haptic display. In one embodiment, the sensors are positioned about or within an inflatable balloon positioned at the distal aspect of an inserted catheter used to treat cardiac and vascular diseases such as coronary or peripheral vascular occlusion and ablation of cardiac tissue.

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Номер записи: 19
31-10-2013 дата публикации

Switched safety protection circuit for an aimd system during exposure to high power electromagnetic fields

Номер: US20130289666A1
Автор: Christopher Michael Williams, Holly Noelle Moschiano, Robert A. Stevenson, Robert Shawn Johnson, Scott Brainard, Warren S. Dabney
Принадлежит: Greatbatch Ltd

An energy management system that facilitates the transfer of high frequency energy induced on an implanted lead or a leadwire includes an energy dissipating surface associated with the implanted lead or the leadwire, a diversion or diverter circuit associated with the energy dissipating surface, and at least one switch disposed between the diversion circuit and the AIMD electronics for diverting energy in the implanted lead or the leadwire through the diversion circuit to the energy dissipating surface. The switch may comprise a single or multi-pole double or single throw switch. The diversion circuit may be either a high pass filter or a low pass filter.

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Номер записи: 20
14-11-2013 дата публикации

Enhanced medical device for use in bodily cavities, for example an atrium

Номер: US20130304065A1
Автор: Aldo Antonio Salvestro, Ashkan Sardari, Douglas Wayne GOERTZEN, Fernando Luis De Souza Lopes, Jorge Jaramillo, Peter Josiah Hawes, Saar Moisa
Принадлежит: Kardium Inc

Systems, methods, and devices allow intravascular or percutaneous mapping, orientation or ablation, or combinations thereof in bodily cavities or lumens. A device includes a plurality of elongate members which are moveable between an unexpanded configuration, a bent or coiled stack configuration and an expanded or fanned configuration. The elongate members form a stack arrangement in the unexpanded configuration to fit through a catheter sheath. The elongate members follow respective arcuate or curvilinear paths as advanced from the sheath into the bent or coiled stack configuration, adopting volute, scroll or rho shapes, and may be nested. The elongated members are fanned or radially spaced circumferentially with respect to one another into the expanded or fanned configuration. Transducers carried by elongate members may sense various physiological characteristics of or proximate tissue, for instance temperature, and/or may apply energy to or proximate tissue, for example to perform ablation. The device is retractable.

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Номер записи: 21
02-01-2014 дата публикации

Real time assessment of ablation from electrocardiogram signals

Номер: US20140005664A1
Автор: Assaf Govari, Athanassios Papaioannou
Принадлежит: Biosense Webster Israel Ltd

An apparatus includes an intra-body probe and a processor. The intra-body probe includes an electrode, which is configured to contact tissue in a heart. The processor is configured to receive an electrical signal from the electrode, to distinguish a local component, due to the tissue with which the electrode is in contact, in the electrical signal from a remote-field contribution to the signal, and to control a therapeutic procedure applied to the tissue responsively to the distinguished local component.

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Номер записи: 22
16-01-2014 дата публикации

Devices and Systems for Carotid Body Ablation

Номер: US20140018788A1
Автор: Charles Lennox, Howard Levin, Kenneth M. Martin, Marat FUDIM, Mark Gelfand, Mark Leung, Martin M. GRASSE, Marwan Abboud, Michael Brick MARKHAM, Miriam H. Taimisto, Robert Brommer, Scott H. West, Zoar Jacob ENGELMAN
Принадлежит: Cibiem Inc

Methods and endovascular catheters for assessing, and treating patients having sympathetically mediated disease, involving augmented peripheral chemoreflex and heightened sympathetic tone by reducing chemosensor input to the nervous system via transmural carotid body ablation.

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Номер записи: 23
23-01-2014 дата публикации

Ablation catheter with flexible tip

Номер: US20140025068A1
Автор: Alan de la Rama, Carlo Pappone, Cary Hata, Jared A. Shimizu, Peter Chen
Принадлежит: St Jude Medical Atrial Fibrillation Division Inc

A flexible tip electrode for an ablation catheter is disclosed. The catheter includes a catheter body and a hollow elongate tip electrode disposed at a distal end of the catheter body. The electrode includes a sidewall provided with one or more elongate gaps extending therethrough. The one or more elongate gaps providing flexibility in the sidewall for bending movement of the tip electrode relative to a longitudinal axis of the catheter body.

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Номер записи: 24
06-02-2014 дата публикации

Systems, Methods and Devices Having Stretchable Integrated Circuitry for Sensing and Delivering Therapy

Номер: US20140039290A1
Автор: Bassel de Graff, Roozbeh Ghaffari, William J. Arora
Принадлежит: Individual

System, devices and methods are presented that integrate stretchable or flexible circuitry, including arrays of active devices for enhanced sensing, diagnostic, and therapeutic capabilities. The invention enables conformal sensing contact with tissues of interest, such as the inner wall of a lumen, a the brain, or the surface of the heart. Such direct, conformal contact increases accuracy of measurement and delivery of therapy. Further, the invention enables the incorporation of both sensing and therapeutic devices on the same substrate allowing for faster treatment of diseased tissue and fewer devices to perform the same procedure.

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Номер записи: 25
20-02-2014 дата публикации

Modulation of nerves that innervate the liver

Номер: US20140052121A1
Автор: Bobak Robert Azamian, Jonathan Allen Coe, Scott Bradley Vafai
Принадлежит: Metavention Inc

According to some embodiments, a method of treating a subject having diabetes or symptoms associated with diabetes is provided. The method includes delivering a neuromodulation catheter within a vessel (e.g., hepatic artery) having surrounding nerves that innervate the liver (e.g., sympathetic nerves of the hepatic plexus). The method may also include modulating (e.g., disrupting, ablating, stimulating) the nerves by mechanical compression, energy delivery, or fluid delivery.

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Номер записи: 26
06-03-2014 дата публикации

Neuromodulation methods using balloon catheter

Номер: US20140066924A1
Автор: Bobak Robert Azamian, Jonathan Allen Coe, Scott Bradley Vafai
Принадлежит: Metavention Inc

According to some embodiments, a method of treating a subject having diabetes or symptoms associated with diabetes is provided. The method includes delivering a neuromodulation catheter within a vessel (e.g., hepatic artery) having surrounding nerves that innervate the liver (e.g., sympathetic nerves of the hepatic plexus). The method may also include modulating (e.g., disrupting, ablating, stimulating) the nerves by mechanical compression, energy delivery, or fluid delivery.

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Номер записи: 27
13-03-2014 дата публикации

Band stop filter comprising an inductive component disposed in a lead wire in series with an electrode

Номер: US20140074211A1
Автор: Henry R. Halperin, Robert A. Stevenson
Принадлежит: Greatbatch Ltd

A band stop filter is provided for a lead wire of an active medical device (AMD). The band stop filter includes a capacitor in parallel with an inductor. The parallel capacitor and inductor are placed in series with the lead wire of the AMD, wherein values of capacitance and inductance are selected such that the band stop filter is resonant at a selected frequency. The Q of the inductor may be relatively maximized and the Q of the capacitor may be relatively minimized to reduce the overall Q of the band stop filter to attenuate current flow through the lead wire along a range of selected frequencies. In a preferred form, the band stop filter is integrated into a TIP and/or RING electrode for an active implantable medical device.

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Номер записи: 28
20-03-2014 дата публикации

Nearfield ultrasound echography mapping

Номер: US20140081262A1
Автор: David L. Mcgee, Josef V. Koblish
Принадлежит: Boston Scientific Scimed Inc

Various embodiments concern delivering an ablation therapy to different areas of the cardiac tissue and, for each of the areas, sensing an ultrasound signal with at least one ultrasound sensor, the ultrasound signal responsive to the ultrasound energy reflected from the area of cardiac tissue. Such embodiments can further include for each of the plurality of different areas of the cardiac tissue, associating with each area an indication of the degree to which the area of cardiac tissue was lesioned by the delivery of the ablation therapy based on the ultrasound signal and representing a map of the different areas on a display. A user input can select one of the different areas and the indication associated with the selected one area can be represented on the map.

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Номер записи: 29
06-01-2022 дата публикации

Systems and Methods for Percutaneous Division of Fibrous Structures

Номер: US20220000513A1
Автор: Brian J. Deguzman, Lishan Aklog
Принадлежит: Pavmed Inc

A device for dividing a fibrous structure comprising a catheter; an expandable member positioned near a distal end of the catheter and in fluid communication with a lumen of the catheter; and a cutting element situated on an outer surface of the expandable member. A method for dividing a fibrous structure comprising positioning, proximate the fibrous structure, an expandable member having a cutting element situated thereon; expanding the expandable member outwards to tension the fibrous structure across the cutting element; and activating the cutting element to weaken or cut the fibrous structure. A method for treating carpal tunnel syndrome comprising inserting a needle into the carpal tunnel; directing a guidewire to a position proximate the transverse carpal ligament; advancing, along the guidewire, a device having an expandable member and a cutting element; positioning the cutting element; tensioning the ligament across the cutting element; and weakening or cutting the ligament.

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Номер записи: 30
06-01-2022 дата публикации

Electrosurgical unit and system

Номер: US20220000552A1
Автор: David HUBELBANK, Jesse Smith, John Gearheart, Vini Podany
Принадлежит: MEDTRONIC ADVANCED ENERGY LLC

Systems, such as an electrosurgical unit, and method for use with an active electrode and a plurality of return electrodes are disclosure. An electrosurgical treatment is provided to tissue via the active electrode at a treatment site and a first return electrode of the plurality of return electrodes at the treatment site. An impedance measurement is received or determined of an impedance in the tissue between the active electrode at the treatment site and a second return electrode of the plurality of return electrodes at a site remote from the treatment site.

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Номер записи: 31
02-01-2020 дата публикации

CUSTOMIZABLE INTERFACE SYSTEM FOR INVASIVE CARDIOLOGY AND ELECTROPHYSIOLOGY

Номер: US20200000358A1
Автор: Mabini Daniel P., Schmit Rodger F., Schneidewend Daniel R., Stiemke Timothy P., Warner Adrian F.
Принадлежит: GENERAL ELECTRIC COMPANY

A physiological data acquisition system includes at least one interface module and a base unit configured to communicatively connect to the at least one interface module to receive the physiological signals recorded by a catheter. Each interface module is formed by mating at least a first one of the two or more different personality modules to a dock. The dock has a multi-modal connection port configured to directly connect to a dock connector of any one of the two or more different personality modules so as to receive physiological signals therefrom. The first personality module includes a first catheter connector configured to receive a connection end of the catheter so as to receive physiological signals therefrom, and a first dock connector configured to connect to the multi-modal connection port of the dock so as to provide the physiological signals thereto. 1. A physiological data acquisition system comprising: a dock configured to mate with two or more different personality modules, the dock including a multi-modal connection port configured to directly connect to a dock connector of any one of the two or more different personality modules so as to receive physiological signals therefrom;', a first catheter connector configured to receive a connection end of a catheter so as to receive physiological signals therefrom;', 'a first dock connector configured to connect to the multi-modal connection port of the dock so as to provide the physiological signals thereto; and, 'a first one of the two or more different personality modules including], 'at least one interface module, wherein each interface module comprisesa base unit configured to communicatively connect to the at least one interface module to receive the physiological signals therefrom.2. The physiological data acquisition system of claim 1 , wherein the dock is housed in a dock housing and the personality module is housed in a personality module housing claim 1 , wherein the dock housing and the ...

