RUBUS COREANUS MIQUEL OIL COMPOSITION FOR REDUCING BLOOD URIC ACID LEVELS AND TREATING GOUT

The present invention various physiologically active control function the victims of the significant growth of civilization. As a result growth is advantageous in improving blood value excellent efficacy by the present invention an inferiority of uricase numerical reducing or ventilation has been completed.

The present invention refers to wheat flour-based composition including oil number under public affairs substrate. Said numerical reducing or ventilation improving blood uricase neoplasias.

In the present invention, ventilation (Gout) RM terms representing various diseases group found only it stands human serum (hyperuricemia) increasing the concentration of the uricase, the recurrent acute arthritis conditions result in leukocyte (xynovial fluid leukocyte) (monosodium urate crystal) without determining urate [...] synovial joint mainly exist [...] urate crystal mass of cartilage (tophi) is sometimes needle work ophthalmic distributed around its periphery mono to renal disease symptoms as the fire bowl and dispenser accompanied diseases that show different combination can be shown.

Aeration is our subjective symptoms gradually the air free of human tissues in a multivalent it seeks, five initially conditions modified occurs after opening while subjective symptoms, number one first normally biased until the morning, and feel a slight edema or face of the nails, and fatigue, which are frequently the dilute side conditions, developing step 1, severe pain conditions which broke the pre-night extremities of articulated feel is shown, 2 developing step, while not so continued pain symptoms walking map map overturning as substrate. In addition, such conditions 1 are obvious to select again past weeks or recurrence. And, step complications, uricase compound thereof or diabetes, obesity, hypertension, arteriosclerosis, uremia appearing other [kim forgiveness, aeration is obtained, herb and health, 151 - 154, 2001].

In the present invention, wheat flour-based composition including oil and has efficacy improvement having blood uricase numerical reducing or ventilation, the wheat flour-based oil composition for improving blood including active ingredient can be used for reducing or ventilation numerical uricase.

In the present invention, publicly known method of said wheat flour is wheat flour-based number through the hydraulic oil tank can be seed include both components.

Wheat flour-based method include a number of publicly known oil bath the leucorrhea compression law, it comes the compression law, cold pressing method, solvent extraction, supercritical extraction can be subcritical extraction to one side.

In the present invention, applying heat treatment c the leucorrhea compression law RM heat flowing from the Mars and receives oil by pressing method for obtaining transistors when dye, direction, and gum (Gum) like oil may flow out of the oil when such as caused by a fish cake derivatives and bad in good oil to obtain a crushing when the heat pressing method and without straight, it comes the compression law RM, 100 to 250 °C after bob compressed so as high temperature method and the roasted, provide the means by which cold pressing method, a method to form the oil 43 °C hereinafter mass are disclosed.

For example, the present invention refers to the range from 60 to 200 °C in 60 to 120 minutes or 120 °C 43 °C detour route wheat flour preferably in the range from 120 to 190 °C milking minutes can be obtained oil wheat flour.

In the present invention, solvent extraction said water, organic solvents or mixtures thereof extraction solvent used therein as wheat flour extract a method number bath from seed joined substrate.

The blending ratio of the organic solvent is an organic solvent of one kind or number are specially used when water is not.

E.g., said organic solvent is lower alcohols, hexane, acetone, ethyl acetate, chloroform and selected from the group consisting the latter be with D ethyl ether one or more daily. Said at least one alcohol 1 to 6 carbon atoms be a lower alcohols. For example, lower alcohols include methanol, ethanol, propanol, butanol, normal - propanol, ISO - propanol, normal - butanol, 1 - rearranged pentanols, 2 - butoxyethanol or ethylene glycol can be the vibration-damping material. The organic solvent is acetic acid in addition, DMFO (dimethyl-a formamide), DMSO (dimethyl sulfoxide) polar solvent such as, knight reel acetoacetoxy-functional, ethyl acetate, methyl acetate, new azeotropic, pentane, 2, 2, 4 - tree methyl pentane, orl, cyclohexane, cyclopentane, diisobutylene, 1 - pentene, 1 - chlorobutane, 1 - chloro pentane, o - xylene, diisopropyl ether, 2 - chloropropane, toluene, 1 - chloropropane, chlorobenzene, benzene, diethyl ether, diethyl sulfide, chloroform, dichloro methane, 1, 2 - dichloroethane, [...], diethanol amine, ether, nonpolar solvent such as carbon tetrachloride and THF (Tetrahydrofuran) disapproval.

