ОБТУРИРУЮЩЕЕ УСТРОЙСТВО И СИСТЕМА ПОДАЧИ

... 1. Медицинское устройство, содержащее:множество удлиненных элементов, расположенных таким образом, что они определяют раму медицинского устройства, причем рама включает в себя проксимальное ушко, рядом с первым продольным концом устройства, дистальное ушко, рядом со вторым продольным концом устройства, проксимальную колбу и дистальную колбу, при этом проксимальная колба и дистальная колба, каждая, расположены между первым ушком и вторым ушком, причем дистальная колба включает в себя множество лепестков;уплотнительный элемент, который покрывает по меньшей мере часть рамы медицинского устройства; ипо меньшей мере один анкер, прикрепленный по меньшей мере к одному из лепестков дистальной колбы, при этом по меньшей мере один анкер включает в себя первый отрезок и второй отрезок, причем по меньшей мере часть первого отрезка ориентирована, по существу, параллельно части второго отрезка, при этом первый отрезок и второй отрезок сходятся на петлеобразном конце по меньшей мере одного анкера.2. Устройство ...

КРЮЧКИ ДЛЯ ФИКСАЦИИ МЕДИЦИНСКОГО УСТРОЙСТВА

... 1. Имплантируемое медицинское устройство, содержащеекаркас, имеющий, по меньшей мере, один продолговатый элемент, ификсирующий элемент, содержащий первую манжету, вторую манжету, зацепляющийся с тканью элемент, конфигурация которого обеспечивает крепление к ткани на участке имплантации для удержания имплантируемого медицинского устройства в положении, которое находится на участке имплантации, и соединяющий манжеты элемент, имеющий дуговую форму и соединенный у первого края с первой манжетой, а у второго края со второй манжетой,отличающееся тем, чтопервая манжета окружает периметр первого участка, по меньшей мере, одного продолговатого элемента, вторая манжета окружает периметр второго участка, по меньшей мере, одного продолговатого элемента, а соединяющий манжеты элемент не окружает периметр ни одного участка, по меньшей мере, одного продолговатого элемента.2. Имплантируемое медицинское устройство по п. 1, отличающееся тем, что зацепляющийся с тканью элемент имеет конфигурацию, обеспечивающую ...

DIVERSON DEVICE FOR THE INCREASE OF THE BRAIN BLOOD CIRCULATION

SEALING SYSTEM FOR AN OPEN FORAMEN OVALS

Devices for occlusion of an atrial appendage

Various aspects of the present disclosure are directed toward apparatuses, methods, and systems as relating to occlusion. In certain instances, the apparatuses, methods, and systems may include a device for placement in vessels, appendages, and openings in a body. The device may include a unitary frame having a face portion that includes a center frame portion a plurality of elongate members.

Occlusive devices

An occlusive device includes a frame element having a distal end and a proximal end, and a delivery configuration and a deployed configuration. The occlusive device also includes an occlusive face having a peripheral edge, where the occlusive face positioned toward the proximal end of the frame element. The occlusive device also includes at least one anchor positioned at the peripheral edge of the occlusive face, where the at least one anchor extends at an acute angle to the peripheral edge of the occlusive face. 7952715_1 (GHMatter) P96297.AU.1 P, 1100 A< ...

Device for preventing clot migration from left atrial appendage

DEVICE FOR PREVENTING CLOT MIGRATION FROM LEFT ATRIAL A device (10) for placement within the left atrial appendage of a patient comprising a retention member (12) and a material (30) positioned within the retention member (12) and unattached thereto. The retention member (12) has a first elongated configuration for delivery and a second expanded configuration for placement within the io left atrial appendage. The material (30) is configured to float within the retention member (12). The retention member (12) can have at least one appendage wall engagement member to secure the retention member (12) to the appendage. KslQ ...

ADJUSTABLE LEFT ATRIAL APPENDAGE OCCLUSION DEVICE

An adjustable occlusion device (10) for use in occluding a body lumen, such as a left atrial appendage. The occlusion device is carried by a deployment catheter (238). The device may be enlarged or reduced to facilitate optimal placement or removal.

INFLATABLE DEVICES FOR ENTERIC FISTULA TREATMENT

Disclosed herein is an implantable fistula closure device. The device may include an expandable longitudinally segmented body including a proximal end and a distal end. The segmented body may further include a plurality of porous bodies and a connecting member operably joining together the plurality of porous bodies. The plurality of porous bodies includes a first porous body with a proximal end and a distal end and a second porous body with a proximal end and a distal end, and the connecting member operably connects the proximal end of the first porous body with the distal end of the second porous body.

A SYSTEM FOR IMPROVING CARDIAC FUNCTION

A system for improving cardiac function is provided. A foldable and expandable frame having at least one anchoring formation is attached to an elongate manipulator and placed in a catheter tube while folded. The tube is inserted into a left ventricle of a heart where the frame is ejected from the tube and expands in the left ventricle. Movements of the elongate manipulator cause the anchor to penetrate the heart muscle and the elongate manipulator to release the frame. The installed frame minimizes the effects of an akinetic portion of the heart forming an aneurysmic bulge.

VASCULAR IMPLANT WITH ANCHOR MEMBER

An expandable vascular implant is disclosed, which comprises a framework with openings and forming an exterior surface of the implant, and at least one anchor member for anchoring the implant to a vascular structure and having a proximal portion and a distal portion. The distal portion of the anchor member comprises at least one free end configured to extend outwardly from the framework. The anchor member is at least partly interlaced with the framework between the proximal portion and the distal portion such that the anchor member is fixed to the framework.

SEALING DEVICE AND DELIVERY SYSTEM

SINGLE DISC OCCLUSIONARY PATENT FORAMEN OVALE CLOSURE DEVICE

The present invention is a method and device for closing a passageway in a body, for example a patent foramen ovale (PFO) in a heart, and related methods of using such closure devices for closing the passageway.

IMPLANTABLE MEDICAL DEVICE DEPLOYMENT SYSTEM

A medical device delivery system includes an implantable medical device and a delivery device. The implantable medical device includes at least one attachment feature having an elastomeric element. The delivery device includes a catheter and an elongate element. The catheter is arranged to contact the elastomeric element, and the elongate element is arranged to releasably couple with the elastomeric element.

JOINT ASSEMBLY FOR MEDICAL DEVICES

A device (100) for occluding an aperture in a body of a patient includes a frame (110) that includes a plurality of elongate members (111) and a hub component (102) that includes a plurality of attachment members (150), wherein for each elongate member of the plurality of elongate members a first end of the elongate member is fixedly attached to an attachment member of the plurality of attachment members at an attachment region. The frame and the hub component together form at least one occlusive element. Each receptacle of the plurality of attachment members is configured to pivot with respect to the hub component, such that each attachment region is movable with respect to the hub component.

SPACE FILLING DEVICES

A device frame includes a plurality of elongate frame members, first and second hub members substantially aligned along a longitudinal axis of the device frame, and a coupling element that couples the first hub member to the second hub member. The device frame includes a face section, a laterally facing skirt section, and an inverted section. First portions of the elongate members define the face section and extend radially from the first hub member. Second portions of the elongate members define the laterally facing skirt section and extend in a distal, axial, and helical direction along a first rotational direction from the face section. Third portions of the elongate members define the inverted section and extend in a generally proximal direction from a distal portion of the laterally facing skirt section to the second hub member along a rotational direction opposite the first rotational direction.

MEDICAL DEVICE FIXATION ANCHORS

An implantable medical device (100) includes a frame that includes at least one elongate member (120). The implantable medical device also includes a fixation member (200) comprising a first cuff (210), a second cuff (220), a tissue engagement member (230) configured to anchor to tissue at an implant site to thereby hold the implantable medical device in a position at the implant site, and a cuff (240) joining member comprising an arcuate shape and connected at a first end to the first cuff and at a second end to the second cuff. The first cuff substantially surrounds a perimeter of a first portion of the at least one elongate member, the second cuff substantially surrounds a perimeter of a second portion of the at least one elongate member, and the cuff joining member does not substantially surround a perimeter of any portion of the at least one elongate member.

OCCLUSIVE DEVICES WITH ANCHORS EXTENDING FROM PERIPHERAL EDGE OF THE OCCLUSIVE FACE

An occlusive device (100) includes a frame element (102) having a distal end (112) and a proximal end (110), and a delivery configuration and a deployed configuration. The occlusive device also includes an occlusive face (106) having a peripheral edge (114), where the occlusive face positioned toward the proximal end of the frame element. The occlusive device also includes at least one anchor (50) positioned at the peripheral edge of the occlusive face, where the at least one anchor extends at an acute angle to the peripheral edge of the occlusive face.

DEVICES AND METHODS FOR OCCLUDING ABNORMAL OPENINGS IN A PATIENT'S VASCULATURE

A medical device (100) is provided in which one or both ends of the device encourage the formation of tissue across substantially the entire area of the respective end that is exposed to the blood flow for reducing the risk of a thrombotic embolism. The medical device includes a tubular structure (130) having at least one expanded volume portion (180) and a tapered transition portion (190). The tubular structure may be made through the braiding of a number of strands, and a first end feature (140) may be used to secure the proximal strand ends. The proximal strand ends may be secured via the proximal end of the first end feature, such that the tapered transition portion is formed over the circumferential surface of the first end feature, and only a proximal end surface (or a portion of the proximal end surface) of the first end feature is exposed to the path of flowing blood.

DEVICES AND METHODS FOR OCCLUDING OR PROMOTING FLUID FLOW

Devices and methods for occluding or promoting fluid flow through openings are disclosed. In one exemplary embodiment an occlusion device (10) is provided having an expandable outer elongate tubular body (20), a guide member (30) extending from a distal end (20d) of the outer body, and a slide tube (40) disposed within the outer body, the proximal portions (20p,40p) of the outer body and the slide tube being fixedly mated. The slide tube is configured to slide distally within the outer tubular body when the tubular body is expanded to form wings (24a, 24b). A tether (60) can be included as part of the device and it can be used to assist in positioning and locking a location of the device in an opening. Exemplary methods for delivering devices disclosed herein are also provided.

TISSUE CLOSURE DEVICE AND METHOD

METHOD FOR TREATING MYOCRADIAL RUPTURE

A method and device for the treatment of a patient with heart disease and particularly a heart chamber having a myocardial rupture or characteristics of an incipient myocardial rupture. The heart chamber is partitioned so as to isolate a non-productive portion having a rupture or a region of an incipient rupture from a productive portion. The heart chamber is preferably partitioned with a reinforced membrane which has a pressure receiving surface that defines part of the productive portion of the heart chamber. The peripheral base of the reinforced membrane may have an eccentric configuration.

System and method for transapical access and closure

Embodiments are described for creating and closing tissue access ports, such as transapical access ports, which involve placement of an introducer across the subject tissue structure, and deployment of a controllable port closure device assembly configured to remain in place with a ratcheting mechanism, and to hold the tissue surrounding the previous access port location closed against a sealing disc with proximal and distal strut assemblies, after the introducer has been removed.

Intracardiac cage and method of delivering same

A method of preventing ingress of material into the left atrium of a heart includes providing a delivery sheath, advancing the sheath distal end through an opening between the right atrium and the left atrium of the heart, providing an expandable cage, delivering the expandable cage to the left atrium, and expanding the expandable cage within the left atrium. The expandable cage includes a proximal end, a distal end, and a plurality of supports extending therebetween. The expandable cage also includes a first membrane provided at its proximal end and a second membrane provided at its distal end. The expandable cage has a collapsed configuration so that it can be received within the lumen of the delivery sheath, and an expanded configuration for deployment within the heart. When expanded, the first membrane is positioned at an opening between the left and right atria of the heart, and the second membrane is positioned at the ostium of the left atrial appendage. The first membrane substantially ...

Method and device for left atrial appendage occlusion

A device and method for obliterating or occluding a body cavity or passageway, in particular, the left atrial appendage of a patient's heart. The procedure can be carried out intraoperatively, but is preferably carried out percutaneously by use of a delivery catheter to position an occluding device adjacent a patient's left atrial appendage. The occluding device may prevent the passage of embolic or other material to or from the left atrial appendage by volumetrically filling the appendage, closing the opening of the appendage with an occluding member, or pulling the tissue around the opening of the appendage together and fixing it in a closed state.

Closing plug of a defect for medical use and a closing plug device utilizing it

The closing plug and the closing plug device are used for closing a body defect percutaneously. During the insertion into the defect, the closing plug can be deformed to a smaller size to facilitate the insertion operation and recovered to its original larger shape after it is fitted to the defect, to thereby close the defect. The closing plug device facilitates the insertion of the closing plug into the defect. The closing plug has a flange or an enlarged portion at least at one end thereof and is made of a shape memory polymer having a shape recovery temperature in the range of 20° C. to 70° C. The closing plug device comprises a closing plug, a catheter and a guide wire or a pushing wire to aid in insertion of the closing plug to a defect.

Needle apparatus for closing septal defects and methods for using such apparatus

Apparatus and methods for closing a septal defect including a flap of tissue partially detached from a septum of a heart. A needle is advanced through a patient's vasculature within a delivery apparatus until the needle is disposed within a first chamber adjacent the septum. The needle is directed through the flap of tissue until the needle is disposed within a second chamber opposite the septum. A filament attached to an intermediate region of the needle is pulled, thereby causing the needle to pivot about the intermediate region such that the ends of the needle straddle the septal opening. A locking element is secured to the filament to secure the flap of tissue against the septum, and the filament is cut. Alternatively, the filament is biased to coil to engage the flap of tissue and secure the needle against the septum to close the opening.

Fixation device and methods for engaging tissue

The invention provides devices, systems and methods for tissue approximation and repair at treatment sites. The devices, systems and methods of the invention will find use in a variety of therapeutic procedures, including endovascular, minimally-invasive, and open surgical procedures, and can be used in various anatomical regions, including the abdomen, thorax, cardiovascular system, heart, intestinal tract, stomach, urinary tract, bladder, lung, and other organs, vessels, and tissues. The invention is particularly useful in those procedures requiring minimally-invasive or endovascular access to remote tissue locations, where the instruments utilized must negotiate long, narrow, and tortuous pathways to the treatment site. In addition, many of the devices and systems of the invention are adapted to be reversible and removable from the patient at any point without interference with or trauma to internal tissues.

Methods And Apparatus For Cardiac Valve Repair

The methods, devices, and systems are provided for performing endovascular repair of atrioventricular and other cardiac valves in the heart. Regurgitation of an atrioventricular valve, particularly a mitral valve, can be repaired by modifying a tissue structure selected from the valve leaflets, the valve annulus, the valve chordae, and the papillary muscles. These structures may be modified by suturing, stapling, snaring, or shortening, using interventional tools which are introduced to a heart chamber. Preferably, the tissue structures will be temporarily modified prior to permanent modification. For example, opposed valve leaflets may be temporarily grasped and held into position prior to permanent attachment.

Devices and methods for occluding abnormal openings in a patient's vasculature

A medical device is provided in which one or both ends of the device encourage the formation of tissue across substantially the entire area of the respective end that is exposed to the blood flow for reducing the risk of a thrombotic embolism. The medical device includes a tubular structure having at least one expanded volume portion and a tapered transition portion. The tubular structure may be made through the braiding of a number of strands, and a first end feature may be used to secure the proximal strand ends. The proximal strand ends may be secured via the proximal end of the first end feature, such that the tapered transition portion is formed over the circumferential surface of the first end feature, and only a proximal end surface (or a portion of the proximal end surface) of the first end feature is exposed to the path of flowing blood.

FIXATION DEVICES, SYSTEMS AND METHODS FOR ENGAGING TISSUE

The invention provides devices, systems and methods for tissue approximation and repair at treatment sites. The devices, systems and methods of the invention will find use in a variety of therapeutic procedures, including endovascular, minimally-invasive, and open surgical procedures, and can be used in various anatomical regions, including the abdomen, thorax, cardiovascular system, heart, intestinal tract, stomach, urinary tract, bladder, lung, and other organs, vessels, and tissues. The invention is particularly useful in those procedures requiring minimally-invasive or endovascular access to remote tissue locations, where the instruments utilized must negotiate long, narrow, and tortuous pathways to the treatment site. In addition, many of the devices and systems of the invention are adapted to be reversible and removable from the patient at any point without interference with or trauma to internal tissues.

Fixation device delivery catheter, systems and methods of use

Devices, systems, methods and kits are provided for delivering interventional devices to a target location with a body. Such interventional devices particularly include fixation devices or any devices which approximate tissue, such as valve leaflets. The delivery devices and systems direct the interventional device to the target location through a minimally invasive approach, such as through the patient's vasculature, and provide for manipulation of the interventional device at the target location, such as to approximate tissue. Optionally, the delivery devices and systems may provide for decoupling of the interventional device, allowing the interventional device to be left behind as an implant.

Method of implanting an adjustable occlusion device

Disclosed is an adjustable occlusion device for use in a body lumen such as the left atrial appendage. The occlusion device is removably carried by a deployment catheter. The device may be enlarged or reduced to facilitate optimal placement or removal. Methods are also disclosed.

Patent foramen ovale closure system

Devices and methods are disclosed herein for closing a patent foramen ovale. The devices are deployed at the foramen ovale to secure the septum secundum and septum primum together, thus sealing the foramen ovale. Disclosed are devices that may be inserted through a piercing in the septum secundum and septum primum to secure the septa together. Also disclosed is a delivery device to be used in connection with the devices and methods described. In some embodiments, the devices include an expandable member that secures at least one side of either the septum secundum or septum primum to secure the two septa together.