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Номер записи: 32
03-01-2019 дата публикации

Circuits And Methods For Electrosurgical Unit Signal Detection

Номер: US20190000393A1
Автор: Freeman Daniel K., Gatzke Ronald
Принадлежит: Dragerwerk AG & Co. KgaA

Circuits are provided for detecting an electrosurgical unit signal. An example circuit includes: a filter configured to process a floating ground signal associated with measuring a bio potential signal of a patient, and a detector configured to output a sensing signal based at least in part on the floating grounding and the Earth ground for detecting an electrosurgical unit signal. 1. A circuit for detecting an electrosurgical unit signal , the circuit comprising:a filter configured to process a floating ground signal associated with measuring a bio-potential signal of a patient; anda detector configured to output a sensing signal based at least in part on the floating ground signal and an Earth ground for detecting an electrosurgical unit signal.2. The circuit of claim 1 , wherein the filter includes:a capacitor; anda resistor including a first resistor terminal and a second resistor terminal, the first resistor terminal being electrically connected to the capacitor, the second resistor terminal being biased to the Earth ground.3. The circuit of claim 1 , wherein:the capacitor includes a first capacitor terminal and a second capacitor terminal;the first capacitor terminal is configured to receive the floating ground signal; andthe second capacitor terminal is electrically connected to the first resistor terminal.4. The circuit of claim 1 , wherein the detector includes:a diode including an anode terminal and a cathode terminal, the anode terminal being electrically connected to the filter;a capacitor including a first capacitor terminal and a second capacitor terminal, the first capacitor terminal being electrically connected to the cathode terminal, the second capacitor terminal being biased to the Earth ground; anda resistor including a first resistor terminal and a second resistor terminal, the first resistor terminal being electrically connected to the first capacitor terminal, the second resistor terminal being biased to the Earth ground.5. The circuit of ...

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Номер записи: 33
07-01-2021 дата публикации

System, method and computer-accessible medium for in-vivo tissue ablation and/or damage

Номер: US20210000527A1
Автор: Govindarajan Srimathveeravalli, Stephen Barnett SOLOMON
Принадлежит: Memorial Sloan Kettering Cancer Center

Systems, methods and computer-accessible mediums can be provided that can establish particular parameters for electric pulses based on a characteristic(s) of the tissue(s), and control an application of the electric pulses to tissue(s) for a plurality of automatically controlled and separated time periods to ablate the tissue(s) through mediation of membrane potential and through inducing the cells through a plurality of charge-discharge cycles such that an electroporation of a majority of the tissue(s) is prevented or reduced.

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Номер записи: 34
03-01-2019 дата публикации

Neural monitor-based dynamic haptics

Номер: US20190000553A1
Автор: Arthur E. Quaid, III, Chris Alan LIGHTCAP, Hyosig Kang, Rony Abovitz
Принадлежит: Mako Surgical Corp

A surgical system includes a robotic device, and a surgical tool coupled to the robotic device and comprising a distal end. The system further includes a neural monitor configured to generate an electrical signal and apply the electrical signal to the distal end of the surgical tool, wherein the electrical signal causes innervation of a first portion of a patient's anatomy which generates an electromyographic signal, and a sensor configured to measure the electromyographic signal. The neural monitor is configured to determine a distance between the distal end of the surgical tool and a portion of nervous tissue based on the electrical signal and the electromyographic signal, and cause feedback to be provided to a user based on the distance.

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Номер записи: 35
04-01-2018 дата публикации

ABLATION CATHETER WITH ELECTRODES

Номер: US20180000541A1
Автор: Chen Peter, de la Rama Alan, Hata Cary
Принадлежит:

A catheter configured to deliver therapeutic energy to a tissue can include can include an elongate shaft extending along a shaft longitudinal axis and comprising a shaft proximal end and a shaft distal end. The catheter can include a flexible tip assembly comprising a tip assembly outer surface, wherein the flexible tip assembly is connected to the shaft distal end and is configured to deliver therapeutic energy to the tissue, and wherein the flexible tip assembly further includes. The flexible tip assembly can include an insulative layer comprising an insulative layer outer surface, wherein the insulative layer is disposed on the tip assembly outer surface and a mapping electrode disposed on the insulative layer outer surface. 1. A catheter configured to deliver therapeutic energy to a tissue , comprising:an elongate shaft extending along a shaft longitudinal axis and comprising a shaft proximal end and a shaft distal end; an insulative layer comprising an insulative layer outer surface, wherein the insulative layer is disposed on the tip assembly outer surface; and', 'a mapping electrode disposed on the insulative layer outer surface., 'a flexible tip assembly comprising a tip assembly outer surface, wherein the flexible tip assembly is connected to the shaft distal end and is configured to deliver therapeutic energy to the tissue, and wherein the flexible tip assembly further includes2. The catheter of claim 1 , wherein the insulative layer is disposed in a channel formed in the tip assembly outer surface.3. The catheter of claim 2 , wherein the flexible tip assembly comprises a tip assembly longitudinal axis claim 2 , and wherein the insulative layer is elongated and extends along a longitudinal axis of the flexible tip assembly.4. The catheter of claim 2 , wherein the mapping electrode is one of a plurality of mapping electrodes disposed on the insulative layer outer surface.5. The catheter of claim 4 , wherein the plurality of mapping electrodes are ...

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Номер записи: 36
01-01-2015 дата публикации

Method and Devices for Treating Atrial Fibrillation by Mass Ablation

Номер: US20150005694A1
Автор: David E. Francischelli, James R. Skarda, Mark T. Stewart
Принадлежит: MEDTRONIC INC

Apparatus and method for ablating target tissue including a non-linear area of tissue in the left atrium of a patient. The method can include selecting an ablation apparatus having an ablator with a tissue engagement section, penetrating a chest cavity of the patient, and identifying the target tissue. The method can also include positioning the ablation apparatus adjacent to the target tissue so that the tissue engagement section can transfer ablation energy to the target tissue. The method can further include energizing the tissue engagement section with ablation energy in order to create a footprint on the non-linear area of tissue in the left atrium and to reduce an overall mass of excitable tissue in the left atrium.

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Номер записи: 37
20-01-2022 дата публикации

Visualization and recordation system interface with virtual ground for biomedical system and methods

Номер: US20220015658A1
Автор: Andres Claudio Altmann, Israel Zilberman, Vadim Gliner
Принадлежит: Biosense Webster Israel Ltd

Methods, apparatus, and systems for medical procedures are disclosed herein. For example, a plurality of analog sensor signals and an analog reference signal are received by an analog-to-digital converter to produce respective digitized versions of the analog sensor signals. The respective digitized versions of the analog sensor signals are digital filtered to produce respective filtered digitized versions of the analog sensor signals. The filtered digitized versions of the analog sensor signals are output to a visualization system to provide real time display thereof. The filtered digitized versions of the analog sensor signals are communicated to a digital-to-analog converter to produce an analog version of the filtered digitized versions of the analog sensor signals. The analog version of the filtered digitized versions of the analog sensor signals along with the analog reference signal are output to a recordation system to provide supplemental processing and storage thereof.

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Номер записи: 38
12-01-2017 дата публикации

Electrical-signal-based electrode-tissue contact detection

Номер: US20170007157A1
Автор: Assaf Israel Pele LEON, Yehuda Zadok, Yossi Gross
Принадлежит: Pythagoras Medical Ltd

A method includes disposing a pair of current-application electrodes in or on a body, including disposing an intrarenal current-application electrode of the pair in a renal artery. Two or more sensing electrodes are disposed in or on the body, including disposing one of the sensing electrodes on en external surface of skin. Control circuitry is activated to (a) apply an electrical current between the pair of current-application electrodes, (b) while applying the electrical current, sense an electrical signal between the sensing electrodes, including the sensing electrode disposed on the external surface of the skin, and (c) based on the electrical signal, ascertain a level of contact between the intrarenal current-application electrode and a wall of the renal artery. In response to the level of contact being less than a threshold level of contact, a disposition of the intrarenal current-application electrode in the renal artery is adjusted.

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Номер записи: 39
14-01-2016 дата публикации

Mapping ablation catheter

Номер: US20160008060A1
Автор: Young Hoon Kim
Принадлежит: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION

A mapping ablation catheter is provided comprising: a catheter conduit having a hollow inner space in which a guide member is disposed; a monitoring electrode unit arranged to surround the outer circumferential surface of the distal portion of the catheter conduit and perform a mapping on the lesion region by being in side-contact with a cardiac organ; an ablation electrode unit arranged to be spaced apart from the monitoring electrode unit and surround the outer circumferential surface of the distal portion of the catheter conduit and which removes the lesion region; a plurality of liquid discharge holes arranged on the outer circumferential surface of the ablation electrode; a current application unit which applies current to the monitoring electrode unit and the ablation electrode unit; and a liquid supply unit having a liquid supply tube, one end of the liquid-supply tube connected to the liquid discharge holes in the catheter conduit.

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Номер записи: 40
10-01-2019 дата публикации

Electrosurgical Pericaridial Puncture

Номер: US20190008588A1
Автор: Davies Gareth
Принадлежит:

Devices and methods for providing access to the pericardial cavity while reducing risk of myocardial damage. One method includes using an apparatus to apply pressure to a parietal pericardium, retracting the apparatus, and puncturing the parietal pericardium by delivering electrical energy using a puncture device. Another method includes moving a portion of parietal pericardium away from a surface of myocardium of the heart and puncturing the parietal pericardium by delivering electrical energy using a puncture device. The methods may include a step of confirming that the puncture device is at least partially within the parietal cavity by injecting or aspirating fluid through a lumen in the puncture device or measuring the pressure or electrical impedance at the distal end of the puncture device. 121.-. (canceled)22. A method of accessing a pericardial cavity of a heart comprising:a. using an apparatus to apply pressure to a parietal pericardium;b. retracting the apparatus; andc. puncturing the parietal pericardium by delivering electrical energy using a puncture device.23. The method of claim 22 , further comprising the step of advancing the puncture device through the apparatus.24. The method of claim 22 , further comprising a step of confirming that the puncture device is at least partially within the pericardial cavity.25. The method of claim 24 , wherein the step of confirming that the puncture device is at least partially within the pericardial cavity comprises injecting a contrast fluid into the pericardial cavity through a lumen of the puncture device.26. The method of claim 24 , wherein the step of confirming that the puncture device is at least partially within the pericardial cavity comprises aspirating fluid from the pericardial cavity through a lumen of the puncture device.27. The method of claim 24 , wherein the step of confirming that the puncture device is at least partially within the pericardial cavity comprises measuring electrical impedance at a ...

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Номер записи: 41
03-02-2022 дата публикации

Medical-mapping device

Номер: US20220031216A1
Автор: Linus Leung
Принадлежит: Baylis Medical Co Inc

A medical-mapping device includes an elongated electrode-support assembly having spaced-apart electrodes configured to be maneuverable, at least in part, into, and along, a confined space of a patient. The spaced-apart electrodes are configured to be selectively movable between a storage position and a deployment position.

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Номер записи: 42
03-02-2022 дата публикации

Controlled and precise treatment of cardiac tissues

Номер: US20220031378A1
Автор: Landy Toth, Robert S. Schwartz
Принадлежит: Individual

Compositions, systems, devices, and methods for performing precise chemical treatment of tissues are disclosed. Systems, devices, and methods for administering a chemical agent to one or more a precise regions within a tissue mass are disclosed. Compositions, systems, devices, and methods for treating targeted regions within a tissue mass are disclosed. Systems, devices, and methods for identifying, localizing, monitoring neural traffic in the vicinity of, quantifying neural traffic in the vicinity of, and mapping neural traffic near targeted regions within a tissue mass are disclosed.

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Номер записи: 43
03-02-2022 дата публикации

Cautious irreversible-electroporation (ire) protocol for avoiding bubble generation

Номер: US20220031387A1
Автор: Assaf Govari
Принадлежит: Biosense Webster Israel Ltd

An irreversible electroporation (IRE) includes setting an initial IRE protocol for applying IRE pulses by electrodes of a catheter placed in contact with tissue in an organ. A notification is issued to a user upon determining that the initial IRE protocol is expected to cause bubbles in blood. In response to the notification, user input is received from the user, that selects between the initial IRE protocol and an alternative protocol that is not expected to cause the bubbles. The IRE pulses are applied according to the initial IRE protocol or the alternative IRE protocol, depending on the user input.