In one embodiment, said nucleic acid can be a detour route wheat flour-based oil is wheat flour using extracting.

In the present invention, said subcritical or supercritical fluid extraction technique is a subcritical fluid or a supercritical fluid extraction solvent used therein as wheat flour from seed extract a number bath method saying the other.

The principle of the super critical extraction of the existing method such as distillation extraction technology is a combination of techniques, existing techniques and removable and holes are isomers, mixture intended to provide, and switching number polymeric material, from natural plant medicaments, such as perfume including hydrogen or the energy saving production process development method for effective apart wide disclosed.

Such super critical extraction of solvency to extracting material using a supercritical fluid, comprising the steps of separately from which extraction step, the extraction step by the difference between the solubility of the supercritical fluid solvent sample closely together in contact with the supercritical fluid mouth and soluble component in a sample, containing solutes from the extraction step or the separated solute in the supercritical fluid can be separated by pressure. Working conditions (temperature, pressure) by adjusting the extraction step to vary the solvency of supercritical fluid can selectively taken component in an analyte sample specific characteristic, reports the supercritical material allowing ready access to a threshold condition can be a carbon dioxide which might, as well as chemically stable part of the incombustible solute ingredient does not cause deterioration of critical temperature is selected from alumina and charcoal, to extract texture as suitable.

In the present invention by using supercritical or subcritical extraction, for separating solvent and solute hereinafter, an extractor thermally sensitive material which hereinafter for processing at a low temperature, a user adjusts the solubility by temperature and pressure for separation is hereinafter disclosed. In addition, solvent reuse without environmental door number, number no organic solvent can be articles which, while being held by the article with its original flavor number can be achieved. In addition, cool to lower than general organic solvent due to little energy recovery, high purity number article relatively simple process steps can be achieved.

In supercritical or subcritical extraction such as for use in the fluid can be used in a fluid using art grudge without number.

In particular, when using supercritical fluid carbon dioxide, said carbon dioxide is non-flammable and human oil and fat, low critical temperature (31. 1 °C) and critical pressure (73. 8bar) having, a lower viscosity, high extraction efficiency and fast high-diffusing and strong solvent extraction rate has an effect on the ununiform may have.

In addition, the supercritical or subcritical extraction method using general method can be the party industry.

In the present invention used wheat flour-based oil is wheat flour from seed pressing, solvent extraction, as well as obtained in the betulin subcritical or supercritical fluid extraction may also be processed.

10 to 80% by weight of the hydraulic composition in the present invention wheat flour can be content.

On the other hand, the present invention according to wheat flour-based active ingredient including therapeutic composition for reducing or ventilation for improving composition has a number numerical uricase blood, food composition or cosmetic composition can be utilized.

The specification terms in 'active ingredient including' RM wheat flour-based efficacy or activity including achieving the sufficient quantity of significant meaning that the other.

Wheat flour-based food oil is enabled as side effects of the present invention composition administered excess water into the human body components included in the embodiment within a range proper one skilled upper limit is four these components can.

Said therapeutic composition of the present invention rotates about number about number in addition to the active therapeutic using physiologically acceptable auxiliary number number can be tank, said auxiliary number number include excipients, disintegrating number, sweetener number, number coupled, coating number, expansion number, lubricating number, number or flavor [...] number can be use.

In addition to the active therapeutic composition for administration about said number described in addition to said at least one dermatologically acceptable carrier comprising about number 1 can be under anger therapeutic composition preferably about number number number.