Medical device for modification of left atrial appendage and related systems and methods

A medical device and system for modifying a left atrial appendage (“LAA”), as well as related methods, are provided. In accordance with one embodiment, a medical device includes a plurality of frame segments coupled with at least one ring member, the at least one ring member having an inner surface defining notches radially spaced therein, each of the frame segments configured to be positioned within one of the notches of the at least one ring member to collectively form a frame structure. Each frame segment includes a hub portion and at least one leg portion, the hub portion having an upper surface configured to be captured in one of the notches defined in the at least one ring member, and the at least one leg portion extending from the hub portion. With this arrangement, a tissue growth member is coupled to the frame segments.

METHODS, SYSTEMS AND DEVICES FOR REDUCING THE SIZE OF AN INTERNAL TISSUE OPENING

MEDICAL DEVICES HAVING FIXATION ANCHOR

УСТРОЙСТВА, СИСТЕМЫ И СПОСОБЫ СЦЕПЛЕНИЯ С ТКАНЬЮ

... 1. Фиксатор, содержащий:основной участок, имеющий, по существу, трубчатую форму и образующий просвет, имеющий центральную линию, причем основной участок содержит участок сцепления; имножество лапок фиксатора с памятью формы, присоединенных к основному участку таким образом, чтобы множество лапок фиксатора с памятью формы, по существу, были параллельны центральной оси основного участка, причем каждая из множества лапок фиксатора с памятью формы состоит из проникающего в ткань острого конца, присоединенного к копьевидному участку и поддерживаемого копьевидным участком, который выполнен с возможностью выворачиваться при развертывании,при этом каждый из копьевидных участков выполнен с возможностью выворачиваться в направлении от центральной оси основного участка при развертывании.2. Фиксатор по п. 1, который состоит из материала с памятью формы.3. Фиксатор по п. 1, который дополнительно содержит один расходящийся на конус сегмент.4. Фиксатор по п. 1, который дополнительно содержит гребневый ...

BLOCKAGE DEVICE

ADJUSTABLE VERSCHLUSSVORRICHTUNG FOR LINKING APPENDIX OF FORECOURT

PROCEDURE AND DEVICE FOR HERZKLAPPENREPERATION

SEALING SYSTEM FOR A PATENT FORAMENOVAL

Method for treating myocradial rupture

Method and device for cavity obliteration

Capturing and fixing leaflets in valve repair

Single disc intraluminal patent foramen ovale closure device

Devices for occlusion of an atrial appendage

Various aspects of the present disclosure are directed toward apparatuses, methods, and systems as relating to occlusion. In certain instances, the apparatuses, methods, and systems may include a device for placement in vessels, appendages, and openings in a body. The device may include a unitary frame having a face portion that includes a center frame portion a plurality of elongate members.

Implantable medical device deployment system

A medical device delivery system includes an implantable medical device and a delivery device. The implantable medical device includes at least one attachment feature having an elastomeric element. The delivery device includes a catheter and an elongate element. The catheter is arranged to contact the elastomeric element, and the elongate element is arranged to releasably couple with the elastomeric element.

METHOD AND DEVICE FOR LEFT ATRIAL APPENDAGE OCCLUSION

This invention is an occlusion device (10) for use in a body lumen such as the left atrial appendage (31). The occlusion device includes an occlusion member (11), and may also include a stabilizing member (12). The stabilizing member inhibits compression of the left atrial appendage, facilitating tissue ingrowth onto the occlusion member. The method of making the device includes forming a plurality of slots in a tube, the slots creating radially outwardly biased longitudinal elements (228). A membrane barrier (15) is then attached to the elements.

A SYSTEM FOR IMPROVING CARDIAC FUNCTION

... ²²²A system for improving cardiac function is provided. A foldable and expandable ²frame having at least one anchoring formation is attached to an elongate ²manipulator and placed in a catheter tube while folded. The tube is inserted ²into a left ventricle of a heart where the frame is ejected from the tube and ²expands in the left ventricle. Movements of the elongate manipulator cause the ²anchor to penetrate the heart muscle and the elongate manipulator to release ²the frame. The installed frame minimizes the effects of an akinetic portion of ²the heart forming an aneurysmic bulge.² ...

METHOD AND DEVICE FOR LEFT ATRIAL APPENDAGE OCCLUSION

This invention is an occlusion device (10) for use in a body lumen such as the left atrial appendage (31). The occlusion device includes an occlusion member (11), and may also include a stabilizing member (12). The stabilizing member inhibits compression of the left atrial appendage, facilitating tissue ingrowth onto the occlusion member. The method of making the device includes forming a plurality of slots in a tube, the slots creating radially outwardly biased longitudinal elements (228). A membrane barrier (15) is then attached to the elements.

METHODS AND APPARATUS FOR CARDIAC VALVE REPAIR

The methods, devices, and systems are provided for performing endovascular repair of atrioventricular and other cardiac valves in the heart. Regurgitation of an atrioventricular valve, particularly a mitral valve, can be repaired by modifying a tissue structure selected from the valve leaflets, the valve annulus, the valve chordae, and the papillary muscles. These structures may be modified by suturing, stapling, snaring, or shortening, using interventional tools (30, 36, 56) which are introduced to a heart chamber. Preferably, the tissue structures will be temporarily modified prior to permanent modification. For example, opposed valve leaflets may be temporarily grasped and held into position prior to permanent attachment.

APICAL PUNCTURE ACCESS AND CLOSURE SYSTEM

A device, system, and method for providing access to, and sealing of, a body organ includes an implant device. An implant device has a main body having an internal access lumen, with a plurality of prongs extending from a distal end of the main body. The main body can include two lumens, one slidable within the other, to form a single continuous lumen with an adjustable length. The main body has an expanded configuration with an expanded diameter, and an unexpanded configuration with an unexpanded diameter. The prongs have a generally straight configuration where they extend distally of the distal end of the main body, and a bent configuration where the prongs bend around so that their tips extend proximally of the distal end of the main body. The device may include a hemostatic barrier to prevent fluid leakage therethrough when the main body is in the unexpanded configuration.

LEFT ATRIAL APPENDAGE CLOSURE DEVICE

Disclosed is a left atrial appendage closure device, comprising a closure plate (106) and an anchor plate (101) connected to the closure plate (106). The closure plate (106) is in a mesh structure and is internally provided with a flow resisting film (108). The distal end of the closure plate (106) is fixed by a tubular member (109). The tubular member (109) is provided with a plurality of support rods (102) with respect to the other end of the closure plate (106). The support rods (102) are emitted from the direction relative to the closure plate (106). The proximal end of the support rod (102b) spans from the center of the tubular member (109) to the opposite side. A plurality of the support rods (102) are arranged in a cross radial shape to form the anchor plate (101). An angle with a specific angle is formed between the proximal end of the support bar (102b) and the central axis of the tubular member (109). The closure device also comprises a modified flow resisting film, improves biocompatibility ...

TISSUE CLOSURE DEVICE AND METHOD

A device that, when implanted in the heart, closes the wound and complies with wall motion (i.e., expands and contracts with the myocardium).

DEVICES AND METHODS FOR OCCLUSION OF AN ATRIAL APPENDAGE

Various aspects of the present disclosure are directed toward apparatuses, methods, and systems as relating to occlusion. In certain instances, the apparatuses, methods, and systems may include a device for placement in vessels, appendages, and openings in a body. The device may include a unitary frame having a face portion that includes a center frame portion a plurality of elongate members.

SEALING DEVICE AND DELIVERY SYSTEM

A medical device for sealing a defect in a body includes a wire frame that includes a plurality of wires that form a first occluding member and a second occluding member. In some embodiments, a sealing member is in contact with the wire frame. In some embodiments, the sealing member is configured to define one or more openings in the sealing member.

SINGLE DISC INTRALUMINAL FIXATION PATENT FORAMEN OVALE CLOSURE DEVICE

A device and method for deploying a mechanical closure device for closing a passageway in a body, for example a patent foramen ovale (PFO) in a heart. The single disc mechanical closure device is comprise of a distal and proximal anchor constrained by a closure line to facilitate mechanical closure by bringing the distal and proximal anchors into close proximity along the closure line.

DEVICE FOR PREVENTING CLOT MIGRATION FROM LEFT ATRIAL APPENDAGE

A device for placement within the left atrial appendage of a patient comprising a retention member and a material positioned within the retention member and unattached thereto. The retention member has a first elongated configuration for delivery and a second expanded configuration for placement within the left atrial appendage. The material is configured to float within the retention member. The retention member can have at least one appendage wall engagement member to secure the retention member to the appendage.

INFLATABLE DEVICES FOR ENTERIC FISTULA TREATMENT

Disclosed herein is an implantable fistula closure device. The device may include an expand-able longitudinally segmented body including a proximal end and a distal end. The segmented body may fur-ther include a plurality of porous bodies and a connecting member op-erably joining together the plurality of porous bodies. The plurality of porous bodies includes a first porous body with a proximal end and a dis-tal end and a second porous body with a proximal end and a distal end, and the connecting member operably connects the proximal end of the first porous body with the distal end of the second porous body.

DEVICES, SYSTEMS, AND METHODS FOR OCCLUDING A DEFECT

A method of occluding a defect in a patient is provided. The method includes inserting a placement member, such as a wire guide, into a defect; advancing the placement member to a desired location; inserting the placement member into a lumen in an occluding member, such as a plug or a graft; and advancing the occluding member to the desired location by inserting the placement member into a lumen in a pusher member and pushing the occluding member with the pusher member until the occluding member reaches the desired location. Medical devices and systems for occluding defects are also provided.

SYSTEM AND METHOD FOR TRANSAPICAL ACCESS AND CLOSURE

Embodiments are described for creating and closing tissue access ports, such as transapical access ports, which involve placement of an introducer across the subject tissue structure, and deployment of a controllable port closure device assembly configured to remain in place with a ratcheting mechanism, and to hold the tissue surrounding the previous access port location closed against a sealing disc with proximal and distal strut assemblies, after the introducer has been removed.

MEDICAL DEVICES HAVING FIXATION ANCHOR

A medical device (100) including a medical device body (206) that includes a first support structure (212), the medical device further comprising a first fixation anchor (302) that includes a first anchor body extending between a first end (304) and an opposing second end (306), and a hook portion (318) extending from the first end, wherein the first anchor body engages the first support structure, and wherein the first fixation anchor is fabricated separate and apart from the medical device body. A method of making a medical device is disclosed.

SPACE FILLING DEVICES

A device (100) includes a plurality of elongate members (102), an occlusive component (112), and a support component (114). The occlusive component includes a plurality of first features each defined by a first portion of a respective elongate member. The support component includes a plurality of second features each defined by a second portion of the respective elongate member. A first termination element (108) is defined by proximal end portions of the plurality of elongate members and located near a proximal end of the device, and a second termination element (106) is defined by distal end portions of the plurality of elongate members and located near a distal end of the device. One or more anchor elements (110) include a frame attachment portion and an anchor portion, the frame attachment portion including a first portion of a fixation elongate element wrapped around an elongate member, and the anchor portion including an anchor feature.

TISSUE CLOSURE DEVICE AND METHOD

A device having a plurality of anchors configured to be driven into a tissue, an a closure element extending between the anchors and configured to urge the anchors from a first configuration in which the anchors are a first distance from each other, toward a second configuration in which the anchors are a second distance from each other, the second distance being less than the first distance, wherein the device is configured to maintain the anchors in the first configuration during a surgical intervention and to subsequently allow the anchors to be moved by the closure element toward the second configuration.

FISTULA TREATMENT DEVICES AND METHODS

Disclosed herein are implantable fistula treatment devices and methods. In some embodiments, a distal anchor for an implantable fistula treatment device may comprise a suture and multiple foldable members including at least a distal-most foldable member and a proximal-most foldable member. The distal-most foldable member may comprise a suture attachment structure. The proximal-most foldable member may be configured to couple to a surface of a body lumen at a distal opening of a fistula.

SYSTEM AND METHOD FOR DELIVERING A LEFT ATRIAL APPENDAGE CONTAINMENT DEVICE

A method of delivering and deploying the device for containing the emboli during a surgical procedure proximate to the heart. Access is gained to the heart and the left atrium such that a distal end of the delivery sheath can be located near the left atrial appendage. A distal end of a delivery catheter can be loaded with the device in a collapsed position and passed through the delivery sheath thereby delivering the device within the left atrial appendage. The device is expanded to contain emboli in the left atrium appendage.

METHODS AND DEVICES FOR ALTERING BLOOD FLOW THROUGH THE LEFT VENTRICLE

An element (6) is expanded in the left ventricle to isolate part of the left ventricle. The element has a generally convex outer surface (16) and an apex (18) which together define a desired geometry of the left ventricle. The isolated part of the wall of the left ventricle may be left so that the wall naturally forms around the element or the isolated portion of the ventricle may be evacuated and/or filled. The element may also be used to isolate part of the left ventricle containing a ventricular septal defect or other perforation or opening in the ventricular wall.

Devices for less-invasive intracardiac interventions

Devices, systems, and methods are provided for accessing the interior of the heart and performing procedures therein while the heart is beating. In one embodiment, a tubular access device having an inner lumen is provided for positioning through a penetration in a muscular wall of the heart, the access device having a means for sealing within the penetration to inhibit leakage of blood through the penetration. The sealing means may comprise a balloon or flange on the access device, or a suture placed in the heart wall to gather the heart tissue against the access device. An obturator is removably positionable in the inner lumen of the access device, the obturator having a cutting means at its distal end for penetrating the muscular wall of the heart. The access device is preferably positioned through an intercostal space and through the muscular wall of the heart. Elongated instruments may be introduced through the tubular access device into an interior chamber of the heart to perform procedures ...

Diversion device to increase cerebral blood flow

Methods and devices provide for temporary partial aortic occlusion to achieve diversion of blood flow to the brain in patients suffering from cerebral ischemia. The device includes an expandable frame and membrane that is inserted into the aorta to partially occlude blood flow.

Adaptive devices and methods for endoscopic wound closures

This invention is directed to devices and methods for improving wound closures produced during endoscopic surgery. These methods are directed to delivering and applying a quantity of hemostatic agents in either powder, solid, liquid, or gel form onto an open wound produced e.g., by polyp removal, followed by the application of pressure. The method is implemented preferably using existing endoscopic equipment; however, modifications to existing endoscopic insertion tubes, application and tamping devices and endoscopic clips deployed from the distal end of the insertion tube during endoscopic surgery are also within the scope of this invention.

SYSTEM AND METHOD FOR TRANSAPICAL ACCESS AND CLOSURE

Embodiments are described for creating and closing tissue access ports, such as transapical access ports, which involve placement of an introducer across the subject tissue structure, and deployment of a controllable port closure device assembly configured to remain in place with a ratcheting mechanism, and to hold the tissue surrounding the previous access port location closed against a sealing disc with proximal and distal strut assemblies, after the introducer has been removed.

Endoscopic Hemostasis Closure Device And Delivery System

A device for inserting a medical apparatus into a living body includes a handle and an elongated sheath extending from the handle to a distal end configured for insertion to a target location in the living body in combination with a clasp positioned within a distal portion of the elongated sheath and configured to temporarily attach to an endoscopic device and a spring retention mechanism movable from a first resting configuration maintaining a first closed position of the clasp to a second compressed configuration moving the clasp to an open position. A withdrawal mechanism is movable from a first resting configuration in which the distal end of the elongated sheath extends distally over a distal end of the endoscopic device to a second retracted configuration in which the distal end of the elongated sheath is moved proximally of the distal end of the endoscopic device. 125-. (canceled)26. A tissue clipping system , comprising:an elongated sheath extending from a proximal end to a distal end configured for insertion to a target location in the living body;a tissue clip comprising first and second legs extending distally from a base portion, each of the first and second legs including first and second elongated portions coupled to one another via a first hinge to permit angling of the first and second elongated portions relative to one another; anda clasp positioned within a distal portion of the elongated sheath and configured to releasably grasp the base portion of the tissue clip, the clasp comprising first and second arms configured to be movable from a closed configuration to an open configuration.27. The system of claim 26 , wherein the first and second elongated portions are coupled to one another by a pivot joint permitting angling of each of the elongated portions at any angle.28. The system of claim 26 , wherein the tissue clip is biased toward an open configuration in which each of the first and second legs extends transverse to a longitudinal axis of the ...

Detachable atrial appendage occlusion balloon

Disclosed is an adjustable occlusion device for use in a body lumen such as the left atrial appendage. The occlusion device is removably carried by a deployment catheter. The device may be enlarged or reduced to facilitate optimal placement or removal. Methods are also disclosed.

ОБТУРАТОРНЫЕ УСТРОЙСТВА

... 1. Устройство обтураторное, содержащее:каркасный элемент, имеющий внешний край и внутренний край, транспортную конфигурацию и развернутую конфигурацию; иобтураторную грань, имеющую периферическую кромку,обтураторная кромка ориентирована в сторону внутреннего края каркасного элемента; и,по меньшей мере,, один якорь, расположенный на периферической кромке обтураторной грани; и,по меньшей мере,, один якорь, идущий под прямым углом к периферической кромке обтураторной грани.2. Устройство обтураторное по п. 1, в котором, по меньшей мере, один якорь содержит зацепляющийся с тканью элемент, который выступает во внутреннем направлении относительно осевого размера устройства.3. Устройство обтураторное по п. 1, в котором, по меньшей мере, один якорь содержит зацепляющийся с тканью элемент, который выступает во внешнем направлении относительно осевого размера устройства.4. Устройство обтураторное по п. 1, в котором, по меньшей мере,, один якорь включает зацепляющийся с тканью элемент, который проходит ...