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Номер записи: 44
18-01-2018 дата публикации

DIAPHRAGM PUMPS FOR MEDICAL APPLICATIONS

Номер: US20180014878A1
Автор: Algawi Yehuda, Govari Assaf
Принадлежит:

Apparatus and methods described include a pump, which includes a piston, a diaphragm coupled to the piston and defining a wall of a fluid chamber, and a snail cam. The snail cam is configured to, by rotating, alternatingly (i) pump fluid from the fluid chamber, and (ii) draw fluid into the fluid chamber, by driving the piston to move the diaphragm. Other embodiments are also described. 1. A pump , comprising:a piston;a diaphragm coupled to the piston and defining a wall of a fluid chamber; anda snail cam configured to, by rotating, alternatingly (i) pump fluid from the fluid chamber, and (ii) draw fluid into the fluid chamber, by driving the piston to move the diaphragm.2. The pump according to claim 1 , wherein the snail cam is configured to claim 1 , when rotating at a constant speed claim 1 , alternatingly (i) pump fluid from the fluid chamber at a first rate claim 1 , and (ii) draw fluid into the fluid chamber at a second rate that is greater than the first rate.3. The pump according to claim 1 , wherein the snail cam is configured to claim 1 , when rotating at a constant speed claim 1 , during each rotational cycle of the snail cam claim 1 , (i) pump fluid from the fluid chamber for a first amount of time claim 1 , and (ii) draw fluid into the fluid chamber for a second amount of time that is less than the first amount of time.4. The pump according to claim 3 , wherein a ratio of the first amount of time to the second amount of time is at least 4:1.5. The pump according to claim 1 , wherein the snail cam is shaped to define a tooth having a slope of between 50 and 80 degrees.6. The pump according to claim 1 , wherein the snail cam is shaped to define a plurality of teeth.7. The pump according to claim 1 , wherein claim 1 , over a majority of a circumference of the snail cam claim 1 , a rate of increase of a radius of the snail cam is constant.8. Apparatus claim 1 , comprising:a piston;a diaphragm coupled to the piston and defining a wall of a fluid chamber;a ...

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Номер записи: 45
18-01-2018 дата публикации

SYSTEM AND METHOD FOR PERFORMING RENAL DENERVATION VERIFICATION

Номер: US20180014882A1
Автор: Bornzin Gene A., Cholette Martin, Dulak Gary R., Fain Eric S., Poore John W.
Принадлежит:

A renal denervation feedback method is described that performs a baseline measurement of renal nerve plexus electrical activity at a renal vessel; denervates at least some tissue proximate the renal vessel after performing the baseline measurement; performs a post-denervation measurement of renal nerve plexus electrical activity at the renal vessel, after the denervating; and assesses denervation of the renal vessel based on a comparison of the baseline measurement and the post-denervation measurement of renal nerve plexus electrical activity at the renal vessel. 139-. (canceled)40. A renal denervation feedback method comprising:performing a baseline measurement of intrinsic renal nerve plexus electrical activity at a renal vessel by monitoring compound action potentials including baseline afferent and efferent signals;denervating at least some tissue at a denervation location proximate the renal vessel after performing the baseline measurement;performing a post-denervation measurement of intrinsic renal nerve plexus electrical activity at a measurement location on a distal side of the denervation location by monitoring post-denervation compound action potentials, after the denervating; anddetermining the denervation is complete when the post-denervation compound action potentials include solely afferent signals.41. The renal denervation feedback method of claim 40 , further comprising claim 40 , if the denervation is not complete:repeating the steps of denervating and performing a post-denervation measurement until the post-denervation compound action potentials are solely afferent signals.42. The renal denervation feedback method of claim 40 , wherein performing the baseline measurement of renal nerve plexus electrical activity comprises:counting a number of baseline afferent spikes each representing an afferent compound action potential that exceeds a preset threshold during a specified period of time; andcounting a number of baseline efferent spikes each ...

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Номер записи: 46
18-01-2018 дата публикации

CATHETERS AND METHODS FOR INTRACARDIAC ELECTRICAL MAPPING

Номер: US20180014883A1
Автор: GROVES Regina E., Knight Joseph Allen, LASKE Timothy G.
Принадлежит:

A method and system capable of identifying ectopic foci, rotors, or conduction pathways involved in reentrant arrhythmias within cardiac tissue, and then treating identified ectopic foci, rotors, and/or pathways with either lethal or sub-lethal temperatures. The system includes a medical device having one or more mapping elements and one or more treatment elements, and a computer programmable to identify ectopic foci and rotors based at least in part on signals received from the one or more mapping elements at one or more locations. 1. A method of locating and treating a source or pathway of electrical conduction within cardiac tissue , the method comprising:(a) positioning one or more mapping elements affixed to a distal end of medical device in contact with cardiac tissue at a first position, the medical device being in communication with a control system including a computer having a display and programmable to execute algorithms, the cardiac tissue being composed of cells;(b) executing computer algorithms to determine directional and morphological features of the electrical conduction of interest based at least in part on signals received by the computer from the one or more mapping elements at the first position;(c) displaying on the computer display a suggested second position at which the one or more mapping elements should be placed in contact with the cardiac tissue;(d) repositioning the one or more mapping elements at the second position;(e) executing computer algorithms to determine directional and morphological features of the electrical conduction of interest based at least in part on signals received by the computer from the one or more mapping elements at the second position;(f) repeating steps (a)-(e) until a source or pathway of the electrical conduction of interest is located; and(g) activating one or more treatment elements in contact with the cardiac tissue cells to treat the cells at a non-lethal temperature and disrupt the source or pathway of ...

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Номер записи: 47
17-01-2019 дата публикации

APPARATUS FOR EFFECTIVE ABLATION AND NERVE SENSING ASSOCIATED WITH DENERVATION

Номер: US20190015002A1
Автор: Almany Steven, FISCHELL DAVID R., FISCHELL TIM A., Ghazarossian Vartan, John Michael Sasha
Принадлежит:

An intravascular catheter for nerve activity ablation and/or sensing includes one or more needles advanced through supported guide tubes (needle guiding elements) which expand to contact the interior surface of the wall of the renal artery or other vessel of a human body allowing the needles to be advanced though the vessel wall into the extra-luminal tissue including the media, adventitia and periadvential space. The catheter also includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened needles are advanced to penetrate into the vessel wall. Electrodes near the distal ends of the needles allow sensing of nerve activity before and after attempted renal denervation. In a combination embodiment ablative energy or fluid is delivered from the needles in or near the adventitia to ablate nerves outside of the media while sparing nerves within the media. 1. A catheter for sensing the activity from nerves outside of the lumen of a target vessel of a human body comprising:a catheter body having a distal end for insertion into a patient, a proximal end for controlling the movement of at least one needle, and a central axis extending in a longitudinal direction;a connector configured to connect to external electronic equipment outside of a proximal end of the catheter, said equipment having a sensing subsystem configured for sensing local nerve activity within a patient, and configured to be connected to at least one additional electrode in electrical contact with the patient;at least one needle guiding element adapted to expand outwardly from the catheter body toward the interior wall of the target vessel;at least one needle, the needle having at least one distal electrode, the needle adapted to be advanced outwardly, guided by the at least one needle guiding element to penetrate and advance through the interior wall of the ...

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Номер записи: 48
17-01-2019 дата публикации

MEDICAL DEVICE WITH FORWARD AND SIDEWARD ABLATION MONITORING ULTRASOUND TRANSDUCERS

Номер: US20190015072A1
Автор: Deladi Szabolcs, RADEMAKERS Antonius Johannes Josephus, VAN DER VLEUTEN CORNELIUS ANTONIUS NICOLAAS MARIA
Принадлежит:

The invention relates to ultrasound imaging method and apparatus suitable for minimally invasive ultrasound diagnostic devices in cardiac ablation monitoring and in tumor ablation monitoring. The present invention proposes an assembly of forward and side-facing transducers and a system of embedded forward and side-facing transducers in apertures on surfaces of the assembly. This provides control of the acoustic properties of the transducer and improved ablation monitoring when the assembly is incorporated in a medical device. 115-. (canceled)16. A combined ablation and ultrasound imaging catheter for insertion within a body , the catheter having a catheter tip comprising:an ablation cap having a distal-facing aperture and a plurality of lateral-facing apertures formed through the ablation cap, wherein the plurality of lateral-facing apertures are located proximal of the distal facing aperture, and are arrayed around a circumference of the ablation cap;an ultrasound transducer system fixed within the ablation cap and having:a first ultrasound transducer element configured to follow an ablation procedure in a first direction through the distal-facing aperture of the ablation cap, the first direction orientated primarily distally away from the catheter tip;a plurality of second ultrasound transducer elements located proximal to the first ultrasound transducer element, the plurality of second ultrasound transducer elements arrayed about the circumference of the ablation cap and configured to follow the ablation procedure through the plurality of lateral-facing apertures of the ablation cap in a plurality of second directions, respectively, the plurality of second directions orientated laterally away from the catheter tip and different from the first direction.17. The catheter of claim 16 , wherein the ablation electrode comprises an RF ablation electrode.18. The catheter of claim 16 , wherein the first and second ultrasound transducer elements are mounted on a base ...

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Номер записи: 49
18-01-2018 дата публикации

APPARATUS FOR MANUALLY MANIPULATING HOLLOW ORGANS

Номер: US20180015268A1
Автор: Fojtik Shawn P.
Принадлежит:

An apparatus for mechanically manipulating hollow organs within the body of a subject, or an organ manipulation apparatus, includes a manipulation section. The manipulation section may include a substantially two-dimensional element, which may have a width that exceeds a distance across a portion of the interior of a hollow organ within which the manipulation section is to be positioned. The manipulation section is configured to manipulate at least a portion of a hollow organ from within, which may modify at least one of a shape, orientation, or location of at least part of the hollow organ. Methods for manipulating hollow organs are also disclosed, as are operating techniques, such as left atrial ablation, in which the shapes, orientations, and/or locations of hollow organs are manipulated to move the hollow organs away from the site of the medical procedure, reducing the potential for damage to the hollow organs. 1. An apparatus for manipulating an esophagus , comprising: a distal end;', 'a proximal end opposite from the distal end;', 'a proximal portion adjacent to the proximal end, the proximal portion being substantially linear or substantially curvilinear; and', 'a distal portion adjacent to the distal end, a manipulation section of the distal portion having a substantially two-dimensional configuration defined by a series of bends, the substantially two-dimensional configuration having a width of more than 14 mm., 'an elongate element consisting of2. The apparatus of claim 1 , wherein the elongate element has a substantially solid structure.3. The apparatus of claim 1 , wherein the elongate element is radiopaque.4. The apparatus of claim 1 , wherein the elongate element is a wire.5. The apparatus of claim 1 , wherein the elongate element has a diameter of about 0.035 inch to about 0.038 inch.6. The apparatus of claim 1 , wherein the manipulation section is made of a shape memory alloy.7. The apparatus of claim 1 , wherein the series of bends in the distal ...

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Номер записи: 50
21-01-2021 дата публикации

Intravascular catheter with peri-vascular nerve activity sensors

Номер: US20210015381A1
Автор: David R. Fischell, Steven ALMANY, Tim A. Fischell, Vartan Ghazarossian
Принадлежит: Ablative Solutions Inc

An intravascular catheter for peri-vascular nerve activity sensing or measurement includes multiple needles advanced through supported guide tubes (needle guiding elements) which expand with open ends around a central axis to contact the interior surface of the wall of the renal artery or other vessel of a human body allowing the needles to be advanced though the vessel wall into the perivascular space. The system also may include means to limit and/or adjust the depth of penetration of the needles. The catheter also includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened needles are advanced to penetrate into the vessel wall. The addition of an injection lumen at the proximal end of the catheter and openings in the needles adds the functionality of ablative fluid injection into the perivascular space for an integrated nerve sending and ablation capability.