Number number number number of form about said granular compositions, acid number, positive number, coated tablets, capsule number, number left, number solution, syrup, juice, suspension number, number can be like oil. For example, the form number number according to the number of positive number or capsules, effective component is ethanol, glycerol, water such as oral, about number can be combined with a non-toxic dermatologically acceptable inert carrier. In addition, desired or if necessary, a suitable binding number, lubricating number, number of the leaving group can be in admixture number in addition disintegrating. A suitable binding number is the number one is but not limited to, starch, gelatin, glucose or beta - natural sugar such as lactose, corn sweetener number, acacia, or sodium bicarbonate [...][...] such as natural and synthetic gum, sodium stearate, magnesium stearate, sodium benzoate, sodium acetate, sodium chloride etc.. The disintegrating number is the number one but not limited to, starch, methyl cellulose, agar, it cuts the toe knit, etc. a thickening.

Further a detail suitable method to Remington's Pharmaceutical Science, Mack Publishing Company, Easton PA method according to the disclosure in response to the disease or components can be preferably according to number number.

Compositions of the present invention can be a salt comprises about number. Therapeutic compositions of the present invention suitable dosage is about number number number of method, administration scheme, patient's age, weight, -, pathological conditions, food, administration time, routes, such as a printed wiring board which is determined by the various speed and reaction sensitive, usually effective for the treatment or prevention of splicing the doctor to a desired dose hereinafter can determine and prescription medications. The preferred embodiment of the present invention, therapeutic compositions of the present invention about number 1 dosage is 0. 001 - 10 g/kg are disclosed.

Therapeutic compositions of the present invention in the embodiment for the invention is about number is provided to a person with skill in the art according to the method hereinafter, a cosmetically acceptable carrier and/or excipient about number number number number number tank unit dose form or otherwise prepared by using the number bath 1308. amount container of muffler. The number may be the solution in oil or aqueous medium, be in the form of suspension or emulsion X number, number powder, granules number, positive number or capsules may be in the form number, number or stabilizing number can be further dispersed.

The present invention refers to in addition wheat flour-based active ingredient including food composition for reducing or ventilation for improving blood uricase numerical number under public affairs substrate.

Said therapeutic composition of the present invention according to food composition in the same manner as health food is about number number number may use, various foods can be added disclosed. The composition of the invention can be added include e.g. food, beverage flow, alcohol beverage flow, confectionery, diet bar, oil number product, meat, chocolate, pizza, if, other noodles, gum type, ice cream flow, vitamin composite number, health food etc..

As well as active ingredient of the present invention oil wheat flour-based food composition, when food is typically added so as to number tank includes the component can be, for example, protein, carbohydrate, fat, nutrient, seasoning number and a flavor number without using a tool. The aforementioned examples of pathogenic agent mono carbohydrate, e.g., glucose, such as oligosaccharides; d company Kara id, e.g. liver, sucrose, such as oligosaccharide; and polysaccharide, for example dextrin, cyclodextrin such as conventional sugars and xylitol, sorbitol, such as processes for the preparation of party alcohol[...] among others. Number flavor as natural flavor number [TAU denaturing, Stevia extract (e.g. [...] A, such as [...]]) and synthetic flavor number (saccharin, aspartame or the like) can be used. For example, food composition of the present invention is coated on the number if in addition to the oil bath of the present invention wheat flour-based on number drinkable beverage citric acid, liquid and an oligosaccharide, sugar, glucose, acetic acid, malic acid, juice, and the like capable of various plant extract further comprises.

In one embodiment, the present invention according to composition can be included in the puree. Puree on food and other food during lost motion?While workpiece current to belong, and said?The fruits or vegetables while workpiece flow based on number bath, machined or the food or food additive graphite applied means disclosed. Puree generally paper bag including concentrate used crushed and paper bag, the present invention according to said puree composition to 0. 1 to 10% by weight by including, uricase numerical reducing or ventilation effect blood can be achieved.

The present invention refers to said wheat flour-based active ingredient including health food including food composition for reducing or ventilation for improving blood uricase numerical number under public affairs substrate. The means by which health food, beverage active ingredient of the present invention, type, flavoring agents, gum, either adding like confectionery material, encapsulated, powdered, suspension or the like number food high pressure liquid coolant, when specific health facility glutinous rpm, unlike general drug side effects can occur when taken drug for a long period of time into a food like bent along the disclosed.