МЕДИЦИНСКИЙ ИМПЛАНТАТ

Verschlusssystem für Öffnungen oder Defekte in Organen

Implantierbares Verschlusssystem, mit dem Öffnungen in Organen oder Körperoberflächen einfach und schnell verschlossen werden können, in der Art, dass das Verschlusssystem aus einem membranbespannten Schirmchen besteht, wobei die Membran die zu verschliessende Öffnung abdichtet und eine Fixierstruktur das Verschlusssystem im Gewebe verankert.

VERSCHLUSSSYSTEM FÜR EIN OFFENES FORAMEN OVALE

STENT WITH LAMINATED THIN FILM GROUP

NEEDLE DEVICE AS WELL AS PROCEDURE FOR LOCKING A SEPTUM A DAMAGE

DEVICES FOR SEIZING AND ESTABLISHMENT OF SAILS WITH THE FLAP REPAIR

SYSTEM FOR THE IMPROVEMENT OF THE HEART FUNCTION

EQUIPMENT FOR THE OKKLUSION LINKING OF THE ATRIUM APPENDIX

Capturing and fixing leaflets in valve repair

Closure device for left atrial appendage

Join assembly for medical devices

A device (100) for occluding an aperture in a body of a patient includes a frame (110) that includes a plurality of elongate members (111) and a hub component (102) that includes a plurality of attachment members (150), wherein for each elongate member of the plurality of elongate members a first end of the elongate member is fixedly attached to an attachment member of the plurality of attachment members at an attachment region. The frame and the hub component together form at least one occlusive element. Each receptacle of the plurality of attachment members is configured to pivot with respect to the hub component, such that each attachment region is movable with respect to the hub component.

METHOD AND DEVICE FOR CAVITY OBLITERATION

NEEDLE APPARATUS AND METHODS FOR CLOSING SEPTAL DEFECTS

Apparatus and methods for closing a septal defect including a flap of tissue partially detached from a septum of a heart. A needle is advanced through a patient's vasculature within a delivery apparatus until the needle is disposed within a first chamber adjacent the septum. The needle is directed through the flap of tissue until the needle is disposed within a second chamber opposite the septum. A filament attached to an intermediate region of the needle is pulled, thereby causing the needle to pivot about the intermediate region such that the ends of the needle straddle the septal opening. A locking element is secured to the filament to secure the flap of tissue against the septum, and the filament is cut. Alternatively, the filament is biased to coil to engage the flap of tissue and secure the needle against the septum to close the opening.

METHODS AND APPARATUS FOR TREATMENT OF PATENT FORAMEN OVALE

Methods and apparatus for treatment of patent foramen ovale (PFO) generally include the use of a catheter (10) having a treatment device including one or more abrasive needles (12) at the distal end. In other embodiments, an energy transmission member or one or more apertures for dispensing a fluid may be used to contact and close the PFO.

CLIP-BASED SYSTEMS AND METHODS FOR TREATING SEPTAL DEFECTS

Systems and methods for treating internal tissue defects, such as septal defects, with clip-based devices are provided. An exemplary clip-based device includes a tubular body having at least a first and a second deflectable member coupled thereto. The first and second members are coupled on opposite ends of the tubular body and configured to deflect between an undeployed configuration and a deployed configuration. In the deployed configuration, each member extends outwardly away from the tubular body in a position configured to abut a tissue surface. The first and second members are preferably configured to maintain a tissue wall therebetween and at least partially close any opening in the tissue wall.

IMPLANTABLE MEDICAL DEVICE DEPLOYMENT SYSTEM

A medical device delivery system includes an implantable medical device and a delivery device. The implantable medical device includes at least one attachment feature having an elastomeric element. The delivery device includes a catheter and an elongate element. The catheter is arranged to contact the elastomeric element, and the elongate element is arranged to releasably couple with the elastomeric element.

SPACE FILLING DEVICES

A device frame includes a plurality of elongate frame members, first and second hub members substantially aligned along a longitudinal axis of the device frame, and a coupling element that couples the first hub member to the second hub member. The device frame includes a face section, a laterally facing skirt section, and an inverted section. First portions of the elongate members define the face section and extend radially from the first hub member. Second portions of the elongate members define the laterally facing skirt section and extend in a distal, axial, and helical direction along a first rotational direction from the face section. Third portions of the elongate members define the inverted section and extend in a generally proximal direction from a distal portion of the laterally facing skirt section to the second hub member along a rotational direction opposite the first rotational direction.

TISSUE REPAIR IMPLANT AND DELIVERY DEVICE AND METHOD

A device having a temporary frame configured to carry an implant, the temporary frame being selectably movable between a retracted position and a deployed position, the implant being in a relaxed state when carried by the frame in the retracted position, the implant being in a taut state when carried by the frame in the deployed position.

DEVICES AND METHODS FOR OCCLUDING ABNORMAL OPENINGS IN A PATIENT'S VASCULATURE

A medical device (100) is provided in which one or both ends of the device encourage the formation of tissue across substantially the entire area of the respective end that is exposed to the blood flow for reducing the risk of a thrombotic embolism. The medical device includes a tubular structure (130) having at least one expanded volume portion (180) and a tapered transition portion (190). The tubular structure may be made through the braiding of a number of strands, and a first end feature (140) may be used to secure the proximal strand ends. The proximal strand ends may be secured via the proximal end of the first end feature, such that the tapered transition portion is formed over the circumferential surface of the first end feature, and only a proximal end surface (or a portion of the proximal end surface) of the first end feature is exposed to the path of flowing blood.

OCCLUSIVE DEVICES WITH ANCHORS EXTENDING FROM PERIPHERAL EDGE OF THE OCCLUSIVE FACE

An occlusive device (100) includes a frame element (102) having a distal end (112) and a proximal end (110), and a delivery configuration and a deployed configuration. The occlusive device also includes an occlusive face (106) having a peripheral edge (114), where the occlusive face positioned toward the proximal end of the frame element. The occlusive device also includes at least one anchor (50) positioned at the peripheral edge of the occlusive face, where the at least one anchor extends at an acute angle to the peripheral edge of the occlusive face.

APICAL PUNCTURE ACCESS AND CLOSURE SYSTEM

A device, system, and method for providing access to, and sealing of, a body organ includes an implant device. An implant device has a main body having an internal access lumen, with a plurality of prongs extending from a distal end of the main body. The main body can include two lumens, one slidable within the other, to form a single continuous lumen with an adjustable length. The main body has an expanded configuration with an expanded diameter, and an unexpanded configuration with an unexpanded diameter. The prongs have a generally straight configuration where they extend distally of the distal end of the main body, and a bent configuration where the prongs bend around so that their tips extend proximally of the distal end of the main body. The device may include a hemostatic barrier to prevent fluid leakage therethrough when the main body is in the unexpanded configuration.

SINGLE DISC OCCLUSIONARY PATENT FORAMEN OVALE CLOSURE DEVICE

The present invention is a method and device for closing a passageway in a body, for example a patent foramen ovale (PFO) in a heart, and related met hods of using such closure devices for closing the passageway.

Devices and methods for occluding abnormal openings in a patient's vasculature

A medical device (100) is provided in which one or both ends of the device encourage the formation of tissue across substantially the entire area of the respective end that is exposed to the blood flow for reducing the risk of a thrombotic embolism. The medical device includes a tubular structure (130) having at least one expanded volume portion (180) and a tapered transition portion (190). The tubular structure may be made through the braiding of a number of strands, and a first end feature (140) may be used to secure the proximal strand ends. The proximal strand ends may be secured via the proximal end of the first end feature, such that the tapered transition portion is formed over the circumferential surface of the first end feature, and only a proximal end surface (or a portion of the proximal end surface) of the first end feature is exposed to the path of flowing blood.

의료 장치 고정 앵커

... 이식 가능한 의료 장치(100)는 적어도 하나의 세장형 부재(120)를 포함하는 프레임을 포함한다. 이식 가능한 의료 장치는 또한 제1 커프(210), 제2 커프(220), 이식 장소에서 조직에 고정함으로써 이식 가능한 의료 장치를 이식 장소에서 적소에 유지하도록 구성된 조직 맞물림 부재(230), 및 아치형 형상을 갖고 제1 커프의 제1 단부에 그리고 제2 커프의 제2 단부에 연결되는 커프 결합 부재(240)를 구비하는 고정 부재(200)를 포함한다. 제1 커프는 적어도 하나의 세장형 부재의 제1 부분의 주연부를 실질적으로 둘러싸며, 제2 커프는 적어도 하나의 세장형 부재의 제2 부분의 주연부를 실질적으로 둘러싸고, 커프 결합 부재는 적어도 하나의 세장형 부재의 임의의 부분의 주연부를 실질적으로 둘러싸지 않는다.

EXPANDABLE OCCLUSION DEVICES AND METHODS OF USE

Devices and methods for occluding the left atrial appendage are disclosed herein. An occlusion device can include an expandable lattice structure having a proximal portion configured to be positioned at or near the ostium of the LAA, a distal portion configured to extend into an interior portion of the LAA, and a contact portion between the proximal and distal portions. In several embodiments, the expandable lattice structure includes an occlusive braid configured to contact and seal with tissue of the LAA and a structural braid enveloped by the occlusive braid. The structural braid can be coupled to the occlusive braid at a proximal hub located at the proximal portion of the lattice structure. The structural braid is configured to drive the occlusive braid radially outward. The occlusive braid can have an atrial face at the proximal portion facing the left atrium LA, and the atrial face can have a low-profile contour that mitigates thrombus formation at the atrial face.

Energy based devices and methods for treatment of patent foramen ovale

Methods and apparatus for treatment of patent foramen ovale (PFO) provide for applying energy to tissues adjacent the PFO with a catheter device to substantially close the PFO acutely. Apparatus generally includes a catheter device having at least one energy transmission member at or near its distal end configured to apply energy to PFO tissues to acutely, substantially close the PFO. Applied energy may be monopolar or bipolar radiofrequency energy or any other suitable energy, such as laser, microwave, ultrasound, resistive heating or the like. Some embodiments of a catheter device fuirther include one or more tissue apposition members near the distal end for helping bring PFO tissues together, such as a PFO covering member, a vacuum applying member and/or the like. PFO closure via energy-based approaches of the invention may help prevent stroke, treat migraine headache, and possibly treat or prevent other medical conditions.

Expandable bioabsorbable plug apparatus and method

An apparatus for occluding a venous or arterial puncture site is disclosed including a plug insertable within, or adjacent to, a puncture site in a wall of a body lumen. An insert is forced into an aperture within the plug to cause expansion thereof. The insert may be drawn into the aperture by applying tension to a line passing therethrough and secured to the insert. Barbs may secure to the plug to engage the wall of the body lumen or adjacent tissue tract. Elongate members passing through the wall of the plug may be forced outwardly into the wall of the body lumen or adjacent tissue as the insert is forced into the aperture.

Needle Apparatus for Closing Septal Defects and Methods for Using Such Apparatus

Apparatus and methods for closing a septal defect including a flap of tissue partially detached from a septum of a heart. A needle is advanced through a patient's vasculature within a delivery apparatus until the needle is disposed within a first chamber adjacent the septum. The needle is directed through the flap of tissue until the needle is disposed within a second chamber opposite the septum. A filament attached to an intermediate region of the needle is pulled, thereby causing the needle to pivot about the intermediate region such that the ends of the needle straddle the septal opening. A locking element is secured to the filament to secure the flap of tissue against the septum, and the filament is cut. Alternatively, the filament is biased to coil to engage the flap of tissue and secure the needle against the septum to close the opening.

Apical puncture access and closure system

A device, system, and method for providing access to, and sealing of, a body organ includes an implant device. An implant device has a main body having an internal access lumen, with a plurality of prongs extending from a distal end of the main body. The main body can include two lumens, one slidable within the other, to form a single continuous lumen with an adjustable length. The main body has an expanded configuration with an expanded diameter, and an unexpanded configuration with an unexpanded diameter. The prongs have a generally straight configuration where they extend distally of the distal end of the main body, and a bent configuration where the prongs bend around so that their tips extend proximally of the distal end of the main body. The device may include a hemostatic barrier to prevent fluid leakage therethrough when the main body is in the unexpanded configuration.

Multilayered expandable braided devices and methods of use

Devices and methods for occluding blood flow into a body cavity are disclosed herein. An occlusion device can include an expandable lattice structure having an occlusive braid and a structural braid. In some embodiments, the structural braid is enveloped by the occlusive braid, and the occlusive braid is configured to contact and seal with tissue. The structural braid can have a first pick angle and the occlusive braid can have a second pick angle that is greater than the first pick angle. In some embodiments, the occlusion device is configured to occlude the left atrial appendage.

System and method for transapical access and closure

Embodiments are described for creating and closing tissue access ports, such as transapical access ports, which involve placement of an introducer across the subject tissue structure, and deployment of a controllable port closure device assembly configured to remain in place with a ratcheting mechanism, and to hold the tissue surrounding the previous access port location closed against a sealing disc with proximal and distal strut assemblies, after the introducer has been removed.

DEVICES AND METHODS FOR TREATING FISTULAE AND OTHER BODILY OPENINGS AND PASSAGEWAYS

Some aspects of the present invention are directed to unique products and methods for treating fistulae and other passageways and openings in the body. In some preferred forms, an inventive construct will include an elongate graft body that incorporates a plurality of sheet or sheet-like segments. The plurality of sheet or sheet-like segments, in some arrangements, will be stacked in a generally longitudinal direction along the length of the plug body, and optionally, the segments will be received over one or more elongate elements. Elongate elements of this sort can take a variety of forms including a suture, wire, filament, or other relatively thin-bodied elongate member, although in some forms, an elongate element will be or include a somewhat heftier structure such as a biodegradable or non-biodegradable three-dimensional body. 120-. (canceled)21. A medical implant , comprising:an elongate implant body including a plurality of sheet segments, each sheet segment of the plurality of sheet segments having a top surface, a bottom surface and at least one side edge, the plurality of sheet segments being stacked with the top surface of a first sheet segment facing the bottom surface of an adjacent sheet segment;wherein sheet segments of the plurality of sheet segments comprise a first material and a second material different from the first material.22. The medical implant of claim 21 , wherein:the first material comprises a naturally derived material and the second material comprises a non-naturally derived material.23. The medical implant of claim 22 , wherein:the naturally derived material comprises extracellular matrix (ECM) material.24. The medical implant of claim 23 , wherein:the non-naturally derived material comprises a biodegradable synthetic polymer.25. The medical implant of claim 24 , wherein:the plurality of sheet segments includes sheet segments comprising the extracellular matrix (ECM) material and other sheet segments comprising the biodegradable ...

PATENT FORAMEN OVALE (PFO) TUNNEL FILLER

A patent foramen ovale (PFO) tunnel filler medical device including device anchors coupled to and extending outwardly from a filler portion of a device frame that has a generally planar shape configured to fill a PFO tunnel, and a delivery system including the same are described herein. The medical device includes a fabric layer and the device anchors are configured to extend outwardly from the device frame. 1. A medical device for treating a patent foramen ovale (PFO) target site , the medical device comprising:a device frame having a generally planar shape configured to fill a PFO tunnel and formed from a shape memory material, wherein the device frame comprises a filler portion; andat least one fabric layer covering the filler portion of the device frame.2. The medical device of claim 1 , wherein the shape memory material is selected from nitinol and MP35.3. The medical device of claim 1 , wherein the shape memory material comprises a polymer.4. The medical device of claim 1 , wherein the fabric layer comprises at least one of metal fabric claim 1 , polymer fabric claim 1 , metal mesh claim 1 , polymer mesh claim 1 , braided wire claim 1 , woven wire claim 1 , braided polymer claim 1 , woven polymer claim 1 , nonwoven polymer claim 1 , and combinations thereof.5. The medical device of claim 1 , further comprising a plurality of device anchors extending outwardly from the filler portion and coupled to at least one of the device frame and the at least one fabric layer.6. The medical device of claim 5 , wherein each of the plurality of device anchors is one of a knurl claim 5 , a knot claim 5 , and a loop formed from the fabric layer.7. The medical device of claim 5 , further comprising at least one channel formed within the fabric layer claim 5 , and wherein each of the plurality of device anchors extends out of the at least one channel.8. The medical device of claim 5 , wherein the plurality of device anchors comprises a plurality of hooks.9. The medical device of ...

TISSUE AND VASCULAR CLOSURE DEVICES AND METHODS OF USE THEREOF

Devices and methods for closing access points in tissue are described. The devices include a tubular element fabricated form, for example, biologic material, a biologic tubular structure, or synthetic material. Using minimally invasive procedures, the devices and methods described herein allow implantation of the tubular element through the access point or wound such that it traverses the tissue. The tube has a sealed end which prevents leakage of fluid from, for example, the heart or a vessel upon securing the tube to the tissue. 1. A vascular closure device comprisinga sealing tube, wherein said sealing tube comprises a first end at the distal end of the sealing tube which is open and a second end at the proximal end of the sealing tube which is closed,a sheath which encases at least a portion of the sealing tube,a pusher cable positioned within the flexible tube, wherein the distal end of the pusher cable comprises one or more counters,wherein the pusher cable is moveably associated with the sealing tube, andwherein the sealing tube is moveably associated with the sheath, andwherein the outer surface of a distal portion of the sealing tube comprises an adhesive element.2. The closure device of claim 1 , wherein the sealing tube is comprised of pericardial tissue.3. The closure device of claim 1 , wherein the adhesive element is selected from one or more barbs or one or more suction cups.4. The closure device of claim 1 , wherein the second end is closed by a knot in the flexible tube.5. A method of closing a puncture in a blood vessel comprising use of the closure device of claim 1 , and comprising the steps:advancing the tubular closure device in a distal direction to the puncture wound until the distal end of the device is located past the puncture wound:pushing a pusher cable in a distal direction until the plurality of pusher arms radially expand away from the longitudinal axis of the sealing tube;pushing the nose cone in a distal direction to uncover the ...