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Номер записи: 51
24-01-2019 дата публикации

CATHETER SYSTEM AND METHODS OF MEDICAL USES OF SAME, INCLUDING DIAGNOSTIC AND TREATMENT USES FOR THE HEART

Номер: US20190021673A1
Автор: Beatty Graydon E., CORVI Timothy J., FLAHERTY J. Christopher, Julian Marcus Frederick, WERNETH Randell L.
Принадлежит:

The present invention includes systems, devices and methods for treating and/or diagnosing a heart arrhythmia, such as atrial fibrillation. Specifically, the present invention provides a system including a diagnostic catheter and an ablation catheter. The diagnostic catheter includes a shaft, multiple dipole mapping electrodes and multiple ultrasound transducers. The ablation catheter is slidingly received by the diagnostic catheter shaft. 1. (canceled)2. A catheter system , comprising: an elongate shaft comprising a distal end;', 'an expandable assembly mounted to the elongate shaft, the expandable assembly comprising multiple splines and configured to transition from a compacted state to an expanded state;', 'a plurality of electrodes coupled to the multiple splines of the expandable assembly, each electrode configured to emit electric signals and record electric signals; and', 'a plurality of ultrasound transducers coupled to the multiple splines of the expandable assembly;, 'a diagnostic catheter comprisinga distance measurement assembly configured to drive the plurality of ultrasound transducers to produce anatomical geometry data, and including data representing a distance between each ultrasound transducer of the plurality of ultrasound transducers and a tissue surface orthogonal to each ultrasound transducer; and measure spacing between two or more of the electrodes based on the recorded electric signals and to determine a geometric configuration of one or more of the multiple splines based on the measured electrode spacing; and', 'create a three-dimensional anatomical map based on the produced anatomical geometry data, create electrical information based on the recorded electric signals, and display the electrical information in relation to the three-dimensional anatomical map,', the electrical information is further based on the determined geometric configuration of the one or more of the multiple splines, and/or', 'the anatomical geometry data is based on ...

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Номер записи: 52
24-01-2019 дата публикации

SYSTEM AND METHOD FOR CONTROLLING DELIVERY OF ABLATION ENERGY TO TISSUE

Номер: US20190021790A1
Автор: Olson Eric Steven
Принадлежит:

A system for controlling delivery of ablation energy by an ablation catheter to tissue in a body is provided. The system includes an electronic control unit configured to determine, responsive to a measurement signal from the ablation catheter, a value for a characteristic associated with the delivery of ablation energy to the tissue. In one embodiment, the characteristic is the degree of contact between the ablation catheter and the tissue. The unit is further configured to generate a control signal, responsive to the determined value of the characteristic, to control an amount of energy delivered from an ablation delivery element on the ablation catheter to the tissue. The amount of energy varies in response to the determined value of the characteristic when the determined value of the characteristic meets a predetermined condition relative to a threshold value for the characteristic. 120.-. (canceled)21. A method for controlling delivery of energy to an electrode , comprising:delivering an amount of energy to the electrode;receiving, with a processor, a measurement signal indicative of an amount of particulates in a bloodstream of a patient in which the electrode has been inserted; andvarying the amount of energy based on the measurement signal.22. The method of claim 21 , wherein the measurement signal includes a signal indicative of blood flow velocity in a blood vessel of the patient.23. The method of claim 22 , wherein the measurement signal indicative of blood flow velocity in the blood vessel of the patient is generated from an image of a brain of the patient.22. The method of claim 21 , wherein the method includes implementing a closed-loop feedback method for varying the amount of energy.23. The method of claim 21 , further comprising generating a control signal from the measurement signal.24. The method of claim 23 , further comprising providing the control signal to a generator claim 23 , the control signal being configured to cause the generator to ...

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Номер записи: 53
01-02-2018 дата публикации

Stereo-thermo-lesioning to treat a patient's neurological condition

Номер: US20180028807A1
Автор: Andre G. Machado, Imad Najm, John T. Gale, Jorge A. GONZALEZ-MARTINEZ
Принадлежит: CLEVELAND CLINIC FOUNDATION

This disclosure relates to using stereo-thermo-lesioning (STL) to create lesions at one or more locations in the patient's nervous system at the patient's bedside without general anesthesia. A method that uses STL to treat a patient's neurological condition includes: using a plurality of stereotactically-implanted thermo-coupled multi-contact electrodes to record conduction data within a predetermined theoretical zone of activity within the patient's neurological tissue; detecting abnormal neurological activity of a neurological condition within the conduction data and localize a portion of the predetermined theoretical zone of activity that is responsible for a primary organization of the abnormal neurological activity; creating a lesion at the portion of the predetermined theoretical zone of activity that is responsible for a primary organization of the abnormal neurological activity using at least one contact of the plurality of thermo-coupled multi-contact electrodes.

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Номер записи: 54
24-04-2014 дата публикации

Catheter system

Номер: US20140114307A1
Автор: Marius J. Postma, Saar Moisa
Принадлежит: Kardium Inc

A manipulable portion of a catheter system advances out of a lumen of a catheter sheath at a distal end of a shaft, which is also within the lumen of the catheter sheath. The catheter system causes different advancement and retraction trajectories of a manipulable portion out of and into the lumen based at least upon different relative movements between the catheter sheath and the shaft. A projection and a corresponding receiver may be used to control relative positioning of the catheter sheath and the shaft, as well as to control positioning of the manipulable portion. The catheter system may control metering rates of a control element coupled to the manipulable portion during advancement and retraction of the manipulable portion. A control element of the catheter system has varying amounts of length outside a distal end of the catheter sheath during advancement and retraction of the manipulable portion.

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Номер записи: 55
17-02-2022 дата публикации

Systems and methods for treating tissue with pulsed field ablation

Номер: US20220047319A1
Автор: Gerald Floyd Cummings, Shane Fredrick Miller-Tait
Принадлежит: Kardium Inc

Pulsed field ablation systems are disclosed, some of which may include an output pulse generation circuit and a high voltage pulse generation circuit electrically connected to the output pulse generation circuit. The high voltage pulse generation circuit may be configured to deliver a high voltage pulse set to the output pulse generation circuit. The output pulse generation circuit may be configured to generate an output pulse set at least in response to the high voltage pulse set. The output pulse set may be deliverable to a set of selectable electrodes and may be configured to cause pulsed field ablation of tissue. Each pulse in the output pulse set may have a rise time that is shorter than a rise time of at least one high voltage pulse in the high voltage pulse set.

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Номер записи: 56
17-02-2022 дата публикации

Applying Bipolar Ablation Energy Between Shorted Electrode Groups

Номер: US20220047326A1
Автор: Andres Claudio Altmann, Assaf Govari
Принадлежит: Biosense Webster Israel Ltd

A system includes a catheter, a switching assembly, and a processor. The catheter including an expandable frame, which is coupled to a distal end of the catheter, and multiple electrodes, which are disposed on the expandable frame in a radial geometry. The switching assembly is electrically connected to the catheter, and is configured to electrically short between selected ones of the electrodes. The processor is configured, for first and second disjoint groups of the electrodes, to control the switching assembly to electrically short the electrodes within each of the first and second groups, for applying one or more bipolar ablation energy between the first and second groups when the electrodes are placed in contact with a target tissue of the organ.

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Номер записи: 57
31-01-2019 дата публикации

SYSTEMS AND METHODS FOR SELECTING, ACTIVATING, OR SELECTING AND ACTIVATING TRANSDUCERS

Номер: US20190029608A1
Автор: Moisa Saar, WEBER Michael Hermann
Принадлежит:

A graphical representation may be displayed including at least a plurality of transducer graphical elements, each transducer graphical element of the plurality of transducer graphical elements representative of a respective transducer of a plurality of transducers of a transducer-based device. A set of user input may be received including an instruction set to reposition a first transducer graphical element in a state in which the first transducer graphical element is located at a first location in the graphical representation and a second transducer graphical element is located at a second location in the graphical representation, the second location closer to a predetermined location in the graphical representation than the first location. In response to conclusion of receipt of the set of user input, the first transducer graphical element may be repositioned from the first location in the graphical representation to the predetermined location in the graphical representation. 1. A medical device system comprising:a data processing device system;an input-output device system communicatively connected to the data processing device system; anda memory device system communicatively connected to the data processing device system and storing a program executable by the data processing device system, the program comprising:communication instructions configured to cause the data processing device system to communicate, via the input-output device system, with an electrode-based device system comprising a structure and a plurality of electrodes arrangeable in a three dimensional distribution on the structure, the structure and the plurality of electrodes locatable within a bodily cavity;first display instructions configured to cause the input-output device system to display information regarding at least the electrode-based device system, the displayed information including a graphical representation of at least a portion of the electrode-based device system, the graphical ...

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Номер записи: 58
31-01-2019 дата публикации

SYSTEMS AND METHODS FOR SELECTING, ACTIVATING, OR SELECTING AND ACTIVATING TRANSDUCERS

Номер: US20190029609A1
Автор: Moisa Saar, WEBER Michael Hermann
Принадлежит:

A graphical representation may be displayed including at least a plurality of transducer graphical elements, each transducer graphical element of the plurality of transducer graphical elements representative of a respective transducer of a plurality of transducers of a transducer-based device. A set of user input may be received including an instruction set to reposition a first transducer graphical element in a state in which the first transducer graphical element is located at a first location in the graphical representation and a second transducer graphical element is located at a second location in the graphical representation, the second location closer to a predetermined location in the graphical representation than the first location. In response to conclusion of receipt of the set of user input, the first transducer graphical element may be repositioned from the first location in the graphical representation to the predetermined location in the graphical representation. 1. A medical device system comprising:a data processing device system;an input-output device system communicatively connected to the data processing device system; anda memory device system communicatively connected to the data processing device system and storing a program executable by the data processing device system, the program comprising:communication instructions configured to cause the data processing device system to communicate, via the input-output device system, with an electrode-based device system comprising a structure and a plurality of electrodes arrangeable in a three dimensional distribution on the structure, the structure and the plurality of electrodes locatable within a bodily cavity, and the structure including a first domed portion and a part other than the first domed portion;first display instructions configured to cause the input-output device system to display information regarding at least the electrode-based device system, the displayed information including a ...

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Номер записи: 59
31-01-2019 дата публикации

ELECTRODE ASSEMBLY WITH THERMAL SHUNT MEMBER

Номер: US20190029752A1
Автор: Koblish Josef Vincent, Panescu Dorin, Schultheis Eric Andrew
Принадлежит:

According to some embodiments, a medical instrument (for example, an ablation device) comprises an elongate body having a proximal end and a distal end, an energy delivery member positioned at the distal end of the elongate body, a first plurality of temperature-measurement devices carried by or positioned within the energy delivery member, the first plurality of temperature-measurement devices being thermally insulated from the energy delivery member, and a second plurality of temperature-measurement devices positioned proximal to a proximal end of the energy delivery member, the second plurality of temperature-measurement devices being thermally insulated from the energy delivery member. 1. (canceled)2. An electrode assembly for an ablation catheter with thermal shunting , the electrode assembly comprising:a proximal electrode portion;a distal electrode portion;a filtering element electrically coupling the proximal electrode portion to the distal electrode portion and configured to present a low impedance at a frequency used for delivering ablative energy via the proximal and distal electrode portions; andat least one thermal shunt member in thermal communication with the proximal electrode portion and the distal electrode portion to selectively remove heat from at least one of the electrode assembly and tissue being treated by the electrode assembly when the electrode assembly is activated;wherein the at least one thermal shunt member extends at least partially through an interior of the electrode assembly to transfer heat from the electrode assembly during use;wherein the at least one thermal shunt member is configured to receive at least one fluid conduit extending at least partially through an interior of the at least one thermal shunt member, wherein the at least one thermal shunt member is in thermal communication with the at least one fluid conduit; andwherein the at least one fluid conduit is configured to place the electrode assembly in fluid ...

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Номер записи: 60
31-01-2019 дата публикации

METHODS OF REMOVING HEAT FROM AN ELECTRODE USING THERMAL SHUNTING

Номер: US20190029753A1
Автор: Koblish Josef Vincent, Panescu Dorin, Schultheis Eric Andrew
Принадлежит:

According to some embodiments, a medical instrument (for example, an ablation device) comprises an elongate body having a proximal end and a distal end, an energy delivery member positioned at the distal end of the elongate body, a first plurality of temperature-measurement devices carried by or positioned within the energy delivery member, the first plurality of temperature-measurement devices being thermally insulated from the energy delivery member, and a second plurality of temperature-measurement devices positioned proximal to a proximal end of the energy delivery member, the second plurality of temperature-measurement devices being thermally insulated from the energy delivery member. 1. (canceled)2. A method of heat removal from an electrode assembly during a tissue treatment procedure , the method comprising:delivering energy to an electrode assembly of an ablation system, the ablation system comprising a catheter comprising a distal end, the electrode assembly positioned along the distal end of the catheter;wherein the catheter of the ablation system comprises at least one thermal shunt member along its distal end,wherein the at least one thermal shunt member extends at least partially through an interior of the electrode assembly; andwherein the catheter further comprises at least one fluid passage extending at least partially through the interior of the electrode assembly and an interior of the at least one thermal shunt member;delivering a fluid through the at least one fluid passage; andtransferring heat from the electrode assembly to the fluid via the at least one thermal shunt member to reduce the likelihood of localized hot spots along the distal end of the catheter.3. The method of claim 2 ,{'sup': '2', 'wherein the at least one thermal shunt member is configured to transfer heat while not retaining heat, and wherein the at least one thermal shunt member comprises a thermal diffusivity greater than 1.5 cm/sec;'}wherein the electrode assembly ...