Health food product of the present invention obtained in this way, which consists in taking the pressure on a daily basis and is very useful. The significant health food in wheat flour added amount, depending on the type of food and other health to be strong but define, and without impairing the taste of food and to such an extent that it results in, 0 normal food object. 01 to 50% by weight, preferably 0. 1 to 20% by weight in the range of.

In addition, liquid number, ring number, number granules, or capsules positive number 0 in the form of health functional foods for a credit card number. 1 to 100 weight % preferably 0. 5 to 80% by weight are added in a range of. In one embodiment, number health food product may be a solution of the present invention, can be in the form of capsule number or beverage.

The present invention refers to in addition wheat flour-based active ingredient including cosmetic composition for reducing or ventilation blood uricase numerical number under public affairs substrate.

When the cosmetic, said number tank containing a cosmetic active ingredient is in the form of emulsifier-high pressure liquid coolant or general number number number can be solubilized. For example, flexible skin skin such as skin or nutritional; [...] lotion or body lotion such as emulsion; encapsulated into, moisture cream or icing cream such as cream; essence; cosmetic ointment; spray; gel; pack; sun screen; makeup base; liquid type, solid type or spray type of foundation; powder; cleansing cream, cleansing lotion, cleansing such as oil would make-up number number; cleansing foam, soap, number of body on a wash such as cleaning number may have type.

In addition, a cosmetic active ingredient in addition to said said further fatty substance, organic solvent, dissolved number, concentrated number, gelling number, softening number, antioxidant number, number of suspension, stabilizing number, foam (foaming agent) number, direction number, number surfactants, water, ion emulsion number, nonionic emulsion number, charging number, sequestering number, chelating number, preserving number, vitamin, blocking number, number presented, essential oil, dye, pigment, hydrophilic active number, typically a vagina lipophilic active number or composition based on lipid vesicles such as cosmetic containing number can be.

The active ingredient is such that if said number width cosmetic active ingredient within short time such as on a wash - number would make-up number is maintained skin off (pixel or voxel off) in the case of cosmetic type number or cleaning is operated with a relatively high concentration of said formula 1 may be compounds are disclosed. While, the active ingredient is maintained skin for a prolonged period of water, emulsion, cream or the like in the case of a cosmetic material selected from the group - (leave-of-zeros) type rib on - off type cosmetic is lower than the concentration of active ingredient on a wash reflecting element will. The number is one but not limited to, in one embodiment of the present invention, said active ingredient said composition relative to the weight of the entire composition 0. 0001% by weight to 10% by weight (preferably 0. 0001% by weight to 1% by weight) can be said. Said active ingredient of the present invention composition 0. 0001% by weight less than sufficient source to the skin regeneration, wrinkle, anti-inflammatory or lightening effect cannot be expected, and if greater than 10% by weight such as unwanted reaction occurs or allergic skin safety door number so to prevent this there may be micrographs.

The present invention refers to in addition for improved pharmaceutical or food for ventilation or for reducing blood uricase numerical number jaws said wheat flour-based oil as a toothbrush including complex number under public affairs substrate.

Said oil including the composite compositions as wheat flour-based numerical reducing or ventilation for improving blood uricase can be uses.

In addition the present invention refers to mammal including administering effective amount of wheat flour-based oil composite composition including a number uricase numerical reducing or ventilation method improving blood under public affairs substrate.

Where the methods comprise terms used in "mammal", observing or experiments it is the context of the mammal, preferably human said substrate.

Terms used in "an effective amount" where forward user, veterinarian, are often considered by the physician or other clinical organized orgin, biological or medical active ingredient in animals or humans to a DNA amount or pharmaceutical composition means that, for the relief of symptoms of a disease or disorder comprising inducing the relevant amount. An effective amount of the active ingredient of the present invention for administration and desired effect will be varied in accordance with the skilled nontrivial disclosed. Therefore, optimal dosage is administered can be easily determined by one skilled, type of disease, disease severity, and at least a composition containing other components content, number of types, and patient age, weight, general health, sex and dietary, administration time, routes and compositions secretion rate, a treatment period, including simultaneous use of various factors can be adjustable. Of the present invention prevention, treatment or amelioration in method, in the case of adult, composition of the present invention many times to times when administered 1 1, 0. 001 mg/kg to 10 g/kg administered preferably in an amount.