FISTULA TREATMENT DEVICES AND METHODS

Disclosed herein are implantable fistula treatment devices and methods. In some embodiments, a distal anchor for an implantable fistula treatment device may comprise a suture and multiple foldable members including at least a distal-most foldable member and a proximal-most foldable member. The distal-most foldable member may comprise a suture attachment structure. The proximal-most foldable member may be configured to couple to a surface of a body lumen at a distal opening of a fistula. 1. A distal anchor for an implantable fistula treatment device , the distal anchor comprising:a suture;a distal-most member;a suture attachment structure attaching the suture to the distal-most member; andmultiple torus-shaped foldable members, including a proximal-most torus-shaped foldable member and at least one additional torus-shaped foldable member positioned between the distal-most member and the proximal-most foldable member, wherein the multiple foldable members are configured to slide along the suture toward the distal-most member, and wherein at least one of the multiple foldable members forms a seal with the distal-most member or another foldable member adjacent the distal-most foldable member,wherein the proximal-most foldable member is configured to couple to a surface of a body lumen at a distal opening of a fistula and occlude the fistula at the distal opening.2. The distal anchor of claim 1 , wherein each of the torus-shaped foldable members includes at least one locking feature configured to lock with a corresponding locking feature on an adjacent one of the torus-shaped foldable members.3. The distal anchor of claim 1 , further comprising a post for extending through central openings of the multiple torus-shaped foldable members.4. The distal anchor of claim 1 , wherein the distal-most member comprises a sphere.5. The distal anchor of claim 4 , further comprising an additional spheroidal member disposed between the distal-most member and a most-distal of the torus- ...

SYSTEM AND METHOD FOR TRANSAPICAL ACCESS AND CLOSURE

Embodiments are described for creating and closing tissue access ports, such as transapical access ports, which involve placement of an introducer across the subject tissue structure, and deployment of a controllable port closure device assembly configured to remain in place with a ratcheting mechanism, and to hold the tissue surrounding the previous access port location closed against a sealing disc with proximal and distal strut assemblies, after the introducer has been removed. 1a. a delivery member having proximal and distal ends;b. a first helical member having proximal and distal ends and a helical shape, the proximal end coupled to the delivery member distal end, the distal end extending distally of the delivery member distal end;c. an anchor member removably coupled to the helical member distal end; andd. a suture member coupled distally to a portion of the anchor member and extending proximally to a position wherein at least a portion of it may be freely manipulated by an operator;wherein upon rotation of the delivery member in a first direction, the first helical member and coupled anchor member are advanced across at least a portion of the wall of the tissue structure, pulling along the distal portion of the suture member in a deployed suture pattern which remains coupled to the anchor member, the deployed suture pattern being characterized in that it is substantially helical and represents a number of helical loops encapsulated by the wall of the tissue structure that is greater than about one and one-half helical loops, and is less than about four helical loops.. A system for providing surgical access across a wall of a tissue structure, comprising: This application is a continuation of U.S. patent application Ser. No. 13/725,903 filed on Dec. 21, 2012, which is a continuation of U.S. patent application Ser. No. 13/640,041 filed on Oct. 8, 2012 which is a U.S. National Stage filing under 35 U.S.C. §371 of International Application No. PCT/US2011/040085, ...

Spring barb for medical device

Disclosed herein is an anchor for use with a medical device. The anchor includes a coil, a barb, and a turn connecting the coil to the barb. The anchor may be made of a shape memory material. The coil may have a first handedness, and the turn may have a second handedness opposite the first handedness. The anchor may be attached to the medical device by a friction fit, in some cases without being attached by welding, soldering, adhesive, or crimping.

IMPLANT RETRIEVAL SYSTEM

Disclosed is an adjustable occlusion device for use in a body lumen such as the left atrial appendage. The occlusion device is removably carried by a deployment catheter. The device may be enlarged or reduced to facilitate optimal placement or removal. Methods are also disclosed. 1. A retrieval catheter for retrieving a device from an implantation site within the body, comprising: an elongate, flexible body, having a proximal end and a distal end; a grasping structure on the distal end, for grasping the device; a flared tubular sleeve, for surrounding at least a portion of the device; and an outer tubular sleeve, for surrounding the flared tubular sleeve. This application is a continuation of U.S. patent application Ser. No. 13/617,308, filed Sep. 14, 2012, which is a continuation of U.S. patent application Ser. No. 10/441,600, filed May 19, 2003, now U.S. Pat. No. 8,287,563, which is a divisional of U.S. patent application Ser. No. 10/033,371, filed Oct. 19, 2001, now U.S. Pat. No. 7,044,134, which is a continuation-in-part of U.S. patent application Ser. No. 09/435,562, filed Nov. 8, 1999, now U.S. Pat. No. 7,128,073, the disclosures of which are incorporated in their entirety herein by reference.Embolic stroke is the nation's third leading killer for adults, and is a major cause of disability. There are over 700,000 strokes per year in the United States alone. Of these, roughly 100,000 are hemoragic, and 600,000 are ischemic (either due to vessel narrowing or to embolism). The most common cause of embolie stroke emanating from the heart is thrombus formation due to atrial fibrillation. Approximately 80,000 strokes per year are attributable to atrial fibrillation. Atrial fibrillation is an arrhythmia of the heart that results in a rapid and chaotic heartbeat that produces lower cardiac output and irregular and turbulent blood flow in the vascular system. There are over five million people worldwide with atrial fibrillation, with about four hundred thousand new ...

Devices and methods for occlusion of an atrial appendage

Various aspects of the present disclosure are directed toward apparatuses, methods, and systems as relating to occlusion. In certain instances, the apparatuses, methods, and systems may include a device for placement in vessels, appendages, and openings in a body. The device may include a unitary frame having a face portion that includes a center frame portion a plurality of elongate members.

TISSUE ANCHORS HAVING BI-DIRECTIONAL ARRAYS OF BARBED PINS FOR JOINING TISSUE LAYERS

A tissue anchor includes a plate having a top surface and a bottom surface, and an array of first pins coupled with the plate, whereby each first pin includes an elongated shaft having a lower end with a first barb facing away from the bottom surface of the plate. The plate has an array of second pin apertures that are offset from the first pins, whereby each second pin aperture has a diameter that extends from the top surface to the bottom surface of the plate. The tissue anchor includes an array of second pins extending through the second pin apertures, whereby each second pin has an elongated shaft having an upper end including a second barb facing away from the top surface of the plate and a lower end including a stop that is located below the bottom surface of the plate. The elongated shafts of the second pins have outer diameters that are smaller than the diameters of the second pin apertures for allowing the elongated shafts of the second pins to slide within the second pin apertures. The second barbs and the stops of the second pins have outer diameters that are larger than the diameters of the second pin apertures. 1. A tissue anchor comprising:a plate having a top surface and a bottom surface;an array of first pins coupled with said plate, wherein each said first pin includes an elongated shaft having a lower end with a first barb facing away from said bottom surface of said plate;said plate having an array of second pin apertures that are offset from said first pins, wherein each said second pin aperture has a diameter, and wherein each said second pin aperture extends from said top surface to said bottom surface of said plate;an array of second pins extending through said second pin apertures, wherein each said second pin has an elongated shaft having an upper end including a second barb facing away from said top surface of said plate and a lower end including a stop that is located below said bottom surface of said plate, wherein said elongated shafts ...

DEVICES AND METHODS FOR OCCLUDING OR PROMOTING FLUID FLOW

Devices and methods for occluding or promoting fluid flow through openings are disclosed. In one exemplary embodiment an occlusion device is provided having an expandable outer elongate tubular body, a guide member extending from a distal end of the outer body, and a slide tube disposed within the outer body, the proximal portions of the outer body and the slide tube being fixedly mated. The slide tube is configured to slide distally within the outer tubular body when the tubular body is expanded to form wings. A tether can be included as part of the device and it can be used to assist in positioning and locking a location of the device in an opening. Exemplary methods for delivering devices disclosed herein are also provided. 1. A method for repairing a valve , the method comprising:advancing a first tubular assembly into a first opening within a first portion of a valve, the first tubular assembly having a first elongate tubular body and a first inner tube extending partially therethrough, the first elongate tubular body having distal and proximal portions;applying force to the first elongate tubular body to move the first elongate tubular body relative to the first inner tube to thereby cause the distal and proximal portions of the first elongate tubular body to expand and form respective distal and proximal wings;advancing a second tubular assembly into a second opening within a second portion of the valve, the second tubular assembly having a second elongate tubular body and a second inner tube extending partially therethrough, the second elongate tubular body having distal and proximal portions;applying force to the second elongate tubular body to move the second elongate tubular body relative to the second inner tube to thereby cause the distal and proximal portions of the second elongate tubular body to expand and form respective distal and proximal wings; andmoving the first and second tubular assemblies toward each other to bring the first and second ...

Uncoupled LAA Device

A medical device for treating an LAA is presented. The device includes a cap, a bulb and a joint assembly therebetween. The cap is a three layer mesh structure with a retaining hub securing the layers together. A plurality of proximal wire loops extend from the base layer to a proximal post of the joint assembly. The bulb has a plurality of distal wire loops that extend between a terminal post and a distal post of the joint assembly. The joint assembly comprises a first ball joint, a second ball joint and a housing. Each ball joint is retained in the housing independent ball and socket relationships. Each ball joint and post defines a longitudinal axis. The housing defines a housing longitudinal axis. By way of the ball and socket relationship each ball joint longitudinal axis may form an angle of between about 0 to about 35 degrees with the housing longitudinal axis in any direction. 1. A medical device to treat the LAA , the medical device having a deployed state and a confined state , the medical device comprising:a cap, a bulb and a joint assembly therebetween;the cap having a plurality of layers, one of the layers defining a base layer, the base layer constructed of at least two sections of mesh material immediately adjacent to one another, a plurality of proximal wire loops extending from the cap to a proximal post of the joint assembly;the bulb having a plurality of distal wire loops that extend between a terminal post and a distal post of the joint assembly, adjacent distal wire loops being connected one to another by at least one connection collar;the joint assembly comprising a first ball joint, a second ball joint and a housing, the proximal post extending proximally from the first ball joint, the distal post extending distally from the second ball joint, the housing having a proximal collar and a distal collar, the proximal collar retaining the first ball joint in a first ball and socket relationship, the distal collar retaining the second ball joint in ...

AN OCCLISIVE MEDICAL IMPLANT

An occlusive medical implant having a frame actuatable between a collapsed delivery configuration and an expanded implanted configuration, the frame including a generally tubular portion with a threaded insert configured to removably attach to a threaded distal end of a core wire; an occlusive element disposed on the frame; where a proximal portion of the occlusive element and the proximalmost extent of the threaded insert are substantially coplanar with a plane defined by three or more proximalmost extents of the frame in the expanded implanted configuration. 1. (canceled)2. A medical implant , comprising:a frame configured to actuate between a collapsed configuration and an expanded configuration,wherein the expanded configuration of the frame is compliant and is configured to substantially conform to a shape and/or geometry of a lateral wall of a left atrial appendage; and to be in sealing engagement therewith when implanted in the left atrial appendage;an occlusive element configured to cover at least a proximal portion of the frame, which proximal portion spans an opening formed by the lateral wall of the left atrial appendage in the expanded configuration of the frame, and is configured to cover at least a portion of the lateral wall of the left atrial appendage distal of the opening;wherein a proximal end of the frame includes a generally tubular portion, the generally tubular portion being configured to attach to a distal end of a core wire;wherein the generally tubular portion of the frame includes a threaded insert coupled thereto,wherein a proximalmost extent of the threaded insert is substantially coplanar with a plane defined by three or more proximalmost extents of the frame in the expanded configuration,wherein the portion of the occlusive element covering the opening is substantially coplanar with the proximalmost extent of the threaded insert and the plane defined by the proximalmost extent of the frame in the expanded configuration.3. The medical ...

SEALING DEVICE AND DELIVERY SYSTEM

A medical device for sealing a defect in a body includes a wire frame that includes a plurality of wires that form a first occluding member and a second occluding member. In some embodiments, a sealing member is in contact with the wire frame. In some embodiments, the sealing member is configured to define one or more openings in the sealing member. 1. A medical device comprising: a first eyelet,', 'a second eyelet,', 'a first disc member,', 'a second disc member, and', 'a defect-occupying portion disposed between the first disc member and the second disc member; and, 'a plurality of wound wires forminga sealing member in contact with the frame including one or more openings configured to at least partially prevent or relieve a fluid pressure differential between an interior and an exterior of the sealing member, the sealing member forming a first occluding member with the first disc member and a second occluding member with the second disc member configured to seal a range of defect sizes from a largest defect size to a smallest defect size that is approximately 60% of the largest defect size.2. The medical device of claim 1 , wherein the one or more openings define passages through the sealing member.3. The medical device of claim 1 , wherein the one or more openings being configured to at least partially prevent or relieve the fluid pressure differential facilitates maintaining the medical device in a desired position and configuration in relation to the patient's anatomy.4. The medical device of claim 1 , wherein the one or more openings includes two claim 1 , three claim 1 , four claim 1 , five claim 1 , six claim 1 , seven claim 1 , eight claim 1 , nine claim 1 , ten claim 1 , eleven claim 1 , or twelve openings.5. The medical device of claim 1 , wherein the one or more openings are arranged on at least one of the first occluding member and the second occluding member.7. The medical device of claim 1 , wherein the range of defect sizes includes at least one of ...

Fixation devices, systems and methods for engaging tissue

System for fixation of leaflets of a heart valve including a delivery catheter having an elongated shaft, a proximal end portion and a distal end portion configured to be positioned proximate native leaflets of a heart valve from a remote vascular access point, the delivery catheter further includes a rotatable actuator rod having a threaded fastener at a distal end thereof, and a fixation device releasably coupled by a threaded connection to the threaded fastener of the actuator rod. The fixation device includes a first arm moveable between a closed position and an open position, a second arm moveable between a closed position and an open position. The fixation device further includes a first gripping element movable relative to the first arm in the open position, the first gripping element biased toward the first arm to capture a first leaflet of the heart valve therebetween, and a second gripping element movable relative to the second arm in the open position, the second gripping element biased toward the second arm to capture a second leaflet of the heart valve therebetween. The first gripping element and the second gripping element each includes a plurality of barbs extending therefrom, the plurality of barbs of each of the first gripping element and the second gripping element being aligned transversely in at least one row. The fixation device further includes a covering disposed on each of the first gripping element and the second gripping element, wherein the plurality of barbs of the first gripping element and the second gripping element, respectively, protrude through the covering.

CLOSING DEVICE FOR TISSUE OPENINGS

There are shown and described embodiments of closure devices and systems for closing holes in tissue such as those caused unintentionally (e.g. hernia) or intentionally (e.g. openings in the right atrial appendage to access cardiac tissue). Such devices and systems include one or more mesh elements or anchors. In particular embodiments, a closure device includes first and second mesh closure members and a tether or stem connecting them. Embodiments of a delivery device for such closure devices are also described. 1. A closure for an opening in tissue , comprising:a first closure element, the first closure element having a first mesh enclosure, the first mesh enclosure having a first distal narrowed end and a second proximal narrowed end and a central volume, each of the first and second ends being inverted so as to be within the central volume of the first mesh enclosure, each of the first and second ends being surrounded by respective external surfaces of the first mesh enclosure;a second closure element, the second closure element having a second mesh enclosure physically separate from the first mesh enclosure, the second mesh enclosure having a third distal narrowed end and a fourth proximal narrowed end and a central volume, the third end being inverted so as to be within the central volume of the second mesh enclosure, each of the third and fourth ends being surrounded by respective external surfaces of the second mesh enclosure;a tether joining the first and second closure elements in an initial configuration prior to delivery of the closure elements to the opening, the tether having first and second enlarged ends, wherein the tether extends through at least the first narrowed end, parallel to and alongside the second narrowed end and into the second closure element, so that the first enlarged end of the tether is outside the first closure element adjacent or engaging the first end and the second enlarged end of the tether is within the central volume of the ...

Leadless pacemaker with collapsible anchoring device

The present disclosure provides improved leadless pacemakers. In one embodiment, the leadless pacemaker includes an implantable pulse generator releasably coupled to a collapsible anchoring device. The collapsible anchoring device includes at least one pacing electrode configured to contact tissue at a target site.

IMPLANTABLE SEALING DEVICE

An implantable sealing device is disclosed herein and includes an elongated elastic member having distal and a proximal ends, at least one sealing element including braiding having outside and inside faces. The braiding can include of a plurality of fine threads of a memory metal alloy and wherein at least one face of the braiding is coated by a membrane. The braiding can also include a fixing member positioned at one of the distal and proximal ends of the elastic member and being positioned opposite to the braiding. 1. A method for sealing a tissue opening , especially a trocar tube opening in a myocardium at an apex of a left ventricle comprising the steps of: an elongated elastic member having a distal and a proximal end;', 'at least one sealing element comprising a braiding extending radially from the elongated elastic member having outside and inside faces, the braiding being positioned respectively at one of the distal and proximal ends of the elastic member, wherein the braiding includes a plurality of fine threads of a memory metal alloy and wherein at least one face of the braiding is coated by a membrane; and', 'a fixing member being positioned respectively at the distal and proximal ends of the elastic member and being positioned opposite to the braiding;, "inserting a trocar tube including a folded sealing device and guiding the trocar tube through an opening in a myocardium into a patient's left ventricle, the sealing device comprising:"}pushing the braiding out of the trocar tube so that the umbrella moves from a folded position into a deployed position whereas the fixing member remains inside the trocar tube;stretching the elastic member by means of a tensioning cord and pulling the pre-stretched elastic member out of the opening in a myocardium whereby the fixing member is placed against a tissue of a myocardium and moves from a folded position into a deployed position;removing the trocar tube whereby the elastic member remains stretched; andremoving ...