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Номер записи: 61
31-01-2019 дата публикации

Expandable elements for delivery of electric fields

Номер: US20190030328A1
Автор: Brian T. HOWARD, Mark T. Stewart
Принадлежит: MEDTRONIC INC

A method, system, and device for electroporation. A system may include a medical device with a plurality of electrodes borne on an expandable element and an energy generator in communication with the electrodes. The energy generator may have processing circuitry configured to selectively deliver electroporation energy to at least one of the electrodes. The processing circuitry may determine whether an alert condition is present and, if so, cease the delivery of electroporation energy to one or more electrodes identified as the cause of the alert condition and/or prevent the delivery of electroporation energy to the one or more electrodes identified as the cause of the alert condition. The energy generator may also be configured to deliver electroporation energy in a sequence of a plurality of energy delivery patterns to enhance lesion formation.

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Номер записи: 62
30-01-2020 дата публикации

Systems and methods for activating transducers

Номер: US20200030019A1
Автор: Daniel M. Reinders, Daniel R. Weinkam
Принадлежит: Kardium Inc

In some embodiments, a plurality of transducers of a transducer-based device may be selected for activation. A first pair of subsets of the selected transducers may be identified for initial activation, each subset of the first pair being activated with a different phase angle range than the other. No transducer in one subset is sufficiently close to a transducer in the other subset to cause a confluence of ablated tissue regions therebetween. The first pair of subsets may be activated simultaneously or concurrently. Upon activation or a conclusion thereof of the pair of subsets of the selected transducers, one or more subsequent pairs of subsets of the selected transducers may be activated iteratively on a pair-by-pair basis, until all of the selected transducers have achieved desired activation results, according to some embodiments. Each subsequent pair may include the same or similar characteristics as the first pair.

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Номер записи: 63
04-02-2021 дата публикации

Catheters, catheter systems, and methods for puncturing through a tissue structure and ablating a tissue region

Номер: US20210031020A1
Автор: Steven Richard Mickelsen
Принадлежит: University of Iowa Research Foundation UIRF

A percutaneous catheter system for use within the human body and an ablation catheter for ablating a selected tissue region within the body of a subject. The percutaneous catheter system can include two catheters that are operatively coupled to one another by magnetic coupling through a tissue structure. The ablation catheter can include electrodes positioned within a central portion. The ablation catheter is positioned such that the central portion of a flexible shaft at least partially surrounds the selected tissue region. Each electrode of the ablation catheter can be activated independently to apply ablative energy to the selected tissue region. The ablation catheter can employ high impedance structures to change the current density at specific points. Methods of puncturing through a tissue structure using the percutaneous catheter system are disclosed. Also disclosed are methods for ablating a selected tissue region using the ablation catheter.

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Номер записи: 64
09-02-2017 дата публикации

DEPLOYMENT CONTROL APPARATUS FOR A CATHETER WITH A DEPLOYABLE ARRAY

Номер: US20170035311A1
Автор: Collier Ian, Guggenberger Kurt E., Harlev Doron, Quinn William
Принадлежит:

A deployment control apparatus to control deployment of an array at an end of a catheter includes a pair of walls, a slider assembly, and a deployment shaft. The walls project from a first surface of the interior of a handle. The slider assembly includes a rigid body, an elastomeric element, a tab, and a knob. The elastomeric element is connected to the rigid body and at least partially disposed between the walls to frictionally engage with a surface of each wall. The knob is connected to the rigid body and is configured to maintain the elastomeric element between the walls. The deployment shaft connects the rigid body to the array, wherein a force applied to the knob sufficient to overcome the frictional engagement between the elastomeric element and the surface of each wall causes movement of the slider assembly and the deployment shaft to control deployment of the array. 1. A deployment control apparatus substantially contained within a handle at one end of a catheter to control deployment of an array at another end of the catheter , the deployment control apparatus comprising:a pair of walls projecting from a first surface of the interior of the handle, the walls disposed on opposite sides of a slot extending along a portion of the handle between the interior of the handle and an exterior of the handle; a rigid body;', 'an elastomeric element connected to the rigid body and at least partially disposed between the walls, wherein the elastomeric element frictionally engages with a surface of each wall;', 'a tab connected to the rigid body and projecting from the rigid body and through the slot to the exterior of the handle; and', 'a knob connected to the tab at the exterior of the handle, wherein the knob is configured to maintain the elastomeric element between the walls; and', 'a deployment shaft connecting the rigid body to the array, wherein a force applied to the knob sufficient to overcome the frictional engagement between the elastomeric element and the ...

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Номер записи: 65
11-02-2016 дата публикации

Wavefront analysis based on ablation parameters

Номер: US20160038047A1
Автор: Assaf Pressman, Eliahu Zino, Roy Urman, Shmuel Auerbach, Yaniv Ben Zriham
Принадлежит: Biosense Webster Israel Ltd

A method, including recording parameters indicative of a quality of ablation performed at one or more sites in a region of a human heart, and receiving a set of electrophysiological signals indicative of a wave of electrical activation flowing through the region. The method further includes identifying locations within the region at which the wave is blocked from flowing and estimating confidence levels with respect to a blockage of the wave at the locations in response to the signals and the parameters. The method also includes displaying a map of the human heart including an indication of the confidence levels.

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Номер записи: 66
08-02-2018 дата публикации

Method and System for Connecting a Lead to Cardiac Tissue

Номер: US20180036035A1
Автор: Benno Lansdorp, Hernes Jacobs, Maria Cornelia Ruijter, Massimo Mariani, Theodorus Johannes Klinkenberg
Принадлежит: Academisch Ziekenhuis Gronigen, Demcon Advanced Mechatronics BV

The invention relates to a method of connecting a lead to cardiac tissue in a patient's body, comprising the steps of: a) providing an elongated hollow delivery tool having a proximal end and a distal end, b) inserting the distal end of the tool into the patient's body, c) navigating the delivery tool until its distal end contacts the cardiac tissue at a contact location, d) determining if the contact location is suitable for connection of the lead, e) if the contact location is deemed suitable, fixedly connecting an electrode of the lead to the cardiac tissue at that location, and f) if the contact location is not deemed suitable, moving the distal end of the delivery tool away from the cardiac tissue and navigating the delivery tool until its distal end contacts the cardiac tissue at an alternative contact location that is spaced apart from the previous contact location, and repeating step d). The invention further relates to a system for connecting a lead to cardiac tissue in a patient's body, comprising: an elongated hollow delivery tool having a proximal end and a distal end, the distal end being arranged for insertion into the patient's body, a navigating device for navigating the distal end of the delivery tool to a contact location on the cardiac tissue, a determinator for determining the suitability of the contact location, and a connecting device for fixedly connecting an electrode of the lead to the cardiac tissue at a selected contact location.

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Номер записи: 67
08-02-2018 дата публикации

CATHETER WITH SOFT DISTAL TIP FOR MAPPING AND ABLATING TUBULAR REGION

Номер: US20180036078A1
Автор: Ditter Tom Allen
Принадлежит:

A catheter includes an elongated body having a longitudinal axis, a distal assembly distal the elongated body, the distal assembly having a tapered helical form comprising a larger, electrode-carrying proximal loop and a smaller, softer distal loop, and a shape-memory support member extending through at least the proximal loop. For example, the helical loop subtends at least about 720 radial degrees, with the proximal loop subtending about 360 radial degrees, and the distal loop subtending about 360 radial degrees. The softer distal loop with a straight distal end atraumatically guides the distal assembly into a tubular region so that the larger proximal loop can sit on the ostium of the tubular region with improved electrode and tissue contact. 1. A catheter comprising:an elongated catheter body having a longitudinal axis;a distal assembly distal the elongated body, the distal assembly having a helical form comprising a proximal loop and a distal loop, and a shape-memory support member extending through at least the proximal loop, the proximal loop having a lesser flexibility than the distal loop, and the distal loop having a greater flexibility than the proximal loop;at least one proximal loop ring electrode mounted on the proximal loop;a control handle proximal the elongated body; anda contraction wire having a proximal end in the control handle and a distal end anchored in the proximal loop, the control handle including a first control member configured to actuate the contraction wire to contract the proximal loop.2. A catheter of claim 1 , wherein the helical loop subtends at least about 720 radial degrees.3. A catheter of claim 1 , wherein the helical loop subtends about 765 radial degrees.4. The catheter of claim 1 , wherein the proximal loop subtends at least 360 radial degrees.5. The catheter of claim 1 , wherein the proximal loop subtends about 405 radial degrees.6. The catheter of claim 1 , wherein the distal loop subtends about 360 radial degrees.7. The ...

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Номер записи: 68
08-02-2018 дата публикации

CATHETER WITH DISTAL SECTION HAVING SIDE-BY-SIDE LOOPS

Номер: US20180036079A1
Автор: BASU Shubhayu, Hoitink Ryan
Принадлежит:

The catheter allows mapping and/or ablation of the area around two or more PV ostia at the same time, with a single placement of a distal section of the catheter having a 2D configuration resembling an infinity or lazy 8 symbol. The catheter has an elongated catheter body, a distal section having at least a flexible elongated member with shape memory, the member being configured to assume a 2D configuration resembling an infinity symbol, and at least one electrode mounted on the member. The 2D configuration resembles a first loop and a second loop, wherein the first and second loops are side-by-side, generally extending in a common plane. 1. A method of simultaneously mapping or ablating at least two tubular regions , the method comprising: an elongated catheter body;', 'a distal section having at least a first flexible elongated member with shape memory, the first member being configured to assume a 2D configuration resembling an infinity symbol and having first and second portions;', 'at least one first electrode mounted on the first portion of the 2D configuration; and', 'at least one second electrode mounted on the second portion of the 2D configuration;, 'introducing a catheter comprisingcontacting tissue around a first tubular region with a first portion of the 2D configuration, and contacting tissue around a second tubular region with a second portion of the 2D configuration; andsimultaneously ablating or mapping the tissue around the first and second tubular regions with the at least one first electrode and the at least one second electrode.2. The method of claim 1 , wherein the first portion of the 2D configuration resembles a first loop and the second portion of the 2D configuration resembles a second loop claim 1 , wherein the first and second loops are side-by-side claim 1 , generally extending in a common plane.3. The method of claim 1 , wherein the first member has a distal S configuration and a proximal S configuration claim 1 , wherein the S ...

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Номер записи: 69
24-02-2022 дата публикации

Devices and methods for an expandable assembly catheter

Номер: US20220054192A1
Автор: Athanassios Papaioannou, Christopher Thomas Beeckler, Joseph Thomas Keyes, Kevin Justin HERRERA
Принадлежит: Biosense Webster Israel Ltd

A catheter apparatus includes an elongated deflectable element including a distal end, a coupler connected to the distal end, a pusher including a distal portion, and configured to be advanced and retracted through the deflectable element, and an expandable assembly including flexible polymer circuit strips, each strip including electrodes disposed thereon. The strips can be configured to bow radially outward when the pusher is retracted expanding the expandable assembly from a collapsed form to an expanded form. A covering can at least partially enclose the flexible polymer circuit strip and the multiple electrodes. The covering can include a plurality of apertures at each electrode so that a portion of the conductive surface of each electrode is exposed through each aperture.