Device, Kit And Method For Closure Of A Body Lumen Puncture

A medical device and method for closure of a puncture in a body lumen are disclosed. The device has an aggregate () of a support structure () and a substantially fluid tight patch member () attached thereto at an attachment unit (). The aggregate has a first, temporary delivery shape, for delivery to an interior of said body lumen and to be subsequently subjected to a change of shape to a second shape, which is a tubular shape. When delivered in said body lumen, the patch member is arranged radially outside of said tubular support structure and arranged towards an inner tissue wall of the body lumen. The aggregate is the detached from a delivery device and said puncture is intraluminally closed in a leakage tight manner, advantageously supported by a physiological pressure of a body fluid in said body lumen. The device may biodegrade over time. 1an elongate delivery unit having a distal end; and an aggregate ofa support structure having a first shape, which is a temporary delivery shape, for delivery to an interior of said body lumen through said puncture and to be subsequently controllably subjected to a change of shape to a second shape, which is a tubular shape, when delivered in said body lumen, anda patch member attached to said support structure at an intermediate portion between two opposite ends thereof; whereinsaid distal end of said elongate delivery unit is radially releasably attached to said aggregate at an attachment position intermediate between ends of said patch member and detachable therefrom upon deployment of said aggregate in said body lumen;wherein said patch member is sized and shaped for arranging it towards an inner tissue wall of said body lumen at a site of said puncture of said body lumen and extending over a puncture opening, andwherein said delivery unit extends in a direction radially from said aggregate through said opening, such that said puncture is controllably sealed off by said patch when drawing said delivery device in a ...

SYSTEM FOR LEFT ATRIAL APPENDAGE OCCLUSION

Disclosed is an occlusion device for use in a body lumen such as the left atrial appendage. The occlusion device includes an occlusion member and may also include a stabilizing member. The stabilizing member inhibits compression of the left atrial appendage, facilitating tissue in-growth onto the occlusion member. Methods are also disclosed. 1. (canceled)2. A device configured for implantation in a left atrial appendage , the device comprising:a support structure having a radially compressed configuration and a radially expanded configuration, wherein the support structure tapers radially inward from a proximal end of the support structure to a distal end of the support structure;a membrane extending along at least part of a proximal portion of the support structure; andone or more distal anchoring segments configured to engage a wall of the left atrial appendage extend radially outward from the distal end of the support structure,wherein the one or more distal anchoring segments are provided with an atraumatic configuration.3. The device of claim 2 , wherein the one or more distal anchoring segments extend radially outward in a proximal direction in the radially expanded configuration.4. The device of claim 2 , comprising three anchoring segments provided with an atraumatic configuration.5. The device of claim 2 , comprising 20 distal anchoring segments provided with an atraumatic configuration.6. The device of claim 2 , wherein the support structure comprises a plurality of spokes joined to an axial hub.7. The device of claim 6 , wherein each spoke of the plurality of spokes is forms cellular structures with one or more adjacent spokes to support the membrane.8. The device of claim 2 , wherein a release element of a delivery device is provided with a releasable lock for attachment to the proximal end of the support structure.9. The device of claim 8 , wherein the release element of a delivery device is adapted to be releaseably detached from the support structure ...

Method for left atrial appendage occlusion

Disclosed is an occlusion device for use in a body lumen such as the left atrial appendage. The occlusion device includes an occlusion member and may also include a stabilizing member. The stabilizing member inhibits compression of the left atrial appendage, facilitating tissue in-growth onto the occlusion member. Methods are also disclosed.

APICAL IMPLANTATION MITRAL VALVE BALLOON CLOSURE PLATE BLOCKING BODY AND IMPLANTATION METHOD

An apical implantation mitral valve balloon closure plate blocking body and an implantation method, for human heart repair are disclosed. A balloon closure plate made from an elastic plastic material which may be filled with a gas or a curable liquid is implanted via a small incision on the left side of the chest, enters the left ventricle via the apex, and is placed and fixed at a backflow hole position of a front and rear leaflet closure point of the mitral valve. The present disclosure treats diseases such as functional mitral valve regurgitation, and the success rate for repairing functional mitral valve backflow is more than 90%. 19-. (canceled)10: A transapical implantation mitral valve balloon closure plate blocking body comprising a closure plate , a guide wire , a guide ring and a fixing plug , wherein:the fixing plug is adapted to be fixed at an apex of a heart;an inside of the balloon closure plate is a balloon and is adapted to be located at a closure position of the anterior and posterior leaflets;a hook is adapted to be fixed in each of the right and left mitral annulus at the left and right leaflet joints of the heart;left and right guide wires are respectively passed through the same side hook and fixedly connected with an upper portion of the same side of the balloon closure plate;the guide ring is fixedly connected to the left lower portion and the right lower portion of an air bag closing plate, and the left and right guide wires pass through the same side of the guide ring respectively and fixedly connected to a fixing plug;an infusion tube connects to a lower bottom edge of the balloon closure plate and is extended to the body via a fixed plug; whereininfusion tube connects with the inside of the balloon closure plate; anda check valve is provided on the infusion tube whereupon a gas and curable liquid can fill in the balloon plate via the infusion tube.11: The transapical implantation mitral valve balloon closure plate blockage body of claim 10 ...

Fistula treatment devices and methods

Disclosed herein are implantable fistula treatment devices and methods. In some embodiments, a distal anchor for an implantable fistula treatment device may comprise a suture and multiple foldable members including at least a distal-most foldable member and a proximal-most foldable member. The distal-most foldable member may comprise a suture attachment structure. The proximal-most foldable member may be configured to couple to a surface of a body lumen at a distal opening of a fistula.

Multifunctional left atrial appendage (laa) occluder

Devices and methods for occluding the left atrial appendage (LAA) with a device having multifunctional capability. The device is delivered via transcatheter delivery into the LAA and anchored using a compliant frame and scaffold, which may be foam. The device further includes one or more electronic systems to provide a multitude of features related to sensing, electrical stimulation, pacing, communication, etc. The device may have an open configuration where an opening in the proximal end of the device allows for delivery of one or more sensors into and/or through the device. The device may be manipulated into a closed configuration to secure the electronic systems therein and close off the proximal end to provide the occlusive effects. The electronic systems therein may then be used for the various electronic and other functions.

LEFT ATRIAL APPENDAGE CLOSURE AND DELIVERY SYSTEM THEREOF

A left atrial appendage (LAA) closure () and a system () for delivering the LAA closure are disclosed. The LAA closure () includes supporting struts (), wherein the supporting struts () are distributed peripherally around a first hub () and extend outward, the supporting strut () bifurcates at a first position () into a left branch () and a right branch (). The left branch () of each supporting strut () and the right branch () of an adjacent supporting strut join each other at a second position () and extend distally to form a distal end. The LAA closure further includes a supporting rod () between adjacent supporting struts () which ensures stability, absence of irregular deformation and lateral slippage, of the LAA closure (). With the supporting rods () between the adjacent supporting struts (), the LAA closure () forms a dense mesh which imparts high overall strength of the LAA closure (). 1. A left atrial appendage (LAA) closure , comprising a plurality of supporting struts distributed peripherally around a first hub and extending outwardly from the first hub , the supporting strut bifurcating at a first position into a left branch and a right branch , the left branch of a supporting strut and the right branch of an adjacent supporting strut joining each other at a second position and extending distally to form a distal end , the LAA closure further comprising a supporting rod disposed between adjacent supporting struts.2. The LAA closure according to claim 1 , wherein the supporting rod has a first end connected to the outside of the first hub claim 1 , extending outwardly and bifurcating into a second end and a third end at a third position.3. The LAA closure according to claim 2 , wherein the second end is fixed between the first and second positions of the left branch of the supporting struts claim 2 , and the third end is fixed between the first and second positions of the right branch of the supporting struts.4. The LAA closure according to claim 2 , ...

IMPLANT FOR CLOSING AN OPENING IN TISSUE

An implant for closing an opening in tissue such as a fistula or a sinus comprises a coil having a substantially uniform outer diameter. The coil forms an internal passage having a diameter that tapers from a distal end to a proximal end. The implant may be delivered using a non-tapered driver coil 186-. (canceled)87. An implant for closing an opening in tissue , the implant comprising:a coil having a proximal driver end and a distal tissue insertion end;an outer diameter of the coil being substantially uniform along a length between the distal tissue insertion end and the proximal driver end; andan inner diameter of the coil tapering from the distal tissue insertion end toward the proximal driver end.88. The implant of claim 87 , wherein the inner diameter of the coil at the distal tissue insertion end is from 1 mm to 6 mm.89. The implant of claim 87 , wherein the inner diameter of the coil at the proximal driver end is from 0.5 mm to 2 mm.90. The implant of claim 87 , wherein a pitch of the coil is from 2 mm to 4 mm.91. The implant of claim 87 , wherein the distal tissue insertion end of the coil comprises a feathered edge.92. The implant of claim 87 , wherein the coil comprises an outer rail.93. The implant of claim 92 , wherein the outer rail comprises a plurality of rail segments which are spaced-apart along the coil.94. The implant of claim 93 , wherein the plurality of rail segments comprise a plurality of first segments and a plurality of second segments which are offset from the plurality of first segments.95. The implant of claim 94 , wherein at least some of the rail segments of the plurality of rail segments comprise an anti-rewind feature.96. A delivery device for delivery of an implant into tissue claim 94 , the delivery device comprising:a delivery tube having a proximal end and a distal end, wherein the distal end of the delivery tube includes an implant engagement feature configured for engagement with a proximal end of an implant; anda delivery ...

SYSTEM AND METHOD FOR TRANSAPICAL ACCESS AND CLOSURE

Embodiments are described for creating and closing tissue access ports, such as transapical access ports, which involve placement of an introducer across the subject tissue structure, and deployment of a controllable port closure device assembly configured to remain in place with a ratcheting mechanism, and to hold the tissue surrounding the previous access port location closed against a sealing disc with proximal and distal strut assemblies, after the introducer has been removed. 1a. a delivery member having proximal and distal ends;b. a first helical member having proximal and distal ends and a helical shape, the proximal end coupled to the delivery member distal end, the distal end extending distally from the delivery member distal end;c. an anchor member removably coupled to the helical member distal end;d. a suture member coupled distally to a portion of the anchor member and extending proximally to a position wherein at least a portion of it may be freely manipulated by an operator; ande. an elongate instrument at least partially inserted through the first helical member;wherein upon rotation of the delivery member in a first direction, the first helical member and coupled anchor member are advanced across at least a portion of the wall of the tissue structure, pulling along the distal portion of the suture member in a deployed suture pattern which remains coupled to the anchor member, the deployed suture pattern being characterized in that it represents a number of helical loops encapsulated by the wall of the tissue structure that is greater than about one and one-half helical loops, and is deployed in a substantially helical configuration selected to movably accommodate the elongate instrument therethrough.. A system for providing surgical access across a wall of a tissue structure, comprising: This application is a continuation of U.S. patent application Ser. No. 14/558,584 filed on Dec. 2, 2014, which is a continuation of U.S. patent application Ser. No. ...

Expandable occlusion devices and methods of use

An occlusion device and method for occluding an undesirable vascular structure, such as a septal defect or left atrial appendage. The occlusion device includes a lattice structure that expands from a contracted catheter-deliverable state to an expanded state that occludes the vascular structure. The lattice structure has one or more braided layers, with structural braided layers that provide structural support to the device, and occlusive layers that provide a lattice braiding or pore sizes that promote further occlusion by a biological process, such as tissue ingrowth that further occludes the affected vascular structure.

Self-locking suture strand

A novel suture strand is herein disclosed. The suture strand includes a suture body, a hole, and multiple barbs. The hole is formed transversely through a first portion of the suture body. The barbs are coupled to a second portion of the suture body and are designed to allow the second portion of the suture body to pass through the hole in a first direction and prevent movement of the second portion of the suture body in an opposite, second direction.

SEALING DEVICE AND DELIVERY SYSTEM

A medical device for sealing a defect in a body includes a wire frame that includes a plurality of wires that form a first occluding member and a second occluding member. In some embodiments, a sealing member is in contact with the wire frame. In some embodiments, the sealing member is configured to define one or more openings in the sealing member. 1. (canceled)2. A medical device comprising:a plurality of wound wires forming:a first eyelet,a second eyelet,a first disc member,a second disc member; anda sealing member in contact with the frame configured to at least partially prevent or relieve a fluid pressure differential between an interior and an exterior of the sealing member, wherein each wire of the plurality of wires and a portion of the sealing member form a respective petal of the first disc member and each wire of the plurality of wires and a portion of the sealing member form a respective petal of the second disc member.3. The medical device of claim 2 , wherein the first disc member is configured to conform to a geometry of a first tissue surface and to provide an apposition force against the first tissue surface and the second sic member is configured to conform to a geometry of a second tissue surface and to provide an apposition force against the second tissue surface.4. The medical device of claim 3 , wherein the sealing member is configured to at least partially prevent or relieve fluid pressure to facilitate a position of the first disc member relative to the first tissue surface and a position of the second disc member relative to the second tissue surface.5. The medical device of claim 2 , wherein open areas of the first eyelet and the second eyelet are configured to at least partially prevent or relieve fluid pressure between the interior and exterior of the sealing member to reduce expansion of the sealing member due to a differential pressure between the interior and exterior of the sealing member.6. The medical device of claim 2 , wherein ...

CLOSING OPENINGS IN ANATOMICAL TISSUE

A device for closing at least one opening leading to an anatomical cavity is delivered via a catheter positioned in a first opening leading to the anatomical cavity. An orientation control unit is positioned within the anatomical cavity. The orientation control unit defines an orientation of a portion of a tissue surface within the anatomical cavity that is skewed with respect to the first opening and orients a closure member of the device with the tissue surface. An occluding member and a constricting unit of the device are positioned within the anatomical cavity with the occluding member blocking a portion of an opening that is constricted by the constricting unit. An intermediate member of the device is positioned within the anatomical cavity and a closure unit employing at least one piercing element pierces through the intermediate member into a tissue wall surrounding the anatomical cavity. 1. (canceled)2. A medical system configured to close one or more openings , each of the one or more openings leading to an anatomical cavity , at least a portion of the medical system sized in at least one configuration to be deliverable through a first opening of the one or more openings into the anatomical cavity , and the at least the portion of the medical system comprising:an elongated member, a portion of the elongated member sized to be deliverable through the first opening into the anatomical cavity;a closure unit releasably coupled to the elongated member and arranged to be delivered into the anatomical cavity to a location at least proximate an interior tissue surface within the anatomical cavity, the closure unit further arranged to close an opening of the one or more openings located on the interior tissue surface within the anatomical cavity; andan intermediate member releasably coupled to the elongated member and arranged to be delivered into the anatomical cavity to a location between at least part of the closure unit and the interior tissue surface within the ...

Devices and methods for occluding abnormal openings in a patient's vasculature

A medical device is provided in which one or both ends of the device encourage the formation of tissue across substantially the entire area of the respective end that is exposed to the blood flow for reducing the risk of a thrombotic embolism. The medical device includes a tubular structure having at least one expanded volume portion and a tapered transition portion. The tubular structure may be made through the braiding of a number of strands, and a first end feature may be used to secure the proximal strand ends. The proximal strand ends may be secured via the proximal end of the first end feature, such that the tapered transition portion is formed over the circumferential surface of the first end feature, and only a proximal end surface (or a portion of the proximal end surface) of the first end feature is exposed to the path of flowing blood.

Closure device and methods for making and using them

A method that includes locating an opening in tissue by advancing a member through the opening in tissue and following locating the opening, deploying a medical device to aid with sealing the opening. The medical device includes a plurality of strut members forming a plurality of generally diamond-shaped openings, the plurality of strut member being configured to form an annular shaped structure with the generally diamond-shaped openings extending generally longitudinally relative to a longitudinal axis of the medical device. The medical device further includes a plurality of tissue engaging portions associated with the plurality of struts, each tissue engaging portion being disposed between adjacently positioned generally diamond-shaped openings.

NEEDLE APPARATUS FOR CLOSING SEPTAL DEFECTS AND METHODS FOR USING SUCH APPARATUS

Apparatus and methods for closing a septal defect including a flap of tissue partially detached from a septum of a heart. A needle is advanced through a patient's vasculature within a delivery apparatus until the needle is disposed within a first chamber adjacent the septum. The needle is directed through the flap of tissue until the needle is disposed within a second chamber opposite the septum. A filament attached to an intermediate region of the needle is pulled, thereby causing the needle to pivot about the intermediate region such that the ends of the needle straddle the septal opening. A locking element is secured to the filament to secure the flap of tissue against the septum, and the filament is cut. Alternatively, the filament is biased to coil to engage the flap of tissue and secure the needle against the septum to close the opening. 1delivering a closure apparatus to the septal defect, wherein the closure apparatus comprises (a) an elongate needle having a first end defining a tissue-penetrating tip, a second end defining a substantially blunt tip, and a filament extending from an intermediate portion of the needle between the first and second ends; and (b) a locking element securable to the filament, thereby preventing the locking element from moving along the filament away from the needle.. A method for closing a septal defect, comprising: This application is a continuation of U.S. patent application Ser. No. 13/679,945, filed Nov. 16, 2012, which is a continuation of U.S. patent spplication Ser. No. 13/281,235, filed Oct. 25, 2011, which is a continuation of U.S. patent application Ser. No. 10/734,670, filed on Dec. 11, 2003, now U.S. Pat. No. 8,070,826, which is a divisional of U.S. patent application Ser. No. 09/948,453, now U.S. Pat. No. 6,702,835, each of which are fully incorporated herein by reference.The present invention relates generally to apparatus and methods for treating septal defects, and more particularly to apparatus and methods for ...

Method and device for percutaneous left ventricular reconstruction

A method for reducing left ventricular volume, which comprises identifying infracted tissue during open chest surgery; reducing left ventricle volume while preserving the ventricular apex; and realigning the ventricular apex, such that the realigning step comprises closing the lower or apical portion of said ventricle to achieve appropriate functional contractile geometry of said ventricle in a dyskinetic ventricle of a heart.

Fascia Closure Tool

A laparoscopic tool used for closing fascia implements a folding mechanism, similar to single-fold or double-fold umbrellas, in combination with anchors and a graft membrane. The graft membrane is connected across a number of graft supports. The graft supports are radially oriented around a shaft. A trigger-actuated runner slides along the shaft; movement of the trigger-actuated runner causes the graft supports to unfold or fold, thanks to a plurality of stretchers. The graft supports include a first arm, a second arm, and a third arm which are connected to each other by hinges, allowing them to fold and unfold. An anchor is positioned at the end of the third arm, the anchor being able to securely lode into fascia. A grip and a trigger at a handle end of the shaft allow the double-double fold mechanism to be engaged and the anchors and graft membrane to be secured to fascia.

Occlusive devices

An occlusive device includes a frame element having a distal end and a proximal end, and a delivery configuration and a deployed configuration. The occlusive device also includes an occlusive face having a peripheral edge, where the occlusive face positioned toward the proximal end of the frame element. The occlusive device also includes at least one anchor positioned at the peripheral edge of the occlusive face, where the at least one anchor extends at an acute angle to the peripheral edge of the occlusive face.

Left atrial appendage closure and delivery system thereof

A left atrial appendage (LAA) closure (1) and a system (6) for delivering the LAA closure are disclosed. The LAA closure (1) includes supporting struts (11), wherein the supporting struts (11) are distributed peripherally around a first hub (10) and extend outward, the supporting strut (11) bifurcates at a first position (110) into a left branch (111) and a right branch (112). The left branch (111) of each supporting strut (11) and the right branch (112) of an adjacent supporting strut join each other at a second position (113) and extend distally to form a distal end. The LAA closure further includes a supporting rod (12) between adjacent supporting struts (11) which ensures stability, absence of irregular deformation and lateral slippage, of the LAA closure (1). With the supporting rods (12) between the adjacent supporting struts (11), the LAA closure (1) forms a dense mesh which imparts high overall strength of the LAA closure (1).

MEDICAL DEVICE FOR MODIFICATION OF LEFT ATRIAL APPENDAGE AND RELATED SYSTEMS AND METHODS

A medical device, system and method for modifying a left atrial appendage (“LAA”). The medical device system includes a tether anchored within the LAA and one or more tissue growth members or occluders configured to be slid over the tether and lodged within the LAA. With this arrangement, a physician may close-off the LAA with a selective number of tissue growth members to meet the varying LAA sizes as determined from imaging information while conducting the procedure. 1. A method for modifying a left atrial appendage , comprising:positioning a catheter adjacent the left atrial appendage;pushing a medical device having tines through a lumen of the catheter;anchoring the medical device within the left atrial appendage;deploying a tissue growth member of the medical device from the catheter, the medical device rotatably coupled to a threaded pusher member; andmaintaining the at least one tissue growth member in the left atrial appendage with a locking element, the locking element including multiple fingers that collapse directly dependent upon proximally moving the threaded pusher member relative to the tissue growth member.2. The method according to claim 1 , wherein anchoring the medical device further comprises anchoring the medical device with a tether coupled thereto.3. The method according to claim 1 , wherein the deploying the tissue growth member comprises pushing the tissue growth member over a tether coupled to the medical device.4. The method according to claim 3 , wherein pushing the tissue growth member over the tether further comprises positioning the catheter within the left atrial appendage and deploying the tissue growth member from the catheter while slidably coupled with the tether.5. The method according to claim 1 , wherein the deploying the tissue growth member further comprises deploying the tissue growth member having self-expanding frame members coupled to a polymeric element.6. The method according to claim 2 , further comprising disengaging ...

Adaptive Devices and Methods for Endoscopic Wound Closures

This invention is directed to devices and methods for improving wound closures produced during endoscopic surgery. These methods are directed to delivering and applying a quantity of hemostatic agents in either powder, solid, liquid, or gel form onto an open wound produced e.g., by polyp removal, followed by the application of pressure. The method is implemented preferably using existing endoscopic equipment; however, modifications to existing endoscopic insertion tubes, application and tamping devices and endoscopic clips deployed from the distal end of the insertion tube during endoscopic surgery are also within the scope of this invention. 1. A device for arresting blood flow from a wound within the alimentary canal of a living organism accessible only from a natural body orifice by endoscopic surgery , comprising:an endoscopic instrument inserting into the living organism through the natural body orifice;a retaining device traversing said endoscopic instrument for positioning in close proximity to, or in contact with the wound;a hemostatic substance traversing and exiting said endoscopic instrument into close proximity to the wound;said retaining device retaining said hemostatic substance adjacent to the wound for a time period sufficient to achieve hemostasis; andsaid hemostatic substance being a resin/ferrate or hydrogen resin in powder or tablet form.2. A device for arresting blood flow from a wound within the alimentary canal of a living organism as set forth in claim 1 , said retaining device comprising:an expandable bowl traversing said endoscopic instrument and expanding upon exiting said endoscopic instrument for positioning in close proximity to, or in contact with the wound;said expandable bowl retaining said hemostatic substance adjacent to the wound for a time period sufficient to achieve hemostasis and to form a scab over the wound.3. A device for arresting blood flow as set forth in claim 2 , further including:a plurality of barbed ends coupled to ...

Devices, systems and methods for engaging tissue

The present disclosure describes a system and method for securing medical devices to the tissue of a patient using one or more anchors. Anchors can be independent from or integral to the medical device deployed within the patient. Such anchors are configured to engage and maintain contact with the tissue using a tissue-penetrating point and bendable shaft.

OCCLUDER LOCKING MECHANISMS

A medical device including a locking mechanism and a method including activating the locking mechanism are described herein. The medical device includes distal and proximal disc portions and a locking mechanism. The locking mechanism is configured to pull and maintain the distal and proximal disc portions toward each other when the medical device is deployed in an expanded configuration. 1. A medical device for treating a target site , the medical device comprising:a tubular member comprising a proximal disc portion at a proximal end, a distal disc portion at a distal end, and a waist member extending between the proximal disc portion and the distal disc portion, wherein the tubular member has an expanded configuration when deployed at the target site and a reduced configuration for delivery to the target site; anda locking mechanism comprising a distal locking portion attached to the distal disc portion and a proximal locking portion attached to the proximal disc portion, wherein the distal locking portion and the proximal locking portion are configured to be coupled together when the medical device is in the expanded configuration.2. The medical device of claim 1 , wherein the locking mechanism is an active locking mechanism that requires manually coupling the distal locking portion to the proximal locking portion when in the expanded configuration.3. The medical device of claim 1 , wherein the locking mechanism is a passive locking mechanism that automatically couples the distal locking portion and the proximal locking portion when in the expanded configuration.4. The medical device of claim 1 , wherein the distal locking portion is located in a center of the distal disc portion and wherein the proximal locking portion is located in a center of the proximal disc portion.5. The medical device of claim 1 , wherein the distal locking portion comprises an internally threaded distal screw and wherein the proximal locking portion comprises an internally threaded ...

CLOSING OPENINGS IN ANATOMICAL TISSUE

A device for closing at least one opening leading to an anatomical cavity is delivered via a catheter positioned in a first opening leading to the anatomical cavity. An orientation control unit is positioned within the anatomical cavity. The orientation control unit defines an orientation of a portion of a tissue surface within the anatomical cavity that is skewed with respect to the first opening and orients a closure member of the device with the tissue surface. An occluding member and a constricting unit of the device are positioned within the anatomical cavity with the occluding member blocking a portion of an opening that is constricted by the constricting unit. An intermediate member of the device is positioned within the anatomical cavity and a closure unit employing at least one piercing element pierces through the intermediate member into a tissue wall surrounding the anatomical cavity. 1. (canceled)2. A medical system configured to close one or more openings , each of the one or more openings leading to an anatomical cavity , at least a portion of the medical system sized in at least one configuration for passage through a first opening of the one or more openings into the anatomical cavity , and the at least the portion of the medical system comprising:a closure unit arranged to be delivered into the anatomical cavity to a location at least proximate an interior tissue surface within the anatomical cavity, the closure unit further arranged to close an opening of the one or more openings located on the interior tissue surface within the anatomical cavity; andan intermediate member arranged to be delivered into the anatomical cavity to a location between at least part of the closure unit and the interior tissue surface within the anatomical cavity,wherein the closure unit comprises at least one piercing element, each of the at least one piercing element arranged to pierce through the intermediate member and pierce into the interior tissue surface within the ...

SYSTEM AND METHOD FOR TRANSAPICAL ACCESS AND CLOSURE

Embodiments are described for creating and closing tissue access ports, such as transapical access ports, which involve placement of an introducer across the subject tissue structure, and deployment of a controllable port closure device assembly configured to remain in place with a ratcheting mechanism, and to hold the tissue surrounding the previous access port location closed against a sealing disc with proximal and distal strut assemblies, after the introducer has been removed. 1a. a base member having a proximal end and a distal end and an externally projecting seal member disposed therebetween and configured to interface with at least a portion of the tissue wall to assist in sealing the defect, the proximal end being configured to be manually manipulated by an operator;wherein the externally projecting seal member defines an outer seal margin defining an outer seal diameter; 'wherein in the collapsed configuration, each of the bendable strut members project out from a coupling junction with the distal portion of the base member, sweep toward the proximal end of the base member, and bend toward the outer seal margin;', 'b. a first plurality of bendable strut members coupled to the distal end of the base member and configured to occupy a collapsed configuration when bent in place toward the base member, and an expanded configuration when unrestrained;'}c. a proximal hub member movably and coaxially coupled about the outside of the base member and advanceable along a length of the base member; and 'wherein in the collapsed configuration, each of the bendable strut members project out from a coupling junction with the proximal hub member and sweep toward the distal end of the base member.', 'd. a second plurality of bendable strut members coupled to the proximal hub member and configured to occupy a collapsed configuration when bent in place toward the base member, and an expanded configuration when unrestrained;'}. An apparatus for closing a defect in a tissue ...

Tissure Closure Device and Method

A device having a plurality of anchors configured to be driven into a tissue, and a closure element extending between the anchors and configured to urge the anchors toward each other, closing a wound and complying with motion of the tissue. 1. A method , comprising:implanting a plurality of anchors into tissue; andurging the implanted anchors towards each other by at least one elastic closure element coupled to the anchors with sufficient force to (a) close an aperture and/or a distance in the tissue located between the implanted anchors and (b) resist opposing forces exerted on the implanted anchors that urge the anchors apart and/or the aperture open.2. The method according to claim 1 , wherein the opposing forces are exerted on the anchors by at least one of (a) the tissue claim 1 , (b) a fluid flow claim 1 , (c) pneumatic pressure claim 1 , (d) hydraulic pressure claim 1 , and (e) external forces.3. A method claim 1 , comprising:implanting a plurality of anchors into tissue;urging the implanted anchors towards each other by at least one elastic closure element coupled to the anchors;forming an aperture in the tissue between the implanted anchors, the elastic closure element urging the implanted anchors towards each other and towards the aperture with sufficient force to (a) maintain the aperture in the tissue in a closed position and (b) resist opposing forces exerted on the implanted anchors that urge the anchors apart and urges the aperture open;inserting an instrument through the aperture; andafter removing the instrument from the aperture, again urging the implanted anchors towards each other and towards the aperture by the elastic closure element with sufficient force to (a) maintain the aperture in the tissue in the closed position and (b) resist opposing forces exerted on the implanted anchors that urge the anchors apart and the aperture open.4. The method according to claim 3 , wherein the opposing forces are exerted on the anchors by at least one of (a) ...

Implantable sealing device

A method for sealing a tissue opening includes inserting a trocar tube including a folded sealing device disposed within the trocar, and guiding the trocar tube through an opening in a myocardium into a patient's ventricle, the sealing device can include an elongated elastic member having a distal and a proximal end, a proximal umbrella shaped braiding extending radially from the elongated elastic member, the proximal braiding being positioned at the proximal end of the elastic member, wherein the proximal braiding includes a proximal disc disposed therein having a proximal disc thread disposed therethrough such that a user can pull the proximal braiding, and a distal umbrella shaped braiding extending radially from the elongated elastic member and being positioned at the distal end of the elastic member opposite to the proximal braiding.

FIXATION DEVICES, SYSTEMS AND METHODS FOR ENGAGING TISSUE

The invention provides devices, systems and methods for tissue approximation and repair at treatment sites. The devices, systems and methods of the invention will find use in a variety of therapeutic procedures, including endovascular, minimally-invasive, and open surgical procedures, and can be used in various anatomical regions, including the abdomen, thorax, cardiovascular system, heart, intestinal tract, stomach, urinary tract, bladder, lung, and other organs, vessels, and tissues. The invention is particularly useful in those procedures requiring minimally-invasive or endovascular access to remote tissue locations, where the instruments utilized must negotiate long, narrow, and tortuous pathways to the treatment site. In addition, many of the devices and systems of the invention are adapted to be reversible and removable from the patient at any point without interference with or trauma to internal tissues. 1. A fixation system for engaging leaflets of a heart valve comprising:a catheter having an elongated shaft, a proximal end and a distal end, the catheter configured to pass from remote vasculature of a patient to a location within the patient's body near the leaflets; and a fixation device detachably coupled to the distal end of the catheter;a central spacer of the fixation device having engagement portions for engaging the leaflets, the spacer configured to be disposed between the leaflets when the leaflets are engaged;a pair of clasping elements movably integrated with the fixation device, each clasping element moveable with respect to one of the engagement portions and configured to be moved into opposition with one of the engagement portions so as to capture a leaflet therebetween, each clasping element being cantilevered from the fixation device and resiliently biased to move toward one of the engagement portions of the central spacer; andan actuator configured to move the pair of clasping elements to a first position where the clasping elements are ...

SYSTEMS AND METHODS FOR TREATING FISTULAS IN THE LUNG AND TRACHEA

In certain embodiments, a device is configured to be compressed and inserted into the distal end of an endoscope. The delivery device can be configured to deliver the delivery catheter to the site of one or more fistulas in the wall of a body cavity or lumen within a patient. The delivery catheter is configured to deliver the device to the site of the one or more fistulas. The device is configured to expand at the site of the one or more fistulas and substantially seal the fistula in one or more directions. In some embodiments, at least a portion of the device is coated with and/or constructed of biocompatible material. In some configurations, the device is configured to be implanted for an extended period of time or even permanently. In some embodiments, at least a portion of the device is constructed of biodegradable, dissolvable and/or bioabsorbable material. 1. A device for treating fistulas in walls of a body cavity or lumen , the device configured to transition between a compressed and an expanded configuration , the device further configured to fit within a working channel of an endoscope with the device is in a compressed configuration , the device comprising:one or more conical portions, the one or more conical portions configured to transition between a compressed and an expanded configuration, the one or more conical portions configured to restrict the flow of fluid through a fistula in at least one direction when the one or more conical portions are in an expanded configuration and deployed at the site of a fistula; andone or more hub portions, the hub portion comprising a first end and a second end, the one or more hub portions configured to connect to at least one of the one or more conical portions.2. The device of claim 1 , wherein the device further comprises a rod portion claim 1 , the rod portion connected to the one or more conical portions and/or the one or more hub portions.3. The device of claim 1 , wherein the device comprises two conical ...

System for left atrial appendage occlusion

Disclosed is an occlusion device for use in a body lumen such as the left atrial appendage. The occlusion device includes an occlusion member and may also include a stabilizing member. The stabilizing member inhibits compression of the left atrial appendage, facilitating tissue in-growth onto the occlusion member. Methods are also disclosed.

Medical device for modification of left atrial appendage and related systems and methods

A medical device and system for modifying a left atrial appendage (“LAA”), as well as related methods, are provided. In accordance with one embodiment, a medical device includes a plurality of frame segments coupled with at least one ring member, the at least one ring member having an inner surface defining notches radially spaced therein, each of the frame segments configured to be positioned within one of the notches of the at least one ring member to collectively form a frame structure. Each frame segment includes a hub portion and at least one leg portion, the hub portion having an upper surface configured to be captured in one of the notches defined in the at least one ring member, and the at least one leg portion extending from the hub portion. With this arrangement, a tissue growth member is coupled to the frame segments.