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Номер записи: 70
07-02-2019 дата публикации

METHOD FOR ANALYSIS OF COMPLEX RHYTHM DISORDERS

Номер: US20190038157A1
Автор: Narayan Sanjiv M., Rappel Wouter-Jan
Принадлежит: The Regents of the University of California

A method of analyzing a complex rhythm disorder in a human heart includes accessing signals from a plurality of sensors disposed spatially in relation to the heart, where the signals are associated with activations of the heart, and identifying a region of the heart having an activation trail that is rotational or radially emanating, where the activation trail is indicative of the complex rhythm disorder and is based on activation times associated with the activations of the heart. 1. A method for analyzing a source of a complex heart rhythm disorder in a patient , the method comprising:collecting signals generated by a catheter assembly having a plurality of sensors positioned to detect cardiac activations at a plurality of locations associated with the patient's heart over a time period corresponding to a plurality of heart beats; identifying within each collected signal an activation onset of a heart beat detected by a sensor corresponding to a location of the plurality of locations;', 'organizing a sequence of activation onsets for the plurality of sensors based on one or more of occurrence over the time period and positions of the sensors to generate an activation trail;', 'determining a sensor map corresponding to the plurality of sensor locations; and', 'associating the activation trail with the sensor map to determine whether a discernible signature pattern is generated;', "if a discernible signature pattern is generated, determining at least one approximate core region, wherein the discernible signature pattern and the at least one approximate core region are indicative of a type of heart rhythm disorder and its location within the patient's heart; and"], 'inputting data comprising the collected signals and the plurality of locations into a computer processor configured for analyzing the signals bydisplaying a clinical representation of the discernible signature pattern and the at least one approximate core region on a graphical display device, wherein the ...

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Номер записи: 71
07-02-2019 дата публикации

APPARATUS FOR ACQUIRING ELECTRIC ACTIVITY IN THE BRAIN AND UTILIZATION OF THE SAME

Номер: US20190038168A1
Автор: CHIKEN Satomi, NAMBU Atsushi, NISHIMURA Yukio, TAKARA Sayuki
Принадлежит: INTER-UNIVERSITY RESEARCH INSTITUTE CORPORATION NATIONAL INSTITUTES OF NATURAL SCIENCES

The present disclosure provides an apparatus including: one or more needle-like bases enabled to be inserted into the brain; a first electrode having a first impedance and enabling an input of an electric activity of a nucleus with which the first electrode comes into contact; and a second electrode having a second impedance lower than the first impedance and being able to output an electric stimulation to the nucleus, wherein the first electrode is provided at a tip portion of at least one of the bases, and the second electrode is provided on a part of the at least one of the bases at a position identical to a position of at least one of the first electrode or on a proximal side with respect to the first electrode, in a direction along a long axis of the base on which the first electrode is provided. 123-. (canceled)24. A method of using an electric activity information in brain , the method using an apparatus:one or more needle-like base enabled to be inserted to the brain,a first electrode a first impedance and acquiring an input of an electric activity of a brain tissue with which the first electrode comes into contact and being provided at a portion of the at least one of the one or more bases;a pair of second electrodes having a second impedance lower than the first impedance, applying an electric stimulation to the brain tissue and being provided at portions of the at least one of the one or more bases,wherein the first electrode is positioned at a tip portion of the at least one of the one or more bases and the second electrodes are aligned along the long axis of at least one of the one or more bases at positions closer to a proximal end than the first electrode, outputting one or more electric stimulations of one or more single stimulations and/or one or more repetitive stimulations,', 'receiving one or more electric activities in the brain tissue induced based on the one or more electric stimulations output from the second electrodes; and', 'deciding the ...

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Номер записи: 72
07-02-2019 дата публикации

Ablation check pulse routine and integration for electroporation

Номер: US20190038171A1
Автор: Brian T. HOWARD
Принадлежит: MEDTRONIC INC

Devices, systems, and methods relating to a low-voltage, pre-treatment pulse routine for evaluating a potential for non-target tissue damage from the delivery of energy, such as electroporation energy to an area of target tissue. In one embodiment, a medical system includes a medical device having a treatment element; and a control unit in communication with the medical device, the control unit being configured to: deliver a low-voltage, pre-treatment pulse routine through the treatment element to an area of target tissue; determine whether the low-voltage, pre-treatment pulse routine has a stimulation effect on an area of non-target tissue; and deliver an ablation energy routine through the treatment element to the area of target tissue when the control unit determines that the low-voltage, pre-treatment pulse routine does not have a stimulation effect on the area of non-target tissue.

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Номер записи: 73
07-02-2019 дата публикации

Instrument For Therapeutically Cytotoxically Ablating Parathyroidal Tissue Within A Parathyroid Gland

Номер: US20190038334A1
Автор: Schwartz Alan N.
Принадлежит:

An instrument for therapeutically cytotoxically ablating parathyroidal tissue is disclosed. A substance is capable of transforming the parathyroid gland from overproduction of parathyroid hormone when the substance's quantity exceeds a set amount, and is capable of transforming the parathyroid gland from overproduction only when activated by application of sufficient units of an electromagnetic energy having a frequency ranging from 400 THz to 30 PHz when the substance's quantity is below the set amount. A delivery device is operable to introduce the substance into the parathyroidal tissue and to quantitatively limit the quantity to below the set amount. An energy device is operable to apply units of the electromagnetic energy after the substance has been introduced. A sensor is operable to monitor the activation of the substance as the electromagnetic energy is applied. The energy device is further operable to modulate applying the electromagnetic energy when the substance has been activated. 1. An instrument for therapeutically cytotoxically ablating parathyroidal tissue within a parathyroid gland , comprising:a substance capable of cytotoxic ablation of a parathyroid gland of a living human, wherein the substance alone is capable of transforming the parathyroid gland from overproduction to non-overproduction of parathyroid hormone when a quantity of the substance exceeds a set amount, and the substance is capable of transforming the parathyroid gland from overproduction to non-overproduction of the parathyroid hormone only when activated in the parathyroidal tissue by application of sufficient units of an electromagnetic energy having a frequency ranging from 400 THz to 30 PHz when the quantity of the substance is below the set amount;a substance delivery device operable to introduce the substance into the parathyroidal tissue and to quantitatively limit the quantity of the substance being introduced to below the set amount;an electromagnetic energy treatment ...

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Номер записи: 74
07-02-2019 дата публикации

ABLATION SYSTEMS WITH MULTIPLE TEMPERATURE SENSORS

Номер: US20190038347A1
Автор: Johnson Jessi E., Koblish Josef Vincent, Panescu Dorin, Schultheis Eric Andrew
Принадлежит:

According to some embodiments, a medical instrument (for example, an ablation device) comprises an elongate body having a proximal end and a distal end, an energy delivery member positioned at the distal end of the elongate body, a first plurality of temperature-measurement devices carried by or positioned within the energy delivery member, the first plurality of temperature-measurement devices being thermally insulated from the energy delivery member, and a second plurality of temperature-measurement devices positioned proximal to a proximal end of the energy delivery member, the second plurality of temperature-measurement devices being thermally insulated from the energy delivery member. 1. (canceled)2. A cardiac ablation system , comprising:a catheter comprising an electrode assembly, the electrode assembly comprising a proximal electrode and a distal electrode, wherein the proximal electrode is separated from the distal electrode by a gap; andan energy delivery device configured to deliver energy at a frequency within an ablation radiofrequency range to the electrode assembly;wherein the proximal electrode is operatively coupled to the distal electrode using a filtering element at the ablation radiofrequency range such that the proximal electrode and the distal electrode function like a single electrode, and wherein the proximal electrode and the distal electrode function as separate electrodes at high-resolution mapping frequencies;wherein the system is configured to receive signals indicative of temperature from at least one temperature sensor positioned along the proximal electrode or distal electrode;wherein the system is configured to determine, upon execution of instructions stored on a non-transitory storage medium by a hardware processor, temperature measurements from the signals received from the at least one temperature sensor; andwherein the system is configured to adjust one or more treatment parameters of the ablation procedure based, at least in ...

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Номер записи: 75
07-02-2019 дата публикации

TISSUE ABLATION AND MONITORING THEREOF

Номер: US20190038350A1
Автор: Claude John P., SALAHIEH Amr, SAUL Tom
Принадлежит:

An ablation catheter including an elongate shaft, an inflatable balloon positioned at a distal region of the elongate shaft, a first ablation electrode disposed outside of and carried by an outer surface of the inflatable balloon, a first ultrasound transducer disposed outside of the inflatable balloon, and a flexible circuit. The flexible circuit includes a first conductor and a second conductor and is disposed outside of and carried by the outer surface of the inflatable balloon. The first conductor is in electrical communication with the first ablation electrode, and the second conductor in electrical communication with the first ultrasound transducer. 1. An ablation catheter , comprising:an elongate shaft;an inflatable balloon positioned at a distal region of the elongate shaft;a first ablation electrode disposed outside of and carried by an outer surface of the inflatable balloon;a first ultrasound transducer disposed outside of the inflatable balloon; anda flexible circuit, including a first conductor and a second conductor, disposed outside of and carried by the outer surface of the inflatable balloon, the first conductor in electrical communication with the first ablation electrode, and the second conductor in electrical communication with the first ultrasound transducer.2. The ablation catheter of claim 1 , wherein the first ultrasound transducer is positioned within a periphery of the first ablation electrode.3. The ablation catheter of claim 1 , wherein the first ultrasound transducer is disposed under the first ablation electrode.4. The ablation catheter of claim 1 , wherein the first ultrasound transducer is an ultrasound receiver.5. The ablation catheter of claim 1 , wherein the first ultrasound transducer is an ultrasound emitter.6. The ablation catheter of claim 1 , wherein the first ultrasound transducer is at least partially surrounded by an insulation layer.6. The ablation catheter of claim 1 , further comprising:a second ultrasound transducer ...

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Номер записи: 76
07-02-2019 дата публикации

Methods of cardiac mapping and model merging

Номер: US20190038357A1
Автор: Steve Adler
Принадлежит: Catheter Precision Inc

Various embodiments provide a cardiac mapping and model merging method including: generating a premature ventricular contraction (PVC) activation map of a heart based on a three-dimensional (3D) heart model and PVC electrocardiogram (ECG) data recording during PVC of the heart; generating a 3D internal surface model of the heart by triangulating point-by-point contact data collected during an electrophysiology (EP) procedure; merging the 3D activation map and the 3D internal surface model to form a PVC activation surface model; and pacing the heart at a first pacing location disposed in an area of earliest activation identified in PVC activation surface model.

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Номер записи: 77
07-02-2019 дата публикации

Methods of cardiac mapping and directional guidance

Номер: US20190038363A1
Автор: Steve Adler
Принадлежит: Catheter Precision Inc

Various embodiments provide a cardiac mapping method including: generating an activation map of a heart based on electrocardiogram (ECG) data of a heart and a three-dimensional (3D) heart model; performing an electrophysiology (EP) procedure to determine a first pacing location; pacing the heart at the first pacing location using an EP catheter; determining whether the pacing at the first pacing location generates a desired cardiac response; displaying guidance information related to a second pacing location on one or both of the activation map and the internal surface map, when the first pacing location is determined not to generate the desired cardiac response; moving the pacing catheter to the second pacing location, based on the guidance information; and pacing the heart at the second pacing location.

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Номер записи: 78
18-02-2021 дата публикации

SYSTEMS AND METHODS FOR ACTIVATING TRANSDUCERS

Номер: US20210045689A1
Автор: Bisalputra Danai, Louie Roxanne Wai Tak, Reinders Daniel Martin, Weinkam Daniel Robert
Принадлежит:

Transducer-based systems and methods may be configured to display a graphical representation of a transducer-based device, the graphical representation including graphical elements corresponding to transducers of the transducer-based device, and also including between graphical elements respectively associated with a set of the transducers and respectively associated with a region of space between the transducers of the transducer-based device. Selection of graphical elements and/or between graphical elements can cause activation of the set of transducers associated with the selected elements. Transducer activation characteristics, such as initiation time, activation duration, activation sequence, and energy delivery characteristics, can vary based on numerous factors. Visual characteristics of graphical elements and between graphical elements can change based on an activation-status of the corresponding transducers. Activation requests for a set of transducers can be denied if it is determined that a transducer in the set of transducers is unacceptable for activation. 1. (canceled)2. A transducer activation system comprising:a data processing device system;an input-output device system communicatively connected to the data processing device system; anda memory device system communicatively connected to the data processing device system and storing a program executable by the data processing device system,wherein the data processing device system is configured by the program at least to:cause reception, via the input-output device system, of user-based input indicating at least a selection of transducers from a plurality of transducers of a transducer-based device, the selected transducers activatable to form an ablation path in tissue; andcause activation, via the input-output device system and at least in part in response to the user-based input indicating at least the selection of the transducers, of multiple transducer sets from the selected transducers,wherein ...