APICAL PUNCTURE ACCESS AND CLOSURE SYSTEM

A device, system, and method for providing access to, and sealing of, a body organ includes an implant device. An implant device has a main body having an internal access lumen, with a plurality of prongs extending from a distal end of the main body. The main body can include two lumens, one slidable within the other, to form a single continuous lumen with an adjustable length. The main body has an expanded configuration with an expanded diameter, and an unexpanded configuration with an unexpanded diameter. The prongs have a generally straight configuration where they extend distally of the distal end of the main body, and a bent configuration where the prongs bend around so that their tips extend proximally of the distal end of the main body. The device may include a hemostatic barrier to prevent fluid leakage therethrough when the main body is in the unexpanded configuration. 1. A device for providing access through and sealing of a puncture in tissue , comprising:a generally elongated and radially-expandable main body, the main body comprising a distal portion having a distal end and a distal lumen and a proximal portion having a proximal end and a proximal lumen, the distal lumen being sized to receive the proximal lumen, thereby creating a continuous internal lumen through the main body, the main body having an unexpanded configuration having an unexpanded outer diameter, the main body further having an expanded configuration having an expanded outer diameter;a plurality of prongs extending from the distal end of the distal portion of the main body, each of the prongs comprising a proximal end secured to the distal end of the distal portion of the main body, each of the prongs further comprising a distal end, wherein each of the prongs comprises a straight configuration wherein the prong is generally straight and extends generally distally from the main body distal portion such that the distal end of the prong is positioned distally of the main body, each of ...

Devices and methods for excluding the left atrial appendage

Systems, devices and methods for occluding the left atrial appendage (LAA). The device excludes the LAA from blood flow. The implantable device is delivered via transcatheter delivery into the LAA and secured within the LAA. The implant comprises an expandable and compliant frame and an expandable and conformable tubular foam body. A delivery and tether retraction system includes a handle for controlling a pusher and tether. The pusher may be moved a distance away from the implant without changing the orientation of the implant, while the tether is still attached to the implant. Severing the tether and proximally retracting a control on the hand piece by a distance causes the severed end to advance distally by at least about twice that distance. A loader includes a conical portion with guides and a reservoir for submerging the foam prior to loading and delivery.

Fixation devices, systems and methods for engaging tissue

System for fixation of leaflets of a heart valve including a delivery catheter having an elongated shaft, a proximal end portion and a distal end portion configured to be positioned proximate native leaflets of a heart valve from a remote vascular access point, the delivery catheter further includes a rotatable actuator rod having a threaded fastener at a distal end thereof, and a fixation device releasably coupled by a threaded connection to the threaded fastener of the actuator rod. The fixation device includes a first arm moveable between a closed position and an open position, a second arm moveable between a closed position and an open position. The fixation device further includes a first gripping element movable relative to the first arm in the open position, the first gripping element biased toward the first arm to capture a first leaflet of the heart valve therebetween, and a second gripping element movable relative to the second arm in the open position, the second gripping element biased toward the second arm to capture a second leaflet of the heart valve therebetween. The first gripping element and the second gripping element each includes a plurality of barbs extending therefrom, the plurality of barbs of each of the first gripping element and the second gripping element being aligned transversely in at least one row. The fixation device further includes a covering disposed on each of the first gripping element and the second gripping element, wherein the plurality of barbs of the first gripping element and the second gripping element, respectively, protrude through the covering.

INTERCOSTAL DELIVERY SYSTEM AND METHODS THEREOF

The invention discloses a delivery device for use in surgery on an organ in a living body. The delivery device is characterized by a proximal and a distal end inter-connected by a main longitudinal axis, the distal end comprising: (a) at least one anchoring device, comprising at least one tissue anchor; and (b) at least one pivoting support in communication with the anchoring device. The anchoring device can pivot freely around the pivoting support independent of the orientation of the pivoting support with respect to the organ, such that the anchoring device can be oriented substantially parallel to and conform to the surface of the organ with which the anchoring device comes into contact. 2. The delivery device of claim 1 , wherein said anchoring device is adapted to pivot around said pivoting support in at least two orthogonal degrees of freedom claim 1 , said degrees of freedom for reorientation of said anchoring device selected from a group consisting of (a) rotation about an axis substantially perpendicular to said main longitudinal axis and substantially parallel to said pivoting supports claim 1 , (b) rotation about an axis substantially perpendicular to said main longitudinal axis and substantially perpendicular to said pivoting supports claim 1 , and (c) along said main longitudinal axis.3. The delivery device of claim 1 , wherein at least one of the following is being held true:a. the longitudinal axes of said at least one tissue anchor is substantially perpendicular to the plane of said surface4. The delivery device of claim 1 , wherein at least one of the following is being held true:a. said anchoring device comprises at least one surface;b. said surface comprises a loop-like coil of closed periphery;c. said surface has at least two configurations: (i) an open configuration and (ii) a closed configuration;d. said anchoring device is able to elastically deform from said open configuration to said closed configuration;e. said anchoring device is adapted ...

VASCULAR CLOSURE DEVICE

A device for closure of an opening formed through a wall of a body vessel of a patient is provided, as well as an introducer system for delivery of the closure device. Various embodiments include the closure device having hook members configured to engage the tissue interior of the body vessel wall, hook members configured to engage interstitial tissue adjacent to the body vessel, a plug member to contact sealably the opening from inside the body vessel, and combinations thereof. A retraction member is removably attached to the each of the embodiments to permit manipulation of the device. Remodelable material may be included with each of the embodiments to promote quicker healing. The introducer includes a sheath that is insertable through the opening and a pusher disposed within the lumen of the sheath and movable within the sheath lumen to deploy the device. 1. A device for closure of an opening formed through a wall of a body vessel of a patient , comprising:an anchor body having a proximal end and a distal end, the proximal end including a plurality of hook members configured to engage interstitial tissue adjacent to said body vessel to inhibit movement of the anchor body,wherein the anchor body is movable between a contracted configuration and an extended configuration, where in the contracted configuration the anchor body is sized to fit within a channel through said interstitial tissue, and in the extended configuration the hook members of the anchor body are displaced outward to a cross-sectional area greater than the cross-sectional area of said opening;a plug member attached to the anchor body distal end, the plug member sized to at least substantially fill said opening; anda retraction member removably attached to a portion of the anchor body, wherein the retraction member is retractable to bring the plug member in sealably contact with said opening.2. The device of claim 1 , wherein the hook members of the anchor body in the extended configuration are ...

PERCUTANEOUS CATHETER DIRECTED INTRAVASCULAR OCCLUSION DEVICES WITH RETRACTABLE STABILIZING WIRES

A medical device is provided in which one or both ends of the device encourage the formation of tissue across substantially the entire area of the respective end that is exposed to the blood flow for reducing the risk of a thrombotic embolism. The medical device further includes stabilizing wires configured to engage tissue at a target site when the medical device is in an expanded configuration and to at least partially retract into the medical device when the medical device is in a collapsed configuration. 1. A medical device configured to self-expand from a contracted state when constrained within a delivery device toward an expanded state when deployed from the delivery device for delivery to a target site within the body lumen , the medical device comprising:a tubular structure comprising a plurality of braided strands, each braided strand comprising a proximal strand end and a distal strand end, the tubular structure comprising an expanded volume portion defining an expanded volume diameter in the expanded state; anda plurality of retractable stabilizing wires that extend from the expanded volume portion in the expanded state.2. The medical device of claim 1 , wherein claim 1 , in the contracted state claim 1 , the expanded volume portion defines a contracted diameter.3. The medical device of claim 2 , wherein claim 2 , in the contracted state claim 2 , the retractable stabilizing wires are maintained at least partially within the contracted diameter of the expanded volume portion.4. The medical device of claim 3 , wherein the retractable stabilizing wires comprise a bend so as to create two interconnected stabilizing wires each having an end portion.5. The medical device of claim 4 , wherein the bend is fixedly attached to the expanded volume portion.6. The medical device of claim 4 , wherein the end portions are slidably attached to the expanded volume portion.7. The medical device of claim 6 , wherein each end portion is configured to engage tissue at a ...

METHOD OF CLOSING AN OPENING IN A WALL OF THE HEART

Disclosed is a closure catheter, for closing a tissue opening such as an atrial septal defect, patent foreman ovale, or the left atrial appendage of the heart. The closure catheter carries a plurality of tissue anchors, which may be deployed into tissue surrounding the opening, and used to draw the opening closed. Methods are also disclosed. 1. A method of preventing passage of embolic material from a left atrial appendage, comprising: positioning a patch across an opening of the left atrial appendage; and securing the patch at one or more locations surrounding the opening of the left atrial appendage. This application is a continuation of application Ser. No. 14/101,122, filed Dec. 9, 2013, which is a continuation of application Ser. No. 13/477,404, filed May 22, 2012, now U.S. Pat. No. 8,603,108, which is a continuation of application Ser. No. 11/880,265, filed on Jul. 20, 2007, which is a continuation of application Ser. No. 10/810,990, filed Mar. 26, 2004, now U.S. Pat. No. 7,780,683, which is a continuation of application Ser. No. 09/904,790, filed on Jul. 13, 2001, now U.S. Pat. No. 6,712,804, which is a divisional of application Ser. No. 09/444,904, filed on Nov. 22, 1999, now U.S. Pat. No. 6,290,674, which is a continuation-in-part of application Ser. No. 09/399,521, filed Sep. 20, 1999, now U.S. Pat. No. 6,231,561.The present invention relates to methods and devices for closing a body lumen, tissue opening, or cavity and, in particular, for closing an atrial septal defect.Embolic stroke is the nation's third leading killer for adults, and is a major cause of disability. There are over 700,000 strokes per year in the United States alone. Of these, roughly 100,000 are hemoragic, and 600,000 are ischemic (either due to vessel narrowing or to embolism). The most common cause of embolic stroke emanating from the heart is thrombus formation due to atrial fibrillation. Approximately 80,000 strokes per year are attributable to atrial fibrillation. Atrial ...

RETRIEVAL WIRE CENTERING DEVICE

An occlusive implant system may include a catheter having a lumen extending therethrough, a core wire slidably and rotatably disposed within the lumen, the core wire having a threaded member disposed at a distal end, and a medical implant having an expandable frame, an occlusive element disposed on the frame, and a threaded insert coupled to a proximal portion of the frame, wherein the threaded member is removably coupled to the threaded insert. 1. An occlusive implant system , comprising:a catheter having a lumen extending therethrough;a core wire slidably and rotatably disposed within the lumen, the core wire having a threaded member disposed at a distal end thereof; anda medical implant having an expandable frame, an occlusive element disposed on the expandable frame, and a threaded insert coupled to a proximal portion of the expandable frame;wherein the threaded member is removably coupled to the threaded insert.2. The occlusive implant system of claim 1 , wherein a portion of the occlusive element is disposed between the threaded insert and the proximal portion of the expandable frame.3. The occlusive implant system of claim 1 , wherein a portion of the occlusive element extends proximally of the threaded insert.4. The occlusive implant system of claim 1 , wherein the core wire includes a guide element disposed adjacent a proximal end of the threaded member claim 1 , the guide element being configured to center the core wire within the catheter.5. The occlusive implant system of claim 4 , wherein the guide element includes a convex proximal surface and a generally flat distal surface.6. The occlusive implant system of claim 4 , wherein the guide element includes a conical proximal surface and a generally flat distal surface.7. The occlusive implant system of claim 4 , wherein the guide element includes a generally rounded convex outer surface.8. The occlusive implant system of claim 4 , wherein the guide element is disposed about the core wire.9. The occlusive ...

APPARATUS AND METHOD FOR TISSUE ADHESION

An array of a plurality of shape memory material microposts have a proximal end configured to be secured to a substrate with a tissue penetrating distal end. The microposts further have a deployment state with the microposts in a substantially straightened configuration with a substantially smooth and continuous outer surface which is substantially parallel to adjacent microposts and an engaged state wherein at least a section of the microposts assume a configuration that is not substantially parallel to adjacent microposts or is not substantially straight with a substantially smooth and continuous outer surface so as to mechanically capture tissue adjacent thereto 1. A method for treating an aneurism , comprising:providing an elastically expandable balloon substrate having a contact surface;forming an array of microposts extending from the contact surface of the balloon substrate, said microposts fabricated from a shape memory material and having a proximal end secured to the substrate, and a sharpened tissue penetrating distal end;elastically expanding the balloon substrate by inflation thereby deploying the microposts into the tissue of the aneurism, the microposts being disposed in a substantially straightened configuration, being substantially perpendicular to the substrate, and being substantially parallel to adjacent microposts;engaging the microposts by activation of the shape memory material after penetration into the tissue of the aneurism wherein a distal section of each micropost mechanically captures tissue adjacent thereto and said microposts are no longer substantially parallel to adjacent microposts and no longer in a straightened configuration;deflating the balloon substrate thereby causing closure of the balloon substrate and tissue of the aneurism.2. The method of further comprising sealing the deflated balloon substrate upon itself via self-adhering internal surfaces.3. The method of wherein sealing the deflated balloon substrate upon itself via ...

OCCLUSIVE MEDICAL DEVICE WITH FABRIC RETENTION BARB

An occlusive implant system may include a catheter having a lumen extending from a proximal opening to a distal opening, a core wire slidably disposed within the lumen, and an occlusive implant having an expandable framework configured to shift between a collapsed configuration and an expanded configuration, and an occlusive element disposed on the expandable framework. The expandable framework may include a plurality of anchor members extending radially outward from the expandable framework, at least some of the plurality of anchor members each have a barb projecting circumferentially therefrom. The occlusive implant may be releasably connected to a distal portion of the core wire. 1. An occlusive implant , comprising:an expandable framework configured to shift between a collapsed configuration and an expanded configuration; andan occlusive element disposed on the expandable framework;wherein the expandable framework includes a plurality of anchor members extending radially outward from the expandable framework;wherein at least some of the plurality of anchor members each have a barb projecting circumferentially therefrom.2. The occlusive implant of claim 1 , wherein each of the plurality of anchor members includes a body portion and a tip portion.3. The occlusive implant of claim 2 , wherein the barb projecting circumferentially from at least some of the plurality of anchor members projects from the body portion of its respective anchor member.4. The occlusive implant of claim 2 , wherein the body portion of each anchor member is attached to the expandable framework at a base of its respective anchor member.5. The occlusive implant of claim 2 , wherein each barb includes a forward surface facing towards the tip portion of its respective anchor member claim 2 , and a rear surface facing towards the base of its respective anchor member.6. The occlusive implant of claim 5 , wherein the rear surface is positioned at an obtuse angle to the body portion.7. The occlusive ...

Medical device for modification of left atrial appendage and related systems and methods

A medical device and system for modifying a left atrial appendage (“LAA”), as well as related methods, are provided. In accordance with one embodiment, a medical device includes a plurality of frame segments coupled with at least one ring member, the at least one ring member having an inner surface defining notches radially spaced therein, each of the frame segments configured to be positioned within one of the notches of the at least one ring member to collectively form a frame structure. Each frame segment includes a hub portion and at least one leg portion, the hub portion having an upper surface configured to be captured in one of the notches defined in the at least one ring member, and the at least one leg portion extending from the hub portion. With this arrangement, a tissue growth member is coupled to the frame segments.

LEFT ATRIAL APPENDAGE PLUGGING DEVICE AND DELIVERY SYSTEM

A left atrial appendage occlusion device and a delivery system are provided, wherein the left atrial appendage occlusion device includes a stent and an occluder. Firstly, the stent is implanted and fixed at the entrance of the left atrial appendage; then, a double-disc occluder is released on the stent to occlude the left atrial appendage. The left atrial appendage occlusion device includes a self-expandable nitinol stent, which is firmly fixed at the entrance of the left atrial appendage via a two-way anchoring thorn, and then an occluder is released on the stent. The left atrial appendage occlusion device is delivered to the left atrial appendage by the delivery system. Compared with the prior art, the delivery system improves the releasing accuracy and the implanting stability of the occluder. After being released, both the stent and the occluder can be withdrawn into a catheter to be relocated or replaced. 1. A left atrial appendage occlusion device , comprising:a stent configured to be released and fixed at an entrance of a left atrial appendage to establish an artificial position for fixing an occluder; andan occluder configured to be released and fixed to the stent to occlude the left atrial appendage.3. The left atrial appendage occlusion device according to claim 2 , wherein the stent comprises the flexible support rods at a periphery of the stent and the nickel-titanium alloy tube; andthe flexible support rods form a proximal end disk and a distal end disk which has the same shape and structure, and the two discs are respectively connected to two nickel-titanium alloy tubes having the same size.4. The left atrial appendage occlusion device according to claim 3 , wherein support rods at a periphery of each of the two disks of the stent form a regular polygon claim 3 , and axial support rods are provided at vertexes of the polygons of the two disks to connect the support rods at the peripheries of the two discs.5. The left atrial appendage occlusion device ...

Intracardiac cage and method of delivering same

A method of preventing ingress of material into the left atrium of a heart includes providing a delivery sheath, advancing the sheath distal end through an opening between the right atrium and the left atrium of the heart, providing an expandable cage, delivering the expandable cage to the left atrium, and expanding the expandable cage within the left atrium. The expandable cage includes a proximal end, a distal end, and a plurality of supports extending therebetween. The expandable cage also includes a first membrane provided at its proximal end and a second membrane provided at its distal end. The expandable cage has a collapsed configuration so that it can be received within the lumen of the delivery sheath, and an expanded configuration for deployment within the heart. When expanded, the first membrane is positioned at an opening between the left and right atria of the heart, and the second membrane is positioned at the ostium of the left atrial appendage. The first membrane substantially prevents passage of blood between the atria and the second membrane prevents passage of embolic material from the left atrial appendage into the left atrium of the heart.

Uncoupled LAA Device

A medical device for treating an LAA is presented. The device includes a cap, a bulb and a joint assembly therebetween. The cap is a three layer mesh structure with a retaining hub securing the layers together. A plurality of proximal wire loops extend from the base layer to a proximal post of the joint assembly. The bulb has a plurality of distal wire loops that extend between a terminal post and a distal post of the joint assembly. The joint assembly comprises a first ball joint, a second ball joint and a housing. Each ball joint is retained in the housing independent ball and socket relationships. Each ball joint and post defines a longitudinal axis. The housing defines a housing longitudinal axis. By way of the ball and socket relationship each ball joint longitudinal axis may form an angle of between about 0 to about 35 degrees with the housing longitudinal axis in any direction. 1. A medical device to treat the LAA , the medical device having a deployed state and a confined state , the medical device comprising:a cap, a bulb and a joint assembly therebetween;the cap having a plurality of layers, a plurality of proximal wire loops extending from the cap to a proximal post of the joint assembly;the bulb having a plurality of distal wire loops that extend between a terminal post and a distal post of the joint assembly, adjacent distal wire loops being connected one to another by at least one connection collar;the joint assembly comprising a first ball joint, a second ball joint and a housing, the proximal post extending proximally from the first ball joint, the distal post extending distally from the second ball joint, the housing having a proximal collar and a distal collar, the proximal collar retaining the first ball joint in a first ball and socket relationship, the distal collar retaining the second ball joint in a second ball and socket relationship;the housing having a housing longitudinal axis extending therethrough, a proximal longitudinal axis extending ...

Inflatable device for enteric fistula treatment

Disclosed herein is an implantable fistula closure device. The device may include an expandable longitudinally segmented body including a proximal end and a distal end. The segmented body may further include a plurality of porous bodies and a connecting member operably joining together the plurality of porous bodies. The plurality of porous bodies includes a first porous body with a proximal end and a distal end and a second porous body with a proximal end and a distal end, and the connecting member operably connects the proximal end of the first porous body with the distal end of the second porous body.

Fixation devices, systems and methods for engaging tissue

A fixation device (10) for engaging tissue (LF) comprising: a pair of fixation elements (16,18) each having a first end, a free end opposite the first end, and an engagement surface therebetween for engaging the tissue, the first ends being movably coupled together such that the fixation elements are moveable between a closed position wherein the engagement surfaces face each other to an inverted position wherein the engagement surfaces face away from each other; and an actuation mechanism (12) coupled to the fixation elements adapted to move the fixation elements between the closed position and the inverted position.

Methods and apparatus for cardiac valve repair

The methods, devices, and systems are provided for performing endovascular repair of atrioventricular and other cardiac valves in the heart. Regurgitation of an atrioventricular valve, particularly a mitral valve, can be repaired by modifying a tissue structure selected from the valve leaflets, the valve annulus, the valve chordae, and the papillary muscles. These structures may be modified by suturing, stapling, snaring, or shortening, using interventional tools which are introduced to a heart chamber. Preferably, the tissue structures will be temporarily modified prior to permanent modification. For example, opposed valve leaflets may be temporarily grasped and held into position prior to permanent attachment.

Methods and devices for capturing and fixing leaflets in valve repair

The present invention provides methods and devices for grasping, and optional repositioning and fixation of the valve leaflets to treat cardiac valve regurgitation, particularly mitral valve regurgitation. Such grasping will typically be atraumatic providing a number of benefits. For example, atraumatic grasping may allow repositioning of the devices relative to the leaflets and repositioning of the leaflets themselves without damage to the leaflets. However, in some cases it may be necessary or desired to include grasping which pierces or otherwise permanently affects the leaflets. In some of these cases, the grasping step includes fixation.

Methods and apparatus for cardiac valve repair

Method and device for closing holes in tissue

A device for closing holes in tissue is delivered via a catheter to the inside of a body lumen such as a heart. An elastic barbed clip is expanded, pulled into the tissue and released, pulling the tissue with it. The operation is fully reversible.

Closing openings in anatomical tissue

A device for closing at least one opening leading to an anatomical cavity is delivered via a catheter positioned in a first opening leading to the anatomical cavity. An orientation control unit, positioned within the anatomical cavity, an orientation of a portion of a tissue surface within the anatomical cavity that is skewed with respect to the first opening and orients a closure member of the device with the tissue surface. An occluding member and a constricting unit are positioned within the anatomical cavity, the occluding member blocking a portion of an opening that is constricted by the constricting unit. An intermediate member of the device is positioned within the anatomical cavity and a closure unit employing at least one piercing element pierces through the intermediate member into a tissue wall surrounding the anatomical cavity.

RETRIEVAL WIRE CENTERING DEVICE

An occlusive implant system may include a catheter having a lumen extending therethrough, a core wire slidably and rotatably disposed within the lumen, the core wire having a threaded member disposed at a distal end, and a medical implant having an expandable frame, an occlusive element disposed on the frame, and a threaded insert coupled to a proximal portion of the frame, wherein the threaded member is removably coupled to the threaded insert. 1. A medical implant , comprising:a frame configured to actuate between a collapsed configuration and an expanded configuration,wherein the expanded configuration of the frame is compliant and is configured to substantially conform to a shape and/or geometry of a lateral wall of a left atrial appendage; and to be in sealing engagement therewith when implanted in the left atrial appendage;an occlusive element configured to cover at least a proximal portion of the frame, which proximal portion spans an opening formed by the lateral wall of the left atrial appendage in the expanded configuration of the frame, and is configured to cover at least a portion of the lateral wall of the left atrial appendage distal of the opening;wherein a proximal end of the frame includes a generally tubular portion, the generally tubular portion being configured to attach to a distal end of a core wire;wherein the generally tubular portion of the frame includes a threaded insert coupledthereto,wherein a proximalmost extent of the threaded insert is substantially coplanar with a plane defined by three or more proximalmost extents of the frame in the expanded configuration,wherein the portion of the occlusive element covering the opening is substantially coplanar with the proximalmost extent of the threaded insert and the plane defined by the proximalmost extent of the frame in the expanded configuration.2. The medical implant of claim 1 , wherein the frame includes an annular collar member at least partially disposed within the generally tubular ...

System and method for delivering a left atrial appendage containment device

A device for containing emboli within a left atrial appendage of a patient includes a frame that is expandable from a reduced cross section to an enlarged cross section and a slider assembly. The frame extends between a proximal hub and a distal hub, and the slider assembly is coupled to the distal hub of the frame. The slider assembly includes a guide tube that has a channel extending proximally away from the distal hub, and a nut. The nut is longitudinally moveable within the channel of the guide tube over a predetermined distance relative to the guide tube. The nut is operable to be releasably coupled with an elongate core, and movement of the nut relative to the guide tube is at least partially limited by interference between a portion of the nut and a portion of the guide tube.

IMPLANT FOR CLOSING AN OPENING IN TISSUE

An implant for closing an opening in tissue such as a fistula or a sinus comprises a coil having a substantially uniform outer diameter. The coil forms an internal passage having a diameter that tapers from a distal end to a proximal end. The implant may be delivered using a non-tapered driver coil

OCCLUSIVE MEDICAL DEVICE WITH FABRIC RETENTION BARB

An occlusive implant system may include a catheter having a lumen extending from a proximal opening to a distal opening, a core wire slidably disposed within the lumen, and an occlusive implant having an expandable framework configured to shift between a collapsed configuration and an expanded configuration, and an occlusive element disposed on the expandable framework. The expandable framework may include a plurality of anchor members extending radially outward from the expandable framework, at least some of the plurality of anchor members each have a barb projecting circumferentially therefrom. The occlusive implant may be releasably connected to a distal portion of the core wire. 1. An occlusive implant , comprising:an expandable framework configured to shift between a collapsed configuration and an expanded configuration that is configured to conform to and to be in a sealing engagement with a lateral wall of a left atrial appendage; andan occlusive element disposed on the expandable framework;wherein the expandable framework includes a plurality of anchor members extending radially outward from the expandable framework and extending through the occlusive element;wherein each of the plurality of anchor members includes a base attached to the expandable framework, a proximal body portion extending from the base, and a distal tip portion adapted to engage tissue;wherein at least some of the plurality of anchor members have at least one barb projecting radially and/or axially therefrom at a point distal of the base of the respective anchor member.2. The occlusive implant of claim 1 , wherein each barb projects transverse claim 1 , lateral claim 1 , and/or perpendicular to the proximal body portion.3. The occlusive implant of claim 2 , wherein each barb projects perpendicular to the proximal body portion.4. The occlusive implant of claim 1 , wherein each barb extends exterior of the occlusive element claim 1 , thereby retaining the occlusive element on the ...

Methods and apparatus for cardiac valve repair

The methods, devices, and systems are provided for performing endovascular repair of atrioventricular and other cardiac valves in the heart. Regurgitation of an atrioventricular valve, particularly a mitral valve, can be repaired by modifying a tissue structure selected from the valve leaflets, the valve annulus, the valve chordae, and the papillary muscles. These structures may be modified by suturing, stapling, snaring, or shortening, using interventional tools (30, 36, 56) which are introduced to a heart chamber. Preferably, the tissue structures will be temporarily modified prior to permanent modification. For example, opposed valve leaflets may be temporarily grasped and held into position prior to permanent attachment.

Devices and methods for treating fistulae and other bodily openings and passageways

本发明的一些方面涉及用于治疗瘘以及身体中的其它通道和开口的独特产品和方法。在一些优选形式中，发明的结构将包括细长移植本体，该细长移植本体包括多个片材或片材状区段。在一些结构中，该多个片材或片材状区段将沿塞子本体的长度沿大致纵向方向堆叠，也可选择，区段将接收在一个或多个细长元件上面。这种细长元件采取多种形式，包括缝合线、线、丝线或者其它相对细体的细长部件，尽管在一些形式中，细长元件将是或包括稍微更重的结构，例如可生物降解或不可生物降解的三维本体。

Patent foramen ovale closure system

A patent foramen ovale closure device, method of delivering and a delivery system are provided. The device may include a closure device releasably connectable to an actuator. The device may include a proximal segment, an intermediate segment and a distal segment. When delivered, the proximal segment and intermediate segment form a first clip-shaped portion sized and configured to be positioned over a septum secundum of the patent foramen ovale, and the intermediate segment and distal segment form a second clip-shaped portion sized and configured to be positioned over a septum primum of the patent foramen ovale.

Transcatheter valve delivery system with septal penetration hole closure tip assembly

Inflatable device for enteric fistula treatment

本发明公开了一种可植入式瘘闭合装置。该装置可包括可扩张的沿纵向分段的体部，该体部包括近端和远端。该分段的体部还可包括多个多孔体部和将多个多孔体部可操作地连结在一起的连接部件。多个多孔体部包括具有近端和远端的第一多孔体部，以及具有近端和远端的第二多孔体部，且连接部件将第一多孔体部的近端与第二多孔体部的远端可操作地连接。

Left atrial appendage occluder (versions)

FIELD: medical equipment. SUBSTANCE: group of inventions relates to an implantable medical device and, in particular, relates to a high-efficiency, reliably fixed and fatigue-resistant occluder of the left atrial appendage with repeated deployment, which enables occlusion of left atrial appendage and prevents thrombosis in left atrial appendage. Left occlusion ear occluder comprises a sealing element, a fastening element and a tubular element. Tubular element has first end and second end. First end of the tubular element is attached to the fastening element, and the second end of the tubular element is attached to the sealing element. Fastening element comprises support rods. Each support rod has a proximal end and a distal end. Proximal end of each support rod is connected to the first end of the tubular element, and the far end of the support rod comes out of the tubular element. In extended state of occluder support rods cross one another along cylindrical axis of tubular element. At that the support rods are located radially along the circumference of the tubular element. Each support rod forms an angle α with cylindrical axis of tubular element, wherein angle α makes 40–55°. First, each support rod exits tubular element, and then, after bending, passes in direction of tubular member so that parts of each support rod, passing in direction of tubular element, form periphery of fastener. According to the second embodiment, the occlusion of the left atrial appendage comprises only a fastening element and a tubular element. Fastening element is attached to the tubular element for fixation in the body cavity, and the proximal end of each support rod is connected to one end of the tubular element. EFFECT: embodiments of the invention are aimed at providing an effective, reinstallable, reliably fixed and fatigue-resistant occluder of the left atrial appendage for left atrial appendage (LAA) occlusion and thrombotic flow blocking in left atrial appendage. 15 cl, 11 dwg ...

Needle apparatus for closing septal defects and methods for using such apparatus

Apparatus and methods for closing a septal defect including a flap of tissue partially detached from a septum of a heart. A needle is advanced through a patient's vasculature within a delivery apparatus until the needle is disposed within a first chamber adjacent the septum. The needle is directed through the flap of tissue until the needle is disposed within a second chamber opposite the septum. A filament attached to an intermediate region of the needle is pulled, thereby causing the needle to pivot about the intermediate region such that the ends of the needle straddle the septal opening. A locking element is secured to the filament to secure the flap of tissue against the septum, and the filament is cut. Alternatively, the filament is biased to coil to engage the flap of tissue and secure the needle against the septum to close the opening.

Clip-based systems and methods for treating septal defects

Systems and methods for treating internal tissue defects, such as septal defects, with clip-based devices are provided. An exemplary clip-based device includes a tubular body having at least a first and a second deflectable member coupled thereto. The first and second members are coupled on opposite ends of the tubular body and configured to deflect between an undeployed configuration and a deployed configuration. In the deployed configuration, each member extends outwardly away from the tubular body in a position configured to abut a tissue surface. The first and second members are preferably configured to maintain a tissue wall therebetween and at least partially close any opening in the tissue wall.

Methods and apparatus for treatment of patent foramen ovale

TISSUE EXPANSION DEVICE AND RELATED METHODS FOR THERAPEUTIC INTERVENTION

Devices, systems, and methods for suturing tissue

The invention relates to devices, systems, and methods for percutaneously suturing biological material, such as a patient's tissues. In one embodiment, a suturing device includes first and second tissue engaging members connected to one another by a first interconnecting member. In another embodiment, systems and methods are provided for forming holes through two overlapping layers of tissue. Subsequent to forming holes through the two layers of tissue, the suturing device is positioned through the holes to join or bring into contact the two layers of overlapping tissue.

Double spiral patent foramen ovale closure clamp

The present invention provides a device which is adapted to press together the septum primum and the septum secundum between the atrial chambers to close any tunnel in the septum. The device in its preferred form has two clamping members, one on each side of the septum and a central connector which connects the two clamping members and passes through the tunnel. The device is configured to conform to the anatomy such that the tunnel is not substantially deformed by the device. The central connector, in its preferred form has two wires that are spaced apart so that the wires are proximate the lateral sides of the tunnel. The spacing allows the device to be centered at an appropriate location.

Medical clip with radial tines, system and method of using same

Device, system and method for drawing together patient tissue. A central hub has an axis. Several tines are coupled to the central hub. Each of the tines has a tip and is resiliently biased to form a coil. Each tip points radially outward from the axis, with an approximately common angle between adjacent ones of the tines.

Method and apparatus for thoracoscopic intracardiac procedures

Devices, systems, and methods are provided for accessing the interior of the heart and performing procedures therein while the heart is beating. In one embodiment, a tubular access device having an inner lumen is provided for positioning through a penetration in a muscular wall of the heart, the access device having a means for sealing within the penetration to inhibit leakage of blood through the penetration. The sealing means may comprise a balloon or flange on the access device, or a suture placed in the heart wall to gather the heart tissue against the access device. An obturator is removably positionable in the inner lumen of the access device, the obturator having a cutting means at its distal end for penetrating the muscular wall of the heart. The access device is preferably positioned through an intercostal space and through the muscular wall of the heart. Elongated instruments may be introduced through the tubular access device into an interior chamber of the heart to perform procedures such as septal defect repair and electrophysiological mapping and ablation. A method of septal defect repair includes positioning a tubular access device percutaneously through an intercostal space and through a penetration in a muscular wall of the heart, passing one or more instruments through an inner lumen of the tubular access device into an interior chamber of the heart, and using the instruments to close the septal defect. Devices and methods for closing the septal defect with either sutures or with patch-type devices are disclosed.

Method and device for left atrial appendage occlusion

Disclosed is an occlusion device for use in a body lumen such as the left atrial appendage. The occlusion device includes an occlusion member and may also include a stabilizing member. The stabilizing member inhibits compression of the left atrial appendage, facilitating tissue in-growth onto the occlusion member. Methods are also disclosed.

Apparatus and methods for closing septal defects and occluding blood flow

Plugs and methods for plugging septal defects and blood vessels are provided. Plugs are delivered via catheter to a septal defect or a location where it is desired to occlude blood flow in a blood vessel. The plugs are positioned and expanded at the treatment site. The expansion of the plugs can be accomplished passively by using a heat-treated elastic frame or actively by using a balloon to deform a plastically-deforming frame. Plugging structures mounted to the frame span the defect or lumen and prevent blood flow. The plugs described herein have small profiles, and are more reliable than preceding intraluminal transcatheter methods.

Method and apparatus for closing a body lumen

Disclosed is a closure catheter, for closing a body cavity such as a vessel, or the left atrial appendage of the heart. The closure catheter includes a plurality of deployable tissue anchors, which may be laterally deployed into surrounding tissue. The anchors may thereafter be used to draw the tissue radially inwardly, to close the body cavity. Methods are also disclosed.

Method and apparatus for plugging a patent foramen ovale formed in the heart

A percutaneous catheter based method and apparatus for removably plugging a Patent Forman Ovale (PFO) in a patient's heart deploys a threaded surgical plug into the PFO. The plug is removably connected to a flexible connector. The plus is deployed in the PFO by advancing it through a catheter and rotating it into the PFO, then disengaging the flexible connector. The plug may be optionally removed by re-engaging the flexible connector and rotating the plug out of the PFO.

Patent foramen ovale (pfo) closure method and device