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Номер записи: 79
18-02-2016 дата публикации

Utilization of electrode spatial arrangements for characterizing cardiac conduction conditions

Номер: US20160045133A1
Автор: Balachandran Ram K., Deno D. Curtis
Принадлежит:

A system and method are provided for determining electrophysiological data. The system comprises an electronic control unit that is configured to receive electrical signals from a set of electrodes, receive position and orientation data for the set of electrodes from a mapping system, compensate for position and orientation artifacts of the set of electrodes, compose cliques of a subset of neighboring electrodes in the set of electrodes, determine catheter orientation independent information of a target tissue, and output the orientation independent information to a display. The method comprising receiving electrogram data for a set of electrodes (), compensating for artifacts in sensor positions in the mapping system (), resolving the bipolar signals into a 3D vector electrogram in the mapping system coordinates (), manipulating observed unipolar voltage signals and the tangent component of the e-field to estimate the conduction velocity vector (), and outputting the catheter orientation independent information (). 1. A system for determining electrophysiological data , comprising: receive electrogram data for a set of electrodes;', 'receive position and orientation information for the set of electrodes from a mapping system;', 'determine catheter orientation independent information of a tissue; and', 'output the orientation independent information to a user or process., 'an electronic control unit configured to2. The system according to claim 1 , wherein the orientation independent information is at least one of a 2D vector electric field claim 1 , a 3D vector electric field claim 1 , a normal electric field claim 1 , a tangent electric field claim 1 , the eccentricity of the tangent electric field loop claim 1 , derived normal and tangent bipolar electrogram signals claim 1 , a wavefront conduction velocity claim 1 , or a unit direction vector.3. The system according to claim 1 , wherein the electronic control unit is further configured to compensate for ...

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Номер записи: 80
16-02-2017 дата публикации

Ablation systems and methods using heat shunt networks

Номер: US20170042613A1
Автор: Dorin Panescu, Eric Andrew SCHULTHEIS, Josef Vincent Koblish
Принадлежит: Advanced Cardiac Therapeutics Inc

According to some embodiments, a medical instrument (for example, an ablation device) comprises an elongate body having a proximal end and a distal end, an energy delivery member positioned at the distal end of the elongate body, a first plurality of temperature-measurement devices carried by or positioned within the energy delivery member, the first plurality of temperature-measurement devices being thermally insulated from the energy delivery member, and a second plurality of temperature-measurement devices positioned proximal to a proximal end of the energy delivery member, the second plurality of temperature-measurement devices being thermally insulated from the energy delivery member.

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Номер записи: 81
15-02-2018 дата публикации

METHODS AND APPARATUS FOR SELECTIVE TISSUE ABLATION

Номер: US20180042674A1
Автор: Mickelsen Steven Richard
Принадлежит:

Catheter systems and methods for the selective and rapid application of DC voltage to drive irreversible electroporation are disclosed herein. In some embodiments, an apparatus includes a voltage pulse generator and an electrode controller. The voltage pulse generator is configured to produce a pulsed voltage waveform. The electrode controller is configured to be operably coupled to the voltage pulse generator and a medical device including a series of electrodes. The electrode controller includes a selection module and a pulse delivery module. The selection module is configured to select a subset of electrodes from the series of electrodes. The selection module is configured identify at least one electrode as an anode and at least one electrode as a cathode. The pulse delivery module is configured to deliver an output signal associated with the pulsed voltage waveform to the subset of electrodes. 120-. (canceled)21. A method , comprising:identifying, via a selection module of an electrode controller, a plurality of anode/cathode pairs from a plurality of electrodes of a multi-electrode catheter, the multi-electrode catheter configured to be disposed about a portion of a heart, at least one anode/cathode pair including at least one anode electrode and at least one cathode electrode;conveying a pacing signal to a pacing lead configured to be operatively coupled to the heart;receiving, at a feedback module of the electrode controller, an electrocardiograph signal associated with a function of the heart; anddelivering, via a pulse delivery module of the electrode controller, a pulsed voltage waveform to the plurality of anode/cathode pairs according to a sequential pattern, the pulsed voltage waveform including a pre-polarizing pulse followed by a polarizing pulse, the pre-polarizing pulse being generated by utilizing voltage spikes generated from switching on a discharge of a capacitor bank.22. The method of claim 21 , wherein the identifying is based on an input ...

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Номер записи: 82
15-02-2018 дата публикации

METHODS AND APPARATUS FOR MULTI-CATHETER TISSUE ABLATION

Номер: US20180042675A1
Автор: Long Gary L.
Принадлежит:

Catheter systems, tools and methods are disclosed for the selective and rapid application of DC voltage to drive irreversible electroporation, with the system controller configurable to apply voltages to an independently selected subsets of electrodes, such that voltages of one polarity are applied to a multiplicity of electrodes on a first medical device and voltages of the opposite polarity to a multiplicity of electrodes on a second medical device. The first and second medical devices can be epicardial catheters positioned such that their opposing distal tips are approximately aligned and whose segments with electrodes collectively wrap around the pulmonary veins. 116-. (canceled)17. A method , comprising:identifying, via a selection module of an electrode controller, a plurality of anode/cathode pairs, each anode selected in the plurality of anode/cathode pairs being only in a first plurality of electrodes of a first multi-electrode catheter, each cathode selected in the plurality of anode/cathode pairs being only in a second plurality of electrodes of a second multi-electrode catheter, the first multi-electrode catheter and the second multi-electrode catheter configured to collectively surround a portion of a heart;conveying a pacing signal to a pacing lead configured to be operatively coupled to the heart;delivering, via a pulse delivery module of the electrode controller, a first output signal having a first polarity to each anode selected; anddelivering, via the pulse delivery module, a second output signal having a second polarity opposite the first polarity to each cathode selected, the first output signal and the second output signal being delivered according to a sequential pattern.18. The method of claim 17 , wherein the identifying is based on an input received from an input/output module of the electrode controller.19. The method of claim 17 , further comprising:computing an impedance between at least one anode electrode in the first plurality of ...

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Номер записи: 83
14-02-2019 дата публикации

Coronary sinus electrophysiology measurements device and methods

Номер: US20190046062A1
Автор: Dima Pinhasov, Lior Yankelson, Omer Shezifi
Принадлежит: Medical Research Infrastructure and Health Services Fund of the Tel Aviv Medical Center

An electrode array configured to be inserted at least partially into a blood vessel including: a self-expandable array body; at least two axially spaced-apart electrodes connected to said array body; wherein at least part of said array body expands to an open conformation and pushes at least one selected electrode against a blood vessel inner tissue with a force designed not to damage venous tissue.

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Номер записи: 84
14-02-2019 дата публикации

SYSTEMS AND METHODS FOR TREATING CANCER AND/OR AUGMENTING ORGAN FUNCTION

Номер: US20190046264A1
Автор: Schawrtz Robert S., Toth Landy
Принадлежит:

Systems, methods and devices for controlled sympathectomy procedures for neuromodulation in the treatment of subjects having neoplastic conditions are disclosed. Systems, methods, and devices for interventionally treating a cancerous tumor and cancer related pain are disclosed. 1. A medical system , comprising:a microsurgical tool configured for percutaneous introduction and having a distal tip segment positionable with respect to a target neural structure, the microsurgical tool including at least two zones adjacent the distal tip segment, at least a first of the two zones including a physiological sensor configured to emit a signal representative of physiological data of the neural structure and at least a second of the two zones including a stimulatory element configured to apply stimulation to the neural structure; and to determine a condition of the neural structure before, during or subsequent to application of stimulation to the neural structure by the stimulatory element; and', 'to control operation of the stimulatory element based on the determined condition of the neural structure., 'a controller to control operation of each of the two zones based on the physiological data obtained by the physiological sensor, the controller configured2. The medical system of claim 1 , wherein the stimulatory element of the second zone is one of: an energy delivery element; and a substance delivery element.3. The medical system of claim 2 , wherein the energy delivery element is configured to deliver energy adjacent the neural structure claim 2 , the energy being at least one of thermal energy claim 2 , radio frequency current claim 2 , microwave current claim 2 , ultrasound claim 2 , HIFU (high intensity focused ultrasound) claim 2 , radiation claim 2 , and cryotherapy.4. The medical system of claim 2 , wherein the substance delivery element is configured to deliver a substance adjacent the neural structure claim 2 , the substance being at least one of a medicament claim ...

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Номер записи: 85
25-02-2016 дата публикации

Apparatus and method for treating a neuromuscular defect

Номер: US20160051319A1
Автор: Francis A. Papay
Принадлежит: CLEVELAND CLINIC FOUNDATION

One aspect of the present disclosure relates to a treatment probe comprising an elongated body member and a needle portion. The elongated body member can have a proximal end portion and a distal end portion. The needle portion can be connected to the distal end portion. The needle portion can include at least one electrode and at least one fluid port. The at least one electrode and the at least one fluid port can be configured to deliver electrical energy and a tumescent fluid, respectively, so that superficial tissue planes overlying a target nerve are protected from inadvertent heat damage as a result of application of electrical energy to a target nerve.

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Номер записи: 86
25-02-2021 дата публикации

METHODS AND SYSTEMS FOR THERAPEUTIC NEUROMODULATION

Номер: US20210052183A1
Автор: IZVARINA Natalia
Принадлежит: Biosensor, Inc.

Systems, methods and computer-readable media are disclosed for providing therapeutic auditory stimulation. Consistent with disclosed embodiments, a system for providing therapeutic auditory stimulation may comprise a diagnostic unit that computes an EEG spectral density of a patient and a heart rate spectral density of a patient and provides values for one or more EEG frequency bands and one or more heart rate frequency bands. The system may also comprise a therapy unit that generates, based on the provided values, one or more stimulation waveforms corresponding to one or more of the EEG frequency bands and provides the stimulation waveforms for therapeutic auditory stimulation. The stimulation waveforms may comprise audible carrier frequencies modulated by signals with frequencies that vary exponentially with time. The EEG frequency bands may comprise the delta, theta, alpha, beta 1, beta 2, and gamma EEG frequency hands. 150-. (canceled)51. A device for providing therapeutic visual stimulation comprising: corresponding to electroencephalographic (EEG) frequency bands, and', 'comprising visible light carrier signals modulated by modulating signals with frequencies that vary non-linearly with time; and, 'a processor and a non-transitory memory containing instructions that when executed by the processor cause the device to generate one or more stimulation waveforms, the one or more stimulation waveformsa light source for providing at least one of the one or more stimulation waveforms to a patient as therapeutic visual stimulation;wherein the at least one of the one or more stimulation waveforms comprises pairs of frequency intervals, the pairs including increasing frequency intervals and decreasing frequency intervals, the frequencies increasing exponentially during the increasing frequency intervals and decreasing exponentially during the decreasing frequency intervals.52. The device of claim 51 , wherein:the one or more stimulation waveforms comprise a first ...

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Номер записи: 87
25-02-2021 дата публикации

Catheter with tapered support member for variable arcuate distal assembly

Номер: US20210052323A1
Автор: Jose L. Jimenez, Thomas V. Selkee
Принадлежит: Biosense Webster Israel Ltd

A catheter with a variable circular loop responsive to a contraction wire for coiling is supported by a member having a tapered distal section that transitions from a circular cross-section to a generally rectangular cross-section while maintaining a uniform cross-sectional area along the entire tapered length for improved coiling characteristics. A radially constrictive sleeve prevents separation of the contraction wire from the support member to minimize misshaping of the loop during contraction.

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Номер записи: 88
22-02-2018 дата публикации

BASKET CATHETER WITH DEFLECTABLE SPINE

Номер: US20180049803A1
Автор: Solis Mario A.
Принадлежит:

A catheter adapted for mapping and/or ablation in the atria has a basket-shaped electrode array with two or more location sensors with a deflectable expander. The catheter has comprises a catheter body, a basket electrode assembly at a distal end of the catheter body, and a control handle at a proximal end of the catheter body. The basket electrode assembly has a plurality of electrode-carrying spines and an expander that is adapted for longitudinal movement relative to the catheter body for expanding and collapsing the assembly via a proximal end portion extending past the control handle that can be pushed or pulled by a user. The expander is also adapted for deflection in responsive to an actuator on the control handle that allows a user to control at least one puller wire extending through the catheter body and the expander. 1. A method of mapping or ablating tissue in a cavernous region , the method comprising: an elongated catheter body having proximal and distal ends and at least one lumen therethrough;', 'an electrode assembly at the distal end of the catheter body, the electrode assembly having proximal and distal ends and comprising a plurality of spines, the spines comprising a plurality of electrodes;', 'an expander having proximal and distal ends, the expander forming a longitudinal axis of the assembly, the spines being attached at their proximal ends to the catheter body and at their distal ends to the expander;', 'at least one puller wire that extends through the expander, the puller wire having a distal end anchored in the expander at a location distal of the distal end of the catheter body and proximal of the distal end of the assembly; and', 'a control handle proximal of the catheter body, the control handle having an actuator adapted to move the at least one puller wire,', 'wherein the electrode assembly has an expanded arrangement when the expander is moved proximally along the longitudinal axis relative to the catheter body and the electrode ...

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Номер записи: 89
03-03-2022 дата публикации

Real-time correction of anatomical maps

Номер: US20220067923A1
Автор: Assaf COHEN, Fady Massarwa
Принадлежит: Biosense Webster Israel Ltd

A system includes an input device and a processor. The processor is configured to add, to a point cloud representing an anatomical volume, multiple points corresponding to respective locations of a probe within the anatomical volume, to remove a subset of the points from the point cloud in response to an input received via the input device, subsequently to adding the points, and to add, to the point cloud, other points corresponding to respective subsequent locations of the probe within the anatomical volume, subsequently to removing the subset. Other embodiments are also described.

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Номер записи: 90
10-03-2022 дата публикации

IRE Ablation Systems and Protocols Using a Basket Catheter

Номер: US20220071694A1
Автор: Andres Claudio Altmann, Assaf Govari, Lilah Marziano, Yuri Shamis
Принадлежит: Biosense Webster Israel Ltd

A medical apparatus includes a probe, including an insertion tube configured for insertion into a body cavity of a patient and a basket assembly, which has a proximal end that is connected distally to the insertion tube and includes a plurality of resilient spines, which are configured to bow radially outward around a longitudinal axis of the basket assembly and are conjoined at a distal end of the basket assembly. A plurality of electrodes are configured to contact tissue in the body cavity and include radial electrodes disposed on the spines and an axial electrode disposed on the longitudinal axis of the basket assembly. An electrical signal generator is configured to apply to the electrodes, including the axial electrode, pulses having an amplitude sufficient to cause irreversible electroporation (IRE) in the tissue contacted by the electrodes.

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Номер записи: 91
10-03-2022 дата публикации

Electroporation for obesity or diabetes treatment

Номер: US20220071700A1
Автор: Barham K. ABU DAYYEH, Christopher V. DESIMONE, Samuel J. Asirvatham
Принадлежит: Mayo Foundation for Medical Education and Research

Endolumenal devices and methods can be used for the treatment of health conditions including obesity and diabetes. In some embodiments, the methods and systems provided herein can cause weight loss or control diabetes by reducing the caloric absorption of an individual. For example, this document provides several devices and methods for treating obesity and diabetes by using electroporation to modulate the duodenal mucosa. In addition, this document provides devices and methods for bypassing portions of the gastrointestinal tract to reduce nutritional uptake.

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Номер записи: 92
03-03-2016 дата публикации

Electrosurgical Pericardial Puncture

Номер: US20160058504A1
Автор: Gareth Davies, John Paul Urbanski
Принадлежит: Baylis Medical Co Inc

Devices and methods for providing access to the pericardial cavity while reducing risk of myocardial damage. One method includes advancing a distal end of a puncture device towards the heart from a subxiphoid region of a patient wherein the distal end of the puncture device is atraumatic and comprises an energy delivery device; positioning the energy delivery device at a target site on a pericardium of the heart using ultrasound for imaging; and delivering energy from the energy delivery device to a tissue of the target site to create a channel to the pericardial cavity. The method may include repeating one or more of the above steps until the energy delivery device is located within the pericardial cavity. Some embodiments of the method include using supplemental means of monitoring, including medical imaging and using contrast fluid.

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Номер записи: 93
01-03-2018 дата публикации

Methods and systems for therapeutic neuromodulation

Номер: US20180055402A1
Автор: Natalia Izvarina
Принадлежит: Biosensor Inc

Systems, methods and computer-readable media are disclosed for providing therapeutic auditory stimulation. Consistent with disclosed embodiments, a system for providing therapeutic auditory stimulation may comprise a diagnostic unit that computes an EEG spectral density of a patient and a heart rate spectral density of a patient and provides values for one or more EEG frequency bands and one or more heart rate frequency bands. The system may also comprise a therapy unit that generates, based on the provided values, one or more stimulation waveforms corresponding to one or more of the EEG frequency bands and provides the stimulation waveforms for therapeutic auditory stimulation. The stimulation waveforms may comprise audible carrier frequencies modulated by signals with frequencies that vary exponentially with time. The EEG frequency bands may comprise the delta, theta, alpha, beta 1, beta 2, and gamma EEG frequency hands.

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Номер записи: 94
04-03-2021 дата публикации

Annotation histogram

Номер: US20210059548A1
Автор: Brian Stewart, Mordechai Perlman, Nathan H. Bennett, Vasiliy E. Buharin
Принадлежит: Boston Scientific Scimed Inc

Systems and methods for facilitating processing of cardiac information based on sensed electrical signals include a processing unit configured to receive a set of electrical signals; receive an indication of a measurement location corresponding to each electrical signal of the set of electrical signals; and generate, based on at least one of an annotation waveform corresponding to each electrical signal of the set of electrical signals and a set of annotation mapping values, an annotation histogram.

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Номер записи: 95
04-03-2021 дата публикации

Catheter construction to eliminate static and noise

Номер: US20210059744A1
Автор: Dustin R. Tobey, Mohammad Abbas, Raymond Yue-Sing Tang, Ricardo Padilla, JR., Steven W. WU, Yitzhak T. LEVY
Принадлежит: Biosense Webster Israel Ltd

An apparatus includes a catheter having a flexible outer sheath and a flexible irrigation tube. The flexible outer sheath defines a first lumen. The flexible irrigation tube is positioned inside the first lumen and includes an inner layer and an outer coating layer. The inner layer is formed of a synthetic polymer compound and has a uniform cross-section with a hollow interior defining a second lumen. The outer coating layer is disposed around the inner layer. The outer coating layer is formed of a polymeric compound and includes first and second isomers. The first isomer is configured to carry a positive electric charge and the second isomer is configured to carry a negative electric charge.

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Номер записи: 96
04-03-2021 дата публикации

Mapping catheter with flex panel electrode assembly

Номер: US20210059745A1
Автор: Debby E. Highsmith
Принадлежит: Biosense Webster Israel Ltd

An apparatus includes a catheter assembly and an end effector. The catheter assembly includes an outer sheath with a distal end. The end effector is associated with a distal end of the catheter assembly. The end effector includes a panel assembly with microelectrodes for electrophysiological (EP) mapping. The microelectrodes are configured in a matrix within the panel assembly and provide multiple points of contact with the target tissue for EP mapping. The panel assembly can transition between a first contracted state and a second expanded state. The panel assembly can fit within the outer sheath in the first state. The panel assembly can expand outwardly away from a longitudinal axis defined by the catheter assembly in the second state once exposed distally relative to the distal end of the outer sheath.

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Номер записи: 97
05-03-2015 дата публикации

Neuromodulation systems having nerve monitoring assemblies and associated devices, systems, and methods

Номер: US20150066006A1
Автор: Nishant R. Srivastava
Принадлежит: Medtronic Ardian Luxembourg SARL

Neuromodulation systems with nerve monitoring assemblies and associated devices, systems, and methods are disclosed herein. A neuromodulation system configured in accordance with some embodiments of the present technology can include, for example, a generator, a nerve monitoring assembly configured to detect electroneurogram (ENG) signals, and a neuromodulation catheter. The neuromodulation catheter can include an elongated shaft with a distal portion and a proximal portion. The distal portion of the shaft can include an array of electrodes configured to detect nerve activity from within a blood vessel of a human. The proximal portion of the shaft can include at least one connector that operably couples the electrodes to the generator and to the nerve monitoring assembly.

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Номер записи: 98
28-02-2019 дата публикации

MULTI-ELECTRODE MAPPING CATHETER WITH CONTINUOUS FLEX CIRCUIT

Номер: US20190059819A1
Автор: JUNG Eugene, Jung Robert S.
Принадлежит: X-RHYTHM, LLC

A multi-electrode mapping catheter for endocardial contact mapping of a heart chamber includes an expandable basket movable between a contracted configuration and a pre-shaped deployed configuration, the expandable basket including a plurality of flexible splines. Each spline includes a flex circuit and an electrode for mapping. A catheter shaft extending from the basket includes a lumen formed therethrough for receiving an ablation catheter for placement within the expandable basket. Each flex circuit includes a conductor that directly connects the proximal end of the catheter shaft to an electrode as a single continuous piece. In another embodiment, a shaft flex circuit extends along the length of the shaft and is electrically connected to a basket flex circuit. The expandable basket maintains the electrodes in direct contact with the wall of the heart while accommodating wall motion of the beating heart during mapping and can continually map while ablating. 1. A multi-electrode mapping catheter for endocardial contact mapping of a heart chamber of a patient , the mapping catheter comprising:a flexible elongated catheter shaft having a proximal end and a distal end;a connector attached to the proximal end of the catheter shaft and adapted to be coupled to instruments outside the mapping catheter;an expandable mapping basket located at the distal end of the catheter shaft, the expandable mapping basket including a plurality of spaced-apart flexible splines, each flexible spline including a flex circuit affixed to a support layer made from a flexible substrate material, the flexible substrate material being resilient and shaped to bow outwardly to bias the basket to an expanded configuration for deployment for mapping by which the expandable mapping basket maintains the flex circuit in contact with the wall of the heart while accommodating wall motion of the beating heart;wherein each flex circuit includes a first layer having a plurality of electrodes formed ...

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Номер записи: 99
28-02-2019 дата публикации

CHEMICAL MODULATION OF NERVES INNERVATING THE LIVER

Номер: US20190059969A1
Автор: Azamian Bobak Robert, Vafai Scott Bradley
Принадлежит:

According to some embodiments, a method of treating a subject having diabetes or symptoms associated with diabetes is provided. The method includes delivering a neuromodulation catheter within a vessel (e.g., hepatic artery) having surrounding nerves that innervate the liver (e.g., sympathetic nerves of the hepatic plexus). The method may also include modulating (e.g., disrupting, ablating, stimulating) the nerves by mechanical compression, energy delivery, or fluid delivery. 1. (canceled)2. A method of altering glucose levels , the method comprising:inserting a catheter into a vasculature of a subject,wherein said catheter comprises a distal end configured to disrupt one or more nerves,advancing the distal end of the catheter to a location within a portion of a common hepatic artery of the vasculature; anddisrupting one or more nerves of a hepatic plexus surrounding the portion of the common hepatic artery to decrease a glucose level within the subject.3. The method of claim 2 , wherein the distal end comprises a cutting portion configured to transect said one or more nerves.4. The method of claim 2 , wherein the distal end comprises a compression member configured to apply mechanical compression to disrupt the one or more nerves.5. The method of claim 4 , wherein the compression member comprises a shape memory compression clip.6. The method of claim 4 , wherein the compression member comprises a vascular wall clamp.7. The method of claim 6 , wherein the catheter comprises a plurality of suction holes configured to create suction on a wall surface of the common hepatic artery.8. The method of claim 2 , wherein the distal end is configured to hold a cooling fluid configured to cryogenically disrupt said one or more nerves.9. The method of claim 8 , wherein the distal end comprises a balloon.10. The method of claim 2 , wherein the distal end comprises a delivery portion configured to deliver a chemoablative agent to ablate said one or more nerves.11. The method of ...

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Номер записи: 100